CN103168919B - Feed additive for enhancing immunity and promoting growth and feed - Google Patents

Feed additive for enhancing immunity and promoting growth and feed Download PDF

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Publication number
CN103168919B
CN103168919B CN201310117660.3A CN201310117660A CN103168919B CN 103168919 B CN103168919 B CN 103168919B CN 201310117660 A CN201310117660 A CN 201310117660A CN 103168919 B CN103168919 B CN 103168919B
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parts
feed
feed addictive
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feed additive
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CN103168919A (en
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胡洪平
吴刚
蒋勇
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Sichuan Huibo Veterinary Medicine Technology Co Ltd
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Sichuan Huibo Veterinary Medicine Technology Co Ltd
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Abstract

The invention discloses a feed additive for enhancing immunity and promoting growth. The feed additive consists of the following components in parts by weight: 12-30 parts of astragalus, 12-20 parts of rhizoma ligustici wallichii, 10-20 parts of angelica, 10-20 parts of radix paeoniae alba, 10-20 parts of geranium strictipes, 12-30 parts of pomegranate peel, 10-15 parts of saposhnikovia divaricata, 8-15 parts of tangerine peel, 8-15 parts of fructus schisandrae and 8-15 parts of hawthorn. The feed additive is reasonable in formula, and has the efficacies of strengthening healthy qi to eliminate pathogens, tonifying qi and strengthening exterior, invigorating spleen and appetizing, resolving food stagnation, replenishing blood and engendering liquid, and the like. The feed additive disclosed by the invention can be directly added into feed and used for enhancing immunity and promoting growth of poultry after feeding so as to improve the production effectiveness of the poultry.

Description

A kind of feed addictive and feed thereof that strengthens immunity and promote growth
Technical field
The invention belongs to feed additive field, relate to a kind of feed addictive that strengthens immunity and promote growth, also relate to the feed that contains feed addictive.
Background technology
Along with socioeconomic fast development, livestock and poultry cultivation intensive degree is more and more higher.In modernization intensive culture process, the prevention and control situation of disease, the number of animals raised, survival rate and the price of deed of poultry are the main sources of culture benefit.Culturist has taked raising stocking density for this reason, feed high nutrient fodder, for a long time in feed, add antibiotic and chemicals and prevent epidemic disease, frequently use disinfectant, improve the measures such as breeding environment of poultry, make poultry in high-intensity antibiotic and chemicals pressure and high load capacity, height stress physiology critical condition.In this state, very easily there is epidemic disease in poultry, reduces on the contrary production performance, causes the medicament residue of the goods such as meat, egg simultaneously, and human health has been formed to great threat.
Increase stocking density and frequently use disinfectant easily to cause stress reaction, environment disturbance in poultry, immunity reduces; The high nutrient fodder of feeding, easily causes higher digestion and metabolism burden; Heavy dose of, use antibiotic and chemicals to be added into feed diseases prevention for a long time, usually damage stomach Qi, cause feed intake and decline, and cause the generation of cause of disease drug resistance and medicament residue, even cause that liver drug metabolic is poisoning.Therefore, necessary research can strengthen body immunity, improve taste function, can reduce or eliminate drug resistance and medicament residue again, improve poultry defending and fighting against diseases, somatotrophic feed addictive.
Summary of the invention
In view of this, one of object of the present invention is to provide feed addictive, and its formula rationally, can strengthen the immunity of poultry, simultaneously growth promotion; Two of object of the present invention is to provide the feed that contains feed addictive.
For achieving the above object, technical scheme is:
1. strengthen immunity and promote the feed addictive of growth, composed of the following components by weight: Radix Astragali 12-30 part, Ligusticum wallichii 12-20 part, Radix Angelicae Sinensis 10-20 part, root of herbaceous peony 10-20 part, mountain on the other way round disappear 10-20 part, granatum 12-30 part, windproof 10-15 part, dried orange peel 8-15 part, fruit of Chinese magnoliavine 8-15 part and hawthorn 8-15 part.
Preferably, composed of the following components by weight: 12 parts of the Radixs Astragali, 12 parts of Ligusticum wallichiis, 10 parts of Radix Angelicae Sinensis, 10 parts of the root of herbaceous peonys, mountain on the other way round disappear 8 parts of 10 parts, 12 parts of granatums, windproof 10 parts, 8 parts of dried orange peels, 8 parts, the fruit of Chinese magnoliavine and hawthorn.
In the present invention, the effect of each component is as follows:
The Radix Astragali has another name called yellow over sixty years of age, is the general designation of plant and Chinese medicine.The Chinese medicine Radix Astragali is the root of leguminous herbaceous plant's astragalus mongolicus, Astragalus membranacus, has the effects such as invigorating qi for strengthening superficies, sharp water detumescence, pus draining and toxin expelling, myogenic.
Ligusticum wallichii be samphire Ligusticum wallichii ( ligusticum chuanxiong Hort.) rhizome; Warm in nature, pungent, return liver, courage, the heart channel of Hang-Shaoyin, cure mainly blood-activating and qi-promoting, wind-expelling pain-stopping.
When be classified as umbelliferae angelica ( angelica sinensis(Oliv.) Diels) root.Warm in nature, taste is sweet, pungent; Return liver, the heart, the spleen channel; Having enriches blood invigorates blood circulation, menstruction regulating and pain relieving and the effect that relaxes bowel, for sallow, the dizzy palpitaition of the deficiency of blood, irregular menstruation, through closing dysmenorrhoea, asthenia cold abdominalgia, the dry constipation of intestines, arthralgia due to wind-dampness, injury from falling down, ulcer sores etc.
The root of herbaceous peony be Ranunculaceae Paeonia plant RADIX PAEONIAE ALBA ( paeonia sterniana Fletcher in Journ.) root.Bitter acid, cool, there is nourishing blood and liver, slow middle pain relieving, astringe yin is received the effect of sweat; Cure mainly chest abdomen pain over the hypochondriac region, rush down dysentery stomachache, spontaneous sweating, fever due to yin deficiency, irregular menstruation, uterine bleeding, is with inferior symptom.
Dried orange peel be rutaceae orange ( citrus reticulata Blanco) and the maturate peel of variety, there is the effect that the appetizing of regulating the flow of vital energy is eliminating dampness and eliminating phlegm, control the spleen-stomach diseases.
The fruit of Chinese magnoliavine be perennial fallen leaves liana magnoliaceae schisandra ( schisandra chinensis (Turcz.) Baill.) or schisandra chinensis ( schisandra sphenantheraRehd.etWils.) dry mature fruit.There is convergence astringent or styptic treatment for spontaneous sweating, nourishing generate fluid, the effect of kidney calming.
Windproof be Umbelliferae herbaceos perennial windproof ( saposhnikovia divaricata (Turcz.) Schischk.) dry root; Taste is pungent, sweet, slightly warm in nature; Return bladder, liver, the spleen channel; Have expel pathogenic wind from the body surface, removing dampness to relieve pain and effect that only convulsion is jerked surely, cure mainly diseases caused by external factors illness that has not attacked the vital organs of the human body, rubella itch, arthralgia due to wind-dampness, lockjaw.
Mountain on the other way round disappear for dicotyledon Asclepiadaceae cynanchum auriculatum Royle ( cynanchumauriculatum rayleex Wight) piece root; There is filling liver kidney; Strengthening the bones and muscles; Strengthening the spleen and stomach; The effects such as removing toxic substances.
Granatum be Punicaceae plant pomegranate ( punica granatum L.) dry pericarp; Sour and astringent, temperature, poisonous; Enter large intestine, kidney channel; There are puckery intestines, hemostasis, insect-expelling function.
Hawthorn be rosaceous plant large-fruited Chinese hawthorn ( crataegus pinnatifida Bge. var. major N. E. Br.) or hawthorn ( crataegus pinnatifida Bge.) dry mature fruit, taste is sweet, sour, slightly warm in nature; Enter spleen, stomach, Liver Channel; Cure mainly food digesting stomach fortifying, the promoting the circulation of qi stasis of blood of faling apart.
2. the feed that contains described feed addictive.
Preferably, in described feed, the percentage by weight of feed addictive is 0.5-1%.
Preferred, in described feed, the percentage by weight of feed addictive is 0.75%.
Beneficial effect of the present invention is: feed addictive disclosed by the invention, formula rationally, according to the physilogical characteristics of poultry, take into full account the combination principle of eighteen incompatibilities and the nineteen counteraction of Chinese medicine, press the principles of formulating prescriptions of the monarch of Chinese medicine, after the mutual compatibility of each component, adopt length and mend short, collaborative formed mutually; In formula with Radix Astragali invigorating qi for strengthening superficies, windproof expelling pathogenic wind from the body surface, Chinese angelica blood supplementing is invigorated blood circulation, Ligusticum wallichii blood-activating and qi-promoting, root of herbaceous peony nourishing blood and liver, astringe yin are received sweat, mountain on the other way round disappear kidney tonifying, invigorating the spleen, astringent or styptic treatment for spontaneous sweating, the nourishing generate fluid of fruit of Chinese magnoliavine convergence, the puckery intestines of granatum, expelling parasite, the dried orange peel appetizing of regulating the flow of vital energy, hawthorn digesting stomach invigorating, the loose stasis of blood of promoting the circulation of qi, all medicine phases 5, to reach the effect of strengthening vital QI to eliminate pathogenic factors, invigorating qi for consolidating superficies, spleen benefiting and stimulating the appetite, promoting digestion and removing indigestion, enriching blood and promoting secretion of body fluid; By modern veterinary viewpoint, livestock fodder additives disclosed by the invention can strengthen the immunologic function of animal body, improves the utilization ratio of feed and promotes the effect that poultry grows; Meanwhile, livestock fodder additives disclosed by the invention is used Chinese medicine preparation, can avoid the generation of cause of disease drug resistance, reduces chemicals residual, improves the productivity effect of poultry.
Accompanying drawing explanation
Fig. 1 is that feed addictive is to colibacillary fungistatic effect.
Fig. 2 is the fungistatic effect of feed addictive to salmonella.
The specific embodiment
Below in conjunction with accompanying drawing, the preferred embodiments of the present invention are described in detail.
Embodiment 1
A feed addictive that strengthens immunity and promote to grow, composed of the following components by weight: 22 parts of the Radixs Astragali, 16 parts of Ligusticum wallichiis, 15 parts of Radix Angelicae Sinensis, 15 parts of the root of herbaceous peonys, mountain on the other way round disappears 15 parts, windproof 15 parts, 12 parts of dried orange peels, 12 parts, the fruit of Chinese magnoliavine, 16 parts of 12 parts of hawthorn and granatums.
For the ease of absorbing, the feed addictive of above-mentioned formula is added in pulverizer and pulverized respectively, after mixing, cross 80 mesh sieves, then save backup.
The preparation method of poultry feed: feed addictive is added in poultry feed, and the weight ratio that adds rear feed addictive is 0.5%.
Embodiment 2
A feed addictive that strengthens immunity and promote to grow, composed of the following components by weight: 30 parts of the Radixs Astragali, 20 parts of Ligusticum wallichiis, 20 parts of Radix Angelicae Sinensis, 20 parts of the root of herbaceous peonys, mountain on the other way round disappears 20 parts, windproof 13 parts, 15 parts of dried orange peels, 15 parts, the fruit of Chinese magnoliavine, 30 parts of 15 parts of hawthorn and granatums.
For the ease of absorbing, the feed addictive of above-mentioned formula is added in pulverizer and pulverized respectively, after mixing, cross 60 mesh sieves, then save backup.
The preparation method of poultry feed: feed addictive is added in poultry feed, and the weight ratio that adds rear feed addictive is 1%.
Embodiment 3
A feed addictive that strengthens immunity and promote to grow, composed of the following components by weight: 12 parts of the Radixs Astragali, 12 parts of rhizomes of chuanxiong, 10 parts of Radix Angelicae Sinensis, 10 parts of the root of herbaceous peonys, mountain on the other way round disappears 10 parts, and windproof 10 parts, 8 parts of dried orange peels, 8 parts, the fruit of Chinese magnoliavine, 12 parts of 8 parts of hawthorn and granatums.
The feed addictive of above-mentioned formula is added in pulverizer and pulverized respectively, after mixing, cross 100 mesh sieves, then save backup.
By feed addictive, for the preparation of poultry feed, its preparation method is: feed addictive is added in normal poultry feed, and the weight ratio that adds rear feed addictive is 0.75%.
Embodiment 4
The bacteriostatic test of the feed addictive of embodiment 1 ~ 3 formula:
Feed addictive is prepared into water extraction liquid, concrete grammar is: feed addictive (mixture after the pulverizing) 100g that gets respectively embodiment 1, embodiment 2 and embodiment 3, then add the distilled water immersion 40 minutes that is equivalent to 10 times of feed addictive weight, after boiling, with slow fire boiling 30 minutes, then use 8 layers of filtered through gauze; The dregs of a decoction add and are equivalent to the distilled water of 10 times of feed addictive weight and with slow fire boiling 30 minutes, then use 8 layers of filtered through gauze; Merge 2 times filtrate, it is 1 g/mL that the slow fire of take is concentrated into crude drug content in liquid, 120 ℃ of autoclavings 20 minutes, and 4 ℃ of Refrigerator stores are standby.
The preparation of the antibacterial scraps of paper: with card punch, filter paper is broken into the disk of diameter 6 mm, put 100 in each bottle, 140 ℃ of hot air sterilizations 2 hours.The liquid of getting crude drug content that 1 mL prepared and be 1 g/mL adds in the bottle that 100 drug sensitive test papers are housed, the drug sensitive test paper of sterilizing is added to the butylamine kalamycin of 1 mL concentration 100mg/mL in contrast simultaneously, soaking at room temperature 2 hours, dry by culture dish seasoning, 4 ℃ of Refrigerator stores are standby.
Extracorporeal bacteria inhibitor test: enteropathogenic E.Coli and the salmonella ordinary broth culture of getting respectively clinical separation, evenly coat nutrient agar panel (peptone 1%, beef extract 0.3%, sodium chloride 0.5%, agar 1.5% ~ 2.0%, distilled water preparation, pH 7.2 ~ 7.4) on, each flat board is done 5 repetitions, cultivate 24 hours for 37 ℃, then by embodiment 1, water extraction liquid prepared by the formula of embodiment 2 and embodiment 3 and butylamine kalamycin are to the antibacterial result of Escherichia coli as shown in Figure 1, to the antibacterial result of salmonella as shown in Figure 2, then according to antibacterial outcome measurement, suppress bacterium loop diameter, measurement result is antibacterial the results are shown in Table 1.
Criterion: antibacterial circle diameter >=19 mm is extremely sensitive; 14-19 mm is medium sensitivity; 10-14 mm is low responsive; ≤ 10 mm are resistance.
The bacteriostatic test of the water extraction liquid of table 1, feed addictive
Figure 583508DEST_PATH_IMAGE001
As shown in Table 1, water extraction liquid prepared by the feed addictive of embodiment 1, embodiment 2 and embodiment 3 all has certain bacteriostasis to enteropathogenic E.Coli and salmonella, and wherein the water extraction liquid of embodiment 2 and embodiment 3 preparations has medium fungistatic effect.Therefore, feed addictive disclosed by the invention has the function of the growth and breeding that suppresses pathogenic.
Experimental example 5
The impact of feed addictive disclosed by the invention on Sichuan White Goose production performance and Development of Immune Organs, concrete grammar is:
(1) animal and basal diet: choose 240 of same batch of certain goose field, Sichuan healthy and strong young geese on the 1st.Experimental basis daily ration forms the foster goose of the < < writing with reference to Wang Zhiyue and produces complete works of > > preparation, and the percentage by weight of each component is: corn 57.1%, wheat 6.0%, wheat bran 5.8%, dregs of beans 17.3%, peanut cake 2.5%, rapeseed cake 1.5%, fish meal 5.0%, calcium monohydrogen phosphate 1.4%, stone flour 1.2%, salt 0.3%, premix 1.0%, lysine 0.05%, methionine 0.2%, carnitine 0.15%.
(2) test grouping with process: 240 young geese are divided into 4 groups at random, and 60 every group, then 3 repetitions are set by every group, each repeats 20 young geese.I group is blank group: the basal diet of feeding; II group is processed group 1: the basal diet containing embodiment 1 feed addictive of the same amount of feeding, feed addictive accounts for the 1.0%(mass fraction of basal diet); III group is processed group 2, the basal diet containing embodiment 2 feed addictives of the same amount of feeding, feed addictive accounts for the 1.0%(mass fraction of basal diet); IV group is processed group 3: the basal diet containing embodiment 3 feed addictives of the same amount of feeding, feed addictive accounts for the 1.0%(mass fraction of feed addictive).Brood time adopts drylot feeding and adds bedding and padding, and within the 1st week, temperature is controlled at 28-30 ℃, declines weekly 2 ℃ later.The young goose of each test group greenfeed with the weight such as blank group basal diet of feeding, feeds 6 times on (50 grams of-200 grams/every plumages, basal diet and greenfeed are the ratio mixed feeding of 1:2 by weight) every day, allows young goose freely drink cold boiling water.
(3) test index and method: from on-test every 1 week (1,7,14 and 21 age in days), take and repeat to calculate as the empty stomach body weight that unit weighs young goose average weight and the daily gain of young goose in each group, observe the health condition of young goose every day, record dead quantity, be calculated to be motility rate, result is as shown in table 2.
Table 2, the impact of feed addictive on production performance
Figure 397880DEST_PATH_IMAGE002
As shown in Table 2, feed and containing the young goose of the feed addictive of embodiment 1, embodiment 2 and embodiment 3, compare daily gain with blank group and improve 5.7%, 8.2% and 11.3%, survival rate is also higher than blank group, and therefore feed addictive disclosed by the invention can improve survival rate and the average daily gain of young goose.
During 21 age in days, from each repeats, randomly draw 3 young geese, weigh on an empty stomach, neck bloodletting is lethal, wins spleen, thymus gland and the bursa of farbricius and weighs, and adaptive immune organ weight, calculates Immune Organs Index, and result is as shown in table 3.
The computing formula of Immune Organs Index is as follows: Immune Organs Index=immune organ heavy (mg)/empty stomach body weight (g).
Table 3, the impact of feed addictive on Immune Organs Index
Group Thymus index Bursa of farbricius index Index and spleen index
Blank group 3.97±0.14 3.85±1.01 2.02±0.13
Processed group 1 4.02±0.09 4.16±0.52 2.18±0.07
Processed group 2 4.15±0.18 4.31±0.60 2.31±0.20
Processed group 3 4.06±0.03 4.28±0.35 2.17±0.05
As shown in Table 3, the Immune Organs Index of feeding containing the young goose of the feed addictive of embodiment 1, embodiment 2 and embodiment 3, all higher than blank group, illustrates that feed addictive disclosed by the invention can promote the growth of young goose immune organ.
Experimental example 6
The impact of feed addictive of the present invention on Luo Man growth performance of chicks and immune level, concrete grammar is:
(1) animal and basal diet: choose 300 of 1 age in days Luo Man chick.Experimental basis daily ration needs (the 9th revised edition) preparation with reference to poultry nutrition, is to the percentage by weight of component: corn 60.1%, dregs of beans 24 %, wheat bran 9.5%, fish meal 2.5%, lysine 0.1%, methionine 0.15%, stone flour 1.4%, calcium monohydrogen phosphate 1.35%, salt 0.3%, multidimensional 0.2%, mineral matter 0.3%, 50% Choline Chloride 0.1%.
(2) test grouping and processing: during 7 age in days, remove excessive and too small weak chick, select 240Zhi healthy chick to be divided at random 4 groups, 60 every group, then each group arranges in 3 groups and repeats, and each repeats 20 young geese.I group is blank group, the basal diet of feeding; II group is fed containing the basal diet of embodiment 1 feed addictive, and the percentage by weight of feed addictive is 1.0 %; III group is fed containing the basal diet of embodiment 2 feed addictives, and the percentage by weight of feed addictive is 1.0 %; IV group is fed containing the basal diet of embodiment 3 feed addictives, and the percentage by weight of feed addictive is 1.0 %.Test breeding chickling is in the wire mesh cage through flame disinfection, and the corresponding group feed of feeding, feeds 6 times (basal diet and greenfeed are by weight being 1:2 mixed feeding, and scale of feeding is 50 grams of-200 grams/every plumages), and allow chick freely drink cold boiling water every day.Grouping was chosen 3 chick at random at every group of same day, and ewcastle disease HI antibody titer is measured in heart blood sampling.By ewcastle disease IV, be that seedling carries out eye droppings and collunarium to all test chickens simultaneously, in immunity, within latter 15 days, measure the antibody titer of ewcastle disease.After immunity 15 days, randomly draw 3 chickens for every group, heart blood sampling, separation of serum, then, with the tiring of β-microdetermination newcastle epidemic disease antibody, result is as shown in table 4.
Table 4, feed addictive detect to Luo Man chicken Newcastle disease immune antiboidy tire (log2)
Group 7 ages in days 22 ages in days Than blank group, improve (%)
Blank group 3.4±0.25 6.5±0.20
1 group, Chinese medicine 3.6±0.49 6.9±0.55 6.16
2 groups, Chinese medicine 3.4±0.32 7.0±0.40 7.69
3 groups, Chinese medicine 3.5±0.37 7.2±0.92 10.77
As can be seen from Table 4, feed containing the chick of embodiment 1, embodiment 2 and embodiment 3 feed addictives, antibody titer of ND improves 6.16%, 7.69% and 10.77% than blank group, illustrate that Chinese medicine of the present invention can obviously improve ND Vaccine immune antiboidy level, has immunological enhancement.
Production performance test: from on-test every 1 week (7,14,21 and 28 age in days), to repeat to weigh into unit average weight and the daily gain of the empty stomach body weight calculating chick of chick in each group, observe the health condition of chick every day, record dead quantity, be calculated to be motility rate, the results are shown in Table shown in 5.
Table 5, the impact of feed addictive on Luo Man chick production performance
Figure 908758DEST_PATH_IMAGE003
During 28 age in days, from each repeats, randomly draw 3 chick, weigh on an empty stomach, neck bloodletting is lethal, wins spleen, thymus gland and the bursa of farbricius and weighs, and obtains immune organ weight, then calculates Immune Organs Index, the results are shown in Table shown in 6.
Heavy (the mg)/live body of Immune Organs Index=immune organ heavy (g).
Table 6, the impact of feed addictive on Luo Man Immune Organs Index of Chicks
Group Thymus index Bursa of farbricius index Index and spleen index
Blank group 3.34±0.31 3.43±0.92 2.17±0.27
1 group, Chinese medicine 3.60±0.44 3.47±0.66 2.29±0.24
2 groups, Chinese medicine 3.92±0.36 3.65±0.55 3.09±1.01
3 groups, Chinese medicine 3.84±0.72 4.02±1.17 3.13±1.48
From table 5-6, feed and containing the chick of embodiment 1, embodiment 2 and embodiment 3 feed addictives, compare daily gain with blank group and improve respectively 3.7%, 6.5% and 7.5%, and the Immune Organs Index of three groups of chick is all higher than blank group, illustrate that Chinese medicine of the present invention can improve survival rate and the daily gain of chick, promote the growth of immune organs of chicken treated.
Finally explanation is, above preferred embodiment is only unrestricted in order to technical scheme of the present invention to be described, although the present invention is described in detail by above preferred embodiment, but those skilled in the art are to be understood that, can to it, make various changes in the form and details, and not depart from the claims in the present invention book limited range.

Claims (5)

1. one kind strengthens immunity and the feed addictive that promotes growth, it is characterized in that, composed of the following components by weight: Radix Astragali 12-30 part, Ligusticum wallichii 12-20 part, Radix Angelicae Sinensis 10-20 part, root of herbaceous peony 10-20 part, mountain on the other way round disappear 10-20 part, granatum 12-30 part, windproof 10-15 part, dried orange peel 8-15 part, fruit of Chinese magnoliavine 8-15 part and hawthorn 8-15 part.
2. feed addictive according to claim 1, it is characterized in that, composed of the following components by weight: 12 parts of the Radixs Astragali, 12 parts of Ligusticum wallichiis, 10 parts of Radix Angelicae Sinensis, 10 parts of the root of herbaceous peonys, mountain on the other way round disappear 8 parts of 10 parts, 12 parts of granatums, windproof 10 parts, 8 parts of dried orange peels, 8 parts, the fruit of Chinese magnoliavine and hawthorn.
3. the feed that contains feed addictive described in claim 1 or 2.
4. feed according to claim 3, is characterized in that: in described feed, the percentage by weight of feed addictive is 0.5-1%.
5. feed according to claim 4, is characterized in that: in described feed, the percentage by weight of feed addictive is 0.75%.
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