CN105327340A - Anti-senility composition and preparation method thereof - Google Patents

Anti-senility composition and preparation method thereof Download PDF

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Publication number
CN105327340A
CN105327340A CN201510822958.3A CN201510822958A CN105327340A CN 105327340 A CN105327340 A CN 105327340A CN 201510822958 A CN201510822958 A CN 201510822958A CN 105327340 A CN105327340 A CN 105327340A
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parts
radix
powder
senility
radix angelicae
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徐显琦
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Xinhui District Huicheng Meihe Trading Co
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Xinhui District Huicheng Meihe Trading Co
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/39—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/618—Molluscs, e.g. fresh-water molluscs, oysters, clams, squids, octopus, cuttlefish, snails or slugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232—Angelica
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/236—Ligusticum (licorice-root)
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/238—Saposhnikovia
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/34—Campanulaceae (Bellflower family)
    • A61K36/344—Codonopsis
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/41—Crassulaceae (Stonecrop family)
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484—Glycyrrhiza (licorice)
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    • A61K36/18—Magnoliophyta (angiosperms)
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    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/539—Scutellaria (skullcap)
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    • A61K36/18—Magnoliophyta (angiosperms)
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    • A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/736—Prunus, e.g. plum, cherry, peach, apricot or almond
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8968—Ophiopogon (Lilyturf)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
    • A61K36/8994—Coix (Job's tears)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A61K8/65—Collagen; Gelatin; Keratin; Derivatives or degradation products thereof
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A—HUMAN NECESSITIES
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    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
    • A61K8/987—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of species other than mammals or birds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
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    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
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    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
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    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction

Abstract

The invention discloses anti-senility composition and a preparation method thereof. The anti-senility composition comprises components in parts by weight as follows: pearl powder, almond powder, white peony roots, Chinese angelica, liquorice, dwarf lilyturf tubers, Szechuan lovage rhizomes, pubescent angelica roots, barley, divaricate saposhnikovia roots, radix codonopsis, rice bran, baical skullcap roots and rhodiola rosea. The preparation method comprises steps as follows: the components are ground into powder capable of being sieved by a 200-mesh screen and are added to water and ultrasonically boiled until the volume of a solution is 1/5 of that of a solvent before heating, and a precipitate is filtered out; mannitol accounting for 1/10 of the weight of the solution is added and stirred until dissolving; the anti-senility composition is obtained through filling. The anti-senility composition is a pure traditional Chinese medicine preparation, has the moderate medicinal property and is suitable for vast old people.

Description

A kind of anti-apolexis composition and preparation method thereof
Technical field
The present invention relates to field of medicaments, particularly a kind of oral liquid.
Background technology
As time goes on old and feeble (senility) refer to, the necessary process that life entity is spontaneous.Along with the progress of society, the life-span of crowd, old people's quantity continued to increase also in continuous prolongation.In a physiologically, aging is regarded as the ontogeny being performed until old age from germ cell.From pathology, aging stress and be strained, damage and infection, and immunoreation is failed, undernutrition, the result of dysbolismus and carelessness and abuse accumulation.Because the physical function of old people fails, some affect large medicine to hepatic and renal function and have been not suitable for old people and take, and therefore developing antiaging agent that a kind of property of medicine relaxes, pure Chinese medicinal preparation has very strong realistic meaning.
Summary of the invention
For above-mentioned technical problem, the invention provides a kind of anti-apolexis composition and preparation method thereof.Anti-apolexis composition of the present invention is made up of the component of following weight portion: Margarita powder 10 ~ 30 parts, Semen Armeniacae Amarum powder 30 ~ 50 parts, the Radix Paeoniae Alba 5 ~ 15 parts, Radix Angelicae Sinensis 10 ~ 20 parts, 30 ~ 50 parts, Radix Glycyrrhizae, Radix Ophiopogonis 5 ~ 15 parts, Rhizoma Chuanxiong 5 ~ 15 parts, Radix Angelicae Pubescentis 10 ~ 20 parts, Semen Coicis 10 ~ 20 parts, Radix Saposhnikoviae 10 ~ 20 parts, Radix Codonopsis 5 ~ 15 parts, 10 ~ 20 parts, Testa oryzae, collagen protein powder 10 ~ 20 parts, Radix Scutellariae 10 ~ 20 parts, Radix Rhodiolae 10 ~ 20 parts.
Further, be made up of the component of following weight portion: Margarita powder 15 ~ 25 parts, Semen Armeniacae Amarum powder 35 ~ 45 parts, the Radix Paeoniae Alba 8 ~ 12 parts, Radix Angelicae Sinensis 12 ~ 17 parts, 35 ~ 45 parts, Radix Glycyrrhizae, Radix Ophiopogonis 8 ~ 13 parts, Rhizoma Chuanxiong 9 ~ 12 parts, Radix Angelicae Pubescentis 13 ~ 18 parts, Semen Coicis 12 ~ 17 parts, Radix Saposhnikoviae 12 ~ 18 parts, Radix Codonopsis 8 ~ 13 parts, 12 ~ 18 parts, Testa oryzae, collagen protein powder 12 ~ 18 parts, Radix Scutellariae 12 ~ 18 parts, Radix Rhodiolae 12 ~ 18 parts.
Particularly, be made up of the component of following weight portion: Margarita powder 20 parts, Semen Armeniacae Amarum powder 40 parts, the Radix Paeoniae Alba 10 parts, Radix Angelicae Sinensis 15 parts, 40 parts, Radix Glycyrrhizae, Radix Ophiopogonis 10 parts, Rhizoma Chuanxiong 10 parts, Radix Angelicae Pubescentis 15 parts, Semen Coicis 15 parts, Radix Saposhnikoviae 15 parts, Radix Codonopsis 10 parts, 15 parts, Testa oryzae, collagen protein powder 15 parts, Radix Scutellariae 15 parts, Radix Rhodiolae 15 parts.
The preparation method of anti-apolexis composition of the present invention comprises the following steps:
(1). by formula ratio, the Radix Paeoniae Alba, Radix Angelicae Sinensis, Radix Glycyrrhizae, Radix Ophiopogonis, Rhizoma Chuanxiong, Radix Angelicae Pubescentis, Semen Coicis, Radix Saposhnikoviae, Radix Codonopsis, Testa oryzae, Radix Scutellariae and Radix Rhodiolae are shone dry grinding;
(2). add Margarita powder, Semen Armeniacae Amarum powder, mix homogeneously;
(3). mixed-powder obtained for step (2) is joined in the water of 5 times of weight, ultrasonic boil be heating to liquor capacity before solvent volume 1/5, elimination precipitates; Add the mannitol of solution weight 1/10, be stirred to dissolving;
(4). every bottle of 5ml fill and get final product.
Preferably, the Radix Paeoniae Alba after described pulverizing, Radix Angelicae Sinensis, Radix Glycyrrhizae, Radix Ophiopogonis, Rhizoma Chuanxiong, Radix Angelicae Pubescentis, Semen Coicis, Radix Saposhnikoviae, Radix Codonopsis, Testa oryzae, Radix Scutellariae, Radix Rhodiolae powder and Margarita powder and Semen Armeniacae Amarum powder are by 200 mesh sieves.
The purposes of anti-apolexis composition described in above-mentioned any one in the antidotal external use skin care of preparation or medicine.
In each component of the present invention:
Margarita has the effects such as arresting convulsion of calming the nerves, improving eyesight removing nebula, removing toxic substances and promoting granulation, and modern study also shows that Margarita powder is improving the effect all in body immunity, slow down aging, freckle removing and whitening, supplement calcium etc. with uniqueness.Compendium of Material Medica volume six or four is described below: " Margarita salty in the mouth, sweet cold nontoxic.Relieving palpitation point order.Painting face, makes us moist good color.Be coated with brothers, peeling skin hangnail, pendant expectorant, except speckle, stopping leak.Except children's's fever (of children) accompanied by fear, peace soul.Only to pass out semen nebulousurine, separate pox and treat poison.”
Semen Armeniacae Amarum powder, containing the nutrient that abundant cellulosic, phosphorus, ferrum, calcium, laetrile and unsaturated fatty acid etc. are important.Semen Armeniacae Amarum powder contains the almond oil of 49%, can skin care, and desalination mottle, makes skin delicate.
The Radix Paeoniae Alba, bitter in the mouth, acid, cold nature.Return liver, spleen channel.There is nourishing blood for regulating menstruation, astringing YIN to stop sweating, easing the affected liver to relieve pain, suppressing liver-YANG.Effect, cure mainly blood deficiency and yellow complexion, menoxenia, spontaneous perspiration, night sweat, hypochondriac pain, stomachache, limb pain twin, has a headache dizzy.
Radix Angelicae Sinensis, sweet in the mouth, pungent, warm in nature.Return liver, the heart, spleen channel.Having enriches blood invigorates blood circulation, menstruction regulating and pain relieving, effect of loosening bowel to relieve constipation.Cure mainly blood deficiency and yellow complexion, dizzy cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia etc.
Radix Glycyrrhizae, sweet in the mouth, property is put down.GUIXIN, lung, spleen, stomach warp.There is invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, effect of coordinating the actions of various ingredients in a prescription, for being in harmonious proportion the strong of some drugs.
Radix Ophiopogonis, " sweet, micro-hardship, is slightly cold.Main containing dwarf lilyturf glycosides, steroidal saponin, alkaloid, sitosterol, glucose, aminoacid, vitamin etc., there is resisting fatigue, scavenging free radicals, raising cellular immune function and hypoglycemic effect.In addition, the curative effect of calmness, hypnosis is had Radix Ophiopogonis.
Rhizoma Chuanxiong, acrid in the mouth, temperature; Enter liver, gallbladder meridian.Cure mainly menoxenia, dysmenorrhea, amenorrhea, difficult labour, retention of placenta, lochia is suffered from abdominal pain, lump etc.
Radix Angelicae Pubescentis: acrid in the mouth, hardship, slightly warm in nature.Return kidney, urinary bladder channel.Can expelling wind and removing dampness, arthralgia aggravated by cold pain relieving.Cure mainly anemofrigid-damp arthralgia, wash pain, few cloudy volt wind headache, wind and cold holds wet headache under the arm.
Semen Coicis: sweet in the mouth, light, cold nature.Return spleen; Lung; Kidney channel.Semen Coicis has certain antibacterial, antiviral efficacy.Long-term taking, can make skin smooth fine and smooth, fair and clear glossy.
Radix Saposhnikoviae: acrid in the mouth, sweet, slightly warm in nature.Return bladder, lung, spleen, Liver Channel.There is expelling pathogenic wind from the body surface, effect of removing dampness to relieve pain, for diseases caused by exogenous pathogenic factor exterior syndrome, rubella pruritus, rheumatic arthralgia, tetanus just, insufficiency of the spleen leading to overabundance of dampness.
Radix Codonopsis: sweet in the mouth is put down, nontoxic.Return spleen, lung meridian.Invigorating middle warmer, QI invigorating, promotes the production of body fluid.Control weakness of the spleen and stomach, deficiency of both QI and blood, fatigue and lack of strength.Contained by Radix Codonopsis, effective ingredient has excitation to nervous system, and energy enhancing body resistance, increases erythrocyte and hemoglobin.
Testa oryzae: bitter sweet, flat, nontoxic.Enter spleen, stomach warp.Effect that the ceramide glucoside contained in Testa oryzae has check melanin to generate. manufacture cosmetics with its and can protect skin wet, fair and clear.From Testa oryzae, extract ferulic acid, as food additive, there is the effect of absorption ultraviolet and anti-oxidation.
Radix Scutellariae: bitter in the mouth, cold in nature.Return lung, gallbladder, spleen, large intestine, small intestine meridian.There is heat clearing and damp drying, effect of eliminating fire and detoxication.Modern pharmacology test confirms, Radix Scutellariae has antiplatelet aggregation and anticoagulant, blood fat reducing, protects the liver, function of gallbladder promoting, antioxidation and the effect such as anticancer.
Radix Rhodiolae: sweet in the mouth, hardship, property is put down.Return lung, heart channel.Cure mainly blood stasis due to qi deficiency, obstruction of qi in the chest and cardialgia, apoplectic hemiplegia, asthenia is panted.
Compared with prior art, the present invention is pure Chinese medicinal preparation, and the property of medicine relaxes, and taste is fresh and sweet, but does not increase the intake of sugar, is easy to be accepted.There is scavenging free radicals, improve body's immunity, promote body metabolism, nervous system regulation function, thus delay degeneration and the aging course of people and internal organs physiological function, improve body constitution muscle power, improve spirit, reach the object of human body slow down aging, side effect is little, can long-term taking.Be applicable to numerous old peoples to use.
In order to understand better and implement, the following detailed description of the present invention.
Detailed description of the invention
preparation embodiment
The preparation method of anti-apolexis composition of the present invention comprises the following steps:
(1). by table 1 formula ratio, the Radix Paeoniae Alba, Radix Angelicae Sinensis, Radix Glycyrrhizae, Radix Ophiopogonis, Rhizoma Chuanxiong, Radix Angelicae Pubescentis, Semen Coicis, Radix Saposhnikoviae, Radix Codonopsis, Testa oryzae, Radix Scutellariae and Radix Rhodiolae are dried and is crushed to by 200 mesh sieves;
(2). add Margarita powder, Semen Armeniacae Amarum powder, mix homogeneously;
(3). mixed-powder obtained for step (2) is joined in the water of 5 times of weight, ultrasonic boil be heating to liquor capacity before solvent volume 1/5, elimination precipitates; Add the mannitol of solution weight 1/10, be stirred to dissolving;
(4). every bottle of 5ml fill and get final product.
The each component formula amount of < table 1, with parts by weight >
salidroside content measures embodiment
Carry out according to the mensuration of rhodioloside " in the health food " first method in " health food inspection and assessment technical specification ".
Rhodioloside standard solution: accurately take rhodioloside standard substance 0.02g, add and dissolve and be settled to 10ml.
Sample pretreating: take the obtained each 20ml of sample of embodiment 1 ~ 5 respectively in 50ml measuring bottle, first add 25ml methanol, after ultrasonic 10min by methanol constant volume to scale, mixing, then through 0.45 μm of membrane filtration, be need testing solution.
Chromatographic condition: chromatographic column is C18 post, 4.6 × 250 × 5 μm; Column temperature is room temperature; Determined wavelength 215nm; Mobile phase is methanol: 0.02mol/l sodium acetate solution=9:91; Flow velocity is 1.0ml/min.
Specification Curve of Increasing: configuration concentration is 0,0.01,0.02,0.05,0.2,0.5 μ g/ml rhodioloside standard solution respectively, analyzes, do standard curve with peak area to concentration under above-mentioned given chromatographic condition.
Test process: get 10 μ l standard solution and need testing solution injection liquid chromatography, qualitative with retention time, with sample peak area and standard comparing quantitative.
Computing formula: X=(A 1× C × V)/(A 2× m × 1000), wherein: X is the content of rhodioloside in sample, mg/g; A 1for test sample peak area; C is concentration of standard solution, μ g/ml; V is sample constant volume, ml; A 2for standard solution peak area; M is sample mass, g.Result is as table 2:
< shows 2>
effect example
1. on the impact of mouse immune organ.
Get the male KM mice 140 that body weight is 12-15, be divided into embodiment 1 ~ 5 group, commercially available product group and blank group totally 7 groups at random by body weight.Often organize 20 mices.Every day gastric infusion once, matched group gavage to the distilled water of same volume, continuous 7 days.Last administration is after 24 hours, puts to death animal, weigh and thymus, spleen weight, using the ratio of thymus or spleen weight (mg) and body weight (g) as thymus or Spleen coefficient.Result is as table 3:
< shows 3>
* be contrast with commercially available product group, p<0.05; #for contrasting with matched group, p<0.05
2. D-galactose is damaged to the impact of mice lipofuscin content and anti-oxidation function enzyme activity
Select three monthly ages healthy Kunming mouse male and female half and half totally 80,18 ~ 20g.Be divided into 8 groups at random: normal group, model group, commercially available product group, embodiment 1 ~ 5 group.Adopt single cage to raise, freely ingest and drinking-water, room temperature 18 ~ 20 DEG C, daylight lamp floor light, maintain illumination every day 12 hours.
With the 0.96%D-galactose of normal saline, 5mg/kg body weight, subcutaneous injection modeling, every day 1 time, continuous modeling 6 weeks.Dosing group per os gives different given the test agent, model group and normal group give same volume solvent, while giving given the test agent, except normal group, each group is continued to give same dose D-galactose subcutaneous injection, normal group subcutaneous injection normal saline, experiment terminates to put to death animal, surveys lipofuscin content and anti-oxidation function enzyme activity.Measurement result carries out statistical disposition, the results are shown in Table 4:
< shows 4>
* be contrast with commercially available product group, p<0.05; #for contrasting with model group, p<0.05
The present invention is not limited to above-mentioned embodiment, if do not depart from the spirit and scope of the present invention to various change of the present invention or distortion, if these are changed and distortion belongs within claim of the present invention and equivalent technologies scope, then the present invention is also intended to comprise these changes and distortion.

Claims (6)

1. an anti-apolexis composition, is characterized in that being made up of the component of following weight portion: Margarita powder 10 ~ 30 parts, Semen Armeniacae Amarum powder 30 ~ 50 parts, the Radix Paeoniae Alba 5 ~ 15 parts, Radix Angelicae Sinensis 10 ~ 20 parts, 30 ~ 50 parts, Radix Glycyrrhizae, Radix Ophiopogonis 5 ~ 15 parts, Rhizoma Chuanxiong 5 ~ 15 parts, Radix Angelicae Pubescentis 10 ~ 20 parts, Semen Coicis 10 ~ 20 parts, Radix Saposhnikoviae 10 ~ 20 parts, Radix Codonopsis 5 ~ 15 parts, 10 ~ 20 parts, Testa oryzae, Radix Scutellariae 10 ~ 20 parts, Radix Rhodiolae 1 ~ 5 part.
2. a kind of anti-apolexis composition according to claim 1, is characterized in that being made up of the component of following weight portion: Margarita powder 15 ~ 25 parts, Semen Armeniacae Amarum powder 35 ~ 45 parts, the Radix Paeoniae Alba 8 ~ 12 parts, Radix Angelicae Sinensis 12 ~ 17 parts, 35 ~ 45 parts, Radix Glycyrrhizae, Radix Ophiopogonis 8 ~ 13 parts, Rhizoma Chuanxiong 9 ~ 12 parts, Radix Angelicae Pubescentis 13 ~ 18 parts, Semen Coicis 12 ~ 17 parts, Radix Saposhnikoviae 12 ~ 18 parts, Radix Codonopsis 8 ~ 13 parts, 12 ~ 18 parts, Testa oryzae, Radix Scutellariae 12 ~ 18 parts, Radix Rhodiolae 2 ~ 4 parts.
3. a kind of anti-apolexis composition according to claim 2, is characterized in that being made up of the component of following weight portion: Margarita powder 20 parts, Semen Armeniacae Amarum powder 40 parts, the Radix Paeoniae Alba 10 parts, Radix Angelicae Sinensis 15 parts, 40 parts, Radix Glycyrrhizae, Radix Ophiopogonis 10 parts, Rhizoma Chuanxiong 10 parts, Radix Angelicae Pubescentis 15 parts, Semen Coicis 15 parts, Radix Saposhnikoviae 15 parts, Radix Codonopsis 10 parts, 15 parts, Testa oryzae, Radix Scutellariae 15 parts, Radix Rhodiolae 3 parts.
4. prepare a method for a kind of anti-apolexis composition as described in claims 1 to 3 any one, it is characterized in that comprising the following steps:
(1). by formula ratio, the Radix Paeoniae Alba, Radix Angelicae Sinensis, Radix Glycyrrhizae, Radix Ophiopogonis, Rhizoma Chuanxiong, Radix Angelicae Pubescentis, Semen Coicis, Radix Saposhnikoviae, Radix Codonopsis, Testa oryzae, Radix Scutellariae and Radix Rhodiolae are shone dry grinding;
(2). add Margarita powder, Semen Armeniacae Amarum powder, mix homogeneously;
(3). mixed-powder obtained for step (2) is joined in the water of 5 times of weight, ultrasonic boil be heating to liquor capacity before solvent volume 1/5, elimination precipitates; Add the mannitol of solution weight 1/10, be stirred to dissolving;
(4). every bottle of 5ml fill and get final product.
5. a kind of anti-apolexis composition according to claim 5, is characterized in that: the Radix Paeoniae Alba after described pulverizing, Radix Angelicae Sinensis, Radix Glycyrrhizae, Radix Ophiopogonis, Rhizoma Chuanxiong, Radix Angelicae Pubescentis, Semen Coicis, Radix Saposhnikoviae, Radix Codonopsis, Testa oryzae, Radix Scutellariae, Radix Rhodiolae powder and Margarita powder and Semen Armeniacae Amarum powder are by 200 mesh sieves.
6. the purposes of anti-apolexis composition described in claims 1 to 3 any one in the antidotal external use skin care of preparation or medicine.
CN201510822958.3A 2015-11-24 2015-11-24 Anti-senility composition and preparation method thereof Pending CN105327340A (en)

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