CN103735937B - There is the medicine and health products promoting ferrous components to absorb and to enrich blood - Google Patents

There is the medicine and health products promoting ferrous components to absorb and to enrich blood Download PDF

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CN103735937B
CN103735937B CN201310504274.XA CN201310504274A CN103735937B CN 103735937 B CN103735937 B CN 103735937B CN 201310504274 A CN201310504274 A CN 201310504274A CN 103735937 B CN103735937 B CN 103735937B
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孙霞
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Kaiputai (Beijing) Medical Technology Co Ltd
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杨高林
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Abstract

The invention provides a kind of Chinese medicine composition health products having and promoting that ferrous components absorbs and enriches blood, its bulk drug includes American Ginseng, the bighead atractylodes rhizome, date, prepared rhizome of rehmannia, arillus longan, radix bupleuri, the fruit of Chinese wolfberry, the fleece-flower root, Radix Angelicae Sinensis, the root of herbaceous peony, cortex acanthopanacis, China rose, saline cistanche, erigeron breviscapus, rhodiola root, szechwan-Yunnan sanicle root, Fructus Hordei Germinatus, Gorgon fruit, donkey-hide gelatin, threeleaf loosestrife herb, Chinese holly leaf, cynomorium songaricum and Semen sesami nigrum.The Chinese medicine composition that the present invention provides can more effectively promote the body absorption to iron, can be used for preventing and treating in daily life hypoferric anemia, and in good taste, non-stimulated to stomach and intestine.

Description

There is the medicine and health products promoting ferrous components to absorb and to enrich blood
Technical field
The present invention relates to health product technology field, particularly relate to a kind of for preventing and treating hypoferric anemia Have and promote ferrous components to absorb and the medicine enriched blood and health products.
Background technology
Hypoferric anemia, is a kind of trace element deficiency that the incidence of disease is the highest, is a kind of common nutrition Deficiency disease, whole world Anemic patients is more than 2,000,000,000, and wherein 50% belongs to hypoferric anemia, and China occupies The average prevalence of anemia of the people reaches 20.1%.Among the crowd being generally considered to be " normal person ", there are about The people of 11% is in hypoferric anemia state, and especially in children and adolescent girls, this has become as one The individual clinical treatment problem highly paid attention to.
Anaemia is not showed only as the symptom such as ochrodermia, palpitation, is also frequently accompanied by muscle power, endurance And study, the decline of labour capacity, lassitude and weak is the disease that anemia is most common and occurs the earliest One of shape.
Hypoferric anemia because of internal storage asiderosis, affect ferroheme synthesis and cause, be characterized in Marrow, liver, spleen lack stainability iron, cause the reason of iron deficiency mainly to have: the requirement of iron increases and takes the photograph Enter deficiency, the malabsorption of iron or lose blood.In adult, chronic the most hemorrhage be also to cause iron deficiency The property modal reason of anaemia.
In order to improve hypoferric anemia, current western medicine mainly uses iron supplementary, uses iron in treatment The purpose of hypoferric anemia has two, and one is to provide the ferro element required for synthetic hemoglobin, reverses and lacks The pathophysiological change that iron loss itself and anaemia cause, improves the symptom of anaemia, and two is to supplement body Chu Storage iron in iron pond (such as marrow, spleen etc.), thus fundamentally improve the Iron status of body, make Body is unlikely in the case of short-term or slight iron imbalance of supply and demand again to affect hemoglobin synthesis, causes Anaemia, uses iron in treatment, and clinical efficacy is rapid, but easily causes the bad reaction of intestines and stomach etc., leads Cause the generation of the symptoms such as diarrhoea, vomiting, owing to body exists bigger individual difference to absorption and the metabolism of iron Different, the time phase difference required for the therapeutic purposes reach different patients is very big, and the course for the treatment of is not enough, and anaemia is not Can improve or storage iron can not get supplying, Clinical observations, in causing the body of iron, excess is piled up, to machine Body produces a series of harmful effect.
In general, ferrous iron relatively ferric iron is more beneficial for absorption of human body.Although having various currently on the market The benefit iron food of various kinds and preparation, but it is true that the benefit iron effect of these products is unsatisfactory.This side The approach that face is likely due to iron absorption is the most correct, and ferrous sulfate tablet is such as administered orally, although take Ferrous sulfate amount is relatively big, but body has no ability to absorb the biggest amount, so major part iron is depleted again Falling, only small part is absorbed by organisms and plays physiological function；On the other hand iron strengthening it is likely due to Food is not fully utilized in entering human body, and bioavailability depends on the chemical shape of element itself State and the content in food, be likely to be due to dosage form or preservation is improper, quite a few iron preparation In ferrous iron be oxidized to ferric iron entering before human body, lose the value that body utilizes；It addition, Even if human body has taken in enough iron, but plays a role without being fully absorbed, or due to multiple Interaction between nutrient and cause the absorption of ferro element to suppress so that it is be not fully used, The most still can not alleviate sideropenic present situation, therefore, also need to develop height and send more effective high biological utilisation The iron fortified food product of degree or preparation, in order to prevent and treat hypoferric anemia.
The traditional Chinese medical science is thought, anaemia belongs to the category of " syndrome of blood deficiency ", by " shape deficiency person, warming with drugs of thick nature, insufficiency of essence Person, tonifying with drugs of thick flavor " principle, make up a deficiency, train that it is basic, strengthening the spleen and stomach, strengthen self resistance against diseases, Promoting it to absorb and green blood function, treating deficiency with tonification, this disease mainly eating and drinking without temperance, insufficiency of natural endowment, prolonged illness are not More, infect caused by the reasons such as parasites.Blood stored in the liver, there is storage blood, regulate blood volume, prevent out The function of blood, liver master dredges rushes down, and can regulate mechanism of qi, helps transporting and transforming function of the spleen and stomach, taste the foundation of acquired constitution, and qi and blood is raw The source of change, the dirty of blood of uniting, liver and regulating qi, mechanism of qi fluent then taste metaplasia blood is normal, and qi and blood is the most raw, gas Blood is in internal, and more bad in the catharsis effect of liver, blood stored in the liver complements each other with The spleen governs the blood, common anti-hemostasis Overflow outside arteries and veins, qi promoting blood production, therefore enrich blood and need to take into account tonifying Qi, qi and blood is with mending, and invigorating the spleen helps fortune.In the side's of enriching blood medicine In, compatibility tonifying Qi medicine, the effect of qi-supplementing, blood-engendering can be received, Chinese medicine preparation is better than being administered orally in terms of improving symptom Chalybeate, and GI function is had improvement result, it is difficult to recurrence after drug withdrawal, during this points out us to utilize Doctor's Coryza Treated by Syndrome Differentiation, the characteristic of the performance traditional Chinese medical science is to improve clinical efficacy, and can play what the traditional Chinese medical science was preventiveed treatment of disease Advantage.
Summary of the invention
The technical problem to be solved is to provide a kind of health products for preventing and treating hypoferric anemia, It can more effectively promote the body absorption to iron, can be used for preventing and treating in daily life hypoferric anemia, And in good taste, non-stimulated to stomach and intestine.
For solving above-mentioned technical problem, the invention provides one and there is promotion ferrous components absorption and enrich blood Chinese medicine composition, its bulk drug include American Ginseng, the bighead atractylodes rhizome, date, prepared rhizome of rehmannia, arillus longan, radix bupleuri, The fruit of Chinese wolfberry, the fleece-flower root, Radix Angelicae Sinensis, the root of herbaceous peony, cortex acanthopanacis, China rose, saline cistanche, erigeron breviscapus, red scape My god, szechwan-Yunnan sanicle root, Fructus Hordei Germinatus, Gorgon fruit, donkey-hide gelatin, threeleaf loosestrife herb, Chinese holly leaf, cynomorium songaricum and Semen sesami nigrum.
Wherein, in described Chinese medicine composition, the weight of each raw material is respectively American Ginseng 45 weight portion～55 weights Amount part, the bighead atractylodes rhizome 30 weight portion～40 weight portions, date 60 weight portion～70 weight portions, prepared rhizome of rehmannia 80 Weight portion～90 weight portions, arillus longan 35 weight portion～45 weight portions, radix bupleuri 30 weight portion～40 weights Amount part, the fruit of Chinese wolfberry 50 weight portion～60 weight portions, the fleece-flower root 80 weight portion～90 weight portions, Radix Angelicae Sinensis 60 weight portions～70 weight portions, the root of herbaceous peony 50 weight portion～60 weight portions, cortex acanthopanacis 35 weight portion～45 Weight portion, China rose 20 weight portion～30 weight portions, saline cistanche 55 weight portion～65 weight portions, oil lamp The root of Chinese wild ginger 15 weight portion～25 weight portions, rhodiola root 20 weight portion～30 weight portions, szechwan-Yunnan sanicle root 30 weight Part～40 weight portions, Fructus Hordei Germinatus 55 weight portion～65 weight portions, Gorgon fruit 45 weight portion～55 weight portions, Donkey-hide gelatin 110 weight portion～120 weight portions, threeleaf loosestrife herb 35 weight portion～45 weight portions, Chinese holly leaf 20 weight Measure part～30 weight portions, cynomorium songaricum 20 weight portion～30 weight portions and Semen sesami nigrum 50 weight portion～60 weight Part.
Wherein, in described Chinese medicine composition, the weight portion of each raw material is American Ginseng 50 weight portion, the bighead atractylodes rhizome 35 Weight portion, date 65 weight portion, prepared rhizome of rehmannia 85 weight portion, arillus longan 40 weight portion, radix bupleuri 35 weight Amount part, the fruit of Chinese wolfberry 55 weight portion, the fleece-flower root 85 weight portion, Radix Angelicae Sinensis 65 weight portion, the root of herbaceous peony 55 weight Part, cortex acanthopanacis 40 weight portion, China rose 25 weight portion, saline cistanche 60 weight portion, erigeron breviscapus 20 Weight portion, rhodiola root 25 weight portion, szechwan-Yunnan sanicle root 35 weight portion, Fructus Hordei Germinatus 60 weight portion, Gorgon fruit 50 weight Amount part, donkey-hide gelatin 115 weight portion, threeleaf loosestrife herb 40 weight portion, Chinese holly leaf 25 weight portion, cynomorium songaricum 25 weight Part and Semen sesami nigrum 55 weight portion.
Present invention also offers the preparation method of above-mentioned Chinese medicine composition, particularly as follows:
The first step, the extraction of above-mentioned traditional Chinese medicinal composition raw materials；
Second step, the purifying of extract.
Wherein, the described first step is specially and each raw material medicaments in part by weight in described Chinese medicine is mixed, and stirring is all Even, add relative to mixture quality 6～the water of 8 times, with the hydrochloric acid regulation water that volumetric concentration is 5% PH value is 2～3, soaks 1 hour～2 hours, decocts 3 hours～5 hours subsequently, and decoction liquor filters, Filter residue adds relative to mixture quality 4～the water of 6 times again, decocts 3 hours～5 hours, decoction liquor mistake Filter, by decoction liquor merge, with mass percentage concentration be 10% NaOH regulation pH value to 6～7, obtain Obtaining extract, it is that at 50 DEG C, relative density is the lotion of 1.10～1.20 that extract concentrates, and is cooled to room temperature, Add the ethanol that concentration is 95% and reach 60% to alcohol content, refrigerate 12 hours at 0 DEG C, filter, filter Liquid reduced pressure concentration reclaims ethanol, and being concentrated into relative density at 50 DEG C is the lotion of 1.10～1.20.
Wherein, described second step is specially the macroporous absorption of the thick paste addition D101 type first step obtained On resin column, first use the water of 1～2 times of column volume to rinse, be 30% using 3～5 times of column volume determining alcohols Ethanol elution, then to use 3～5 times of column volume determining alcohols be the ethanol elution of 70%, and collecting determining alcohol is The ethanol eluate of 30% and determining alcohol are the ethanol eluate of 70%, are evaporated at 50 DEG C the closeest Degree is 1.10～1.20, adds isopyknic water, refrigerates 12 hours at 0 DEG C, filters, and filtrate concentrates and removes Remove solvent, pulverize, be dried, it is thus achieved that Chinese medicine composition extraction purification thing.
Present invention also offers a kind of blood-enriching oral liquid, it includes above-mentioned Chinese medicine composition, vitamin C, Cobastab2, brown sugar, iron supplementary and the water of She's amount.
Wherein, in described blood-enriching oral liquid, the percentage by weight of each component is respectively described Chinese medicine composition 30 %～40%, vitamin C 3%～5%, Cobastab23%～5%, brown sugar 10%～18%, iron supplementary 8%～12% and She amount water.
Wherein, in described blood-enriching oral liquid health products, the percentage by weight of each component is described Chinese medicine composition 35%, vitamin C 4%, Cobastab24%, brown sugar 15%, iron supplementary 10% and the water of She's amount.
Present invention also offers the preparation method of this blood-enriching oral liquid, particularly as follows:
The first step, prepares Chinese medicine composition according to the method described above；
Second step, being dissolved in distilled water by 25g NaOH and being prepared as mass percentage concentration is 10% Soda bath, is then slowly added to 50g PORPHYRIN IRON, and stirring is to being completely dissolved, it is thus achieved that solution；
3rd step, by 75g brown sugar, 20g vitamin C, 20g Cobastab2Prepare with the 175g first step Chinese medicine composition be slowly added in the solution that second step obtains, stirring completely, solution ph regulated value 6～8, refrigerate 12 hours at 0 DEG C, filter, with distilled water diluting to 500ml, 60～80 DEG C of hot embeddings, 121 DEG C of autoclavings, lamp inspection, inspection, packaging.
Beneficial effects of the present invention:
Chinese medicine composition and blood-enriching oral liquid health products that the present invention provides can more effectively promote body pair The absorption of iron, can be used for preventing and treating in daily life hypoferric anemia, and in good taste, stingless to stomach and intestine Swash.
Detailed description of the invention
The traditional Chinese medical science is thought, anaemia belongs to the category of " syndrome of blood deficiency ".Treating deficiency with tonification, this disease mainly eating and drinking without temperance, Caused by the reasons such as insufficiency of natural endowment, obstinate disease, infection parasites.
The root that kidney asthenia as the principal aspect is sick, kidney storing essence, the raw marrow of main bone, essence can change blood, marrow energy green blood, essence and blood with Source, then essence and blood source of suffering from a deficiency of the kidney is not enough, and temper depends on the warm of the yang-energy of kidney can the precise and tiny change of normal metaplastic Turning to blood, marrow virtual loss of suffering from a deficiency of the kidney then blood must be empty few.Kidney is that whole body vigour is basic, kidney storing essence, raw marrow, Main bone, therefore kidney essense is abundant, then can change and be blood.Modern study thinks that traditional Chinese medical science invigorating kidney, promoting blood circulation can regulate machine Body immunity function, stimulates hemopoietic function of bone marrow, improves bone marrow microenvironment, make decreased hemoglobin the most sick The removal of cause still regenerates recovery and all plays an important role.Modern medicine thinks that marrow, liver, spleen etc. are for storage The organ of iron, iron is the main component of synthetic hemoglobin, thinks that kidney controlling essence storage, main bone give birth to marrow with the traditional Chinese medical science, Marrow green blood has points of resemblance.
Taste are the key of this disease, and spleen and kidney are the relation of " day after tomorrow " and " congenital ", are mutual promotions, Mutually promote, pathology also influences each other, reciprocal causation.The insufficiency of the kidney yang can not warm spleen sun；Spleen sun Weak, it is impossible to transporting and transforming nutrients from foodstuff is precise and tiny, and kidney yang is lost it and supplemented nutrition." qi being the governor of blood, blood being the material foundation of QI ", Gas and blood have therebetween contact closely.Qi promoting blood production, refers to composition and the generation process thereof of blood In, all it be unable to do without gas gentle motion change one gasification function.Ying-qi and body fluid, be mainly comprising of blood Part, they are from the essence of water and grain of taste institute transporting.Essence of water and grain is changed into from the ingesta taken in, It is then converted into ying-qi and body fluid, is then converted into blood, all be unable to do without the motion change of gas.Invigorating the spleen can supplement The deficiency of taste, provides home for qi and blood biochemistry, and tonifying Qi can be invigorated blood circulation green blood.The generation of blood and spleen Relation the closest." blood person's essence of water and grain metaplasia is in spleen ", " spleen is source of generating QI and blood ".Spleen Stomach is received digesting food, produces cereal nutrient, and the generation for blood provides material source, the metaplasia function of spleen It is the power of blood generation.Temper also has has the function that blood is properly functioning under one's command.Eating and drinking without temperance, overstrain Excessively, the many reasons such as weakness due to chronic disease all can undermine spleen and stomach function, cause water paddy and received deficiency, cause precise and tiny The weary source of material, or spleen metaplasia miopragia, precise and tiny Use barriers occur, thus cause this disease to occur.Spleen The deficiency of vital energy is weak, has dereliction of duty under one's command, and blood overflows outside arteries and veins, and Massive Bleeding (acute or chronic) also can cause this disease.
" qi being the governor of blood, blood being the material foundation of QI ", gas and blood have therebetween contact closely.Gas energy Green blood, during referring to composition and the generation thereof of blood, all be unable to do without gas gentle motion change one gasification Function.Ying-qi and body fluid, be the chief component of blood, and they are from the essence of water and grain of taste institute transporting. From take in ingesta change into essence of water and grain, be then converted into ying-qi and body fluid, be then converted into blood, all from Do not open the motion change of gas.Therefore say, qi promoting blood production.Gas is prosperous, then the function of metaplasia blood is the strongest；The deficiency of vital energy, Then the function of metaplasia blood is the most weak, the most then can cause the deficiency of blood.
Blood stored in the liver, having storage blood, regulate blood volume, prevent hemorrhage function, liver master dredges rushes down, permissible Regulation mechanism of qi, helps transporting and transforming function of the spleen and stomach, taste the foundation of acquired constitution, source of generating QI and blood, the dirty of blood of uniting, liver and regulating qi, Mechanism of qi fluent then taste metaplasia blood is normal, and qi and blood is the most raw, and qi and blood row is in internal, more bad in the catharsis of liver Effect, blood stored in the liver complements each other with The spleen governs the blood, and common anti-hemostasis is overflow outside arteries and veins, qi promoting blood production, therefore enriches blood and need Taking into account tonifying Qi, qi and blood is with mending, and invigorating the spleen helps fortune.In the side's of enriching blood medicine, compatibility tonifying Qi medicine, tonifying Qi can be received The effect of green blood.
Theoretical based on above-mentioned Chinese traditional treatment, the present invention proposes with strengthening the spleen and replenishing qi, promoting blood circulation for regulating menstruation, soothing the liver enriches blood For principle, it is provided that a kind of for preventing and treating there is promotion ferrous components absorption and mending of hypoferric anemia The Chinese medicine composition of blood, its bulk drug includes American Ginseng, the bighead atractylodes rhizome, date, prepared rhizome of rehmannia, arillus longan, bavin Recklessly, the fruit of Chinese wolfberry, the fleece-flower root, Radix Angelicae Sinensis, the root of herbaceous peony, cortex acanthopanacis, China rose, saline cistanche, erigeron breviscapus, Rhodiola root, szechwan-Yunnan sanicle root, Fructus Hordei Germinatus, Gorgon fruit, donkey-hide gelatin, threeleaf loosestrife herb, Chinese holly leaf, cynomorium songaricum and Semen sesami nigrum.
Fang Zhong, American Ginseng contains the total soap of ginseng two, and the total soap of ginseng two the most all can stimulate candidate stem cell With the propagation of HPC, having effect of similar hemopoieticgrowth factor, the bighead atractylodes rhizome can increase digestive system Secretion, stimulate hemopoietic system, raise red blood cell and hemoglobin, improve lymphocyte transformation rate, dragon Eye meat tonifying kidney and benefiting sperm, nourishing qi and blood, prepared rhizome of rehmannia can stimulate hemopoietic system, raises red blood cell, and date contains Vitamin C, iron etc., can increase gastric enzyme, promotes the absorption of iron, and the fleece-flower root can stimulate Hemopoietic factor to secrete, Erythrocytic growing and the synthesis of hemoglobin can be promoted, gas reason spleen of waking up, radix bupleuri dispersing stagnated hepatoqi, Chinese holly Matrimony vine is nourishing liver and kidney, controls the deficiency of blood sallow, can subsidize essence and blood with the fleece-flower root, Radix Angelicae Sinensis compatibility, enriching yin with pig sample, The fruit of Chinese wolfberry can also immune stimulatory hemopoietic system, Radix Angelicae Sinensis is pungent sweet and warm, enriches blood and seeks, contained vitamin B12 and Folic acid can anti-anemia action, be iron absorb indispensable material, root of herbaceous peony nourishing blood for regulating menstruation, sallow for the deficiency of blood, Dispel rheumatism, tonify the liver and kidney, China rose promoting blood circulation for regulating menstruation, soothing liver-qi stagnation, saline cistanche kidney-replenishing, benefiting essence-blood, Erigeron breviscapus is invigorated blood circulation inducing meastruation to relieve menalgia, rhodiola root qi and activate blood circulation, promotes blood circulation and relievings asthma, and Fructus Hordei Germinatus promoting the circulation of qi helps digestion, invigorating the spleen Appetizing, Gorgon fruit supplementing the kidney to control the nocturnal, tonifying spleen and stopping diarrhea, Colla Corii Asini nourishing blood enriching yin, moisturize hemostasis, threeleaf loosestrife herb dispels the wind logical Network, the promoting flow of qi and blood circulation, szechwan-Yunnan sanicle root tonifies the lung to relieve cough, and kidney-nourishing nourishes heart, Chinese holly leaf liver and kidney benefiting, wines used as antirheumatic, cynomorium songaricum Tonifying kidney and strengthening yang, benefiting essence-blood, Semen sesami nigrum filling liver kidney, support essence and blood, all medicines share, and invigorating the spleen helps fortune, are in harmonious proportion stomach and intestine, Qi-supplementing, blood-engendering, and mild in medicine property and, mouthfeel is suitable.
Further, described Chinese medicine composition only has above-mentioned raw materials medicine composition.
In described Chinese medicine composition the weight of each raw material be respectively American Ginseng 45 weight portion～55 weight portions, The bighead atractylodes rhizome 30 weight portion～40 weight portions, date 60 weight portion～70 weight portions, prepared rhizome of rehmannia 80 weight portion～ 90 weight portions, arillus longan 35 weight portion～45 weight portions, radix bupleuri 30 weight portion～40 weight portions, Chinese holly Matrimony vine 50 weight portion～60 weight portions, the fleece-flower root 80 weight portion～90 weight portions, Radix Angelicae Sinensis 60 weight portion～ 70 weight portions, the root of herbaceous peony 50 weight portion～60 weight portions, cortex acanthopanacis 35 weight portion～45 weight portions, the moon Spend 20 weight portions～30 weight portions, saline cistanche 55 weight portion～65 weight portions, erigeron breviscapus 15 weight season Amount part～25 weight portions, rhodiola root 20 weight portion～30 weight portions, szechwan-Yunnan sanicle root 30 weight portion～40 weights Amount part, Fructus Hordei Germinatus 55 weight portion～65 weight portions, Gorgon fruit 45 weight portion～55 weight portions, donkey-hide gelatin 110 Weight portion～120 weight portions, threeleaf loosestrife herb 35 weight portion～45 weight portions, Chinese holly leaf 20 weight portion～30 Weight portion, cynomorium songaricum 20 weight portion～30 weight portions and Semen sesami nigrum 50 weight portion～60 weight portions.
Further, the weight portion of each raw material more preferably American Ginseng 50 weight in described Chinese medicine composition Part～55 weight portions, the bighead atractylodes rhizome 35 weight portion～40 weight portions, date 65 weight portion～70 weight portions, Prepared rhizome of rehmannia 85 weight portion～90 weight portions, arillus longan 40 weight portion～45 weight portions, radix bupleuri 30 weight Part～35 weight portions, the fruit of Chinese wolfberry 55 weight portion～60 weight portions, the fleece-flower root 85 weight portion～90 weight Part, Radix Angelicae Sinensis 65 weight portion～70 weight portions, the root of herbaceous peony 55 weight portion～60 weight portions, cortex acanthopanacis 35 weight Amount part～40 weight portions, China rose 20 weight portion～25 weight portions, saline cistanche 60 weight portion～65 weights Amount part, erigeron breviscapus 15 weight portion～20 weight portions, rhodiola root 20 weight portion～25 weight portions, little black Medicine 30 weight portion～35 weight portions, Fructus Hordei Germinatus 55 weight portion～60 weight portions, Gorgon fruit 45 weight portion～50 Weight portion, donkey-hide gelatin 115 weight portion～120 weight portions, threeleaf loosestrife herb 35 weight portion～40 weight portions, contribution Leaf 20 weight portion～25 weight portions, cynomorium songaricum 20 weight portion～25 weight portions and Semen sesami nigrum 55 weight portion～ 60 weight portions.
Further, the weight portion of each raw material more preferably American Ginseng 50 weight in described Chinese medicine composition Part, the bighead atractylodes rhizome 35 weight portion, date 65 weight portion, prepared rhizome of rehmannia 85 weight portion, arillus longan 40 weight portion, Radix bupleuri 35 weight portion, the fruit of Chinese wolfberry 55 weight portion, the fleece-flower root 85 weight portion, Radix Angelicae Sinensis 65 weight portion, white Chinese herbaceous peony 55 weight portion, cortex acanthopanacis 40 weight portion, China rose 25 weight portion, saline cistanche 60 weight portion, lamp Small cup the root of Chinese wild ginger 20 weight portion, rhodiola root 25 weight portion, szechwan-Yunnan sanicle root 35 weight portion, Fructus Hordei Germinatus 60 weight portion, Gorgon fruit 50 weight portion, donkey-hide gelatin 115 weight portion, threeleaf loosestrife herb 40 weight portion, Chinese holly leaf 25 weight portion, lock Sun 25 weight portions and Semen sesami nigrum 55 weight portion.
In described Chinese medicine composition, each raw material pharmacology is as follows:
American Ginseng: taste hardship sweet, micro-, cool in nature, the thoughts of returning home, lung, kidney channel, there is boosting qi and nourishing yin, heat-clearing is raw The effect in Tianjin, cures mainly deficiency of vital energy yin deficiency, interior heat, coughs and breathe heavily phlegm blood, and abnormal heat is tired of tired, quenches one's thirst, dryness of the mouth and throat.
The bighead atractylodes rhizome: taste is sweet, bitter, warm in nature, enters spleen, stomach warp, has tonifying spleen profit gas, eliminating dampness Li Shui, Gu table is only Sweat, the fortune effect moisturized of spleen, it is mainly used in the caused ruffian of the dysfunction of the spleen in transport, QI failing to transform into body fluid and has one's mind filled with and rush down, phlegm and retained fluid Oedema；The vexed lazy speech of the deficiency of qi in middle-jiao, metrorrhagia and metrostaxis, proctoptosis with chronic dysentery；In the playing of deficiency of the spleen causing weakness of QI solid, Abnormal sweating spontaneous perspirations etc. are demonstrate,proved.
Date: taste is sweet, warm in nature, enter spleen, stomach warp, there is air making-up and spleen enlivening, nourishing blood and tranquilization, mediation Battalion defends, relaxes the effect of the property of medicine, and for weakness of the spleen and the stomach, fatigue and asthenia, anorexia and loose stool, qi and blood is not The cards such as foot, has a headache and fever, sweating hot blast.
Prepared rhizome of rehmannia: have another name called cultivated land, taste is sweet, slightly warm in nature, enters liver, kidney channel, has enriching yin of enriching blood, benefit essence Fill out the effect of marrow, sallow for the deficiency of blood；Dizziness, palpitaition, insomnia, irregular menstruation, collapses more than；Liver kidney Yin deficiency, night sweat, foot knee pain, soreness and weakness of waist and knees, Hiccough and deaf, the head is dim-sighted；Seminal emission impotence；Sterile Infertile；Irregular menstruation；Metrostaxis；Poliosis；Quench one's thirst；Constipation；Syndrome characterized by dyspnea etc. of suffering from a deficiency of the kidney is demonstrate,proved.
Arillus longan: warm in nature, taste is sweet, has tonifying heart and spleen, effect of nourishing blood and tranquilization, for insufficiency of vital energy and blood, The cards such as palpitation and severe palpitation, forgetful insomnia, the deficiency of blood are sallow.
Radix bupleuri: bitter, cold nature, return liver, gallbladder channel, there is evacuation and bring down a fever, rise effect of the easypro liver of sun, Curing mainly cold, fever, fevers and chills alternate, malaria, stagnation of QI due to depression of the liver, sternal rib pain, prolapse of the anus, uterus comes off, Irregular menstruation etc. are demonstrate,proved.
The fruit of Chinese wolfberry: taste is sweet, property is flat, enters liver, kidney channel, tonify the liver and kidney, nourish blood enrich blood, benefiting shrewd head, The effect moistened the lung and relieve the cough, is mainly used in liver and kidney deficiency, the soreness and weakness of waist and knees of asthenia of essence and blood, dizziness and tinnitus, something lost Essence tinnitus, unconsciously sweat and tire；The impotence of the insufficiency of the kidney yang, sterile；Deficiency of YIN-essence,impairment of YIN-essence, the eyes dusk of deficiency of liver-blood Flower and deficiency of Yin labor are coughed and are waited card, and the fruit of Chinese wolfberry can promote liver cell regeneration, enhancing non-specific immune function Effect.
The fleece-flower root: bitter, sweet, puckery, slightly warm in nature, return liver, kidney channel, there is nourishing the blood and yin, ease constipation is led to Just effect, cures mainly deficiency of blood Light-headedness；Palpitaition；Insomnia；The soreness and weakness of waist and knees of the deficiency of liver-yin and kidney-yin；Beard and hair is early In vain；Tinnitus；Seminal emission；The dry constipation of intestines；Chronic malaria body is empty；Rubella itch；Sore carbuncle；Scrofula；Hemorrhoid etc. are demonstrate,proved, The fleece-flower root can make telangiectasis.
Radix Angelicae Sinensis: latin name Angelicae Sinensis Radix, taste is sweet, pungent, warm in nature, enter liver, the heart, The spleen channel, has replenishing and activating blood, menstruction regulating and pain relieving, the effect relaxed bowel, and cures mainly the dizziness mesh of deficiency of heart-blood Dizzy, lassitude hypodynamia, palpitation, the sea of blood is hollow, the cold and deficiency of chong and ren channels or the irregular menstruation of extravasated blood retardance, warp Bitterly, producing or suffer from abdominal pain, and the constipation etc. that other blood stasis are had a pain and the few intestines of deficiency of Yin blood are dry is demonstrate,proved, it can improve uterus Blood circulation, alleviate pelvic congestion, alleviate dysmenorrhoea.
The root of herbaceous peony: bitter, acid, cold nature, enters liver, the spleen channel, joint venture of nourishing blood, and soft liver pain relieving is stabilized The effect of liver-yang, be mainly used in deficiecny of liver-YIN, liver-yang hyperactivity headache brain is swollen, dizziness tinnitus, irritated easily Anger；Deficiency of liver-blood, battalion defends the irregular menstruation of inanition, metrorrhagia and metrostaxis；The dysmenorrhoea of liver void stasis dampness；Battalion Defend discord, the cloudy outer spontaneous sweating more of battalion；The gastral cavity abdomen pain over the hypochondriac region of stagnation of liver qi, rushes down dysentery stomachache；Liver-yin Virtual loss, passages through which vital energy circulates loses the carpopedal spasm pain etc. supported and demonstrate,proves, has antithrombus formation and hepatoprotective effect, to dysentery bar Bacterium, typhoid bacillus, blood dissolubility streptococcus, Diplococcus pneumopniae, Pseudomonas aeruginosa, staphylococcus aureus have Inhibitory action, the root of herbaceous peony is share with prepared rhizome of rehmannia, enriches blood with nourishing yin and nourishing blood, treats the cards such as deficiency of blood dizziness.
Cortex acanthopanacis: taste is pungent, bitter, warm in nature, returns liver, kidney channel, has wines used as antirheumatic, filling liver kidney, strong muscle Bone, the effect of arteries and veins of invigorating blood circulation, for wind-cold-dampness arthralgia；Lumbocrural pain；Muscles and bones impotence is soft；Children's's retardation of walking； Body void is frail；Traumatic injury；Fracture；Oedema；Tinea pedis；Uncontrolled urination such as is itched at the card.
China rose: latin name Rosae Chinensis Flos, taste is sweet, warm in nature, returns Liver Channel, has and invigorates blood circulation Menstruation regulating, effect of soothing liver-qi stagnation, cure mainly qi depression to blood stasis, irregular menstruation, dysmenorrhoea, amenorrhoea, distending pain in the chest and hypochondrium Deng card.
Saline cistanche: taste is sweet, one-tenth, warm in nature, enters kidney, large intestine channel, has kidney-replenishing, benefiting essence-blood, and ease constipation is led to Just effect, for decline of kidney-YANG, the impotence and premature ejaculation of asthenia of essence and blood, infertile, soreness of waist and knee joint, ear Ring deafness, frequent micturition urine number, intestines of suffering from a deficiency of the kidney are dry and the card such as the deficiency of blood in postpartum, the constipation that body fluid deficiency after being ill.
Erigeron breviscapus: taste hardship pungent, micro-, warm in nature, there is expelling cold and relieving exterior syndrome, dispel rheumatism, active pain relieving Effect, for cold headache, toothache, stomachache, rheumatalgia pain, the paralysis that cerebrovas-cularaccident causes, bone The cards such as marrow is scorching.
Rhodiola root: sweet, bitter, flat.Return lung, the heart channel of Hang-Shaoyin, there is qi and activate blood circulation, effect relievingd asthma of promoting blood circulation, For cards such as qi deficiency to blood stasis, chest impediment and cardialgia, hemiplegia, burnout asthma, rhodiola root can improve The content of protein in chicken.
Szechwan-Yunnan sanicle root: taste hardship sweet, micro-, property is flat, has and tonifies the lung to relieve cough, and effect that kidney-nourishing nourishes heart cures mainly labor The cards such as cough, void is coughed, lumbago due to the kidney deficiency, dizzy, palpitaition.
Fructus Hordei Germinatus: taste is sweet, property is flat, returns spleen, stomach warp, has promoting the circulation of qi and help digestion, spleen benefiting and stimulating the appetite, moves back breast dissipate-swelling Effect, cure mainly dyspepsia and do not disappear, abdominal distention and diarrhea rushes down, n and V, poor appetite, milk smoulders, breast Distending pains etc. are demonstrate,proved, and containing digestive ferment and B family vitamin in Fructus Hordei Germinatus, have hydrochloric acid in gastric juice and pepsic secretion Facilitation.
Gorgon fruit: taste is sweet, puckery, property is put down.Return spleen, kidney channel.There is supplementing the kidney to control the nocturnal, tonifying spleen and stopping diarrhea, clearing damp Only the function of band, cures mainly emission, splenasthenic diarrhea, insufficiency of the spleen gonorrhoea, carries inferior card.
Donkey-hide gelatin: taste is sweet, property is flat, enters lung, liver, kidney channel, tonifies the blood and arrest bleeding, nourshing Yin and drynsessmoistening prescription effect, Can be used for various consumptive disease symptom, the especially sallow complexion of the deficiency of blood, thin and weak weak, the head is dizzy, palpitaition Insomnia；Malnutritional anemia, thrombocytopenic purpura；Deficient property hemoptysis；Haematemesis hematuria is had blood in stool； The cough dry throat of the lung-dryness syndrome due to yin deficiency, blood-stained sputum；Pathogenic heat lingering, deficiency of Yin blood consumption, the muscle arteries and veins of endogenous deficient wind are arrested The symptoms such as urgency, tetany, donkey-hide gelatin has the erythrocytic generation of promotion, increases blood calcium concentration, only promotes The effect of blood, and contribute to strengthening the immunologic function of human body.
Threeleaf loosestrife herb: taste is pungent, bitter, warm in nature, the thoughts of returning home, lung channel, there is dispelling wind and removing obstruction in the meridians, the merit of the promoting flow of qi and blood circulation Effect, cures mainly the cards such as arthralgia due to wind-dampness, epigastric pain, treating swelling and pain by traumatic injury, cough due to consumptive disease.
Chinese holly leaf: bitter, cool in nature, return liver, kidney channel, there is clearind deficient heat, liver and kidney benefiting, the merit of wines used as antirheumatic The cards such as effect, cures mainly hectic fever due to yin deficiency, hemoptysis of coughing, and has a dizzy spell, soreness and weakness of waist and knees, arthralgia due to wind-dampness.
Cynomorium songaricum: taste is sweet, warm in nature, to return spleen, kidney, large intestine channel, there is kidney-replenishing, benefiting essence-blood, ease constipation is led to Just effect, cure mainly the insufficiency of the kidney yang, essence and blood void lose, impotence, infertile, soreness and weakness of waist and knees；The dry constipation of intestines etc. Card.
Semen sesami nigrum: taste is sweet, property is put down, is entered liver, kidney, large intestine channel, has filling liver kidney, benefiting essence-blood, profit The effect that intestines are dry, for dizzy, Hiccough and deaf, poliosis, post disease alopecia, intestines are dry just Secret grade is demonstrate,proved.
Present invention also offers the preparation method of above-mentioned Chinese medicine composition, particularly as follows:
The first step, the extraction of above-mentioned Chinese medicine composition；
Second step, the purifying of extract.
The described first step is specially and each raw material medicaments in part by weight in described Chinese medicine is mixed, and stirs, adds Enter relative to mixture quality 6～the water of 8 times, by the pH value of the hydrochloric acid regulation water that volumetric concentration is 5% be 2～3, to soak 1 hour～2 hours, decoct 3 hours～5 hours subsequently, decoction liquor filters, and filter residue is again Adding relative to mixture quality 4～the water of 6 times, decoct 3 hours～5 hours, decoction liquor filters, and will decoct Boil liquid to merge, be that 10% NaOH regulation pH value is to 6～7 by mass percentage concentration, it is thus achieved that extract, It is that at 50 DEG C, relative density is the lotion of 1.10～1.20 that extract concentrates, and is cooled to room temperature, adds dense Degree be 95% ethanol reach 60% to alcohol content, 0 DEG C refrigerate 12 hours, filter, filtrate decompression is dense Retracting and receive ethanol, being concentrated into relative density at 50 DEG C is the lotion of 1.10～1.20.
Described second step is specially the thick paste first step obtained and adds the large pore resin absorption column of D101 type On, first use the water of 1～2 times of column volume to rinse, be the second of 30% using 3～5 times of column volume determining alcohols Alcohol elutes, then to use 3～5 times of column volume determining alcohols be the ethanol elution of 70%, and collecting determining alcohol is 30% Ethanol eluate and determining alcohol be the ethanol eluate of 70%, being evaporated to relative density at 50 DEG C is 1.10～1.20, add isopyknic water, refrigerate 12 hours at 0 DEG C, filter, filtrate concentrates and removes solvent, Pulverize, be dried, it is thus achieved that Chinese medicine composition extraction purification thing.
The present invention provides a kind of blood-enriching oral liquid, and it includes promoting the Chinese drug-treated group that iron supplementary absorbs and enriches blood Compound, vitamin C, Cobastab2, brown sugar, iron supplementary and the water of She's amount, in described blood-enriching oral liquid The percentage by weight of each component is respectively described Chinese medicine composition 30%～40%, vitamin C 3%～5%, Cobastab23%～5%, brown sugar 10%～18%, iron supplementary 8%～12% and the water of She's amount.
Wherein, in described blood-enriching oral liquid health products, the percentage by weight of each component is described Chinese medicine composition 35%, vitamin C 4%, Cobastab24%, brown sugar 15%, iron supplementary 10% and the water of She's amount.
Further, described blood-enriching oral liquid health products are only made up of said components.
Further, the mass percent sum of the above-mentioned each component of described blood-enriching oral liquid health products is 100%.
Vitamin C: also known as ascorbic acid, the ferric iron back that it can make human body be difficult to absorb becomes two Valency iron, promotes the enteron aisle absorption to iron, improves the liver utilization rate to iron, contributes to treating iron-deficient lean Blood.Vitamin C can also help iron to transfer to ferritin from carrier transferrins.Additionally it also has enhancing The function of some iron enzyme activity.
Cobastab2: also referred to as riboflavin, is the important composition composition of many enzyme systems in body, if body Be deficient in vitamin B2, it may appear that matter and energy metabolic disorder.Cobastab2Also it is that composition is erythrocytic Important substance.Research proves, it has important effect to the absorption promoting iron.Have been reported title and lack dimension Raw element B2Pregnant woman be susceptible to hypoferric anemia.Therefore appropriate vitamin B2Picked-up to prevention pregnant woman Hypoferric anemia is highly profitable.
Brown sugar: sweet, gentle, nontoxic, enters liver, spleen.Can be used for moistening cardiopulmonary, and in help spleen, slow Irritability, enriches blood, the broken stasis of blood.
Described iron supplementary be Ferric Sodium Edetate, iron-dextrin, ferrous fumarate, ferrous lactate, One or more mixing in ironic citrate or PORPHYRIN IRON, preferably PORPHYRIN IRON, utilize biology to extract and divide From means extract from animal blood to PORPHYRIN IRON be a kind of biologically active heme iron, relative to inorganic Iron or Organic Iron, PORPHYRIN IRON directly can quickly be absorbed by intestinal epithelial cell and be combined with hemoglobin, ginseng Process with hemoglobin transport oxygen.
Present invention also offers the preparation method of this blood-enriching oral liquid, particularly as follows:
The first step, prepares Chinese medicine composition according to the method described above；
Second step, being dissolved in distilled water by 25g NaOH and being prepared as mass percentage concentration is 10% Soda bath, is then slowly added to 50g PORPHYRIN IRON, and stirring is to being completely dissolved, it is thus achieved that solution；
3rd step, by 75g brown sugar, 20g vitamin C, 20g Cobastab2Prepare with the 175g first step Chinese medicine composition be slowly added in the solution that second step obtains, stirring completely, solution ph regulated value 6～8, refrigerate 12 hours at 0 DEG C, filter, with distilled water diluting to 500ml, 60～80 DEG C of hot embeddings, 121 DEG C of autoclavings, lamp inspection, inspection, packaging.
Hereinafter use embodiment to describe embodiments of the present invention in detail, whereby how the present invention is applied Technological means solves technical problem, and the process that realizes reaching technique effect can fully understand and real according to this Execute.
Embodiment 1 Chinese medicine composition 1
By American Ginseng 50g, bighead atractylodes rhizome 35g, date 65g, prepared rhizome of rehmannia 85g, arillus longan 40g, radix bupleuri 35g, Fruit of Chinese wolfberry 55g, fleece-flower root 85g, Radix Angelicae Sinensis 65g, root of herbaceous peony 55g, cortex acanthopanacis 40g, China rose 25g, meat Desert cistanche 60g, erigeron breviscapus 20g, rhodiola root 25g, szechwan-Yunnan sanicle root 35g, Fructus Hordei Germinatus 60g, Gorgon fruit 50g, Ah Glue 115g, threeleaf loosestrife herb 40g, Chinese holly leaf 25g, cynomorium songaricum 25g and Semen sesami nigrum 55g mixing, stir, Add the water of 8kg, be 3 by the pH value of the hydrochloric acid regulation water that volumetric concentration is 5%, soak 1 hour～2 Hour, decocting 5 hours subsequently, decoction liquor filters, and filter residue adds the water of 6kg again, decocts 5 hours, Decoction liquor filters, and decoction liquor is merged, and is that 10% NaOH regulates pH value extremely by mass percentage concentration 7, it is thus achieved that extract, it is that at 50 DEG C, relative density is the lotion of 1.20 that extract concentrates, and is cooled to room temperature, Add the ethanol that concentration is 95% and reach 60% to alcohol content, refrigerate 12 hours at 0 DEG C, filter, filter Liquid reduced pressure concentration reclaims ethanol, and being concentrated into relative density at 50 DEG C is the lotion of 1.20, the thick paste that will obtain Add on the large pore resin absorption column of D101 type, first use the water of 2 times of column volumes to rinse, using 5 Times column volume determining alcohol is the ethanol elution of 30%, then to use 5 times of column volume determining alcohols be the ethanol of 70% Wash-out, collect determining alcohol be 30% ethanol eluate and determining alcohol be the ethanol eluate of 70%, decompression Being concentrated into relative density at 50 DEG C is 1.20, adds isopyknic water, refrigerates 12 hours at 0 DEG C, filters, Filtrate concentrates and removes solvent, pulverizes, and is dried, it is thus achieved that Chinese medicine composition 1.
Embodiment 2 Chinese medicine composition 2
By American Ginseng 55g, bighead atractylodes rhizome 40g, date 70g, prepared rhizome of rehmannia 90g, arillus longan 45g, radix bupleuri 35g, Fruit of Chinese wolfberry 60g, fleece-flower root 90g, Radix Angelicae Sinensis 70g, root of herbaceous peony 60g, cortex acanthopanacis 40g, China rose 25g, meat Desert cistanche 65g, erigeron breviscapus 20g, rhodiola root 25g, szechwan-Yunnan sanicle root 35g, Fructus Hordei Germinatus 60g, Gorgon fruit 50g, Ah Glue 120g, threeleaf loosestrife herb 40g, Chinese holly leaf 25g, cynomorium songaricum 25g and Semen sesami nigrum 60g mixing, stir, Add the water of 8.5kg, be 3 by the pH value of the hydrochloric acid regulation water that volumetric concentration is 5%, soak 1 hour ～2 hours, decocting 4 hours subsequently, decoction liquor filters, and filter residue adds the water of 6.5kg again, decocts 4 Hour, decoction liquor filters, and decoction liquor is merged, and is 10% NaOH regulation pH by mass percentage concentration Value is to 7, it is thus achieved that extract, and it is that at 50 DEG C, relative density is the lotion of 1.20 that extract concentrates, and is cooled to Room temperature, adds the ethanol that concentration is 95% and reaches 60% to alcohol content, refrigerates 12 hours at 0 DEG C, mistake Filter, filtrate reduced in volume reclaims ethanol, and being concentrated into relative density at 50 DEG C is the lotion of 1.20, will obtain Thick paste add D101 type large pore resin absorption column on, first use 2 times of column volumes water rinse, Using 5 times of column volume determining alcohols is the ethanol elution of 30%, then to use 5 times of column volume determining alcohols be 70% Ethanol elution, collect determining alcohol be 30% ethanol eluate and determining alcohol be the ethanol eluate of 70%, Being evaporated to relative density at 50 DEG C is 1.20, adds isopyknic water, refrigerates 12 hours at 0 DEG C, Filtering, filtrate concentrates and removes solvent, pulverizes, and is dried, it is thus achieved that Chinese medicine composition 2.
Embodiment 3
By American Ginseng 50g, bighead atractylodes rhizome 35g, date 65g, prepared rhizome of rehmannia 85g, arillus longan 40g, radix bupleuri 30g, Fruit of Chinese wolfberry 55g, fleece-flower root 85g, Radix Angelicae Sinensis 65g, root of herbaceous peony 55g, cortex acanthopanacis 35g, China rose 20g, meat Desert cistanche 60g, erigeron breviscapus 15g, rhodiola root 20g, szechwan-Yunnan sanicle root 30g, Fructus Hordei Germinatus 55g, Gorgon fruit 45g, Ah Glue 115g, threeleaf loosestrife herb 35g, Chinese holly leaf 20g, cynomorium songaricum 20g and Semen sesami nigrum 55g mixing, stir, Add the water of 7.5kg, be 3 by the pH value of the hydrochloric acid regulation water that volumetric concentration is 5%, soak 1 hour ～2 hours, decocting 4 hours subsequently, decoction liquor filters, and filter residue adds the water of 5.5kg again, decocts 4 Hour, decoction liquor filters, and decoction liquor is merged, and is 10% NaOH regulation pH by mass percentage concentration Value is to 7, it is thus achieved that extract, and it is that at 50 DEG C, relative density is the lotion of 1.20 that extract concentrates, and is cooled to Room temperature, adds the ethanol that concentration is 95% and reaches 60% to alcohol content, refrigerates 12 hours at 0 DEG C, mistake Filter, filtrate reduced in volume reclaims ethanol, and being concentrated into relative density at 50 DEG C is the lotion of 1.20, will obtain Thick paste add D101 type large pore resin absorption column on, first use 2 times of column volumes water rinse, Using 5 times of column volume determining alcohols is the ethanol elution of 30%, then to use 5 times of column volume determining alcohols be 70% Ethanol elution, collect determining alcohol be 30% ethanol eluate and determining alcohol be the ethanol eluate of 70%, Being evaporated to relative density at 50 DEG C is 1.20, adds isopyknic water, refrigerates 12 hours at 0 DEG C, Filtering, filtrate concentrates and removes solvent, pulverizes, and is dried, it is thus achieved that Chinese medicine composition 3.
Embodiment 4 blood-enriching oral liquid 1
25g NaOH is dissolved in distilled water that to be prepared as the caustic soda that mass percentage concentration is 10% molten Liquid, is then slowly added to 50g PORPHYRIN IRON (offer of Hui Kang source, Beijing bio tech ltd), and stirring is extremely It is completely dissolved, it is thus achieved that solution, 75g brown sugar, 20g vitamin C, 20g vitamin B2 and 175g is real The Chinese medicine composition 1 executing example 1 preparation is slowly added in previously obtained solution, and stirring is complete, pH value of solution Value regulated value 7, refrigerates 12 hours at 0 DEG C, filters, and with distilled water diluting to 500ml, 70 DEG C of heat fill Envelope, 121 DEG C of autoclavings, lamp inspection, inspection, packaging.
Embodiment 5 blood-enriching oral liquid 2
25g NaOH is dissolved in distilled water that to be prepared as the caustic soda that mass percentage concentration is 10% molten Liquid, is then slowly added to 50g PORPHYRIN IRON (offer of Hui Kang source, Beijing bio tech ltd), and stirring is extremely It is completely dissolved, it is thus achieved that solution, by 75g brown sugar, 20g vitamin C, 20g Cobastab2Real with 175g The Chinese medicine composition 2 executing example 2 preparation is slowly added in previously obtained solution, and stirring is complete, pH value of solution Value regulated value 7, refrigerates 12 hours at 0 DEG C, filters, and with distilled water diluting to 500ml, 70 DEG C of heat fill Envelope, 121 DEG C of autoclavings, lamp inspection, inspection, packaging.
Embodiment 6 blood-enriching oral liquid 3
25g NaOH is dissolved in distilled water that to be prepared as the caustic soda that mass percentage concentration is 10% molten Liquid, is then slowly added to 50g PORPHYRIN IRON (offer of Hui Kang source, Beijing bio tech ltd), and stirring is extremely It is completely dissolved, it is thus achieved that solution, by 75g brown sugar, 20g vitamin C, 20g Cobastab2Real with 175g The Chinese medicine composition 3 executing example 3 preparation is slowly added in previously obtained solution, and stirring is complete, pH value of solution Value regulated value 7, refrigerates 12 hours at 0 DEG C, filters, and with distilled water diluting to 500ml, 70 DEG C of heat fill Envelope, 121 DEG C of autoclavings, lamp inspection, inspection, packaging.
The pharmacology test of embodiment 7 Chinese medicine composition
Acute toxicity test
Choose 30 kunming mices, Qingdao City animal used as test and animal experimental center provide, be divided into three groups, Be respectively Chinese medicine composition 1 group, Chinese medicine composition 2 groups and Chinese medicine composition 3 groups, oral administration gavage this The Chinese medicine composition of bright embodiment 1 to embodiment 3 preparation, is dissolved in Chinese medicine composition in distilled water Gavage, under 750g crude drug/kg dosage, after administration, mouse occurs that light activity reduces, about 1 hour Recover normal, Continuous Observation 7 days after administration, none animal dead, its overall health of patients, diet, take the photograph water, Urine and body weight increase all normal, test result indicate that: the Chinese medicine composition of the Mouse oral gavage present invention Maximum dosage-feeding be 750g crude drug/kg/d (LD50 > 750g crude drug/kg).The blood-enriching oral liquid of the present invention Every consumption per day of middle Chinese medicine composition is 0.3g crude drug/kg/d；By batheroom scale, in the mouse stomach present invention The dosis tolerata of drug composition is 2500 times of clinical patient.Pointing out this medicine acute toxicity low, clinical application is pacified Entirely.
Long term toxicity test
Select 30 SD rats, Qingdao City animal used as test and animal experimental center provide, be divided into three groups, Give the Chinese traditional medicine composition of embodiments of the invention 1 preparation of variable concentrations (54.0,27.0,9.0g crude drug/kg) Thing, is dissolved in gavage in distilled water by Chinese medicine composition, every day gavage once, continuous 90 days, last was given Within after medicine 24 hours, respectively group is alive kills 1/2 animal (male and female half and half), and remaining 1/2 animal lives after continuing to observe 2 weeks Kill.The outward appearance of animal, general behavior, food ration, changes of weight is observed, after administration 90 during test It and drug withdrawal carry out hematology (RBC, HB, granulophilocyte, PLT, CT, WBC and classification) for 2 weeks With blood biochemical (AST, ALT, ALP, Glu, BUN, Crea, TP, T.BIL, ALB, CHOL), The index checkings such as urine biochemistry, organ coefficient, Histopathology.Result of the test shows: in the present invention Medicine preparation is good at high, medium and low dosage treated animal general state, outward appearance sign, behavioral activity, feed Amount and body weight increase change the most without exception；Three dosage groups and control group hematological examination, blood biochemical analysis, Urine biochemical analysis all between normal range (NR), group without significant difference；Each group main organs histopathology inspection Look into and show no obvious abnormalities.These parameters drug withdrawal also had no change after 2 weeks.This test dosage is respectively The 180 of clinical medicine dose, 90,30 times, according to the Chinese medicine preparation of the result of the test present invention high, in, Low three dosage (54.0,27.0,9.0g crude drug/kg) are administered and have no significant effect rat for continuous 90 days, nothing Clear and definite toxicity target organ and sensitive indicator, convalescence observation also has no retardance toxic reaction, and prompting is originally The dose safety of the Chinese medicine preparation clinical practice of invention is higher.
Embodiment 8 zoopery
Laboratory apparatus
Atomic absorption spectrophotometer (Spect r AA-20 type), F4000 sepectrophotofluorometer (Japan Hitachi), Hb1002 hemoglobin determinator (Shanghai Yue Hai Huimin scientific instrument Co., Ltd), F T-630 γ-counter (Beijing Nuclear medical instruments factory)；(Abbott Laboratories of the U.S. are public for 3700 full-automatic blood counting instruments Department).
Reagent
The oral liquid 1 of the embodiment of the present invention 4 preparation, the potassium ferricyanide, ethyl acetate, diatomite, chlorination Sodium (Guangzhou chemical reagent work)；Acetic acid heparin (Tianjin Hao Nian medical product Co., Ltd)；Serum ferritin is with total Iron-binding capacity kit (Beijing Zhong Sheng Bioisystech Co., Ltd)；Low iron feed (Shandong Province's prevention from suffering from the diseases Control centre laboratory).
Animal used as test
80 SPF level SD rats, body weight 70～90g, by Qingdao City animal used as test and zoopery Center provides.
Set up Anemia model
After 80 SD rats are placed in laboratory environment adaptation 5d, 20 are only given normal rat basis raises Material and normal drinking water, as blank group, remaining 60 is only given low iron feed and drinks deionized water, Adopt tail blood examination after 20d and survey hemoglobin (Hb), by Hb less than 100g L-1Rat as iron deficiency Property Anemia model animal.
Before modeling, there was no significant difference with being fed with low iron feed group original body mass to be fed with conventional feed group.Make After mould 7d, model group Mouse Weight is substantially less than blank group, illustrates that model group mouse growth to be slower than Normal group mouse.Observing during modeling, and blank group ratio, model group mouse is in test the 10d starts ochrodermia occur, rough coat, sparse, and along with test period extends above-mentioned symptom more Add substantially, lean body mass, hair color tarnishes, and ear, claw all occur the palest, shows burnout, Movable minimizing, slow in reacting, like the group of shortening into.Its performance reduces with iron, and anaemia gradually increases the weight of, and causes Neural relevant with the disorders of digestion.
Experimental technique and observation index
Anemia in Rats is randomly divided into model group (20), positive controls (20) and enriches blood oral Liquid group (20).During experiment each treated animal continue to be fed with low iron feed and drink deionized water (gavage to Give 10mL kg-1Deionized water), blood-enriching oral liquid group gives blood-enriching oral liquid 2.0ml kg-1(quite In human body recommended amounts every day 5 times), and positive controls separately gives ferrous sulfate 2.0mg kg-1, Continuously 30d, measure hemoglobin (Hb), red blood cell number (RBC), packed cell volume (HC T), Iron content in Erythrocyte chemokine recepter (F EP), liver, spleen tissue.
Biochemical Indexes
Hemoglobin (Hb)
Use HemoCue to measure content of hemoglobin, take big rat-tail blood with 10 μ l quantitative capillary tubes, Put in the plastic tube filling 2.5ml high-potassium ferricyanide reagent, fully vibrate, make the complete dissolution of blood, keep away After light places 15min, measure with Hemoglobin Meter, measure hemoglobin standard and primary standard substance simultaneously.
Packed cell volume (HCT)
Take blood with 9 μ l quantitative capillary tubes, one end plasticine is sealed, use hematocrit measurement Instrument measures, and reads result, measure reference data blood sample simultaneously after 2min.
Red blood cell number (RBC)
Measure with full-automatic blood counting instrument.
Free erythrocyte protoporphyrin (F EP)
By droplets of whole blood on special filter paper, to be dried after be stored in 4 DEG C of refrigerators standby (time be less than 2 Month).During mensuration, with card punch, the filter paper with drop of blood is squeezed in teat glass, add 2% diatom Soil solution, puts into 4 DEG C of refrigerator overnight wash-outs, adds ethyl acetate: glacial acetic acid (4: 1) mixed liquor extracts Taking, centrifugal 10min, take supernatant and add 0.5mol/L hydrochloric acid, vibration is centrifugal, takes off layer liquid and uses Fluorescent spectrophotometer assay.
Iron content in liver, spleen tissue
After off-test, take about 0.2g tissue and put in the teat glass of hydrochloric acid dry cleansing, add Nitric acid: perchloric acid (4: 1) mixed acid 2ml, after digestion, is settled to 5ml or 10ml by deionized water, Use flame atomization to measure iron content in tissue, measure with beef liver powder (NBS every time NBS1577a) as Quality Control material.
Statistical procedures
Use SPSS10.0 statistical software experimental data is carried out variance analysis, result withRepresent.
Result
The blood-enriching oral liquid impact on Induced By Iron Deficiency Anemia In Rats hemoglobin, the results are shown in Table 1.
Table 1 changes before and after respectively organizing the experiment of Induced By Iron Deficiency Anemia In Rats hemoglobin
Compare with model group:*P<0.01；Compare with blank group:#P<0.01
As it can be seen from table 1 before Shi Yan, model group, positive controls, blood-enriching oral liquid group rat Hemoglobin and blank group have significant difference, P < 0.01, after experiment, and the blood of blood-enriching oral liquid group Before red eggs white value is significantly higher than experiment, and higher than positive controls and model group, show that blood-enriching oral liquid can It is obviously improved the Hemoglobin Value of rat.
The blood-enriching oral liquid impact on Induced By Iron Deficiency Anemia In Rats RBC, HCT, the results are shown in Table 2.
Table 2 changes before and after respectively organizing Induced By Iron Deficiency Anemia In Rats RBC, HCT experiment
Compare with model group:*P<0.01；Compare with blank group:#P<0.01
From table 2 it can be seen that before Shi Yan, model group, positive controls, blood-enriching oral liquid group red carefully Born of the same parents' number and packed cell volume value and blank group have significant difference, P < 0.01, after experiment, and mouth of enriching blood Take the red blood cell number of liquid group and before packed cell volume value is significantly higher than experiment, and higher than positive controls and mould Type group, shows that blood-enriching oral liquid has, to red blood cell number and the packed cell volume value of rat, the effect of remarkably promoting.
The blood-enriching oral liquid impact on Induced By Iron Deficiency Anemia In Rats F EP, the results are shown in Table 3.
Table 3 changes before and after respectively organizing Induced By Iron Deficiency Anemia In Rats F EP experiment
Compare with model group:*P<0.01；Compare with blank group:#P<0.01
From table 3 it can be seen that before Shi Yan, model group, positive controls, blood-enriching oral liquid group red carefully Dissociate protoporphyrin content and blank group of born of the same parents has significant difference, P < 0.01, after experiment, enriches blood oral Before the free erythrocyte protoporphyrin content of liquid group is significantly higher than experiment, and higher than positive controls and model group, Show that blood-enriching oral liquid has, to the free erythrocyte protoporphyrin content of rat, the effect of significantly reducing.
Blood-enriching oral liquid is on the impact of iron content in Induced By Iron Deficiency Anemia In Rats liver and spleen tissue, and result is shown in Table 4 and table 5.
Iron content in liver organization respectively organized by table 4
Compared with model group,*P<0.05
Iron content in spleen tissue respectively organized by table 5
Compared with model group,*P<0.05
From table 4 and table 5 it can be seen that each liver organizing rat and spleen weight difference are without statistics before Shi Yan Learn meaning (P > 0.05), after experiment, iron content and total in the rat liver of blood-enriching oral liquid group and spleen Iron content is all remarkably higher than model group, and higher than positive controls.
Knowable to data above, the Chinese medicine composition blood-enriching oral liquid that the present invention provides has and improves rat The effect of hypoferric anemia.
Embodiment 9 clinical data
173 examples are selected to be diagnosed as hypoferric anemia through health check-up and obtain the patient of informed consent and this time treat Effect is observed.It is randomly divided into treatment group 100 example, the maleest 53 examples, female 47 example；Age 20～72 years old, Control group totally 73 example, the wherein male sex 40 example, women 33 example, age 23～69 years old.All patients Hb level is below 120g/L, meets the diagnostic criteria about anaemia in WHO.Two groups of patients' is average Age, M-F, the clinical data aspect no significant difference such as state of an illness, there is comparativity.
Methods for the treatment of
Take merely Ferroids (ferrous sulfate controlled release tablet, Guangzhou matt Xinghua pharmaceutical factory produce, 0.2g/ time, Three times a day, 2 weeks it are serve on.After, Anemia normal until Hemoglobin Value is corrected, by 2mg/kg, often Week is administered orally for 1 time, serve on 10 weeks.Coordinate folic acid, vitamin C, pepsin mixture etc. simultaneously.There is infection disease Shape person adds anti-infectious agent, the person's expelling parasite that has parasitosis.
Treatment group is administered orally the blood-enriching oral liquid of the embodiment of the present invention 4 preparation, and morning, noon and afternoon every day respectively take 1 time, 15ml, serve on 2 weeks, treats that Anemia is corrected every time, after hemoglobin is normal, and following the service more than 8 weeks, Consolidate curative effect.
Criterion of therapeutical effect
Cure: clinical symptoms are obviously improved.The male sex: Hb > 120g/L, RBC > 4 × 1012/ L.Women: Hb > 110g/L, RBC > 3.5 × 1012/ L.Take a turn for the better: in 8 weeks, Hb at least rises 20g/L before relatively treating. Invalid: not reach above-mentioned standard.
Statistical procedures
Use SPSS10.0 statistical software experimental data is carried out variance analysis, result withRepresent.
Two groups of results for the treatment of compare, and the results are shown in Table 6.
6 liang of table group result for the treatment of compares
Group Number of cases Cure Take a turn for the better Invalid Efficient (%)
Treatment group 100 87 10 3 97%
Control group 73 32 26 15 79.5%
As can be seen from Table 6, the Chinese medicine composition blood-enriching oral liquid of the present invention is used can to significantly improve patient The situation of hypoferric anemia.
Two groups of anaemia experimental index are observed, and the results are shown in Table 7.
7 liang of table group anaemia experimental index is observed
Compare with before treatment:*P<0.05
As can be seen from Table 7, the Chinese medicine composition blood-enriching oral liquid of the present invention is used can to significantly improve anaemia Lab index RBC, Hb, HCT.
Two groups of adverse reactions of patients situation occurreds compare, and the results are shown in Table 8.
8 liang of table group infant bad reaction situation occurred compares
Group Number of cases Poor appetite N and V Epigastric discomfort Diarrhoea Fraction defective
Treatment group 100 1 0 3 2 6%
Control group 73 5 3 6 3 23.2%
As can be seen from Table 8, the Chinese medicine composition blood-enriching oral liquid bad reaction that the present invention provides is few, is A kind of well blood-tonifying health-care product.
All above-mentioned primary implement these intellectual properties, do not set limit other forms enforcement this Plant new product and/or new method.Those skilled in the art will utilize this important information, and foregoing is revised, To realize similar implementation status.But, all modifications or transformation belong to reservation based on new product of the present invention Right.
The above, be only presently preferred embodiments of the present invention, is not that the present invention makees other form Restriction, any those skilled in the art are changed possibly also with the technology contents of the disclosure above Or it is modified as the Equivalent embodiments of equivalent variations.But every without departing from technical solution of the present invention content, depend on Any simple modification, equivalent variations and remodeling above example made according to the technical spirit of the present invention, Still fall within the protection domain of technical solution of the present invention.

Claims (6)

1. one kind has the Chinese medicine composition promoting that ferrous components absorbs and enriches blood, it is characterised in that: the bulk drug of described Chinese medicine composition is made up of American Ginseng, the bighead atractylodes rhizome, date, prepared rhizome of rehmannia, arillus longan, radix bupleuri, the fruit of Chinese wolfberry, the fleece-flower root, Radix Angelicae Sinensis, the root of herbaceous peony, cortex acanthopanacis, China rose, saline cistanche, erigeron breviscapus, rhodiola root, szechwan-Yunnan sanicle root, Fructus Hordei Germinatus, Gorgon fruit, donkey-hide gelatin, threeleaf loosestrife herb, Chinese holly leaf, cynomorium songaricum and Semen sesami nigrum；
nullIn described Chinese medicine composition, the weight of each raw material is respectively American Ginseng 45 weight portion～55 weight portions、The bighead atractylodes rhizome 30 weight portion～40 weight portions、Date 60 weight portion～70 weight portions、Prepared rhizome of rehmannia 80 weight portion～90 weight portions、Arillus longan 35 weight portion～45 weight portions、Radix bupleuri 30 weight portion～40 weight portions、The fruit of Chinese wolfberry 50 weight portion～60 weight portions、The fleece-flower root 80 weight portion～90 weight portions、Radix Angelicae Sinensis 60 weight portion～70 weight portions、The root of herbaceous peony 50 weight portion～60 weight portions、Cortex acanthopanacis 35 weight portion～45 weight portions、China rose 20 weight portion～30 weight portions、Saline cistanche 55 weight portion～65 weight portions、Erigeron breviscapus 15 weight portion～25 weight portions、Rhodiola root 20 weight portion～30 weight portions、Szechwan-Yunnan sanicle root 30 weight portion～40 weight portions、Fructus Hordei Germinatus 55 weight portion～65 weight portions、Gorgon fruit 45 weight portion～55 weight portions、Donkey-hide gelatin 110 weight portion～120 weight portions、Threeleaf loosestrife herb 35 weight portion～45 weight portions、Chinese holly leaf 20 weight portion～30 weight portions、Cynomorium songaricum 20 weight portion～30 weight portions and Semen sesami nigrum 50 weight portion～60 weight portions.
2. Chinese medicine composition as claimed in claim 1, it is characterized in that: in described Chinese medicine composition, the weight portion of each raw material is American Ginseng 50 weight portion, the bighead atractylodes rhizome 35 weight portion, date 65 weight portion, prepared rhizome of rehmannia 85 weight portion, arillus longan 40 weight portion, radix bupleuri 35 weight portion, the fruit of Chinese wolfberry 55 weight portion, the fleece-flower root 85 weight portion, Radix Angelicae Sinensis 65 weight portion, the root of herbaceous peony 55 weight portion, cortex acanthopanacis 40 weight portion, China rose 25 weight portion, saline cistanche 60 weight portion, erigeron breviscapus 20 weight portion, rhodiola root 25 weight portion, szechwan-Yunnan sanicle root 35 weight portion, Fructus Hordei Germinatus 60 weight portion, Gorgon fruit 50 weight portion, donkey-hide gelatin 115 weight portion, threeleaf loosestrife herb 40 weight portion, Chinese holly leaf 25 weight portion, cynomorium songaricum 25 weight portion and Semen sesami nigrum 55 weight portion.
3. the preparation method of Chinese medicine composition described in claim 1 or 2, it is characterised in that:
The first step, the extraction of traditional Chinese medicinal composition raw materials described in claim 1 or 2；
Second step, the purifying of extract.
null4. the preparation method of Chinese medicine composition as claimed in claim 3，It is characterized in that: the described first step is specially and each raw material medicaments in part by weight in described Chinese medicine composition is mixed，Stir，Add the water relative to mixture quality 6 ~ 8 times，It is 2 ~ 3 by the pH value of the hydrochloric acid regulation water that volumetric concentration is 5%，Soak 1 hour ~ 2 hours，Decoct 3 hours ~ 5 hours subsequently，Decoction liquor filters，Filter residue adds the water relative to mixture quality 4 ~ 6 times again，Decoct 3 hours ~ 5 hours，Decoction liquor filters，Decoction liquor is merged，It is that 10% NaOH regulation pH value is to 6 ~ 7 by mass percentage concentration，Obtain extract，It is that at 50 DEG C, relative density is the lotion of 1.10 ~ 1.20 that extract concentrates，It is cooled to room temperature，Add the ethanol that concentration is 95% and reach 60% to alcohol content，Refrigerate 12 hours at 0 DEG C，Filter，Filtrate reduced in volume reclaims ethanol，Being concentrated into relative density at 50 DEG C is the lotion of 1.10 ~ 1.20.
5. blood-tonifying health-care product, it is characterised in that: by the Chinese medicine composition described in claim 1 or 2, vitamin C, Cobastab2, brown sugar, the water of iron supplementary and surplus is constituted；
In described blood-tonifying health-care product, the percentage by weight of each component is respectively described Chinese medicine composition 30% ~ 40%, vitamin C 3% ~ 5%, Cobastab23% ~ 5%, brown sugar 10% ~ 18%, iron supplementary 8% ~ 12% and the water of surplus.
6. blood-tonifying health-care product as claimed in claim 5, it is characterised in that: in described blood-tonifying health-care product, the percentage by weight of each component is described Chinese medicine composition 35%, vitamin C 4%, Cobastab24%, brown sugar 15%, iron supplementary 10% and the water of surplus.
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