CN104161209A - Feed additive with immunity enhancement function, preparation method and application thereof - Google Patents
Feed additive with immunity enhancement function, preparation method and application thereof Download PDFInfo
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Abstract
The invention discloses a feed additive with immunity enhancement function, a preparation method and an application thereof. The feed additive comprises the following raw materials in parts by weight: Milkvetch root 10-25, isatis root 10-25, Rhizoma Atractylodis 10-25, honeysuckle flower 10-25, Cordyceps Polysaccharide 10-20, Divaricate Saposhnikovia root 5-10, Atractylodes Rhizome 5-10, and transfer factor 3-5. The Milkvetch root, isatis root, Rhizoma Atractylodis, honeysuckle flower, Cordyceps Polysaccharide, Divaricate Saposhnikovia root and Atractylodes Rhizome are compounded to form a traditional Chinese medicine composite, and then the traditional Chinese medicine composite is mixed with the transfer factor to obtain the feed additive. The feed additive is safe, non-toxic, and environmentally friendly without residues. The feed additive can enhance the immunity of livestock and poultry, effectively prevent and treat bacterial and viral diseases of livestock and poultry, increase the feed intake of piglets, promote the growth of piglets, and improve the growth performance of piglets and the feed conversion ratio.
Description
Technical field
The present invention relates to a kind of feed addictive with immunological enhancement, also relate to preparation method and the application of this feed addictive simultaneously, belong to animal feed additive field.
Background technology
Animal diseases are one of key factors of harm animal survival and development.Virus and bacterium mainly encroach on the immune system of livestock and poultry: virus and bacterium and macrophage, monocyte, histocyte, core thymus gland macrophage accompany, cause immunosupress, and then causing immune deficiency, its clinical manifestation is: the microorganism of low pathogenicity or attenuated vaccine can be diseases induced; Repeat morbidity to treatment unresponsiveness; Vaccine inoculation is not had to abundant immune response; There are the situations such as various diseases syndrome generation simultaneously.
At present, for viral and bacteriosis mainly so that An ounce of prevention is worth a pound of cure.Undesirable and the loose malicious danger of existence for the most effect of prophylactic vaccine, adopt antimicrobial, as Florfenicol, gentamicin and sulfa drugs etc., easily produce medicament residue and drug resistance, and antiviral agent is forbidden as Ribavirin, amantadine etc. by the Ministry of Agriculture.
Chinese herbal feed additive has environmental protection, aboundresources, without the resistance to the action of a drug and polyfunctional advantage, enhancing development, promote the price of deed, antibacterial, worm-expelling, antiviral, strengthen immunity, prevention epidemic disease, improve production performance, the effect that reduces aspect quality that stress and improve animal product is closely confirmed.Use, pharmacy, pharmacology principle to study targetedly the collaborative and antagonism aspect anti-bacteria and anti-virus, raising immunity of organisms between each medicinal herb components but lack at present, often cause compatibility not unstable, the additive capacity of science, action effect cross high weak point, limited to a certain extent the application of Chinese herbal feed additive.
Summary of the invention
The object of this invention is to provide a kind of feed addictive with immunological enhancement, can strengthen immunity of organisms, promote growing of pig.
In order to realize above object, the technical solution adopted in the present invention is to provide a kind of feed addictive with immunological enhancement, and described feed addictive comprises the raw material of following parts by weight: 10～25 parts of the Radixs Astragali, 10～25 parts of Radix Isatidis, 10～25 parts of the bighead atractylodes rhizomes, 10～25 parts of honeysuckles, 10～20 parts of Cordyceps sinensis polysaccharides, windproof 5～10 parts, 5～10 parts of rhizoma atractylodis, 3～5 parts of transfer factor.
Preferably, described feed addictive comprises the raw material of following parts by weight: 20 parts of the Radixs Astragali, 15 parts of Radix Isatidis, 10 parts of the bighead atractylodes rhizomes, 20 parts of honeysuckles, 15 parts of Cordyceps sinensis polysaccharides, windproof 5 parts, 5 parts of rhizoma atractylodis, 3 parts of transfer factor.
Transfer factor of the present invention is commercially available routine transfer factor powder for animals (4% content).
The effect of each raw material in feed addictive of the present invention:
Transfer factor: transfer factor is to have a kind of factor that can shift sensitization information in the multiple factor that immunocompetent T lymphocyte discharges in leucocyte, it can be transferred to acceptor by the function of a certain cellular immunity of donor specifically, non-specifically strengthen and be subject to body immunity function, excitating organism specificity and nospecific immunity, induction of lymphocyte and phagocyte be at the local cluster of site of pathological change, thereby brought into play the effects such as anti-infective and antitumor; Can repair and strengthen the immunologic function of body, improve the premunition of body, reduce immunosupress, immunological paralysis, immunological incompetence and can reduce immunological stress and other ratios that stress occur; Can do not decomposed by pepsin, trypsase, also can, by stomach acids destroy, without species specificity, not have no side effect, applying flexible is convenient, is applied in livestock and poultry pestilence control and has obtained good result for the treatment of.
Cordyceps sinensis polysaccharide: one of main active of Cordyceps sinensis, can activated macrophage stimulate antibody to produce, improve immunity of organisms, there is in addition the respiratory system of improvement, suppress tumor growth, anti-stress, the pharmacological action such as hypoglycemic and delay senility.
The Radix Astragali: taste is sweet, gas tepor, gas is thin and taste is dense, can rise to fall, and the yang aspect of yang is also, nontoxic.Return lung, spleen, liver, kidney channel.There is enhanced machine body immunity function and hematopoiesis function, improve metabolism, anti-stress with the effect such as antiviral.Weak for the deficiency of vital energy, anorexia and loose stool, the sinking of qi of middle-jiao, rushes down prolapse of the anus for a long time, the uterine bleeding of having blood in stool, exterior deficiency spontaneous perspiration, ulcer is difficult bursts, and bursts and does not hold back for a long time, and the deficiency of blood is sallow, and interior heat is quenched one's thirst.
Radix Isatidis: hardship, cold, cool, nontoxic.Return liver, stomach warp.There is heat-clearing, antibacterial, antiviral, cool blood, relieve sore throat effect.Cure mainly anemopyretic cold, abscess of throat, the yellow pyogenic infections of sore etc.
The bighead atractylodes rhizome: taste is sweet, bitter, warm in nature.Enter spleen, stomach warp.With in, eliminating dampness, Li Shui, strengthening the spleen and replenishing qi, assists Radix Astragali strengthening exterior and reducing sweat.Cure mainly: deficiency-weakness of spleen-QI, spiritlessness and weakness, food be thin, the fluid retention stagnating in the interior of abdominal distension, large loose stool, difficult urination, oedema etc. less.
Honeysuckle: the sweet cold air fragrance of property, have antibacterial, anti-inflammatory, antipyretic, strengthen the effects such as immunity and antiendotoxin, for clearing heat and detoxicating, diuresis is induced sweat.
Windproof: taste is pungent, sweet, slightly warm in nature.Enter the spleen channel, lung channel, Liver Channel, urinary bladder channel.Expel pathogenic wind from the body surface, removing dampness to relieve pain, spasmolysis, the effect such as antipruritic.Cure mainly and catch cold, headache bodily pain, arthralgia due to wind-dampness, joint is ached, and stomachache is had loose bowels etc.
Rhizoma atractylodis: acrid, bitter, warm.Return spleen, stomach, Liver Channel.Have drying damp and strengthening spleen, expelling wind and clearing away cold, antibacterial antitumor, the effects such as improving eyesight.Be used for the treatment of abdominal fullness and distention, the oedema of having loose bowels, anemofrigid cold, yctalopia etc.
The traditional Chinese medicine ingredients such as honeysuckle in the present invention, Radix Isatidis, folium isatidis are as antiviral drugs, in body, can suppress fast and effectively viral propagation, and Cordyceps sinensis polysaccharide, the Radix Astragali, the bighead atractylodes rhizome, the traditional Chinese medicine ingredients such as windproof can reduce stress, enhanced machine body immunity function, transfer factor is the important factor of cell immune response, the immunity function that regulates and improve body, these immunopotentiators and antiviral drugs use in conjunction, be conducive to viral removing.Feed addictive safety non-toxic of the present invention, green noresidue, can strengthen the immunocompetence of fowl poultry, effectively prevents and treats the bacillary and viral disease of fowl poultry, and can increase piglet feed intake, promotes piglet growth, improves growth performance and the feedstuff-meat ratio of piglet.
The present invention also aims to provide a kind of preparation method of the feed addictive with immunological enhancement.
The technical solution adopted in the present invention is also to provide a kind of preparation method of the feed addictive with immunological enhancement, comprises the following steps:
1) Radix Astragali, Radix Isatidis, the bighead atractylodes rhizome, honeysuckle, windproof, rhizoma atractylodis are pulverized and sieved respectively to net;
2) take in proportion the Radix Astragali, Radix Isatidis, the bighead atractylodes rhizome, honeysuckle, windproof, the rhizoma atractylodis after sieving, mix with Cordyceps sinensis polysaccharide;
3) add again transfer factor to mix and get final product.
Described screen cloth is 600-800 order.
The present invention is by the Radix Astragali, Radix Isatidis, the bighead atractylodes rhizome, honeysuckle, windproof, rhizoma atractylodis ultramicro grinding, and substep mixes, and medicine can be mixed, and has improved bioavilability.In addition, the preparation method of feed addictive of the present invention is simple, raw material sources are extensive, is easy to industrialization promotion.
The present invention also aims to provide a kind of feed addictive to there is the application in the feed of immunological enhancement in preparation.
The technical solution adopted in the present invention is also to provide a kind of feed addictive to have the application in the feed of immunological enhancement in preparation.
A small amount of feed addictive of the present invention is added in feed and can play enhancing immunity of organisms, effectively prevent and treat livestock and poultry pestilence, and promote the effect of growing of pig.
Detailed description of the invention
Transfer factor of the present invention is transfer factor powder for animals (4% content), purchased from Shijiazhuang He Cheng Bioisystech Co., Ltd.
Embodiment 1
The feed addictive with immunological enhancement of the present embodiment, comprises the raw material of following parts by weight: 10 parts of the Radixs Astragali, 10 parts of Radix Isatidis, 25 parts of the bighead atractylodes rhizomes, 10 parts of honeysuckles, 20 parts of Cordyceps sinensis polysaccharides, windproof 5 parts, 5 parts of rhizoma atractylodis, 3 parts of transfer factor.
The preparation method of the feed addictive with immunological enhancement of the present embodiment, comprises the following steps:
1) Radix Astragali, Radix Isatidis, the bighead atractylodes rhizome, honeysuckle, windproof, rhizoma atractylodis were pulverized respectively to 800 eye mesh screens;
2) take in proportion the Radix Astragali, Radix Isatidis, the bighead atractylodes rhizome, honeysuckle, windproof, the rhizoma atractylodis after sieving, mix with Cordyceps sinensis polysaccharide;
3) add again transfer factor to mix and get final product.
Embodiment 2
The feed addictive with immunological enhancement of the present embodiment, comprises the raw material of following parts by weight: 20 parts of the Radixs Astragali, 20 parts of Radix Isatidis, 10 parts of the bighead atractylodes rhizomes, 20 parts of honeysuckles, 15 parts of Cordyceps sinensis polysaccharides, windproof 8 parts, 8 parts of rhizoma atractylodis, 4 parts of transfer factor.
The preparation method of the feed addictive with immunological enhancement of the present embodiment, comprises the following steps:
1) Radix Astragali, Radix Isatidis, the bighead atractylodes rhizome, honeysuckle, windproof, rhizoma atractylodis were pulverized respectively to 700 eye mesh screens;
2) take in proportion the Radix Astragali, Radix Isatidis, the bighead atractylodes rhizome, honeysuckle, windproof, the rhizoma atractylodis after sieving, mix with Cordyceps sinensis polysaccharide;
3) add again transfer factor to mix and get final product.
Embodiment 3
The feed addictive with immunological enhancement of the present embodiment, comprises the raw material of following parts by weight: 25 parts of the Radixs Astragali, 25 parts of Radix Isatidis, 15 parts of the bighead atractylodes rhizomes, 25 parts of honeysuckles, 10 parts of Cordyceps sinensis polysaccharides, windproof 10 parts, 10 parts of rhizoma atractylodis, 5 parts of transfer factor.
The preparation method of the feed addictive with immunological enhancement of the present embodiment, comprises the following steps:
1) Radix Astragali, Radix Isatidis, the bighead atractylodes rhizome, honeysuckle, windproof, rhizoma atractylodis were pulverized respectively to 600 eye mesh screens;
2) take in proportion the Radix Astragali, Radix Isatidis, the bighead atractylodes rhizome, honeysuckle, windproof, the rhizoma atractylodis after sieving, mix with Cordyceps sinensis polysaccharide;
3) add again transfer factor to mix and get final product.
Embodiment 4
The feed addictive with immunological enhancement of the present embodiment, comprises the raw material of following parts by weight: 20 parts of the Radixs Astragali, 15 parts of Radix Isatidis, 10 parts of the bighead atractylodes rhizomes, 20 parts of honeysuckles, 15 parts of Cordyceps sinensis polysaccharides, windproof 5 parts, 5 parts of rhizoma atractylodis, 3 parts of transfer factor.
The preparation method of the feed addictive with immunological enhancement of the present embodiment, comprises the following steps:
1) Radix Astragali, Radix Isatidis, the bighead atractylodes rhizome, honeysuckle, windproof, rhizoma atractylodis were pulverized respectively to 800 eye mesh screens;
2) take in proportion the Radix Astragali, Radix Isatidis, the bighead atractylodes rhizome, honeysuckle, windproof, the rhizoma atractylodis after sieving, mix with Cordyceps sinensis polysaccharide;
3) add again transfer factor to mix and get final product.
Experimental example 1
The impact of feed addictive of the present invention on pig production performance
This experimental example normal diet used is commercially available conventional feed.
1) for examination animal: adopt single-factor 4 level designs, adopt 120 of 35 age in days Chang-Bai piglets, be divided at random 4 groups, male and female has concurrently, and pig individual weight and the state of mind selected are similar.Feeding method adopts group feeding, every day 3 times, freely drinks water.Duration of test records respectively feed intake and the swinery situation of every group of pig, and weigh and record morning every day on an empty stomach.
2) using method: establish test group and control group, control group uses commercially available normal diet, feed every day for 3 times; Test group in normal diet in mass ratio example 0.2%, 0.3%, 0.4% add the made feed addictive of the embodiment of the present invention 4, feed by control group method.
3) test period: on June 1st, 2012 was to July 30.
4) result of the test is in table 1.
The impact of table 1 feed addictive of the present invention on Production Performance of Weaning Pigs
Table 1 result shows:
1) add that the test group of mass fraction 0.2%, 0.3% and 0.4% feed addictive is heavy at end, all increasing than control group aspect daily gain and daily ingestion amount, especially taking addition as 0.4% feed addictive test group remarkable.
2) the feed addictive test group feedstuff-meat ratio that addition is 0.4% has improved 3.3%, 1.6% and 6.5% than the test group of addition 0.2%, 0.3% and control group respectively, and addition is that 0.2% and 0.3% feed addictive test group also increases than control group.
Experimental example 2
The impact of feed addictive of the present invention on pig production performance
This experimental example normal diet used is commercially available conventional feed.
1) for examination animal: adopt single-factor 4 level designs, adopt 210 of 35 age in days Chang-Bai piglets, be divided at random 7 groups, male and female has concurrently, and pig individual weight and the state of mind selected are similar.Feeding method adopts group feeding, every day 3 times, freely drinks water.Duration of test records respectively feed intake and the swinery situation of every group of pig, and weigh and record morning every day on an empty stomach.
2) using method: establish test group and control group, control group 1 uses commercially available normal diet, feed every day for 3 times; It is 0.4% 4% content transfer factor powder that control group 2 uses commercially available normal diet+mass ratio, and feed every day for 3 times; It is 0.4% Chinese medicine composition (10 parts of 25 parts of the Radixs Astragali, 10 parts of Radix Isatidis, 25 parts of the bighead atractylodes rhizomes, 25 parts of honeysuckles, 10 parts of Cordyceps sinensis polysaccharides, windproof 8 parts, rhizoma atractylodis) that control group 3 uses commercially available normal diet+mass ratio, and feed every day for 3 times; Test group is added respectively the made feed addictive of the embodiment of the present invention 1,2,3,4 in normal diet, and example is 0.4% interpolation in mass ratio, feeds by control group method.
3) test period: on June 1st, 2012 was to July 30.
4) result of the test is in table 2.
The impact of table 2 feed addictive of the present invention on Production Performance of Weaning Pigs
| ? | Just starting weight/kg | End weight/kg | Daily gain/kg | Daily ingestion amount/g | Feedstuff-meat ratio |
| Embodiment 1 | 7.43±0.76 | 29.86±2.42 | 0.37±0.05 | 884±56.32 | 2.36:1 |
| Embodiment 2 | 7.45±0.86 | 31.63±2.42 | 0.40±0.08 | 872±56.32 | 2.16:1 |
| Embodiment 3 | 7.44±0.81 | 33.89±2.85 | 0.44±0.05 | 889±58.52 | 2.05:1 |
| Embodiment 4 | 7.43±0.83 | 35.32±2.93 | 0.46±0.06 | 890±54.36 | 1.91:1 |
| Control group 1 | 7.45±0.84 | 25.52±2.65 | 0.30±0.07 | 821±53.26 | 2.73:1 |
| Control group 2 | 7.41±0.74 | 27.38±2.53 | 0.33±0.06 | 845±53.26 | 2.54:1 |
| Control group 3 | 7.44±0.53 | 28.20±2.35 | 0.35±0.04 | 858±52.65 | 2.48:1 |
Table 2 result shows:
1) test group of feed addictive of the present invention of adding mass fraction 0.4% is all being significantly improved than 1,2,3 groups of control groups aspect daily gain and feedstuff-meat ratio, especially taking addition as 0.4% embodiment 4 test group the most remarkable.
2) control group 2 is to use the 4% content transfer factor powder that commercially available normal diet+mass ratio is 0.4%, does not add Chinese medicine composition; Can be found out by result of the test, compared with embodiment 4, daily gain has declined about 0.13kg, and feedstuff-meat ratio significantly increases, and further illustrates between transfer factor and Chinese medicine composition and has cooperative effect, and the two rational proportion, can significantly improve livestock and poultry production performance.
3) to use commercially available normal diet+mass ratio be 0.4% Chinese medicine composition to control group 3, and do not add transfer factor; Can be found out by result of the test, control group 3 all has improvement to a certain degree on daily gain and feedstuff-meat ratio than control group 1, but effect is obviously not as adopting the composite embodiment 1-4 of transfer factor and Chinese medicine composition, illustrate between transfer factor and Chinese medicine composition and have cooperative effect, the two rational proportion, can significantly improve livestock and poultry production performance.
Experimental example 3
The impact of feed addictive of the present invention on pig immunologic function
This experimental example normal diet used is commercially available conventional feed.
1) for examination animal: adopt single-factor 4 level designs, adopt 210 of 35 age in days Chang-Bai piglets, be divided at random 7 groups, male and female has concurrently, and pig individual weight and the state of mind selected are similar.Feeding method adopts group feeding, every day 3 times, freely drinks water.
2) using method: establish test group and control group, control group 1 uses commercially available normal diet, feed every day for 3 times; It is 0.4% 4% content transfer factor powder that control group 2 uses commercially available normal diet+mass ratio, and feed every day for 3 times; It is 0.4% Chinese medicine composition (10 parts of 25 parts of the Radixs Astragali, 10 parts of Radix Isatidis, 25 parts of the bighead atractylodes rhizomes, 25 parts of honeysuckles, 10 parts of Cordyceps sinensis polysaccharides, windproof 8 parts, rhizoma atractylodis) that control group 3 uses commercially available normal diet+mass ratio, and feed every day for 3 times; Test group is added respectively the made feed addictive of the embodiment of the present invention 1,2,3,4 in normal diet, and example is 0.4% interpolation in mass ratio, feeds by control group method.
3) test period: on August 15th, 2012 was to October 13.
4) mensuration project: 20 piglets of random selection from every group, male and female half and half, totally 140.Gather 10ml vena cava anterior blood, get the mensuration of 2ml heparin anti-coagulating for t lymphocyte subset group (CD3, CD4, CD8) quantity, lymphocyte positive rate.The serum separating is used for measuring interleukin 2 (IL-2), gamma interferon content.Lymphocyte positive rate adopts acid α-acetic acid naphthalene lipase Determination Staining.IL-2, gamma interferon content are detected by ELISA method.IL-2, gamma interferon detection kit provide by U.S. MARKET.Adopt the U.S. EPICS-XL of Coulter company flow cytometer to detect the quantity of T lymphocyte subsets.
5) result of the test is in table 3.
The impact of table 3 feed addictive of the present invention on weanling pig immunologic function
Can find out from table 3 result of the test:
1) IL-2, gamma interferon, lymphocyte positive rate, the CD4/CD8 value of adding the test group of mass fraction 0.4% embodiment 1,2,3,4 feed addictives all increase than control group, especially taking addition as 0.4% embodiment 4 test group the most remarkable.
2) control group 2 is to use the 4% content transfer factor powder that commercially available normal diet+mass ratio is 0.4%, and does not add Chinese medicine composition; Can be found out by result of the test, compared with embodiment 4, CD4/CD8 value 0.061% left and right that declined, lymphocyte positive rate declines 1.4%, IL-2 is about the content of every milliliter of serum has declined 0.80pg, and gamma interferon is about the content of every milliliter of serum has declined 2.71pg.Further illustrate independent interpolation transfer factor and transfer factor and Chinese medicine composition the two reasonably combined compared with, improving significant difference aspect livestock and poultry body's immunity.
3) to use commercially available normal diet+mass ratio be 0.4% Chinese medicine composition to control group 3, and do not add transfer factor; Can be found out by result of the test, control group 3 is compared with control group 1, aspect IL-2, gamma interferon, lymphocyte positive rate, CD4/CD8 value, all there iing improvement to a certain degree, but effect is obviously not as adopting transfer factor and the composite embodiment 1-4 of Chinese medicine composition, illustrates that the present invention adopts transfer factor and Chinese medicine composition is composite and there is significant effect.
Claims (5)
1. one kind has the feed addictive of immunological enhancement, it is characterized in that, described feed addictive comprises the raw material of following parts by weight: 10～25 parts of the Radixs Astragali, 10～25 parts of Radix Isatidis, 10～25 parts of the bighead atractylodes rhizomes, 10～25 parts of honeysuckles, 10～20 parts of Cordyceps sinensis polysaccharides, windproof 5～10 parts, 5～10 parts of rhizoma atractylodis, 3～5 parts of transfer factor.
2. a kind of feed addictive with immunological enhancement according to claim 1, it is characterized in that, described feed addictive comprises the raw material of following parts by weight: 20 parts of the Radixs Astragali, 15 parts of Radix Isatidis, 10 parts of the bighead atractylodes rhizomes, 20 parts of honeysuckles, 15 parts of Cordyceps sinensis polysaccharides, windproof 5 parts, 5 parts of rhizoma atractylodis, 3 parts of transfer factor.
3. a preparation method for the feed addictive with immunological enhancement as claimed in claim 1, is characterized in that, comprises the following steps:
1) Radix Astragali, Radix Isatidis, the bighead atractylodes rhizome, honeysuckle, windproof, rhizoma atractylodis are pulverized and sieved respectively to net;
2) take in proportion the Radix Astragali, Radix Isatidis, the bighead atractylodes rhizome, honeysuckle, windproof, the rhizoma atractylodis after sieving, mix with Cordyceps sinensis polysaccharide;
3) add again transfer factor to mix and get final product.
4. the preparation method of a kind of feed addictive with immunological enhancement according to claim 3, is characterized in that, described screen cloth is 600-800 order.
5. a feed addictive as claimed in claim 1 has the application in the feed of immunological enhancement in preparation.
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