CN105394322A - Livestock and poultry immunity improving mixing feed additive - Google Patents

Abstract

The present invention discloses a livestock and poultry immunity improving mixing feed additive, wherein the composition comprises grape seed, grape skin, radix bupleuri, milkvetch root, tuckahoe, hawthorn, and a rice bran and bran mixing carrier. According to the present invention, the clinical trial results prove that the composition has effects of effective livestock and poultry immunity improving, good fattening pig growth performance improving, good sow production performance improving, good cow milk production performance improving, and good laying hen egg production performance improving.

Description

A kind of mixed fodder additive improving fowl poultry kind immunity

Technical field

The present invention relates to a kind of mixed fodder additive improving livestock and poultry autoimmunity.

Background technology

Along with the raising of expanding economy and living standards of the people, people favor especially to green, healthy, safety, free of contamination natural food.Especially stricter to the quality requirements of meat, eggs and milk food.But along with the continuous deterioration of environment, cause epidemic disease to increase year by year, also increase year by year the harm of poultry, immunity also declines gradually, causes its productivity ratio, survival rate or quality to decline.Under traditional industrialized aquaculture pattern, livestock and poultry at every moment all can be subjected to the invasion and attack of various pathogenic microorganism, the immunity of organisms of livestock and poultry can resist the invasion and attack of pathogenic microorganism under normal circumstances, along with the decline of immunity, increase the possibility increasing pathogen invasion its body, immune system can not produce normal immune response simultaneously, causes the effect of vaccine to decline, causes the incidence of disease of livestock and poultry to raise.Therefore antibiotic is used in a large number for a long time, but its side effect is also more and more obvious, and beneficial bacterium also kills while can killing harmful bacteria by antibiotic, Long-Time Service can make livestock and poultry produce drug resistance, after causing livestock and poultry to fall ill, drug therapy is invalid, there are the serious problems of medicament residue simultaneously.Traditional Chinese medicine is because its toxicity is little, it is little to endanger, can not produce drug resistance, avoid the advantages such as medicament residue, safe and reliable as feed addictive.

A kind of mixed fodder additive improving immunity of livestock is disclosed for this situation the present invention, the present invention selects some natural drugs such as grape pip, Grape Skin, radix bupleuri, the Radix Astragali, hawthorn, Poria cocos, through extracting the absorptivity of the active principle that can improve in medicine.Prove through clinical testing, this invention is effective.This invention is simple to operate, and low in raw material price is easy to get, and can not produce drug resistance and medicament residue.

Summary of the invention

The object of this invention is to provide a kind of mixed fodder additive improving livestock and poultry autoimmunity.

Described composition comprises grape pip, Grape Skin, radix bupleuri, the Radix Astragali, hawthorn, Poria cocos and rice bran and wheat bran.

Grape pip is the accessory substance produced in Grape processing process, accounts for 4% ~ 6% of whole grain grape weight.Grape pip contains rich in protein, crude fat, each seed amino acid, vitamin and mineral matter etc., has become the focus that Animal nutrition scholars pay close attention to.Good facilitation is had to the egg laying performance of the growth performance of growing and fattening pigs, the production performance of sow, the Milk Production of milk cow and laying hen; Radix bupleuri, clearing heat and detoxicating, anti-inflammatory, expelling wind and clearing away cold, warming lung to reduce watery phlegm, Promote immunity function; The Radix Astragali and Poria cocos have immunologic function and antibacterial action more widely, reduce influenza infection probability; Hawthorn regulates stomach to increase the feed intake of livestock and poultry.

The formula of described composition is: grape pip 25-40 part, Grape Skin 30-40 part, radix bupleuri 15-25 part, Radix Astragali 10-15 part, hawthorn 8-12 part, Poria cocos 9-15 part, rice bran and wheat bran are diluted to 30%-40%.

The formula of described composition is preferably: grape pip 35 parts, Grape Skin 35 parts, radix bupleuri 25 parts, the Radix Astragali 15 parts, hawthorn 10 parts, 15 parts, Poria cocos, rice bran and wheat bran dilute extract to 35%.

The weight ratio of described rice bran and wheat bran is 30:70, and moisture is below 2.5%.

Described composition is completed by following preparation technology:

(1) take radix bupleuri, the Radix Astragali, hawthorn and Poria cocos by recipe quantity, add 10 times of soak by water twice, boil latter 90 minutes at every turn, 200 mesh filter screens filter while hot.Merge twice filtrate, mixing, Vacuum Concentration, when obtaining 60 DEG C, proportion is the medicinal extract of 1.20, and powder is pulverized to obtain in vacuum drying;

(2) take grape pip and Grape Skin by recipe quantity, add 8 times 45%, the ethanol of 60% and 75% successively, 70 DEG C of lixiviates 3 times, each extraction 2.5 hours, reclaim ethanol, 4500 turns/min is centrifugal, get supernatant, 0.22 μm of membrane filtration, filtrate crosses the macroreticular resin chromatographic column 2 times that blade diameter length ratio is 1:10, coutroi velocity is at 1BV/h, first use 30% ethanol rinse, then use the ethanol desorb of 70%, collect stripping liquid, concentrate and obtain the medicinal extract that proportion is 1.20, powder is pulverized to obtain in vacuum drying;

(3) powder of (1) and (2) is mixed, then dilute extract with the rice bran after pulverizing and wheat bran mixed carrier, after fully mixing, cross 50 mesh sieves, packing.

Beneficial effect of the present invention:

This invention compatibility rationally, have no side effect, can improve immunity of organisms, and prepare simply compared with the like product used on a large scale with present plant field, cheap, drug residue free, has good economic worth, can industrial application.

Detailed description of the invention:

Embodiment 1

Embodiment 2

Embodiment 3

Preparation method:

(1) take radix bupleuri, the Radix Astragali, hawthorn and Poria cocos by recipe quantity, add 10 times of soak by water twice, boil latter 90 minutes at every turn, 200 mesh filter screens filter while hot.Merge twice filtrate, mixing, Vacuum Concentration, when obtaining 60 DEG C, proportion is the medicinal extract of 1.20, and powder is pulverized to obtain in vacuum drying;

(2) take grape pip and Grape Skin by recipe quantity, add 8 times 45%, the ethanol of 60% and 75% successively, 70 DEG C of lixiviates 3 times, each extraction 2.5 hours, reclaim ethanol, 4500 turns/min is centrifugal, get supernatant, 0.22 μm of membrane filtration, filtrate crosses the macroreticular resin chromatographic column 2 times that blade diameter length ratio is 1:10, coutroi velocity is at 1BV/h, first use 30% ethanol rinse, then use the ethanol desorb of 70%, collect stripping liquid, concentrate and obtain the medicinal extract that proportion is 1.20, powder is pulverized to obtain in vacuum drying;

(3) 1. embodiment 1: the powder of (1) and (2) is mixed, dilute with the rice bran after pulverizing and wheat bran mixed carrier again, extract is diluted to 30% of mixed carrier weight, after fully mixing, cross 50 mesh sieves, packing.2. embodiment 2: the powder of (1) and (2) is mixed, then dilute with the rice bran after pulverizing and wheat bran mixed carrier, extract is diluted to 35% of mixed carrier weight, after fully mixing, crosses 50 mesh sieves, packing.3. embodiment 3: the powder of (1) and (2) is mixed, then dilute with the rice bran after pulverizing and wheat bran mixed carrier, extract is diluted to 40% of mixed carrier weight, after fully mixing, crosses 50 mesh sieves, packing.

(4) raise, every 100g feed adds 1g this product; Fowl, every 100g feed adds 0.5g this product.

Detailed description of the invention:

Experimental example 1:

1. experiment material and experimental design:

About 7 aa broiler chicken 180g are selected in experiment, and health status is good, is divided into 5 groups at random, often organize 30, totally 150, after feeding 5 days, to every chicken by every 100g body weight chest muscle injection 0.25mlO ₁, O ₂type chicken colibacillosis bacterium liquid, continued to feed to 2 weeks, observed clinical symptoms, and recorded related data.

2. test feed

I group: conventional feed commonly used by commercially available broiler chicken, basal diet;

II group: basal diet adds embodiment 1 feed addictive;

III group: basal diet adds embodiment 2 feed addictive;

IV group: basal diet adds embodiment 3 feed addictive;

V group: basal diet adds the Radix Astragali-ginkgo leaf Chinese medicine additive;

Disease symptom: spirit is depressed, feed consumption reduces, and becomes thin, and feather slightly disorderly, is shed tears in a large number, head and face's oedema, diarrhoea.

Experimental example 2:

1. experiment material and experimental design:

The growing and fattening pigs of health status good SIV negative antibody are selected in experiment, are divided into 5 groups at random, often organize 10, totally 50, after feeding 10 days, to every pig inoculation SIV virus, continue to feed to 30 days, observe clinical symptoms, and record related data.

2. test feed

I group: conventional feed is commonly used in commercially available growing and fattening pigs, basal diet;

II group: basal diet adds embodiment 1 feed addictive;

III group: basal diet adds embodiment 2 feed addictive;

IV group: basal diet adds embodiment 3 feed addictive;

V group: basal diet adds the Radix Astragali-ginkgo leaf Chinese medicine additive; ;

Disease symptom: lassitude, generates heat suddenly, and eye, nose have inflammatory exudate to flow out, expiratory dyspnea, cough, and ight soil is dry and hard, and feed consumption reduces.

As can be seen from experimental result, the feed addictive that the present invention obtains, particularly the feed addictive that provides of embodiment 2 is compared with basal feed, substantially increase the growth rate of livestock and poultry, compared with the similar Chinese medicine preparation feed of interpolation, the incidence of disease of infectious disease obviously declines, and therefore this feed addictive is improve immune level, promote feeding quality and improve culture efficiency to provide the higher feed addictive prescription of a sexual valence.

Claims (6)

1. improve a mixed fodder additive for fowl poultry kind immunity, it is characterized in that, described composition comprises grape pip, Grape Skin, radix bupleuri, the Radix Astragali, Poria cocos, hawthorn and rice bran and wheat bran.

2. a kind of mixed fodder additive improving fowl poultry kind immunity according to claim 1, is characterized in that the formula of described composition is: grape pip 25-40 part, Grape Skin 30-40 part, radix bupleuri 15-25 part, Radix Astragali 10-15 part, hawthorn 8-12 part, Poria cocos 9-15 part, use rice bran and wheat bran dilute extract.

3. a kind of mixed fodder additive improving fowl poultry kind immunity according to claim 1 and 2, is characterized in that with rice bran and wheat bran being that mixed carrier dilutes extract, extract is diluted to the 30%-40% of mixed carrier weight.

4. a kind of mixed fodder additive improving fowl poultry kind immunity according to claim 2, it is characterized in that, described composition comprises grape pip 35 parts, Grape Skin 35 parts, radix bupleuri 25 parts, the Radix Astragali 15 parts, hawthorn 10 parts, 15 parts, Poria cocos, and rice bran and wheat bran dilute extract to 35% of rice bran and wheat bran weight.

5., according to the arbitrary described a kind of mixed fodder additive improving fowl poultry kind immunity of Claims 1-4, it is characterized in that the weight ratio of described rice bran and wheat bran is 30:70, moisture is below 2.5%.

6., according to the arbitrary described a kind of mixed fodder additive improving fowl poultry kind immunity of Claims 1-4, it is characterized in that being completed by following preparation technology:

(1) take radix bupleuri, the Radix Astragali, hawthorn and Poria cocos by recipe quantity, add 10 times of soak by water twice, boil latter 90 minutes at every turn, 200 mesh filter screens filter while hot, merge twice filtrate, mixing, Vacuum Concentration, when obtaining 60 DEG C, proportion is the medicinal extract of 1.20, and powder is pulverized to obtain in vacuum drying;

(2) take grape pip and Grape Skin by recipe quantity, add 8 times 45%, the ethanol of 60% and 75% successively, 70 DEG C of lixiviates 3 times, each extraction 2.5 hours, reclaim ethanol, 4500 turns/min is centrifugal, get supernatant, 0.22 μm of membrane filtration, filtrate crosses the macroreticular resin chromatographic column 2 times that blade diameter length ratio is 1:10, coutroi velocity is at 1BV/h, first use 30% ethanol rinse, then use the ethanol desorb of 70%, collect stripping liquid, concentrate and obtain the medicinal extract that proportion is 1.20, powder is pulverized to obtain in vacuum drying;

(3) powder of (1) and (2) is mixed, then dilute extract with the rice bran after pulverizing and wheat bran mixed carrier, after fully mixing, cross 50 mesh sieves, packing.