CN102688471B - Compound preparation for preventing fatigue - Google Patents
Compound preparation for preventing fatigue Download PDFInfo
- Publication number
- CN102688471B CN102688471B CN201210198977XA CN201210198977A CN102688471B CN 102688471 B CN102688471 B CN 102688471B CN 201210198977X A CN201210198977X A CN 201210198977XA CN 201210198977 A CN201210198977 A CN 201210198977A CN 102688471 B CN102688471 B CN 102688471B
- Authority
- CN
- China
- Prior art keywords
- parts
- alcohol
- radix
- water
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The invention provides a compound preparation for preventing fatigue, which mainly comprises ginseng, white peony root, dried ginger, cassia bark, dried tangerine peel, Chinese date, Chinese angelica, liquorice, taurine and the like. The compound preparation has scientific compatibility, small toxic and toxic effect, good taste and easy absorption by human bodies, so that the fatigue symptom can be remarkably improved, and the body immunity can be increased.
Description
Technical field:
The invention provides a kind of compound preparation with antifatigue effect, belong to the medical health product technical field.
Background technology:
Along with the development of society, the enhancing of high efficiency work, allegro life, competitive spirit, people's muscle power, mental in tension for a long time, directly cause chronic fatigue syndrome to occur, and the patient who is chief complaint with fatigue is clinically increased increasingly.Fatigue refers to body under the certain environment condition, the temporarily-depressed a kind of Physiological Psychology phenomenon of work efficiency that causes due to long-time or too heavy, nervous work (comprising mental and physical).Modern medicine thinks, the tired reason that produces is many-sided, and energy exhaustion is one of major reason.And the elimination of Fatique after Sports is the important problem that faces clinically.The effect of anti-fatigue medicament is exactly to want the generation of delay fatigue and the elimination that accelerates fatigue.For a long time, find safety, effectively, the medicine that has no side effect carrys out the generation of delay fatigue and the elimination that accelerates fatigue is one of focus of drug research always, motherland's traditional medicine is because of the characteristics such as its medicine-food two-purpose, adaptation population be extensive, the crowd who is very suitable for fatigue syndrome selects, and is boundless in the application prospect in this field.
Summary of the invention:
The invention provides a kind of compound preparation with antifatigue effect, have that flavour of a drug are less, definite ingredients, nontoxic characteristics and the anti-fatigue health-caring function is arranged.
The present invention is the compound preparation with antifatigue effect, by following raw materials by weight portion than making:
50 ~ 70 parts of Radix Ginsengs, 5 ~ 20 parts of the Radix Paeoniae Albas, 65 ~ 80 parts of Rhizoma Zingiberiss, 10 ~ 25 parts, Cortex cinnamomi japonici (Ramulus Cinnamomi), 5 ~ 20 parts of Pericarpium Citri Reticulataes, 25 ~ 40 parts, Fructus Jujubae, 3 ~ 20 parts of Radix Angelicae Sinensis, 10 ~ 25 parts, Radix Glycyrrhizae, taurine 0.2 ~ 1g/50mL preparation.
Optimum ratio of the present invention is:
60 parts of Radix Ginsengs, 12 parts of the Radix Paeoniae Albas, 70 parts of Rhizoma Zingiberiss, 15 parts, Cortex cinnamomi japonici (Ramulus Cinnamomi), 10 parts of Pericarpium Citri Reticulataes, 30 parts, Fructus Jujubae, 6 parts of Radix Angelicae Sinensis, 12 parts, Radix Glycyrrhizae, taurine 0.5g/50mL preparation.
The present invention has the preparation technology of the functional food of antifatigue effect, comprises the following steps:
1) take in proportion Radix Ginseng, the Radix Paeoniae Alba, Rhizoma Zingiberis, Cortex cinnamomi japonici (Ramulus Cinnamomi), Pericarpium Citri Reticulatae, add 60% alcohol reflux 2 ~ 3 hours of 6 ~ 8 times of weight, extract altogether 2 times,, with sieve elimination medicinal residues, merges the alcohol extract that extracts for 2 times, in the water-bath Back stroke to without alcohol, distinguishing the flavor of, standby;
2) take in proportion Fructus Jujubae, Radix Angelicae Sinensis, Radix Glycyrrhizae, add the water soaking 2 ~ 3 hours of 6 ~ 8 times of weight, carried out reflux, extract, 2 ~ 3 hours, extract altogether 3 times,, with sieve elimination medicinal residues, merges the water extraction liquid of 3 extractions, standby;
3) medicinal liquid of combining step 1 and step 2, be concentrated into 1/4 of cumulative volume, sucking filtration, and filtrate adds dehydrated alcohol to 50% determining alcohol to remove impurity, the standing 48h of room temperature;
4) medicinal liquid of step 3 is carried out sucking filtration, filtrate is placed in the water-bath Back stroke to without alcohol, distinguishing the flavor of, sucking filtration, and filtrate adds dehydrated alcohol to 75% determining alcohol to remove impurity, cold preservation 48h;
5) medicinal liquid after step 4 precipitate with ethanol is carried out sucking filtration, filtrate is placed in the water-bath Back stroke to without alcohol, distinguishing the flavor of, sucking filtration, and filtrate adds the water of 2.5 times, boils 10min, is cooled to room temperature, cold preservation 48h;
6) medicinal liquid that extracts the step 5 contain crude drug amount 2.15 grams is diluted to 50mL, then adds 500mg taurine, 5mg vitamin B
2, the 20mg vitamin B
3, the 5mg vitamin B
6, add 5mg sucrose, 0.5mL glycerol, 20mg potassium sorbate, 150mg polyvinylpyrrolidone, 1g polyoxyethylene hydrogenated Oleum Ricini, transfer pH to 3～4 to make preparation of the present invention with citric acid.
Usage and dosage:1 times/day; 50mL/ time.
Indication:Can eliminate fast the muscular soreness and the feeling of fatigue that cause due to motion, the discharge of acceleration bodies intracellular metabolite material, and energy health invigorating, building body.
Prescription analysis:Utilize in the present invention
Radix GinsengFor the principal agent of large tonifying the spleen and stomach vigour, strengthening the body resistance, in conjunction with
The Radix Paeoniae AlbaRegulate immune effect and enhancing anoxia enduring and antioxidation, anti-fatigue ability,
Radix Angelicae SinensisAlso have the effects such as anti-hypoxia, antitumor, radioprotective, antalgic and inflammation relieving, can improve and control blood system, and can regulate body's immunity, enhancing human body immunity power.
Fructus JujubaeIn jujube polysaccharide effectively remove oxygen-derived free radicals in body, promote the macrophage TNF secretion, strengthen immune function of mice, non-activated mouse boosting cell is had the promotion proliferation function.
Rhizoma Zingiberis, Cortex cinnamomi japonici (Ramulus Cinnamomi)Have dispersing cold for relieving pain, warming the meridian and promoting blood circulation, mend the supporing yang effect of fire, can blood vessel dilating, and blood circulation promoting, strengthen the antifatigue effect of above-mentioned Chinese medicine.
Pericarpium Citri ReticulataeRegulating qi-flowing for strengthening spleen, in accent, dampness, reduce phlegm, and
Radix GlycyrrhizaeBut enhancing human body immunity power, can suppress gastric secretion, promote ulcer healing, and the gastrointestinal smooth muscle spasmolysis is arranged, but also antitumor and relieving cough and expelling phlegm can be in harmonious proportion the Xin Wen of said medicine, the property of drying, the effect of enhancing tonification.All medicines are compatibility each other, synergism, and
TaurineCan promote pituitary hormone secretion, the activation pancreatic function, improve the organism endocrine system mode, and can promote immunity of organisms and resisting fatigue, with Chinese medicine ingredients, jointly brings into play the effect of resisting fatigue.
Good effect of the present invention is:Compound preparation, the science compatibility, toxic and side effects is little, and mouthfeel is all good, is easily absorbed by the body, and significantly improves fatigue symptom, improves immunity of organisms.
Specifically be implemented as follows:
Embodiment 1
1) take Radix Ginseng 60g, Radix Paeoniae Alba 12g, Rhizoma Zingiberis 70g, Cortex cinnamomi japonici (Ramulus Cinnamomi) 15g, Pericarpium Citri Reticulatae 10g mixes, and adds 6 times of weight, 60% alcohol reflux 3 hours, extracts altogether 2 times,, with sieve elimination medicinal residues, merges the alcohol extract of 2 extractions, and is in the water-bath Back stroke to without the alcohol flavor, standby;
2) take Fructus Jujubae 30g, Radix Angelicae Sinensis 6g, Radix Glycyrrhizae 12g mixes, and adds 7 times of weight water soakings 3 hours, and reflux, extract, 2 hours, extract 3 times altogether,, with sieve elimination medicinal residues, merges the water extraction liquid of 3 extractions, and is standby;
3) combining step 1) with step 2) medicinal liquid, be concentrated into 1/4 of cumulative volume, sucking filtration, filtrate adds dehydrated alcohol to 50% determining alcohol to remove impurity, the standing 48h of room temperature;
4) medicinal liquid of step 3) is carried out sucking filtration, filtrate is placed in the water-bath Back stroke to without alcohol, distinguishing the flavor of, sucking filtration, and filtrate adds dehydrated alcohol to 75% determining alcohol to remove impurity, cold preservation 48h;
5) medicinal liquid after the step 4) precipitate with ethanol is carried out sucking filtration, filtrate is placed in the water-bath Back stroke to without alcohol, distinguishing the flavor of, sucking filtration, and filtrate adds the water of 2.5 times, boils 10min, is cooled to room temperature, cold preservation 48h;
6) medicinal liquid that extracts the step 5) contain crude drug amount 2.15 grams is diluted to 50mL, then adds 500mg taurine, vitamin B
25mg, vitamin B
320mg, vitamin B
65mg, add sucrose 5mg, glycerol 0.5mL, potassium sorbate 20mg, polyvinylpyrrolidone 150mg, polyoxyethylene hydrogenated Oleum Ricini 1g, citric acid to transfer pH to 3.8 to make preparation of the present invention.
Embodiment 2
1) take Radix Ginseng 55g, Radix Paeoniae Alba 10g, Rhizoma Zingiberis 65g, Cortex cinnamomi japonici (Ramulus Cinnamomi) 10g, Pericarpium Citri Reticulatae 15g mixes, and adds 7 times of weight, 60% alcohol reflux 3 hours, extracts altogether 2 times,, with sieve elimination medicinal residues, merges the alcohol extract of 2 extractions, and is in the water-bath Back stroke to without the alcohol flavor, standby;
2) take Fructus Jujubae 25g, Radix Angelicae Sinensis 10g, Radix Glycyrrhizae 10g mixes, and adds 6 times of weight water soakings 3 hours, and reflux, extract, 2 hours, extract 3 times altogether,, with sieve elimination medicinal residues, merges the water extraction liquid of 3 extractions, and is standby;
3) ~ 6) with embodiment 1 step 3) ~ 6).
Embodiment 3
1) take Radix Ginseng 70g, Radix Paeoniae Alba 15g, Rhizoma Zingiberis 75g, Cortex cinnamomi japonici (Ramulus Cinnamomi) 16g, Pericarpium Citri Reticulatae 12g mixes, and adds 8 times of weight, 60% alcohol reflux 3 hours, extracts altogether 2 times,, with sieve elimination medicinal residues, merges the alcohol extract of 2 extractions, and is in the water-bath Back stroke to without the alcohol flavor, standby;
2) take Fructus Jujubae 27g, Radix Angelicae Sinensis 5g, Radix Glycyrrhizae 10g mixes, and adds 8 times of weight water soakings 3 hours, and reflux, extract, 2 hours, extract 3 times altogether,, with sieve elimination medicinal residues, merges the water extraction liquid of 3 extractions, and is standby;
3) ~ 6) with embodiment 1 step 3) ~ 6).
Embodiment 4
1) take Radix Ginseng 70g, Radix Paeoniae Alba 20g, Rhizoma Zingiberis 70g, Cortex cinnamomi japonici (Ramulus Cinnamomi) 10g, Pericarpium Citri Reticulatae 14g mixes, and adds 6 times of weight, 60% alcohol reflux 3 hours, extracts altogether 2 times,, with sieve elimination medicinal residues, merges the alcohol extract of 2 extractions, and is in the water-bath Back stroke to without the alcohol flavor, standby;
2) take Fructus Jujubae 40g, Radix Angelicae Sinensis 7g, Radix Glycyrrhizae 24g mixes, and adds 7 times of weight water soakings 3 hours, and reflux, extract, 2 hours, extract 3 times altogether,, with sieve elimination medicinal residues, merges the water extraction liquid of 3 extractions, and is standby;
3) ~ 6) with embodiment 1 step 3) ~ 6).
Embodiment 5
1) take Radix Ginseng 66g, Radix Paeoniae Alba 17g, Rhizoma Zingiberis 75g, Cortex cinnamomi japonici (Ramulus Cinnamomi) 12g, Pericarpium Citri Reticulatae 9g mixes, and adds 7 times of weight, 60% alcohol reflux 3 hours, extracts altogether 2 times,, with sieve elimination medicinal residues, merges the alcohol extract of 2 extractions, and is in the water-bath Back stroke to without the alcohol flavor, standby;
2) take Fructus Jujubae 27g, Radix Angelicae Sinensis 10g, Radix Glycyrrhizae 25g mixes, and adds 7 times of weight water soakings 3 hours, and reflux, extract, 2 hours, extract 3 times altogether,, with sieve elimination medicinal residues, merges the water extraction liquid of 3 extractions, and is standby;
3) ~ 6) with embodiment 1 step 3) ~ 6).
Following pharmacological evaluation proof therapeutic effect of the present invention:
, by testing the beneficial effect of further elaboration functional food of the present invention, measure to determine the resisting fatigue effect of functional food by swimming time, Serum Indexes, hepatic glycogen.
1, experimental drug: positive drug is the preparation of biological key oral liquid (021D1), embodiment 1 ~ 5 preparation.
2. laboratory animal: the male BALB/C mice (2011-0004) of selecting Jilin University's Experimental Animal Center to provide, clean animal, body weight 18 ~ 22g, by the body weight random packet.
3. experiment grouping: embodiment 1 is equivalent to 9 times of human body recommended amounts by the dose,equivalent of mice is middle dosage group (0.075mL/10g), 2 times of middle dosage are high dose group (0.15mL/10g), 1/2 of middle dosage is low dose group (0.0375mL/10g), embodiment 2 ~ 5 sets up dosage group (0.075mL/10g) by embodiment 1, positive drug is set up dosage group (0.075mL/10g), blank group gavage distilled water (0.2mL/ only), equal-volume gavage tested material is 30 days continuously, measures indices.
4. experimental apparatus: swimming trunk, galvanized wire, electronic balance, microplate reader, ultraviolet-uisible spectrophotometer, centrifuge, homogenizer.
5. experimental technique:
5.1 swimming test
Last gave the mice tested material after 30 minutes, and the galvanized wire of the negative Mouse Weight 3% of mouse tail root is put into water temperature and be 30 ℃, the swimming trunk of depth of water 35cm.All water temperature is transferred to 30 ℃ before water under every a collection of mice.Put at most 6 mices at every turn, with the stopwatch record, from swimming, start the time that exhausts to power, this time is the swimming time of mice.
5.2 serum urea nitrogen determination
Last gave the mice tested material after 30 minutes, mice was put in the water went swimming 90 minutes of 30 ℃ of temperature, plucked eyeball and got blood, got its value of determination of serum.
5.3 hepatic glycogen is measured
Last gave the mice tested material after 30 minutes, put to death immediately.Get liver and blot with filter paper after the normal saline rinsing, accurately take liver 200mg, add the trichloroacetic acid (TCA) of 4mL 5%, every pipe homogenate 1 minute, pour homogenate into centrifuge tube, 3000 rev/mins centrifugal 15 minutes, supernatant is transferred to another in vitro.Add again 4mLTCA in precipitation, homogenate 1 minute, recentrifuge 15 minutes, get supernatant, and with centrifugal for the first time supernatant, merge, and fully mixes.Get the 1mL supernatant and put into the 10mL centrifuge tube, every pipe adds 95% ethanol 4mL, fully mixes between two kinds of liquid and does not leave interface.With clean stopper beyond the Great Wall, vertically place and spend the night under room temperature.After precipitation is complete, that test tube is centrifugal 15 minutes in 3000 rev/mins.Carefully outwell supernatant and test tube is stood upside down and placed 10 minutes.Dissolve glycogen with the 2mL distilled water, while adding water, the glycogen of tube wall is washed down, make it to dissolve fully.
Test tube is blank: inhale the 2mL distilled water to clean centrifuge tube.
Standard pipe: 0.5mL glucose titer (containing the 100mg/dL glucose) and 1.5mL distilled water are put into same centrifuge tube.
Measure: the 10mL anthrone reagent is firmly added each pipe, and liquid stream directly enters pipe central authorities, guarantees fully to mix.From injecting anthrone reagent pipe, pipe is put into cold water, after reaching cold water temperature, it was immersed boiling water bath 15 minutes, then move on to psychrolusia, cool to room temperature.Liquid in pipe is moved into cuvette, and the 620nm wavelength, with the absorbance of working sample pipe and standard pipe after the reagent blank zeroing.Be converted into hepatic glycogen content (with the mg/g liver, representing) according to liver weight.
5.4 blood Plasma lactate
Last gave the mice tested material after 30 minutes, and the swimming trunk went swimming of putting into 30 ℃ of water temperatures, depth of water 35cm took out after 10 minutes, at once adopted tail blood 20uL, added in the test tube that fills the 40uL hemolytic agent and mixed, with bio-sensing analysis-e/or determining blood Lactate.Adopting the mensuration that uses the same method swims front and the blood lactate level of the rear rest of swimming in the time of 20 minutes.
6. experimental result: experimental data is carried out statistical analysis.
Experimental result is as follows:
1) swimming test: as table 1
Table 1 is respectively organized mice swimming time result
2) serum urea nitrogen determination: as table 2
Table 2 is respectively organized mice serum determination of urea nitrogen result
3) hepatic glycogen is measured: as table 3
Table 3 is respectively organized Mouse Liver glycogen measurement result
4) blood Plasma lactate: as table 4
Table 4 is respectively organized Mouse Blood Plasma lactate result
7. brief summary
Oral administration gives the compound preparation 30 days of mice various dose, can obviously extend the mice swimming time, significantly reduces serum urea nitrogen after mouse movement, significantly improves the blood lactic acid removing speed after mouse movement, and increases the Mouse Liver glycogen content.According to the regulation of " function of health food is learned assessment process and the method for inspection ", functional food of the present invention has antifatigue effect.
Can be found out by experimental result, the generation of energy fatigue alleviating of the present invention and the elimination that can accelerate fatigue, improve the situation of body, can reduce serum urea nitrogen and accelerate to remove blood lactic acid, increases hepatic glycogen content, is the ideal health care product of resisting fatigue.
Claims (3)
1. compound preparation with antifatigue effect it is characterized in that by following raw materials by weight portion than making:
50 ~ 70 parts of Radix Ginsengs, 5 ~ 20 parts of the Radix Paeoniae Albas, 65 ~ 80 parts of Rhizoma Zingiberiss, 10 ~ 25 parts, Cortex cinnamomi japonici (Ramulus Cinnamomi), 5 ~ 20 parts of Pericarpium Citri Reticulataes, 25 ~ 40 parts, Fructus Jujubae, 3 ~ 20 parts of Radix Angelicae Sinensis, 10 ~ 25 parts, Radix Glycyrrhizae, taurine 0.2 ~ 1g/50mL preparation.
2. the compound preparation with antifatigue effect according to claim 1 it is characterized in that by following raw materials by weight portion than making:
60 parts of Radix Ginsengs, 12 parts of the Radix Paeoniae Albas, 70 parts of Rhizoma Zingiberiss, 15 parts, Cortex cinnamomi japonici (Ramulus Cinnamomi), 10 parts of Pericarpium Citri Reticulataes, 30 parts, Fructus Jujubae, 6 parts of Radix Angelicae Sinensis, 12 parts, Radix Glycyrrhizae, taurine 0.5g/50mL preparation.
3. comprise the following steps according to claim 1 or the preparation method of the compound preparation with antifatigue effect of claim 2:
1) take in proportion Radix Ginseng, the Radix Paeoniae Alba, Rhizoma Zingiberis, Cortex cinnamomi japonici (Ramulus Cinnamomi), Pericarpium Citri Reticulatae, add 60% alcohol reflux 2 ~ 3 hours of 6 ~ 8 times of weight, extract altogether 2 times,, with sieve elimination medicinal residues, merges the alcohol extract that extracts for 2 times, in the water-bath Back stroke to without alcohol, distinguishing the flavor of, standby;
2) take in proportion Fructus Jujubae, Radix Angelicae Sinensis, Radix Glycyrrhizae, add the water soaking 2 ~ 3 hours of 6 ~ 8 times of weight, carried out reflux, extract, 2 ~ 3 hours, extract altogether 3 times,, with sieve elimination medicinal residues, merges the water extraction liquid of 3 extractions, standby;
3) medicinal liquid of combining step 1 and step 2, be concentrated into 1/4 of cumulative volume, sucking filtration, and filtrate adds dehydrated alcohol to 50% determining alcohol to remove impurity, the standing 48h of room temperature;
4) medicinal liquid of step 3 is carried out sucking filtration, filtrate is placed in the water-bath Back stroke to without alcohol, distinguishing the flavor of, sucking filtration, and filtrate adds dehydrated alcohol to 75% determining alcohol to remove impurity, cold preservation 48h;
5) medicinal liquid after step 4 precipitate with ethanol is carried out sucking filtration, filtrate is placed in the water-bath Back stroke to without alcohol, distinguishing the flavor of, sucking filtration, and filtrate adds the water of 2.5 times, boils 10min, is cooled to room temperature, cold preservation 48h;
6) medicinal liquid that extracts the step 5 contain crude drug amount 2.15 grams is diluted to 50mL, then adds 500mg taurine, 5mg vitamin B
2, the 20mg vitamin B
3, the 5mg vitamin B
6, add 5mg sucrose, 0.5mL glycerol, 20mg potassium sorbate, 150mg polyvinylpyrrolidone, 1g polyoxyethylene hydrogenated Oleum Ricini, transfer pH to 3～4 to make preparation with citric acid.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210198977XA CN102688471B (en) | 2012-06-18 | 2012-06-18 | Compound preparation for preventing fatigue |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210198977XA CN102688471B (en) | 2012-06-18 | 2012-06-18 | Compound preparation for preventing fatigue |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102688471A CN102688471A (en) | 2012-09-26 |
| CN102688471B true CN102688471B (en) | 2013-11-13 |
Family
ID=46854315
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201210198977XA Expired - Fee Related CN102688471B (en) | 2012-06-18 | 2012-06-18 | Compound preparation for preventing fatigue |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102688471B (en) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103006903A (en) * | 2012-12-22 | 2013-04-03 | 北华大学 | Compound preparation with anti-ageing effect |
| CN105167070A (en) * | 2015-02-02 | 2015-12-23 | 武汉草本立方科技发展有限公司 | Herbal compound Chinese medicinal drink for enhancing human immunity and alleviating body fatigue |
| CN105341612A (en) * | 2015-12-02 | 2016-02-24 | 广东橘香斋陈皮有限公司 | Herbal energy solid drink and preparation method and use thereof |
| CN109258996A (en) * | 2018-03-23 | 2019-01-25 | 山东中医药大学 | A kind of functional beverage for alleviating muscle after exercise pain |
| CN111802541A (en) * | 2020-07-27 | 2020-10-23 | 中国药科大学 | Traditional Chinese medicine plant beverage and preparation method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1803015A (en) * | 2005-01-11 | 2006-07-19 | 山东科尔生物医药科技开发有限公司 | Preparation method of health food with immune regulation and anti-fatigue function |
-
2012
- 2012-06-18 CN CN201210198977XA patent/CN102688471B/en not_active Expired - Fee Related
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1803015A (en) * | 2005-01-11 | 2006-07-19 | 山东科尔生物医药科技开发有限公司 | Preparation method of health food with immune regulation and anti-fatigue function |
Non-Patent Citations (8)
| Title |
|---|
| 周宝宽.抗疲劳防治亚健康中药整理与研究.《中华中医药学刊》.2008,第26卷(第1期),193-195. |
| 张玉辉.补中益气汤合桂枝汤治疗慢性疲劳综合征体会.《中国中医药信息杂志》.2004,第11卷(第12期),1107. |
| 抗疲劳防治亚健康中药整理与研究;周宝宽;《中华中医药学刊》;20081231;第26卷(第1期);193-195 * |
| 李伟荣 * |
| 柯杰兵.牛磺酸代谢及其抗疲劳机理(综述).《解放军体育学院学报》.1999,第18卷(第3期),57-59. |
| 牛磺酸代谢及其抗疲劳机理(综述);柯杰兵;《解放军体育学院学报》;19991231;第18卷(第3期);57-59 * |
| 等.陈皮干姜油对疲劳大鼠血液生化、血气分析及肌糖元的影响.《中药药理与临床》.2010,第26卷(第1期),57-59. * |
| 补中益气汤合桂枝汤治疗慢性疲劳综合征体会;张玉辉;《中国中医药信息杂志》;20041231;第11卷(第12期);1107 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN102688471A (en) | 2012-09-26 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102046185B (en) | Composition comprising 1, 3 /1, 6 beta glucan for reducing weight | |
| CN102688471B (en) | Compound preparation for preventing fatigue | |
| CN107853517B (en) | Traditional Chinese medicine beverage capable of refreshing and resisting fatigue and preparation method thereof | |
| CN104305453A (en) | American ginseng compounded anti-fatigue sports health beverage | |
| CN104706707A (en) | Antiviral immunity-enhancing ginseng healthcare product | |
| CN102048902B (en) | Hepatitis treating traditional Chinese medicine composition, extract and preparation method, application and formulation | |
| CN109528904A (en) | A kind of kidney-tonifying health-care, boosting qi and nourishing yin, pharmaceutical composition of high-content ginsenoside and preparation method thereof | |
| CN103301267A (en) | Traditional Chinese medicine composition for treating hypertension and/or atherosclerosis and application thereof | |
| CN107912773A (en) | A kind of preparation for being used to alleviate physical fatigue | |
| CN103977390B (en) | A kind of preparation method and its usage of ginger onion medicated wine composition | |
| CN102784230B (en) | Pharmaceutical composition preparation for treating nutritional anemia | |
| CN101317900B (en) | Chinese medicinal composition for preventing and controlling alcoholic liver damnification and preparation method thereof | |
| CN104491310B (en) | Anti-Fatigue Composition and its preparation method and application | |
| CN103181557A (en) | Nutritious food with slimming function and preparation method thereof | |
| CN105327115A (en) | Phellinus linteus catharsis formula for prevention and cure of type II diabetes and preparation process thereof | |
| CN103007145B (en) | Traditional Chinese medicine composition for treating children rotavirus enteritis and preparation method of composition | |
| CN105943833B (en) | Anti-fatigue traditional Chinese medicine health tea for physical exercise | |
| CN104997956A (en) | Behcet's syndrome and treatment drug thereof | |
| CN105062819B (en) | Tonifying kidney and strengthening yang health preserving wine | |
| CN108497225A (en) | A kind of plant beverage and preparation method with function of physical fatigue alleviation | |
| CN103750304A (en) | Weight-reducing, fat-reducing and health-protection rhizoma alismatis oral liquid and preparation method thereof | |
| CN102579713B (en) | Traditional Chinese medicine for treating children obesity and preparation method | |
| CN105327340A (en) | Anti-senility composition and preparation method thereof | |
| Kundrat | Herbs and athletes | |
| CN107753589B (en) | A Chinese medicinal composition for treating diabetes, and its preparation method |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20131113 Termination date: 20140618 |
|
| EXPY | Termination of patent right or utility model |