CN101288683A - Application of roselle for preparing health product for promoting lead-eliminating effect - Google Patents
Application of roselle for preparing health product for promoting lead-eliminating effect Download PDFInfo
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- CN101288683A CN101288683A CNA2008100287114A CN200810028711A CN101288683A CN 101288683 A CN101288683 A CN 101288683A CN A2008100287114 A CNA2008100287114 A CN A2008100287114A CN 200810028711 A CN200810028711 A CN 200810028711A CN 101288683 A CN101288683 A CN 101288683A
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Abstract
The invention discloses a new application of roselle in the preparation of health products with an effect for facilitating lead excretion. Roselle has non-toxic side effects, which can be produced to be any form of oral health products according to the conventional methods of preparation by combining with other drugs that has the effect for facilitating lead excretion or exclusive use; wherein, other drugs with the effect for facilitating lead excretion contain one or more of the followings, such as Chinese wolfberry, sun-plant, tuckahoe, salvia miltiorrhiza, atractylodes, alisma orientalis and so on. The product is suitable for people of high blood lead to take for long-term and children with high blood lead.
Description
Technical field
The raw material that the present invention relates to is the Chinese medicine Calyx Hibisci Sabdariffae, is the purposes in preparing the health product that promote lead-eliminating effect in the body specifically.
Background technology
Lead is broad-spectrum toxic metals, is used for metallurgy more, accumulator, printing, pottery, industries such as paint pharmacy.Mainly with steam, forms such as dirt powder and smog enter human body by the respiratory tract digestive tract.From the biochemistry angle, lead is a kind of poisonous mineral with affinity, and it is very long to enter the interior back half-life of body, is about 1460 days.It is distributed in whole body with the form of phosphoric acid hydrogen lead earlier, wherein has 90-95% to be converted into orthophosphate and is deposited in skeleton, tooth, internal organs, skin, the hair, transfers in the blood lentamente then.Human body such as lead content are too much, not only can cause hypomnesis, and thinking and judgment are blunt, anemia, and digestive functional disturbance, psychoplegia, even also can bring out cancer etc.
Along with the acceleration of Chinese Urbanization and process of industrialization, the environment lead contamination is on the rise.In daily life and work, all can touch lead unavoidably, and be subjected to the harm of lead contamination.What wherein, the child was subjected to has the greatest impact.Infer according to the expert, nearly 20 years, China's urbanite's Pb-B is ascendant trend year by year, according to international children ' s lead poisoning diagnostic criteria (blood lead value＞100ug/L), China's urban children lead poisoning prevalence rate is between 30%-40%, part urban industry contaminated area nearly 100% even there is not the common urban district of obvious industrial pollution, also has the children blood lead of 10%-30% to exceed standard.
Plumbous potential hazard to health causes people's attention day by day.At present, preventing and treating saturnine basic principle is that environment intervention, health education and clinical treatment three combine, and the environment intervention is basic, and health education is a basic means, and to being that the lead poisoning of blood lead concentration 〉=0.9umol/L is just considered Drug therapy more than the moderate.The saturnine medicine of clinical treatment mainly contains calcium disodium chelate (CaNa2EDTA), sodium dimercaptosuccinate (DMSA), thousand fruit flowers, thousand acute hearing etc., though driving lead, these medicines can reduce lead load in the body, Plumbum removing is effective, but micro elements needed by human is run off, also can cause damage to kidney, side effect is bigger, and drive nervous lesion that plumbous medicine causes lead and reverse and have little significance, so outside the medicine Plumbum removing a good appetite suddenly appearing in a serious disease severe lead poisoning, clinically generally do not adopt, must under doctor's guidance, take during use.Also have some by dietetic therapy or Chinese medicine Plumbum removing, and obtained certain curative effect, can increase protein and methionine as the food of rich in proteins thing, saturnine symptom can effectively be prevented and alleviate to the intake of sulfur-containing amino acid such as cystine; The abundant food of food, iron content that contains high calcium can reduce plumbously to be accumulated in that the people is intravital, and can prevent the anemia due to the lead poisoning.In addition, Folium Camelliae sinensis contains materials such as tannic acid, can be combined into solable matter with intravital lead and excrete with urine, and Bulbus Allii also has the effect of Plumbum removing.These foods can be used for prevention or treatment is light, the moderate lead poisoning.
Calyx Hibisci Sabdariffae (English: Roselle, Jamaica sorrel; Latin: Hibiscus sabdariffaL.), claim Hibiscus Sabdariffa Linn again, roselle, red sorrel, Lip river Ji certain herbaceous plants with big flowers, be Malvaceae Hibiscus annual herb plant or perennial shrub, grow in the torrid zone and subtropical zone, originate in West Africa, India, distribution is all arranged in Guangdong, Guangxi, Fujian, the Yunnan of China.Its sour in the mouth has the effect of refrigerant pathogenic fire reducing, promoting the production of body fluid to quench thirst.All effective in cure to diseases such as cardiovascular, arteriosclerosis, hypertension, fracture, bad, the old dyspepsia of childhood development, achlorhydria.And can be used for skin care, drive away summer heat, relieve the effect of alcohol.Can be used to brew tea and make beverage, also can extract the Calyx Hibisci Sabdariffae pigment, as the food additive of food service industry.Do not see bibliographical information but whether Calyx Hibisci Sabdariffae has the human body of promotion lead-eliminating effect.
Chinese invention patent publication number CN1250628A once disclosed " health tea and preparation method thereof ", adopt preparation health teas such as Folium Camelliae sinensis, Semen Nelumbinis, Radix Morindae Officinalis, Fructus Jujubae, Radix Glycyrrhizae, Fructus Lycii, Herba Epimedii, Flos Carthami powder, Calyx Hibisci Sabdariffae powder, be applicable to after being ill that body void, chamber are unable, oldaged physically weak, women puerperal etc., drink and to make people's body constitution strong, energetic.Do not mention the effect of Plumbum removing in its function.Chinese invention patent publication number CN1404740A once disclosed " a kind of eight-ingredients slim tea and manufacture method ", employing selects for use Radix Panacis Quinquefolii, Calyx Hibisci Sabdariffae, Radix Polygoni Multiflori, Fructus Lycii, Herba Potentillae Discoloris, Fructus Crataegi, Radix Glycyrrhizae, oolong tea etc. eight flavor Chinese herbal medicine and tea to prepare health tea, has heat-clearing and toxic substances removing is arranged, promoting the production of body fluid to quench thirst, nourishing the liver and kidney, replenishing vital essence to improve eyesight, lowering blood-fat and reducing weight, skin maintenance, diuresis relieving constipation, life prolonging effect.The also effect of not mentioned Plumbum removing in its function.
Summary of the invention
The object of the invention provides Calyx Hibisci Sabdariffae or the application of its extract in the health product of preparation promotion lead-eliminating effect.
Adopt Calyx Hibisci Sabdariffae or its extract as raw material, single with or with other drug regimens with lead-eliminating effect routinely formulation method can be prepared into the health product that are fit to oral any dosage form.Wherein other medicines with lead-eliminating effect comprise one or more in Fructus Lycii, Fructus Lycii, Herba Portulacae Grandiflorae, Poria, Radix Salviae Miltiorrhizae, Rhizoma Atractylodis, the Rhizoma Alismatis etc.
The present invention is that screening obtains having the Calyx Hibisci Sabdariffae that clearly promotes lead-eliminating effect from Chinese medicine, can reach and promote the plumbous purpose of human body being damaged, improves symptom of Plumbum removing, alleviation or prevention, and have no side effect, be suitable for the higher crowd of blood lead and take for a long time, also be suitable for the higher child of blood lead.
The specific embodiment
The invention will be further elaborated below in conjunction with embodiment.
Embodiment 1 Calyx Hibisci Sabdariffae is to dying 50 the healthy Kunming mouses that influence of plumbous mice blood lead, bone lead, liver and brain lead content, cleaning level, male female half and half, body weight 18-22 gram is divided into 5 groups, i.e. the blank group, dye plumbous model group, 3 dosage groups of high, medium and low Calyx Hibisci Sabdariffae decocting liquid, 10 every group.Lead acetate is dissolved in the distilled water by the 40mg/kg lumbar injection, sets up mice and dye plumbous animal model.
Calyx Hibisci Sabdariffae decocting liquid adopts conventional decocting method preparation, and simmer down to respective concentration, decocting liquid various dose group comprises high dose group (15g/kg), middle dosage group (7.5g/kg), low dose group (3.8g/kg), gastric infusion is respectively organized in medication, and all the other each groups gavage the normal saline of equivalent, and the experiment successive administration is totally 6 weeks.Administration is got mice right femoral vein blood 40ul after finishing, and puts into the plastic centrifuge tube with cover that fills 0.36ml 1% nitric acid and shakes up; Get a side 50% femur, digest after weighing, add rare nitric acid and be settled to 5ml, with corresponding liver and the cerebral tissue got of method, with atomic spectrophotometer carry out blood and bone, liver, the brain lead content is measured; Above-mentioned data statistics is checked with T.
Table 1 Calyx Hibisci Sabdariffae decocting liquid to mice blood lead, bone lead, liver and brain lead (mg/kg) content influence (
± s, n=12)
aCompare P＜0.05 with model group
bCompare P＜0.01 with the blank group
Calyx Hibisci Sabdariffae decocting liquid can obviously reduce and dyes plumbous mice blood lead content, and wherein middle and high dosage Calyx Hibisci Sabdariffae decocting liquid lead-eliminating effect is obvious, and blood lead content and model group comparing difference have the significance meaning, P＜0.05; Calyx Hibisci Sabdariffae decocting liquid is fairly obvious to bone lead content influence, and basic, normal, high dosage all has the effect of significance to the reduction of bone lead, and medication group mice bone lead content and model group relatively have significant difference, P＜0.05; Calyx Hibisci Sabdariffae decocting liquid also can obviously reduce the lead that dyes in plumbous mouse liver and the brain, and each medication group Mouse Liver lead content and brain lead content and model group Mouse Liver lead, brain lead content comparing difference all have the significance meaning, P＜0.05.
Embodiment 2 Calyx Hibisci Sabdariffae Fructus Lycii decocting liquid are to mice blood lead, bone lead, liver and brain lead (mg/kg) content influence
50 healthy Kunming mouses, cleaning level, male female half and half, body weight 18-22 gram; Animal is divided into 5 groups, and promptly the blank group is dyed plumbous model group, 3 medication groups of high, medium and low dosage, and 10 every group, lead acetate is dissolved in the distilled water by the 40mg/kg lumbar injection, set up mice and dye plumbous animal model.
Take by weighing Calyx Hibisci Sabdariffae and Fructus Lycii in 1: 1 ratio, adopt conventional decocting method to prepare Calyx Hibisci Sabdariffae Fructus Lycii decocting liquid, and simmer down to respective concentration, each medication group gastric infusion, the various dose group comprises high dose group (20.0g/kg), middle dosage group (10.0g/kg), and low dose group (5.0g/kg) is gastric infusion respectively, all the other each groups gavage the equivalent normal saline, and the experiment successive administration is totally 6 weeks.Administration is got mice right femoral vein blood 40ul after finishing, and puts into the plastic centrifuge tube with cover that fills 0.36ml 1% nitric acid and shakes up; Get a side 50% femur, digest after weighing, add rare nitric acid and be settled to 5ml, with corresponding liver and the cerebral tissue got of method, with atomic spectrophotometer carry out blood and bone, liver, the brain lead content is measured; Above-mentioned data statistics is checked with T.
Table 2 Calyx Hibisci Sabdariffae Fructus Lycii decocting liquid to mice blood lead, bone lead, liver and brain lead (mg/kg) content influence (
± s, n=12)
aCompare P＜0.05 with model group
bCompare P＜0.01 with the blank group
Calyx Hibisci Sabdariffae Fructus Lycii decocting liquid can obviously reduce and dyes plumbous mice blood lead, bone lead, liver lead and brain lead content, wherein the effect of high dose decocting liquid is obvious, high dose group mice blood lead, bone lead, liver lead and brain lead content and model group mice blood lead, bone lead, liver lead and the apparent in view reduction of brain lead content, difference has the significance meaning, P＜0.05.
Claims (3)
1, Calyx Hibisci Sabdariffae or its extract list are used or are promoted lead-eliminating effect medicines to promote the medicine of lead-eliminating effect or the application in the health product in preparation with other.
2, purposes according to claim 1 is characterized in that: one or more in Calyx Hibisci Sabdariffae or its extract and Fructus Lycii, Folium Ginkgo, Herba Portulacae Grandiflorae, Poria, Radix Salviae Miltiorrhizae, Rhizoma Atractylodis, the Rhizoma Alismatis are made the health product that promote lead-eliminating effect jointly.
3, purposes according to claim 1 is characterized in that: described health product are oral formulations.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2008100287114A CN101288683A (en) | 2008-06-03 | 2008-06-03 | Application of roselle for preparing health product for promoting lead-eliminating effect |
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| Application Number | Priority Date | Filing Date | Title |
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| CNA2008100287114A CN101288683A (en) | 2008-06-03 | 2008-06-03 | Application of roselle for preparing health product for promoting lead-eliminating effect |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102389516A (en) * | 2011-11-21 | 2012-03-28 | 上海市第二中学 | Pharmaceutical composition for treating lead poisoning, preparation method and application thereof |
| CN102727757A (en) * | 2012-07-06 | 2012-10-17 | 辽宁大学 | Application of Chinese Ladiestresses Root or Herb in preparation of either medicines or healthcare products capable of promoting lead-expelling effect |
-
2008
- 2008-06-03 CN CNA2008100287114A patent/CN101288683A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102389516A (en) * | 2011-11-21 | 2012-03-28 | 上海市第二中学 | Pharmaceutical composition for treating lead poisoning, preparation method and application thereof |
| CN102727757A (en) * | 2012-07-06 | 2012-10-17 | 辽宁大学 | Application of Chinese Ladiestresses Root or Herb in preparation of either medicines or healthcare products capable of promoting lead-expelling effect |
| CN102727757B (en) * | 2012-07-06 | 2014-12-10 | 辽宁大学 | Application of Chinese Ladiestresses Root or Herb in preparation of either medicines or healthcare products capable of promoting lead-expelling effect |
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Open date: 20081022 |