CN102935132B - Lead removing traditional Chinese medicine composition - Google Patents
Lead removing traditional Chinese medicine composition Download PDFInfo
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- CN102935132B CN102935132B CN 201210459212 CN201210459212A CN102935132B CN 102935132 B CN102935132 B CN 102935132B CN 201210459212 CN201210459212 CN 201210459212 CN 201210459212 A CN201210459212 A CN 201210459212A CN 102935132 B CN102935132 B CN 102935132B
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- 239000003814 drug Substances 0.000 title claims abstract description 43
- 239000000203 mixture Substances 0.000 title claims abstract description 27
- 239000002994 raw material Substances 0.000 claims abstract description 10
- 235000003956 Luffa Nutrition 0.000 claims abstract description 3
- 241001125229 Oldenlandia hedyotidea Species 0.000 claims abstract description 3
- WABPQHHGFIMREM-UHFFFAOYSA-N lead(0) Chemical compound [Pb] WABPQHHGFIMREM-UHFFFAOYSA-N 0.000 claims description 13
- 241000594394 Hedyotis Species 0.000 claims description 11
- 238000002360 preparation method Methods 0.000 claims description 6
- 241001299723 Limonia <Rutaceae> Species 0.000 claims description 2
- 241000219138 Luffa Species 0.000 claims description 2
- 238000009472 formulation Methods 0.000 claims description 2
- 230000000694 effects Effects 0.000 abstract description 11
- 239000008280 blood Substances 0.000 abstract description 10
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- 231100000331 toxic Toxicity 0.000 abstract description 3
- 230000002588 toxic effect Effects 0.000 abstract description 3
- 238000004519 manufacturing process Methods 0.000 abstract description 2
- 235000005979 Citrus limon Nutrition 0.000 abstract 1
- 244000131522 Citrus pyriformis Species 0.000 abstract 1
- 241000675108 Citrus tangerina Species 0.000 abstract 1
- 244000050983 Luffa operculata Species 0.000 abstract 1
- 230000001603 reducing effect Effects 0.000 abstract 1
- 230000000630 rising effect Effects 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 17
- 229940079593 drug Drugs 0.000 description 11
- 206010027439 Metal poisoning Diseases 0.000 description 6
- 238000009835 boiling Methods 0.000 description 6
- 238000001914 filtration Methods 0.000 description 6
- 208000008127 lead poisoning Diseases 0.000 description 6
- 239000007788 liquid Substances 0.000 description 6
- 239000000843 powder Substances 0.000 description 6
- 238000001694 spray drying Methods 0.000 description 6
- 239000006228 supernatant Substances 0.000 description 6
- 238000010438 heat treatment Methods 0.000 description 5
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- 239000000706 filtrate Substances 0.000 description 4
- 239000010903 husk Substances 0.000 description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 239000007921 spray Substances 0.000 description 3
- 208000024891 symptom Diseases 0.000 description 3
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- 241000699670 Mus sp. Species 0.000 description 2
- GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical compound O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 description 2
- 239000002671 adjuvant Substances 0.000 description 2
- 230000017531 blood circulation Effects 0.000 description 2
- 239000002775 capsule Substances 0.000 description 2
- 230000002490 cerebral effect Effects 0.000 description 2
- 230000004087 circulation Effects 0.000 description 2
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- 239000012153 distilled water Substances 0.000 description 2
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- 230000002496 gastric effect Effects 0.000 description 2
- 229910017604 nitric acid Inorganic materials 0.000 description 2
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- 206010000087 Abdominal pain upper Diseases 0.000 description 1
- SHWNNYZBHZIQQV-UHFFFAOYSA-J EDTA monocalcium diisodium salt Chemical compound [Na+].[Na+].[Ca+2].[O-]C(=O)CN(CC([O-])=O)CCN(CC([O-])=O)CC([O-])=O SHWNNYZBHZIQQV-UHFFFAOYSA-J 0.000 description 1
- 208000005577 Gastroenteritis Diseases 0.000 description 1
- 206010019233 Headaches Diseases 0.000 description 1
- 206010062717 Increased upper airway secretion Diseases 0.000 description 1
- 238000012449 Kunming mouse Methods 0.000 description 1
- 241000699666 Mus <mouse, genus> Species 0.000 description 1
- 208000001738 Nervous System Trauma Diseases 0.000 description 1
- 206010029240 Neuritis Diseases 0.000 description 1
- 206010029350 Neurotoxicity Diseases 0.000 description 1
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 206010044221 Toxic encephalopathy Diseases 0.000 description 1
- RXDLGFMMQFNVLI-UHFFFAOYSA-N [Na].[Na].[Ca] Chemical compound [Na].[Na].[Ca] RXDLGFMMQFNVLI-UHFFFAOYSA-N 0.000 description 1
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- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
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- 230000007812 deficiency Effects 0.000 description 1
- 229940070748 dimercaptosuccinate Drugs 0.000 description 1
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- 229910001385 heavy metal Inorganic materials 0.000 description 1
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- 235000015097 nutrients Nutrition 0.000 description 1
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- BCWRXLLYMXFJDY-UHFFFAOYSA-M sodium;4-hydroxy-4-oxo-2,3-bis(sulfanyl)butanoate Chemical compound [Na+].OC(=O)C(S)C(S)C([O-])=O BCWRXLLYMXFJDY-UHFFFAOYSA-M 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
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Landscapes
- Medicines Containing Plant Substances (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention relates to a lead removing traditional Chinese medicine composition to solve the problem of rising of lead content in the body. The technical scheme is that the traditional Chinese medicine composition capable of promoting lead removing is made of the following raw materials according to weight: 5-25 parts of lemon peels, 5-25 parts of banian leaves, 10-30 parts of luffa stems, 5-20 parts of spora lygodii, 10-30 parts of hedyotis hedyotidea and 5-30 parts of green tangerine peels. The lead removing traditional Chinese medicine composition is low in production cost, small in toxic and side effect and obvious in blood lead, bone lead, liver lead and brain lead reducing effects.
Description
Technical field
The invention belongs to the field of Chinese medicines, relate in particular to a kind of Chinese medicine composition that promotes lead-expelling function that has.
Background technology
Lead is commercial Application heavy metal widely, very strong to the affinity of tissue, can cause the multiple organ injury diseases such as liver, brain, with nervous system injury more so, often causes the diseases such as peripheral neuritis, motion and paraesthesia.Enter cerebral tissue if plumbous with blood flow, can damage cerebellum and brain cortex cell, disturb metabolic activity, cause nutrient substance and oxygen supply deficiency, thereby the symptoms such as headache, hypomnesis, insomnia appear, also often with gastrointestinal symptoms such as inappetence, gastroenteritis, stomachache.Plumbous at the occurring in nature ubiquity, human health in the lead contamination in the life such as living environment also serious harm.
Lead poisoning is day by day serious to the health hazard of Chinese children, and according to international children ' s lead poisoning diagnostic criteria (blood lead value > 100ug/L), the child that the city blood lead exceeds standard at present has more than 30%, and the neurotoxicity infringement of lead poisoning is irreversible.Plumbous to healthy potential hazard, day by day cause people's concern.
At present, preventing and treating saturnine basic principle is that environment intervention, health education and clinical treatment three combine, and the environment intervention is basic, and health education is basic means, and the above lead poisoning of alignment degree is just considered Drug therapy.The saturnine medicine of clinical treatment mainly contains calcium disodium chelate (CaNa2EDTA), sodium dimercaptosuccinate (DMSA) etc., though driving lead, these medicines can reduce lead load in body, Plumbum removing is effective, but can make micro elements needed by human run off, also can cause damage to kidney, side effect is larger, and drives nervous lesion that plumbous medicine causes lead and reverse and have little significance, so, outside medicine Plumbum removing a good appetite suddenly appearing in a serious disease severe lead poisoning, clinically generally do not adopt.For current lead poisoning hazard present situation, from Chinese medicine (especially medicine and food raw materials), the appropriate proportioning of the suitable Chinese crude drug of screening, have fine promotion lead-eliminating effect.
Summary of the invention
In order to overcome the above problems, the invention provides the Chinese medicine composition of the promotion Plumbum removing that a kind of cost is low, Plumbum removing is effective, toxic and side effects is little.
The technical solution used in the present invention is: a kind of Plumbum removing Chinese medicine composition, by following raw material medicaments in part by weight proportioning, made
:fericarpium Citri Limoniae 5-25 part, Folium fici microcarpae 5-25 part, Ramulus Luffae 10-30 part, Spora Lygodii 5-20 part, Caulis et Folium hedyotis hedyotideae 10-30 part, Pericarpium Citri Reticulatae Viride 5-30 part.
Preferably, the Plumbum removing Chinese medicine composition, made by following raw material medicaments in part by weight proportioning
:9 parts of Fericarpium Citri Limoniaes, 12 parts of Folium fici microcarpaes, 15 parts of Ramulus Luffaes, 9 parts of Spora Lygodii, 12 parts of Caulis et Folium hedyotis hedyotideaes, 9 parts, Pericarpium Citri Reticulatae Viride.
The present invention be take above-mentioned Chinese medicine composition as effective ingredient, and technique is prepared into oral formulations routinely, as water decoction, oral liquid, capsule, tablet etc.
Preferred preparation method is as follows:
1), by above-mentioned weight portion proportioning, take each crude drug Fericarpium Citri Limoniae, Folium fici microcarpae, Ramulus Luffae, Spora Lygodii, Caulis et Folium hedyotis hedyotideae, Pericarpium Citri Reticulatae Viride standby;
2) add Fericarpium Citri Limoniae, Folium fici microcarpae, Ramulus Luffae, Spora Lygodii, Caulis et Folium hedyotis hedyotideae and 8-10 times of water gaging of green husk total weight and soak 2-3 hour, heating decocts, and decoction liquor is filtered; Medicinal residues add 6-8 times of water gaging heating again, and decoction liquor is filtered, and filtrate merges, and obtains supernatant;
When 3) supernatant concentration to relative density is 1.05-1.08, advance spray dryer, inlet temperature is controlled 140-160 ℃, leaving air temp 100-110 ℃, and charging rate is 3-6 ml/ minute, obtains spray drying powder.
By spray drying powder further routinely technique prepare oral liquid, capsule, tablet or electuary etc.
The invention has the beneficial effects as follows: Fericarpium Citri Limoniae, sour in the mouth, suffering, micro-hardship, warm in nature, there is the circulation of qi promoting stomach function regulating effect of eliminating the phlegm; Folium fici microcarpae, lightly seasoned, cool in nature, there is heat-clearing toxin-expelling functions; Ramulus Luffae, bitter in the mouth, cold nature, have the promoting blood circulation to remove obstruction in the collateral effect; Spora Lygodii, bitter in the mouth, cool in nature, there is the eliminating damp-heat effect; Caulis et Folium hedyotis hedyotideae, bitter in the mouth, cool in nature, there is the clearing heat and expelling damp effect; Pericarpium Citri Reticulatae Viride, sour in the mouth, have circulation of qi promoting blood stasis dispelling effect.Above-mentioned medical material science compatibility, can reach and promote Plumbum removing, alleviation or prevention lead to damage, improve the purpose of symptom human body, and have no side effect, and is suitable for the higher crowd's long-term taking of blood lead.In the present invention, each raw material is easy to get, and cost of manufacture is low, and due to the Chinese crude drug that adopts pure natural, so the toxic and side effects of goods is little.Through practice, Chinese medicine composition of the present invention has an obvious reduction effect to blood lead, bone are plumbous, liver is plumbous and brain is plumbous.
The specific embodiment
embodiment 1 Plumbum removing Chinese medicine composition
(1) the raw material medicines in portions by weight proportioning is as follows:
Fericarpium Citri Limoniae 50 grams, Folium fici microcarpae 50 grams, Ramulus Luffae 100 grams, Spora Lygodii 50 grams, Caulis et Folium hedyotis hedyotideae 100 grams, Pericarpium Citri Reticulatae Viride 50 grams.
(2) preparation method is as follows:
1. get crude drug by above-mentioned weight portion proportioning;
2. add Fericarpium Citri Limoniae, Folium fici microcarpae, Ramulus Luffae, Spora Lygodii, Caulis et Folium hedyotis hedyotideae, 8 times of water gagings of green husk total weight to soak 2 hours, heating decocts, the rear filtration of boiling; Medicinal residues add 6 times of water gagings again and are heated to boil, the rear filtration of boiling, and filtrate merges, and is water decoction.
embodiment 2 Plumbum removing Chinese medicine compositions
(1) the raw material medicines in portions by weight proportioning is as follows
Fericarpium Citri Limoniae 90 grams, Folium fici microcarpae 120 grams, Ramulus Luffae 150 grams, Spora Lygodii 90 grams, Caulis et Folium hedyotis hedyotideae 120 grams, Pericarpium Citri Reticulatae Viride 90 grams.
(2) preparation method is as follows:
1. get crude drug by above-mentioned weight portion proportioning;
2. add Fericarpium Citri Limoniae, Folium fici microcarpae, Ramulus Luffae, Spora Lygodii, Caulis et Folium hedyotis hedyotideae, 9 times of water gagings of green husk total weight to soak 3 hours, heating decocts, the rear filtration of boiling; Medicinal residues add 7 times of water gagings again and are heated to boil, the rear filtration of boiling, and filtrate merges, and obtains supernatant;
3. supernatant concentration to relative density is 1.06 o'clock, advances spray dryer, and inlet temperature is controlled 150 ℃, 105 ℃ of leaving air temps, and charging rate is 5ml/ minute, obtains spray drying powder 30 grams;
4. spray drying powder is added to adjuvant and mix, sieve, tabletting, be prepared into tablet.
embodiment 3 Plumbum removing Chinese medicine compositions
(1) the raw material medicines in portions by weight proportioning is as follows
Fericarpium Citri Limoniae 250 grams, Folium fici microcarpae 250 grams, Ramulus Luffae 300 grams, Spora Lygodii 200 grams, Caulis et Folium hedyotis hedyotideae 300 grams, Pericarpium Citri Reticulatae Viride 300 grams.
(2) preparation method is as follows:
1. get crude drug by above-mentioned weight portion proportioning;
2. add Fericarpium Citri Limoniae, Folium fici microcarpae, Ramulus Luffae, Spora Lygodii, Caulis et Folium hedyotis hedyotideae, 10 times of water gagings of green husk total weight to soak 3 hours, heating decocts, the rear filtration of boiling; Medicinal residues add 8 times of water gagings again and are heated to boil, the rear filtration of boiling, and filtrate merges, and obtains supernatant;
3. supernatant concentration to relative density is 1.06 o'clock, advances spray dryer, and inlet temperature is controlled 150 ℃, 105 ℃ of leaving air temps, and charging rate is 5ml/ minute, obtains spray drying powder 80 grams;
4. spray drying powder is added to adjuvant and mix, sieve, granulate, encapsulated.
experimental example 1 Chinese medicine composition of the present invention promotes the lead-eliminating effect evaluation
50 of the healthy Kunming mouses of clean level, male female half and half, body weight 20 ± 2 grams, be divided into 5 groups, the blank group, dye plumbous model group, 3 dosage groups of high, medium and low traditional Chinese medicine composition water decocting liquid, every group 10, lead acetate is dissolved in distilled water by the 40mg/kg lumbar injection, set up mice and dye plumbous animal model.
Get the water decoction of above-described embodiment 1 preparation, as given the test agent; Distilled water is dissolved as the administration of various dose sample, and the various dose group comprises high dose group (30g/kg), middle dosage group (15g/kg), low dose group (7.5g/kg), each medication group gastric infusion, all the other each groups gavage the normal saline of equivalent, experiment successive administration totally 8 weeks.Administration is got mice right femoral vein blood 40ul after finishing, and puts into the plastic centrifuge tube with cover that fills 0.36ml1% nitric acid and shakes up; Get side 50% femur, digested after weighing, add rare nitric acid and be settled to 5ml, with corresponding liver and the cerebral tissue got of method, with atomic spectrophotometer, carry out blood and bone, liver and brain Determination of Pb; Above-mentioned data statistic analysis adopts the T check.
Table 1 traditional Chinese medicine composition water decocting liquid of the present invention is to plumbous (mg/kg) content influence of Mouse Blood, bone, liver and brain
On the blood lead content impact obviously, each dosage group and model group relatively have significant differences to the traditional Chinese medicine composition water decocting liquid
p<0.01; The traditional Chinese medicine composition water decocting liquid is influential to the bone lead content, and high, middle dosage group and model group relatively have significant differences
p<0.01; On liver, the impact of brain lead content obviously, each dosage group and model group relatively have significant differences to Chinese medicine composition
p<0.01.
Claims (3)
1. a Plumbum removing Chinese medicine composition, is characterized in that being made by following raw material medicaments in part by weight proportioning: Fericarpium Citri Limoniae 5-25 part, Folium fici microcarpae 5-25 part, Ramulus Luffae 10-30 part, Spora Lygodii 5-20 part, Caulis et Folium hedyotis hedyotideae 10-30 part, Pericarpium Citri Reticulatae Viride 5-30 part.
2. Plumbum removing Chinese medicine composition according to claim 1, is characterized in that being made by following raw material medicaments in part by weight proportioning: 9 parts of Fericarpium Citri Limoniaes, 12 parts of Folium fici microcarpaes, 15 parts of Ramulus Luffaes, 9 parts of Spora Lygodii, 12 parts of Caulis et Folium hedyotis hedyotideaes, 9 parts, Pericarpium Citri Reticulatae Viride.
3. the application of the described Chinese medicine composition of claim 1 or 2 in the conventional oral formulations of preparation.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201210459212 CN102935132B (en) | 2012-09-04 | 2012-11-15 | Lead removing traditional Chinese medicine composition |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210322108.3 | 2012-09-04 | ||
| CN201210322108 | 2012-09-04 | ||
| CN 201210459212 CN102935132B (en) | 2012-09-04 | 2012-11-15 | Lead removing traditional Chinese medicine composition |
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| CN102935132A CN102935132A (en) | 2013-02-20 |
| CN102935132B true CN102935132B (en) | 2013-12-18 |
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Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100998742B (en) * | 2006-12-25 | 2010-09-15 | 刘秀萍 | Traditional Chinese medicine decoction for treating lead poisoning |
| KR101405719B1 (en) * | 2007-07-02 | 2014-06-10 | (주)아모레퍼시픽 | Composition for detoxifying heavy metal comprising ginseng fruit extract |
| CN101756233A (en) * | 2008-12-04 | 2010-06-30 | 崔翔 | Medicinal and edible traditional Chinese medicine with function of promoting lead removal |
| CN101548993B (en) * | 2009-05-06 | 2011-09-21 | 辽宁大学 | Application of Japanese climbing fern spore in preparing lead excretion medicines or health products |
| CN102258628B (en) * | 2011-07-19 | 2012-11-07 | 辽宁大学 | Chinese medicinal composition with lead removal promoting effect |
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