CN104161209B - A kind of have the feed additive of immunological enhancement, preparation method and application - Google Patents
A kind of have the feed additive of immunological enhancement, preparation method and application Download PDFInfo
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Abstract
The invention discloses and a kind of have the feed additive of immunological enhancement, preparation method and application, this feed additive includes the raw material of following parts by weight: the Radix Astragali 10��25 parts, Radix Isatidis 10��25 parts, the Rhizoma Atractylodis Macrocephalae 10��25 parts, Flos Lonicerae 10��25 parts, Cordyceps polysaccharide 10��20 parts, Radix Saposhnikoviae 5��10 parts, Rhizoma Atractylodis 5��10 parts, transfer factor 3��5 parts. The present invention is by Cordyceps polysaccharide, the Radix Astragali, Radix Isatidis, the Rhizoma Atractylodis Macrocephalae, Flos Lonicerae, Radix Saposhnikoviae, the composite Chinese medicine composition of making of Rhizoma Atractylodis, then is mixed to get the feed additive of the present invention with transfer factor. The feed additive safety non-toxic of the present invention, green noresidue, it is possible to strengthen the immunocompetence of poultry, effectively prevent and treat the bacillary of poultry and viral disease, and can increase piglet feed intake, promote piglet growth, improve growth performance and the feedstuff-meat ratio of piglet.
Description
Technical field
The present invention relates to a kind of feed additive with immunological enhancement, also relate to preparation method and the application of this feed additive, belong to animal feed additive field.
Background technology
Animal diseases are one of key factors of harm animal survival and development. Virus and antibacterial mainly encroach on the immune system of poultry: virus and antibacterial and macrophage, mononuclear cell, histiocyte, core thymus macrophage accompany, cause immunosuppressant, and then causing immunodeficiency, its clinical manifestation is: the microorganism of low pathogenicity or attenuated vaccine can be diseases induced; Repeat to fall ill to treatment unresponsiveness; Vaccination is not had abundant immunne response; There are the situations such as multiple diseases complex generation simultaneously.
Currently for viral and bacterial disease mainly so that An ounce of prevention is worth a pound of cure. And existence undesirable for the most effect of prophylactic vaccine dissipates the danger of poison, adopt antimicrobial drug, such as florfenicol, gentamycin and sulfa drugs etc., it is easy to produce drug residue and drug resistance, and antiviral agents such as ribavirin, amantadine etc. are disabled by the Ministry of Agriculture.
Chinese herbal feed additive have environmental protection, aboundresources, without Drug resistance and polyfunctional advantage, enhancing development, promote the price of deed, antibacterial, worm-expelling, antiviral, enhancing immunity, prevention epidemic disease, improve produce performance, reduce the quality that animal product and stress be improved in effect be closely confirmed. But lack at present and use, pharmaceutics, pharmacological principle to study working in coordination with and antagonism in anti-bacteria and anti-virus, raising immunity of organisms between each medicinal herb components targetedly, often result in that compatibility not science, action effect be unstable, additive capacity crosses high weak point, limit the application of Chinese herbal feed additive to a certain extent.
Summary of the invention
It is an object of the invention to provide a kind of feed additive with immunological enhancement, it is possible to enhancing human body immunity power, promote the growth promoter of pig.
In order to realize object above, the technical solution adopted in the present invention is to provide a kind of feed additive with immunological enhancement, and described feed additive includes the raw material of following parts by weight: the Radix Astragali 10��25 parts, Radix Isatidis 10��25 parts, the Rhizoma Atractylodis Macrocephalae 10��25 parts, Flos Lonicerae 10��25 parts, Cordyceps polysaccharide 10��20 parts, Radix Saposhnikoviae 5��10 parts, Rhizoma Atractylodis 5��10 parts, transfer factor 3��5 parts.
Preferably, described feed additive includes the raw material of following parts by weight: the Radix Astragali 20 parts, Radix Isatidis 15 parts, the Rhizoma Atractylodis Macrocephalae 10 parts, Flos Lonicerae 20 parts, Cordyceps polysaccharide 15 parts, Radix Saposhnikoviae 5 parts, Rhizoma Atractylodis 5 parts, transfer factor 3 parts.
Transfer factor of the present invention is commercially available routine transfer factor powder for animals (4% content).
The effect of each raw material in feed additive of the present invention:
Transfer factor: transfer factor is a kind of factor that can shift sensitization information in the multiple factor having immunocompetent T lymphocyte to discharge in leukocyte, the function of a certain for donor cellular immunization can be transferred to receptor by specifically, non-specifically strengthen recipient immune function, excitating organism specificity and nonspecific immunity, induction of lymphocyte and phagocyte, at the local cluster of site of pathological change, act on thus having played infection and antitumor etc.; The immunologic function with enhancing body can be repaired, improve the premunition of body, reduce immunosuppressant, immunological paralysis, immunological incompetence and also can reduce immunological stress and other ratios that stress occur; Will not being decomposed by pepsin, trypsin, destroy without by gastric acid, without species specificity, have no side effect, applying flexible is convenient, is applied in livestock and poultry pestilence preventing and treating and achieves good therapeutic effect.
Cordyceps polysaccharide: one of main active of Cordyceps, it is possible to activated macrophage stimulates antibody to produce, and improves immunity of organisms, additionally has and improve respiratory system, it is suppressed that tumor growth, anti-stress, the pharmacological action such as blood sugar lowering and slow down aging.
The Radix Astragali: sweet in the mouth, feeble QI temperature, gas is thin and taste is dense, can rise and can drop, and the yang aspect of yang is also, nontoxic. Return lung, spleen, liver, kidney channel. There is enhancing human body immunity function and hemopoietic function, improve substance metabolism, the effect such as anti-stress and antiviral. Weak for the deficiency of vital energy, anorexia and loose stool, sinking of QI of middle-JIAO, chronic diarrhea proctoptosis, metrorrhagia of having blood in stool, exterior deficiency spontaneous perspiration, carbuncle difficulty is burst, and bursts for a long time and does not hold back, and blood deficiency and yellow complexion, interior-heat is quenched one's thirst.
Radix Isatidis: bitter, cold, cool, nontoxic. Return liver, stomach warp. There is heat clearing away, antibacterial, antiviral, removing heat from blood, sore-throat relieving effect. Cure mainly anemopyretic cold, laryngopharynx swelling and pain, skin ulcer general edema with yellowish skin poison etc.
The Rhizoma Atractylodis Macrocephalae: sweet in the mouth, hardship, warm in nature. Enter spleen, stomach warp. With in, dampness, diuretic, invigorating the spleen and benefiting QI, assist Radix Astragali strengthening superficial resistance to stop perspiration. Cure mainly: the few abdominal distention of deficiency-weakness of spleen-QI, spiritlessness and weakness, lack of appetite, big loose stool are thin, fluid-retention stagnating in the interior, dysuria, edema etc.
Flos Lonicerae: the sweet cold fragrance of property, has the effects such as antibacterial, antiinflammatory, antipyretic, enhancing immunity and antiendotoxin, and for heat-clearing and toxic substances removing, diuresis is induced sweat.
Radix Saposhnikoviae: acrid in the mouth, sweet, slightly warm in nature. Enter spleen channel, lung meridian, Liver Channel, bladder warp. Expelling pathogenic wind from the body surface, removing dampness to relieve pain, spasmolytic, the effect such as antipruritic. Curing mainly affection of exogenous wind-cold, general pain of having a headache, rheumatic arthralgia, joint is ached, and stomachache is had loose bowels.
Rhizoma Atractylodis: acrid, bitter, warm. Return spleen, stomach, Liver Channel. Have drying damp and strengthening spleen, expelling wind and cold, antibacterial antitumor, the effect such as improving eyesight. For treating distension and fullness in the abdomen, edema of having loose bowels, anemofrigid cold, nyctalopia etc.
The Chinese medicine ingredients such as Flos Lonicerae in the present invention, Radix Isatidis, Folium Isatidis are as antiviral drugs, the propagation of virus can be suppressed fast and effectively in body, and the Chinese medicine ingredients such as Cordyceps polysaccharide, the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, Radix Saposhnikoviae can reduce stress, enhancing human body immunity function, transfer factor is the important factor of cell immune response, regulate and improve the immune function of body, these immunostimulants and antiviral drugs use in conjunction, be conducive to the removing of virus.The feed additive safety non-toxic of the present invention, green noresidue, it is possible to strengthen the immunocompetence of poultry, effectively prevent and treat the bacillary of poultry and viral disease, and can increase piglet feed intake, promote piglet growth, improve growth performance and the feedstuff-meat ratio of piglet.
The present invention also aims to the preparation method that a kind of feed additive with immunological enhancement is provided.
The technical solution adopted in the present invention also resides in the preparation method providing a kind of feed additive with immunological enhancement, comprises the following steps:
1) Radix Astragali, Radix Isatidis, the Rhizoma Atractylodis Macrocephalae, Flos Lonicerae, Radix Saposhnikoviae, Rhizoma Atractylodis are pulverized and sieved respectively net;
2) weigh the Radix Astragali after sieving, Radix Isatidis, the Rhizoma Atractylodis Macrocephalae, Flos Lonicerae, Radix Saposhnikoviae, Rhizoma Atractylodis in proportion, mix homogeneously with Cordyceps polysaccharide;
3) add transfer factor mix homogeneously and get final product.
Described screen cloth is 600-800 order.
The present invention, by the Radix Astragali, Radix Isatidis, the Rhizoma Atractylodis Macrocephalae, Flos Lonicerae, Radix Saposhnikoviae, Rhizoma Atractylodis micronizing, substep mixing, allows medicament to mix homogeneously, improves bioavailability. It addition, the preparation method of feed additive of the present invention is simple, raw material sources are extensive, it is easy to industrialization promotion.
The present invention also aims to provide a kind of feed additive to have the application in the feedstuff of immunological enhancement in preparation.
The technical solution adopted in the present invention also resides in provides a kind of feed additive to have the application in the feedstuff of immunological enhancement in preparation.
The feed additive of a small amount of present invention is added in feedstuff and can play enhancing human body immunity power, effectively prevention and treatment livestock and poultry pestilence, and promote the effect of the growth promoter of pig.
Detailed description of the invention
Transfer factor of the present invention is transfer factor powder for animals (4% content), purchased from Shijiazhuang and sincere Bioisystech Co., Ltd.
Embodiment 1
The feed additive with immunological enhancement of the present embodiment, including the raw material of following parts by weight: the Radix Astragali 10 parts, Radix Isatidis 10 parts, the Rhizoma Atractylodis Macrocephalae 25 parts, Flos Lonicerae 10 parts, Cordyceps polysaccharide 20 parts, Radix Saposhnikoviae 5 parts, Rhizoma Atractylodis 5 parts, transfer factor 3 parts.
The preparation method of the feed additive with immunological enhancement of the present embodiment, comprises the following steps:
1) Radix Astragali, Radix Isatidis, the Rhizoma Atractylodis Macrocephalae, Flos Lonicerae, Radix Saposhnikoviae, Rhizoma Atractylodis were pulverized 800 eye mesh screens respectively;
2) weigh the Radix Astragali after sieving, Radix Isatidis, the Rhizoma Atractylodis Macrocephalae, Flos Lonicerae, Radix Saposhnikoviae, Rhizoma Atractylodis in proportion, mix homogeneously with Cordyceps polysaccharide;
3) add transfer factor mix homogeneously and get final product.
Embodiment 2
The feed additive with immunological enhancement of the present embodiment, including the raw material of following parts by weight: the Radix Astragali 20 parts, Radix Isatidis 20 parts, the Rhizoma Atractylodis Macrocephalae 10 parts, Flos Lonicerae 20 parts, Cordyceps polysaccharide 15 parts, Radix Saposhnikoviae 8 parts, Rhizoma Atractylodis 8 parts, transfer factor 4 parts.
The preparation method of the feed additive with immunological enhancement of the present embodiment, comprises the following steps:
1) Radix Astragali, Radix Isatidis, the Rhizoma Atractylodis Macrocephalae, Flos Lonicerae, Radix Saposhnikoviae, Rhizoma Atractylodis were pulverized 700 eye mesh screens respectively;
2) weigh the Radix Astragali after sieving, Radix Isatidis, the Rhizoma Atractylodis Macrocephalae, Flos Lonicerae, Radix Saposhnikoviae, Rhizoma Atractylodis in proportion, mix homogeneously with Cordyceps polysaccharide;
3) add transfer factor mix homogeneously and get final product.
Embodiment 3
The feed additive with immunological enhancement of the present embodiment, including the raw material of following parts by weight: the Radix Astragali 25 parts, Radix Isatidis 25 parts, the Rhizoma Atractylodis Macrocephalae 15 parts, Flos Lonicerae 25 parts, Cordyceps polysaccharide 10 parts, Radix Saposhnikoviae 10 parts, Rhizoma Atractylodis 10 parts, transfer factor 5 parts.
The preparation method of the feed additive with immunological enhancement of the present embodiment, comprises the following steps:
1) Radix Astragali, Radix Isatidis, the Rhizoma Atractylodis Macrocephalae, Flos Lonicerae, Radix Saposhnikoviae, Rhizoma Atractylodis were pulverized 600 eye mesh screens respectively;
2) weigh the Radix Astragali after sieving, Radix Isatidis, the Rhizoma Atractylodis Macrocephalae, Flos Lonicerae, Radix Saposhnikoviae, Rhizoma Atractylodis in proportion, mix homogeneously with Cordyceps polysaccharide;
3) add transfer factor mix homogeneously and get final product.
Embodiment 4
The feed additive with immunological enhancement of the present embodiment, including the raw material of following parts by weight: the Radix Astragali 20 parts, Radix Isatidis 15 parts, the Rhizoma Atractylodis Macrocephalae 10 parts, Flos Lonicerae 20 parts, Cordyceps polysaccharide 15 parts, Radix Saposhnikoviae 5 parts, Rhizoma Atractylodis 5 parts, transfer factor 3 parts.
The preparation method of the feed additive with immunological enhancement of the present embodiment, comprises the following steps:
1) Radix Astragali, Radix Isatidis, the Rhizoma Atractylodis Macrocephalae, Flos Lonicerae, Radix Saposhnikoviae, Rhizoma Atractylodis were pulverized 800 eye mesh screens respectively;
2) weigh the Radix Astragali after sieving, Radix Isatidis, the Rhizoma Atractylodis Macrocephalae, Flos Lonicerae, Radix Saposhnikoviae, Rhizoma Atractylodis in proportion, mix homogeneously with Cordyceps polysaccharide;
3) add transfer factor mix homogeneously and get final product.
Experimental example 1
Pig is produced the impact of performance by feed additive of the present invention
Normal diet used by this experimental example is commercially available conventional feed.
1) for examination animal: adopting single-factor 4 level design, adopt 35 age in days Chang-Bai piglet 120, be randomly divided into 4 groups, male and female has concurrently, and the pig individual weight selected and the mental status are similar. Feeding method adopts group feeding, every day 3 times, freely drinks water. Recording the feed intake often organizing pig and swinery situation during test respectively, morning every day weighs and record on an empty stomach.
2) using method: set test group and matched group, matched group uses commercially available normal diet, and every day feeds for 3 times; The test group feed additive that example 0.2%, 0.3%, the 0.4% interpolation embodiment of the present invention 4 is made in mass ratio in normal diet, feeds by matched group method.
3) test period: on June 1st, 2012 to July 30.
4) result of the test is in Table 1.
The impact on Production Performance of Weaning Pigs of the feed additive of table 1 present invention
Table 1 result shows:
1) test group adding mass fraction 0.2%, 0.3% and 0.4% feed additive all increases than matched group in end weight, daily gain and daily ingestion amount, especially with addition be 0.4% feed additive test group notable.
2) addition be 0.4% feed additive test group feedstuff-meat ratio improve 3.3%, 1.6% and 6.5% than the test group of addition 0.2%, 0.3% and matched group respectively, addition be 0.2% and 0.3% feed additive test group also increase than matched group.
Experimental example 2
Pig is produced the impact of performance by feed additive of the present invention
Normal diet used by this experimental example is commercially available conventional feed.
1) for examination animal: adopting single-factor 4 level design, adopt 35 age in days Chang-Bai piglet 210, be randomly divided into 7 groups, male and female has concurrently, and the pig individual weight selected and the mental status are similar. Feeding method adopts group feeding, every day 3 times, freely drinks water. Recording the feed intake often organizing pig and swinery situation during test respectively, morning every day weighs and record on an empty stomach.
2) using method: set test group and matched group, matched group 1 uses commercially available normal diet, and every day feeds for 3 times; The 4% content transfer factor powder that matched group 2 uses commercially available normal diet+mass ratio to be 0.4%, every day feeds for 3 times; The Chinese medicine composition (Radix Astragali 25 parts, Radix Isatidis 10 parts, the Rhizoma Atractylodis Macrocephalae 25 parts, Flos Lonicerae 25 parts, Cordyceps polysaccharide 10 parts, Radix Saposhnikoviae 8 parts, Rhizoma Atractylodis 10 parts) that matched group 3 uses commercially available normal diet+mass ratio to be 0.4%, every day feeds for 3 times;Test group adds the feed additive that the embodiment of the present invention 1,2,3,4 is made respectively in normal diet, and example is 0.4% interpolation in mass ratio, feeds by matched group method.
3) test period: on June 1st, 2012 to July 30.
4) result of the test is in Table 2.
The impact on Production Performance of Weaning Pigs of the feed additive of table 2 present invention
| First starting weight/kg | End weight/kg | Daily gain/kg | Daily ingestion amount/g | Feedstuff-meat ratio | |
| Embodiment 1 | 7.43��0.76 | 29.86��2.42 | 0.37��0.05 | 884��56.32 | 2.36:1 |
| Embodiment 2 | 7.45��0.86 | 31.63��2.42 | 0.40��0.08 | 872��56.32 | 2.16:1 |
| Embodiment 3 | 7.44��0.81 | 33.89��2.85 | 0.44��0.05 | 889��58.52 | 2.05:1 |
| Embodiment 4 | 7.43��0.83 | 35.32��2.93 | 0.46��0.06 | 890��54.36 | 1.91:1 |
| Matched group 1 | 7.45��0.84 | 25.52��2.65 | 0.30��0.07 | 821��53.26 | 2.73:1 |
| Matched group 2 | 7.41��0.74 | 27.38��2.53 | 0.33��0.06 | 845��53.26 | 2.54:1 |
| Matched group 3 | 7.44��0.53 | 28.20��2.35 | 0.35��0.04 | 858��52.65 | 2.48:1 |
Table 2 result shows:
1) test group of feed additive of the present invention adding mass fraction 0.4% is all significantly improved than matched group 1,2,3 groups in daily gain and feedstuff-meat ratio, especially with addition be 0.4% embodiment 4 test group the most notable.
2) matched group 2 is the 4% content transfer factor powder using commercially available normal diet+mass ratio to be 0.4%, without Chinese medicine composition; By result of the test it can be seen that compared with embodiment 4, daily gain have dropped about 0.13kg, and feedstuff-meat ratio dramatically increases, further illustrate and between transfer factor and Chinese medicine composition, there is cooperative effect, the two rational proportion, it is possible to significantly improve livestock and poultry production performance.
3) matched group 3 uses commercially available normal diet+mass ratio to be the Chinese medicine composition of 0.4%, and without transfer factor; Be can be seen that by result of the test, matched group 3 all has a degree of improvement than matched group 1 in daily gain and feedstuff-meat ratio, but the embodiment 1-4 that effect is obviously composite with Chinese medicine composition not as employing transfer factor, illustrate to exist between transfer factor and Chinese medicine composition cooperative effect, the two rational proportion, it is possible to significantly improve livestock and poultry production performance.
Experimental example 3
The impact on pig immunologic function of the feed additive of the present invention
Normal diet used by this experimental example is commercially available conventional feed.
1) for examination animal: adopting single-factor 4 level design, adopt 35 age in days Chang-Bai piglet 210, be randomly divided into 7 groups, male and female has concurrently, and the pig individual weight selected and the mental status are similar. Feeding method adopts group feeding, every day 3 times, freely drinks water.
2) using method: set test group and matched group, matched group 1 uses commercially available normal diet, and every day feeds for 3 times; The 4% content transfer factor powder that matched group 2 uses commercially available normal diet+mass ratio to be 0.4%, every day feeds for 3 times; The Chinese medicine composition (Radix Astragali 25 parts, Radix Isatidis 10 parts, the Rhizoma Atractylodis Macrocephalae 25 parts, Flos Lonicerae 25 parts, Cordyceps polysaccharide 10 parts, Radix Saposhnikoviae 8 parts, Rhizoma Atractylodis 10 parts) that matched group 3 uses commercially available normal diet+mass ratio to be 0.4%, every day feeds for 3 times; Test group adds the feed additive that the embodiment of the present invention 1,2,3,4 is made respectively in normal diet, and example is 0.4% interpolation in mass ratio, feeds by matched group method.
3) test period: on August 15th, 2012 to October 13.
4) project is measured: from often group, randomly choose 20 piglets, male and female half and half, totally 140. Gather 10ml vena cava anterior blood, take the 2ml heparin anti-coagulating mensuration for t lymphocyte subset group (CD3, CD4, CD8) quantity, lymphocyte positive rate. The serum separated is used for measuring interleukin II (IL-2), gamma interferon content. Lymphocyte positive rate adopts acid ��-acetic acid naphthalene lipase Determination Staining. IL-2, gamma interferon content are detected by ELISA method. IL-2, gamma interferon detection kit provide by U.S. MARKET.Adopt the quantity of U.S.'s Coulter company EPICS-XL flow cytomery T lymphocyte subsets.
5) result of the test is in Table 3.
The impact on ablactational baby pig immunologic function of the feed additive of table 3 present invention
From table 3 result of the test it can be seen that
1) add the IL-2 of test group of mass fraction 0.4% embodiment 1,2,3,4 feed additive, gamma interferon, lymphocyte positive rate, CD4/CD8 value all increase than matched group, especially with addition be 0.4% embodiment 4 test group the most notable.
2) matched group 2 is the 4% content transfer factor powder using commercially available normal diet+mass ratio to be 0.4%, and without Chinese medicine composition; Be can be seen that by result of the test, compared with embodiment 4, CD4/CD8 value have dropped about 0.061%, and lymphocyte positive rate declines 1.4%, IL-2 have dropped about 0.80pg at the content of every milliliter of serum, and gamma interferon have dropped about 2.71pg at the content of every milliliter of serum. Further illustrate individually add transfer factor reasonably combined with both Chinese medicine compositions with transfer factor compared with, significant difference in improving poultry body's immunity.
3) matched group 3 uses commercially available normal diet+mass ratio to be the Chinese medicine composition of 0.4%, and without transfer factor; Be can be seen that by result of the test, matched group 3 is compared with matched group 1, a degree of improvement is all had in IL-2, gamma interferon, lymphocyte positive rate, CD4/CD8 value, but the embodiment 1-4 that effect is obviously composite with Chinese medicine composition not as employing transfer factor, illustrates that the present invention adopts transfer factor to have significant effect with Chinese medicine composition is composite.
Claims (5)
1. a feed additive with immunological enhancement, it is characterized in that, described feed additive is made up of the raw material of following parts by weight: the Radix Astragali 10��25 parts, Radix Isatidis 10��25 parts, the Rhizoma Atractylodis Macrocephalae 10��25 parts, Flos Lonicerae 10��25 parts, Cordyceps polysaccharide 10��20 parts, Radix Saposhnikoviae 5��10 parts, Rhizoma Atractylodis 5��10 parts, transfer factor 3��5 parts.
2. a kind of feed additive with immunological enhancement according to claim 1, it is characterized in that, described feed additive is made up of the raw material of following parts by weight: the Radix Astragali 20 parts, Radix Isatidis 15 parts, the Rhizoma Atractylodis Macrocephalae 10 parts, Flos Lonicerae 20 parts, Cordyceps polysaccharide 15 parts, Radix Saposhnikoviae 5 parts, Rhizoma Atractylodis 5 parts, transfer factor 3 parts.
3. the preparation method of a feed additive as claimed in claim 1 with immunological enhancement, it is characterised in that comprise the following steps:
1) Radix Astragali, Radix Isatidis, the Rhizoma Atractylodis Macrocephalae, Flos Lonicerae, Radix Saposhnikoviae, Rhizoma Atractylodis are pulverized and sieved respectively net;
2) weigh the Radix Astragali after sieving, Radix Isatidis, the Rhizoma Atractylodis Macrocephalae, Flos Lonicerae, Radix Saposhnikoviae, Rhizoma Atractylodis in proportion, mix homogeneously with Cordyceps polysaccharide;
3) add transfer factor mix homogeneously and get final product.
4. the preparation method of a kind of feed additive with immunological enhancement according to claim 3, it is characterised in that described screen cloth is 600-800 order.
5. a feed additive as claimed in claim 1 has the application in the feedstuff of immunological enhancement in preparation.
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| CN105146081A (en) * | 2015-08-26 | 2015-12-16 | 蚌埠市蚌山区常宝养猪场 | Feed additive special for piglets and preparation method thereof |
| CN106107042A (en) * | 2016-07-19 | 2016-11-16 | 云南金碑康康生态科技有限公司 | Antiviral feedstuff for live pigs |
| CN106578494A (en) * | 2016-10-31 | 2017-04-26 | 南宁市美嘉农饲料有限责任公司 | Plant type feed additive for improving immunity of live pigs |
| CN107412738A (en) * | 2017-08-29 | 2017-12-01 | 深圳依可立康生物技术有限公司 | A kind of nutritive cream for treating the viral anemofrigid cold of pet and preparation method thereof |
| CN109984255B (en) * | 2019-04-29 | 2022-06-21 | 吉林省正合生物技术有限公司 | Antitoxic immunopotentiating peptide compound microbial feed additive and preparation method thereof |
| CN110074280A (en) * | 2019-05-28 | 2019-08-02 | 濉溪县绿安生物饲料有限公司 | A kind of pannage and preparation method thereof that premunition can be improved |
| CN110250335A (en) * | 2019-06-27 | 2019-09-20 | 江西派尼生物药业有限公司 | A kind of improvement animal immune the Chinese herbal medicine extract and its preparation method and application |
| CN111700154A (en) * | 2020-03-25 | 2020-09-25 | 四川铁骑力士实业有限公司 | Immunity-enhancing feed additive for growing pigs and application thereof |
| CN114209769B (en) * | 2021-12-30 | 2023-03-24 | 河南金大众生物工程有限公司 | Natural plant composition for improving animal immunity and application thereof |
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| CN102793792B (en) * | 2012-08-23 | 2013-10-23 | 郑州后羿制药有限公司 | Traditional Chinese medicine composition for treating porcine circovirus disease and preparation method thereof |
| CN103168919B (en) * | 2013-04-07 | 2014-04-02 | 四川汇博兽药科技有限公司 | Feed additive for enhancing immunity and promoting growth and feed |
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