CN102895519B

CN102895519B - Chinese medicine for treating allergic rhinitis and preparation method thereof

Info

Publication number: CN102895519B
Application number: CN201210417840.9A
Authority: CN
Inventors: 孙向红
Original assignee: 江志鑫
Current assignee: CHONGQING XUANNU BIOTECHNOLOGY CO., LTD.
Priority date: 2012-10-26
Filing date: 2012-10-26
Publication date: 2014-07-23
Anticipated expiration: 2032-10-26
Also published as: CN102895519A

Abstract

The invention provides a Chinese medicinal composition for treating allergic rhinitis. The Chinese medicinal composition comprises an internal medicament and an external medicament, wherein the internal medicament comprises the following components: astragalus, prepared tuber fleeceflower root, large-head atractylodes rhizome, magnolia flower, dahurian angelica root, cassia twig, small centipeda herb, kudzuvine root, dangshen, sealwort, dried orange peel, fingered citron, desertliving cistanche, milk vetch seed, yerbadetajo herb, indian buead, prepared common monkshood daughter root and cassia bark; and the external medicament comprises the following components: magnolia flower, dahurian angelica root, figwort, fructus gardenia, heartleaf houttuynia herb, tall gastrodia tuber, cicada shell, rhodiola rosea, turmeric root-tuber, long pepper, grassleaf sweelflag rhizome, immature bitter orange, common jasminorange leaf and twig, rehmannia root, common anemarrhena, coptis root and truestar anisetree. Compared with a Western medicine for treating allergic rhinitis, the Chinese medicinal composition has the advantages of short treatment course, good curative effect, small toxic and side effects and low recurrence rate.

Description

Be used for the treatment of Chinese medicine of allergic rhinitis and preparation method thereof

Technical field

The present invention relates to technical field of Chinese medicines, relate in particular to a kind of Chinese medicine that is used for the treatment of allergic rhinitis and preparation method thereof.

Background technology

Allergic rhinitis is allergic rhinitis, claim again allergic rhinitis, it is a kind of common allergic disease, because bronchia mucosal is experienced specific allergen (as oil smoke, pollen, chemicals etc.) stimulate the allergic symptom that produces, this disease prevalence worldwide about 15% ~ 20%, in China key city crowd, suffering from this sick ratio is 8% ~ 21.4%, morbidity is in recent years continuous ascendant trend, this disease is clinical in rhinocnesmus, the repeatedly raw sneeze of paroxysm, a large amount of water sample nasal mucus and nasal obstruction are cardinal symptom, this disease is clinical is divided into seasonality and perennial allergic rhinitis.Belong to I allergic reaction type, allergen presents multiformity.

From molecular immunology angle, allergic rhinitis are that external environmental factors acts on the abnormal immune reaction due to body.When after body contact allergen, the IgE antibodies on antigen-presenting cell and mastocyte surface, causes mast cell degranulation, release inflammatory reaction medium and occur allergy.What in allergic rhinitis production process, play the role of a nucleus is CD4+T cell, it by by Th0 cell to Th1, Th2 series cell differentiation, discharge different cytokines and regulate IgE secretion and affect allergic rhinitis and react; Th1/Th2 immunomodulating is unbalance is the main cause that causes the reaction of nasal membrane alterative inflammation.Th1 cell is mainly by secretion INF-γ, thereby the IgE's that inhibition IL-4 induces is synthetic.IL-12, mainly by secreting after macrophage phagocytic antigen, plays induction Th cell, natural killer cell secretion of gamma-IFN, activation NK cell and promotion, and Th0 cell is to the differentiation of Th1, and the effect of antagonism IL24 induction B cell generation IgE.Simultaneously, IFN-γ promotes Th1 cell differentiation, activating macrophage, and negative regulator Th2 cell and cytokine thereof are as IL-4, suppress mastocyte and eosinophilic granulocyte, and suppressing the effect of IL-4 to B cell itself, blocking-up B cell synthetic antibody molecule is to the classification conversion of IgE, therefore, western medical treatment mainly adopts immunotherapy, as glucocorticoid and antihistaminic etc., but often exist, the course for the treatment of is long, side effect is large, easy drawback repeatedly, and curative effect is not satisfactory.

Allergic rhinitis belongs to the traditional Chinese medical science " allergic rhinitis ", " allergic rhinitis with sneezing " category, and the traditional Chinese medical science thinks that the etiology and pathogenesis of its morbidity mostly is lung, spleen, renal dysfunction, and the exopathogenic factor evil institute of wind and cold causes.Insufficiency of lung-QI, instability of surface, the wind and cold lung qi of taking advantage of a weak point must not lead to tune, and body fluid stops poly-nose key and is jammed and then causes sneeze, snivel.And the substantial defeated cloth that depends on temper of lung qi, insufficiency of lung-QI of deficiency of spleen-QI; The root of gas, at kidney, is suffered from a deficiency of the kidney to take the photograph to receive and is had no right, and gas is not returned unit, invades pathogenic in ailment said due to cold or exposure is able to.Battalion defends imbalance, and the heresy invasion and attack of wind and cold, make lung meridian be subject to heresy, or dysfunction of the spleen in transportation, and clear YANG failing to ascend makes clearly key be disturbed by turbid yin, or because of insufficiency of kidney-YANG, and the mistake of lung spleen is warm and arrive and sneeze.

The nose being the orifice to the lung, lung governing qi leads in nose, and it is fluent with replenishing vital QI with drugs of warm nature nose key that lung qi a surname defends gas.The spleen being the foundation of acquired constitution, lung qi enriches, and depends on moistening of temper foster.If deficiency of both the splenic and pulmonary QI, does not precise and tinyly transport, nose must not replenishing vital QI with drugs of warm nature, weeps rare clearly, dripping and under, therefore treatment when taking invigorating the spleen and benefiting QI for will.The kidney being the origin of congenital constitution, and the root of gas is suffered from a deficiency of the kidney to take the photograph to receive and had no right, and gas is not returned unit, and yang-energy is easy to dissipate, and warm biochemical dereliction of duty is invaded in ailment said due to cold or exposure is able to and caused a disease.

According to theory of Chinese medical science, the present invention is with replenishing QI to invigorate the spleen, tonifying YANG consolidating superficial resistance, cold expelling is sensible is Therapeutic Principle, provides a kind of Chinese medicine composition that is used for the treatment of allergic rhinitis, with respect to the Western medicine for the treatment of of allergic rhinitis, this Chinese medicine composition has short treating period, curative effect is high, and toxic and side effects is little, the advantage that relapse rate is low.

Summary of the invention

Technical problem to be solved by this invention is, a kind of Chinese medicine composition that is used for the treatment of allergic rhinitis is provided, and with respect to the Western medicine for the treatment of of allergic rhinitis, this Chinese medicine composition has short treating period, and curative effect is high, and toxic and side effects is little, the advantage that relapse rate is low.

In order to solve the problems of the technologies described above, the invention provides a kind of novel Chinese medicine composition that is used for the treatment of allergic rhinitis, it comprises endo-medicine and external used medicine;

Described endo-medicine comprises following component, the Radix Astragali, Radix Polygoni Multiflori Preparata, the Rhizoma Atractylodis Macrocephalae, Flos Magnoliae, the Radix Angelicae Dahuricae, Ramulus Cinnamomi, Herba Centipedae, Radix Puerariae, Radix Codonopsis, Rhizoma Polygonati, Pericarpium Citri Reticulatae, Fructus Citri Sarcodactylis, Herba Cistanches, Semen Astragali Complanati, Herba Ecliptae, Poria, Radix Aconiti Lateralis Preparata, Cortex Cinnamomi;

Described external used medicine comprises following component Flos Magnoliae, the Radix Angelicae Dahuricae, Radix Scrophulariae, Fructus Gardeniae, Herba Houttuyniae, Rhizoma Gastrodiae, Periostracum Cicadae, Radix Rhodiolae, Radix Curcumae, Fructus Piperis Longi, Rhizoma Acori Graminei, Fructus Aurantii Immaturus, Folium Et Cacumen Murrayae, Rhizoma Phragmitis, the Rhizoma Anemarrhenae, Rhizoma Coptidis, Fructus Anisi Stellati.

Wherein, in described endo-medicine, the weight portion of each component is the Radix Astragali 35 ~ 45 weight portions, Radix Polygoni Multiflori Preparata 20 ~ 30 weight portions, the Rhizoma Atractylodis Macrocephalae 30 ~ 40 weight portions, Flos Magnoliae 45 ~ 55 weight portions, the Radix Angelicae Dahuricae 40 ~ 50 weight portions, Ramulus Cinnamomi 15 ~ 25 weight portions, Herba Centipedae 15 ~ 25 weight portions, Radix Puerariae 10 ~ 20 weight portions, Radix Codonopsis 60 ~ 70 weight portions, Rhizoma Polygonati 30 ~ 40 weight portions, Pericarpium Citri Reticulatae 15 ~ 25 weight portions, Fructus Citri Sarcodactylis 10 ~ 20 weight portions, Herba Cistanches 30 ~ 40 weight portions, Semen Astragali Complanati 25 ~ 35 weight portions, Herba Ecliptae 25 ~ 35 weight portions, Poria 10 ~ 20 weight portions, Radix Aconiti Lateralis Preparata 10 ~ 20 weight portions, Cortex Cinnamomi 10 ~ 20 weight portions,

In described external used medicine, the weight portion of each component is Flos Magnoliae 55 ~ 65 weight portions, the Radix Angelicae Dahuricae 35 ~ 45 weight portions, Radix Scrophulariae 15 ~ 25 weight portions, Fructus Gardeniae 20 ~ 30 weight portions, Herba Houttuyniae 15 ~ 25 weight portions, Rhizoma Gastrodiae 10 ~ 20 weight portions, Periostracum Cicadae 25 ~ 35 weight portions, Radix Rhodiolae 15 ~ 25 weight portions, Radix Curcumae 15 ~ 25 weight portions, Fructus Piperis Longi 15 ~ 25 weight portions, Rhizoma Acori Graminei 10 ~ 20 weight portions, Fructus Aurantii Immaturus 20 ~ 30 weight portions, Folium Et Cacumen Murrayae 15 ~ 25 weight portions, Rhizoma Phragmitis 25 ~ 35 weight portions, the Rhizoma Anemarrhenae 30 ~ 40 weight portions, Rhizoma Coptidis 35 ~ 45 weight portions, Fructus Anisi Stellati 10 ~ 20 weight portions.

Wherein, in described endo-medicine, the weight portion of each component is the Radix Astragali 40 ~ 45 weight portions, Radix Polygoni Multiflori Preparata 25 ~ 30 weight portions, the Rhizoma Atractylodis Macrocephalae 35 ~ 40 weight portions, Flos Magnoliae 50 ~ 55 weight portions, the Radix Angelicae Dahuricae 45 ~ 50 weight portions, Ramulus Cinnamomi 20 ~ 25 weight portions, Herba Centipedae 20 ~ 25 weight portions, Radix Puerariae 10 ~ 15 weight portions, Radix Codonopsis 65 ~ 70 weight portions, Rhizoma Polygonati 35 ~ 40 weight portions, Pericarpium Citri Reticulatae 20 ~ 25 weight portions, Fructus Citri Sarcodactylis 15 ~ 20 weight portions, Herba Cistanches 35 ~ 40 weight portions, Semen Astragali Complanati 30 ~ 35 weight portions, Herba Ecliptae 30 ~ 35 weight portions, Poria 10 ~ 15 weight portions, Radix Aconiti Lateralis Preparata 10 ~ 15 weight portions, Cortex Cinnamomi 10 ~ 15 weight portions,

In described external used medicine, the weight portion of each component is Flos Magnoliae 60 ~ 65 weight portions, the Radix Angelicae Dahuricae 40 ~ 45 weight portions, Radix Scrophulariae 15 ~ 20 weight portions, Fructus Gardeniae 25 ~ 30 weight portions, Herba Houttuyniae 15 ~ 20 weight portions, Rhizoma Gastrodiae 10 ~ 15 weight portions, Periostracum Cicadae 30 ~ 35 weight portions, Radix Rhodiolae 15 ~ 20 weight portions, Radix Curcumae 15 ~ 20 weight portions, Fructus Piperis Longi 15 ~ 20 weight portions, Rhizoma Acori Graminei 10 ~ 15 weight portions, Fructus Aurantii Immaturus 25 ~ 30 weight portions, Folium Et Cacumen Murrayae 20 ~ 25 weight portions, Rhizoma Phragmitis 30 ~ 35 weight portions, the Rhizoma Anemarrhenae 35 ~ 40 weight portions, Rhizoma Coptidis 40 ~ 45 weight portions, Fructus Anisi Stellati 10 ~ 15 weight portions.

Wherein, in described endo-medicine, the weight portion of each component is the Radix Astragali 40 weight portions, Radix Polygoni Multiflori Preparata 25 weight portions, the Rhizoma Atractylodis Macrocephalae 35 weight portions, Flos Magnoliae 50 weight portions, the Radix Angelicae Dahuricae 45 weight portions, Ramulus Cinnamomi 20 weight portions, Herba Centipedae 20 weight portions, Radix Puerariae 10 weight portions, Radix Codonopsis 65 weight portions, Rhizoma Polygonati 35 weight portions, Pericarpium Citri Reticulatae 20 weight portions, Fructus Citri Sarcodactylis 15 weight portions, Herba Cistanches 35 weight portions, Semen Astragali Complanati 30 weight portions, Herba Ecliptae 30 weight portions, Poria 10 weight portions, Radix Aconiti Lateralis Preparata 10 weight portions, Cortex Cinnamomi 10 weight portions;

In described external used medicine, the weight portion of each component is Flos Magnoliae 60 weight portions, the Radix Angelicae Dahuricae 40 weight portions, Radix Scrophulariae 15 weight portions, Fructus Gardeniae 25 weight portions, Herba Houttuyniae 15 weight portions, Rhizoma Gastrodiae 10 weight portions, Periostracum Cicadae 30 weight portions, Radix Rhodiolae 15 weight portions, Radix Curcumae 15 weight portions, Fructus Piperis Longi 15 weight portions, Rhizoma Acori Graminei 10 weight portions, Fructus Aurantii Immaturus 25 weight portions, Folium Et Cacumen Murrayae 20 weight portions, Rhizoma Phragmitis 30 weight portions, the Rhizoma Anemarrhenae 35 weight portions, Rhizoma Coptidis 40 weight portions, Fructus Anisi Stellati 10 weight portions.

Wherein, the dosage form of described endo-medicine is tablet, pin powder, capsule, hard capsule, soft capsule, oral liquid, granule, electuary, pill, powder, injection.

Wherein, the dosage form of described external used medicine is unguentum, spray, medical gauze, patch, smears agent or tincture.

The present invention also provides the preparation method of above-mentioned Chinese medicine composition, and in the time that the dosage form of described endo-medicine is powder, it comprises,

The first step, each component in described endo-medicine is all ground into 20 order ~ 30 object powder, putting in proportion blender is uniformly mixed, add the water with respect to 2 ~ 4 times of mixture qualities, decoct 3 ~ 5 hours, decoction liquor is filtered, obtain the first filtrate, add the water with respect to 2 ~ 4 times of filtering residue quality by filtering the filtering residue obtaining, again decoct 3 ~ 5 hours, decoction liquor is filtered, obtain the second filtrate, the first filtrate and the second filtrate are mixed to acquisition mixed liquor, concentrated except anhydrating, obtain concentrated solution, the volume of the concentrated solution after concentrated is 1/4 ~ 1/5 of concentrated front mixed liquor,

Second step, in concentrated solution, adding determining alcohol is that 80% ~ 90% ethanol is to reaching more than 80% containing alcohol amount, at 4 DEG C, cold preservation 24 hours, leaches precipitation, reclaims ethanol, concentrated, dry, obtain and get dry extract, put into super micron mill and pulverize, obtain 200 order ~ 300 object ultra-micro powders, be endo-medicine powder.

The present invention also provides the preparation method of above-mentioned Chinese medicine composition, and in the time that the dosage form of described endo-medicine is oral liquid, it comprises,

Second step, in concentrated solution, add determining alcohol be 80% ~ 90% ethanol to reaching more than 80% containing alcohol amount, cold preservation 24 hours at 4 DEG C, with the centrifugal rear acquisition supernatant of high speed centrifuge, add the A Siba of 0.01 ~ 0.03 times of mixture quality of the original components obtaining with respect to the first step sweet, the sucrose of 0.01 ~ 0.03 times, adds water to enough subsequently, stir, filter, embedding in 10ml oral liquid bottle, 100 DEG C of sterilizings 30 minutes, packaging, to obtain final product.

The present invention also provides the preparation method of above-mentioned Chinese medicine composition, and when the dosage form of described external used medicine is spray, it comprises,

The first step, each component in described external used medicine is all ground into 20 order ~ 30 object powder, putting in proportion blender is uniformly mixed, add the water with respect to 2 ~ 4 times of mixture qualities, decoct 3 ~ 5 hours, decoction liquor is filtered, obtain the first filtrate, add the water with respect to 2 ~ 4 times of filtering residue quality by filtering the filtering residue obtaining, again decoct 3 ~ 5 hours, decoction liquor is filtered, obtain the second filtrate, the first filtrate and the second filtrate are mixed to acquisition mixed liquor, concentrated except anhydrating, obtain concentrated solution, the volume of the concentrated solution after concentrated is 1/4 ~ 1/5 of concentrated front mixed liquor,

Second step, in concentrated solution, add determining alcohol be 80% ~ 90% ethanol to reaching more than 80% containing alcohol amount, cold preservation 24 hours, leaches precipitation at 4 DEG C, reclaim ethanol, concentrated, dry, obtain and get dry extract, put into super micron mill and pulverize, obtain 200 order ~ 300 object ultra-micro powders;

The 3rd step, the ultra-micro powder that second step is obtained is placed in the water with respect to 3 ~ 5 times of its quality, stirring and dissolving, to be dissolvedly add with respect to this solution quality 5% surfactant polyethylene 400 quantitative separatings in aerosol pressure vessel after completely, be pushed down into 2 times of volume propellant tetrafluoroethane in the condition of 100kPa again, make spray.

Beneficial effect of the present invention:

Chinese medicine composition provided by the invention is for treatment of allergic rhinitis, and with respect to Western medicine, this Chinese medicine composition has short treating period, and curative effect is high, and toxic and side effects is little, the advantage that relapse rate is low.

Detailed description of the invention

Allergic rhinitis belong to the categories such as " allergic rhinitis " in motherland's medical science, " allergic rhinitis with sneezing ", " water of having a stuffy nose ", and the clinical rhinocnesmus taking suddenly or repeatedly outbreak, sneeze are again and again, thin nasal discharge is if the disease such as water, nasal obstruction is as the cacorhinia of main manifestations.Allergic rhinitis with sneezing, the most on the books as far back as " the Book of Rites moon is cold " in the Western Zhou Dynasty: " season, The weather in autumn is as hot as in summer, Ze Qi state flood, the winter hides calamity and loses, the many allergic rhinitis with sneezing of the people ".Have a stuffy nose, see " the hexa-atomic large opinion of just recording of Plain Questions ", how more than former finger rhinorrhea with clear discharge, measure.Sneeze, see " Ling Shu Miraculous Pivot or Divine Axis mouth is asked " section, be commonly called as sneeze.Its justice i.e. " former sick formula six gas of Plain Questions arcane truth are the fiery class of disease " is said: " sneeze, in nose because the gas blowout of itching is made in sound also ".Under normal circumstances, sneezing is instinct instead of the morbid state of human body defence disease, therefore " Ling Shu Miraculous Pivot or Divine Axis mouth is asked " said: " person of sneezing of the people, does what gas make so? and qi uncle say: yang-energy and profit, Man Yuxin, for nose, therefore for sneezing ".But sneeze is frequently done, send out several even tens or dozens of successive, just belong to a kind of morbid state.In "Nei Jing", discuss compared with horn of plenty about allergic rhinitis etiology and pathogenesis, as " Ling Shu Miraculous Pivot or Divine Axis is declared five gas opinions " said: " five kinds of diseases caused by disorders of ZANG-QI, disorder of the kidney giving rise to sneezing and yawning ".The relation of nose and taste is mainly manifested in the taste QI and blood nose key of supplementing nutrition; Spleen the lucid yang sending up, clearing heat in QI system leads in aspects such as noses." the beautiful machine of Plain Questions is really hidden an opinion section ": " spleen is too late, make us nine orifices obstructed ".Nose and lung have extremely close relation, and its contact is mainly manifested in lung controlling nose, main tears, lung opening at nose.The capable breathing of nose, department's olfactory sensation, imperial exopathogen etc. are all closely related with lung.Lung qi fills Sheng, and nose obtains replenishing vital QI with drugs of warm nature, and smooth breathing, has a sharp sense of smell, imperial evil prosperous and powerful; Insufficiency of lung-QI, nose loses replenishing vital QI with drugs of warm nature, easily causes breath not smooth, and hyposmia is not driven exopathogen etc., therefore lung plays dominant force effect to the performance of the various functions of nose key.Lung contains that nose is strong, and the deficiency of the lung is a little less than nose, and lung is stopped up cacorhinia.Qing Dynasty's " miscellaneous diseases source and course rhinoceros candle " says: " have again allergic rhinitis person, rhinorrhea with clear discharge is more than, is caught cold also by lung meridian ".The etiology and pathogenesis of primary disease is lung, spleen, kidney three deficiency of five ZANG-organs damages, is attacked outward by the heresy of wind and cold unusual pathogen.It shows lung, and pathological change and spleen kidney have certain relation.

Anaphylactic disease mostly is due to ailment said due to cold or exposure invasion and attack epidermis, therefore, dispels the wind and also becomes the first-selected Therapeutic Method of allergic rhinitis.Chinese medicine think defend gas and there is warm boundary between muscles, fill skin, the merit of fertile space between skin and muscles, department's folding.Modern medicine is thought and is defended gas and refer to the defensive barrier of skin, mucosa, is the first line of defence of body infection and antagonism alterative inflammation.Therefore QI invigorating not only can stop exopathogen invasion, antiallergic, infection, antiinflammatory action that more can enhancing body.

Therefore, treatment primary disease is worked as taking replenishing QI to invigorate the spleen as main; Help with tonifying YANG consolidating superficial resistance the method that expelling wind and cold is sensible.

The present invention is exactly at replenishing QI to invigorate the spleen, tonifying YANG consolidating superficial resistance, on the sensible Therapeutic Principle of cold expelling, the method that adopts internal and external application to treat, endo-medicine and external used medicine are provided, endo-medicine is with replenishing QI to invigorate the spleen, tonifying YANG consolidating superficial resistance is main, be aided with expelling wind and cold, external used medicine plays effect of expelling wind and cold, and endo-medicine comprises following component: the Radix Astragali, Radix Polygoni Multiflori Preparata, the Rhizoma Atractylodis Macrocephalae, Flos Magnoliae, the Radix Angelicae Dahuricae, Ramulus Cinnamomi, Herba Centipedae, Radix Puerariae, Radix Codonopsis, Rhizoma Polygonati, Pericarpium Citri Reticulatae, Fructus Citri Sarcodactylis, Herba Cistanches, Semen Astragali Complanati, Herba Ecliptae, Poria, Radix Aconiti Lateralis Preparata, Cortex Cinnamomi.

Further, described endo-medicine is preferably only made up of said components.

In described endo-medicine, the gas of Radix Astragali function spleen reinforcing lung, again can consolidating superficial resistance, Radix Polygoni Multiflori Preparata invigorating the liver and kidney benefiting essence-blood, and can restrain essence and blood, the Rhizoma Atractylodis Macrocephalae is cultivated taste, Magnoliae Powder wind and cold, clearing the nasal passage, the loose wind dehumidifying of the Radix Angelicae Dahuricae, understand things pain-stopping, Ramulus Cinnamomi diaphoresis expelling pathogenic factors from muscles, warming the meridian and promoting blood circulation, Herba Centipedae dissipating blood stasis for subsidence of swelling, Radix Puerariae is delivered and is promoted the production of body fluid, Radix Codonopsis strengthening the spleen and tonifying the lung, supplementing QI for promoting the production of body fluid, Rhizoma Polygonati boosting qi and nourishing yin, enriching kidney essence, Pericarpium Citri Reticulatae regulating qi-flowing for strengthening spleen, circulation of qi promoting that Fructus Citri Sarcodactylis is soothing the liver, Herba Cistanches kidney-replenishing, benefiting essence-blood, Semen Astragali Complanati tonifying the kidney to consolidate the essence, Herba Ecliptae liver and kidney tonifying, Poria promoting diuresis to eliminate damp pathogen, Radix Aconiti Lateralis Preparata, Cortex Cinnamomi dispelling cold by warming the meridian.

In described endo-medicine, the weight portion of each component is the Radix Astragali 35 ~ 45 weight portions, Radix Polygoni Multiflori Preparata 20 ~ 30 weight portions, the Rhizoma Atractylodis Macrocephalae 30 ~ 40 weight portions, Flos Magnoliae 45 ~ 55 weight portions, the Radix Angelicae Dahuricae 40 ~ 50 weight portions, Ramulus Cinnamomi 15 ~ 25 weight portions, Herba Centipedae 15 ~ 25 weight portions, Radix Puerariae 10 ~ 20 weight portions, Radix Codonopsis 60 ~ 70 weight portions, Rhizoma Polygonati 30 ~ 40 weight portions, Pericarpium Citri Reticulatae 15 ~ 25 weight portions, Fructus Citri Sarcodactylis 10 ~ 20 weight portions, Herba Cistanches 30 ~ 40 weight portions, Semen Astragali Complanati 25 ~ 35 weight portions, Herba Ecliptae 25 ~ 35 weight portions, Poria 10 ~ 20 weight portions, Radix Aconiti Lateralis Preparata 10 ~ 20 weight portions, Cortex Cinnamomi 10 ~ 20 weight portions.

The more preferably Radix Astragali 40 ~ 45 weight portions of the weight portion of each component in described endo-medicine, Radix Polygoni Multiflori Preparata 25 ~ 30 weight portions, the Rhizoma Atractylodis Macrocephalae 35 ~ 40 weight portions, Flos Magnoliae 50 ~ 55 weight portions, the Radix Angelicae Dahuricae 45 ~ 50 weight portions, Ramulus Cinnamomi 20 ~ 25 weight portions, Herba Centipedae 20 ~ 25 weight portions, Radix Puerariae 10 ~ 15 weight portions, Radix Codonopsis 65 ~ 70 weight portions, Rhizoma Polygonati 35 ~ 40 weight portions, Pericarpium Citri Reticulatae 20 ~ 25 weight portions, Fructus Citri Sarcodactylis 15 ~ 20 weight portions, Herba Cistanches 35 ~ 40 weight portions, Semen Astragali Complanati 30 ~ 35 weight portions, Herba Ecliptae 30 ~ 35 weight portions, Poria 10 ~ 15 weight portions, Radix Aconiti Lateralis Preparata 10 ~ 15 weight portions, Cortex Cinnamomi 10 ~ 15 weight portions.

In described endo-medicine, the weight portion of each component is further preferably the Radix Astragali 40 weight portions, Radix Polygoni Multiflori Preparata 25 weight portions, the Rhizoma Atractylodis Macrocephalae 35 weight portions, Flos Magnoliae 50 weight portions, the Radix Angelicae Dahuricae 45 weight portions, Ramulus Cinnamomi 20 weight portions, Herba Centipedae 20 weight portions, Radix Puerariae 10 weight portions, Radix Codonopsis 65 weight portions, Rhizoma Polygonati 35 weight portions, Pericarpium Citri Reticulatae 20 weight portions, Fructus Citri Sarcodactylis 15 weight portions, Herba Cistanches 35 weight portions, Semen Astragali Complanati 30 weight portions, Herba Ecliptae 30 weight portions, Poria 10 weight portions, Radix Aconiti Lateralis Preparata 10 weight portions, Cortex Cinnamomi 10 weight portions.

In described endo-medicine, each component pharmacology is as follows:

The Radix Astragali: sweet in the mouth, warm in nature, enter spleen, lung meridian, there is tonification spleen soil, elevate a turnable ladder yang-energy, strengthening superficial resistance to stop perspiration, the effects such as holder skin ulcer granulation promoting, are mainly used in the weak anorexia and loose stool due to deficiency of both the splenic and pulmonary QI, shortness of breath and palpitation, the visceroptosis of sinking of QI of middle-JIAO, the metrorrhagia of QI failing to control blood is had blood in stool, chronic diarrhea proctoptosis; The spontaneous sweating of exterior deficiency, the cards such as insufficiency of vital energy and blood.The Radix Astragali can increase cellular immunization and humoral immune function, increases IgM, IgA in blood plasma, immunologic function is had to the effect of two-ways regulation.

Radix Polygoni Multiflori Preparata: bitter in the mouth, sweet, puckery, warm in nature, return liver, the heart, kidney channel, there is invigorating the liver and kidney, benefiting essence-blood, black beard and hair, effect of bone and muscle strengthening.Cure mainly blood deficiency and yellow complexion, vertigo and tinnitus, early whitening of beard and hair, soreness of the waist and knees, numb limbs and tense tendons, bleeding not during menses, chronic malaria body void; The cards such as hyperlipidemia.

The Rhizoma Atractylodis Macrocephalae: sweet in the mouth, hardship, warm in nature, enter spleen, stomach warp, there is spleen reinforcing promoting the circulation of QI, dampness diuretic, strengthening superficial resistance to stop perspiration, effect that activating the spleen is moisturized, cures mainly the feeling of fullness diarrhoea due to dysfunction of the spleen in transportation, QI failing to transform into body fluid, phlegm retention edema; The vexed lazy speech of deficiency of QI in middle-JIAO, metrorrhagia and metrostaxis, proctoptosis with chronic dysentery; The cards such as solid in the playing of deficiency of the spleen causing weakness of QI, sweating due to debility spontaneous perspiration.

Flos Magnoliae: acrid in the mouth, warm in nature, enter lung, stomach warp; the effect with expelling wind and cold, understand things pain-stopping, cures mainly headche due to wind-cold, dizzy; nasal sinusitis, nose cold current tears, toothache; the cards such as swelling of the face, Flos Magnoliae merit is apt to lung qi dispersing gas and clearing the nasal passage, is the special medicine for the treatment of nasal sinusitis; pharmacological action shows as protection nasal mucosa, promotes mucosa secretions to absorb, and reduces inflammation; short nasal cavity is unobstructed, antiallergic, anti-dopamine.

The Radix Angelicae Dahuricae: acrid in the mouth, warm in nature, enter lung, spleen, stomach warp, there is the cold expelling of inducing sweat, wind-expelling pain-stopping, clearing the nasal passage, dampness leukorrhagia stopping, effect of detumescence and apocenosis, cures mainly headache, supraorbital bone pain, toothache, nasal sinusitis, cold-damp stomachache, hemorrhoidal hamorrhage anal fistula, leucorrhea with red and white discharge, ulcer sores, skin pruritus due to dryness, the cards such as scabies.

Ramulus Cinnamomi: acrid in the mouth, sweet, warm in nature, GUIXIN, lung, urinary bladder channel, have diaphoresis expelling pathogenic factors from muscles, warming the meridian and promoting blood circulation, supporing yang activating QI, the effect of dispersing cold for relieving pain, Ramulus Cinnamomi warming the meridian and promoting blood circulation, horizontal logical podomere, for affection of exogenous wind-cold exterior syndrome, no matter have antiperspirant, losslessly all can apply, also for rheumatic arthralgia, cold syndrome of the stomach stomachache, amenorrhea, dysmenorrhea, rheumatic arthralgia, the cards such as shoulder arm podomere cold type of pain, phlegm retention syndrome and bladder water-retention, heart deficiency of spleen-YANG, retention of water-damp in the body, fullness and distention in the chest and hypochondrium, the dizzy phlegm retention syndrome that waits of cough with dyspnea.

Herba Centipedae: acrid in the mouth, warm in nature, enter lung, Liver Channel, there is cold-dispelling, clearing the nasal passage, eliminating phlegm and stopping cough, the effect of dissipating blood stasis for subsidence of swelling, for exterior syndrome due to wind-cold, nasal obstruction watery nasal discharge and nasal sinusitis, cough with copious phlegm, pertussis, the cards such as sore, carbuncle and painful swelling.

Radix Puerariae: sweet in the mouth, pungent, cool in nature, enter spleen, stomach warp, there is inspiration gastric qi, clearing away heat and promoting production of body fluid, expelling pathogenic factors from muscles is delivered, raw positive, oozes the effect of rash, is mainly used in fever caused by exogenous pathogens, headache, stiff nape and back, calentura is thirsty, quenches one's thirst; Diarrhea due to hypofunction of the spleen, the cards such as clear YANG failing to ascend.

Radix Codonopsis: sweet in the mouth, property is flat, enters lung, spleen channel, has QI invigorating strengthening the spleen, the effect of nourishing blood to promote the production of body fluid, be mainly used in deficiency of both the splenic and pulmonary QI or QI and blood deficiency fatigue and weakness, breathe hard, symptom such as cough spontaneous perspiration etc., Radix Codonopsis is longer than spleen reinforcing nourishing the stomach, adjust regulating the function of middle-JIAO, have the effect of nourishing blood concurrently, its property is flat, spleen invigorating fortune and not dry; Flavour is cloudy and not wet, can improve the immune state of body, improves resistance against diseases, and facilitating digestion absorbs, and improves metabolism, promotes the absorption of intestinal to nutrient substance.

Rhizoma Polygonati: sweet in the mouth, property is flat, enters lung, spleen, kidney channel, has nourishing kidney lung moistening, the effect of invigorating the spleen and replenishing QI, for lung-dryness syndrome due to deficiency of YIN, dry cough expectorant is few, the polydipsia of quenching one's thirst, weakness of the spleen and stomach, deficiency of spleen-QI or deficiency of spleen-YIN, deficiency of kidney essence, soreness of the waist and knees, the cards such as early whitening of beard and hair.

Pericarpium Citri Reticulatae: warm in nature, acrid in the mouth, hardship; Return spleen, lung meridian, for diseases such as distension and fullness of the chest and abdomen.The pungent loose logical temperature of Pericarpium Citri tangerinae, fragrant odour, is longer than and regulates the flow of vital energy, can enter spleen lung, thus can go loose sluggishness of lung-QI, again can promoting the circulation of QI to alleviate the stagnation in middle-JIAO, gather around the diseases such as stagnant, chest and diaphragm feeling of fullness and stagnation of QI in spleen and stomach, distension and fullness in the abdomen for lung qi, for retention of dampness in middle-JIAO, gastral cavity abdomen painful abdominal mass is swollen, have loose bowels in loose stool, and the card such as abundant expectoration cough.

Fructus Citri Sarcodactylis: acrid in the mouth, hardship, warm in nature, return liver, stomach, lung meridian, there is soothing the liver circulation of qi promoting, and in the effect of reducing phlegm, for the distending pain in the chest and hypochondrium of stagnation of QI due to depression of the liver, incoordination between the liver and stomach, stagnation of QI in spleen and stomach, the cards such as vomiting and nausea lack of appetite.

Herba Cistanches: sweet in the mouth, salty, warm in nature, enter kidney, large intestine channel, has kidney-replenishing, benefiting essence-blood, the effect of loosening bowel to relieve constipation, for kidney yang deficiency, the impotence and premature ejaculation of asthenia of essence and blood, sterility and infertility, soreness of waist and knee joint, Hiccough and deaf, frequent micturition urine number, suffer from a deficiency of the kidney dryness of the intestine and puerperal blood deficiency, the card such as constipation of deficiency of body fluid after being ill.

Semen Astragali Complanati: warm in nature, sweet in the mouth, has temperature compensation Liver and kidney, controlling nocturnal emission with astringent drugs, reducing urination, the effect of improving eyesight, for impotence due to deficiency of the kidney, seminal emission premature ejaculation, frequent micturition, or leukorrhagia, soreness of the waist and knees, lumbago; Deficiency of the liver and kindey, blurred vision order is dark, the cards such as visual deterioration.

Herba Ecliptae: sweet in the mouth, acid, cold in nature, return liver, kidney channel, play liver and kidney tonifying, the effect of cooling blood for hemostasis, for having a dizzy spell due to the hepatic and renal YIN deficiency, blurring of vision, soreness of the waist and knees; Being suitable for the deficiency of YIN has hot person, is used for the treatment of the haematemesis of accumulated heat in stomach, the cards such as the hemoptysis of injury of blood vessel of the lung by heat.

Poria: sweet in the mouth, light, property is flat, enters spleen, lung, bladder, heart channel, has the effect of eliminating dampness and diuresis, spleen invigorating mind calming, is mainly used in the edema of retention of water-damp, dysuria; The pyretic stranguria of damp-heat accumulation, the card such as the anorexia and loose stool of stagnation of dampness due to deficiency of the spleen, phlegm retention stagnation, epilepsy.

Radix Aconiti Lateralis Preparata: acrid in the mouth, sweet, extremely hot in nature, enter the heart, kidney, spleen channel, there is recuperating depleted YANG and rescuing the patient from collapse, mend fire supporing yang, dispelling cold by warming the meridian, the effect of removing damp and stopping pain, for excessive YIN keeping YANG externally, loss of YANG due to profuse perspiration, vomiting and diarrhoea is fainted contrary, cold extremities faint pulse, trusted subordinate's cold type of pain, cold-dysentery, beriberi edema, anemofrigid-damp arthralgia, sexual impotence, cold womb, deficiency and coldness is vomited and diarrhoea, YIN-cold edema, yang deficiency diseases caused by exogenous pathogenic factor, the cards such as the disease of carbuncle of yin nature skin infection and all chronic diseaseses.

Cortex Cinnamomi: extremely hot in nature, acrid in the mouth, sweet, returns kidney, spleen, the heart, Liver Channel, has the fire of benefit supporing yang, let the fire back to its origin, dispersing cold for relieving pain, effect of promoting blood circulation to restore menstrual flow, for warming the spleen and stomach, removing accumulated cold, promoting blood circulation.Control decline of the fire from the gate of life, cold extremities faint pulse, YANG-depletion collapse, stomachache is had loose bowels, colic of cold type renal mass, chills and pain of the waist and kness, amenorrhea lump in the abdomen, carbuncle of yin nature, multiple abscess, and empty sun is more floating, the cards such as heat in the upper and cold in the lower.

The dosage form of described endo-medicine can be: tablet, pin powder, capsule, hard capsule, soft capsule, oral liquid, granule, electuary, pill, powder, injection, be preferably oral liquid, powder.

In the time that the dosage form of described endo-medicine is powder, its preparation method is specially:

Second step, in concentrated solution, add determining alcohol be 80% ~ 90% ethanol to reaching more than 80% containing alcohol amount, cold preservation 24 hours at 4 DEG C, leach precipitation, reclaim ethanol, concentrated, dry, obtain and get dry extract, put into super micron mill and pulverize, obtain 200 order ~ 300 object ultra-micro powders, be endo-medicine powder, while taking, powder is dissolved in warm water, oral.

In the time that the dosage form of described endo-medicine is oral liquid, its preparation method is specially:

Second step, in concentrated solution, adding determining alcohol is that 80% ~ 90% ethanol is to reaching more than 80% containing alcohol amount, cold preservation 24 hours at 4 DEG C, with the centrifugal rear acquisition supernatant of high speed centrifuge, add the A Siba of 0.01 ~ 0.03 times of mixture quality of the original components obtaining with respect to the first step sweet, the sucrose of 0.01 ~ 0.03 times, add water to subsequently enough, stir, filter, embedding is in 10ml oral liquid bottle, 100 DEG C of sterilizings 30 minutes, packaging, to obtain final product, and the crude drug concentration in described oral liquid is 1g/ml ~ 1.5g/ml.

Described external used medicine is further only made up of said components.

Magnoliae Powder wind and cold, clearing the nasal passage in described external used medicine, the loose wind dehumidifying of the Radix Angelicae Dahuricae, understand things pain-stopping, Radix Scrophulariae nourishing YIN to lower pathogenic fire, detoxicating and resolving stagnation of pathogens, Fructus Gardeniae removing pathogenic heat from blood and toxic substance from the body, Herba Houttuyniae heat-clearing and toxic substances removing, inducing diuresis for treating stranguria syndrome, Rhizoma Gastrodiae dispelling wind and removing obstruction in the collateral, the Periostracum Cicadae dispelling wind nose of waking up, Radix Rhodiolae benefiting QI for activating blood circulation, Radix Curcumae promoting flow of QI and blood, Fructus Piperis Longi warming spleen and stomach for dispelling cold, the Rhizoma Acori Graminei refreshment of having one's ideas straightened out, Fructus Aurantii Immaturus dispelling the stagnated QI removing food stagnancy, Folium Et Cacumen Murrayae promoting the circulation of QI to relieve pain, promoting blood circulation to remove blood stasis, Rhizoma Phragmitis clearing away heat and promoting production of body fluid, Rhizoma Anemarrhenae clearing away heat-fire, Rhizoma Coptidis clearing away heat-fire, Fructus Anisi Stellati warming YANG to expel cold.

In described external used medicine, the weight portion of each component can be Flos Magnoliae 55 ~ 65 weight portions, the Radix Angelicae Dahuricae 35 ~ 45 weight portions, Radix Scrophulariae 15 ~ 25 weight portions, Fructus Gardeniae 20 ~ 30 weight portions, Herba Houttuyniae 15 ~ 25 weight portions, Rhizoma Gastrodiae 10 ~ 20 weight portions, Periostracum Cicadae 25 ~ 35 weight portions, Radix Rhodiolae 15 ~ 25 weight portions, Radix Curcumae 15 ~ 25 weight portions, Fructus Piperis Longi 15 ~ 25 weight portions, Rhizoma Acori Graminei 10 ~ 20 weight portions, Fructus Aurantii Immaturus 20 ~ 30 weight portions, Folium Et Cacumen Murrayae 15 ~ 25 weight portions, Rhizoma Phragmitis 25 ~ 35 weight portions, the Rhizoma Anemarrhenae 30 ~ 40 weight portions, Rhizoma Coptidis 35 ~ 45 weight portions, Fructus Anisi Stellati 10 ~ 20 weight portions.

In described external used medicine, the weight portion of each component can be further Flos Magnoliae 60 ~ 65 weight portions, the Radix Angelicae Dahuricae 40 ~ 45 weight portions, Radix Scrophulariae 15 ~ 20 weight portions, Fructus Gardeniae 25 ~ 30 weight portions, Herba Houttuyniae 15 ~ 20 weight portions, Rhizoma Gastrodiae 10 ~ 15 weight portions, Periostracum Cicadae 30 ~ 35 weight portions, Radix Rhodiolae 15 ~ 20 weight portions, Radix Curcumae 15 ~ 20 weight portions, Fructus Piperis Longi 15 ~ 20 weight portions, Rhizoma Acori Graminei 10 ~ 15 weight portions, Fructus Aurantii Immaturus 25 ~ 30 weight portions, Folium Et Cacumen Murrayae 20 ~ 25 weight portions, Rhizoma Phragmitis 30 ~ 35 weight portions, the Rhizoma Anemarrhenae 35 ~ 40 weight portions, Rhizoma Coptidis 40 ~ 45 weight portions, Fructus Anisi Stellati 10 ~ 15 weight portions.

In described external used medicine, the weight portion of each component can be further Flos Magnoliae 60 weight portions, the Radix Angelicae Dahuricae 40 weight portions, Radix Scrophulariae 15 weight portions, Fructus Gardeniae 25 weight portions, Herba Houttuyniae 15 weight portions, Rhizoma Gastrodiae 10 weight portions, Periostracum Cicadae 30 weight portions, Radix Rhodiolae 15 weight portions, Radix Curcumae 15 weight portions, Fructus Piperis Longi 15 weight portions, Rhizoma Acori Graminei 10 weight portions, Fructus Aurantii Immaturus 25 weight portions, Folium Et Cacumen Murrayae 20 weight portions, Rhizoma Phragmitis 30 weight portions, the Rhizoma Anemarrhenae 35 weight portions, Rhizoma Coptidis 40 weight portions, Fructus Anisi Stellati 10 weight portions.

In described external used medicine, the pharmacology of each component is as follows:

Radix Scrophulariae: sweet in the mouth, hardship, salty, cold nature, returns lung, stomach, kidney channel, there is clearing away heat and cooling blood, eliminating fire and detoxication, YIN nourishing is supported effect of kidney, curing mainly pathogenic warmth joins the army, the pericardium that caves in, maculae caused by violent heat pathogen, the cards such as constipation, hectic fever due to YIN-deficiency chronic cough, conjunctival congestion, pharyngalgia, scrofula, diphtheria, carbuncle sore tumefacting virus are hindered in consumption of YIN caused by febrile disease, crimson tongue excessive thirst, Tianjin.

Fructus Gardeniae: bitter in the mouth, cold in nature, enter the heart, lung, three warmers, have the effect of relieving restlessness pathogenic fire purging, dispersing the stagnated live-QI to relieve the stagnation of QI, clearing away heat-damp and promoting diuresis, cooling blood for hemostasis, be mainly used in epidemic febrile disease heat stagnation breast gastral cavity vexed uneasiness, bother not peaceful; Stagnation of liver-QI is not relaxed or Liver Channel has having a dizzy spell of heat, pain in chest and hypochondrium, conjunctival congestion dry pharynx; Jaundice due to damp-heat; The cards such as the abdominal distention of qi depression to blood stasis.

Herba Houttuyniae: acrid in the mouth, cold nature, enters lung, urinary bladder channel, has heat-clearing and toxic substances removing, removing pus and relieving carbuncle, effect of inducing diuresis for treating stranguria syndrome, for lung abscess vomiting pus, expectorant heat syndrome cough is breathed heavily, toxic-heat and blood stasis, damp-heat gonorrhoea, pyretic toxicity carbuncle sore, snakeworm is wanted first-class card.

Rhizoma Gastrodiae: sweet in the mouth, property are flat, enter Liver Channel, have suppressing the hyperactive liver to relieve the wind syndrome, spasmolytic, the effect of removing obstruction in the collateral to relieve pain, is mainly used in the dizzy headache of flaming up of liver-fire, the card such as strong wind tic, epilepsy due to excessive rising of liver-YANG, liver-wind stirring up internally.

Periostracum Cicadae: sweet in the mouth, lung, the Liver Channel of returning cold in nature, there is a surname's wind heat extraction, rash, sore-throat relieving, effect of spasmolytic, cure mainly affection due to external wind and heat or epidemic febrile disease from the beginning of due to heating, cough, pharyngalgia, pharynx mute, measles is sent out not smooth thoroughly, rubella pruritus, wind-heat of liver channel, the cards such as the many tears of conjunctival congestion.

Radix Rhodiolae: sweet in the mouth, hardship, property is flat, returns lung, heart channel, has benefiting QI for activating blood circulation, the effect of promoting blood circulation and relievining asthma, for blood stasis due to qi deficiency, obstruction of qi in the chest and cardialgia, apoplectic hemiplegia, the cards such as asthenia asthma.

Radix Curcumae: acrid in the mouth, hardship, cold in nature, return liver, the heart, lung meridian, there is regulating qi to disperse stagnation, heart fire-clearing upset-relieving, effect of promoting the function of the gallbladder to alleviate jaundice, cures mainly amenorrhea dysmenorrhea, chest and abdomen swelling and pain, twinge, calentura coma, the card such as epilepsy is gone mad, jaundice dark coloured urine.

Fructus Piperis Longi: acrid in the mouth, hot in nature, return stomach, large intestine channel, there is warming spleen and stomach for dispelling cold, effect of therapeutic method to keep the adverse QI flowing downwards pain relieving, cures mainly coldness and pain in the epigastrium, vomiting singultus, dysentery, headache, toothache, the cards such as nasal sinusitis.

Rhizoma Acori Graminei: acrid in the mouth, warm in nature, enter the heart, stomach warp, has the refreshment of having one's ideas straightened out, and effect of removing dampness to restore normal function of the stomach is used for the treatment of expectorant and covers clear key, and coma is demented, dizziness, insomnia, forgetful, tinnitus, retention of dampness in middle-JIAO, the cards such as abdominal distention.

Fructus Aurantii Immaturus: bitter in the mouth, pungent, cold nature, enters spleen, stomach warp, has dispelling the stagnated QI removing food stagnancy, and expectorant is except the effect of painful abdominal mass, is mainly used in stagnant stopping, the excess syndrome of YANG MING FU-organ card of distension and fullness in the abdomen, constipation.

Folium Et Cacumen Murrayae: acrid in the mouth, micro-hardship, warm in nature, slightly poisonous, there is effect of promoting the circulation of QI to relieve pain, promoting blood circulation to remove blood stasis, for stomachache, rheumatic arthralgia, treating swelling and pain by traumatic injury, fracture, sore and toxic, venom, the cards such as eczema.

Rhizoma Phragmitis: sweet in the mouth, cold in nature, attach to the lung and stomach meridians, there is lung heat clearing gastric heat, diuresis, dissipating depression of QI clearing away phlegm, effect of YIN nourishing and the production of body fluid promoting, cure mainly the dysphoria with smothery sensation that epidemic febrile disease joins the army point thirsty, dryness of the tongue Tianjin is few, and the rash of measles goes out not saturating, and pathogenic heat is violated the cough and expectoration of lung, the cough vomiting pus of lung abscess, the damp and hot retardance in cards such as the vomiting singultuss of stomach.

The Rhizoma Anemarrhenae: bitter in the mouth, sweet, cold in nature, enter lung, stomach, kidney channel, there is the relieving restlessness of purging heat, the effect of nourshing Yin and drynsessmoistening prescription, clearing away lung-heat to relieve cough, cures mainly fever caused by exogenous pathogenic factors, and high heat is irritated, lung-heat type cough, the interior-heat symptom such as quench one's thirst; Its bitter cold matter profit, property sedimentation, can heat clearing away, can promote the production of body fluid again, kindly controls warm pathogenic factor and enters edema caused by disorder of QI, intenseness of heat impairment of body fluid; Also be used for the treatment of diabetes; Phlegm-heat obstructing in the lung and breathing heavily, xeropulmonary cough, expectorant is few unfavorable; Hyperactivity of fire caused by deficiency of YIN, the cards such as hyperactivity of deficient fire.

Rhizoma Coptidis: bitter in the mouth, cold in nature, enter the heart, lung, gallbladder, stomach, large intestine channel, there is the effect of heat clearing and damp drying, eliminating fire and detoxication, cooling blood for improving eyesight, be longer than the fire of removing pathogen in the heart warp, can be used for treating the dysphoria and insomnia of heart-fire due to prosperous, and the high fever coma of epidemic febrile disease, vexed, thirsty; Also can be used for dysentery, tenesmus due to damp and hot; The cards such as pyretic toxicity carbuncle sore, eczema, aphtha of the mouth and tongue, epidemic hemorrhagic conjunctivitis.

Fructus Anisi Stellati: acrid in the mouth, warm in nature, return liver,kidney,spleen warp, there is effect of warming YANG to expel cold, regulating QI to relieve pain, cure mainly colic of cold type stomachache, lumbago due to renal deficiency, coldness and pain in the epigastrium, the cards such as vomiting lack of appetite.

The dosage form of described external used medicine can be unguentum, spray, medical gauze, patch, smear agent or tincture, is preferably spray.

When the dosage form of described external used medicine is spray, its preparation method is:

The powder 1 of endo-medicine prepared by the present invention

By Radix Astragali 400g, Radix Polygoni Multiflori Preparata 250g, Rhizoma Atractylodis Macrocephalae 350g, Flos Magnoliae 500g, Radix Angelicae Dahuricae 450g, Ramulus Cinnamomi 200g, Herba Centipedae 200g, Radix Puerariae 100g, Radix Codonopsis 650g, Rhizoma Polygonati 350g, Pericarpium Citri Reticulatae 200g, Fructus Citri Sarcodactylis 150g, Herba Cistanches 350g, Semen Astragali Complanati 300g, Herba Ecliptae 300g, Poria 100g, Radix Aconiti Lateralis Preparata 100g, Cortex Cinnamomi 100g is ground into respectively 30 object powder, put into blender and be uniformly mixed, add the water of 12kg, decoct 5 hours, decoction liquor is filtered, obtain the first filtrate, the filtering residue that filters acquisition is added to the water of 2kg, again decoct 5 hours, decoction liquor is filtered, obtain the second filtrate, the first filtrate and the second filtrate are mixed to acquisition mixed liquor, concentrated except anhydrating, obtain concentrated solution, the volume of the concentrated solution after concentrated be concentrated before mixed liquor 1/5, in concentrated solution, add determining alcohol be 90% ethanol to reaching more than 80% containing alcohol amount, cold preservation 24 hours at 4 DEG C, leach precipitation, reclaim ethanol, concentrated, dry, obtain and get dry extract, put into super micron mill and pulverize, obtain 200 object ultra-micro powders, be endo-medicine powder 1.

The pharmacological experiment research of this powder 1

Acute toxicity testing

Select 50 of Kunming kind white mice, male and female half and half, body weight is 18 ~ 24g, be divided at random 5 groups, every group 10, the 500g powder 1 of preparing is above dissolved in the water of 500ml, be prepared into the outstanding mixed liquid of 1g/ml, adopt oral administration gavage method to carry out administration, the dose of 5 groups of administrations is respectively 30g/kg, 25g/kg, 15g/kg, 5g/kg and normal saline matched group, and every group is repeated to test twice, animal dead situation in 1 week after observation administration, none death of result animal, feed, behavioral activity, Normal-weight; The important organs such as the naked eyes portion inspection heart, liver, spleen, lung, kidney, result, all without abnormal change, is dissected and is made each organs and tissues and learn inspection, is showed no abnormal pathological change.Further, DM used also has no mice is produced to acute toxic reaction to 32g/kg (be equivalent to crude drug quantity 64 times).

Long term toxicity test

Select 30 of Cavia porcelluss, male and female half and half, body weight is 250 ~ 300g, so that the 500g powder 1 of preparing is above dissolved in the water of 500ml, obtain outstanding mixed liquid and drink 3 months, every day 3 times, each 5ml, during medication, examine the growth promoter of animal, behavioral activity, feed water inlet, breathe, body temperature, hematuria routine, hepatic and renal function and other reactions, medication has no the above every observation index of experimental guinea pig for 3 months and occurs abnormal change, or Cavia porcellus death, Cavia porcellus is dissected and makes each organs and tissues and learn inspection, is showed no abnormal pathological change.

Endo-medicine powder 2 prepared by the present invention

By Radix Astragali 450g, Radix Polygoni Multiflori Preparata 270g, Rhizoma Atractylodis Macrocephalae 390g, Flos Magnoliae 550g, Radix Angelicae Dahuricae 480g, Ramulus Cinnamomi 230g, Herba Centipedae 220g, Radix Puerariae 120g, Radix Codonopsis 690g, Rhizoma Polygonati 380g, Pericarpium Citri Reticulatae 220g, Fructus Citri Sarcodactylis 160g, Herba Cistanches 390g, Semen Astragali Complanati 340g, Herba Ecliptae 330g, Poria 120g, Radix Aconiti Lateralis Preparata 110g, Cortex Cinnamomi 120g is ground into respectively 30 object powder, put into blender and be uniformly mixed, add the water of 13kg, decoct 5 hours, decoction liquor is filtered, obtain the first filtrate, the filtering residue that filters acquisition is added to the water of 2kg, again decoct 5 hours, decoction liquor is filtered, obtain the second filtrate, the first filtrate and the second filtrate are mixed to acquisition mixed liquor, concentrated except anhydrating, obtain concentrated solution, the volume of the concentrated solution after concentrated be concentrated before mixed liquor 1/5, in concentrated solution, add determining alcohol be 90% ethanol to reaching more than 80% containing alcohol amount, cold preservation 24 hours at 4 DEG C, leach precipitation, reclaim ethanol, concentrated, dry, obtain and get dry extract, put into super micron mill and pulverize, obtain 200 object ultra-micro powders, be endo-medicine powder 2.

Endo-medicine oral liquid prepared by the present invention

By Radix Astragali 440g, Radix Polygoni Multiflori Preparata 280g, Rhizoma Atractylodis Macrocephalae 390g, Flos Magnoliae 540g, Radix Angelicae Dahuricae 470g, Ramulus Cinnamomi 220g, Herba Centipedae 210g, Radix Puerariae 130g, Radix Codonopsis 680g, Rhizoma Polygonati 390g, Pericarpium Citri Reticulatae 210g, Fructus Citri Sarcodactylis 170g, Herba Cistanches 380g, Semen Astragali Complanati 330g, Herba Ecliptae 340g, Poria 110g, Radix Aconiti Lateralis Preparata 120g, Cortex Cinnamomi 110g is all ground into 30 object powder, putting into blender is uniformly mixed, add the water of 13kg, decoct 5 hours, decoction liquor is filtered, obtain the first filtrate, the filtering residue that filters acquisition is added to the water of 3kg, again decoct 5 hours, decoction liquor is filtered, obtain the second filtrate, the first filtrate and the second filtrate are mixed to acquisition mixed liquor, concentrated except anhydrating, obtain concentrated solution, the volume of the concentrated solution after concentrated is 1/5 of concentrated front mixed liquor, in concentrated solution, adding determining alcohol is that 90% ethanol is to reaching more than 80% containing alcohol amount, cold preservation 24 hours at 4 DEG C, with the centrifugal rear acquisition supernatant of high speed centrifuge, add the A Siba of 60g sweet, the sucrose of 110g, add water to subsequently enough, stir, filter, embedding is in 10ml oral liquid bottle, 100 DEG C of sterilizings 30 minutes, packaging, obtain, crude drug concentration in described oral liquid is 1g/ml.

External used medicine spray 1 prepared by the present invention

By Flos Magnoliae 600g, Radix Angelicae Dahuricae 400g, Radix Scrophulariae 150g, Fructus Gardeniae 250g, Herba Houttuyniae 150g, Rhizoma Gastrodiae 100g, Periostracum Cicadae 300g, Radix Rhodiolae 150g, Radix Curcumae 150g, Fructus Piperis Longi 150g, Rhizoma Acori Graminei 100g, Fructus Aurantii Immaturus 250g, Folium Et Cacumen Murrayae 200g, Rhizoma Phragmitis 300g, Rhizoma Anemarrhenae 350g, Rhizoma Coptidis 400g, Fructus Anisi Stellati 100g is all ground into 30 object powder, putting into blender is uniformly mixed, add the water of 15kg, decoct 5 hours, decoction liquor is filtered, obtain the first filtrate, the filtering residue that filters acquisition is added to the water of 2kg, again decoct 5 hours, decoction liquor is filtered, obtain the second filtrate, the first filtrate and the second filtrate are mixed to acquisition mixed liquor, concentrated except anhydrating, obtain concentrated solution, the volume of the concentrated solution after concentrated is 1/5 of concentrated front mixed liquor, in concentrated solution, adding determining alcohol is that 90% ethanol is to reaching more than 80% containing alcohol amount, cold preservation 24 hours at 4 DEG C, leach precipitation, reclaim ethanol, concentrated, dry, obtain and get dry extract, putting into super micron mill pulverizes, obtain 300 object ultra-micro powders, the ultra-micro powder of acquisition is placed in to the water of 20kg, stirring and dissolving, to be dissolvedly add 1.25kg surfactant polyethylene 300 quantitative separatings in the aerosol pressure vessel of 10ml after completely, be pushed down into 20ml propellant tetrafluoroethane in the interpolation of 100Kpa again, make spray 1.

External spraying agent acute toxicity testing

By 30 of Kunming kind white mice, male and female half and half, body weight is 18 ~ 24g, be divided into 3 groups, spray respectively the spray 1 of preparing at mice face above, spray every day 3 times, the amount that spray every day is respectively 2ml, 4ml and 6ml, uses continuously 7, none death of result mice, feed, behavioral activity, Normal-weight, the important organs such as the naked eyes portion inspection heart, liver, spleen, lung, kidney, result, all without abnormal change, is put to death mice, dissect and make each organs and tissues and learn inspection, being showed no abnormal pathological change.

Skin allergy experiment

By 30 of Cavia porcelluss, male and female half and half, body weight 250 ~ 300g, is divided into 3 groups, Cavia porcellus is fixed, reject the dorsal body setae of body surface 3 × 3cm, spray respectively the spray 1 of preparing thereon above, spray every day 3 times, the amount that spray every day is respectively 2ml, 4ml and 6ml, use 7 continuously, show through experiment, skin allergy experiment is negative.

External used medicine spray 2 prepared by the present invention

By Flos Magnoliae 640g, Radix Angelicae Dahuricae 430g, Radix Scrophulariae 170g, Fructus Gardeniae 280g, Herba Houttuyniae 160g, Rhizoma Gastrodiae 110g, Periostracum Cicadae 320g, Radix Rhodiolae 180g, Radix Curcumae 190g, Fructus Piperis Longi 160g, Rhizoma Acori Graminei 120g, Fructus Aurantii Immaturus 280g, Folium Et Cacumen Murrayae 220g, Rhizoma Phragmitis 330g, Rhizoma Anemarrhenae 380g, Rhizoma Coptidis 430g, Fructus Anisi Stellati 120g is all ground into 30 object powder, putting into blender is uniformly mixed, add the water of 15kg, decoct 5 hours, decoction liquor is filtered, obtain the first filtrate, the filtering residue that filters acquisition is added to the water of 2kg, again decoct 5 hours, decoction liquor is filtered, obtain the second filtrate, the first filtrate and the second filtrate are mixed to acquisition mixed liquor, concentrated except anhydrating, obtain concentrated solution, the volume of the concentrated solution after concentrated is 1/5 of concentrated front mixed liquor, in concentrated solution, adding determining alcohol is that 90% ethanol is to reaching more than 80% containing alcohol amount, cold preservation 24 hours at 4 DEG C, leach precipitation, reclaim ethanol, concentrated, dry, obtain and get dry extract, putting into super micron mill pulverizes, obtain 300 object ultra-micro powders, the ultra-micro powder of acquisition is placed in to the water of 20kg, stirring and dissolving, to be dissolvedly add 1.25kg surfactant polyethylene 300 quantitative separatings in the aerosol pressure vessel of 10ml after completely, be pushed down into 20ml propellant tetrafluoroethane in the condition of 100Kpa again, make spray 2.

Zoopery

Laboratory animal and model are set up

Get 85 of Cavia porcelluss, inbred line clean animal, male and female half and half, weight (300 ± 20) g, is provided by Shandong University's Experimental Animal Center, and sub-cage rearing is freely taken the photograph water and is ingested.Wherein 20 is solvent matched group, and other 65 adopt ovalbumin sensitization legal system to make allergic rhinitis in guinea-pig model.Every Cavia porcellus is using ovalbumin 0.3mg as antigen, and aluminium-hydroxide powder 30mg, as adjuvant, adds normal saline 1mL and makes suspension, gavage, the next day 1 time, totally 7 times is basic sensitization.Then with 2g/L ovalbumin normal saline solution collunarium, every side 10 μ L, continuous 7 days.

Medicine and reagent

The endo-medicine powder 1 that the present invention is prepared and external used medicine spray 1, SERUM IgE and histamine test kit are provided by Beijing Bo Aosen company.

Grouping and administration

Modeling animal, in last nasal cavity sensitization 30 minutes, adopts " quantizing stack scoring method " to carry out index scoring to Cavia porcellus behavioristics index, and stack total score >=5 are modeling success.Get 60 of modeling success Cavia porcelluss, be divided at random 4 groups: model group, Cetirizine hydrochloride Tablets group, takes the experimental group of powder 1 prepared by the present invention and spray 1 together with solvent matched group, and totally 4 groups, 20 every group.Experimental group is dissolved in powder 1 solution that obtains 1g/ml concentration in water every day, gavage Cavia porcellus, every day 3 times, 10mL/ every day (kgd), meanwhile, spray prepared by the present invention spray 1 to Cavia porcellus nose every day, every day 3 times, 6mL/ every day (kgd), model control group and solvent matched group give equivalent normal saline, and Cetirizine hydrochloride Tablets group gives Cetirizine hydrochloride Tablets 0.3mg/ (kgd) gavage.Successive administration 4 weeks.

Index detects

Cavia porcellus is anaesthetized by 20% urethane gavage, and dorsal position is fixed, ventral aorta blood sampling, and separation of serum, ELISA method detects IgE and Plasma Histamine content in serum.

Date processing

Select SPSS 11.0 to carry out statistical analysis, data are with mean ± standard deviation represent.

Experimental result

The variation of IgE content in each group guinea pig serum, in table 1.

OVA-sIgE concentration in table 1 guinea pig serum ng/mL

Group	OVA-sIgE
		Solvent matched group	9.36±0.99

Model group	36.37±1.31 ^##
		Cetirizine hydrochloride Tablets group	15.21±1.37 ^##△
Experimental group	10.02±0.46 ^##△

Note: with the comparison of solvent matched group, ^##p<0.01; With model group comparison, ^△p<0.05.The variation of histamine concentration in each group guinea pig serum, in table 2.

Histamine concentration in table 2 guinea pig serum ng/mL

Group	Histamine concentration
		Solvent matched group	6.73±0.27
Model group	15.37±1.08 ^##
		Cetirizine hydrochloride Tablets group	9.17±0.92 ^##△
Experimental group	7.13±0.41 ^##△

Note: with the comparison of solvent matched group, ^##p<0.01; With model group comparison, ^△p<0.05.

The plasma cell that IgE is mainly located in mucosa lamina propria by respiratory tract (nasopharynx, tonsil and bronchus) and digestive tract etc. produces, and in asthma, during allergic rhinitis develops, plays crucial mediation.Histamine, as a kind of important inflammatory mediator, is participated in allergic rhinitis Immunological Pathogenesis directly.Histamine by basophil and mastocyte irriate after de-granule produce, thereby act on that H1 receptor causes that vasodilation, tube wall permeability increase, glandular secretion increases and neural reflex etc.

Chinese medicine external medicine provided by the invention and endo-medicine can reduce IgE concentration and histamine concentration in allergic rhinitis model guinea pig serum, allergic rhinitis in guinea-pig model is had to good therapeutical effect, with respect to hismanal, can alleviate the sensitization of body, stop inflammatory mediator histamine release, reduce SERUM IgE content, have better therapeutic effect for allergic rhinitis.

Clinical efficacy

Patient's data

This group patient 240 examples, are allergic rhinitis patients, and diagnostic criteria reference Lanzhou meeting in 2004 is about " principle of diagnosis and treatment of allergic rhinitis and suggested design ".Wherein male's 126 examples, women's 114 examples, at 18～60 years old age, average 37.5 years old, be divided into immediately in proportion 2 groups, treatment by Chinese herbs group 160 examples, western medicine group 80 examples, 2 groups of patients there are no significant at aspects such as sex, age, courses of disease difference (P > 0.05), has comparability, skin prick test is positive, and has at least a kind of for (++) or more than (++).Clinical symptoms: when this onste main manifestations be watery nasal discharge as water, nasal obstruction, rhinocnesmus, sneeze are frequent, are paroxysmal, have outbreak and the feature of outbreak repeatedly.Once used allergy preparations, the treatments such as histamine's desensitization, sealing, immunotherapy, hormone, all fail effectively to control.

Above-mentioned treatment group patient is divided into 1. deficiency of both the splenic and pulmonary QI type 47 examples by theory of Chinese medical science: paroxysmal rhinocnesmus, sneeze, nasal mucus are clear or glutinous white, sooner or later easily send out, and meet air-cooled increasing the weight of, and nasal obstruction nose is swollen obviously, and baryo,dmia, can be nose heave with giddy, extremity are sleepy, poor appetite, stool or half congealed.Check visible two Carapax et Plastrum Testudinis mucosa swelling, color and luster is pale or gloomy.Pale tongue is fat, and there is indentation on limit, and tongue is white, thready and weak pulse; 2. deficiency of spleen and stomach type 42 examples: shallow complexion is simple and unadorned, deficiency of QI with disinclination to talk, lack of appetite is indigestion and loss of appetite, becomes thin, abdominal distention loose stool, extremity fatigue and weakness, corpulent tongue, white and thin fur, there is indentation on limit, and weak pulse is unable; 3. stagnant pulmonary type 40 examples of wind and cold: pale complexion, tired, moving asthma; Between larynx, there is rale sound, coldness of the body with chills, nasal obstruction, mouth breathing, sneeze is few, pale tongue, tongue is white, deep,thready and forceless pulse; 4. qi stagnation and blood stasis type 31 examples: nasal obstruction, the sticky color of nasal mucus is white, occasionally has the blood streak, have a dull expression on one's face, baryo,dmia, dizzy tinnitus, hypomnesis.Red tongue, Tai Bai or Huang, rapid pulse.

Exclusion standard

The serious primary disease such as liver, kidney, hemopoietic system, psychotic; Gestation or women breast-feeding their children, and to Western medicine cetirizine allergy sufferers; In 2 weeks, use other antihistaminics or mastocyte membrane stabilizer; Oral glucocorticoid person in 4 weeks; Not medication in accordance with regulations, cannot judge the not congruent judgement person of affecting the treatment of curative effect or data.

Therapeutic Method

Treatment group: 500g powder 1 is dissolved in 500ml water, is uniformly dissolved, oral for patient, each 250ml, every day 3 times, meanwhile, adopts spray 1 to the spraying of patient's nose affected part every day, sprays 5 ~ 7 every day, within 7 days, is 1 course for the treatment of, takes altogether 4 courses for the treatment of.

Matched group: oral hydrochloride cetirizine sheet, 10mg/ time, oral 1 time every night 7 days is 1 course for the treatment of, takes altogether 4 courses for the treatment of.

Observation index and method

2 groups are all carried out symptom, sign scoring before and after taking medicine.Symptom, sign scoring adopt scoring method: sneeze, and 1 time 3 of < are 0 point, and 3～9 is 1 point, and 10～14 is 2 points, and 15 of > are 3 points; Watery nasal discharge, does nothing 0 point, is on a small quantity 1 point, and not autonomous watery nasal discharge is 2 points, and watery nasal discharge is 3 points incessantly; Nasal obstruction, does nothing 0 point, and discontinuity nasal obstruction is 1 point, and lasting ventilation is not freely 2 points, and nasal obstruction is serious, and needing mouth breathing is 3 points; Rhinocnesmus, does nothing 0 point, and being interrupted rhinocnesmus is 1 point, the sense of ant row, and can stand is 2 points, the sense of ant row, is 3 points unbearably.

Sign classification: nasal septum, middle nasal concha are visible as 0 point; Concha nasalis inferior mild swelling, nasal septum, middle nasal concha are still visible as 1 point; At the bottom of concha nasalis inferior and nose or between nasal septum, only having small gap is 2 points; At the bottom of concha nasalis inferior and nose, nasal septum is close to, middle nasal concha mucosa Polypoid changes, polyp form 3 points.

Efficacy evaluation mark

Short term effect evaluation criteria: according to " diagnosis of allergic rhinitis standard and the efficacy assessment standard " of the academic meeting revision of 1997 (Haikou) Chinese ear,nose & throat.According to the total score that before and after treatment, sings and symptoms is scored, the percentage rate improving is evaluated the curative effect of allergic rhinitis by following formula: (total score after the front total score-treatment for the treatment of) front total score × 100% of/treatment, >=51% is effective, < 50%, > 21% is that effectively≤20% is invalid.

Untoward reaction is observed

Before and after observing treatment, make blood, urine, feces routine, hepatic and renal function inspection, time, persistent period, symptom and treatment measures that observed and recorded untoward reaction occurs.

Statistical procedures

The difference of index and data according to the observation, mean ± standard deviation for measurement data represent, between 2 groups of means, relatively adopt t inspection, enumeration data chi-square criterion.SPSS12.0 statistical package processing for data acquisition.

Result

The all types of patient's efficacy analysis for the treatment of group, the results are shown in Table 3.

The all types of efficacy analysis of table 3 [example (%)]

Treatment group and matched group patient efficacy analysis, the results are shown in Table 4.

Table 4 treatment group and the comparison of matched group curative effect

Group	Number of cases	Effective	Effectively	Invalid	Total effective rate
						Treatment group	160	93	55	12	92.5%
Matched group	80	27	37	16	80%

As can be seen from Table 4, the external used medicine that prepared by employing the present invention and the therapeutic effect of endo-medicine are better than western medicine group.

Before and after 2 groups of treatments, symptom and sign scoring is compared, in table 5.

Before and after table 5 treatment group and treatment of control group, symptom, sign scoring are relatively

Group	Number of cases	Before treatment	After treatment
				Treatment group	160	9.3817±1.6639	3.6153±1.3851
Matched group	80	9.4158±1.8169	4.2938±1.1037

Untoward reaction

In 2 groups of case therapeutic processes, blood, urine, feces, hepatic and renal function inspection are all within normal range.Matched group many cases patient is reflected drowsiness, xerostomia during medication, the adverse effect such as sleepy, and untoward reaction seldom occurs treatment group, shows to have good safety.

All above-mentioned these intellectual properties of primary enforcement, do not set restriction this new product of other forms of enforcement and/or new method.Those skilled in the art will utilize this important information, and foregoing amendment, to realize similar implementation status.But all modifications or transformation belong to the right of reservation based on new product of the present invention.

The above, be only preferred embodiment of the present invention, is not the restriction of the present invention being made to other form, and any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the equivalent embodiment of equivalent variations.But every technical solution of the present invention content that do not depart from, any simple modification, equivalent variations and the remodeling above embodiment done according to technical spirit of the present invention, still belong to the protection domain of technical solution of the present invention.

Claims

1. the Chinese medicine composition that is used for the treatment of allergic rhinitis, is characterized in that: be made up of endo-medicine and external used medicine;

Described endo-medicine is made up of the Radix Astragali, Radix Polygoni Multiflori Preparata, the Rhizoma Atractylodis Macrocephalae, Flos Magnoliae, the Radix Angelicae Dahuricae, Ramulus Cinnamomi, Herba Centipedae, Radix Puerariae, Radix Codonopsis, Rhizoma Polygonati, Pericarpium Citri Reticulatae, Fructus Citri Sarcodactylis, Herba Cistanches, Semen Astragali Complanati, Herba Ecliptae, Poria, Radix Aconiti Lateralis Preparata, Cortex Cinnamomi;

Described external used medicine is made up of Flos Magnoliae, the Radix Angelicae Dahuricae, Radix Scrophulariae, Fructus Gardeniae, Herba Houttuyniae, Rhizoma Gastrodiae, Periostracum Cicadae, Radix Rhodiolae, Radix Curcumae, Fructus Piperis Longi, Rhizoma Acori Graminei, Fructus Aurantii Immaturus, Folium Et Cacumen Murrayae, Rhizoma Phragmitis, the Rhizoma Anemarrhenae, Rhizoma Coptidis, Fructus Anisi Stellati;

In described endo-medicine, the weight portion of each component is the Radix Astragali 35～45 weight portions, Radix Polygoni Multiflori Preparata 20～30 weight portions, the Rhizoma Atractylodis Macrocephalae 30～40 weight portions, Flos Magnoliae 45～55 weight portions, the Radix Angelicae Dahuricae 40～50 weight portions, Ramulus Cinnamomi 15～25 weight portions, Herba Centipedae 15～25 weight portions, Radix Puerariae 10～20 weight portions, Radix Codonopsis 60～70 weight portions, Rhizoma Polygonati 30～40 weight portions, Pericarpium Citri Reticulatae 15～25 weight portions, Fructus Citri Sarcodactylis 10～20 weight portions, Herba Cistanches 30～40 weight portions, Semen Astragali Complanati 25～35 weight portions, Herba Ecliptae 25～35 weight portions, Poria 10～20 weight portions, Radix Aconiti Lateralis Preparata 10～20 weight portions, Cortex Cinnamomi 10～20 weight portions,

In described external used medicine, the weight portion of each component is Flos Magnoliae 55～65 weight portions, the Radix Angelicae Dahuricae 35～45 weight portions, Radix Scrophulariae 15～25 weight portions, Fructus Gardeniae 20～30 weight portions, Herba Houttuyniae 15～25 weight portions, Rhizoma Gastrodiae 10～20 weight portions, Periostracum Cicadae 25～35 weight portions, Radix Rhodiolae 15～25 weight portions, Radix Curcumae 15～25 weight portions, Fructus Piperis Longi 15～25 weight portions, Rhizoma Acori Graminei 10～20 weight portions, Fructus Aurantii Immaturus 20～30 weight portions, Folium Et Cacumen Murrayae 15～25 weight portions, Rhizoma Phragmitis 25～35 weight portions, the Rhizoma Anemarrhenae 30～40 weight portions, Rhizoma Coptidis 35～45 weight portions, Fructus Anisi Stellati 10～20 weight portions.

2. Chinese medicine composition as claimed in claim 1, it is characterized in that: in described endo-medicine, the weight portion of each component is the Radix Astragali 40～45 weight portions, Radix Polygoni Multiflori Preparata 25～30 weight portions, the Rhizoma Atractylodis Macrocephalae 35～40 weight portions, Flos Magnoliae 50～55 weight portions, the Radix Angelicae Dahuricae 45～50 weight portions, Ramulus Cinnamomi 20～25 weight portions, Herba Centipedae 20～25 weight portions, Radix Puerariae 10～15 weight portions, Radix Codonopsis 65～70 weight portions, Rhizoma Polygonati 35～40 weight portions, Pericarpium Citri Reticulatae 20～25 weight portions, Fructus Citri Sarcodactylis 15～20 weight portions, Herba Cistanches 35～40 weight portions, Semen Astragali Complanati 30～35 weight portions, Herba Ecliptae 30～35 weight portions, Poria 10～15 weight portions, Radix Aconiti Lateralis Preparata 10～15 weight portions, Cortex Cinnamomi 10～15 weight portions,

3. Chinese medicine composition as claimed in claim 1, it is characterized in that: in described endo-medicine, the weight portion of each component is the Radix Astragali 35～45 weight portions, Radix Polygoni Multiflori Preparata 20～30 weight portions, the Rhizoma Atractylodis Macrocephalae 30～40 weight portions, Flos Magnoliae 45～55 weight portions, the Radix Angelicae Dahuricae 40～50 weight portions, Ramulus Cinnamomi 15～25 weight portions, Herba Centipedae 15～25 weight portions, Radix Puerariae 10～20 weight portions, Radix Codonopsis 60～70 weight portions, Rhizoma Polygonati 30～40 weight portions, Pericarpium Citri Reticulatae 15～25 weight portions, Fructus Citri Sarcodactylis 10～20 weight portions, Herba Cistanches 30～40 weight portions, Semen Astragali Complanati 25～35 weight portions, Herba Ecliptae 25～35 weight portions, Poria 10～20 weight portions, Radix Aconiti Lateralis Preparata 10～20 weight portions, Cortex Cinnamomi 10～20 weight portions,

In described external used medicine, the weight portion of each component is Flos Magnoliae 60～65 weight portions, the Radix Angelicae Dahuricae 40～45 weight portions, Radix Scrophulariae 15～20 weight portions, Fructus Gardeniae 25～30 weight portions, Herba Houttuyniae 15～20 weight portions, Rhizoma Gastrodiae 10～15 weight portions, Periostracum Cicadae 30～35 weight portions, Radix Rhodiolae 15～20 weight portions, Radix Curcumae 15～20 weight portions, Fructus Piperis Longi 15～20 weight portions, Rhizoma Acori Graminei 10～15 weight portions, Fructus Aurantii Immaturus 25～30 weight portions, Folium Et Cacumen Murrayae 20～25 weight portions, Rhizoma Phragmitis 30～35 weight portions, the Rhizoma Anemarrhenae 35～40 weight portions, Rhizoma Coptidis 40～45 weight portions, Fructus Anisi Stellati 10～15 weight portions.

4. Chinese medicine composition as claimed in claim 1, is characterized in that: in described endo-medicine, the weight portion of each component is the Radix Astragali 40 weight portions, Radix Polygoni Multiflori Preparata 25 weight portions, the Rhizoma Atractylodis Macrocephalae 35 weight portions, Flos Magnoliae 50 weight portions, the Radix Angelicae Dahuricae 45 weight portions, Ramulus Cinnamomi 20 weight portions, Herba Centipedae 20 weight portions, Radix Puerariae 10 weight portions, Radix Codonopsis 65 weight portions, Rhizoma Polygonati 35 weight portions, Pericarpium Citri Reticulatae 20 weight portions, Fructus Citri Sarcodactylis 15 weight portions, Herba Cistanches 35 weight portions, Semen Astragali Complanati 30 weight portions, Herba Ecliptae 30 weight portions, Poria 10 weight portions, Radix Aconiti Lateralis Preparata 10 weight portions, Cortex Cinnamomi 10 weight portions;

5. Chinese medicine composition as claimed in claim 1, is characterized in that: the dosage form of described endo-medicine is tablet, pin powder, capsule, oral liquid, granule, electuary, pill, powder, injection.

6. Chinese medicine composition as claimed in claim 1, is characterized in that: the dosage form of described external used medicine is unguentum, spray, patch, smear agent or tincture.

7. the preparation method of the described Chinese medicine composition of one of claim 1 to 5, is characterized in that: in the time that the dosage form of described endo-medicine is powder, comprises,

The first step, each component in described endo-medicine is all ground into 20 order～30 object powder, putting in proportion blender is uniformly mixed, add the water with respect to 2～4 times of mixture qualities, decoct 3～5 hours, decoction liquor is filtered, obtain the first filtrate, add the water with respect to 2～4 times of filtering residue quality by filtering the filtering residue obtaining, again decoct 3～5 hours, decoction liquor is filtered, obtain the second filtrate, the first filtrate and the second filtrate are mixed to acquisition mixed liquor, concentrated except anhydrating, obtain concentrated solution, the volume of the concentrated solution after concentrated is 1/4～1/5 of concentrated front mixed liquor,

Second step, in concentrated solution, adding determining alcohol is that 80%～90% ethanol is to reaching more than 80% containing alcohol amount, at 4 DEG C, cold preservation 24 hours, leaches precipitation, reclaims ethanol, concentrated, dry, obtain and get dry extract, put into super micron mill and pulverize, obtain 200 order～300 object ultra-micro powders, be endo-medicine powder.

8. the preparation method of the described Chinese medicine composition of one of claim 1 to 5, is characterized in that: in the time that the dosage form of described endo-medicine is oral liquid, it comprises,

Second step, in concentrated solution, add determining alcohol be 80%～90% ethanol to reaching more than 80% containing alcohol amount, cold preservation 24 hours at 4 DEG C, with the centrifugal rear acquisition supernatant of high speed centrifuge, add the A Siba of 0.01～0.03 times of mixture quality of the original components obtaining with respect to the first step sweet, the sucrose of 0.01～0.03 times, adds water to enough subsequently, stir, filter, embedding in 10ml oral liquid bottle, 100 DEG C of sterilizings 30 minutes, packaging, to obtain final product.

9. the preparation method of the described Chinese medicine composition of one of claim 1 to 5, is characterized in that: when the dosage form of described external used medicine is spray, it comprises,

The first step, each component in described external used medicine is all ground into 20 order～30 object powder, putting in proportion blender is uniformly mixed, add the water with respect to 2～4 times of mixture qualities, decoct 3～5 hours, decoction liquor is filtered, obtain the first filtrate, add the water with respect to 2～4 times of filtering residue quality by filtering the filtering residue obtaining, again decoct 3～5 hours, decoction liquor is filtered, obtain the second filtrate, the first filtrate and the second filtrate are mixed to acquisition mixed liquor, concentrated except anhydrating, obtain concentrated solution, the volume of the concentrated solution after concentrated is 1/4～1/5 of concentrated front mixed liquor,

Second step, in concentrated solution, add determining alcohol be 80%～90% ethanol to reaching more than 80% containing alcohol amount, cold preservation 24 hours, leaches precipitation at 4 DEG C, reclaim ethanol, concentrated, dry, obtain and get dry extract, put into super micron mill and pulverize, obtain 200 order～300 object ultra-micro powders;

The 3rd step, the ultra-micro powder that second step is obtained is placed in the water with respect to 3～5 times of its quality, stirring and dissolving, to be dissolvedly add with respect to this solution quality 5% surfactant polyethylene 400 quantitative separatings in aerosol pressure vessel after completely, be pushed down into 2 times of volume propellant tetrafluoroethane in the condition of 100Kpa again, make spray.