CN102258628B - Chinese medicinal composition with lead removal promoting effect - Google Patents
Chinese medicinal composition with lead removal promoting effect Download PDFInfo
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- CN102258628B CN102258628B CN2011102020256A CN201110202025A CN102258628B CN 102258628 B CN102258628 B CN 102258628B CN 2011102020256 A CN2011102020256 A CN 2011102020256A CN 201110202025 A CN201110202025 A CN 201110202025A CN 102258628 B CN102258628 B CN 102258628B
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Abstract
The invention relates to a Chinese medicinal composition with the lead removal promoting effect, and aims to solve the problem of the raising of in-vivo lead content. In the technical scheme, the Chinese medicinal composition for promoting lead removal is prepared from the following Chinese herbal medicines in part by weight: 5 to 25 parts of Japanese climbing fern spore, 10 to 30 parts of mulberry fruit, 10 to 30 parts of chrysanthemum, 10 to 30 parts of Chinese wolfberry, 10 to 30 parts of Indian trum etflower seed, 10 to 30 parts of chaff flower root and 10 to 30 parts of green tangerine peel. The Chinese medicinal composition is low in preparation cost and small in toxic and side effects, and has the obvious effect of reducing blood lead, bone lead, liver lead and brain lead.
Description
Technical field
The invention belongs to the field of Chinese medicines, relate in particular to a kind of Chinese medicine composition that promotes lead-expelling function that has.
Background technology
Lead is a kind of human body non-essential element; It has very strong affinity to body tissue; And, upset the physiology combination of indispensable element in the human body and the balance of proportionate relationship, thereby upset the physiologically active of interior enzyme system of body and biomacromolecule through influencing the element of needed by human; Make in the body enzyme system lose normal physiological activity and other and regulate the equilibrated regulating action of body functions and get muddled, and then influence a plurality of systems of human body.Plumbous ideal concentration is zero in blood.Yet along with the acceleration of urbanization and process of industrialization, the environment lead contamination is on the rise, even has influence on human beings'health.Lead in the environment can get into human body through respiratory tract and skin, and is distributed in whole body with the plumbous form of phosphoric acid hydrogen, wherein has 90-95% to be converted into orthophosphate and is deposited in skeleton, tooth, internal organs, skin, the hair, transfers in the blood lentamente then.Each tissue system of human body all there is harm, wherein responsive to lead with nervous system and hemopoietic system.Be embodied in: influence the growth and the skeleton development of intelligence, cause dyspepsia and endocrine disturbance, cause anemia, hypertension and arrhythmia, destroy renal function and immunologic function etc.In addition, lead also has carcinogenic effect.
According to international children ' s lead poisoning diagnostic criteria (blood lead value>100ug/L); China's urban children lead poisoning prevalence rate is between 30%-40%; Part urban industry contaminated area nearly 100% even there is not the common urban district of obvious industrial pollution, also has the children blood lead of 10%-30% to exceed standard.Plumbous potential hazard to health causes people's attention day by day.
At present, preventing and treating saturnine basic principle is that environment intervention, health education and clinical treatment three combine, and the environment intervention is basic, and health education is a basic means, and the lead poisoning more than the moderate is just considered Drug therapy.The saturnine medicine of clinical treatment mainly contains calcium disodium chelate (CaNa2EDTA), sodium dimercaptosuccinate (DMSA) etc., can reduce lead load in the body though these medicines drive lead, and Plumbum removing is effective; But micro elements needed by human is run off; Also can cause damage to kidney, side effect is bigger, and drives nervous lesion that plumbous medicine causes lead and reverse and have little significance; So outside the medicine Plumbum removing a good appetite suddenly appearing in a serious disease severe lead poisoning, clinically generally do not adopt.
Summary of the invention
In order to overcome the above problems, the present invention provides the Chinese medicine composition of the promotion Plumbum removing that a kind of cost is low, Plumbum removing is effective, toxic and side effects is little.
The technical scheme that the present invention adopts is: a kind of Chinese medicine composition with promotion lead-eliminating effect, process by following raw material medicaments in part by weight proportioning
:
Spora Lygodii 5-25 part, Fructus Mori 10-30 part, Flos Chrysanthemi 10-30 part, Fructus Lycii 10-30 part,
Semen Oroxyli 10-30 part, Radix Achyranthis Bidentatae 10-30 part, Pericarpium Citri Reticulatae Viride 10-30 part.
Preferably, promote the Chinese medicine composition of lead-eliminating effect, process by following raw material medicaments in part by weight proportioning
:
8 parts of Spora Lygodii, 15 parts in Fructus Mori, 12 parts of Flos Chrysanthemis, 12 parts of Fructus Lyciis,
15 parts of Semen Oroxylis, 12 parts of Radix Achyranthis Bidentataes, 15 parts on Pericarpium Citri Reticulatae Viride.
The present invention is an effective ingredient with above-mentioned Chinese medicine composition, can be prepared into oral formulations by common process, like water decoction, oral liquid, capsule, tablet etc.
Preferred manufacturing procedure is following:
1) by above-mentioned weight portion proportioning, take by weighing each crude drug Spora Lygodii, Fructus Mori, Flos Chrysanthemi, Fructus Lycii, Semen Oroxyli, Radix Achyranthis Bidentatae and Pericarpium Citri Reticulatae Viride are subsequent use;
2) add Spora Lygodii, Fructus Mori, Flos Chrysanthemi, Fructus Lycii, Semen Oroxyli, 8-10 times of water gaging of Radix Achyranthis Bidentatae and green husk total weight soaked 2-3 hour, and heating decocts, and decoction liquor is filtered; Medicinal residues add 8-10 times of water gaging heating again, and decoction liquor is filtered, and filtrating merges, and gets supernatant;
When 3) supernatant concentration to relative density is 1.05-1.06, advance spray dryer, 140-160 ℃ of EAT control, leaving air temp 100-110 ℃, charging rate is 3-6 ml/ minute, gets spray drying powder.
Spray drying powder is further prepared oral liquid, capsule, tablet or electuary etc. by common process.
The invention has the beneficial effects as follows: with " record of Chinese pharmacopoeia,
Fructus Mori[nature and flavor] are sweet, sour, and are cold.[return through] GUIXIN, liver, kidney channel.[function cures mainly] YIN nourishing of enriching blood is promoted the production of body fluid and is moisturized.Be used for vertigo and tinnitus, palpitation and insomnia, early whitening of beard and hair, Tianjin wound is thirsty, and interior-heat is quenched one's thirst, blood deficiency and constipation.
Flos Chrysanthemi[nature and flavor] are sweet, bitter, are slightly cold.[return through] returned lung, Liver Channel.[function cures mainly] the wind heat clearing away of loosing, suppressing the hyperactive liver makes eye bright.Be used for anemopyretic cold, it is dizzy to have a headache, conjunctival congestion and swelling pain, and eyes is dim-sighted.
Fructus Lycii[nature and flavor] are sweet, and are flat.[return through] returned liver, kidney channel.[function cures mainly] nourishing the liver and kidney, replenishing vital essence to improve eyesight.Be used for the asthenia damage of essence, soreness of waist and knee joint, vertigo and tinnitus, interior-heat is quenched one's thirst, blood deficiency and yellow complexion, blurred vision is not clear.
Semen Oroxyli[nature and flavor] are bitter, sweet, cold.[return through] returned lung, liver, stomach warp.[function cures mainly] removing heat from the lung and relieving sorethroat, dispersing the stagnated liver-QI for regulating the stomach.Be used for the cough due to lung-heat, sore throat, hoarseness, stomachache due to hyperactive liver-QI attacking the stomach.
Radix Achyranthis Bidentatae[nature and flavor] are bitter, sour, and are flat.[return through] returned liver, kidney channel.[function cures mainly] invigorating the liver and kidney, bone and muscle strengthening, eliminating blood stasis and inducing menstruation, conducting blood to flow downwards.Be used for soreness of waist and knee joint, muscles and bones is unable, amenorrhea and mass in the abdomen, dizziness due to hyperactivity of liver-YANG.
Pericarpium Citri Reticulatae Viride[nature and flavor] are bitter, hot, temperature.[return through] returned liver, gallbladder, stomach warp.[function cures mainly] soothing the liver dispelling the stagnated QI, removing food stagnancyization stagnates.Be used for distending pain in the chest and hypochondrium, hernia, nodule in the breast, acute mastitis, abdominal pain due to retention of food.
Among the present invention, Fructus Mori, Fructus Lycii play the enhancing human body immunity effect, and Semen Oroxyli, Flos Chrysanthemi play the heat clearing away effect, and are rich in vitamin C etc., and Radix Achyranthis Bidentatae plays soothing the liver effect, and Pericarpium Citri Reticulatae Viride plays the circulation of qi promoting effect.Spora Lygodii and Fructus Mori, Fructus Lycii, Semen Oroxyli, Flos Chrysanthemi, Radix Achyranthis Bidentatae and Pericarpium Citri Reticulatae Viride science compatibility can reach promotion Plumbum removing, alleviation or prevention lead human body is damaged, improves the purpose of symptom, and have no side effect, and are suitable for the higher crowd of blood lead and take for a long time.Each raw material is easy to get among the present invention, and cost of manufacture is low, owing to adopt the Chinese crude drug of pure natural, so the toxic and side effects of goods is little.Through practice, Chinese medicine composition of the present invention has a tangible reduction effect to blood lead, bone are plumbous, liver is plumbous and brain is plumbous.
The specific embodiment
Embodiment 1Has the Chinese medicine composition that promotes lead-eliminating effect
(1) the raw material medicines in portions by weight proportioning is following:
Spora Lygodii 50 grams, Fructus Mori 100 grams, Flos Chrysanthemi 100 restrain, Fructus Lycii 100 restrains,
Semen Oroxyli 100 grams, Radix Achyranthis Bidentatae 100 grams, Pericarpium Citri Reticulatae Viride 100 grams;
(2) method for preparing is following:
1. get crude drug by above-mentioned weight portion proportioning;
2. add Spora Lygodii, Fructus Mori, Flos Chrysanthemi, Fructus Lycii, Semen Oroxyli, Radix Achyranthis Bidentatae and 8 times of water gagings of green husk total weight and soaked 2 hours, heating decocts, and after-filtration boils; Medicinal residues add 8 times of water gagings again and are heated to and boil, the after-filtration that boils, and filtrating merges, and is water decoction.
Embodiment 2Has the Chinese medicine composition that promotes lead-eliminating effect
(1) the raw material medicines in portions by weight proportioning is following
Spora Lygodii 250 grams, Fructus Mori 300 grams, Flos Chrysanthemi 300 restrain, Fructus Lycii 300 restrains,
Semen Oroxyli 300 grams, Radix Achyranthis Bidentatae 300 grams, Pericarpium Citri Reticulatae Viride 300 grams;
(2) method for preparing is following:
1. get crude drug by above-mentioned weight portion proportioning;
2. add Spora Lygodii, Fructus Mori, Flos Chrysanthemi, Fructus Lycii, Semen Oroxyli, Radix Achyranthis Bidentatae and 10 times of water gagings of green husk total weight and soaked 3 hours, heating decocts, and after-filtration boils; Medicinal residues add 10 times of water gagings again and are heated to and boil, the after-filtration that boils, filtrating merges, supernatant;
3. supernatant concentration to relative density is 1.05 o'clock, advances spray dryer, 140 ℃ of EAT controls, and 100 ℃ of leaving air temps, charging rate is 3ml/ minute, gets spray drying powder 180 grams.
With spray drying powder, can process oral formulations by common process, like oral liquid, capsule, tablet or electuary etc.
Embodiment 3Has the Chinese medicine composition that promotes lead-eliminating effect
(1) the raw material medicines in portions by weight proportioning is following
Spora Lygodii 80 grams, Fructus Mori 150 grams, Flos Chrysanthemi 120 restrain, Fructus Lycii 120 restrains,
Semen Oroxyli 150 grams, Radix Achyranthis Bidentatae 120 grams, Pericarpium Citri Reticulatae Viride 150 grams;
(2) method for preparing is following:
1. get crude drug by above-mentioned weight portion proportioning;
2. add Spora Lygodii, Fructus Mori, Flos Chrysanthemi, Fructus Lycii, Semen Oroxyli, Radix Achyranthis Bidentatae and 8 times of water gagings of green husk total weight and soaked 2 hours, heating decocts, and after-filtration boils; Medicinal residues add 8 times of water gagings again and are heated to and boil, the after-filtration that boils, filtrating merges, supernatant;
3. when supernatant concentration to relative density is 1.05-1.06, advance spray dryer, 140-160 ℃ of EAT control, leaving air temp 100-110 ℃, charging rate is 3-6 ml/ minute, gets spray drying powder 70 grams;
4. spray drying powder is pulverized, sieved, get fine powder;
With the fine powder that obtains, select adjuvant by prior art, mix, incapsulate, be Chinese medicinal composition capsules agent of the present invention.
Experimental example 1 Chinese medicine composition of the present invention promotes the lead-eliminating effect evaluation
Select 60 healthy Kunming mouses for use, cleaning level animal, male female half and half; Body weight 20 ± 2 grams are divided into 5 groups, i.e. the blank group; Dye plumbous model group, 3 dose groups of high, medium and low traditional Chinese medicine composition water decocting liquid, 12 every group; Lead acetate is dissolved in the distilled water by the 40mg/kg lumbar injection, sets up mice and dye plumbous animal model.
Get the water decoction of the foregoing description 1 preparation, as given the test agent; Dissolved in distilled water is the administration of various dose sample, and the various dose group comprises high dose group (30g/kg), middle dose groups (15g/kg); Low dose group (7.5g/kg); Each medication group gastric infusion, all the other each groups are irritated the normal saline of clothes equivalent, and the experiment successive administration is totally 8 weeks.Administration is got mice RFV blood 40ul after finishing, and puts into the plastic centrifuge tube with cover that fills 0.36ml1% nitric acid and shakes up; Get a side 50% femur, digest after weighing, add rare nitric acid and be settled to 5ml,, carry out blood and bone, liver and brain lead content mensuration with atomic spectrophotometer with corresponding liver and the cerebral tissue got of method; Above-mentioned data statistics is checked with T.
Table 1Traditional Chinese medicine composition water decocting liquid of the present invention is plumbous to mice blood lead, bone, liver and plumbous (mg/kg) content influence of brain (
± s, n=10)
The traditional Chinese medicine composition water decocting liquid is obvious to the blood lead content influence, and each dose groups and model group relatively have significant difference
P＜0.05; The traditional Chinese medicine composition water decocting liquid is influential to the bone lead content, and high dose group and model group relatively have significant difference
P＜0.05; Chinese medicine composition is obvious to the influence of liver lead content, and low middle high dose group and model group relatively have significant difference
P＜0.05; The traditional Chinese medicine composition water decocting liquid is obvious to the influence of brain lead content, and each dose groups and model group relatively have significant difference
P＜0.05.
Claims (4)
1. one kind has the Chinese medicine composition that promotes lead-eliminating effect, it is characterized in that being processed by following raw material medicaments in part by weight proportioning
:
Spora Lygodii 5-25 part, Fructus Mori 10-30 part, Flos Chrysanthemi 10-30 part, Fructus Lycii 10-30 part,
Semen Oroxyli 10-30 part, Radix Achyranthis Bidentatae 10-30 part, Pericarpium Citri Reticulatae Viride 10-30 part.
2. the Chinese medicine composition with promotion lead-eliminating effect according to claim 1 is characterized in that being processed by following raw material medicaments in part by weight proportioning
:
8 parts of Spora Lygodii, 15 parts in Fructus Mori, 12 parts of Flos Chrysanthemis, 12 parts of Fructus Lyciis,
15 parts of Semen Oroxylis, 12 parts of Radix Achyranthis Bidentataes, 15 parts on Pericarpium Citri Reticulatae Viride.
3. the method for preparing with the Chinese medicine composition that promotes lead-eliminating effect according to claim 1 and 2 is characterized in that comprising the steps:
1) by claim 1 or 2 described weight portion proportionings, take by weighing each crude drug Spora Lygodii, Fructus Mori, Flos Chrysanthemi, Fructus Lycii, Semen Oroxyli, Radix Achyranthis Bidentatae and Pericarpium Citri Reticulatae Viride are subsequent use;
2) add Spora Lygodii, Fructus Mori, Flos Chrysanthemi, Fructus Lycii, Semen Oroxyli, 8-10 times of water gaging of Radix Achyranthis Bidentatae and green husk total weight soaked 2-3 hour, and heating decocts, and decoction liquor is filtered; Medicinal residues add 8-10 times of water gaging heating again, and decoction liquor is filtered, and filtrating merges, and gets supernatant;
When 3) supernatant concentration to relative density is 1.05-1.06, advance spray dryer, 140-160 ℃ of EAT control, leaving air temp 100-110 ℃, charging rate is 3-6 ml/ minute, gets spray drying powder.
4. claim 1 or the 2 described Chinese medicine compositions application in the conventional oral formulations of preparation.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102727757B (en) * | 2012-07-06 | 2014-12-10 | 辽宁大学 | Application of Chinese Ladiestresses Root or Herb in preparation of either medicines or healthcare products capable of promoting lead-expelling effect |
| CN102935132B (en) * | 2012-09-04 | 2013-12-18 | 辽宁大学 | Lead removing traditional Chinese medicine composition |
| CN103976432A (en) * | 2014-04-17 | 2014-08-13 | 五河县鲲鹏食品饮料有限公司 | Lygodium japonicum (thunb.) sw lead-removing health beverage and preparation method thereof |
| CN107648376A (en) * | 2017-10-24 | 2018-02-02 | 宁国平衡健康管理有限公司 | A kind of solid beverage for promoting lead discharging and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101548993A (en) * | 2009-05-06 | 2009-10-07 | 辽宁大学 | Application of Japanese climbing fern spore in preparing lead excretion medicines or health products |
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| CN101548993A (en) * | 2009-05-06 | 2009-10-07 | 辽宁大学 | Application of Japanese climbing fern spore in preparing lead excretion medicines or health products |
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