CN108703265B - Herbal additive for promoting sheep growth and preparation and use methods thereof - Google Patents
Herbal additive for promoting sheep growth and preparation and use methods thereof Download PDFInfo
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- CN108703265B CN108703265B CN201810520660.0A CN201810520660A CN108703265B CN 108703265 B CN108703265 B CN 108703265B CN 201810520660 A CN201810520660 A CN 201810520660A CN 108703265 B CN108703265 B CN 108703265B
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Abstract
The invention discloses a herbal medicine additive for promoting sheep growth and a preparation method and a using method thereof, wherein the herbal medicine additive comprises the following components in percentage by mass: 8-10 parts of paederia scandens, 3.5-5 parts of radix codonopsis pilosulae, 3.5-5 parts of cynanchum wilfordii, 3.5-5 parts of bighead atractylodes rhizome, 1.5-2.5 parts of clerodendrum bungei root, 1.5-2.5 parts of gorse, and 0.5-1.5 parts of litsea cubeba. The manufacturing method comprises the following steps: respectively pulverizing herba Paederiae, radix Codonopsis Pilosulae, radix Cynanchi Wilfordii, Atractylodis rhizoma, radix clerodendri bungei, flos Caraganae Sinicae and fructus Litseae Pungentis, and sieving with 220 mesh sieve of 180 meshes; mixing herba Paederiae, radix Ginseng, radix Cynanchi Wilfordii, Atractylodis rhizoma, radix clerodendri bungei, flos Caraganae Sinicae and fructus Litseae uniformly at a certain mass ratio. The using method comprises the following steps: the herbal additive accounting for 0.25-0.5 percent of the total weight of the sheep ration is uniformly mixed with the sheep food and then fed for administration. The invention is composed of Yi nationality common medicines with functions of guiding qi downward and nourishing, has the efficacies of promoting qi circulation, strengthening spleen and tonifying liver and kidney, is suitable for being used in winter with cold climate and lacking of green feed, and can obviously improve the weight gain rate and the resistance to diseases of 3-6 month-old sheep after being continuously used for 60 days.
Description
Technical Field
The invention relates to the technical field of sheep feed additives, in particular to a herbal medicine additive for promoting sheep growth and a preparation method and a use method thereof.
Background
The Liangshan state possesses rich characteristic Yi-nationality herbal medicine (Yi-nationality medicine for short) resources, and in the big background of a project [1] listed in the development center of the national feed industry development strategy in the last ten years, the novel, pollution-free and multifunctional sheep-using Yi-nationality medicine feed additive is developed aiming at the unique Yi-nationality medicine resources of the Liangshan state and the vigorously developed sheep breeding industry according to the unique Yi-nationality medicine theory, so that the development of the green sheep breeding industry with the Liangshan state characteristics is promoted, safe and pollution-free sheep products are produced, and the ecological environment of the Liangshan state is protected.
At present, the research of using Yi medicine as animal feed additive at home and abroad is still blank. In Liangshan, more than 1000 kinds of long-term and unique Yi medicine resources are widely used for preventing and treating human diseases, and many Yi medicines have the characteristics of homology and common use with food and have double functions of nutrition and medicines, thereby providing valuable resources for developing natural livestock and poultry feed additives with the characteristics of Liangshan.
The Yiyi medicine with Liangshan characteristics belongs to a natural medicine as the traditional Chinese medicine, and has the outstanding advantages of low cost, wide source, simple and convenient processing, safety, effectiveness and the like when being used as a feed additive. According to incomplete statistics, more than 200 Chinese herbal medicines in more than 1000 Chinese herbal medicines clinically used by veterinarians at present can be used as feed additive raw materials [2], and have various effects of improving the quality of livestock and poultry products, improving the quality of feeds, preventing diseases, protecting health and the like.
The research of the traditional Chinese medicines in the livestock breeding aspect can be used for reference by developing the Liangshan special Yi-nationality medicine into the sheep feed additive. According to reports, the Sudan [3] and the like are added with compound traditional Chinese medicine superfine powder feed consisting of radix codonopsitis, angelica, astragalus, hawthorn, malt, honeysuckle and common andrographis herb with 0.5 percent of basic daily ration in the feed for fattening pigs to feed the fattening pigs, so that the effects of improving daily gain, disease resistance and total oxidation resistance of serum and reducing the feed-weight ratio and the content of serum Malondialdehyde (MDA) can be achieved. The Ma Mingzhi [4] adds 20g of traditional Chinese medicine powder such as astragalus root, uniflower swisscentaury root, angelica, cowherb seed, beautiful sweetgum fruit, ricepaperplant pith and the like into daily ration of the milk goat in the lactation peak period, so that the milk yield of the goat is remarkably improved, and the daily income increase can reach 36 yuan. The result of adding superfine powder of astragalus root, licorice, selfheal, reed rhizome, gypsum, mint and other Chinese medicinal materials in different dosages into daily ration of laying hens by Sun-Qi Ying and other [5], shows that the addition amount of 1.0% can obviously improve the content of heat shock protein 70 in serum of laying hens, is 63.3% higher than that of blank groups, reduces liver and muscle damage of laying hens in heat stress, and enhances the heat stress resistance of organisms. The results of 0.25%, 0.5% and 1% of Chinese herbal medicine ultrafine powder agents are respectively added into basic daily ration of 21-day-old weaned piglets in Zhao hongmei and the like [6], show that compared with antibiotics, the Chinese herbal medicines in each group have no obvious difference on the influence of biochemical indexes of blood of the piglets, but can obviously improve the levels of thyroxine T3 and T4 of the piglets, and the formula can promote the growth of the piglets. Zhang Shi Chang et al [7] adopts crude extracts of 3 Chinese medicines of barberry root, astragalus root and hawthorn fruit to be added into the daily ration of weaned pigs according to the dosage of 0.125 percent and 0.25 percent, has the trend of improving the weight and daily gain of the piglets, and can obviously reduce the feed conversion ratio and the diarrhea rate; the high-dose traditional Chinese medicine crude extract can improve GSH-PX by 30.4%, can also improve the level of serum superoxide dismutase (SOD), reduces the content of MDA, and improves spleen index, which indicates that the traditional Chinese medicine additive can improve the antioxidation function of piglets and promote the development of immune organs. The Chinese medicines of epimedium, broomrape, dodder, wolfberry fruit, morinda root and astragalus root etc. 8 are added into the daily ration of ram according to the dose of 10g/d, thus obviously increasing the content of reproductive hormone of ram's plasma follicle stimulating hormone, testosterone and luteinizing hormone etc. and finally improving the production performance. Guo Jianying et al [9] adding superfine powder of compound traditional Chinese medicine raw astragalus, motherwort, angelica, dandelion, tuckahoe, hawthorn, purslane, rhizoma atractylodis, raw liquorice, dried orange peel and the like into daily ration of lactating sows at the dosage of 7.5g/kg and 15g/kg can obviously improve the rosette rate of red blood cells E-C3bR of sows, the CD4+/CD8+ of lymphocytes and improve the contents of serum immunoglobulin, IL-2, IL-10, TNF-alpha and IFN-gamma, and shows that the adding of the superfine powder of the compound traditional Chinese medicine into the feed of the lactating sows can improve the immunologic function of the sows. Gong Wei Zhong, etc. [10] adding the astragalus root, the malt, the common andrographis herb, the codonopsis pilosula, the glossy privet fruit and other compound traditional Chinese medicine superfine powder into daily ration of the chickling according to the dosage of 0.25 percent and 0.5 percent respectively, and adding the traditional Chinese medicine coarse powder into the daily ration of the chickling according to the dosage of 1.0 percent, compared with a blank control group, the weight of the 0.5 percent traditional Chinese medicine superfine powder group and the 1 percent traditional Chinese medicine coarse powder group is obviously improved, the material-meat ratio is reduced, the T-AOC and SOD; tests show that the 0.5 percent Chinese medicinal superfine powder can improve the production performance and the oxidation resistance of broiler chickens, has the same curative effect as 1 percent Chinese medicinal coarse powder, and can obviously reduce the dosage of medicinal materials. Li Chun Yan and so on [11] add 5% of dosage of compound Chinese herbal medicine powder of tuber fleeceflower root, basket fern, hawthorn, malt, dried orange peel, medicated leaven, white peony root, radix astragali, eucommia bark, Chinese yam, radix codonopsitis, pine needle and so on into the daily ration of 3-month-old sheep, can obviously promote the weight gain of sheep, have raising effects on most indicators of red cells and white cells, and have reducing effects on the number of platelets; meanwhile, the Chinese herbal medicine additive can improve the immune function of the organism, and the action effect is positively correlated with the additive amount. Different formulas are selected for the Liu Aixia [12], the traditional Chinese medicine formula is crushed and then added into daily ration to feed the milk goat, and the result shows that the effect of improving the milk yield of the milk goat, improving the milk quality and increasing the economic benefit is best when the additive amount is 1%.
Compared with China, foreign research on natural medicine feed additives is relatively late. In the Sulian, acanthopanax root was used as a feed additive in the 60 th of the 20 th century, and a good effect is achieved. In the 70 s of the 20 th century, Japan extracted effective ingredients from garlic as animal growth promoters. In recent years, much attention has been paid to Chinese herbs and their use as feed additives, especially in the direction of plant extracts, in many countries such as the United states, Canada, Germany, Singapore. In asia, japan and korea are countries where studies on plant extracts were performed earlier. The European and American countries have also carried out large-scale research on their traditional medicinal plants, and have applied for many patents on the basis of the research, and developed many products for human and animal production. The types of plants studied in foreign countries include vegetable, fruit, green tea, onion, garlic, clove, locust tree leaf, juniper, malt, marigold, peach, panda leaf, thistle, coptis, sage, cardamom, bay, extracts or essential oils of herbs/oregano, seaweed, mushroom and others [13-14], but the results are rarely applied in the feed industry. The volatile essential oil additive extracted from oregano is a novel feed additive product which appears in almost twenty years and is applied to certain range in European and American areas, the first product on sale is the norbiddar (ROPADLAR) of Ropafam corporation in Netherlands, more than ten European and American manufacturers produce the same product, most of the products are chemically synthesized, and the effect is different from that of natural extraction.
At present, the research on natural medicine feed additives for ruminants such as sheep is less at home and abroad [15], so that the research on natural medicine feed additives for sheep has important significance.
The main references:
[1] research progress of herbal feed additives in livestock and poultry [ J ] feed research, 2016, 04: 4-6.
[2] Zhao Wu, application practice of Chinese herbal medicine feed additive in livestock production is found in [ J ] current generation livestock, 2016, 05: 122-123.
[3] The effects of the Hudan and the Rouqiaohong red, the Jianming and the Zhudonghua, the influence of the compound traditional Chinese medicine superfine powder with different dosages on the growth performance and the oxidation resistance of the fattening pigs [ J ]. the livestock and the veterinary, 2015, 47 (9): 107-110.
[4] Equisetum, observation of the effect of feeding goats with Chinese herbal medicine additives of different proportions [ J ]. livestock and veterinarians, 2014, 46 (10): 129-130.
[5] Influence of superfine powder Chinese herbal medicine additive on enzyme, pH value, inorganic ions and HSP70 in serum of heat stress laying hens [ J ] feed industry, 2013, 34 (15): 18-21.
[6] Effect of Zhao Hongmei, Liangming, ultramicro Chinese herbal medicine additive on blood biochemical indicators and hormone levels of weaned piglets [ J ] Chinese feed, 2011, (15): 28-30.
[7] Zhang Shichang, Wang Shi Xiang compound Chinese herbal medicine additive influences the growth performance, oxidation resistance and immune organ index of weaned piglets [ J ] animal husbandry and veterinarians, 2010, 42 (10): 56-59.
[8] Influence of compound Chinese herbal medicine additive on reproductive hormone of ram of Liaoning cashmere goat [ J ] feed industry, 2012, 33 (07): 45-47.
[9] Impact of traditional Chinese medicine superfine powder on immune function of lactating sows [ J ] chinese veterinary science 2014, 44 (02): 205-210.
[10] Influence of the ultrafine powder of the goer wei loyalty, the royal pink, the lukehui, the carbone, the judonghua compound traditional Chinese medicine on the oxidation resistance and the production performance of the broiler [ J ]. the poultry in China, 2015, 37 (22): 62-64.
[11] Lichunyan, Tangdebao, Ganzhengyi, Dougui, Zengziyong, Chinese herbal medicine additive affects sheep growth performance, blood convention and immune function [ J ]. Heilongjiang animal husbandry and veterinary, 2013, 07: 115-118.
[12] Liu Aixia, influence of Chinese herbal medicine additive on milk production performance of dairy goat [ J ]. feed industry, 2013, 34 (13): 58-60.
[13] Study and application of novel green feed additive in ramaria [ J ] jiangxi feed, 2016, 03: 9-10.
[14] Application analysis of the Chinese herbal medicine feed additive in livestock production [ J ] Gansu livestock veterinarian, 2016, 03: 53-54.
[15] The application of Chinese herbal medicine feed additive in cattle and sheep breeding industry [ J ]. contemporary livestock and poultry breeding industry, 2016, 04: 3-4.
Disclosure of Invention
The invention aims to overcome the defects of the prior art, and provides a herbal medicine additive for promoting sheep growth and a preparation and using method thereof, so that the weight gain rate and the resistance to diseases of sheep are improved.
The purpose of the invention is realized by the following technical scheme: a herbal additive for promoting sheep growth is prepared from the following components in percentage by mass:
herba Paederiae 8-10
3.5-5 of the ginseng
Radix cynanchi wilfordii 3.5-5
3.5-5 of bighead atractylodes rhizome
Radix Clerodendri Japonici 1.5-2.5
Broom 1.5-2.5
0.5-1.5 of litsea pungens.
Preferably, the mass ratio of the paederia scandens is 8.6, 9 or 9.2.
Preferably, the mass ratio of the ginseng to the ginseng is 4.0, 4.33 or 4.5, the mass ratio of the cynanchum wilfordii is 3.9, 4.1 or 4.33, and the mass ratio of the bighead atractylodes rhizome is 3.6, 3.9 or 4.33.
Preferably, the mass ratio of the osmunda japonica roots is 2.0, 2.2 or 2.3,
preferably, the mass ratio of the gorse is 1.9, 2.0 or 2.2.
Preferably, the mass ratio of the litsea pungens is 0.6, 1.0 or 1.2.
The preparation method of the herbal additive comprises the following steps:
respectively pulverizing herba Paederiae, radix Codonopsis Pilosulae, radix Cynanchi Wilfordii, Atractylodis rhizoma, radix clerodendri bungei, flos Caraganae Sinicae and fructus Litseae Pungentis, and sieving with 220 mesh sieve of 180 meshes;
mixing herba Paederiae, radix Ginseng, radix Cynanchi Wilfordii, Atractylodis rhizoma, radix clerodendri bungei, flos Caraganae Sinicae and fructus Litseae uniformly at a certain mass ratio.
A method of using an herbal additive comprising: the herbal additive accounting for 0.25-0.8 percent of the total weight of the sheep ration is uniformly mixed with the sheep food and then fed for administration.
Preferably, the frequency of administration of the herbal additive is once daily.
Preferably, the administration time of the herbal additive is 11 months to 3 months in the following year in the south of the Yangtze river, and 11 months to 4 months in the following year in the north of the Yangtze river.
The invention has the beneficial effects that: the invention is composed of Yi nationality common medicines with functions of guiding qi downward and nourishing, has the efficacies of promoting qi circulation, strengthening spleen and tonifying liver and kidney, is suitable for being used in winter with cold climate and lacking of green feed, and can obviously improve the weight gain rate and the resistance to diseases of 3-6 month-old sheep after being continuously used for two months or more.
Drawings
Figure 1 is a graph comparing the effect on sheep weight gain at different doses;
FIG. 2 is a graph comparing the effect of growth hormone on sheep at different doses;
FIG. 3 is a graph comparing the effect of insulin-like growth factor on sheep at different doses;
FIG. 4 is a graph comparing the effect on sheep tetraiodothyronine T4 at different doses;
FIG. 5 is a graph comparing the effect on sheep triiodothyronine T3 at different doses;
FIG. 6 is a graph comparing the effect of IL-2 on sheep at different doses;
FIG. 7 is a graph comparing the effect of IL-6 on sheep at different doses;
figure 8 is a graph comparing the effect of lysozyme on sheep at different doses.
Detailed Description
The technical solutions of the present invention will be described clearly and completely with reference to the following embodiments, and it should be understood that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be obtained by a person skilled in the art without inventive effort based on the embodiments of the present invention, are within the scope of the present invention.
Referring to fig. 1-8, the present invention provides a herbal supplement for promoting sheep growth and methods of making and using the same:
example one
A herbal additive for promoting sheep growth is prepared from the following components in percentage by mass: chinese fevervine herb 9 (Yi medicine name: Yexi ox), oppositional ginseng 4.33 (Yi medicine name: Low glicolor), cynanchum wilfordii 4.33 (Yi medicine name: left period), white atractylodes rhizome 4.33, clerodendranthus bungeana root 2 (Yi medicine name: suction base), gorgonia sinica 2 (Yi medicine name: Ningniuwei), and litsea cubeba 1 (Yi medicine name: stannum).
The preparation method of the herbal additive comprises the following steps: respectively pulverizing herba Paederiae, radix Bidentis Bipinnatae, radix Cynanchi Wilfordii, rhizoma Atractylodis Macrocephalae, radix clerodendri bungei, flos Caraganae Sinicae and fructus Litseae Pungentis, and sieving with 200 mesh sieve; mixing herba Paederiae, radix Ginseng, radix Cynanchi Wilfordii, Atractylodis rhizoma, radix clerodendri bungei, flos Caraganae Sinicae and fructus Litseae in corresponding mass ratio, packaging, sealing, and storing at room temperature in dark.
The use method of the herbal additive comprises the following steps: mixing the herbal additive 0.25 wt% of sheep daily ration with sheep food (such as corn flour, distiller's grains, electrolytic multi-vitamin additive, etc.), and feeding.
The frequency of administration of the herbal additive is once daily.
The administration time of the herbal additive is 11 months to 3 months in the coming year in the south of the Yangtze river, and 11 months to 4 months in the coming year in the north of the Yangtze river.
In the embodiment, the paederia scandens is used as a main drug and is used for promoting qi circulation to promote digestion, enhancing the rumen function of sheep and preventing digestive diseases; the ginseng is used as an adjuvant for enhancing the immunologic function of sheep; radix cynanchi wilfordii is used as an adjuvant for enhancing the digestion, absorption and immunity of sheep; the bighead atractylodes rhizome is used as an adjuvant drug, plays a role in promoting digestion and improving immunity in cooperation with a main drug, utilizes the function of inhibiting various bacteria and fungi, and is used as a natural preservative in the formula; the osmunda japonica root is used for promoting digestion and absorption, and is used as a natural preservative in the formula by utilizing the function of inhibiting various bacteria and fungi; the gorse is used for promoting digestion and absorption and enhancing immunity, and is used as a natural preservative in the formula by utilizing the functions of inhibiting various bacteria and resisting oxidation, so that the effect is good; the litsea cubeba is used for promoting the rumen function of sheep, and the volatile oil of the litsea cubeba can inhibit various bacteria and fungi and has the function of antioxidation, and can be used as a natural preservative in the formula, so the effect is good.
Example two
A herbal additive for promoting sheep growth is prepared from the following components in percentage by mass: paederia scandens 8, radix codonopsis pilosulae 4, cynanchum wilfordii 4.1, bighead atractylodes rhizome 5, clerodendrum bungei root 2.2, gorgon fruit 2.2 and litsea cubeba 1.2.
The preparation method of the herbal additive comprises the following steps: respectively pulverizing herba Paederiae, radix Codonopsis Pilosulae, radix Cynanchi Wilfordii, Atractylodis rhizoma, radix clerodendri bungei, flos Caraganae Sinicae and fructus Litseae, and sieving with 180 mesh sieve; mixing herba Paederiae, radix Ginseng, radix Cynanchi Wilfordii, Atractylodis rhizoma, radix clerodendri bungei, flos Caraganae Sinicae and fructus Litseae in corresponding mass ratio, packaging, sealing, and storing at room temperature in dark.
The use method of the herbal additive comprises the following steps: the herbal additive accounting for 0.5 percent of the total weight of the sheep ration is uniformly mixed with the sheep food and then fed for administration.
The frequency of administration of the herbal additive is once daily.
The administration time of the herbal additive is 11 months to 3 months in the coming year in the south of the Yangtze river, and 11 months to 4 months in the coming year in the north of the Yangtze river.
EXAMPLE III
A herbal additive for promoting sheep growth is prepared from the following components in percentage by mass: 8.6 parts of paederia scandens, 4.5 parts of ginseng, 3.5 parts of cynanchum wilfordii, 3.6 parts of bighead atractylodes rhizome, 2.3 parts of clerodendrum bungei root, 1.5 parts of gorgon fruit and 0.6 part of litsea cubeba.
The preparation method of the herbal additive comprises the following steps: respectively pulverizing herba Paederiae, radix Bidentis Bipinnatae, radix Cynanchi Wilfordii, rhizoma Atractylodis Macrocephalae, radix clerodendri bungei, flos Caraganae Sinicae and fructus Litseae Pungentis, and sieving with 220 mesh sieve; mixing herba Paederiae, radix Ginseng, radix Cynanchi Wilfordii, Atractylodis rhizoma, radix clerodendri bungei, flos Caraganae Sinicae and fructus Litseae in corresponding mass ratio, packaging, sealing, and storing at room temperature in dark.
The use method of the herbal additive comprises the following steps: the herbal additive accounting for 0.35 percent of the total weight of the sheep ration is uniformly mixed with the sheep food and then fed for administration.
The frequency of administration of the herbal additive is once daily.
The administration time of the herbal additive is 11 months to 3 months in the coming year in the south of the Yangtze river, and 11 months to 4 months in the coming year in the north of the Yangtze river.
Example four
A herbal additive for promoting sheep growth is prepared from the following components in percentage by mass: 9.2 parts of paederia scandens, 3.5 parts of radix codonopsis pilosulae, 5 parts of radix cynanchi wilfordii, 3.9 parts of bighead atractylodes rhizome, 2.5 parts of clerodendrum bungei root, 1.9 parts of gorgon fruit and 1.5 parts of litsea cubeba.
The preparation method of the herbal additive comprises the following steps: respectively pulverizing herba Paederiae, radix Codonopsis Pilosulae, radix Cynanchi Wilfordii, Atractylodis rhizoma, radix clerodendri bungei, flos Caraganae Sinicae and fructus Litseae, and sieving with 190 mesh sieve; mixing herba Paederiae, radix Ginseng, radix Cynanchi Wilfordii, Atractylodis rhizoma, radix clerodendri bungei, flos Caraganae Sinicae and fructus Litseae in corresponding mass ratio, packaging, sealing, and storing at room temperature in dark.
The use method of the herbal additive comprises the following steps: the herbal additive accounting for 0.65 percent of the total weight of the sheep ration is uniformly mixed with the sheep food and then fed for administration.
The frequency of administration of the herbal additive is once daily.
The administration time of the herbal additive is 11 months to 3 months in the coming year in the south of the Yangtze river, and 11 months to 4 months in the coming year in the north of the Yangtze river.
EXAMPLE five
A herbal additive for promoting sheep growth is prepared from the following components in percentage by mass: 10 parts of paederia scandens, 5 parts of radix codonopsis pilosulae, 3.9 parts of cynanchum wilfordii, 3.5 parts of bighead atractylodes rhizome, 1.5 parts of clerodendrum bungei root, 2.5 parts of gorgon fruit and 0.5 part of litsea cubeba.
The preparation method of the herbal additive comprises the following steps: respectively pulverizing herba Paederiae, radix Bidentis Bipinnatae, radix Cynanchi Wilfordii, rhizoma Atractylodis Macrocephalae, radix clerodendri bungei, flos Caraganae Sinicae and fructus Litseae, and sieving with 210 mesh sieve; mixing herba Paederiae, radix Ginseng, radix Cynanchi Wilfordii, Atractylodis rhizoma, radix clerodendri bungei, flos Caraganae Sinicae and fructus Litseae in corresponding mass ratio, packaging, sealing, and storing at room temperature in dark.
The use method of the herbal additive comprises the following steps: the herbal additive accounting for 0.8 percent of the total weight of the sheep ration is uniformly mixed with the sheep food and then fed for administration.
The frequency of administration of the herbal additive is once daily.
The administration time of the herbal additive is 11 months to 3 months in the coming year in the south of the Yangtze river, and 11 months to 4 months in the coming year in the north of the Yangtze river.
As shown in figure 1, the addition amount of 0.25-0.8% can improve the weight gain rate of sheep in different degrees within 60 days after the feeding of the herbal additive. Blank (group) was not added, and the low dose was added at 0.25%, the medium dose was added at 0.5% and the high dose was added at 0.8%.
As shown in FIG. 2, the herbal additive of the present invention can promote the secretion of sheep growth hormone and increase its serum concentration. The Growth Hormone (GH) can promote the growth of bones, internal organs and the whole body of animals, promote protein synthesis, influence the metabolism of fat and minerals and play a key role in the growth and development of sheep. The herbal additive of the invention increases the content of sheep serum GH at the administration time of 30 days, and the administration group is significantly different from the blank group at the administration time of 60 days.
As shown in FIG. 3, the herbal additive of the present invention can promote the secretion of sheep I insulin-like growth factor and increase its serum concentration. Insulin-like growth factors (IGFs) are a group of polypeptides with growth-promoting effects, and their secretory cells are widely distributed in tissues such as liver, kidney, lung, heart, brain and intestine of animals. The IGF family includes two types, IGF-I and IGF-II. The production of IGF-I is more dependent on GH, and the growth promoting effect is strong, and is an important growth factor in the young period of sheep. IGF-I synthesized in various tissues plays a role in promoting growth in an autocrine or paracrine manner, and IGF-I synthesized by the liver enters the blood circulation and acts on target cells in an endocrine manner. The IGF-I level in vivo is regulated by GH, and IGF-I also has negative feedback regulation effect on GH secretion. At 30 days and 60 days after the administration of the herbal additive, the herbal additive can obviously improve the IGF-I serum concentration of sheep and has the effect of promoting growth.
As shown in FIGS. 4 and 5, thyroxine (tetraiodothyronine T4) and triiodothyronine (T3) were maintained at higher levels, significantly higher than the blank group, within 30-60d after administration of the herbal additive of the present invention. The thyroid hormone has the most obvious effect of promoting growth and development in the first five months after birth of sheep, and mainly promotes the growth and development of bones, brain and reproductive organs. Meanwhile, the thyroid hormone mainly promotes protein synthesis under normal conditions, particularly obviously increases protein synthesis of bones, skeletal muscles, livers and the like, and has important significance on growth and development of sheep in young period. In the absence of thyroid hormone, the pituitary gland produces and secretes GH less and fails to function. T4 and T3 are a group of tyrosine which takes iodine and tyrosine as raw materials to synthesize iodine in thyroid gland cells, wherein T4 accounts for about 90 percent of the total amount, T3 has less secretion amount but high activity which is 5 times of that of T4, about 50 percent of T4 is deiodinated and converted into T3 every day, and therefore the effect of T3 cannot be ignored. The herbal additive of the invention can up-regulate the concentrations of T4 and T3 in sheep serum after administration, which is consistent with the high level expression of 60dGH after administration, and has synergistic growth promoting effect.
The herbal additive disclosed by the invention can promote the secretion of sheep growth hormone, improve the serum concentration of sheep growth hormone, promote the secretion of sheep I-type insulin-like growth factors, improve the serum concentration of sheep I-type insulin-like growth factors, and up-regulate the concentrations of T4 and T3 in sheep serum, so that the growth of sheep is promoted.
As shown in FIG. 6, the herbal additive of the present invention significantly increased the serum interleukin-2 (IL-2) concentration in sheep 15 days after administration. IL-2 is mainly produced by T lymphocyte system, and can promote proliferation and differentiation of T lymphocyte activated by antigen or mitogen, maintain balance of T cell group (Tc, Ts and Th) of organism, and induce production of various cytokines such as IFN-gamma, IL-4, IL-6 and TNF-beta; simultaneously can induce the differentiation and effect functions of a plurality of killer cells such as CTL, NK, LAK and the like, and induce the killer cells to generate cytokines such as IFN-gamma, TNF-alpha and the like; IL-2 can directly act on B cells to promote proliferation, differentiation and immunoglobulin secretion of the B cells; IL-2 can activate macrophages, enhance the function of phagocytosing foreign bodies and presenting antigens. In conclusion, IL-2 can enhance the cellular immunity (enhance T cell function) and humoral immunity (enhance B cell function) of the body, and the herbal additive of the present invention may have mitogen components, and can activate T cells and B cells of sheep within 30 days after administration, thereby enhancing the immune function.
As shown in FIG. 7, the herbal additive of the present invention significantly increased the serum concentration of sheep interleukin-6 (IL-6) at 60 days of administration. IL-6 is a lymphokine produced by activated T cells and fibroblasts, primarily capable of rendering B cell precursors into antibody-producing cells; and the colony stimulating factor can promote the growth and differentiation of original bone marrow-derived cells and enhance the lysis function of natural killer cells. The herbal additive can gradually increase the serum concentration of IL-6 after being administrated for 30 days, and has the enhancement effect on both cell and humoral immunity of sheep, especially the humoral immunity function of sheep.
As shown in FIG. 8, the herbal additive of the present invention significantly increased the concentration of Lysozyme (LZM) in sheep serum 15 days after administration. LZM is an alkaline enzyme capable of hydrolyzing mucopolysaccharide in pathogenic bacteria, and is an important component of the innate immunity function of sheep. LZM is present in body fluids to lyse bacteria primarily by disrupting the beta-1, 4 glycosidic bond between N-acetylmuramic acid and N-acetylglucosamine in the bacterial cell wall, breaking down the cell wall insoluble mucopolysaccharide into soluble glycopeptides, causing the contents of the broken cell wall to escape. Lysozyme can also be directly combined with virus protein with negative charge, and forms double salt with DNA, RNA and apoprotein to inactivate virus. Therefore, LZM has multiple functions such as antibiosis, antiphlogosis, antivirus, etc. The herbal additive of the invention can significantly improve the anti-infective ability of sheep during the administration period.
The herbal additive can improve the concentration of interleukin-2 (IL-2), the serum concentration of interleukin-6 (IL-6) and the Lysozyme (LZM) in sheep serum, thereby enhancing the immunity of sheep.
The foregoing is illustrative of the preferred embodiments of this invention, and it is to be understood that the invention is not limited to the precise form disclosed herein and that various other combinations, modifications, and environments may be resorted to, falling within the scope of the concept as disclosed herein, either as described above or as apparent to those skilled in the relevant art. And that modifications and variations may be effected by those skilled in the art without departing from the spirit and scope of the invention as defined by the appended claims.
Claims (7)
1. The herbal medicine additive for promoting sheep growth is characterized by being prepared from the following components in parts by mass:
herba Paederiae 8-10
3.5-5 of the ginseng
Radix cynanchi wilfordii 3.5-5
3.5-5 of bighead atractylodes rhizome
Radix Clerodendri Japonici 1.5-2.5
Broom 1.5-2.5
0.5-1.5 of litsea pungens.
2. The herbal supplement for promoting sheep growth as recited in claim 1, wherein the weight ratio of paederia scandens is 8.6, 9 or 9.2.
3. The herbal additive for promoting sheep growth as claimed in claim 1, wherein the mass ratio of radix cynanchi wilfordii to ginseng is 4.0, 4.33 or 4.5, the mass ratio of cynanchum wilfordii is 3.9, 4.1 or 4.33, and the mass ratio of rhizoma atractylodis macrocephalae is 3.6, 3.9 or 4.33.
4. The herbal additive for promoting sheep growth as claimed in claim 1, wherein the mass ratio of the osmunda japonica root is 2.0, 2.2 or 2.3.
5. The herbal supplement for promoting sheep growth as claimed in claim 1, wherein the mass ratio of the broom is 1.9, 2.0 or 2.2.
6. The herbal supplement for promoting sheep growth as claimed in claim 1, wherein the mass ratio of litsea cubeba is 0.6, 1.0 or 1.2.
7. A method of making an herbal additive as claimed in any one of claims 1 to 6, comprising:
respectively pulverizing herba Paederiae, radix Codonopsis Pilosulae, radix Cynanchi Wilfordii, Atractylodis rhizoma, radix clerodendri bungei, flos Caraganae Sinicae and fructus Litseae Pungentis, and sieving with 220 mesh sieve of 180 meshes;
mixing herba Paederiae, radix Ginseng, radix Cynanchi Wilfordii, Atractylodis rhizoma, radix clerodendri bungei, flos Caraganae Sinicae and fructus Litseae uniformly at a certain mass ratio.
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| CN111011616A (en) * | 2019-12-06 | 2020-04-17 | 江苏沿海地区农业科学研究所 | Dairy cow fattening daily ration formula added with sweet sorghum straws |
| CN111616102A (en) * | 2020-06-12 | 2020-09-04 | 孟宪华 | Ecological goat breeding method in mountainous area |
| CN114504061A (en) * | 2022-03-17 | 2022-05-17 | 嘉应学院 | Chicken feed additive and preparation method and application thereof |
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