CN102688471A - Compound preparation for preventing fatigue - Google Patents
Compound preparation for preventing fatigue Download PDFInfo
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- CN102688471A CN102688471A CN201210198977XA CN201210198977A CN102688471A CN 102688471 A CN102688471 A CN 102688471A CN 201210198977X A CN201210198977X A CN 201210198977XA CN 201210198977 A CN201210198977 A CN 201210198977A CN 102688471 A CN102688471 A CN 102688471A
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Abstract
The invention provides a compound preparation for preventing fatigue, which mainly comprises ginseng, white peony root, dried ginger, cassia bark, dried tangerine peel, Chinese date, Chinese angelica, liquorice, taurine and the like. The compound preparation has scientific compatibility, small toxic and toxic effect, good taste and easy absorption by human bodies, so that the fatigue symptom can be remarkably improved, and the body immunity can be increased.
Description
Technical field:
The present invention provides a kind of compound preparation with antifatigue effect, belongs to the medical health product technical field.
Background technology:
Along with the development of society, the enhancing of high efficiency work, allegro life, competitive spirit, people's muscle power, mentality are in tension for a long time, directly cause chronic fatigue syndrome to take place, and the patient who is chief complaint with fatigue is clinically increased day by day.Fatigue is meant body under the certain environment condition, the temporarily-depressed a kind of Physiological Psychology phenomenon of work efficiency that causes owing to long-time or too heavy, nervous work (comprising mentality and muscle power).Modern medicine thinks that the tired reason that produces is many-sided, and energy exhaustion is one of major reason.And the tired elimination in motion back is an important difficult problem that faces clinically.The effect of anti-fatigue medicament is exactly to want the generation of delay fatigue and the elimination that accelerates fatigue.For a long time; Seek safety, effectively, the medicine that has no side effect comes the generation of delay fatigue and the elimination that accelerates fatigue is one of focus of drug research always; Motherland's traditional medicine is because of characteristics such as its medicine-food two-purpose, adaptation population be extensive; The crowd who is very suitable for fatigue syndrome selects, and is boundless in the application prospect in this field.
Summary of the invention:
The invention provides a kind of compound preparation, have that flavour of a drug are less, definite ingredients, nontoxic characteristics and the anti-fatigue health-caring function is arranged with antifatigue effect.
The present invention is the compound preparation with antifatigue effect, by following raw materials by weight portion than processing:
50 ~ 70 parts of Radix Ginsengs, 5 ~ 20 parts of the Radix Paeoniae Albas, 65 ~ 80 parts of Rhizoma Zingiberiss, 10 ~ 25 parts on Cortex cinnamomi japonici (Ramulus Cinnamomi), 5 ~ 20 parts of Pericarpium Citri Reticulataes, 25 ~ 40 parts in Fructus Jujubae, 3 ~ 20 parts of Radix Angelicae Sinensis, 10 ~ 25 parts in Radix Glycyrrhizae, taurine 0.2 ~ 1g/50mL preparation.
Optimum ratio of the present invention is:
60 parts of Radix Ginsengs, 12 parts of the Radix Paeoniae Albas, 70 parts of Rhizoma Zingiberiss, 15 parts on Cortex cinnamomi japonici (Ramulus Cinnamomi), 10 parts of Pericarpium Citri Reticulataes, 30 parts in Fructus Jujubae, 6 parts of Radix Angelicae Sinensis, 12 parts in Radix Glycyrrhizae, taurine 0.5g/50mL preparation.
The present invention has the preparation technology of the functional food of antifatigue effect, may further comprise the steps:
1) take by weighing Radix Ginseng, the Radix Paeoniae Alba, Rhizoma Zingiberis, Cortex cinnamomi japonici (Ramulus Cinnamomi), Pericarpium Citri Reticulatae in proportion, add 60% alcohol reflux 2 ~ 3 hours of 6 ~ 8 times of weight, extract altogether 2 times,, merge the alcohol extract that extracts for 2 times with sieve elimination medicinal residues,, subsequent use in the water-bath Back stroke to there not being the alcohol flavor;
2) take by weighing Fructus Jujubae, Radix Angelicae Sinensis, Radix Glycyrrhizae in proportion, the water logging that adds 6 ~ 8 times of weight was steeped 2 ~ 3 hours, carried out reflux, extract, 2 ~ 3 hours, extracted altogether 3 times, with sieve elimination medicinal residues, merged the water extract of 3 extractions, and is subsequent use;
3) medicinal liquid of combining step 1 and step 2 is concentrated into 1/4 of cumulative volume, sucking filtration, and filtrating adds dehydrated alcohol to 50% determining alcohol to remove impurity, and room temperature leaves standstill 48h;
4) medicinal liquid with step 3 carries out sucking filtration, and filtrating places the water-bath Back stroke not distinguish the flavor of to there being alcohol, sucking filtration, and filtrating adds dehydrated alcohol to 75% determining alcohol to remove impurity, cold preservation 48h;
5) medicinal liquid behind step 4 precipitate with ethanol is carried out sucking filtration, filtrating places the water-bath Back stroke not distinguish the flavor of to there being alcohol, sucking filtration, and filtrating adds 2.5 times water, boils 10min, is cooled to room temperature, cold preservation 48h;
6) medicinal liquid that extracts the step 5 contain crude drug amount 2.15 grams is diluted to 50mL, adds 500mg taurine, 5mg vitamin B then
2, the 20mg vitamin B
3, the 5mg vitamin B
6, add 5mg sucrose, 0.5mL glycerol, 20mg potassium sorbate, 150mg polyvinylpyrrolidone, 1g polyoxyethylene hydrogenated Oleum Ricini, transfer pH to 3～4 to process preparation of the present invention with citric acid.
Usage and dosage:1 time/day; 50mL/ time.
Indication:Can eliminate the muscular soreness and the feeling of fatigue that cause owing to motion fast, the discharge of acceleration bodies intracellular metabolite material, and ability health invigorating, building body.
Prescription analysis:Utilize among the present invention
Radix GinsengBe the principal agent of big tonifying the spleen and stomach vigour, strengthening the body resistance, in conjunction with
The Radix Paeoniae AlbaRegulate immune effect and strengthen anoxia enduring and antioxidation, anti-fatigue ability,
Radix Angelicae SinensisAlso have effects such as anti-hypoxia, antitumor, radioprotective, antalgic and inflammation relieving, can improve and control blood system, and can regulate body's immunity, enhancing human body immunity power.
Fructus JujubaeIn jujube polysaccharide effectively remove intravital oxygen-derived free radicals, promote the macrophage TNF secretion, strengthen immune function of mice, non-activated mouse boosting cell is had the promotion proliferation function.
Rhizoma Zingiberis, Cortex cinnamomi japonici (Ramulus Cinnamomi)Have dispersing cold for relieving pain, warming the meridian and promoting blood circulation is mended the supporing yang effect of fire, can blood vessel dilating, and blood circulation promoting strengthens the antifatigue effect of above-mentioned Chinese medicine.
Pericarpium Citri ReticulataeRegulating qi-flowing for strengthening spleen, in the accent, dampness is reduced phlegm, and
Radix GlycyrrhizaeBut enhancing human body immunity power can suppress gastric secretion, promote ulcer healing, and the gastrointestinal smooth muscle spasmolysis is arranged, but also antitumor and relieving cough and expelling phlegm can be in harmonious proportion the Xin Wen of said medicine, the property of drying, the effect of enhancing tonification.All medicines are compatibility each other, synergism, and
TaurineCan promote pituitary hormone secretion, the activation pancreatic function improves the organism endocrine system mode, and can promote immunity of organisms and resisting fatigue, brings into play the effect of resisting fatigue jointly with Chinese medicine ingredients.
Good effect of the present invention is:Compound preparation, the science compatibility, toxic and side effects is little, and mouthfeel is all good, is easily absorbed by the body, and significantly improves fatigue symptom, human body immunity improving power.
Practical implementation is following:
Embodiment 1
1) take by weighing Radix Ginseng 60g, Radix Paeoniae Alba 12g, Rhizoma Zingiberis 70g, Cortex cinnamomi japonici (Ramulus Cinnamomi) 15g, Pericarpium Citri Reticulatae 10g mixes, and adds 6 times of weight, 60% alcohol reflux 3 hours, extracts altogether 2 times, with sieve elimination medicinal residues, merges the alcohol extract of 2 extractions, and is to there not being the alcohol flavor, subsequent use in the water-bath Back stroke;
2) take by weighing Fructus Jujubae 30g, Radix Angelicae Sinensis 6g, Radix Glycyrrhizae 12g mixes, and adds 7 times of weight water logging bubbles 3 hours, and reflux, extract, 2 hours is extracted 3 times altogether, with sieve elimination medicinal residues, merges the water extract of 3 extractions, and is subsequent use;
3) combining step 1) with step 2) medicinal liquid, be concentrated into 1/4 of cumulative volume, sucking filtration, filtrating adds dehydrated alcohol to 50% determining alcohol to remove impurity, room temperature leaves standstill 48h;
4) medicinal liquid with step 3) carries out sucking filtration, and filtrating places the water-bath Back stroke not distinguish the flavor of to there being alcohol, sucking filtration, and filtrating adds dehydrated alcohol to 75% determining alcohol to remove impurity, cold preservation 48h;
5) medicinal liquid behind the step 4) precipitate with ethanol is carried out sucking filtration, filtrating places the water-bath Back stroke not distinguish the flavor of to there being alcohol, sucking filtration, and filtrating adds 2.5 times water, boils 10min, is cooled to room temperature, cold preservation 48h;
6) medicinal liquid that extracts the step 5) contain crude drug amount 2.15 grams is diluted to 50mL, adds 500mg taurine, vitamin B then
25mg, vitamin B
320mg, vitamin B
65mg, adding sucrose 5mg, glycerol 0.5mL, potassium sorbate 20mg, polyvinylpyrrolidone 150mg, polyoxyethylene hydrogenated Oleum Ricini 1g, citric acid transfer pH to 3.8 to process preparation of the present invention.
Embodiment 2
1) take by weighing Radix Ginseng 55g, Radix Paeoniae Alba 10g, Rhizoma Zingiberis 65g, Cortex cinnamomi japonici (Ramulus Cinnamomi) 10g, Pericarpium Citri Reticulatae 15g mixes, and adds 7 times of weight, 60% alcohol reflux 3 hours, extracts altogether 2 times, with sieve elimination medicinal residues, merges the alcohol extract of 2 extractions, and is to there not being the alcohol flavor, subsequent use in the water-bath Back stroke;
2) take by weighing Fructus Jujubae 25g, Radix Angelicae Sinensis 10g, Radix Glycyrrhizae 10g mixes, and adds 6 times of weight water logging bubbles 3 hours, and reflux, extract, 2 hours is extracted 3 times altogether, with sieve elimination medicinal residues, merges the water extract of 3 extractions, and is subsequent use;
3) ~ 6) with embodiment 1 step 3) ~ 6).
Embodiment 3
1) take by weighing Radix Ginseng 70g, Radix Paeoniae Alba 15g, Rhizoma Zingiberis 75g, Cortex cinnamomi japonici (Ramulus Cinnamomi) 16g, Pericarpium Citri Reticulatae 12g mixes, and adds 8 times of weight, 60% alcohol reflux 3 hours, extracts altogether 2 times, with sieve elimination medicinal residues, merges the alcohol extract of 2 extractions, and is to there not being the alcohol flavor, subsequent use in the water-bath Back stroke;
2) take by weighing Fructus Jujubae 27g, Radix Angelicae Sinensis 5g, Radix Glycyrrhizae 10g mixes, and adds 8 times of weight water logging bubbles 3 hours, and reflux, extract, 2 hours is extracted 3 times altogether, with sieve elimination medicinal residues, merges the water extract of 3 extractions, and is subsequent use;
3) ~ 6) with embodiment 1 step 3) ~ 6).
Embodiment 4
1) take by weighing Radix Ginseng 70g, Radix Paeoniae Alba 20g, Rhizoma Zingiberis 70g, Cortex cinnamomi japonici (Ramulus Cinnamomi) 10g, Pericarpium Citri Reticulatae 14g mixes, and adds 6 times of weight, 60% alcohol reflux 3 hours, extracts altogether 2 times, with sieve elimination medicinal residues, merges the alcohol extract of 2 extractions, and is to there not being the alcohol flavor, subsequent use in the water-bath Back stroke;
2) take by weighing Fructus Jujubae 40g, Radix Angelicae Sinensis 7g, Radix Glycyrrhizae 24g mixes, and adds 7 times of weight water logging bubbles 3 hours, and reflux, extract, 2 hours is extracted 3 times altogether, with sieve elimination medicinal residues, merges the water extract of 3 extractions, and is subsequent use;
3) ~ 6) with embodiment 1 step 3) ~ 6).
Embodiment 5
1) take by weighing Radix Ginseng 66g, Radix Paeoniae Alba 17g, Rhizoma Zingiberis 75g, Cortex cinnamomi japonici (Ramulus Cinnamomi) 12g, Pericarpium Citri Reticulatae 9g mixes, and adds 7 times of weight, 60% alcohol reflux 3 hours, extracts altogether 2 times, with sieve elimination medicinal residues, merges the alcohol extract of 2 extractions, and is to there not being the alcohol flavor, subsequent use in the water-bath Back stroke;
2) take by weighing Fructus Jujubae 27g, Radix Angelicae Sinensis 10g, Radix Glycyrrhizae 25g mixes, and adds 7 times of weight water logging bubbles 3 hours, and reflux, extract, 2 hours is extracted 3 times altogether, with sieve elimination medicinal residues, merges the water extract of 3 extractions, and is subsequent use;
3) ~ 6) with embodiment 1 step 3) ~ 6).
Following pharmacological evaluation proves therapeutic effect of the present invention:
Through testing the beneficial effect of further elaboration functional food according to the invention, measure to confirm the resisting fatigue effect of functional food through swimming time, serum index, hepatic glycogen.
1, experimental drug: positive drug is the preparation of biological key oral liquid (021D1), embodiment 1 ~ 5 preparation.
2. laboratory animal: the male BALB/C mice (2011-0004) of selecting for use Jilin University's Experimental Animal Center to provide, clean animal, body weight 18 ~ 22g is by the body weight random packet.
3. experiment is divided into groups: embodiment 1 is equivalent to 9 times of human body recommended amounts by the dose,equivalent of mice is middle dose groups (0.075mL/10g); Middle dosage is high dose group (0.15mL/10g) for 2 times, and 1/2 of middle dosage is low dose group (0.0375mL/10g), and embodiment 2 ~ 5 sets up dose groups (0.075mL/10g) by embodiment 1; Positive drug is set up dose groups (0.075mL/10g); The blank group is irritated stomach distilled water (0.2mL/ only), and equal-volume is irritated stomach and tried thing 30 days continuously, measures each item index.
4. experimental apparatus: swimming case, galvanized wire, electronic balance, ELIASA, ultraviolet-uisible spectrophotometer, centrifuge, homogenizer.
5. experimental technique:
5.1 swimming test
Last gives mice and is tried thing after 30 minutes, and the galvanized wire of the negative mice body weight 3% of mouse tail root is put into water temperature and be 30 ℃, the swimming case of depth of water 35cm.All water temperature is transferred to 30 ℃ before the water under each batch mice.Put into 6 mices at every turn at most, begin time of exhausting to power with stopwatch record from swimming, this time is the swimming time of mice.
5.2 serum urea nitrogen determination
Last gives mice and is tried thing after 30 minutes, mice is put in the water of 30 ℃ of temperature swimming 90 minutes, plucks eyeball and gets blood, gets its value of determination of serum.
5.3 hepatic glycogen is measured
Last gives mice and is tried thing after 30 minutes, puts to death immediately.Get liver and after the normal saline rinsing, blot with filter paper, accurately take by weighing liver 200mg, add the trichloroacetic acid (TCA) of 4mL 5%, every pipe homogenate 1 minute is poured homogenate into centrifuge tube, 3000 rev/mins centrifugal 15 minutes, supernatant is transferred to another in vitro.In deposition, add 4mLTCA again, homogenate 1 minute, recentrifuge 15 minutes is got supernatant, and merges with for the first time centrifugal supernatant, fully mixing.Get the 1mL supernatant and put into the 10mL centrifuge tube, every pipe adds 95% ethanol 4mL, does not fully leave the interface between mixing to two kind of liquid.On clean plug, vertically place under the room temperature and spend the night.After deposition is complete, that test tube is centrifugal 15 minutes in 3000 rev/mins.Carefully outwell supernatant and test tube is stood upside down and placed 10 minutes.With 2mL dissolved in distilled water glycogen, the glycogen with tube wall when adding water washes, and makes it to dissolve fully.
Test tube is blank: inhale the 2mL distilled water to clean centrifuge tube.
Standard pipe: 0.5mL glucose titer (containing the 100mg/dL glucose) and 1.5mL distilled water are put into same centrifuge tube.
Measure: the 10mL anthrone reagent is firmly added each pipe, and liquid stream directly gets into pipe central authorities, guarantees fully to mix.From pipe, inject anthrone reagent, pipe put into cold water, reach cold water temperature after, it was immersed boiling water bath 15 minutes, move on to psychrolusia then, cool to room temperature.Liquid in pipe is moved into cuvette, and the 620nm wavelength is with the absorbance of reagent blank zeroing back working sample pipe and standard pipe.Be converted into hepatic glycogen content (representing) according to liver weight with the mg/g liver.
5.4 blood lactic acid is measured
Last gives mice and is tried thing after 30 minutes, puts into the swimming case swimming of 30 ℃ of water temperatures, depth of water 35cm and takes out after 10 minutes, adopts tail blood 20uL at once, adds mixing in the test tube that fills the 40uL hemolytic agent, with bio-sensing analysis-e/or determining blood lactic acid value.Adopting uses the same method measures before the swimming and the swimming back blood lactate level 20 minutes time of having a rest.
6. experimental result: experimental data is carried out statistical analysis.
Experimental result is following:
1) swimming test: like table 1
Table 1 is respectively organized mice swimming time result
2) serum urea nitrogen determination: like table 2
Table 2 is respectively organized mice serum determination of urea nitrogen result
3) hepatic glycogen is measured: like table 3
Table 3 is respectively organized the Mouse Liver glycogen and is measured the result
4) blood lactic acid is measured: like table 4
Table 4 is respectively organized mice blood lactic acid and is measured the result
7. brief summary
Oral administration gives the compound preparation 30 days of mice various dose, can obviously prolong the mice swimming time, significantly reduces serum urea nitrogen behind the mouse movement, significantly improves the blood lactic acid removing speed behind the mouse movement, and increases the Mouse Liver glycogen content.According to the regulation of " the health food function assessment assessment process and the method for inspection ", functional food of the present invention has antifatigue effect.
Can find out that by experimental result generation that the present invention can fatigue alleviating and the elimination that can accelerate fatigue improve the situation of body, can reduce serum urea nitrogen and quicken to remove blood lactic acid, increase hepatic glycogen content, are the antifatigue ideal health care products.
Claims (3)
1. compound preparation with antifatigue effect is characterized in that mainly by following raw materials by weight portion than processing:
50 ~ 70 parts of Radix Ginsengs, 5 ~ 20 parts of the Radix Paeoniae Albas, 65 ~ 80 parts of Rhizoma Zingiberiss, 10 ~ 25 parts on Cortex cinnamomi japonici (Ramulus Cinnamomi), 5 ~ 20 parts of Pericarpium Citri Reticulataes, 25 ~ 40 parts in Fructus Jujubae, 3 ~ 20 parts of Radix Angelicae Sinensis, 10 ~ 25 parts in Radix Glycyrrhizae, taurine 0.2 ~ 1g/50mL preparation.
2. the compound preparation with antifatigue effect according to claim 1, its optimum ratio is:
60 parts of Radix Ginsengs, 12 parts of the Radix Paeoniae Albas, 70 parts of Rhizoma Zingiberiss, 15 parts on Cortex cinnamomi japonici (Ramulus Cinnamomi), 10 parts of Pericarpium Citri Reticulataes, 30 parts in Fructus Jujubae, 6 parts of Radix Angelicae Sinensis, 12 parts in Radix Glycyrrhizae, taurine 0.5g/50mL preparation.
3. according to the method for preparing of the compound preparation with antifatigue effect of claim 1 or claim 2, may further comprise the steps:
1) take by weighing Radix Ginseng, the Radix Paeoniae Alba, Rhizoma Zingiberis, Cortex cinnamomi japonici (Ramulus Cinnamomi), Pericarpium Citri Reticulatae in proportion, add 60% alcohol reflux 2 ~ 3 hours of 6 ~ 8 times of weight, extract altogether 2 times,, merge the alcohol extract that extracts for 2 times with sieve elimination medicinal residues,, subsequent use in the water-bath Back stroke to there not being the alcohol flavor;
2) take by weighing Fructus Jujubae, Radix Angelicae Sinensis, Radix Glycyrrhizae in proportion, the water logging that adds 6 ~ 8 times of weight was steeped 2 ~ 3 hours, carried out reflux, extract, 2 ~ 3 hours, extracted altogether 3 times, with sieve elimination medicinal residues, merged the water extract of 3 extractions, and is subsequent use;
3) medicinal liquid of combining step 1 and step 2 is concentrated into 1/4 of cumulative volume, sucking filtration, and filtrating adds dehydrated alcohol to 50% determining alcohol to remove impurity, and room temperature leaves standstill 48h;
4) medicinal liquid with step 3 carries out sucking filtration, and filtrating places the water-bath Back stroke not distinguish the flavor of to there being alcohol, sucking filtration, and filtrating adds dehydrated alcohol to 75% determining alcohol to remove impurity, cold preservation 48h;
5) medicinal liquid behind step 4 precipitate with ethanol is carried out sucking filtration, filtrating places the water-bath Back stroke not distinguish the flavor of to there being alcohol, sucking filtration, and filtrating adds 2.5 times water, boils 10min, is cooled to room temperature, cold preservation 48h;
6) medicinal liquid that extracts the step 5 contain crude drug amount 2.15 grams is diluted to 50mL, adds 500mg taurine, 5mg vitamin B then
2, the 20mg vitamin B
3, the 5mg vitamin B
6, add 5mg sucrose, 0.5mL glycerol, 20mg potassium sorbate, 150mg polyvinylpyrrolidone, 1g polyoxyethylene hydrogenated Oleum Ricini, transfer pH to 3～4 to process preparation of the present invention with citric acid.
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103006903A (en) * | 2012-12-22 | 2013-04-03 | 北华大学 | Compound preparation with anti-ageing effect |
| CN105167070A (en) * | 2015-02-02 | 2015-12-23 | 武汉草本立方科技发展有限公司 | Herbal compound Chinese medicinal drink for enhancing human immunity and alleviating body fatigue |
| CN105341612A (en) * | 2015-12-02 | 2016-02-24 | 广东橘香斋陈皮有限公司 | Herbal energy solid drink and preparation method and use thereof |
| CN109258996A (en) * | 2018-03-23 | 2019-01-25 | 山东中医药大学 | A kind of functional beverage for alleviating muscle after exercise pain |
| CN111802541A (en) * | 2020-07-27 | 2020-10-23 | 中国药科大学 | Traditional Chinese medicine plant beverage and preparation method thereof |
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| CN1803015A (en) * | 2005-01-11 | 2006-07-19 | 山东科尔生物医药科技开发有限公司 | Preparation method of health food with immune regulation and anti-fatigue function |
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- 2012-06-18 CN CN201210198977XA patent/CN102688471B/en not_active Expired - Fee Related
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| CN1803015A (en) * | 2005-01-11 | 2006-07-19 | 山东科尔生物医药科技开发有限公司 | Preparation method of health food with immune regulation and anti-fatigue function |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103006903A (en) * | 2012-12-22 | 2013-04-03 | 北华大学 | Compound preparation with anti-ageing effect |
| CN105167070A (en) * | 2015-02-02 | 2015-12-23 | 武汉草本立方科技发展有限公司 | Herbal compound Chinese medicinal drink for enhancing human immunity and alleviating body fatigue |
| CN105341612A (en) * | 2015-12-02 | 2016-02-24 | 广东橘香斋陈皮有限公司 | Herbal energy solid drink and preparation method and use thereof |
| CN109258996A (en) * | 2018-03-23 | 2019-01-25 | 山东中医药大学 | A kind of functional beverage for alleviating muscle after exercise pain |
| CN111802541A (en) * | 2020-07-27 | 2020-10-23 | 中国药科大学 | Traditional Chinese medicine plant beverage and preparation method thereof |
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| CN102688471B (en) | 2013-11-13 |
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