CN103735937A - Drug and health product capable of promoting iron component absorption and enriching blood - Google Patents

Drug and health product capable of promoting iron component absorption and enriching blood Download PDF

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CN103735937A
CN103735937A CN201310504274.XA CN201310504274A CN103735937A CN 103735937 A CN103735937 A CN 103735937A CN 201310504274 A CN201310504274 A CN 201310504274A CN 103735937 A CN103735937 A CN 103735937A
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radix
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CN103735937B (en
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孙霞
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Kaiputai (Beijing) Medical Technology Co Ltd
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Qingdao Huaren Technology Incubator Co Ltd
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Abstract

The invention provides a traditional Chinese medicine composition health product capable of promoting iron component absorption and enriching blood. A traditional Chinese medicine composition comprises the raw medicinal materials: American ginseng, atractylodes macrocephala, Chinese date, prepared rehmannia root, arillus longan, radix bupleuri, fructus lycii, radix polygoni multiflori, angelicae sinensis radix, radix paeoniae alba, cortex acanthopanacis, China rose, cistanche, erigeron breviscapus, rhodiola rosea, root of szechwan-yunnan sanicle, malt, gorgon fruit, colla corii asini, lysimachia insignis hemsl, Chinese holly leaf, cynomorium songaricum and black sesame. The traditional Chinese medicine composition provided by the invention can more effectively promote a body to absorb iron, can be used for prevention and treatment of iron-deficiency anemia in daily life, has good taste, and does not stimulate stomach and intestines.

Description

There are the medicine and the health product that promote that ferrous components absorbs and enriches blood
Technical field
The present invention relates to health product technology field, relate in particular to a kind of for preventing and treat medicine and the health product that promote that ferrous components absorbs and enriches blood that have of iron deficiency anemia.
Background technology
Iron deficiency anemia, is a kind of trace element deficiency that sickness rate is the highest, is a kind of common food deficiency disease, and whole world anemia patient surpasses 2,000,000,000, and wherein 50% belongs to iron deficiency anemia, and the average prevalence of anemia of China resident reaches 20.1%.Be generally considered to be among the crowd of " normal person ", approximately having 11% people in iron deficiency anemia state, especially in child and adolescent girls, this has become a very clinical treatment problem for significant.
Anemia not only shows as the symptoms such as palor, shortness of breath and palpitation, and also, usually with the decline of muscle power, endurance and study, work capacity, lassitude and weak is one of anemia symptom the most common and that occur the earliest.
Iron deficiency anemia because storing iron deficiency in body, affect that haemachrome is synthetic to be caused, be characterized in that bone marrow, liver, spleen lack stainability ferrum, cause that the reason of iron deficiency mainly contains: the requirement of ferrum increases and the malabsorption of Deficiency of Intake, ferrum or lose blood etc.In adult, chronic a small amount of hemorrhage be also to cause the modal reason of iron deficiency anemia.
In order to improve iron deficiency anemia, current western medicine is mainly to adopt iron supplement agent, adopt the object of iron in treatment iron deficiency anemia to have two, one is to provide the needed ferrum element of synthetic hemoglobin, reverse the pathophysiological change that iron deficiency loss itself and anemia cause, improve the symptom of anemia, the 2nd, supplement body Chu Tie pond (as bone marrow, spleen etc.) storage iron in, thereby fundamentally improve the ferrum nutriture of body, make body be unlikely to again to affect hemoglobin in the situation that of short-term or slight ferrum imbalance of supply and demand synthetic, cause anemia, adopt iron in treatment, clinical efficacy is rapid, but easily cause the untoward reaction of gastrointestinal tract etc., cause diarrhoea, the generation of the symptoms such as vomiting, because body exists larger individual variation to the absorption of ferrum and metabolism, the needed time phase difference of therapeutic purposes that different patients are reached is very large, the course for the treatment of is not enough, anemia can not be improved or store ferrum and be can not get supplying, the course for the treatment of process, can cause the interior excessive accumulation of body of ferrum, body is produced to a series of harmful effect.
In general, ferrous iron is more conducive to absorption of human body compared with ferric iron.Although have various iron supplement food and preparation on market now, in fact, the iron supplement effect of these products is unsatisfactory.This may be that the approach of taking in due to ferrum is very incorrect on the one hand, such as oral ferrous sulfate tablet, although the ferrous sulfate amount of taking is larger, body does not have ability to absorb so large amount, so most of ferrum has been depleted again, only has small part to be absorbed by body and bring into play physiological function; May be not to be fully utilized because iron fortified food product enters in human body on the other hand, bioavailability depends on the chemical form of element itself and the content in food, may due to dosage form or preservation improper, ferrous iron in quite a few iron preparation has been oxidized to ferric iron before entering human body, has lost the value that body utilizes; In addition, even if human body has been taken in enough ferrum, if but be not fully absorbed and play a role, or because causing the absorption of ferrum element, the interaction between various nutrients suppresses, it is not fully used, still can not alleviates sideropenic present situation, therefore, also need to develop high iron fortified food product or the preparation that sends more effective high bioavailability, in order to prevent and treat iron deficiency anemia.
The traditional Chinese medical science is thought, the category of anemia genus " syndrome of deficiency of blood ", by the principle of " weakened configuration person; warming with drugs of thick nature; insufficiency of essence person, tonifying with drugs of thick flavor ", tonifying for deficiency syndrome, train it basic, invigorating the spleen and regulating the stomach, strengthens self resistance against diseases, and short its absorbs and hemopoietic function, deficiency syndrome should be treated by tonifying method, this disease is mainly that the reasons such as eating and drinking without temperance, innate deficiency, obstinate disease, infection parasites are caused.Blood stored in the liver, have storage blood, regulate blood volume, prevent hemorrhage function, liver master dredges rushes down, can regulate mechanism of qi, help transporting and transforming function of the spleen and stomach, taste the foundation of acquired constitution, source of generating QI and blood, system blood dirty, liver and regulating qi, the fluent taste of mechanism of qi hemopoietic liquid is normal, QI and blood is raw, and QI and blood row is in body, more bad in the catharsis effect of liver, blood stored in the liver and the spleen governs the blood complement each other, and jointly prevent outside blood oozing from the body openings or subcuta neous tissue arteries and veins qi promoting blood production, therefore enrich blood, need take into account QI invigorating, QI and blood is with mending, and spleen invigorating helps fortune.In the side's of enriching blood medicine, compatibility QI invigorating medicine, can receive the effect of qi-supplementing, blood-engendering, Chinese medicine preparation is better than Oral Iron Preparations improving aspect symptom, and gastrointestinal function is improved to effect, is difficult for recurrence after drug withdrawal, this points out us to utilize tcm syndrome differentiation and treatment, bring into play the characteristic of the traditional Chinese medical science to improve clinical efficacy, and can bring into play the advantage of traditional Chinese medical science preventive treatment of disease.
Summary of the invention
Technical problem to be solved by this invention is to provide that a kind of it can more effectively promote the absorption of body to ferrum, can be used for preventing and treating in daily life iron deficiency anemia for preventing and treating the health product of iron deficiency anemia, and mouthfeel is good, non-stimulated to gastrointestinal.
For solving the problems of the technologies described above, the invention provides a kind of Chinese medicine composition that promotes that ferrous components absorbs and enriches blood that has, its crude drug comprises Radix Panacis Quinquefolii, the Rhizoma Atractylodis Macrocephalae, Fructus Jujubae, Radix Rehmanniae Preparata, Arillus Longan, Radix Bupleuri, Fructus Lycii, Radix Polygoni Multiflori, Radix Angelicae Sinensis, the Radix Paeoniae Alba, Cortex Acanthopancis, Flos Rosae Chinensis, Herba Cistanches, Herba Erigerontis, Radix Rhodiolae, Radix Saniculae Astrantifoliae, Fructus Hordei Germinatus, Semen Euryales, Colla Corii Asini, Herba Lysimachiae Insignis, Folium Mahoniae, Herba Cynomorii and Semen Sesami Nigrum.
Wherein, in described Chinese medicine composition, the weight of each raw material is respectively Radix Panacis Quinquefolii 45 weight portion～55 weight portions, the Rhizoma Atractylodis Macrocephalae 30 weight portion～40 weight portions, Fructus Jujubae 60 weight portion～70 weight portions, Radix Rehmanniae Preparata 80 weight portion～90 weight portions, Arillus Longan 35 weight portion～45 weight portions, Radix Bupleuri 30 weight portion～40 weight portions, Fructus Lycii 50 weight portion～60 weight portions, Radix Polygoni Multiflori 80 weight portion～90 weight portions, Radix Angelicae Sinensis 60 weight portion～70 weight portions, the Radix Paeoniae Alba 50 weight portion～60 weight portions, Cortex Acanthopancis 35 weight portion～45 weight portions, Flos Rosae Chinensis 20 weight portion～30 weight portions, Herba Cistanches 55 weight portion～65 weight portions, Herba Erigerontis 15 weight portion～25 weight portions, Radix Rhodiolae 20 weight portion～30 weight portions, Radix Saniculae Astrantifoliae 30 weight portion～40 weight portions, Fructus Hordei Germinatus 55 weight portion～65 weight portions, Semen Euryales 45 weight portion～55 weight portions, Colla Corii Asini 110 weight portion～120 weight portions, Herba Lysimachiae Insignis 35 weight portion～45 weight portions, Folium Mahoniae 20 weight portion～30 weight portions, Herba Cynomorii 20 weight portion～30 weight portions and Semen Sesami Nigrum 50 weight portion～60 weight portions.
Wherein, in described Chinese medicine composition, the weight portion of each raw material is Radix Panacis Quinquefolii 50 weight portions, the Rhizoma Atractylodis Macrocephalae 35 weight portions, Fructus Jujubae 65 weight portions, Radix Rehmanniae Preparata 85 weight portions, Arillus Longan 40 weight portions, Radix Bupleuri 35 weight portions, Fructus Lycii 55 weight portions, Radix Polygoni Multiflori 85 weight portions, Radix Angelicae Sinensis 65 weight portions, the Radix Paeoniae Alba 55 weight portions, Cortex Acanthopancis 40 weight portions, Flos Rosae Chinensis 25 weight portions, Herba Cistanches 60 weight portions, Herba Erigerontis 20 weight portions, Radix Rhodiolae 25 weight portions, Radix Saniculae Astrantifoliae 35 weight portions, Fructus Hordei Germinatus 60 weight portions, Semen Euryales 50 weight portions, Colla Corii Asini 115 weight portions, Herba Lysimachiae Insignis 40 weight portions, Folium Mahoniae 25 weight portions, Herba Cynomorii 25 weight portions and Semen Sesami Nigrum 55 weight portions.
The present invention also provides the preparation method of above-mentioned Chinese medicine composition, is specially:
The first step, the extraction of above-mentioned traditional Chinese medicinal composition raw materials;
Second step, the purification of extract.
Wherein, the described first step is specially mixes each raw material medicaments in part by weight in described Chinese medicine, stir, add the water with respect to 6～8 times of mixture qualities, it is 2～3 that the hydrochloric acid that is 5% by volumetric concentration regulates the pH value of water, soak 1 hour～2 hours, decoct subsequently 3 hours～5 hours, decoction liquor is filtered, filtering residue adds the water with respect to 4～6 times of mixture qualities again, decoct 3 hours～5 hours, decoction liquor is filtered, decoction liquor is merged, by mass percentage concentration, be that 10% sodium hydroxide regulates pH value to 6～7, obtain extracting solution, the mastic that at 50 ℃ of extracting solution simmer down tos, relative density is 1.10～1.20, be cooled to room temperature, adding concentration is that 95% ethanol to alcohol content reaches 60%, 0 ℃ of cold preservation 12 hours, filter, filtrate decompression concentration and recovery ethanol, be concentrated into the mastic that at 50 ℃, relative density is 1.10～1.20.
Wherein, described second step is specially the thick paste that the first step is obtained and adds on the macroporous adsorptive resins of D101 type, first adopt the water of 1～2 times of column volume to rinse, adopting 3～5 times of ethanol elutions that column volume determining alcohol is 30%, adopt again the ethanol elution that 3～5 times of column volume determining alcohols are 70%, the ethanol elution that the ethanol elution that collection determining alcohol is 30% and determining alcohol are 70%, being evaporated to relative density at 50 ℃ is 1.10～1.20, add isopyknic water, 0 ℃ of cold preservation 12 hours, filter, filtrate is concentrated except desolventizing, pulverize, dry, obtain Chinese medicine composition and extract purified.
The present invention also provides a kind of blood-enriching oral liquid, and it comprises above-mentioned Chinese medicine composition, vitamin C, vitamin B 2, brown sugar, the water of iron supplement agent and She's amount.
Wherein, in described blood-enriching oral liquid, the percentage by weight of each component is respectively described Chinese medicine composition 30%～40%, vitamin C 3%～5%, vitamin B 23%～5%, brown sugar 10%～18%, the water of iron supplement agent 8%～12% and She's amount.
Wherein, in described blood-enriching oral liquid health product, the percentage by weight of each component is described Chinese medicine composition 35%, vitamin C 4%, vitamin B 24%, brown sugar 15%, the water of iron supplement agent 10% and She's amount.
The present invention also provides the preparation method of this blood-enriching oral liquid, is specially:
The first step, prepares Chinese medicine composition according to the method described above;
Second step, it is 10% soda bath that 25g dissolution of sodium hydroxide is prepared into mass percentage concentration in distilled water, slowly adds subsequently 50g ferrous porphyrin, is stirred to completely and dissolves, and obtains solution;
The 3rd step, by 75g brown sugar, 20g vitamin C, 20g vitamin B 2the Chinese medicine composition of preparing with the 175g first step slowly adds in the solution of second step acquisition, stirs completely, and pH regulated value 6～8,0 ℃ of cold preservation 12 hours, filter, with distilled water diluting to 500ml, 60～80 ℃ of hot embeddings, 121 ℃ of autoclavings, lamp inspection, check, packing.
Beneficial effect of the present invention:
Chinese medicine composition provided by the invention and blood-enriching oral liquid health product can more effectively promote the absorption of body to ferrum, can be used for preventing and treating in daily life iron deficiency anemia, and mouthfeel is good, non-stimulated to gastrointestinal.
The specific embodiment
The traditional Chinese medical science is thought, the category of anemia genus " syndrome of deficiency of blood ".Deficiency syndrome should be treated by tonifying method, this disease is mainly that the reasons such as eating and drinking without temperance, innate deficiency, obstinate disease, infection parasites are caused.
The root of kidney asthenia as the principal aspect disease, kidney storing essence, the raw marrow of main bone, essence can be changed blood, marrow energy hemopoietic, essence and blood sharing the same origin, suffers from a deficiency of the kidney that essence and blood source is not enough, and temper depends on the warm of yang-energy of kidney can the precise and tiny blood that is changed to of normal metaplastic, and the marrow virtual loss of suffering from a deficiency of the kidney blood must be empty few.Kidney is that whole body vigour is basic, kidney storing essence, and raw marrow, main bone, therefore kidney essense is abundant, can changes and be blood.Modern study thinks that traditional Chinese medical science invigorating kidney, promoting blood circulation can regulate body's immunity, stimulates hemopoietic function of bone marrow, improves bone marrow microenvironment, make hemoglobin reduction no matter the removal of the cause of disease still regenerate and recover all to play an important role.Modern medicine is thought the organ that bone marrow, liver, spleen etc. are storage ferrum, and ferrum is the main component of synthetic hemoglobin, thinks kidney controlling essence storage with the traditional Chinese medical science, the raw marrow of main bone, and marrow hemopoietic has points of resemblance.
Taste are the key of primary disease, and spleen and kidney are the relation of " day after tomorrow " and " congenital ", are mutual promotions, mutually promote, on pathology, also influence each other, and reciprocal causation.Insufficiency of kidney-YANG can not be warm spleen sun; A little less than deficiency of spleen-YANG, the precise and tiny kidney yang of inability of food and drink to be digested and transported is lost it and is supplemented nutrition." qi being the governor of blood, blood being the material foundation of QI ", gas and blood have contact closely between the two.Qi promoting blood production, refers in the composition and generative process thereof of blood, all be unable to do without gentle motion change one gasification function of gas.Ying-qi and body fluid, be the key component of blood, and they are from the essence of water and grain of taste institute transporting.From the ingesta of taking in, change into essence of water and grain, then change into ying-qi and body fluid, then change into blood, all be unable to do without the motion change of gas.Spleen invigorating can supplement the deficiency of taste, for QI and blood biochemistry provides home, and the QI invigorating hemopoietic of can invigorating blood circulation.The generation of blood and the relation of spleen are the closest." blood person essence of water and grain is born in spleen ", " spleen is source of generating QI and blood ".Taste are received digesting food, produce cereal nutrient, and for the generation of blood provides Material Source, the raw function of change of spleen is the power that blood generates.Temper also has the function of having the normal operation of blood under one's command.The many reasons such as eating and drinking without temperance, overstrain, weakness due to chronic disease all can undermine spleen and stomach function, cause water paddy and are received deficiency, cause the weary source of cereal nutrient, or occur the raw miopragia of spleenization, the precise and tiny obstacle that utilizes, thus cause primary disease to occur.Deficiency-weakness of spleen-QI, has dereliction of duty under one's command, and outside blood oozing from the body openings or subcuta neous tissue arteries and veins, Massive Bleeding (acute or chronic) also can cause primary disease.
" qi being the governor of blood, blood being the material foundation of QI ", gas and blood have contact closely between the two.Qi promoting blood production, refers in the composition and generative process thereof of blood, all be unable to do without gentle motion change one gasification function of gas.Ying-qi and body fluid, be the key component of blood, and they are from the essence of water and grain of taste institute transporting.From the ingesta of taking in, change into essence of water and grain, then change into ying-qi and body fluid, then change into blood, all be unable to do without the motion change of gas.Therefore say qi promoting blood production.Gas is prosperous, and the function of changing hemopoietic liquid is also strong; The deficiency of vital energy, the function of changing hemopoietic liquid also a little less than, very can cause blood deficiency.
Blood stored in the liver, have storage blood, regulate blood volume, prevent hemorrhage function, liver master dredges rushes down, can regulate mechanism of qi, help transporting and transforming function of the spleen and stomach, taste the foundation of acquired constitution, source of generating QI and blood, system blood dirty, liver and regulating qi, the fluent taste of mechanism of qi hemopoietic liquid is normal, QI and blood is raw, and QI and blood row is in body, more bad in the catharsis effect of liver, blood stored in the liver and the spleen governs the blood complement each other, and jointly prevent outside blood oozing from the body openings or subcuta neous tissue arteries and veins qi promoting blood production, therefore enrich blood, need take into account QI invigorating, QI and blood is with mending, and spleen invigorating helps fortune.In the side's of enriching blood medicine, compatibility QI invigorating medicine, can receive the effect of qi-supplementing, blood-engendering.
Theoretical based on above-mentioned Chinese traditional treatment, the present invention proposes with invigorating the spleen and benefiting QI, promoting blood flow to regulate menstruation, soothing the liver enriching blood as principle, provide a kind of for preventing and treat the Chinese medicine composition that promotes that ferrous components absorbs and enriches blood that has of iron deficiency anemia, its crude drug comprises Radix Panacis Quinquefolii, the Rhizoma Atractylodis Macrocephalae, Fructus Jujubae, Radix Rehmanniae Preparata, Arillus Longan, Radix Bupleuri, Fructus Lycii, Radix Polygoni Multiflori, Radix Angelicae Sinensis, the Radix Paeoniae Alba, Cortex Acanthopancis, Flos Rosae Chinensis, Herba Cistanches, Herba Erigerontis, Radix Rhodiolae, Radix Saniculae Astrantifoliae, Fructus Hordei Germinatus, Semen Euryales, Colla Corii Asini, Herba Lysimachiae Insignis, Folium Mahoniae, Herba Cynomorii and Semen Sesami Nigrum.
In side, Radix Panacis Quinquefolii is containing the total soap two of Radix Ginseng, the total soap two of Radix Ginseng in vivo and in vitro all can hemopoietic stem cell and the propagation of hemopoietic progenitor cell, the effect with similar hemopoietic growth factor, the Rhizoma Atractylodis Macrocephalae can increase the secretion of digestive system, hemopoietic system, rising erythrocyte and hemoglobin, improve lymhocyte transformation rate, Arillus Longan the kidney invigorating and essence nourishing, benefiting QI and nourishing blood, Radix Rehmanniae Preparata can hemopoietic system, rising erythrocyte, Fructus Jujubae contains vitamin C, ferrum etc., can increase gastric enzyme, promote the absorption of ferrum, Radix Polygoni Multiflori can the hemopoietic factor be secreted, can promote the synthetic of erythrocytic growth promoter and hemoglobin, the gas reason of waking up spleen, Radix Bupleuri depressed liver-energy dispersing and QI regulating, Fructus Lycii nourishing the liver and kidney, control blood deficiency and yellow complexion, with Radix Polygoni Multiflori, Radix Angelicae Sinensis compatibility can be subsidized essence and blood, YIN nourishing is with pig sample, Fructus Lycii can also immune stimulatory hemopoietic system, Radix Angelicae Sinensis is pungent sweet and warm, enrich blood and seek, contained vitamin B 12and folic acid can anti-anemia, that ferrum absorbs indispensable material, Radix Paeoniae Alba nourishing blood for regulating menstruation, for blood deficiency and yellow complexion, expelling wind and removing dampness, liver and kidney tonifying, Flos Rosae Chinensis promoting blood flow to regulate menstruation, dispersing the stagnated live-QI to relieve the stagnation of QI, Herba Cistanches kidney-replenishing, benefiting essence-blood, the pain relieving of Herba Erigerontis promoting blood circulation to restore menstrual flow, Radix Rhodiolae benefiting QI for activating blood circulation, promote blood circulation and relieving asthma, Fructus Hordei Germinatus promote qi circulation digestion promoting, spleen benefiting and stimulating the appetite, Semen Euryales supplementing the kidney to control the nocturnal, spleen reinforcing antidiarrheal, Colla Corii Asini nourishing blood YIN nourishing, moisturize hemostasis, Herba Lysimachiae Insignis dispelling wind and removing obstruction in the collateral, promoting flow of QI and blood, Radix Saniculae Astrantifoliae tonifying the lung and stopping cough, kidney tonifying nourishes heart, Folium Mahoniae liver and kidney tonifying, wind-damp dispelling, Herba Cynomorii kidney invigorating and YANG supporting, benefiting essence-blood, Semen Sesami Nigrum invigorating the liver and kidney, support essence and blood, all medicines share, spleen invigorating helps fortune, mediation gastrointestinal, qi-supplementing, blood-engendering, and the property of medicine is gentle, mouthfeel is suitable.
Further, described Chinese medicine composition only has above-mentioned raw materials medicine to form.
In described Chinese medicine composition, the weight of each raw material is respectively Radix Panacis Quinquefolii 45 weight portion～55 weight portions, the Rhizoma Atractylodis Macrocephalae 30 weight portion～40 weight portions, Fructus Jujubae 60 weight portion～70 weight portions, Radix Rehmanniae Preparata 80 weight portion～90 weight portions, Arillus Longan 35 weight portion～45 weight portions, Radix Bupleuri 30 weight portion～40 weight portions, Fructus Lycii 50 weight portion～60 weight portions, Radix Polygoni Multiflori 80 weight portion～90 weight portions, Radix Angelicae Sinensis 60 weight portion～70 weight portions, the Radix Paeoniae Alba 50 weight portion～60 weight portions, Cortex Acanthopancis 35 weight portion～45 weight portions, Flos Rosae Chinensis 20 weight portion～30 weight portions, Herba Cistanches 55 weight portion～65 weight portions, Herba Erigerontis 15 weight portion～25 weight portions, Radix Rhodiolae 20 weight portion～30 weight portions, Radix Saniculae Astrantifoliae 30 weight portion～40 weight portions, Fructus Hordei Germinatus 55 weight portion～65 weight portions, Semen Euryales 45 weight portion～55 weight portions, Colla Corii Asini 110 weight portion～120 weight portions, Herba Lysimachiae Insignis 35 weight portion～45 weight portions, Folium Mahoniae 20 weight portion～30 weight portions, Herba Cynomorii 20 weight portion～30 weight portions and Semen Sesami Nigrum 50 weight portion～60 weight portions.
Further, the weight portion of each raw material Radix Panacis Quinquefolii 50 weight portion～55 weight portions more preferably in described Chinese medicine composition, the Rhizoma Atractylodis Macrocephalae 35 weight portion～40 weight portions, Fructus Jujubae 65 weight portion～70 weight portions, Radix Rehmanniae Preparata 85 weight portion～90 weight portions, Arillus Longan 40 weight portion～45 weight portions, Radix Bupleuri 30 weight portion～35 weight portions, Fructus Lycii 55 weight portion～60 weight portions, Radix Polygoni Multiflori 85 weight portion～90 weight portions, Radix Angelicae Sinensis 65 weight portion～70 weight portions, the Radix Paeoniae Alba 55 weight portion～60 weight portions, Cortex Acanthopancis 35 weight portion～40 weight portions, Flos Rosae Chinensis 20 weight portion～25 weight portions, Herba Cistanches 60 weight portion～65 weight portions, Herba Erigerontis 15 weight portion～20 weight portions, Radix Rhodiolae 20 weight portion～25 weight portions, Radix Saniculae Astrantifoliae 30 weight portion～35 weight portions, Fructus Hordei Germinatus 55 weight portion～60 weight portions, Semen Euryales 45 weight portion～50 weight portions, Colla Corii Asini 115 weight portion～120 weight portions, Herba Lysimachiae Insignis 35 weight portion～40 weight portions, Folium Mahoniae 20 weight portion～25 weight portions, Herba Cynomorii 20 weight portion～25 weight portions and Semen Sesami Nigrum 55 weight portion～60 weight portions.
Further, the weight portion of each raw material Radix Panacis Quinquefolii 50 weight portions more preferably in described Chinese medicine composition, the Rhizoma Atractylodis Macrocephalae 35 weight portions, Fructus Jujubae 65 weight portions, Radix Rehmanniae Preparata 85 weight portions, Arillus Longan 40 weight portions, Radix Bupleuri 35 weight portions, Fructus Lycii 55 weight portions, Radix Polygoni Multiflori 85 weight portions, Radix Angelicae Sinensis 65 weight portions, the Radix Paeoniae Alba 55 weight portions, Cortex Acanthopancis 40 weight portions, Flos Rosae Chinensis 25 weight portions, Herba Cistanches 60 weight portions, Herba Erigerontis 20 weight portions, Radix Rhodiolae 25 weight portions, Radix Saniculae Astrantifoliae 35 weight portions, Fructus Hordei Germinatus 60 weight portions, Semen Euryales 50 weight portions, Colla Corii Asini 115 weight portions, Herba Lysimachiae Insignis 40 weight portions, Folium Mahoniae 25 weight portions, Herba Cynomorii 25 weight portions and Semen Sesami Nigrum 55 weight portions.
In described Chinese medicine composition, each raw material pharmacology is as follows:
Radix Panacis Quinquefolii: sweet in the mouth, micro-hardship, cool in nature, GUIXIN, lung, kidney channel, have boosting qi and nourishing yin, and the effect of clearing away heat and promoting production of body fluid cures mainly the deficiency of vital energy thanks to cloudy, interior-heat, cough with asthma expectorant blood, deficiency-heat is tired tired, quenches one's thirst, dryness of the mouth and throat.
The Rhizoma Atractylodis Macrocephalae: sweet in the mouth, hardship, warm in nature, enter spleen, stomach warp, there is spleen reinforcing promoting the circulation of QI, dampness diuretic, strengthening superficial resistance to stop perspiration, the effect that activating the spleen is moisturized, is mainly used in the feeling of fullness diarrhoea due to dysfunction of the spleen in transportation, QI failing to transform into body fluid, phlegm retention edema; The vexed lazy speech of deficiency of QI in middle-JIAO, metrorrhagia and metrostaxis, proctoptosis with chronic dysentery; The cards such as solid in the playing of deficiency of the spleen causing weakness of QI, sweating due to debility spontaneous perspiration.
Fructus Jujubae: sweet in the mouth, warm in nature, enter spleen, stomach warp, there is the effect of air making-up and spleen enlivening, nourishing blood to tranquillize the mind, harmonizing yingfen and weifen, the mitigation property of medicine, for weakness of the spleen and stomach, fatigue and asthenia, anorexia and loose stool, the card such as insufficiency of vital energy and blood, has a headache and fever, sweating hot blast.
Radix Rehmanniae Preparata: have another name called Radix Rehmanniae Preparata, sweet in the mouth, slightly warm in nature, enters liver, kidney channel, has the YIN nourishing of enriching blood, and beneficial essence is filled out the effect of marrow, for blood deficiency and yellow complexion; Dizzy, cardiopalmus, insomnia, menoxenia, collapses more than; Hepatic and renal YIN deficiency, night sweat, sufficient knee joint pain, soreness of the waist and knees, Hiccough and deaf, the head is dim-sighted; Seminal emission sexual impotence; Infertility; Menoxenia; Metrostaxis; Early whitening of beard and hair; Quench one's thirst; Constipation; The cards such as dyspnea with rapid and short breath of suffering from a deficiency of the kidney.
Arillus Longan: warm in nature, taste is sweet, has invigorating the heart and spleen, the effect of nourishing blood to tranquillize the mind, for cards such as insufficiency of vital energy and blood, severe palpitation, forgetful insomnia, blood deficiency and yellow complexion.
Radix Bupleuri: bitter in the mouth, cold nature, returns liver, gallbladder meridian, has to evacuate to bring down a fever, and the effect of yang invigorating soothing liver-QI, cures mainly cold, fever, alternate attack of chill and fever, malaria, stagnation of QI due to depression of the liver, sternal rib pain, proctoptosis, the card such as uterus comes off, menoxenia.
Fructus Lycii: sweet in the mouth, property are flat, enter liver, kidney channel, have liver and kidney tonifying, nourish blood enrich blood, the effect of replenishing vital essence to improve eyesight, nourishing the lung to arrest cough, be mainly used in soreness of the waist and knees, dizziness and tinnitus, seminal emission tinnitus, the unconsciously sweat and tire of Liver and kidney two void, asthenia of essence and blood; The sexual impotence of insufficiency of kidney-YANG, sterile; The cards such as the dim-sighted and deficiency of YIN chronic cough of the eyes of deficiency of YIN-essence, deficiency of liver-blood, Fructus Lycii can promote liver cell regeneration, the effect of enhancing non-specific immunity function.
Radix Polygoni Multiflori: bitter in the mouth, sweet, puckery, slightly warm in nature, returns liver, kidney channel, has the effect of nourishing the blood and yin, loosening bowel to relieve constipation, cures mainly blood deficiency Light-headedness; Cardiopalmus; Insomnia; The soreness of the waist and knees of the hepatic and renal YIN deficiency; Early whitening of beard and hair; Tinnitus; Seminal emission; Dryness of the intestine constipation; Chronic malaria body is empty; Rubella pruritus; Carbuncle sore; Scrofula; The cards such as hemorrhoid, Radix Polygoni Multiflori can make telangiectasis.
Radix Angelicae Sinensis: latin name Angelicae Sinensis Radix, sweet in the mouth, pungent, warm in nature, enter liver, the heart, spleen channel, having enriches blood invigorates blood circulation, menstruction regulating and pain relieving, the effect of loosening bowel to relieve constipation, cures mainly having a dizzy spell of deficiency of heart-blood, fatigue and weakness, shortness of breath and palpitation, the sea of blood is hollow, the menoxenia of the cold and deficiency of CHONG and REN meridians or congestion retardance, dysmenorrhoea, produce or stomachache, and other blood stasis is had a pain and the cards such as constipation of deficiency of YIN insufficiency of blood dryness of the intestine, its can improve uterus blood circulation, alleviate pelvic congestion, relieving dysmenorrhea.
The Radix Paeoniae Alba: bitter in the mouth, acid, cold nature, enters liver, spleen channel, the joint venture of nourishing blood, easing the affected liver to relieve pain, the effect of suppressing liver-YANG, is mainly used in headache feeling of fullness in the head, vertigo and tinnitus, the irritated irritability of deficiecny of liver-YIN, excessive rising of liver-YANG; Deficiency of liver-blood, battalion defends the menoxenia of inanition, metrorrhagia and metrostaxis; The dysmenorrhea of deficiency of the liver stasis dampness; Disharmony of nutrient QI with defensive QI, the cloudy outer inducing vomiting spontaneous sweating of battalion; The gastral cavity abdomen pain over the hypochondriac region of depression of liver-QI, dysentery stomachache; Deficiency and exhaustion of liver-YIN, passages through which vital energy circulates loses the cards such as carpopedal spasm pain of supporting, there is antithrombotic to form and hepatoprotective effect, dysentery bacterium, Bacillus typhi, blood dissolubility streptococcus, Diplococcus pneumoniae, bacillus pyocyaneus, staphylococcus aureus are had to inhibitory action, the Radix Paeoniae Alba and Radix Rehmanniae Preparata share, with nourishing YIN and benefiting blood, enrich blood, treat the dizzy card that waits of blood deficiency.
Cortex Acanthopancis: acrid in the mouth, hardship, warm in nature, return liver, kidney channel, there is wind-damp dispelling, invigorating the liver and kidney, bone and muscle strengthening, the effect of the arteries and veins of invigorating blood circulation, for anemofrigid-damp arthralgia; Lumbocrural pain; Muscles and bones flaccidity is soft; Children's's walking retardation in children; Body void is frail; Traumatic injury; Fracture; Edema; Foot gas; The uncontrolled urination card such as itch.
Flos Rosae Chinensis: latin name Rosae Chinensis Flos, sweet in the mouth, warm in nature, return Liver Channel, there is promoting blood flow to regulate menstruation, the effect of dispersing the stagnated live-QI to relieve the stagnation of QI, cures mainly qi depression to blood stasis, menoxenia, dysmenorrhea, amenorrhea, the cards such as distending pain in the chest and hypochondrium.
Herba Cistanches: sweet in the mouth, salty, warm in nature, enter kidney, large intestine channel, has kidney-replenishing, benefiting essence-blood, the effect of loosening bowel to relieve constipation, for kidney yang deficiency, the impotence and premature ejaculation of asthenia of essence and blood, sterility and infertility, soreness of waist and knee joint, Hiccough and deaf, frequent micturition urine number, suffer from a deficiency of the kidney dryness of the intestine and puerperal blood deficiency, the cards such as constipation of deficiency of body fluid after being ill.
Herba Erigerontis: acrid in the mouth, micro-hardship, warm in nature, there is expelling cold and relieving exterior syndrome, expelling wind and removing dampness, the effect of activating collaterals to relieve pain, for headache due to common cold, toothache, stomachache, rheumatalgia, the paralysis that cerebrovascular accident causes, the cards such as osteomyelitis.
Radix Rhodiolae: sweet, hardship, flat.Return lung, heart channel, there is benefiting QI for activating blood circulation, the effect of promoting blood circulation and relievining asthma, for blood stasis due to qi deficiency, obstruction of qi in the chest and cardialgia, apoplectic hemiplegia, the cards such as asthenia asthma, Radix Rhodiolae can improve the content of protein in Carnis Gallus domesticus.
Radix Saniculae Astrantifoliae: sweet in the mouth, micro-hardship, property is flat, has tonifying the lung and stopping cough, and the effect that kidney tonifying nourishes heart cures mainly phthisical cough, void is coughed, lumbago due to renal deficiency, giddy, the cards such as cardiopalmus.
Fructus Hordei Germinatus: sweet in the mouth, property is flat, returns spleen, stomach warp, have promote qi circulation digestion promoting, spleen benefiting and stimulating the appetite, moves back the effect of newborn relieving distension, curing mainly food stagnation does not disappear, abdominal distention is had loose bowels, nausea and vomiting, inappetence, milk smoulders, the cards such as distending pain of the breast, contain digestive enzyme and vitamin B group in Fructus Hordei Germinatus, gastric acid and pepsic secretion are had to facilitation.
Semen Euryales: sweet in the mouth, puckery, property is flat.Return spleen, kidney channel.There is supplementing the kidney to control the nocturnal, spleen reinforcing antidiarrheal, the function of damp eliminating leukorrhagia stopping, cures mainly emission, diarrhea due to hypofunction of the spleen, insufficiency of the spleen nebulousurine, is with inferior card.
Colla Corii Asini: sweet in the mouth, property are flat, enter lung, liver, kidney channel, have tonifying blood and arresting bleeding, nourshing Yin and drynsessmoistening prescription effect, can be used for the shallow complexion of various asthenia symptom, especially blood deficiency, and thin and weak weak, the head is dizzy, palpitation and insomnia; Malnutritional anemia, thrombocytopenic purpura; Deficient property hemoptysis; Haematemesis hematuria is had blood in stool; The cough dry pharynx of lung-dryness syndrome due to deficiency of YIN, sputum mixed with blood; The symptoms such as the spasm of muscles and vessels of pathogenic heat lingering, deficiency of YIN blood consumption, stirring-up of pathogenic wind in the interior resulting from deficiency, tetany, Colla Corii Asini has the erythrocytic generation of promotion, increases blood calcium concentration, promotes the effect of hemostasis, and contributes to strengthen the immunologic function of human body.
Herba Lysimachiae Insignis: acrid in the mouth, hardship, warm in nature, GUIXIN, lung meridian, have dispelling wind and removing obstruction in the collateral, and the effect of promoting flow of QI and blood, cures mainly rheumatic arthralgia, epigastric pain, treating swelling and pain by traumatic injury, the cards such as cough due to consumptive disease.
Folium Mahoniae: bitter in the mouth, cool in nature, return liver, kidney channel, there is clearind deficient heat, liver and kidney tonifying, the effect of wind-damp dispelling, cures mainly hectic fever due to deficiency of YIN, and cough hemoptysis, has a dizzy spell, soreness of the waist and knees, the cards such as rheumatic arthralgia.
Herba Cynomorii: sweet in the mouth, warm in nature, return spleen, kidney, large intestine channel, there is kidney-replenishing, benefiting essence-blood, the effect of loosening bowel to relieve constipation, cures mainly that insufficiency of kidney-YANG, essence and blood emptyly lose, sexual impotence, infertile, soreness of the waist and knees; The cards such as dryness of the intestine constipation.
Semen Sesami Nigrum: sweet in the mouth, property is flat, enters liver, kidney, large intestine channel, has invigorating the liver and kidney, benefiting essence-blood, the effect that intestine moistening is dry, for dizziness and blurred vision, Hiccough and deaf, early whitening of beard and hair, post disease alopecia, the cards such as dryness of the intestine constipation.
The present invention also provides the preparation method of above-mentioned Chinese medicine composition, is specially:
The first step, the extraction of above-mentioned Chinese medicine composition;
Second step, the purification of extract.
The described first step is specially mixes each raw material medicaments in part by weight in described Chinese medicine, stir, add the water with respect to 6～8 times of mixture qualities, it is 2～3 that the hydrochloric acid that is 5% by volumetric concentration regulates the pH value of water, soak 1 hour～2 hours, decoct subsequently 3 hours～5 hours, decoction liquor is filtered, filtering residue adds the water with respect to 4～6 times of mixture qualities again, decoct 3 hours～5 hours, decoction liquor is filtered, decoction liquor is merged, by mass percentage concentration, be that 10% sodium hydroxide regulates pH value to 6～7, obtain extracting solution, the mastic that at 50 ℃ of extracting solution simmer down tos, relative density is 1.10～1.20, be cooled to room temperature, adding concentration is that 95% ethanol to alcohol content reaches 60%, 0 ℃ of cold preservation 12 hours, filter, filtrate decompression concentration and recovery ethanol, be concentrated into the mastic that at 50 ℃, relative density is 1.10～1.20.
Described second step is specially the thick paste that the first step is obtained and adds on the macroporous adsorptive resins of D101 type, first adopt the water of 1～2 times of column volume to rinse, adopting 3～5 times of ethanol elutions that column volume determining alcohol is 30%, adopt again the ethanol elution that 3～5 times of column volume determining alcohols are 70%, the ethanol elution that the ethanol elution that collection determining alcohol is 30% and determining alcohol are 70%, being evaporated to relative density at 50 ℃ is 1.10～1.20, add isopyknic water, 0 ℃ of cold preservation 12 hours, filter, filtrate is concentrated except desolventizing, pulverize, dry, obtain Chinese medicine composition and extract purified.
The invention provides a kind of blood-enriching oral liquid, it comprises the Chinese medicine composition that promotes that iron supplement agent absorbs and enriches blood, vitamin C, vitamin B 2, brown sugar, the water of iron supplement agent and She's amount, in described blood-enriching oral liquid, the percentage by weight of each component is respectively described Chinese medicine composition 30%～40%, vitamin C 3%～5%, vitamin B 23%～5%, brown sugar 10%～18%, the water of iron supplement agent 8%～12% and She's amount.
Wherein, in described blood-enriching oral liquid health product, the percentage by weight of each component is described Chinese medicine composition 35%, vitamin C 4%, vitamin B 24%, brown sugar 15%, the water of iron supplement agent 10% and She's amount.
Further, described blood-enriching oral liquid health product only consist of said components.
Further, the mass percent sum of above-mentioned each component of described blood-enriching oral liquid health product is 100%.
Vitamin C: claim again ascorbic acid, the ferric iron that it can make human body be difficult to absorb is reduced into ferrous iron, promotes the absorption of intestinal to ferrum, improves the utilization rate of liver to ferrum, contributes to treat iron deficiency anemia.Vitamin C can also help ferrum to transfer to ferritin from carrier transferrins.It strengthens the function of some iron enzyme activity in addition in addition.
Vitamin B 2: also claiming riboflavin, is the important composition composition of many enzyme systems in body, the B if body is deficient in vitamin 2, there will be matter and energy metabolism disorder.Vitamin B 2also be to form erythrocytic important substance.Studies have shown that, it is to promoting the important effect that is absorbed with of ferrum.Have been reported and claim to be deficient in vitamin B 2anemia of pregnant woman easily there is iron deficiency anemia.So appropriate vitamin B 2picked-up to prevention status of iron deficiency in pregnant women be highly profitable.
Brown sugar: sweet, gentle, nontoxic, enter liver, spleen.Can be used for moistening cardiopulmonary, and in help spleen, slow irritability, enriches blood, removing blood stasis with potent drugs.
Described iron supplement agent is one or more mixing in sodium iron ethylenediaminetetraacetate, iron dextran, ferrous fumarate, ferrous lactate, ferric citrate or ferrous porphyrin, be preferably ferrous porphyrin, what utilize that biological extraction separation means extracts from animal blood is a kind of biological activity heme iron to ferrous porphyrin, with respect to inorganic iron or Organic Iron, ferrous porphyrin can directly be absorbed fast and be combined with hemoglobin by intestinal epithelial cell, participates in the process of hemoglobin transportation oxygen.
The present invention also provides the preparation method of this blood-enriching oral liquid, is specially:
The first step, prepares Chinese medicine composition according to the method described above;
Second step, it is 10% soda bath that 25g dissolution of sodium hydroxide is prepared into mass percentage concentration in distilled water, slowly adds subsequently 50g ferrous porphyrin, is stirred to completely and dissolves, and obtains solution;
The 3rd step, by 75g brown sugar, 20g vitamin C, 20g vitamin B 2the Chinese medicine composition of preparing with the 175g first step slowly adds in the solution of second step acquisition, stirs completely, and pH regulated value 6～8,0 ℃ of cold preservation 12 hours, filter, with distilled water diluting to 500ml, 60～80 ℃ of hot embeddings, 121 ℃ of autoclavings, lamp inspection, check, packing.
Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure of reaching technique effect can fully understand and implement according to this.
Embodiment 1 Chinese medicine composition 1
By Radix Panacis Quinquefolii 50g, Rhizoma Atractylodis Macrocephalae 35g, Fructus Jujubae 65g, Radix Rehmanniae Preparata 85g, Arillus Longan 40g, Radix Bupleuri 35g, Fructus Lycii 55g, Radix Polygoni Multiflori 85g, Radix Angelicae Sinensis 65g, Radix Paeoniae Alba 55g, Cortex Acanthopancis 40g, Flos Rosae Chinensis 25g, Herba Cistanches 60g, Herba Erigerontis 20g, Radix Rhodiolae 25g, Radix Saniculae Astrantifoliae 35g, Fructus Hordei Germinatus 60g, Semen Euryales 50g, Colla Corii Asini 115g, Herba Lysimachiae Insignis 40g, Folium Mahoniae 25g, Herba Cynomorii 25g and Semen Sesami Nigrum 55g mix, stir, the water that adds 8kg, it is 3 that the hydrochloric acid that is 5% by volumetric concentration regulates the pH value of water, soak 1 hour～2 hours, decoct subsequently 5 hours, decoction liquor is filtered, filtering residue adds the water of 6kg again, decoct 5 hours, decoction liquor is filtered, decoction liquor is merged, by mass percentage concentration, be that 10% sodium hydroxide regulates pH value to 7, obtain extracting solution, the mastic that at 50 ℃ of extracting solution simmer down tos, relative density is 1.20, be cooled to room temperature, adding concentration is that 95% ethanol to alcohol content reaches 60%, 0 ℃ of cold preservation 12 hours, filter, filtrate decompression concentration and recovery ethanol, be concentrated into the mastic that at 50 ℃, relative density is 1.20, the thick paste of acquisition is added on the macroporous adsorptive resins of D101 type, first adopt the water of 2 times of column volumes to rinse, adopting 5 times of ethanol elutions that column volume determining alcohol is 30%, adopt again the ethanol elution that 5 times of column volume determining alcohols are 70%, the ethanol elution that the ethanol elution that collection determining alcohol is 30% and determining alcohol are 70%, being evaporated to relative density at 50 ℃ is 1.20, add isopyknic water, 0 ℃ of cold preservation 12 hours, filter, filtrate is concentrated except desolventizing, pulverize, dry, obtain Chinese medicine composition 1.
Embodiment 2 Chinese medicine compositions 2
By Radix Panacis Quinquefolii 55g, Rhizoma Atractylodis Macrocephalae 40g, Fructus Jujubae 70g, Radix Rehmanniae Preparata 90g, Arillus Longan 45g, Radix Bupleuri 35g, Fructus Lycii 60g, Radix Polygoni Multiflori 90g, Radix Angelicae Sinensis 70g, Radix Paeoniae Alba 60g, Cortex Acanthopancis 40g, Flos Rosae Chinensis 25g, Herba Cistanches 65g, Herba Erigerontis 20g, Radix Rhodiolae 25g, Radix Saniculae Astrantifoliae 35g, Fructus Hordei Germinatus 60g, Semen Euryales 50g, Colla Corii Asini 120g, Herba Lysimachiae Insignis 40g, Folium Mahoniae 25g, Herba Cynomorii 25g and Semen Sesami Nigrum 60g mix, stir, the water that adds 8.5kg, it is 3 that the hydrochloric acid that is 5% by volumetric concentration regulates the pH value of water, soak 1 hour～2 hours, decoct subsequently 4 hours, decoction liquor is filtered, filtering residue adds the water of 6.5kg again, decoct 4 hours, decoction liquor is filtered, decoction liquor is merged, by mass percentage concentration, be that 10% sodium hydroxide regulates pH value to 7, obtain extracting solution, the mastic that at 50 ℃ of extracting solution simmer down tos, relative density is 1.20, be cooled to room temperature, adding concentration is that 95% ethanol to alcohol content reaches 60%, 0 ℃ of cold preservation 12 hours, filter, filtrate decompression concentration and recovery ethanol, be concentrated into the mastic that at 50 ℃, relative density is 1.20, the thick paste of acquisition is added on the macroporous adsorptive resins of D101 type, first adopt the water of 2 times of column volumes to rinse, adopting 5 times of ethanol elutions that column volume determining alcohol is 30%, adopt again the ethanol elution that 5 times of column volume determining alcohols are 70%, the ethanol elution that the ethanol elution that collection determining alcohol is 30% and determining alcohol are 70%, being evaporated to relative density at 50 ℃ is 1.20, add isopyknic water, 0 ℃ of cold preservation 12 hours, filter, filtrate is concentrated except desolventizing, pulverize, dry, obtain Chinese medicine composition 2.
Embodiment 3
By Radix Panacis Quinquefolii 50g, Rhizoma Atractylodis Macrocephalae 35g, Fructus Jujubae 65g, Radix Rehmanniae Preparata 85g, Arillus Longan 40g, Radix Bupleuri 30g, Fructus Lycii 55g, Radix Polygoni Multiflori 85g, Radix Angelicae Sinensis 65g, Radix Paeoniae Alba 55g, Cortex Acanthopancis 35g, Flos Rosae Chinensis 20g, Herba Cistanches 60g, Herba Erigerontis 15g, Radix Rhodiolae 20g, Radix Saniculae Astrantifoliae 30g, Fructus Hordei Germinatus 55g, Semen Euryales 45g, Colla Corii Asini 115g, Herba Lysimachiae Insignis 35g, Folium Mahoniae 20g, Herba Cynomorii 20g and Semen Sesami Nigrum 55g mix, stir, the water that adds 7.5kg, it is 3 that the hydrochloric acid that is 5% by volumetric concentration regulates the pH value of water, soak 1 hour～2 hours, decoct subsequently 4 hours, decoction liquor is filtered, filtering residue adds the water of 5.5kg again, decoct 4 hours, decoction liquor is filtered, decoction liquor is merged, by mass percentage concentration, be that 10% sodium hydroxide regulates pH value to 7, obtain extracting solution, the mastic that at 50 ℃ of extracting solution simmer down tos, relative density is 1.20, be cooled to room temperature, adding concentration is that 95% ethanol to alcohol content reaches 60%, 0 ℃ of cold preservation 12 hours, filter, filtrate decompression concentration and recovery ethanol, be concentrated into the mastic that at 50 ℃, relative density is 1.20, the thick paste of acquisition is added on the macroporous adsorptive resins of D101 type, first adopt the water of 2 times of column volumes to rinse, adopting 5 times of ethanol elutions that column volume determining alcohol is 30%, adopt again the ethanol elution that 5 times of column volume determining alcohols are 70%, the ethanol elution that the ethanol elution that collection determining alcohol is 30% and determining alcohol are 70%, being evaporated to relative density at 50 ℃ is 1.20, add isopyknic water, 0 ℃ of cold preservation 12 hours, filter, filtrate is concentrated except desolventizing, pulverize, dry, obtain Chinese medicine composition 3.
Embodiment 4 blood-enriching oral liquids 1
It is 10% soda bath that 25g dissolution of sodium hydroxide is prepared into mass percentage concentration in distilled water, slowly add subsequently 50g ferrous porphyrin (bio tech ltd, Hui Kang source, Beijing provides), be stirred to completely and dissolve, obtain solution, by 75g brown sugar, 20g vitamin C, 20g vitamin B 2slowly add in the solution obtaining above with the Chinese medicine composition 1 of 175g embodiment 1 preparation, stir completely, pH regulated value 7,0 ℃ of cold preservation 12 hours, filter, with distilled water diluting to 500ml, 70 ℃ of hot embeddings, 121 ℃ of autoclavings, lamp inspection, check, packing.
Embodiment 5 blood-enriching oral liquids 2
It is 10% soda bath that 25g dissolution of sodium hydroxide is prepared into mass percentage concentration in distilled water, slowly add subsequently 50g ferrous porphyrin (bio tech ltd, Hui Kang source, Beijing provides), be stirred to completely and dissolve, obtain solution, by 75g brown sugar, 20g vitamin C, 20g vitamin B 2slowly add in the solution obtaining above with the Chinese medicine composition 2 of 175g embodiment 2 preparations, stir completely, pH regulated value 7,0 ℃ of cold preservation 12 hours, filter, with distilled water diluting to 500ml, 70 ℃ of hot embeddings, 121 ℃ of autoclavings, lamp inspection, check, packing.
Embodiment 6 blood-enriching oral liquids 3
It is 10% soda bath that 25g dissolution of sodium hydroxide is prepared into mass percentage concentration in distilled water, slowly add subsequently 50g ferrous porphyrin (bio tech ltd, Hui Kang source, Beijing provides), be stirred to completely and dissolve, obtain solution, by 75g brown sugar, 20g vitamin C, 20g vitamin B 2slowly add in the solution obtaining above with the Chinese medicine composition 3 of 175g embodiment 3 preparations, stir completely, pH regulated value 7,0 ℃ of cold preservation 12 hours, filter, with distilled water diluting to 500ml, 70 ℃ of hot embeddings, 121 ℃ of autoclavings, lamp inspection, check, packing.
The pharmacology test of embodiment 7 Chinese medicine compositions
Acute toxicity test
Choose 30 kunming mices, by Qingdao City's laboratory animal and zoopery center, provided, be divided into three groups, be respectively 1 group of Chinese medicine composition, 3 groups of 2 groups of Chinese medicine compositions and Chinese medicine compositions, the Chinese medicine composition of oral administration gavage embodiments of the invention 1 to embodiment 3 preparation, Chinese medicine composition is dissolved in to gavage in distilled water, under 750g crude drug/kg dosage, after administration, mice occurs that light activity reduces, about 1 hour, recover normal, after administration, Continuous Observation is 7 days, none animal dead, its overall health of patients, diet, take the photograph water, urine and body weight gain are all normal, experimental result shows: the maximum dosage-feeding of mice oral administration gavage Chinese medicine composition of the present invention is 750g crude drug/kg/d (LD50 > 750g crude drug/kg).In blood-enriching oral liquid of the present invention, every consumption per day of Chinese medicine composition is 0.3g crude drug/kg/d; Press weighing machine, the dosis tolerata of mouse stomach Chinese medicine composition of the present invention is clinical patient 2500 times.Point out this medicine acute toxicity low, clinical drug safety.
Long term toxicity test
Select 30 SD rats, by Qingdao City's laboratory animal and zoopery center, provided, be divided into three groups, give the Chinese medicine composition of embodiments of the invention 1 preparation of variable concentrations (54.0,27.0,9.0g crude drug/kg), Chinese medicine composition is dissolved in to gavage in distilled water, every day gavage once, continuous 90 days, after last administration, 24 hours each groups are lived and are killed 1/2 animal (male and female half and half), and all the other 1/2 animals continue observation and live and kill after 2 weeks.Duration of test is observed outward appearance, general behavior, food ration, the body weight change of animal, and after administration, the index checkings such as hematology's (RBC, HB, reticulocyte, PLT, CT, WBC and classification) and blood biochemical (AST, ALT, ALP, Glu, BUN, Crea, TP, T.BIL, ALB, CH0L), urine biochemistry, organ coefficient, histopathology are carried out in 90 days and drug withdrawal for 2 weeks.Result of the test shows: Chinese medicine preparation of the present invention is good at high, medium and low dosage treated animal general state, and outward appearance sign, behavioral activity, food-intake and body weight gain are all without ANOMALOUS VARIATIONS; Three dosage groups and matched group hematological examination, blood biochemical are learned, urine biochemical analysis is all in normal range, between group without significant difference; Each is organized main organs histopathological examination and shows no obvious abnormalities.These parameters drug withdrawal also has no change after 2 weeks.This test dosage is respectively 180,90,30 times of clinical medicine dose, according to result of the test Chinese medicine preparation of the present invention, in high, medium and low three dosage (54.0,27.0,9.0g crude drug/kg) administration in continuous 90 days, rat is had no significant effect, without clear and definite toxicity target organ and sensitive indicator, convalescent period observation also has no retardance toxic reaction, points out the dosage safety of Chinese medicine preparation clinical practice of the present invention higher.
Embodiment 8 zooperies
Experimental apparatus
Atomic absorption spectrophotometer (Spect r AA-20 type), F4000 spectrofluorophotometer (FDAC), Hb1002 hemoglobin determinator (Shanghai Yue Hai Huimin scientific instrument company limited), FT-630 γ-enumerator (Beijing nuclear medicine instrument plant); 3700 full-automatic blood counting instruments (U.S. Abbott).
Reagent
The oral liquid 1 of the embodiment of the present invention 4 preparations, the potassium ferricyanide, ethyl acetate, kieselguhr, sodium chloride (Guangzhou chemical reagent work); Acetic acid heparin (Tianjin Hao Nian medical product company limited); Serum ferritin and total iron binding capacity test kit (Beijing Zhong Sheng Bioisystech Co., Ltd); Low ferrum feedstuff (Shandong Center for Disease Control & Prevention's laboratory).
Laboratory animal
80 SPF level SD rats, body weight 70～90g, is provided by Qingdao City's laboratory animal and zoopery center.
Set up anemia model
80 SD rats are placed in to laboratory environment to be adapted to after 5d, 20 give normal rat normal feedstuff and normal drinking water, and as blank group, all the other 60 give low ferrum feedstuff and drink deionized water, after 20d, adopt tail blood examination and survey hemoglobin (Hb), by Hb lower than 100gL -1rat as iron deficiency anemia animal pattern.
Before modeling, the initial body weight there was no significant difference of the low ferrum feedstuff of feed conventional feed group and feed group.After modeling 7d, model group Mouse Weight, significantly lower than blank group, illustrates that model group mouse growth will be slower than normal group mice.In modeling process, observe, with blank group ratio, model group mice starts to occur palor at test 10d, and fur is coarse, sparse, and along with test period prolongation above-mentioned symptom is more obvious, health is become thin, and hair color tarnishes, and ear, claw all occur obviously pale, performance asthenia, movable minimizing, bradykinesia, likes the group of shortening into.Its performance reduces with ferrum, and anemia increases the weight of gradually, causes neural relevant with digestive functional disturbance.
Experimental technique and observation index
Anemia in Rats is divided into model group (20), positive controls (20) and blood-enriching oral liquid group (20) at random.Each treated animal of experimental session continues the low ferrum feedstuff of feed, and (gavage gives 10mLkg with drinking deionized water -1deionized water), blood-enriching oral liquid group gives blood-enriching oral liquid 2.0mlkg -1(be equivalent to human body recommended amounts every day 5 times), and positive controls separately gives ferrous sulfate 2.0mgkg -1, continuous 30d, iron content in free protoporphyrin (F EP), liver, spleen tissue in Measuring hemoglobin (Hb), RBC number (RBC), packed cell volume (HC T), erythrocyte.
Biochemical Indexes
Hemoglobin (Hb)
Adopt HemoCue Measuring hemoglobin content, with 10 μ l quantitative capillary tubes, get rat tail blood, put into the plastic tube that fills 2.5ml high-potassium ferricyanide reagent, fully vibration, make the complete stripping of blood, lucifuge is placed after 15min, measures, simultaneously Measuring hemoglobin standard and primary standard substance with Hemoglobin Meter.
Packed cell volume (HCT)
With 9 μ l quantitative capillary tubes, get blood, one end is sealed with plasticine, adopt hematocrit measurement instrument to measure, reading result after 2min is measured basis reference blood sample simultaneously.
RBC number (RBC)
With full-automatic blood counting instrument, measure.
Free erythrocyte protoporphyrin (F EP)
On special filter paper, deposit droplets of whole blood in 4 ℃ of refrigerators standby (time is no more than 2 months) after to be dried.During mensuration, with card punch, will squeeze in teat glass with the filter paper of drop of blood, add 2% tripolite solution, put into 4 ℃ of refrigerator overnight eluting, add ethyl acetate: the extraction of glacial acetic acid (4: 1) mixed liquor, centrifugal 10min, gets supernatant and adds 0.5mol/L hydrochloric acid, vibrate centrifugal, take off a layer liquid fluorescent spectrophotometer assay.
Iron content in liver, spleen tissue
After off-test, get about 0.2g tissue and put into the teat glass through hydrochloric acid dry cleansing, add nitric acid: perchloric acid (4: 1) mixed acid 2ml, after digestion, with deionized water, be settled to 5ml or 10ml, adopt flame atomization to measure iron content in tissue, each mensuration with Hepar Bovis seu Bubali powder (NBS1577a of NBS) as Quality Control material.
Statistical procedures
Adopt SPSS10.0 statistical software to carry out variance analysis to experimental data, result with
Figure BDA0000400561880000173
represent.
Result
The impact of blood-enriching oral liquid on Induced By Iron Deficiency Anemia In Rats hemoglobin, the results are shown in Table 1.
Table 1 changes before and after respectively organizing the experiment of Induced By Iron Deficiency Anemia In Rats hemoglobin
Figure BDA0000400561880000171
With model group comparison: *p < 0.01; With the comparison of blank group: #p < 0.01
As can be seen from Table 1, before test, model group, positive controls, hemoglobin and the blank group of blood-enriching oral liquid group rat have significant difference, P < 0.01, after experiment, the Hemoglobin Value of blood-enriching oral liquid group is significantly higher than before experiment, and higher than positive controls and model group, shows that blood-enriching oral liquid can significantly promote the Hemoglobin Value of rat.
The impact of blood-enriching oral liquid on Induced By Iron Deficiency Anemia In Rats RBC, HCT, the results are shown in Table 2.
Table 2 changes before and after respectively organizing Induced By Iron Deficiency Anemia In Rats RBC, HCT experiment
Figure BDA0000400561880000172
With model group comparison: *p < 0.01; With the comparison of blank group: #p < 0.01
As can be seen from Table 2, before test, model group, positive controls, the RBC number of blood-enriching oral liquid group and packed cell volume value and blank group have significant difference, P < 0.01, after experiment, the RBC number of blood-enriching oral liquid group and packed cell volume value are significantly higher than before experiment, and higher than positive controls and model group, show that blood-enriching oral liquid has remarkable facilitation to the RBC number of rat and packed cell volume value.
The impact of blood-enriching oral liquid on Induced By Iron Deficiency Anemia In Rats F EP, the results are shown in Table 3.
Table 3 changes before and after respectively organizing Induced By Iron Deficiency Anemia In Rats F EP experiment
Figure BDA0000400561880000181
With model group comparison: *p < 0.01; With the comparison of blank group: #p < 0.01
As can be seen from Table 3, before test, model group, positive controls, free erythrocyte protoporphyrin content and the blank group of blood-enriching oral liquid group have significant difference, P < 0.01, after experiment, the free erythrocyte protoporphyrin content of blood-enriching oral liquid group is significantly higher than before experiment, and higher than positive controls and model group, shows that blood-enriching oral liquid has remarkable reducing effect to the free erythrocyte protoporphyrin content of rat.
The impact of blood-enriching oral liquid on iron content in Induced By Iron Deficiency Anemia In Rats liver and spleen tissue, the results are shown in Table 4 and table 5.
Table 4 is respectively organized iron content in liver organization
Figure BDA0000400561880000182
Compare with model group, *p < 0.05
Table 5 is respectively organized iron content in spleen tissue
Figure BDA0000400561880000183
Figure BDA0000400561880000191
Compare with model group, *p < 0.05
From table 4 and table 5, can find out, before experiment, respectively organize liver and the spleen weight difference not statistically significant (P > 0.05) of rat, after experiment, in the rat liver of blood-enriching oral liquid group and spleen, iron content and total iron content are all significantly higher than model group, and higher than positive controls.
From data above, Chinese medicine composition blood-enriching oral liquid provided by the invention has the effect that improves rat iron deficiency anemia.
Embodiment 9 clinical datas
The patient who selects 173 examples to be diagnosed as iron deficiency anemia and to obtain informed consent through health check-up carries out this observation of curative effect.Be divided at random treatment group 100 examples, male 53 examples wherein, female's 47 examples; At 20～72 years old age, matched group is totally 73 examples, male's 40 examples wherein, women's 33 examples, 23～69 years old age.The Hb level of all patients is all lower than 120g/L, meets in WHO the diagnostic criteria about anemia.Two groups of patients' mean age, M-F, the clinical data aspect no significant differences such as the state of an illness, have comparability.
Therapeutic Method
(ferrous sulfate controlled release tablet, Guangzhou Mai Te Xinghua pharmaceutical factory produces, and 0.2g/ time, every day 3 times, serve on 2 weeks to take merely Ferroids.After, Anemia normal until Hemoglobin Value corrected, by 2mg/kg, weekly 1 time oral, serve on 10 weeks.Coordinate folic acid, vitamin C, pepsin mixture etc. simultaneously.Have and infect symptom and add anti-infective, the person's anthelmintic that has parasitosis.
The blood-enriching oral liquid of the oral embodiment of the present invention 4 preparations for the treatment of group, morning, noon and afternoon every day respectively take 1 time, and each 15ml, serve on 2 weeks, treats Anemia correction, and after hemoglobin is normal, following the service more than 8 weeks, is consolidated curative effect.
Criterion of therapeutical effect
Cure: clinical symptoms is obviously improved.Male: Hb > 120g/L, RBC > 4 * 10 12/ L.Women: Hb > 110g/L, RBC > 3.5 * 10 12/ L.Take a turn for the better: 20g/L at least rises before within 8 weeks, interior Hb treats.Invalid: not reach above-mentioned standard.
Statistical procedures
Adopt SPSS10.0 statistical software to carry out variance analysis to experimental data, result with
Figure BDA0000400561880000192
represent.
Two groups of therapeutic effect comparisons, the results are shown in Table 6.
Table 6 liang group therapeutic effect comparison
Group Number of cases Cure Take a turn for the better Invalid Effective percentage (%)
Treatment group 100 87 10 3 97％
Matched group 73 32 26 15 79.5％
As can be seen from Table 6, adopt Chinese medicine composition blood-enriching oral liquid of the present invention can significantly improve the situation of patient's iron deficiency anemia.
Two groups of anemia experimental index are observed, and the results are shown in Table 7.
A table 7 liang group anemia experimental index is observed
Relatively front with treatment: *p < 0.05
As can be seen from Table 7, adopt Chinese medicine composition blood-enriching oral liquid of the present invention can significantly improve lab index RBC, Hb, the HCT of anemia.
The comparison of two groups of adverse reactions of patients situation occurreds, the results are shown in Table 8.
Table 8 liang group infant untoward reaction situation occurred comparison
Group Number of cases Inappetence Nausea and vomiting Epigastric discomfort Diarrhoea Fraction defective
Treatment group 100 1 0 3 2 6％
Matched group 73 5 3 6 3 23.2％
As can be seen from Table 8, Chinese medicine composition blood-enriching oral liquid provided by the invention untoward reaction is few, is a kind of good blood-tonifying health-care product.
All above-mentioned these intellectual properties of primary enforcement, do not set restriction this new product of other forms of enforcement and/or new method.Those skilled in the art will utilize this important information, and foregoing is revised, to realize similar implementation status.But all modifications or transformation belong to the right of reservation based on new product of the present invention.
The above, be only preferred embodiment of the present invention, is not the present invention to be done to the restriction of other form, and any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the equivalent embodiment of equivalent variations.But every technical solution of the present invention content that do not depart from, any simple modification, equivalent variations and the remodeling above embodiment done according to technical spirit of the present invention, still belong to the protection domain of technical solution of the present invention.

Claims (10)

1. there is a Chinese medicine composition that promotes that ferrous components absorbs and enriches blood, it is characterized in that: the crude drug of described Chinese medicine composition comprises Radix Panacis Quinquefolii, the Rhizoma Atractylodis Macrocephalae, Fructus Jujubae, Radix Rehmanniae Preparata, Arillus Longan, Radix Bupleuri, Fructus Lycii, Radix Polygoni Multiflori, Radix Angelicae Sinensis, the Radix Paeoniae Alba, Cortex Acanthopancis, Flos Rosae Chinensis, Herba Cistanches, Herba Erigerontis, Radix Rhodiolae, Radix Saniculae Astrantifoliae, Fructus Hordei Germinatus, Semen Euryales, Colla Corii Asini, Herba Lysimachiae Insignis, Folium Mahoniae, Herba Cynomorii and Semen Sesami Nigrum.
2. Chinese medicine composition as claimed in claim 1, is characterized in that: in described Chinese medicine composition, the weight of each raw material is respectively Radix Panacis Quinquefolii 45 weight portion～55 weight portions, the Rhizoma Atractylodis Macrocephalae 30 weight portion～40 weight portions, Fructus Jujubae 60 weight portion～70 weight portions, Radix Rehmanniae Preparata 80 weight portion～90 weight portions, Arillus Longan 35 weight portion～45 weight portions, Radix Bupleuri 30 weight portion～40 weight portions, Fructus Lycii 50 weight portion～60 weight portions, Radix Polygoni Multiflori 80 weight portion～90 weight portions, Radix Angelicae Sinensis 60 weight portion～70 weight portions, the Radix Paeoniae Alba 50 weight portion～60 weight portions, Cortex Acanthopancis 35 weight portion～45 weight portions, Flos Rosae Chinensis 20 weight portion～30 weight portions, Herba Cistanches 55 weight portion～65 weight portions, Herba Erigerontis 15 weight portion～25 weight portions, Radix Rhodiolae 20 weight portion～30 weight portions, Radix Saniculae Astrantifoliae 30 weight portion～40 weight portions, Fructus Hordei Germinatus 55 weight portion～65 weight portions, Semen Euryales 45 weight portion～55 weight portions, Colla Corii Asini 110 weight portion～120 weight portions, Herba Lysimachiae Insignis 35 weight portion～45 weight portions, Folium Mahoniae 20 weight portion～30 weight portions, Herba Cynomorii 20 weight portion～30 weight portions and Semen Sesami Nigrum 50 weight portion～60 weight portions.
3. Chinese medicine composition as claimed in claim 1 or 2, it is characterized in that: in described Chinese medicine composition, the weight portion of each raw material is Radix Panacis Quinquefolii 50 weight portions, the Rhizoma Atractylodis Macrocephalae 35 weight portions, Fructus Jujubae 65 weight portions, Radix Rehmanniae Preparata 85 weight portions, Arillus Longan 40 weight portions, Radix Bupleuri 35 weight portions, Fructus Lycii 55 weight portions, Radix Polygoni Multiflori 85 weight portions, Radix Angelicae Sinensis 65 weight portions, the Radix Paeoniae Alba 55 weight portions, Cortex Acanthopancis 40 weight portions, Flos Rosae Chinensis 25 weight portions, Herba Cistanches 60 weight portions, Herba Erigerontis 20 weight portions, Radix Rhodiolae 25 weight portions, Radix Saniculae Astrantifoliae 35 weight portions, Fructus Hordei Germinatus 60 weight portions, Semen Euryales 50 weight portions, Colla Corii Asini 115 weight portions, Herba Lysimachiae Insignis 40 weight portions, Folium Mahoniae 25 weight portions, Herba Cynomorii 25 weight portions and Semen Sesami Nigrum 55 weight portions.
4. the preparation method of Chinese medicine composition described in claims 1 to 3, is characterized in that:
The first step, the extraction of traditional Chinese medicinal composition raw materials described in claims 1 to 3;
Second step, the purification of extract.
5. the preparation method of Chinese medicine composition as claimed in claim 4, it is characterized in that: the described first step is specially mixes each raw material medicaments in part by weight in described Chinese medicine composition, stir, add the water with respect to 6～8 times of mixture qualities, it is 2～3 that the hydrochloric acid that is 5% by volumetric concentration regulates the pH value of water, soak 1 hour～2 hours, decoct subsequently 3 hours～5 hours, decoction liquor is filtered, filtering residue adds the water with respect to 4～6 times of mixture qualities again, decoct 3 hours～5 hours, decoction liquor is filtered, decoction liquor is merged, by mass percentage concentration, be that 10% sodium hydroxide regulates pH value to 6～7, obtain extracting solution, the mastic that at 50 ℃ of extracting solution simmer down tos, relative density is 1.10～1.20, be cooled to room temperature, adding concentration is that 95% ethanol to alcohol content reaches 60%, 0 ℃ of cold preservation 12 hours, filter, filtrate decompression concentration and recovery ethanol, be concentrated into the mastic that at 50 ℃, relative density is 1.10～1.20.
6. the preparation method of the Chinese medicine composition as described in claim 4 or 5, it is characterized in that: described second step is specially the thick paste that the first step is obtained and adds on the macroporous adsorptive resins of D101 type, first adopt the water of 1～2 times of column volume to rinse, adopting 3～5 times of ethanol elutions that column volume determining alcohol is 30%, adopt again the ethanol elution that 3～5 times of column volume determining alcohols are 70%, the ethanol elution that the ethanol elution that collection determining alcohol is 30% and determining alcohol are 70%, being evaporated to relative density at 50 ℃ is 1.10～1.20, add isopyknic water, 0 ℃ of cold preservation 12 hours, filter, filtrate is concentrated except desolventizing, pulverize, dry, obtain Chinese medicine composition and extract purified.
7. blood-tonifying health-care product, is characterized in that: comprise the Chinese medicine composition that claims 1 to 3 is stated, vitamin C, vitamin B 2, brown sugar, the water of iron supplement agent and She's amount.
8. blood-tonifying health-care product as claimed in claim 7, is characterized in that: in described blood-tonifying health-care product, the percentage by weight of each component is respectively described Chinese medicine composition 30%～40%, vitamin C 3%～5%, vitamin B 23%～5%, brown sugar 10%～18%, the water of iron supplement agent 8%～12% and She's amount.
9. blood-tonifying health-care product as claimed in claim 7 or 8, is characterized in that: in described blood-tonifying health-care product, the percentage by weight of each component is described Chinese medicine composition 35%, vitamin C 4%, vitamin B 24%, brown sugar 15%, the water of iron supplement agent 10% and She's amount.
10. the preparation method of blood-tonifying health-care product described in claim 7 to 9, is characterized in that:
The first step, prepares Chinese medicine composition according to the method described in claim 4 to 6;
Second step, it is 10% soda bath that 25g dissolution of sodium hydroxide is prepared into mass percentage concentration in distilled water, slowly adds subsequently 50g ferrous porphyrin, is stirred to completely and dissolves, and obtains solution;
The 3rd step, Chinese medicine composition prepared by 75g brown sugar, 20g vitamin C, 20g vitamin B2 and the 175g first step slowly adds in the solution of second step acquisition, stir completely, pH regulated value 6～8,0 ℃ of cold preservation 12 hours, filter, with distilled water diluting to 500ml, 60～80 ℃ of hot embeddings, 121 ℃ of autoclavings, lamp inspection, check, packing.
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CN104921061A (en) * 2015-05-26 2015-09-23 合肥市金乡味工贸有限责任公司 Roe sweet soybean paste and preparation method thereof
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CN116870067A (en) * 2023-08-10 2023-10-13 上海纳米技术及应用国家工程研究中心有限公司 Traditional Chinese medicine composition for relieving VB12 malabsorption and preparation method thereof

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