CN105288596A - Anti-aging combination and preparation method thereof - Google Patents
Anti-aging combination and preparation method thereof Download PDFInfo
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- CN105288596A CN105288596A CN201510824678.6A CN201510824678A CN105288596A CN 105288596 A CN105288596 A CN 105288596A CN 201510824678 A CN201510824678 A CN 201510824678A CN 105288596 A CN105288596 A CN 105288596A
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Abstract
The invention discloses an anti-aging combination and a preparation method thereof. The anti-aging combination is composed of the following ingredients in parts by weight: a pearl powder, an apricot kernel powder, radix paeoniae alba, radix polygonati officinalis, angelica sinensis, liquorice, radix ophiopogonis, peach kernel, rhizoma ligustici wallichii, radix angelicae tuhuo, coix seed, radix saposhnikoviae, codonopsis pilosula, rice bran, radix scutellariae, rhodiola rosea, and folium ginkgo. The preparation method comprises the steps: crushing all the ingredients into powder which can pass through a 200 mesh sieve, adding water, carrying out ultrasonic boiling until the solution volume is 1/5 that of a solvent before heating, and filtering to remove a precipitate; adding mannitol with the amount being 1/10 of the solution weight, and stirring until being dissolved; and filling to obtain the product. The anti-aging combination is a pure traditional Chinese medicine preparation, moreover, is dental in medicinal property, and is suitable for a vast number of old people to use.
Description
Technical field
The present invention relates to field of medicaments, particularly a kind of oral liquid.
Background technology
As time goes on old and feeble (senility) refer to, the necessary process that life entity is spontaneous.Along with the progress of society, the life-span of crowd, old people's quantity continued to increase also in continuous prolongation.In a physiologically, aging is regarded as the ontogeny being performed until old age from germ cell.From pathology, aging stress and be strained, damage and infection, and immunoreation is failed, undernutrition, the result of dysbolismus and carelessness and abuse accumulation.Because the physical function of old people fails, some affect large medicine to hepatic and renal function and have been not suitable for old people and take, and therefore developing antiaging agent that a kind of property of medicine relaxes, pure Chinese medicinal preparation has very strong realistic meaning.
Summary of the invention
For above-mentioned technical problem, the invention provides a kind of anti-apolexis composition and preparation method thereof.Anti-apolexis composition of the present invention is made up of the component of following weight portion: Margarita powder 10 ~ 30 parts, Semen Armeniacae Amarum powder 30 ~ 50 parts, the Radix Paeoniae Alba 5 ~ 15 parts, Rhizoma Polygonati Odorati 5 ~ 15 parts, Radix Angelicae Sinensis 10 ~ 20 parts, 30 ~ 50 parts, Radix Glycyrrhizae, Radix Ophiopogonis 5 ~ 15 parts, 30 ~ 50 parts, Semen Persicae, Rhizoma Chuanxiong 5 ~ 15 parts, Radix Angelicae Pubescentis 10 ~ 20 parts, Semen Coicis 10 ~ 20 parts, Radix Saposhnikoviae 10 ~ 20 parts, Radix Codonopsis 5 ~ 15 parts, 10 ~ 20 parts, Testa oryzae, collagen protein powder 10 ~ 20 parts, Radix Scutellariae 10 ~ 20 parts, Radix Rhodiolae 10 ~ 20 parts, Folium Ginkgo 5 ~ 15 parts.
Further, be made up of the component of following weight portion: Margarita powder 15 ~ 25 parts, Semen Armeniacae Amarum powder 35 ~ 45 parts, the Radix Paeoniae Alba 8 ~ 12 parts, Rhizoma Polygonati Odorati 8 ~ 12 parts, Radix Angelicae Sinensis 12 ~ 17 parts, 35 ~ 45 parts, Radix Glycyrrhizae, Radix Ophiopogonis 8 ~ 13 parts, 35 ~ 45 parts, Semen Persicae, Rhizoma Chuanxiong 9 ~ 12 parts, Radix Angelicae Pubescentis 13 ~ 18 parts, Semen Coicis 12 ~ 17 parts, Radix Saposhnikoviae 12 ~ 18 parts, Radix Codonopsis 8 ~ 13 parts, 12 ~ 18 parts, Testa oryzae, collagen protein powder 12 ~ 18 parts, Radix Scutellariae 12 ~ 18 parts, Radix Rhodiolae 12 ~ 18 parts, Folium Ginkgo 8 ~ 13 parts.
Particularly, be made up of the component of following weight portion: Margarita powder 20 parts, Semen Armeniacae Amarum powder 40 parts, the Radix Paeoniae Alba 10 parts, Rhizoma Polygonati Odorati 10 parts, Radix Angelicae Sinensis 15 parts, 40 parts, Radix Glycyrrhizae, Radix Ophiopogonis 10 parts, 40 parts, Semen Persicae, Rhizoma Chuanxiong 10 parts, Radix Angelicae Pubescentis 15 parts, Semen Coicis 15 parts, Radix Saposhnikoviae 15 parts, Radix Codonopsis 10 parts, 15 parts, Testa oryzae, collagen protein powder 15 parts, Radix Scutellariae 15 parts, Radix Rhodiolae 15 parts, Folium Ginkgo 10 parts.
The preparation method of anti-apolexis composition of the present invention comprises the following steps:
(1). by formula ratio, the Radix Paeoniae Alba, Rhizoma Polygonati Odorati, Radix Angelicae Sinensis, Radix Glycyrrhizae, Radix Ophiopogonis, Semen Persicae, Rhizoma Chuanxiong, Radix Angelicae Pubescentis, Semen Coicis, Radix Saposhnikoviae, Radix Codonopsis, Testa oryzae, Radix Scutellariae, Radix Rhodiolae and Folium Ginkgo are shone dry grinding;
(2). add Margarita powder, Semen Armeniacae Amarum powder, mix homogeneously;
(3). mixed-powder obtained for step (2) is joined in the water of 5 times of weight, ultrasonic boil be heating to liquor capacity before solvent volume 1/5, elimination precipitates; Add the mannitol of solution weight 1/10, be stirred to dissolving;
(4). every bottle of 5ml fill and get final product.
Preferably, the Radix Paeoniae Alba after described pulverizing, Rhizoma Polygonati Odorati, Radix Angelicae Sinensis, Radix Glycyrrhizae, Radix Ophiopogonis, Semen Persicae, Rhizoma Chuanxiong, Radix Angelicae Pubescentis, Semen Coicis, Radix Saposhnikoviae, Radix Codonopsis, Testa oryzae, Radix Scutellariae, Radix Rhodiolae and Ginkgo Leaf and Margarita powder and Semen Armeniacae Amarum powder are by 200 mesh sieves.
The purposes of anti-apolexis composition described in above-mentioned any one in the antidotal external use skin care of preparation or medicine.
In each component of the present invention:
Margarita has the effects such as arresting convulsion of calming the nerves, improving eyesight removing nebula, removing toxic substances and promoting granulation, and modern study also shows that Margarita powder is improving the effect all in body immunity, slow down aging, freckle removing and whitening, supplement calcium etc. with uniqueness.Compendium of Material Medica volume six or four is described below: " Margarita salty in the mouth, sweet cold nontoxic.Relieving palpitation point order.Painting face, makes us moist good color.Be coated with brothers, peeling skin hangnail, pendant expectorant, except speckle, stopping leak.Except children's's fever (of children) accompanied by fear, peace soul.Only to pass out semen nebulousurine, separate pox and treat poison.”
Semen Armeniacae Amarum powder, containing the nutrient that abundant cellulosic, phosphorus, ferrum, calcium, laetrile and unsaturated fatty acid etc. are important.Semen Armeniacae Amarum powder contains the almond oil of 49%, can skin care, and desalination mottle, makes skin delicate.
The Radix Paeoniae Alba, bitter in the mouth, acid, cold nature.Return liver, spleen channel.There is nourishing blood for regulating menstruation, astringing YIN to stop sweating, easing the affected liver to relieve pain, suppressing liver-YANG.Effect, cure mainly blood deficiency and yellow complexion, menoxenia, spontaneous perspiration, night sweat, hypochondriac pain, stomachache, limb pain twin, has a headache dizzy.
Rhizoma Polygonati Odorati, introduces in Compendium of Material Medica: Rhizoma Polygonati Odorati, and property is put down, and sweet in the mouth is soft and moist edible.Therefore Zhu's upper arm " book of Nanyang for life saving " controls pathogenic wind-warm spontaneous perspiration heavy sensation of the body, dysphasia, with Rhizoma Polygonati Odorati soup with for monarch drug.Give often with the disease controlling asthenia cold and heat, Malaria malaria and all deficiencies, with for ginseng, stilbene, cold not dry, there is distinguished service greatly.Do not terminate in wind heat noxious dampness, this former times people person of not explaining also." curing mainly lung stomach-Yin wound, cough caused by dryness-heat, dry throat and mouth, interior-heat is quenched one's thirst.
Radix Angelicae Sinensis, sweet in the mouth, pungent, warm in nature.Return liver, the heart, spleen channel.Having enriches blood invigorates blood circulation, menstruction regulating and pain relieving, effect of loosening bowel to relieve constipation.Cure mainly blood deficiency and yellow complexion, dizzy cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia etc.
Radix Glycyrrhizae, sweet in the mouth, property is put down.GUIXIN, lung, spleen, stomach warp.There is invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, effect of coordinating the actions of various ingredients in a prescription, for being in harmonious proportion the strong of some drugs.
Radix Ophiopogonis, " sweet, micro-hardship, is slightly cold.Main containing dwarf lilyturf glycosides, steroidal saponin, alkaloid, sitosterol, glucose, aminoacid, vitamin etc., there is resisting fatigue, scavenging free radicals, raising cellular immune function and hypoglycemic effect.In addition, the curative effect of calmness, hypnosis is had Radix Ophiopogonis.
Semen Persicae, property is put down, bitter in the mouth, sweet.GUIXIN, liver, large intestine channel.There is blood circulation promoting and blood stasis dispelling, loosening bowel to relieve constipation, relieving cough and asthma.For amenorrhea dysmenorrhea, abdominal mass abdominal mass mass in the abdomen, lung abscess acute appendicitis, injury from falling down, dryness of the intestine constipation, cough and asthma.
Rhizoma Chuanxiong, acrid in the mouth, temperature; Enter liver, gallbladder meridian.Cure mainly menoxenia, dysmenorrhea, amenorrhea, difficult labour, retention of placenta, lochia is suffered from abdominal pain, lump etc.
Radix Angelicae Pubescentis: acrid in the mouth, hardship, slightly warm in nature.Return kidney, urinary bladder channel.Can expelling wind and removing dampness, arthralgia aggravated by cold pain relieving.Cure mainly anemofrigid-damp arthralgia, wash pain, few cloudy volt wind headache, wind and cold holds wet headache under the arm.
Semen Coicis: sweet in the mouth, light, cold nature.Return spleen; Lung; Kidney channel.Semen Coicis has certain antibacterial, antiviral efficacy.Long-term taking, can make skin smooth fine and smooth, fair and clear glossy.
Radix Saposhnikoviae: acrid in the mouth, sweet, slightly warm in nature.Return bladder, lung, spleen, Liver Channel.There is expelling pathogenic wind from the body surface, effect of removing dampness to relieve pain, for diseases caused by exogenous pathogenic factor exterior syndrome, rubella pruritus, rheumatic arthralgia, tetanus just, insufficiency of the spleen leading to overabundance of dampness.
Radix Codonopsis: sweet in the mouth is put down, nontoxic.Return spleen, lung meridian.Invigorating middle warmer, QI invigorating, promotes the production of body fluid.Control weakness of the spleen and stomach, deficiency of both QI and blood, fatigue and lack of strength.Contained by Radix Codonopsis, effective ingredient has excitation to nervous system, and energy enhancing body resistance, increases erythrocyte and hemoglobin.
Testa oryzae: bitter sweet, flat, nontoxic.Enter spleen, stomach warp.Effect that the ceramide glucoside contained in Testa oryzae has check melanin to generate. manufacture cosmetics with its and can protect skin wet, fair and clear.From Testa oryzae, extract ferulic acid, as food additive, there is the effect of absorption ultraviolet and anti-oxidation.
Radix Scutellariae: bitter in the mouth, cold in nature.Return lung, gallbladder, spleen, large intestine, small intestine meridian.There is heat clearing and damp drying, effect of eliminating fire and detoxication.Modern pharmacology test confirms, Radix Scutellariae has antiplatelet aggregation and anticoagulant, blood fat reducing, protects the liver, function of gallbladder promoting, antioxidation and the effect such as anticancer.
Radix Rhodiolae: sweet in the mouth, hardship, property is put down.Return lung, heart channel.Cure mainly blood stasis due to qi deficiency, obstruction of qi in the chest and cardialgia, apoplectic hemiplegia, asthenia is panted.
Folium Ginkgo: sweet in the mouth, hardship, property is put down.GUIXIN, lung meridian.Can blood circulation promoting and blood stasis dispelling, removing obstruction in the collateral to relieve pain, astringe the lung and relieving asthma, change turbid blood fat reducing.For obstruction of collaterals by blood stasis, obstruction of qi in the chest and cardialgia, apoplectic hemiplegia, cough and asthma due to lung deficiency, hyperlipidemia.
Compared with prior art, the present invention is pure Chinese medicinal preparation, and the property of medicine relaxes, and taste is fresh and sweet, but does not increase the intake of sugar, is easy to be accepted.There is scavenging free radicals, improve body's immunity, promote body metabolism, nervous system regulation function, thus delay degeneration and the aging course of people and internal organs physiological function, improve body constitution muscle power, improve spirit, reach the object of human body slow down aging, side effect is little, can long-term taking.Be applicable to numerous old peoples to use.
In order to understand better and implement, the following detailed description of the present invention.
Detailed description of the invention
preparation embodiment
The preparation method of anti-apolexis composition of the present invention comprises the following steps:
(1). by table 1 formula ratio, the Radix Paeoniae Alba, Rhizoma Polygonati Odorati, Radix Angelicae Sinensis, Radix Glycyrrhizae, Radix Ophiopogonis, Semen Persicae, Rhizoma Chuanxiong, Radix Angelicae Pubescentis, Semen Coicis, Radix Saposhnikoviae, Radix Codonopsis, Testa oryzae, Radix Scutellariae, Radix Rhodiolae and Folium Ginkgo are dried and is crushed to by 200 mesh sieves;
(2). add Margarita powder, Semen Armeniacae Amarum powder, mix homogeneously;
(3). mixed-powder obtained for step (2) is joined in the water of 5 times of weight, ultrasonic boil be heating to liquor capacity before solvent volume 1/5, elimination precipitates; Add the mannitol of solution weight 1/10, be stirred to dissolving;
(4). every bottle of 5ml fill and get final product.
The each component formula amount of < table 1, with parts by weight >
salidroside content measures embodiment
Carry out according to the mensuration of rhodioloside " in the health food " first method in " health food inspection and assessment technical specification ".
Rhodioloside standard solution: accurately take rhodioloside standard substance 0.02g, add and dissolve and be settled to 10ml.
Sample pretreating: take the obtained each 20ml of sample of embodiment 1 ~ 5 respectively in 50ml measuring bottle, first add 25ml methanol, after ultrasonic 10min by methanol constant volume to scale, mixing, then through 0.45 μm of membrane filtration, be need testing solution.
Chromatographic condition: chromatographic column is C18 post, 4.6 × 250 × 5 μm; Column temperature is room temperature; Determined wavelength 215nm; Mobile phase is methanol: 0.02mol/l sodium acetate solution=9:91; Flow velocity is 1.0ml/min.
Specification Curve of Increasing: configuration concentration is 0,0.01,0.02,0.05,0.2,0.5 μ g/ml rhodioloside standard solution respectively, analyzes, do standard curve with peak area to concentration under above-mentioned given chromatographic condition.
Test process: get 10 μ l standard solution and need testing solution injection liquid chromatography, qualitative with retention time, with sample peak area and standard comparing quantitative.
Computing formula: X=(A
1× C × V)/(A
2× m × 1000), wherein: X is the content of rhodioloside in sample, mg/g; A
1for test sample peak area; C is concentration of standard solution, μ g/ml; V is sample constant volume, ml; A
2for standard solution peak area; M is sample mass, g.Result is as table 2:
< shows 2>
effect example
1. on the impact of mouse immune organ.
Get the male KM mice 140 that body weight is 12 ~ 15g, be divided into embodiment 1 ~ 5 group, commercially available product group and blank group totally 7 groups at random by body weight.Often organize 20 mices.Every day gastric infusion once, matched group gavage to the distilled water of same volume, continuous 7 days.Last administration is after 24 hours, puts to death animal, weigh and thymus, spleen weight, using the ratio of thymus or spleen weight (mg) and body weight (g) as thymus or Spleen coefficient.Result is as table 3:
< shows 3>
* be contrast with commercially available product group, p<0.05;
#for contrasting with matched group, p<0.05
2. D-galactose is damaged to the impact of mice lipofuscin content and anti-oxidation function enzyme activity
Select three monthly ages healthy Kunming mouse male and female half and half totally 80,18-20g.Be divided into 8 groups at random: normal group, model group, commercially available product group, embodiment 1 ~ 5 group.Adopt single cage to raise, freely ingest and drinking-water, room temperature 18-20 DEG C, daylight lamp floor light, maintain illumination every day 12 hours.
With the 0.96%D-galactose of normal saline, 5mg/kg body weight, subcutaneous injection modeling, every day 1 time, continuous modeling 6 weeks, normal group not modeling.Dosing group per os gives different given the test agent, model group and normal group give same volume solvent, while giving given the test agent, except normal group, each group is continued to give same dose D-galactose subcutaneous injection, normal group subcutaneous injection normal saline, experiment terminates to put to death animal, surveys lipofuscin content and anti-oxidation function enzyme activity.Measurement result carries out statistical disposition, the results are shown in Table 4:
< shows 4>
* be contrast with commercially available product group, p<0.05;
#for contrasting with model group, p<0.05
The present invention is not limited to above-mentioned embodiment, if do not depart from the spirit and scope of the present invention to various change of the present invention or distortion, if these are changed and distortion belongs within claim of the present invention and equivalent technologies scope, then the present invention is also intended to comprise these changes and distortion.
Claims (6)
1. an anti-apolexis composition, is characterized in that being made up of the component of following weight portion: Margarita powder 10 ~ 30 parts, Semen Armeniacae Amarum powder 30 ~ 50 parts, the Radix Paeoniae Alba 5 ~ 15 parts, Rhizoma Polygonati Odorati 5 ~ 15 parts, Radix Angelicae Sinensis 10 ~ 20 parts, 30 ~ 50 parts, Radix Glycyrrhizae, Radix Ophiopogonis 5 ~ 15 parts, 30 ~ 50 parts, Semen Persicae, Rhizoma Chuanxiong 5 ~ 15 parts, Radix Angelicae Pubescentis 10 ~ 20 parts, Semen Coicis 10 ~ 20 parts, Radix Saposhnikoviae 10 ~ 20 parts, Radix Codonopsis 5 ~ 15 parts, 10 ~ 20 parts, Testa oryzae, Radix Scutellariae 10 ~ 20 parts, Radix Rhodiolae 1 ~ 5 part, Folium Ginkgo 5 ~ 15 parts.
2. a kind of anti-apolexis composition according to claim 1, is characterized in that being made up of the component of following weight portion: Margarita powder 15 ~ 25 parts, Semen Armeniacae Amarum powder 35 ~ 45 parts, the Radix Paeoniae Alba 8 ~ 12 parts, Rhizoma Polygonati Odorati 8 ~ 12 parts, Radix Angelicae Sinensis 12 ~ 17 parts, 35 ~ 45 parts, Radix Glycyrrhizae, Radix Ophiopogonis 8 ~ 13 parts, 35 ~ 45 parts, Semen Persicae, Rhizoma Chuanxiong 9 ~ 12 parts, Radix Angelicae Pubescentis 13 ~ 18 parts, Semen Coicis 12 ~ 17 parts, Radix Saposhnikoviae 12 ~ 18 parts, Radix Codonopsis 8 ~ 13 parts, 12 ~ 18 parts, Testa oryzae, Radix Scutellariae 12 ~ 18 parts, Radix Rhodiolae 2 ~ 4 parts, Folium Ginkgo 8 ~ 13 parts.
3. a kind of anti-apolexis composition according to claim 2, is characterized in that being made up of the component of following weight portion: Margarita powder 20 parts, Semen Armeniacae Amarum powder 40 parts, the Radix Paeoniae Alba 10 parts, Rhizoma Polygonati Odorati 10 parts, Radix Angelicae Sinensis 15 parts, 40 parts, Radix Glycyrrhizae, Radix Ophiopogonis 10 parts, 40 parts, Semen Persicae, Rhizoma Chuanxiong 10 parts, Radix Angelicae Pubescentis 15 parts, Semen Coicis 15 parts, Radix Saposhnikoviae 15 parts, Radix Codonopsis 10 parts, 15 parts, Testa oryzae, Radix Scutellariae 15 parts, Radix Rhodiolae 3 parts, Folium Ginkgo 10 parts.
4. prepare a method for a kind of anti-apolexis composition as described in claims 1 to 3 any one, it is characterized in that comprising the following steps:
(1). by formula ratio, the Radix Paeoniae Alba, Rhizoma Polygonati Odorati, Radix Angelicae Sinensis, Radix Glycyrrhizae, Radix Ophiopogonis, Semen Persicae, Rhizoma Chuanxiong, Radix Angelicae Pubescentis, Semen Coicis, Radix Saposhnikoviae, Radix Codonopsis, Testa oryzae, Radix Scutellariae, Radix Rhodiolae and Folium Ginkgo are shone dry grinding;
(2). add Margarita powder, Semen Armeniacae Amarum powder, mix homogeneously;
(3). mixed-powder obtained for step (2) is joined in the water of 5 times of weight, ultrasonic boil be heating to liquor capacity before solvent volume 1/5, elimination precipitates; Add the mannitol of solution weight 1/10, be stirred to dissolving;
(4). every bottle of 5ml fill and get final product.
5. a kind of anti-apolexis composition according to claim 5, is characterized in that: the Radix Paeoniae Alba after described pulverizing, Rhizoma Polygonati Odorati, Radix Angelicae Sinensis, Radix Glycyrrhizae, Radix Ophiopogonis, Semen Persicae, Rhizoma Chuanxiong, Radix Angelicae Pubescentis, Semen Coicis, Radix Saposhnikoviae, Radix Codonopsis, Testa oryzae, Radix Scutellariae, Radix Rhodiolae, Folium Ginkgo mixed-powder and Margarita powder and Semen Armeniacae Amarum powder are by 200 mesh sieves.
6. the purposes of anti-apolexis composition described in claims 1 to 3 any one in the antidotal external use skin care of preparation or medicine.
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Citations (4)
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| CN1279073A (en) * | 2000-04-17 | 2001-01-10 | 李熙德 | Antisenility Chinese medicine |
| CN101745034A (en) * | 2008-12-10 | 2010-06-23 | 高莹 | Anti-ageing life-prolonging medicine |
| CN102178301A (en) * | 2011-04-21 | 2011-09-14 | 深圳市唤然生物科技开发有限公司 | Blueberry health care beverage and preparation method thereof |
| CN103316208A (en) * | 2013-06-17 | 2013-09-25 | 邓占峰 | Traditional Chinese medicine preparation with functions of benefiting qi and nourishing blood, resisting aging and prolonging life |
-
2015
- 2015-11-24 CN CN201510824678.6A patent/CN105288596A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1279073A (en) * | 2000-04-17 | 2001-01-10 | 李熙德 | Antisenility Chinese medicine |
| CN101745034A (en) * | 2008-12-10 | 2010-06-23 | 高莹 | Anti-ageing life-prolonging medicine |
| CN102178301A (en) * | 2011-04-21 | 2011-09-14 | 深圳市唤然生物科技开发有限公司 | Blueberry health care beverage and preparation method thereof |
| CN103316208A (en) * | 2013-06-17 | 2013-09-25 | 邓占峰 | Traditional Chinese medicine preparation with functions of benefiting qi and nourishing blood, resisting aging and prolonging life |
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