CN100525801C - Application of plantain herb in preparing medicine and health article with lead removal promoting effect - Google Patents
Application of plantain herb in preparing medicine and health article with lead removal promoting effect Download PDFInfo
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- CN100525801C CN100525801C CNB2006100342042A CN200610034204A CN100525801C CN 100525801 C CN100525801 C CN 100525801C CN B2006100342042 A CNB2006100342042 A CN B2006100342042A CN 200610034204 A CN200610034204 A CN 200610034204A CN 100525801 C CN100525801 C CN 100525801C
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- herba plantaginis
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Abstract
The present invention discloses the new use of plantain in preparing medicine and health food with lead removal promoting effect. The medicine and health food is taken by high lead people.
Description
Technical field
The present invention relates to the purposes of a kind of raw material Herba Plantaginis of medicine-food two-purpose, is the medicine of lead-eliminating effect in preparation promotes body or the purposes of health product specifically.
Technical background
Lead is a kind of human body non-essential element, it has very strong affinity to body tissue, and by influencing the element of needed by human, upset the physiology combination of indispensable element in the human body and the balance of proportionate relationship, thereby the physiologically active of enzyme system and biomacromolecule in the upset body, making in the body enzyme system lose normal physiological activity and other regulates the equilibrated regulating action of body functions and gets muddled, and then influence a plurality of systems of human body, and as: nervous system, hemopoietic system, reproductive system, osseous tissue, kidney and liver etc.Wherein nervous system and blood-hemopoietic system are the most responsive to lead, often cause diseases such as peripheral neuritis, motion and paraesthesia; Lead enters cerebral tissue with blood flow, also can damage cerebellum and brain cortex cell, disturb metabolic activity, cause nutrient substance and oxygen supply deficiency, thereby symptoms such as headache, hypomnesis, insomnia appear, also often with gastrointestinal symptoms such as inappetence, gastroenteritis, stomachache.
Lead is a kind of nondegradable environmental contaminants, is prevalent in natural atmosphere, soil, water and the food, easily is absorbed by the body by digestive tract, respiratory tract.Its is put aside in each tissue of human body, and is wherein maximum with the skeleton amount of savings, accounts for and puts aside 85%～90% of lead in the body.
In the daily life, the child is plumbous acute sufferer, and main cause is as follows: the one, and poor because the child resists the energy force rate adult of lead poisoning evil; The 2nd, because child's living habit, height characteristics etc. cause the lead ratio adult who takes in by digestive tract and respiratory tract many; The 3rd, because child's blood brain barrier is grown imperfection, permeability is big, and the child takes in intravital lead in daily life has 30% to stay in the blood, blood lead is easy to see through blood brain barrier brain is produced murder by poisoning, as untimely removing, along with the growth of blood brain barrier is perfect, the lead that storage is stayed in the brain is difficult to get rid of, and may cause child's brain permanent lesion and mental retardation.
Many studies show that is when child's blood lead concentration〉during 4.8umol/L, can irreversible infringement take place to its IQ.But this does not also occur tangible clinical symptoms often.On a large amount of research bases, 1991 American National Center for Disease Control (CDC) (CDC) on the basis of a large amount of clinical and epidemiologic datas, determine that the diagnostic criteria of children ' s lead poisoning is: blood lead concentration 〉=4.8umol/L.No matter whether corresponding symptom and other blood and chemical change are arranged, this standard is accepted by the various countries scholar, certainly children ' s lead poisoning described here is not represented the poisoning on the clinical meaning, but lead load has been in the danger level that impairs children's health in the expression body.
Preventing and treating saturnine basic principle is the environment intervention, health education and clinical treatment three combine, the environment intervention is basic, health education is a basic means, and to being that the lead poisoning of blood lead concentration 〉=0.9umol/L is just considered Drug therapy more than the moderate, this is because the medicine of clinical treatment mainly contains calcium disodium chelate (CaNa2EDTA) at present, sodium dimercaptosuccinate (DMSA) etc., though driving lead, medicine can reduce lead load in the body, Plumbum removing is effective, but micro elements needed by human is run off, also can cause damage to kidney, side effect is bigger, and drive nervous lesion that plumbous medicine causes lead and reverse and have little significance, so outside the medicine Plumbum removing a good appetite suddenly appearing in a serious disease severe lead poisoning, clinically generally do not adopt.
Chinese invention patent publication number CN102293A once disclosed " compositions that contains Herba Plantaginis ", adopt the compositions of the similar nougat that contains Herba Plantaginis fiber and almond paste, and these compositionss was as the purposes of laxative and/or cholesterol reducing.Chinese invention patent publication number CN1173339A once disclosed " Chinese wolfberry type Health Oral Liquid ", adopt structure Fructus Lycii, Herba Plantaginis, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Cinnabaris, Radix Salviae Miltiorrhizae, Radix Polygalae, Flos Carthami and Arillus Longan, common senile disease such as Comprehensive Treatment cardiovascular diseases, neurasthenia, insomnia, amnesia.
Herba Plantaginis is the dry herb of Plantaginaceae plant Herba Plantaginis Plantago asiatica L or Plantago depressa Willd Plantago depressa Wild., has advantages such as cheap, as to enrich, have no side effect in the medicine source.Chinese medicine thinks that it has clearing away heat to improve acuity of vision, and clearing away heat and promoting diuresis is eliminated the phlegm, removing heat from blood, antidotal effect; Clinical foreign body sensation and pain in the eye commonly used, inducing diuresis for treating stranguria syndrome, antitussive is relievingd asthma, and eliminates the phlegm; Modern pharmacological research proves that it can increase intestinal propulsion speed, plays slow effect of letting out by increasing the intestinal volume, and gastric juice is had dual regulation, and in addition, Herba Plantaginis is to acute pyelonephritis, active type hepatitis, and prostatic hyperplasia has certain therapeutical effect.Do not see bibliographical information but whether Herba Plantaginis has the human body of promotion lead-eliminating effect.
Summary of the invention
The object of the invention provides Herba Plantaginis or its extract promotes the medicine of lead-eliminating effect or the application in the health product in preparation.
Adopt Herba Plantaginis or its extract as raw material, single with or make up routinely formulation method with Fructus Lycii and can be prepared into and be fit to oral any dosage form, as tablet, capsule, electuary, oral liquid, chewable tablet etc., and health product.
The present invention is that screening obtains having the Herba Plantaginis that clearly promotes lead-eliminating effect from medicine and food raw materials, can reach and promote the plumbous purpose of human body being damaged, improves symptom of Plumbum removing, alleviation or prevention, and have no side effect, be suitable for the higher crowd of blood lead and take for a long time, especially at the child.
The specific embodiment
The invention will be further elaborated below in conjunction with embodiment.
Embodiment 1
Select 60 healthy Kunming mouses for use, cleaning level animal, male female half and half, body weight 20 ± 2 grams are divided into 5 groups, it is the blank group, dye plumbous model group, 3 dosage groups of high, medium and low Herba Plantaginis decocting liquid, 12 every group, lead acetate is dissolved in the distilled water by the 40mg/kg lumbar injection, sets up mice and dye plumbous animal model.
Herba Plantaginis decocting liquid adopts conventional decocting method preparation, and simmer down to respective concentration, decocting liquid various dose group comprises high dose group (9g/kg), middle dosage group (6g/kg), low dose group (3g/kg), each medication group gastric infusion, all the other each groups gavage the normal saline of equivalent, and the experiment successive administration is totally 8 weeks.Administration is got mice right femoral vein blood 40ul after finishing, and puts into the plastic centrifuge tube with cover that fills 0.36ml1% nitric acid and shakes up; Get a side 50% femur, digest after weighing, add rare nitric acid and be settled to 5ml, with corresponding liver and the cerebral tissue got of method, with atomic spectrophotometer carry out blood and bone, liver, the brain lead content is measured; Above-mentioned data statistics is checked with T.
Table 1 Herba Plantaginis decocting liquid to mice blood lead, bone lead, liver and brain lead (mg/kg) content influence (x ± s, n=10)
nCompare P＜0.05 with model group
hCompare P＜0.01 with the blank group
Herba Plantaginis decocting liquid is obvious to the blood lead content influence, and middle high dose group and model group relatively have significant difference P＜0.05; Herba Plantaginis decocting liquid is obvious to the influence of bone lead content, and low middle high dose group and model group relatively have significant difference P＜0.05; Herba Plantaginis decocting liquid is obvious to the influence of liver lead content, and low middle high dose group and model group relatively have significant difference P＜0.05-0.01; Herba Plantaginis decocting liquid is obvious to the influence of brain lead content, and high dose group and model group relatively have significant difference P＜0.05.
Embodiment 2
Select 60 healthy Kunming mouses for use, a cleaning level animal, male female half and half, body weight 20 ± 2 grams; Animal is divided into 5 groups, and promptly the blank group is dyed plumbous model group, 3 dosage groups of high, medium and low Herba Plantaginis decocting liquid, and 12 every group, lead acetate is dissolved in the distilled water by the 40mg/kg lumbar injection, set up mice and dye plumbous animal model.
Take by weighing Herba Plantaginis and Fructus Lycii by same weight proportion, adopt conventional decocting method to prepare Herba Plantaginis Fructus Lycii decocting liquid, and simmer down to respective concentration, each medication group gastric infusion, the various dose group comprises high dose group (9g/kg), middle dosage group (6g/kg), and low dose group (3g/kg) is gastric infusion respectively, all the other each groups gavage the equivalent normal saline, and the experiment successive administration is totally 6 weeks.Administration is got mice right femoral vein blood 40ul after finishing, and puts into the plastic centrifuge tube with cover that fills 0.36ml1% nitric acid and shakes up; Get a side 50% femur, digest after weighing, add rare nitric acid and be settled to 5ml, with corresponding liver and the cerebral tissue got of method, with atomic spectrophotometer carry out blood and bone, liver, the brain lead content is measured; Above-mentioned data statistics is checked with T.
Table 1 Herba Plantaginis Fructus Lycii decocting liquid to mice blood lead, bone lead, liver and brain lead (mg/kg) content influence (x ± s, n=10)
aCompare P＜0.05 with model group
bCompare P＜0.01 with the blank group
Herba Plantaginis Fructus Lycii decocting liquid is obvious to the blood lead content influence, and middle high dose group and model group relatively have significant difference P＜0.05; Herba Plantaginis Fructus Lycii decocting liquid is obvious to the influence of bone lead content, and low middle high dose group and model group relatively have significant difference P＜0.05; Herba Plantaginis Fructus Lycii decocting liquid is obvious to the influence of liver lead content, and low middle high dose group and model group relatively have significant difference P＜0.05-0.01; Herba Plantaginis Fructus Lycii decocting liquid is obvious to the influence of brain lead content, and middle high dose group and model group relatively have significant difference P＜0.05.
Claims (4)
1, a kind of medicine that promotes lead-eliminating effect is characterized in that: by Herba Plantaginis or its extract, with structure Qi co-production.
2, medicine according to claim 1 is characterized in that: dosage form is an oral formulations.
3, a kind of health product that promote lead-eliminating effect is characterized in that: by Herba Plantaginis or its extract, with the Fructus Lycii co-production.
4, health product according to claim 3 is characterized in that: dosage form is an oral formulations.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2006100342042A CN100525801C (en) | 2006-03-10 | 2006-03-10 | Application of plantain herb in preparing medicine and health article with lead removal promoting effect |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2006100342042A CN100525801C (en) | 2006-03-10 | 2006-03-10 | Application of plantain herb in preparing medicine and health article with lead removal promoting effect |
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| Publication Number | Publication Date |
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| CN1857656A CN1857656A (en) | 2006-11-08 |
| CN100525801C true CN100525801C (en) | 2009-08-12 |
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Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104147146B (en) * | 2014-08-28 | 2017-01-25 | 四川圣湖生物科技有限公司 | Pharmaceutical composition capable of promoting excretion of lead, and preparation method and application thereof |
| CN105211364A (en) * | 2015-09-17 | 2016-01-06 | 云南滇红集团股份有限公司 | There is the Asiatic plantain Pu'er tea of lead-eliminating effect |
| CN109965287A (en) * | 2019-04-16 | 2019-07-05 | 湖南泽迈生物科技有限公司 | A kind of formula and preparation method of re-scheduling metal health care product |
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- 2006-03-10 CN CNB2006100342042A patent/CN100525801C/en not_active Expired - Fee Related
Non-Patent Citations (2)
| Title |
|---|
| 枸杞多糖对染铅小鼠脑功能的保护作用. 蔡宇，陈冰，余绍蕾，张荣华.中国公共卫生，第21卷第12期. 2005 |
| 枸杞多糖对染铅小鼠脑功能的保护作用. 蔡宇，陈冰，余绍蕾，张荣华.中国公共卫生，第21卷第12期. 2005 * |
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