CN114209769A

CN114209769A - Natural plant composition for improving animal immunity and application thereof

Info

Publication number: CN114209769A
Application number: CN202111652885.XA
Authority: CN
Inventors: 吴小萍; 陈占省; 郝强; 闫素素; 申艳敏; 李跃如; 杨文涛; 徐天天; 陈冠珠
Original assignee: Henan Jindazhong Bioengineering Co ltd
Current assignee: Henan Jindazhong Bioengineering Co ltd
Priority date: 2021-12-30
Filing date: 2021-12-30
Publication date: 2022-03-22
Anticipated expiration: 2041-12-30
Also published as: CN114209769B

Abstract

The invention provides a natural plant composition for improving animal immunity and application thereof, and relates to the technical field of animal feed additives. The natural plant composition is added to the traditional Chinese medicine formula Sijunzi decoction, and astragalus mongholicus, pollen typhae, semen allii tuberosi, fructus rosae laevigatae and wild buckwheat rhizome are added; the natural plant feed composition has the effects of tonifying qi and spleen, invigorating qi and yang, strengthening body resistance and eliminating evil, and detoxifying and astringing, and can accelerate metabolism of various toxins and harmful substances in an organism and quickly improve the immunity and health level of the organism.

Description

Natural plant composition for improving animal immunity and application thereof

Technical Field

The invention relates to the technical field of animal feed additives, in particular to a natural plant composition for improving animal immunity and application thereof.

Background

The traditional Chinese medicine is taken as a peculiar precious resource in China, is prepared from natural plants, animals or mineral substances, and leaves a deep branding in the development of Chinese civilization after hundreds of years of clinical demonstration under the guidance of the traditional Chinese medicine theory. The natural plant for feeding has the advantages of nature and no residue, and also has double functions of medicine and nutrition. The traditional Chinese medicine formula, the classic and famous formula, Sijunzi decoction, is composed of ginseng, bighead atractylodes rhizome, poria cocos and liquorice, has the effects of tonifying qi, tonifying qi and invigorating spleen, and is mainly used for treating spleen and stomach qi deficiency syndrome, poor appetite and emaciation. Deficiency of spleen-stomach qi is caused by transportation, transformation and hypodynamia; the spleen and stomach are the acquired origin, the source of qi and blood generation, and the spleen and stomach are qi-deficient, so that the appetite is reduced; qi deficiency of the spleen and stomach, endogenous dampness, dysfunction of the spleen and stomach in transportation and transformation, insufficient blood and blood generation, emaciation and hypoimmunity. In the four-monarch-seed decoction formula, ginseng is the monarch, is sweet and warm, and has the effects of tonifying qi, strengthening spleen and nourishing stomach; the bitter and warm white atractylodes rhizome is taken as the ministerial drug, so that the spleen is strengthened, the dampness is eliminated, and the qi benefiting and transportation assisting force is enhanced; when the tuckahoe and rhizoma atractylodis are matched, the effect of tonifying spleen and eliminating dampness is good; to make radix Glycyrrhizae Preparata mix with other herbs, tonify qi and regulate the middle warmer, and harmonize the effects of all the herbs. The four medicines are combined to play the role of replenishing qi to invigorate the spleen.

With the scale of the breeding industry, the farm gradually has the characteristics of high breeding density and poor breeding environment. The breeding density is high, the animal stress is caused, the physiological and biochemical indexes related to the immune function and the energy metabolism are abnormal, the phenomena of low immunity, reduced metabolic level, reduced reproductive function and the like of the bred animals are caused, and the production performance of the animals is seriously lower than the due level. Meanwhile, due to high breeding density, a plurality of breeding animals are limited in a tiny space without movement space, the metabolic capability of the animals is seriously reduced, a large amount of toxins and harmful substances in the organism are accumulated, and the health condition of the animals is further worsened. The reduction of the immunity of the animal organism can also cause the large-scale outbreak of animal epidemic diseases, and the production benefit of the cultured animals is seriously reduced.

Based on the background, the invention adds or subtracts traditional Chinese medicine prescription of Sijunzi decoction, and adds astragalus root, cattail pollen, Chinese chive seed, cherokee rose fruit and wild buckwheat rhizome; provides a natural plant feed composition which has the effects of tonifying qi and spleen, invigorating qi and yang, strengthening body resistance and eliminating evil, detoxifying and astringing, can accelerate the metabolism of various toxins and harmful substances in an organism and can quickly improve the immunity and health level of the organism.

Disclosure of Invention

Technical problem to be solved

Aiming at the defects of the prior art, the invention provides a natural plant composition for improving the immunity of animals and application thereof, wherein the composition has the effects of tonifying qi and spleen, tonifying qi and invigorating yang, strengthening body resistance and eliminating evil, and detoxifying and astringing, and can accelerate the metabolism of various toxins and harmful substances in an organism and quickly improve the immunity and health level of the organism.

(II) technical scheme

In order to achieve the purpose, the invention is realized by the following technical scheme:

on one hand, the invention provides a natural plant composition for improving animal immunity, which consists of astragalus, ginseng, bighead atractylodes rhizome, poria cocos, cattail pollen, leek seeds, cherokee rose fruit, wild buckwheat rhizome and liquorice.

Further, the composition consists of the following raw materials in parts by weight: 35-50 parts of astragalus membranaceus, 28-45 parts of ginseng, 28-45 parts of bighead atractylodes rhizome, 28-45 parts of poria cocos, 30-55 parts of pollen typhae, 15-30 parts of Chinese chive seeds, 10-25 parts of cherokee rose fruits, 10-25 parts of wild buckwheat rhizome and 20-35 parts of liquorice.

Further, the composition consists of the following raw materials in parts by weight: 40-50 parts of astragalus membranaceus, 35-45 parts of ginseng, 35-45 parts of bighead atractylodes rhizome, 35-45 parts of poria cocos, 30-40 parts of pollen typhae, 20-30 parts of Chinese chive seeds, 15-25 parts of cherokee rose fruits, 10-20 parts of wild buckwheat rhizome and 20-30 parts of liquorice.

Further, the composition consists of the following raw materials in parts by weight: 50 parts of astragalus membranaceus, 40 parts of ginseng, 40 parts of bighead atractylodes rhizome, 40 parts of poria cocos, 30 parts of pollen typhae, 25 parts of Chinese chive seeds, 25 parts of cherokee rose fruits, 10 parts of wild buckwheat rhizome and 20 parts of liquorice.

Further, the composition can be prepared into powder, oral liquid, granules, mixed feed and fermented mixed feed according to the clinical application requirements of animal breeding.

Further, the composition is used for preparing a feed additive for animals.

The natural plant composition of the invention has the following pharmacological actions of the traditional Chinese medicine components:

astragalus root: sweet in taste, slightly warm in nature, and entering spleen and lung meridians; has the effects of invigorating qi, consolidating superficial resistance, expelling toxin, expelling pus, promoting urination, and promoting granulation; can be used for treating deficiency of vital energy, asthenia, chronic diarrhea, proctoptosis, spontaneous perspiration, edema, uterine prolapse, albuminuria due to chronic nephritis, diabetes, and unhealed wound; radix astragali contains effective components such as saccharide, amino acids, protein, choline, betaine, folic acid, vitamin P, amylase, and trace elements, and has effects of enhancing immunity and resisting virus.

Ginseng: sweet, bitter and neutral in flavor, and enter spleen, lung and heart meridians; has effects in invigorating primordial qi, restoring pulse, relieving depletion, invigorating spleen, benefiting lung, promoting salivation, nourishing blood, tranquilizing mind, and improving intelligence; is mainly used for treating diseases such as asthenia, anorexia, spleen deficiency, loose stool, short breath, hypodynamia, heart failure and the like; modern researches find that ginseng has the pharmacological effects of resisting fatigue, protecting cardiovascular and hepatic systems, resisting stress, resisting mutagenesis, resisting oxidation, resisting diabetes, resisting inflammation, resisting cancer and the like.

White atractylodes rhizome: bitter and sweet in taste, warm in nature, entering spleen and stomach meridians; has the effects of strengthening spleen, replenishing qi, eliminating dampness, promoting diuresis, arresting sweating, preventing miscarriage, etc.; it is often used for spleen deficiency, poor appetite, diarrhea, loose stool, threatened abortion, etc.; the main chemical components of the composition comprise volatile oil, polysaccharide, lactone and the like, and the composition has the effects of resisting tumors, resisting inflammation, regulating digestive systems and the like.

Tuckahoe, poria cocos: sweet and light taste, neutral in nature, and entering heart, lung, spleen and kidney meridians; is beneficial to the water and dampness permeability. Invigorating spleen and calming heart; can be used for treating edema, oliguria, spleen deficiency, anorexia, loose stool, diarrhea, uneasiness, palpitation, and insomnia; the main chemical components of tuckahoe are pachyman and triterpenes, and modern pharmacological research shows that tuckahoe has the functions of diuresis, anti-inflammation, bacteriostasis, liver protection, immunity enhancement and the like.

Cattail pollen: sweet in taste and mild in nature; has effects in stopping bleeding, dispelling blood stasis, and treating stranguria; can be used for treating hematemesis, hemoptysis, metrorrhagia, traumatic hemorrhage, and stranguria with blood and damp pain; pollen Typhae mainly contains effective chemical components such as flavonoids, sterols, amino acids, volatile oils, and organic acids; modern pharmacological research shows that the cattail pollen has the effects of easing pain, resisting coagulation, promoting blood circulation, reducing blood fat, preventing and treating arteriosclerosis, resisting inflammation, enhancing immunity and the like.

Leek seeds: pungent in flavor and warm in nature, entering kidney and liver meridians; has effects in warming and invigorating liver and kidney, supporting yang, and stopping nocturnal emission; can be used for treating spermatorrhea, soreness of waist and knees, enuresis, frequent micturition, leukorrhagia, etc.; the leek seeds mainly contain alkaloids, nucleosides, steroid saponins, volatile oils, unsaturated fatty acids and other effective components, and modern pharmacological research shows that the leek seeds have the effects of tonifying kidney and strengthening yang, nourishing liver, securing essence and the like, and are mainly clinically applicable to symptoms such as impotence, cold pain of waist and knees caused by liver-yang deficiency and kidney-yang deficiency, spermatorrhea, enuresis, frequent micturition, leukorrhagia and the like caused by insecurity of kidney deficiency.

Cherokee rose fruit: sour, sweet, astringent and neutral in nature; entering kidney, bladder and large intestine meridians; has the effects of securing essence and reducing urination, securing metrorrhagia and stopping leukorrhagia, astringing intestines and checking diarrhea and the like; can be used for treating spermatorrhea, enuresis, frequent micturition, metrorrhagia, leukorrhagia, chronic diarrhea, and dysentery; the cherokee rose fruit mainly contains effective chemical components such as polysaccharide, triterpene, tannin, flavonoid and the like; modern pharmacological research shows that the cherokee rose fruit has the effects of resisting oxidation, regulating immunity, reducing blood sugar and blood fat, inhibiting bacteria, diminishing inflammation, resisting tumors and the like, and simultaneously has good antipyretic, antidiarrheal, analgesic and hemostatic effects.

Wild buckwheat rhizome: pungent and astringent taste, cool in nature, entering lung meridian; has effects in clearing away heat and toxic materials, expelling pus, and dispelling blood stasis, and can be used for treating lung heat cough and asthma, laryngopharynx pain, dyspepsia, hepatitis abdominal distention, and rheumatalgia; the active ingredients in rhizoma Fagopyri Dibotryis mainly proanthocyanidin glycoside condensed tannin mixture, and also contains effective ingredients such as tannin, flavone, glycoside, steroid, terpene, volatile oil, organic acid, etc.; modern pharmacological studies show that the wild buckwheat rhizome has the effects of resisting tumors, diminishing inflammation, resisting bacteria, regulating immunity and the like.

Licorice root: sweet taste, neutral nature, and enter heart, spleen, lung and stomach meridians; has the effects of invigorating spleen and replenishing qi, clearing away heat and toxic materials, eliminating phlegm and relieving cough, relieving spasm and pain, and harmonizing the medicines; it can be used for treating weakness of spleen and stomach, asthenia, palpitation, short breath, cough, excessive phlegm, carbuncle, swelling, and sore, and radix Glycyrrhizae is good at harmonizing drug properties and relieving toxicity of drugs.

(III) advantageous effects

The invention provides a natural plant composition for improving animal immunity and application thereof. The natural plant composition is added to the traditional Chinese medicine formula Sijunzi decoction, and astragalus mongholicus, pollen typhae, semen allii tuberosi, fructus rosae laevigatae and wild buckwheat rhizome are added; the natural plant feed composition has the effects of tonifying qi and spleen, invigorating qi and yang, strengthening body resistance and eliminating evil, and detoxifying and astringing, and can accelerate metabolism of various toxins and harmful substances in an organism and quickly improve the immunity and health level of the organism. Animal experiments can fully show that compared with the traditional four-monarch-seed powder formula, the formula disclosed by the invention can improve the oxygen carrying capacity of red blood cells, improve the health level of animal organisms, reduce the stress reaction of the animal organisms to the outside, improve the immunity of the organisms and enhance the adaptability of the organisms to the outside environment.

Detailed Description

In order to make the objects, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the embodiments of the present invention, and it is obvious that the described embodiments are some embodiments of the present invention, but not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

Example 1

A natural plant composition for improving animal immunity is composed of the following raw materials in parts by weight: 35 parts of astragalus membranaceus, 28 parts of ginseng, 28 parts of bighead atractylodes rhizome, 28 parts of poria cocos, 30 parts of pollen typhae, 15 parts of Chinese chive seeds, 10 parts of cherokee rose fruits, 10 parts of wild buckwheat rhizome and 20 parts of liquorice.

The composition can be prepared into powder, oral liquid, granules, mixed feed or fermented mixed feed according to the clinical application requirements of animal breeding, and various prepared formulations can be used as feed additives to be added into the daily feed of bred animals.

Example 2

This example differs from example 1 in that:

the composition is prepared from the following raw materials in parts by weight: 50 parts of astragalus membranaceus, 45 parts of ginseng, 45 parts of bighead atractylodes rhizome, 45 parts of poria cocos, 55 parts of pollen typhae, 30 parts of Chinese chive seeds, 25 parts of cherokee rose fruits, 25 parts of wild buckwheat rhizome and 35 parts of liquorice.

Example 3

This example differs from example 1 in that:

the composition is prepared from the following raw materials in parts by weight: 40 parts of astragalus membranaceus, 35 parts of ginseng, 35 parts of bighead atractylodes rhizome, 35 parts of poria cocos, 30 parts of pollen typhae, 20 parts of Chinese chive seeds, 15 parts of cherokee rose fruits, 10 parts of wild buckwheat rhizome and 20 parts of liquorice.

Example 4

This example differs from example 1 in that:

the composition is prepared from the following raw materials in parts by weight: 50 parts of astragalus membranaceus, 45 parts of ginseng, 45 parts of bighead atractylodes rhizome, 45 parts of poria cocos, 40 parts of pollen typhae, 30 parts of Chinese chive seeds, 25 parts of cherokee rose fruits, 20 parts of wild buckwheat rhizome and 30 parts of liquorice.

Example 5

This example differs from example 1 in that:

the composition is prepared from the following raw materials in parts by weight: 50 parts of astragalus membranaceus, 40 parts of ginseng, 40 parts of bighead atractylodes rhizome, 40 parts of poria cocos, 30 parts of pollen typhae, 25 parts of Chinese chive seeds, 25 parts of cherokee rose fruits, 10 parts of wild buckwheat rhizome and 20 parts of liquorice.

Comparative example 1

This example differs from example 5 in that:

the composition is prepared from the following raw materials in parts by weight: 40 parts of ginseng, 40 parts of bighead atractylodes rhizome, 40 parts of poria cocos and 20 parts of liquorice.

Test example 1

In order to further prove the influence of the formula of the invention on improving the immunity of the cultured animals, the following animal experiments are provided for explanation.

Test animals and groups

Selecting 60 ternary sows (Duroc, Dabai and Changbai) with consistent gestation times and similar weight, randomly dividing the 60 sows into three groups which are respectively a blank group, a test group and a control group by adopting a single-factor influence design test; wherein the blank group of drinking water and feed maintains the original standard unchanged; test group 1000g of the powder prepared according to the formulation of example 5 was added to each 100kg of feed; in the control group, 1000g of Sijunzi powder is added into every 100kg of feed, namely the powder prepared by the formula in the comparative example 1; the preparation method of the powder comprises the following steps: cleaning and drying the raw materials, weighing the raw materials according to the weight parts of each formula, crushing, sieving by a 80-mesh sieve, and uniformly mixing to obtain the powder. Each group of test pigs eat and drink water freely, the breeding standards are kept consistent, and the immune disinfection procedure is carried out according to the conventional method of a pig farm; the test is carried out by pre-feeding for 7 days before the test, and the formal test time is 30 days.

2 blood sample Collection and detection

Ear vein blood collection was performed on each test pig group on day 0, 14 and 28 of the main test period, and the blood was divided into two portions, one portion was anticoagulated with EDTA at a final concentration of 1.5mg/mL, and the other portion was not anticoagulated. Wherein the anticoagulant is added into the sample, and the blood component indexes including the content of Red Blood Cells (RBC), Hemoglobin (HGB) and average red blood cell hemoglobin (MCH) are measured by a red blood cell analyzer; blood without anticoagulant was centrifuged and plasma was collected and the plasma was assayed for cortisol and IgG content using a cortisol and immunoglobulin G (IgG) kit.

3 data analysis and processing

Data analysis statistical tests were performed on all data using SAS9.0 software and results are expressed as mean ± standard deviation and as (P <0.05) for significant differences.

3. Test result and evaluation of biochemical indexes of test pig blood

Table 1 shows the results of the powder prepared by the formula of the invention and the Sijunzi powder on the biochemical indexes of the blood of the test pigs. From the results in Table 1, it can be seen that the hemoglobin content of the blank group was increased by 0% and 2.8% on days 14 and 28 of the test, respectively, as compared with the case of day 0; the hemoglobin content of the test group is respectively improved by 18.3 percent and 19.2 percent; the hemoglobin content of the control group is respectively improved by 7.5 percent and 9.3 percent; compared with the blank group, the test group and the control group have the contents of red blood cells, hemoglobin and average hemoglobin which are obviously higher than those of the blank group, and have obvious difference (P <0.05), which shows that the oxygen carrying capacity of the red blood cells can be improved by adding the natural plant composition as a feed additive, and the contents of the red blood cells, the hemoglobin and the average hemoglobin of the test group are also obviously higher than those of the control group, so that the formula powder can enhance the oxygen carrying capacity of the red blood cells and obviously improve the health level of test animals compared with Sijunzi powder.

The results in table 1 show that the content of IgG in the test group and the control group is gradually reduced along with the increase of the feeding time, and the reduction range of the content of IgG in the test group is more obvious than that in the control group, and has a significant difference (P <0.05), which indicates that the powder of the invention can reduce the stress response of the body to the outside compared with Sijunzi san.

As can be seen from the results in table 1, the cortisol content of the vermilion blank was reduced by 1.2% and 2.1% on days 14 and 28 of the test, respectively, as compared with the case of day 0; the cortisol content of the test group is reduced by 8.5 percent and 25.7 percent respectively; the cortisol content of the control group was reduced by 6.2% and 4.2%, respectively; compared with the blank group, the cortisol content of the test group and the control group is obviously lower than that of the blank group, the difference is obvious (P is less than 0.05), the fact that the stress response of the animal can be reduced by adding the natural plant composition as the feed additive is proved, the cortisol content of the test group is obviously lower than that of the control group, and the fact that the powder prepared by the formula of the invention can reduce the stress response of the test animal and enhance the adaptability of the test animal to the external environment compared with the Sijunzi san is proved.

TABLE 1 determination of biochemical indicators of blood of test pigs by the formula product of the invention

Note: different letters in the same column of data indicate significant differences (p < 0.05).

The test results fully show that compared with the traditional four-monarch-seed powder formula, the formula disclosed by the invention can improve the oxygen carrying capacity of red blood cells, improve the health level of animal organisms, reduce the stress reaction of the animal organisms to the outside, improve the immunity of the organisms and enhance the adaptability of the organisms to the outside environment.

The above examples are only intended to illustrate the technical solution of the present invention, but not to limit it; although the present invention has been described in detail with reference to the foregoing embodiments, it will be understood by those of ordinary skill in the art that: the technical solutions described in the foregoing embodiments may still be modified, or some technical features may be equivalently replaced; and such modifications or substitutions do not depart from the spirit and scope of the corresponding technical solutions of the embodiments of the present invention.

Claims

1. A natural plant composition for improving animal immunity is characterized by comprising astragalus, ginseng, bighead atractylodes rhizome, poria cocos, pollen typhae, leek seeds, cherokee rose fruits, wild buckwheat rhizome and liquorice.

2. The natural plant composition for improving animal immunity according to claim 1, wherein the composition is prepared from the following raw materials in parts by weight: 35-50 parts of astragalus membranaceus, 28-45 parts of ginseng, 28-45 parts of bighead atractylodes rhizome, 28-45 parts of poria cocos, 30-55 parts of pollen typhae, 15-30 parts of Chinese chive seeds, 10-25 parts of cherokee rose fruits, 10-25 parts of wild buckwheat rhizome and 20-35 parts of liquorice.

3. The natural plant composition for improving animal immunity according to claim 1, wherein the composition is prepared from the following raw materials in parts by weight: 40-50 parts of astragalus membranaceus, 35-45 parts of ginseng, 35-45 parts of bighead atractylodes rhizome, 35-45 parts of poria cocos, 30-40 parts of pollen typhae, 20-30 parts of Chinese chive seeds, 15-25 parts of cherokee rose fruits, 10-20 parts of wild buckwheat rhizome and 20-30 parts of liquorice.

4. The natural plant composition for improving animal immunity according to claim 1, wherein the composition is prepared from the following raw materials in parts by weight: 50 parts of astragalus membranaceus, 40 parts of ginseng, 40 parts of bighead atractylodes rhizome, 40 parts of poria cocos, 30 parts of pollen typhae, 25 parts of Chinese chive seeds, 25 parts of cherokee rose fruits, 10 parts of wild buckwheat rhizome and 20 parts of liquorice.

5. The natural plant composition for improving animal immunity according to claim 1, wherein the composition is prepared into any one of powder, oral liquid, granules, mixed feed or fermented mixed feed according to the clinical application requirements of animal breeding.

6. The natural plant composition for improving animal immunity according to claim 5, wherein the composition is used for preparing animal feed additive.