CN106236927A - A kind of Chinese medicine composition with enhancing immunity and antifatigue effect and preparation method thereof and purposes - Google Patents
A kind of Chinese medicine composition with enhancing immunity and antifatigue effect and preparation method thereof and purposes Download PDFInfo
- Publication number
- CN106236927A CN106236927A CN201610626693.4A CN201610626693A CN106236927A CN 106236927 A CN106236927 A CN 106236927A CN 201610626693 A CN201610626693 A CN 201610626693A CN 106236927 A CN106236927 A CN 106236927A
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- China
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- radix
- chinese medicine
- medicine composition
- schisandrae chinensis
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Classifications
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/258—Panax (ginseng)
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- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/254—Acanthopanax or Eleutherococcus
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/57—Magnoliaceae (Magnolia family)
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- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/79—Schisandraceae (Schisandra family)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
- A61K36/815—Lycium (desert-thorn)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
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- C12G—WINE; PREPARATION THEREOF; ALCOHOLIC BEVERAGES; PREPARATION OF ALCOHOLIC BEVERAGES NOT PROVIDED FOR IN SUBCLASSES C12C OR C12H
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- C12G3/04—Preparation of other alcoholic beverages by mixing, e.g. for preparation of liqueurs
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- A—HUMAN NECESSITIES
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Abstract
The invention belongs to medicine or field of health care products, be specifically related to a kind of Chinese medicine composition with enhancing immunity and antifatigue effect and preparation method thereof and purposes.The crude drug composition of this Chinese medicine composition includes: Radix Ginseng 20～60 weight portion, Fructus Lycii 120～280 weight portion, Radix Et Caulis Acanthopanacis Senticosi 60～180 weight portion, Fructus Schisandrae Chinensis 10～30 weight portion.Chinese medicine composition of the present invention, take into full account each Chinese medicine return through and nature and flavor, and select each Chinese medicine proportioning each other, make each Chinese medicine cooperate according to compatibility relationship, jointly act on, thus play enhancing immunity and antifatigue effect；Chinese medicine composition of the present invention, composition is simple, cost is relatively low.
Description
Technical field
The invention belongs to medicine or field of health care products, be specifically related to a kind of to have in enhancing immunity and antifatigue effect
Drug composition and preparation method thereof and purposes.
Background technology
Modern society, the pathogenetic underlying causes of a lot of diseases be hypoimmunity or immunity unsound.Human immunity system
Unite perfect, then body is harmonious, healthy；Otherwise body is impaired, show as easy infection or easy sick state.
Immunity refers to a kind of specific physiological reaction of body contact " antigenicity foreign body " or " dissident's composition ".Immune system
To maintaining, body normal physiological function is significant.When not enough (protein, vitamin, the trace unit of people's Nutrition intake
Element etc. lack) time Abwehrkraft des Koepers can be caused to decline, cause immunocompetence to reduce, to immunologic mechanism generation harmful effect.Immunity
System is made up of immune organ, immunocyte and immune molecule.Immune organ, according to their effect, can be divided into central immune device
Official and peripheral immune organ；Immunocyte refers to all participation immunne response or the cell relevant with immunne response and predecessor thereof,
Including hematopoietic cell, lymphocyte etc..The cell performing inherent immunity function has phagocyte, NK cell (natural killer cell)
Deng, perform adaptive immunity function has T lymphocyte and bone-marrow-derived lymphocyte, and various immunocytes both originate from hematopoietic stem cell.
The immunologic function of human body includes the natural immunity (nonspecific immunity) and acquired immunity (specific immunity) two
Point.Specific immunity and nonspecific immunity have close relationship.On the basis of the former is built upon the latter, and increase greatly
Strong the latter's removing function to specific pathogen or antigenicity substance, significantly improves body defenses function.Immunologic function is machine
Body gradual perfection and the result of evolution, wherein nonspecific immunity is the basis that biology is depended on for existence.
Fatigue is a comprehensive physiological process relating to many Physiology and biochemistry factors, is that human body is mental or physical exertion
A kind of normal physiological phenomenon necessarily occurred during to certain phase, it both indicated the original ability to work of body temporary transient under
Fall, is probably again body and develops into a tendency of sick and wounded state.Human body feels tired, although unlike cancer, heart disease etc. are come
Gesture is swift and violent, directly and promptly causes death, but it endangers, as a kind of, the stealthy killer that modern is healthy, has a strong impact on
The work of people and life, considerably increase sub-health population quantity.Under human body is chronically at fatigue state, can produce the oldest
First declining and fatigue syndrome, overfatigue even can accelerate death.
Chinese patent literature CN101612327A discloses: a kind of health promoting wine, several Chinese medicines obtain in liquor, described
Chinese medicine includes Radix Ginseng, Fructus Lycii, Radix Glycyrrhizae, Radix Et Caulis Acanthopanacis Senticosi, Radix Polygoni Multiflori Preparata, Radix Schisandrae Bicoloris etc., can strengthen body immunity and resistance.
But, above-mentioned composition exists and forms the shortcomings such as complicated, relatively costly, thus limits its application.
Therefore, study that novel therapeutic effect is good, toxic and side effects is little, it is simple to form, lower-cost there is enhancing immunity
The medicine of power and antifatigue effect is significant.
Summary of the invention
Therefore, the present invention provide one to treat therapeutic effect is good, toxic and side effects is little, it is simple to form, lower-cost have
Enhancing immunity and the Chinese medicine composition of antifatigue effect, and then its preparation method and purposes are provided.
For solving above-mentioned technical problem, the present invention is achieved through the following technical solutions:
The present invention provides a kind of Chinese medicine composition with enhancing immunity and antifatigue effect, its crude drug composition bag
Include:
Radix Ginseng 20～60 weight portion, Fructus Lycii 120～280 weight portion, Radix Et Caulis Acanthopanacis Senticosi 60～180 weight portion, Fructus Schisandrae Chinensis 10～
30 weight portions.
Preferably, the above-mentioned Chinese medicine composition with enhancing immunity and antifatigue effect of the present invention, its crude drug forms
Including:
Radix Ginseng 30～50 weight portion, Fructus Lycii 160～240 weight portion, Radix Et Caulis Acanthopanacis Senticosi 90～150 weight portion, Fructus Schisandrae Chinensis 15～
25 weight portions.
It is further preferred that the above-mentioned Chinese medicine composition with enhancing immunity and antifatigue effect of the present invention, its raw material
Medicine composition includes:
Radix Ginseng 40 weight portion, Fructus Lycii 200 weight portion, Radix Et Caulis Acanthopanacis Senticosi 120 weight portion, Fructus Schisandrae Chinensis 20 weight portion；Or
Radix Ginseng 30 weight portion, Fructus Lycii 240 weight portion, Radix Et Caulis Acanthopanacis Senticosi 90 weight portion, Fructus Schisandrae Chinensis 25 weight portion；Or
Radix Ginseng 50 weight portion, Fructus Lycii 160 weight portion, Radix Et Caulis Acanthopanacis Senticosi 150 weight portion, Fructus Schisandrae Chinensis 15 weight portion；Or
Radix Ginseng 38 weight portion, Fructus Lycii 210 weight portion, Radix Et Caulis Acanthopanacis Senticosi 109 weight portion, Fructus Schisandrae Chinensis 16 weight portion.
It is further preferred that the above-mentioned Chinese medicine composition with enhancing immunity and antifatigue effect of the present invention, also include
Spirit 500～1000 parts by volume, described weight portion is g/mL with the relation of parts by volume.
It is further preferred that the above-mentioned Chinese medicine composition with enhancing immunity and antifatigue effect of the present invention, described steaming
Evaporating wine is 717 parts by volume.
It is further preferred that the above-mentioned Chinese medicine composition with enhancing immunity and antifatigue effect of the present invention, described steaming
Evaporating wine is vodka or China white wine, and the number of degrees of described Spirit are 35～45 °.
It is further preferred that the above-mentioned Chinese medicine composition with enhancing immunity and antifatigue effect of the present invention, described steaming
Evaporating wine is 40 ° of vodka or 40 ° of China white wines.
The present invention also provides for the preparation method of a kind of above-mentioned Chinese medicine composition with enhancing immunity and antifatigue effect,
Comprise the following steps:
Take the Radix Ginseng of selected weight portion, Fructus Lycii, Radix Et Caulis Acanthopanacis Senticosi and Fructus Schisandrae Chinensis, heating and refluxing extraction at least 1 time, add every time
The volumetric concentration of at least 1 weight times amount is at least the ethanol water of 10% and extracts at least 0.5 hour, filters, merging filtrate, dense
Being reduced to 50 DEG C of relative densities is 1.05-1.30, to obtain final product；Or
Taking the Radix Ginseng of selected weight portion, Fructus Lycii, Radix Et Caulis Acanthopanacis Senticosi and Fructus Schisandrae Chinensis, 40～60 DEG C are extracted at least 1 time, add every time
The volumetric concentration of at least 1 weight times amount is at least the ethanol water of 10% and extracts at least 1 day, filters, merging filtrate, is concentrated into
50 DEG C of relative densities are 1.05-1.30, to obtain final product.
Preferably, the preparation method of the above-mentioned Chinese medicine composition with enhancing immunity and antifatigue effect of the present invention, bag
Include following steps:
Take the Radix Ginseng of selected weight portion, Fructus Lycii, Radix Et Caulis Acanthopanacis Senticosi and Fructus Schisandrae Chinensis, heating and refluxing extraction 2～4 times, add 2 every time
～4 weight times amount volumetric concentration 70～90% ethanol water extract 1～3 hour, filter, merging filtrate, be concentrated into 50
DEG C relative density is 1.05-1.30, to obtain final product；Or
Taking the Radix Ginseng of selected weight portion, Fructus Lycii, Radix Et Caulis Acanthopanacis Senticosi and Fructus Schisandrae Chinensis, 40～50 DEG C are extracted 2～4 times, add 2 every time
～4 the volumetric concentration of weight times amount be 70～90% ethanol water extract 5～10 days, filter, merging filtrate, be concentrated into 50
DEG C relative density is 1.05-1.30, to obtain final product.
It is further preferred that the preparation side of the above-mentioned Chinese medicine composition with enhancing immunity and antifatigue effect of the present invention
Method, comprises the following steps:
Take the Radix Ginseng of selected weight portion, Fructus Lycii, Radix Et Caulis Acanthopanacis Senticosi and Fructus Schisandrae Chinensis, heating and refluxing extraction 3 times, add 3 weights every time
The ethanol water of the volumetric concentration 80% of amount times amount extracts 2 hours, filters, and merging filtrate, being concentrated into 50 DEG C of relative densities is
1.05-1.30, to obtain final product；Or
Taking the Radix Ginseng of selected weight portion, Fructus Lycii, Radix Et Caulis Acanthopanacis Senticosi and Fructus Schisandrae Chinensis, 45 DEG C are extracted 3 times, add 3 times of weight every time
The ethanol water that volumetric concentration is 80% of amount extracts 7 days, filters, and merging filtrate, being concentrated into 50 DEG C of relative densities is 1.05-
1.30, to obtain final product.
It is further preferred that the preparation side of the above-mentioned Chinese medicine composition with enhancing immunity and antifatigue effect of the present invention
Method, further comprising the steps of: the crude drug of selected weight portion is crushed to powder.
The present invention also provides for the preparation method of a kind of above-mentioned Chinese medicine composition with enhancing immunity and antifatigue effect,
Comprise the following steps:
Take the Radix Ginseng of selected weight portion, Fructus Lycii, Radix Et Caulis Acanthopanacis Senticosi and Fructus Schisandrae Chinensis, add the Spirit of selected parts by volume, room temperature
Under airtight immersion 7～10 days, filter, to obtain final product；Or
Take the Radix Ginseng of selected weight portion, Fructus Lycii, Radix Et Caulis Acanthopanacis Senticosi and Fructus Schisandrae Chinensis, add the Spirit of selected parts by volume, 40
～airtight dipping 1～3 times at 50 DEG C, dipping 1～5 day every time, cooling, filter, merge impregnation liquid, to obtain final product；Or
Take the Radix Ginseng of selected weight portion, Fructus Lycii, Radix Et Caulis Acanthopanacis Senticosi and Fructus Schisandrae Chinensis, add the Spirit of selected parts by volume, micro-boiling
Extract 1～4 time, extract 1～3 hour every time, cooling, filter, united extraction liquid, to obtain final product.
It is further preferred that the preparation side of the above-mentioned Chinese medicine composition with enhancing immunity and antifatigue effect of the present invention
Method, comprises the following steps:
Take the Radix Ginseng of selected weight portion, Fructus Lycii, Radix Et Caulis Acanthopanacis Senticosi and Fructus Schisandrae Chinensis, add the Spirit of selected parts by volume, room temperature
Under airtight immersion 8 days, filter, to obtain final product；Or
Take the Radix Ginseng of selected weight portion, Fructus Lycii, Radix Et Caulis Acanthopanacis Senticosi and Fructus Schisandrae Chinensis, add the Spirit of selected parts by volume, 45
Airtight dipping 2 times at DEG C, every time dipping 3 days, cooling, filter, merge impregnation liquid, to obtain final product；Or
Take the Radix Ginseng of selected weight portion, Fructus Lycii, Radix Et Caulis Acanthopanacis Senticosi and Fructus Schisandrae Chinensis, add the Spirit of selected parts by volume, micro-boiling
Extract 2 times, extract 1.5 hours every time, cooling, filter, united extraction liquid, to obtain final product.
It is further preferred that the preparation side of the above-mentioned Chinese medicine composition with enhancing immunity and antifatigue effect of the present invention
Method, further comprising the steps of: by the crude drug of selected weight portion, to be crushed to powder.
During the present invention also provides for including the preparation of above-mentioned Chinese medicine composition or including that above-mentioned preparation method prepares
The preparation of drug composition,
Described Chinese medicine composition adds customary adjuvant, according to common process, makes the most acceptable tablet, capsule
Agent, powder, mixture, pill, granule, solution, syrup, soft extract, beverage, cookies, confection, cake or patch.
Described customary adjuvant is: filler, disintegrating agent, lubricant, suspending agent, binding agent, sweeting agent, correctives, anticorrosion
Agent, substrate etc..Filler includes: starch, pregelatinized Starch, lactose, mannitol, chitin, microcrystalline Cellulose, sucrose etc.；Collapse
Solution agent includes: starch, pregelatinized Starch, microcrystalline Cellulose, carboxymethyl starch sodium, crospolyvinylpyrrolidone, low replacement hydroxyl
Third cellulose, cross-linked carboxymethyl cellulose are received；Lubricant includes: magnesium stearate, sodium lauryl sulphate, Pulvis Talci, dioxy
SiClx etc.；Suspending agent includes: polyvinylpyrrolidone, microcrystalline Cellulose, sucrose, agar, hydroxypropyl methyl cellulose etc.；Bonding
Agent includes, starch slurry, polyvinylpyrrolidone, hydroxypropyl methyl cellulose etc.；Sweeting agent includes: saccharin sodium, Aspartane, sugarcane
Sugar, cyclamate, enoxolone etc.；Correctives includes: sweeting agent and various essence；Preservative includes: parabens, benzoic acid,
Sodium benzoate, sorbic acid and its esters, benzalkonium bromide, fixed, the eucalyptus oil of acetic acid chloroethene etc.；Substrate includes: PEG6000,
PEG4000, insect wax etc..
The present invention also provides for above-mentioned Chinese medicine composition, above-mentioned preparation method prepares Chinese medicine composition or above-mentioned in
The preparation of drug composition has the application in enhancing immunity and the medicine of antifatigue effect or health product in preparation.
Technical scheme has the advantage that
[Radix Ginseng] property is put down, and sweet in the mouth, micro-hardship return spleen channel, lung meridian, heart channel, have that strongly invigorating primordial QI, multiple arteries and veins be admittedly de-, invigorating the spleen to benefit the lung,
Effect of promoting the production of body fluid and inducing sedation of the mind, is mainly used in treating that impairment caused by overstrain is deficient, prolonged deficiency is multiple and the disease of QI and blood deficiency of body fluid.
[Fructus Lycii] property is put down, and sweet in the mouth is returned Liver Channel, kidney channel, had effect of nourishing the liver and kidney, replenishing vital essence to improve eyesight.
[Radix Et Caulis Acanthopanacis Senticosi] is warm in nature, acrid in the mouth, micro-hardship, returns Liver Channel, kidney channel, has effect of replenishing QI to invigorate the spleen, tonifying the kidney for tranquilization, is used for controlling
Treat the diseases such as body nihility power, inappetence, rheumatic arthralgia, soreness of waist and knee joint, muscles and bones contracture, insomnia and dreamful sleep.
[Fructus Schisandrae Chinensis] is warm in nature, sour in the mouth, returns lung meridian, kidney channel, heart channel, has nourishing kidney of astringing the lung, the arresting sweating that promotes the production of body fluid, arresting seminal emission antidiarrheal, peaceful
Heart and tranquilizing mind, supplementing QI for promoting the production of body fluid, the kidney invigorating are nourished heart, are restrained astringent or styptic treatment for spontaneous sweating effect, be mainly used in treatment impairment caused by overstrain is deficient, qi-blood-body fluid is not enough it
Disease.
Grain fermentation Chinese liquor has promoting blood circulation, the gas that keeps out the cold, warming middle-JIAO of being amusing, effect of row medicine gesture.
(1) Chinese medicine composition of the present invention, take into full account each Chinese medicine return through and nature and flavor, and select each Chinese medicine mutually it
Between proportioning, make each Chinese medicine cooperate according to compatibility relationship, jointly act on, have QI invigorating, nourish blood, effect of YIN nourishing, thus
Play enhancing immunity and antifatigue effect；
(2) medicated wine that Chinese medicine composition of the present invention is made, Spirit be preferably grain fermentation Chinese liquor, each crude drug with
Chinese liquor is dissolved in one, and under the effect of Chinese liquor, each raw material the effective elements of the medicine is all dissolved in Chinese liquor, and wine assisting drug, wine help medicine gesture
And give full play to its effect, so that this Chinese medicine composition has the effect of higher enhancing immunity and resisting fatigue；Additionally,
The medicated wine that this Chinese medicine composition is made, not only stability is higher, safety is higher, and prepares simplicity, good in taste；
(3) Chinese medicine composition of the present invention, composition is simple, cost is relatively low.
Detailed description of the invention
Embodiment 1
The crude drug of the Chinese medicine composition that the present embodiment has enhancing immunity and antifatigue effect consists of: Radix Ginseng 40g,
Fructus Lycii 200g, Radix Et Caulis Acanthopanacis Senticosi 120g, Fructus Schisandrae Chinensis 20g, 40 ° of vodka 717mL；
The preparation method of this Chinese medicine composition, comprises the following steps:
Take the Radix Ginseng of selected weight, Fructus Lycii, Radix Et Caulis Acanthopanacis Senticosi and Fructus Schisandrae Chinensis, be crushed to powder, add 40 ° of volts of selected volume
Spy adds, airtight immersion 8 days under room temperature, filters, to obtain final product；Or
Take the Radix Ginseng of selected weight, Fructus Lycii, Radix Et Caulis Acanthopanacis Senticosi and Fructus Schisandrae Chinensis, be crushed to powder, add 40 ° of volts of selected volume
Spy adds, airtight dipping 2 times at 45 DEG C, every time dipping 3 days, and cooling is filtered, and merges impregnation liquid, to obtain final product；Or
Take the Radix Ginseng of selected weight, Fructus Lycii, Radix Et Caulis Acanthopanacis Senticosi and Fructus Schisandrae Chinensis, be crushed to powder, add 40 ° of volts of selected volume
Spy adds, and micro-boiling is extracted 2 times, extracts 1.5 hours every time, and cooling is filtered, united extraction liquid, to be obtained final product.
Embodiment 2
The crude drug of the Chinese medicine composition that the present embodiment has enhancing immunity and antifatigue effect consists of:
Radix Ginseng 30g, Fructus Lycii 240g, Radix Et Caulis Acanthopanacis Senticosi 90g, Fructus Schisandrae Chinensis 25g；
The preparation method of this Chinese medicine composition, comprises the following steps:
Take the Radix Ginseng of selected weight, Fructus Lycii, Radix Et Caulis Acanthopanacis Senticosi and Fructus Schisandrae Chinensis, be crushed to powder, heating and refluxing extraction 2 times, often
The ethanol water of the volumetric concentration 70% of secondary addition 4 weight times amount extracts 3 hours, filters, merging filtrate, is concentrated into 50 DEG C of phases
It is 1.05-1.30 to density, to obtain final product；Or
Taking the Radix Ginseng of selected weight, Fructus Lycii, Radix Et Caulis Acanthopanacis Senticosi and Fructus Schisandrae Chinensis, be crushed to powder, 50 DEG C are extracted 2 times, add every time
The ethanol water that volumetric concentration is 70% entering 4 weight times amount extracts 10 days, filters, merging filtrate, is concentrated into 50 DEG C relatively
Density is 1.05-1.30, to obtain final product.
The present embodiment has the Chinese medicine composition of enhancing immunity and antifatigue effect and adds customary adjuvant, according to conventional work
Skill, makes capsule.
Embodiment 3
The crude drug of the Chinese medicine composition that the present embodiment has enhancing immunity and antifatigue effect consists of:
Radix Ginseng 50g, Fructus Lycii 160g, Radix Et Caulis Acanthopanacis Senticosi 150g, Fructus Schisandrae Chinensis 15g；
The preparation method of this Chinese medicine composition, comprises the following steps:
Take the Radix Ginseng of selected weight, Fructus Lycii, Radix Et Caulis Acanthopanacis Senticosi and Fructus Schisandrae Chinensis, be crushed to powder, heating and refluxing extraction 4 times, often
The ethanol water of the volumetric concentration 90% of secondary addition 2 weight times amount extracts 1 hour, filters, merging filtrate, is concentrated into 50 DEG C of phases
It is 1.05-1.30 to density, to obtain final product；Or
Taking the Radix Ginseng of selected weight, Fructus Lycii, Radix Et Caulis Acanthopanacis Senticosi and Fructus Schisandrae Chinensis, be crushed to powder, 40 DEG C are extracted 2 times, add every time
Enter 2 weight times amount the ethanol water that volumetric concentration is 90% extract 5 days, filter, merging filtrate, be concentrated into 50 DEG C the closeest
Degree is 1.05-1.30, to obtain final product.
The present embodiment has the Chinese medicine composition of enhancing immunity and antifatigue effect and adds customary adjuvant, according to conventional work
Skill, makes tablet.
Embodiment 4
The crude drug of the Chinese medicine composition that the present embodiment has enhancing immunity and antifatigue effect consists of:
Radix Ginseng 38g, Fructus Lycii 210g, Radix Et Caulis Acanthopanacis Senticosi 109g, Fructus Schisandrae Chinensis 16g；
The preparation method of this Chinese medicine composition, comprises the following steps:
Take the Radix Ginseng of selected weight, Fructus Lycii, Radix Et Caulis Acanthopanacis Senticosi and Fructus Schisandrae Chinensis, be crushed to powder, heating and refluxing extraction 3 times, often
The ethanol water of the volumetric concentration 88% of secondary addition 2.5 weight times amount extracts 2.4 hours, filters, merging filtrate, is concentrated into 50
DEG C relative density is 1.05-1.30, to obtain final product；Or
Taking the Radix Ginseng of selected weight, Fructus Lycii, Radix Et Caulis Acanthopanacis Senticosi and Fructus Schisandrae Chinensis, be crushed to powder, 48 DEG C are extracted 2 times, add every time
Enter 3 weight times amount the ethanol water that volumetric concentration is 88% extract 6 days, filter, merging filtrate, be concentrated into 50 DEG C the closeest
Degree is 1.05-1.30, to obtain final product.
The present embodiment has the Chinese medicine composition of enhancing immunity and antifatigue effect and adds customary adjuvant, according to conventional work
Skill, makes oral liquid.
Embodiment 5
The crude drug of the Chinese medicine composition that the present embodiment has enhancing immunity and antifatigue effect consists of:
Radix Ginseng 40g, Fructus Lycii 200g, Radix Et Caulis Acanthopanacis Senticosi 120g, Fructus Schisandrae Chinensis 20g；
The preparation method of this Chinese medicine composition, comprises the following steps:
Take the Radix Ginseng of selected weight, Fructus Lycii, Radix Et Caulis Acanthopanacis Senticosi and Fructus Schisandrae Chinensis, be crushed to powder, heating and refluxing extraction 3 times, often
The ethanol water of the volumetric concentration 80% of secondary addition 3 weight times amount extracts 2 hours, filters, merging filtrate, is concentrated into 50 DEG C of phases
It is 1.05-1.30 to density, to obtain final product；Or
Taking the Radix Ginseng of selected weight, Fructus Lycii, Radix Et Caulis Acanthopanacis Senticosi and Fructus Schisandrae Chinensis, be crushed to powder, 45 DEG C are extracted 3 times, add every time
Enter 3 weight times amount the ethanol water that volumetric concentration is 80% extract 7 days, filter, merging filtrate, be concentrated into 50 DEG C the closeest
Degree is 1.05-1.30, to obtain final product.
The present embodiment has the Chinese medicine composition of enhancing immunity and antifatigue effect and adds customary adjuvant, according to conventional work
Skill, makes powder.
Experimental example 1The research of the enhancing immunity effect of Chinese medicine composition of the present invention
1, experimental technique
The Rui Shi miscellaneous system mice of Military Medical Science Institute's supply, male and female half and half, body weight 18-20g；
The powder of embodiment 5 preparation；
Gastric infusion, each 0.5g, the next day once, 3 times a week, be administered after 2-3 week and detect.
Mice serum Lysozyme Levels determination experiment: added by serum in micrococcus luteus bacterium solution, in serum, lysozyme dissolves thin
Bacterium, causes the change of bacterium solution light transmittance, prepares standard curve simultaneously, find lysozyme concentration in serum.After being administered 2-3 week,
Taking mice serum, detect the activity of its serum lysozyme, observing medicine affects it.Specific experiment the results are shown in Table 1.
Macrophages in vitro phagocytosis experiment: take Turnover of Mouse Peritoneal Macrophages, make macrophage monolayer through adhesion.Then with
The ratio of 1:100 add staphylococcus aureus and3H-thymus pyrimidine (3H-TDR), 37 DEG C of cultivations, DNA of bacteria anabolism, mix
Enter3H-TDR becomes isotope labelling bacterium, and antibacterial is swallowed to intracellular simultaneously, after 30 minutes, through a series of process, measures cell
Interior isotope umber of pulse per minute (cpm), cpm is the highest, represents that cytophagy is the strongest.After being administered 2-3 week, obtain mice abdomen
Chamber macrophage, with3H-TdR incorporation methods, observes the impact of the phagocytic function on staphylococcus aureus.Specific experiment result is shown in
Table 2.
2, experimental result
The table 1 impact on mice serum bacterium enzyme level
As shown in Table 1, the medicated wine of embodiment 1 preparation has rising effect to the serum lysozyme level of mice.
The table 2 impact on macrophages in vitro phagocytic function
As shown in Table 2, the powder of embodiment 5 preparation makes mice that the external phagocytic function of macrophage is had certain enhancing
Effect.
In sum, Chinese medicine composition of the present invention has rising effect to the serum lysozyme level of mice, makes mice to huge
Phagocytal external phagocytic function has certain potentiation, can be as the medicine of potential enhancing immunity effect.
Experimental example 2The research of the antifatigue effect of Chinese medicine composition of the present invention
1, experimental technique
With male mice, body weight 25～28g, random packet, the 1st experimental group 10, the 2nd experimental group 10, matched group 10
Only.
1st experimental group, the 2nd experimental group gavage powder (based on crude drug) the 5g/kg/ day (10 times of embodiment 5 preparation respectively
Clinical dosage, LD50/10) and 10g/kg/ day (20 times of clinical dosages, Lg50/5), every day 1 time；Matched group gavages 0.5mL every day
Normal saline 1 time；Continue 24.From being administered the 4th, each treated animal soaks 3.5 hours at 25 DEG C～30 DEG C of deep water middle reaches every day
As stress, continue three weeks.It is administered the 25th day and carries out exercise tolerance experiment.Observe its swimming state during swimming test, change
Become time and judge its endurance.
Being put by mice in deep water, swim voluntarily, its nose, eye, the crown and ears are all exposed at the water surface, and two metapedes are struck, straight line
Swimming, shows that power is contained；Struck slowly such as two metapedes or do not drew, the water surface covers ears, and the submergence crown shows that power declines, and certainly enters water extremely
Time for declining is the animal movement endurance time.Each group mice is stress be after three weeks, and the measured endurance time is as shown in table 3.
2, experimental result
The table 3 impact on the Tolerance of Swimming time
As shown in Table 3, the swimming endurance time of the 1st experimental group, the swimming endurance time of the 2nd experimental group are all longer than matched group
The swimming endurance time, all have significant.This shows, the powder of embodiment 5 preparation can be remarkably reinforced Tolerance of Swimming,
There is antifatigue effect.
In sum, Chinese medicine composition of the present invention can be remarkably reinforced swimming endurance, has antifatigue effect, can be as latent
The medicine of resisting fatigue.
Obviously, above-described embodiment is only for clearly demonstrating example, and not restriction to embodiment.Right
For those of ordinary skill in the field, can also make on the basis of the above description other multi-form change or
Variation.Here without also cannot all of embodiment be given exhaustive.And the obvious change thus extended out or
Change among still in the protection domain of the invention.
Claims (14)
1. a Chinese medicine composition, it is characterised in that its crude drug composition includes:
Radix Ginseng 20～60 weight portion, Fructus Lycii 120～280 weight portion, Radix Et Caulis Acanthopanacis Senticosi 60～180 weight portion, Fructus Schisandrae Chinensis 10～30 weight
Amount part.
Chinese medicine composition the most according to claim 1, it is characterised in that its crude drug composition includes:
Radix Ginseng 30～50 weight portion, Fructus Lycii 160～240 weight portion, Radix Et Caulis Acanthopanacis Senticosi 90～150 weight portion, Fructus Schisandrae Chinensis 15～25 weight
Amount part.
Chinese medicine composition the most according to claim 2, it is characterised in that its crude drug composition includes:
Radix Ginseng 40 weight portion, Fructus Lycii 200 weight portion, Radix Et Caulis Acanthopanacis Senticosi 120 weight portion, Fructus Schisandrae Chinensis 20 weight portion；Or
Radix Ginseng 30 weight portion, Fructus Lycii 240 weight portion, Radix Et Caulis Acanthopanacis Senticosi 90 weight portion, Fructus Schisandrae Chinensis 25 weight portion；Or
Radix Ginseng 50 weight portion, Fructus Lycii 160 weight portion, Radix Et Caulis Acanthopanacis Senticosi 150 weight portion, Fructus Schisandrae Chinensis 15 weight portion；Or
Radix Ginseng 38 weight portion, Fructus Lycii 210 weight portion, Radix Et Caulis Acanthopanacis Senticosi 109 weight portion, Fructus Schisandrae Chinensis 16 weight portion.
4. according to the Chinese medicine composition described in any one of claim 1-3, it is characterised in that also include Spirit 500～1000
Parts by volume, described weight portion is g/mL with the relation of parts by volume.
Chinese medicine composition the most according to claim 4, it is characterised in that described Spirit is 717 parts by volume.
6. according to the Chinese medicine composition described in claim 4 or 5, it is characterised in that described Spirit is vodka or Chinese white
Wine, the number of degrees of described Spirit are 35～45 °.
Chinese medicine composition the most according to claim 6, it is characterised in that described Spirit is 40 ° of vodka or 40 ° of China
Chinese liquor.
8. the preparation method of the Chinese medicine composition described in an any one of claim 1-3, it is characterised in that include following step
Rapid:
Take the Radix Ginseng of selected weight portion, Fructus Lycii, Radix Et Caulis Acanthopanacis Senticosi and Fructus Schisandrae Chinensis, heating and refluxing extraction at least 1 time, add at least every time
The volumetric concentration of 1 weight times amount is at least the ethanol water of 10% and extracts at least 0.5 hour, filters, merging filtrate, is concentrated into
50 DEG C of relative densities are 1.05-1.30, to obtain final product；Or
Taking the Radix Ginseng of selected weight portion, Fructus Lycii, Radix Et Caulis Acanthopanacis Senticosi and Fructus Schisandrae Chinensis, 40～60 DEG C are extracted at least 1 time, add at least every time
The volumetric concentration of 1 weight times amount is at least the ethanol water of 10% and extracts at least 1 day, filters, merging filtrate, is concentrated into 50 DEG C
Relative density is 1.05-1.30, to obtain final product.
The preparation method of Chinese medicine composition the most according to claim 8, it is characterised in that comprise the following steps:
Take the Radix Ginseng of selected weight portion, Fructus Lycii, Radix Et Caulis Acanthopanacis Senticosi and Fructus Schisandrae Chinensis, heating and refluxing extraction 2～4 times, add 2～4 every time
The volumetric concentration 70 of weight times amount～the ethanol water of 90% extract 1～3 hour, filter, merging filtrate, are concentrated into 50 DEG C of phases
It is 1.05-1.30 to density, to obtain final product；Or
Taking the Radix Ginseng of selected weight portion, Fructus Lycii, Radix Et Caulis Acanthopanacis Senticosi and Fructus Schisandrae Chinensis, 40～50 DEG C are extracted 2～4 times, add 2～4 every time
The volumetric concentration of weight times amount be 70～90% ethanol water extract 5～10 days, filter, merging filtrate, be concentrated into 50 DEG C
Relative density is 1.05-1.30, to obtain final product.
The preparation method of Chinese medicine composition the most according to claim 9, it is characterised in that comprise the following steps:
Take the Radix Ginseng of selected weight portion, Fructus Lycii, Radix Et Caulis Acanthopanacis Senticosi and Fructus Schisandrae Chinensis, heating and refluxing extraction 3 times, add 3 times of weight every time
The ethanol water of the volumetric concentration 80% of amount extracts 2 hours, filters, and merging filtrate, being concentrated into 50 DEG C of relative densities is 1.05-
1.30, to obtain final product；Or
Taking the Radix Ginseng of selected weight portion, Fructus Lycii, Radix Et Caulis Acanthopanacis Senticosi and Fructus Schisandrae Chinensis, 45 DEG C are extracted 3 times, add 3 weight times amount every time
Volumetric concentration be 80% ethanol water extract 7 days, filter, merging filtrate, being concentrated into 50 DEG C of relative densities is 1.05-
1.30, to obtain final product.
The preparation method of the Chinese medicine composition described in 11. 1 kinds of any one of claim 4-7, it is characterised in that include following step
Rapid:
Take the Radix Ginseng of selected weight portion, Fructus Lycii, Radix Et Caulis Acanthopanacis Senticosi and Fructus Schisandrae Chinensis, add the Spirit of selected parts by volume, close under room temperature
Close immersion 7～10 days, filter, to obtain final product；Or
Take the Radix Ginseng of selected weight portion, Fructus Lycii, Radix Et Caulis Acanthopanacis Senticosi and Fructus Schisandrae Chinensis, add the Spirit of selected parts by volume, 40～50
Airtight dipping 1～3 times at DEG C, every time dipping 1～5 day, cooling, filter, merge impregnation liquid, to obtain final product；Or
Taking the Radix Ginseng of selected weight portion, Fructus Lycii, Radix Et Caulis Acanthopanacis Senticosi and Fructus Schisandrae Chinensis, add the Spirit of selected parts by volume, micro-boiling extracts 1
～4 times, extract 1～3 hour, cooling every time, filter, united extraction liquid, to obtain final product.
The preparation method of 12. Chinese medicine compositions according to claim 11, it is characterised in that comprise the following steps:
Take the Radix Ginseng of selected weight portion, Fructus Lycii, Radix Et Caulis Acanthopanacis Senticosi and Fructus Schisandrae Chinensis, add the Spirit of selected parts by volume, close under room temperature
Close immersion 8 days, filter, to obtain final product；Or
Take the Radix Ginseng of selected weight portion, Fructus Lycii, Radix Et Caulis Acanthopanacis Senticosi and Fructus Schisandrae Chinensis, add the Spirit of selected parts by volume, at 45 DEG C
Airtight dipping 2 times, every time dipping 3 days, cooling, filter, merge impregnation liquid, to obtain final product；Or
Taking the Radix Ginseng of selected weight portion, Fructus Lycii, Radix Et Caulis Acanthopanacis Senticosi and Fructus Schisandrae Chinensis, add the Spirit of selected parts by volume, micro-boiling extracts 2
Secondary, extract 1.5 hours, cooling every time, filter, united extraction liquid, to obtain final product.
13. preparations including the Chinese medicine composition described in any one of claim 1-7 or include any one of claim 8-12
The preparation of the Chinese medicine composition that described preparation method prepares, it is characterised in that
Described Chinese medicine composition adds customary adjuvant, according to common process, makes the most acceptable tablet, capsule, dissipates
Agent, mixture, pill, granule, solution, syrup, soft extract, beverage, cookies, confection, cake or patch.
Prepared by the Chinese medicine composition described in 14. any one of claim 1-7, the preparation method described in any one of claim 8-12
The preparation of the Chinese medicine composition described in the Chinese medicine composition obtained or claim 13 has enhancing immunity in preparation and resists tired
Application in the medicine of work or health product.
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| CN106728377A (en) * | 2016-12-26 | 2017-05-31 | 陈春祥 | A kind of three sons essence cream and preparation method thereof |
| CN109170878A (en) * | 2018-08-07 | 2019-01-11 | 北京筑元吉康医药科技有限责任公司 | A kind of health food of strengthen immunity and its application |
| WO2020233459A1 (en) * | 2019-05-17 | 2020-11-26 | 石家庄以岭药业股份有限公司 | Composition for improving memory and preparation method therefor |
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Application publication date: 20161221 |