CN105147944B - A kind of Chinese medicine composition, its preparation and its preparation method and application - Google Patents
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Abstract
The invention discloses a kind of Chinese medicine compositions, its preparation and its preparation method and application；The Chinese medicine composition, including the following raw material medicine：10~15 parts of purple sesame, 10~15 parts of the root of bidentate achyranthes, 1~3 part of dried orange peel, 10~15 parts of Cortex Eucommiae, 10~15 parts of Poria cocos, 10~15 parts of Chinese yam, 1~3 part of matrimony vine, 1~3 part of Radix Glycyrrhizae；The Chinese medicine preparation more preferably provided through the invention by above-mentioned raw materials medicine is made of the preparation method of wine；Its compatibility of the invention meets Chinese medicine " monarch " principle, and flavour of a drug number is less, has many advantages, such as that curative effect is high, has no toxic side effect, starts at all from cause of disease, suit the remedy to the case, to achieve the effect that prevention；In addition, all medicine energy multipaths of monarch in compatibility, multiple target point, preventing vascular hypertension at many levels；The preparation method of the Chinese traditional medicine composition preparation of the present invention is simple, at low cost, is suitable for taking for a long time, is a kind of Chinese medicine composition for safely and effectively preventing vascular hypertension, has a good application prospect.
Description
Technical field
The present invention relates to the field of Chinese medicines more particularly to a kind of Chinese medicine composition, its preparation and its preparation method and application.
Background technology
Due to modern society's dog-eat-dog, Urban population is generally in high pressure intensive work environment, social inferior health
State crowd is also in rising trend, and inferior health is increasingly becoming the secret worry received and lived with work with life.Wherein hypertension
(Hypertension) be a kind of with arterial pressure raising be the angiocardiopathy mainly showed, either developed country still
Developing country is all a kind of common disease.The treatment of hypertension is based on western medicine at present, and Western medicine can only temporarily improve disease
Shape, side effect is serious, for example diuretics Hydrochioro can cause blood potassium to reduce, uric acid increases；(such as Kato is general for ACEI classes drug
Profit) cough, angioedema may be caused；Calcium antagonist may also can cause headache, oedema, flushed face etc..
Some researches show that the effects to boil water for taking decompression after, purple sesame slice at present, however the target site that purple sesame is directed to has
Limit, and vascular hypertension morbidity be since the negative and positive of liver,kidney,spleen, the normal physiological function of qi and blood are destroyed, and instead gas, fire,
Therefore the pathological state that wind, phlegm, deficiency of Yin sun decline carries out multipath using Chinese medicine composition, multiple target point, treats height at many levels
Blood pressure disease still has room for promotion.
" integration of drinking and medicinal herbs " is one of the contribution to mankind's most worthy among Chinese original medicine；Chinese medicine always emphasizes " medicine
Treat and be not so good as dietotherapy ", dietotherapy becomes the optimal selection that modern pursues healthy diet；People are allowed to be dispelled during enjoying cuisines
Slight illness avoids and has an injection, takes medicine or even pain of surgery.China GB29922-2013《Special medicine purposes formula food general rule》
Wholefood clear stipulaties in national food safety standard：2.1.1 full nutrition formula food：It is full to can be used as single source of nutrition
The special medicine purposes formula food of foot-eye crowd's nutritional need；2.1.2 specific full nutritional formulas：It can be used as single battalion
Foster source meets the special medicine purposes formula food of target group's nutritional need under specified disease or medical condition.
Invention content
In view of this, the present invention by experimental study, provide a kind of Chinese medicine composition, its preparation and preparation method thereof and
Using the Chinese medicine composition has significant curative effect to vascular hypertension, and safe, has no toxic side effect.
In a first aspect, the invention discloses a kind of Chinese medicine composition, including the following raw material medicine：10~15 parts of purple sesame, the root of bidentate achyranthes
10~15 parts, 1~3 part of dried orange peel, 10~15 parts of Cortex Eucommiae, 10~15 parts of Poria cocos, 10~15 parts of Chinese yam, 1~3 part of matrimony vine, Radix Glycyrrhizae 1~
3 parts.
In an embodiment of the present invention, the raw material medicines in portions by weight number is more preferably：
In an embodiment of the present invention, the raw material medicines in portions by weight number is more preferably：
In an embodiment of the present invention, the raw material medicines in portions by weight number is more preferably：
In an embodiment of the present invention, the raw material medicines in portions by weight number is more preferably：
Purple sesame, by evil beneficial spleen, hard bone is good for muscle, and it is China's tradition rare traditional Chinese medicine that happy face, which stays color, " China's spirit that purple sesame is also referred to as
Sesame ", it is sweet in flavor mild-natured, it is salty by evil beneficial spleen.Hard bone is good for muscle, pleases face and stays color, long term usage is lengthened the life.Purple sesame is strengthened the body resistance to consolidate the constitution, and immune function is enhanced,
Improve the great function of Abwehrkraft des Koepers.Bidirectional modulation function of human body balances on the whole, transfers internal body vigor, adjusts people
Body metabolism function improves autoimmunity ability, promotes whole internal organ or organ function normalization.Can be used for the heart, lung,
The dirty valetudinarian, invalid of liver,spleen,kidney.Purple sesame, which is cured the disease, kind is related to breathing, cycle, digestion, nerve, endocrine and each system such as immune；
Cover inside and outside, woman, youngster, each section's disease of face.Improve and improves human quality, by enhancing leukocyte activity and phagocytic function,
Promote lymphopoiesis and conversion, enhances division and the regeneration enhancing human immunity of cell.Contained by improving human dopamine
Amount promotes attention, reagency and the memory of human brain, enhances learning ability.By promoting the synthesis of nucleic acid, protein, change
Kind hematopoiesis function is conducive to the defense mechanism for enhancing human body.By improving the metabolic capability and Regeneration and Repair ability of liver cell, rise
To protecting liver and detoxication effect.Purple sesame the special peptidoglycan contained can effectively remove the ability of human free radical, improve the activity of cell
With metabolic capability, prevent the generation of senile dementia, and makes Skin Cell that tight skin be kept to compact, glossy, function of delaying senility.
Purple sesame alcohol compound, polysaccharide can enhance myocardial contractive power, and softening blood vessel, reducing heart rate have the function that decompression；Simultaneously also
Blood glucose can be reduced, insulin is promoted, diabetes patient is helped to get well, treats hypertension and hyperlipemia.
Root of bidentate achyranthes filling liver kidney is rushed down extravesated blood picric acid and is put down.Foot is fainted cloudy, shaoyin channel medicine (liver kidney), and all medicine downlinks can be drawn.Wine steams then sweet
Acid and warm, liver and kidney benefiting, strengthening the bones and muscles, control control waist and knee ostalgia, sufficient impotence muscle contraction (downlink therefore reason foot, then muscle relaxes tonifying liver, and blood is then stopped bitterly), the moon
Impotence loses drown (muscle declines then impotence, and kidney deficiency, which is then lost, drowns), chronic malaria diarrhea, few gas in wound (with the work(of native all filling liver kidney).
Dried orange peel is warm-natured, acrid flavour, bitter.Enter the spleen channel, stomach, lung channel.Regulating qi-flowing for strengthening spleen, in tune, eliminating dampness, resolving sputum.Cure mainly taste
The abdominal fullness and distention or pain of the stagnation of the circulation of vital energy, indigestion.Abdominal distension uncomfortable in chest, indigestion and loss of appetite loose stool in wet turbid resistance.The cough and asthma of phlegm obstructing lung.
For chest gastral cavity turgor, deficiency of food is vomited and diarrhoea, coughing with a lot of sputum.
Cortex Eucommiae, acrid flavour are flat.Main pain along spinal column, bowl spares strengthening the essence gas, hard muscles and bones, Qiang Zhi, the tough and tensile person of matter, vital essence must be sufficient, therefore
Also can the firm person muscles and bones qi and blood.It is wet except itching under the moon, mend skin dampness removing.Dribbling urination.The gas of the excessive pipe of heavily fortified point.Long term usage is made light of one's life by commiting suicide resistance to
Always.Strong limbs.The skin of Cortex Eucommiae wood, the tough and dense person of wood skin this for most, therefore the skin of people can be mended.Wherein there is silk even to belong to continuous again,
Have muscle as here, therefore again can continuous muscles and bones.Because shape is in the hope of reason, then known to its effect.
Poria cocos, nature and flavor are sweet, light, put down.Thoughts of returning home warp, lung channel, the spleen channel, kidney channel.Sharp water medicine, diuretics with the action of eliminating dampness.With kidney tonifying profit
Water, the effect made light of one's life by commiting suicide are a kind of rare medicinal herbs that ancient times people can take for a long time.It can be used for difficult urination, oedema turgor, phlegm
Drink inverse cough, vomiting, spleen eating less, diarrhea, palpitation and restlessness, insomnia forgetfulness, seminal emission gonorrhoea.
Chinese yam rhizome is sweet in flavor, mild-natured.Returns spleen, lung, kidney channel.Tonifying spleen nourishing the stomach, engender liquid and benefic lung, the puckery essence of kidney tonifying are clearing heat and detoxicating.It cures mainly
Spleen eating less, endless diarrhea, the deficiency syndrome of the lung breath with cough, under emission due to the kidney deficiency, band, frequent micturition, abnormal heat quench one's thirst.
Matrimony vine, Gan Ping and moisten, property nourishing can, nourish the liver to improve visual acuity, nourshing kidney moistening lung, production of sperm QI invigorating, can hard muscles and bones, resistance to cold and heat, gently
Body is not old, adjusts immunity, anti-aging, antitumor, antifatigue, Antiradiation injury, adjusts blood fat, hypoglycemic, blood pressure lowering, protection
Reproductive system improves eyesight, improves respiratory tract disease resistance, beautifying face and moistering lotion, and moisturizing is the top grade in Chinese medicine.
Radix Glycyrrhizae, flat property and sweet taste, return 12 warps.Control vital organs of the human body fever and chills perverse trend, hard muscles and bones, long muscle, times strength, removing toxic substances,
Long term usage is made light of one's life by commiting suicide macrobiosis.It is ripe to go pharyngalgia with exterior cold is dissipated with purging intense heat heat, heat symptoms caused by an exopathgen are removed, healthy tendency, yin-nourishing blood, tonifying spleen and stomach, moistening lung are delayed.It is longer than
It relieves inflammation or internal heat, with clearing heat and detoxicating, the power that moistens the lung and relieve the cough victory.For phlegm-heat cough, abscess of throat etc..
Chinese medicine composition of the present invention is under guidance of traditional Chinese medicine theory, in conjunction with modern pharmacology research achievement, according to invention
People's research practice experience for many years, chooses eight kinds of bulk pharmaceutical chemicals according to made of certain weight prescription.Compatibility of the present invention is reduced the number of sternly
Sincerely, diving, square medication is proper, and preventive and therapeutic effect is fairly obvious, and cure rate is high.
Second aspect, the invention also discloses a kind of preparation method of Chinese medicine composition, being will as described in relation to the first aspect
Bulk pharmaceutical chemicals are made of water extraction and alcohol precipitation method.
As described herein, " water extraction and alcohol precipitation method " is understood by row industry routine and is carried out；Preferably comprise following steps：
Bulk pharmaceutical chemicals are taken, adds 6-10 times to measure water, decocts 1-3 times, it is 1-3 hours each, receive concoction；It stands, leaching supernatant is dense
Contracting, adds 2-3 times to measure alcohol (preferably 95% volumetric concentration), and (preferably precipitates overnight) is precipitated after stirring；Take precipitation, ethanol wash,
Alcohol washing lotion is abandoned, sediment, the i.e. Chinese medicine composition are obtained.
In preparing the application of drug of prevention and treatment vascular hypertension, Chinese medicine composition of the present invention can be by this field
Conventional formulation method is prepared into various clinically conventional formulations, for example, can add into a effective amount of Chinese medicine composition of the present invention
Enter pharmaceutically acceptable auxiliary material (such as disintegrant, lubricant, binder, dispersant etc.), is prepared into various oral preparations, this hair
It is bright to be preferably made pulvis, decoction, tablet, granule, capsule, powder, mixture, pill, oral solution, wine.
It to those skilled in the art, can be according to conventional formulation method, gently in the case where knowing active constituent
Easy is made various formulation products, while the auxiliary material employed in preparation is also well known in the art, such as carboxyrnethyl starch sodium, sugarcane
Icing Sugar, sesame oil etc..
Third aspect present invention provides a kind of Chinese medicine preparation, including Chinese medicine composition described in first aspect pharmaceutically may be used
Receive auxiliary material composition.
Preferably, the effective quantity is：The weight of any Chinese medicine composition as described in relation to the first aspect accounts for Chinese medicine preparation
60~80%.
Preferably, the pharmaceutically acceptable auxiliary material includes diluent and lubricant, and the diluent is selected from such as
Under it is one or more：Starch, lactose, dextrin, microcrystalline cellulose, sucrose；The lubricant is selected from magnesium stearate and/or micro-
Powder silica gel.
Preferably, the Chinese medicine preparation is pulvis, sublimed preparation, decoction, tablet, granule, capsule, powder, mixture, ball
Agent, oral solution, wine.
The present invention also provides the preparation method that a kind of Chinese medicine preparation is wine in fourth aspect, includes the following steps：
The bulk pharmaceutical chemicals are put into the wine that 10000~20000 parts of alcoholic strengths are 50 °~60 °, it is closed to be protected from light immersion 15 days
More than, it stirs 1 time within every 2 days, obtained original is steep in wine；
The original is added in edible gelatin to steep in wine, is filtered after stirring, obtains filtrate；
Egg white is added in the filtrate, suspended matter has been heated to after stirring and has floated on filtrate surface, filtering can be prepared by institute
State Chinese medicine preparation.
Preferably, further include following steps：
Honey sweetener, essence and edible glycerol are added in the filtrate；
The additive amount of the honey sweetener is the 2%~5% of the filtrate weight.
Preferably, further include following steps：
The additive amount of the edible gelatin is that the original steeps in wine 0.5 ‰~the 10 ‰ of weight, and the additive amount of the egg white is
The original steeps in wine 0.5 ‰~the 10 ‰ of weight.
The Chinese medicinal composition preparation mouthfeel level of fourth aspect present invention is abundant, mellow sweetness, and not top after drinking is not easy
It is drunk, and the digestive function and body resistivity of stomach are enhanced, stimulation of the alcohol to stomach is reduced, is a kind of effective health
Road.
Fifth aspect present invention provides one kind, and Chinese medicine composition prevents, treats vascular hypertension in preparation as described in relation to the first aspect
Drug in application.
Beneficial effects of the present invention：Its compatibility meets Chinese medicine " monarch " principle, and flavour of a drug number is less, high with curative effect,
The advantages that having no toxic side effect starts with from cause of disease, suits the remedy to the case, at all to achieve the effect that prevention；In addition, the monarch and his subjects' assistant in compatibility
Enable all medicine multipaths, multiple target point, prevent vascular hypertension at many levels.Therefore, Chinese medicine composition of the invention, which has, prevents
With the double effects for the treatment of vascular hypertension；The preparation method of the Chinese traditional medicine composition preparation of the present invention is simple, at low cost, is suitable for long-term clothes
With, be it is a kind of safely and effectively prevent vascular hypertension Chinese medicine composition, have a good application prospect.
Specific implementation mode
It is that principles and features of the present invention are described below, the given examples are served only to explain the present invention, is not intended to
Limit the scope of the present invention.
The preparation (1) of 1 Chinese medicine composition of embodiment
Each bulk pharmaceutical chemicals (unit is weighed by following weight:g):
The preparation (2) of 2 Chinese medicine composition of embodiment
Each bulk pharmaceutical chemicals (unit is weighed by following weight:g):
The preparation (3) of 3 Chinese medicine composition of embodiment
Each bulk pharmaceutical chemicals (unit is weighed by following weight:g):
The preparation (4) of 4 Chinese medicine composition of embodiment
Each bulk pharmaceutical chemicals (unit is weighed by following weight:g):
The preparation (5) of 5 Chinese medicinal composition preparation of embodiment
Each bulk pharmaceutical chemicals (unit is weighed by following weight:g):
The bulk pharmaceutical chemicals are put into the wine that 10kg alcoholic strengths are 50 °, it is closed to be protected from light immersion 15 days, it stirs 1 time within every 2 days,
Obtained original is steep in wine；The original is added in edible gelatin to steep in wine, is filtered after stirring, filtrate, the additive amount of the edible gelatin are obtained
The 0.5 ‰ of weight of steeping in wine for the original；Add egg white, the additive amount of the egg white is that the original steeps in wine the 0.5 ‰ of weight, is stirred
It has been heated to suspended matter after mixing and has floated on filtrate surface, filtering can be prepared by the Chinese medicine preparation.
The preparation (6) of 6 Chinese medicinal composition preparation of embodiment
Each bulk pharmaceutical chemicals (unit is weighed by following weight:g):
The bulk pharmaceutical chemicals are put into the wine that 15kg alcoholic strengths are 55 °, it is closed to be protected from light immersion 20 days, it stirs 1 time within every 2 days,
Obtained original is steep in wine；The original is added in edible gelatin to steep in wine, is filtered after stirring, filtrate, the additive amount of the edible gelatin are obtained
The 5 ‰ of weight of steeping in wine for the original；Add egg white, the additive amount of the egg white is that the original steeps in wine the 5 ‰ of weight, after stirring
It has been heated to suspended matter and has floated on filtrate surface, filtering can be prepared by the Chinese medicine preparation.
The preparation (7) of 7 Chinese medicinal composition preparation of embodiment
Each bulk pharmaceutical chemicals (unit is weighed by following weight:g):
The bulk pharmaceutical chemicals are put into the wine that 20kg alcoholic strengths are 60 °, it is closed to be protected from light immersion 30 days, it stirs 1 time within every 2 days,
Obtained original is steep in wine；The original is added in edible gelatin to steep in wine, is filtered after stirring, filtrate, the additive amount of the edible gelatin are obtained
The 10 ‰ of weight of steeping in wine for the original；Add egg white, the additive amount of the egg white is that the original steeps in wine the 10 ‰ of weight, stirring
After be heated to suspended matter and float on filtrate surface, filtering can be prepared by the Chinese medicine preparation.
The preparation (8) of 8 Chinese medicinal composition preparation of embodiment
Each bulk pharmaceutical chemicals (unit is weighed by following weight:g):
The bulk pharmaceutical chemicals are put into the wine that 20kg alcoholic strengths are 60 °, it is closed to be protected from light immersion 15 days, it stirs 1 time within every 2 days,
Obtained original is steep in wine；The original is added in edible gelatin to steep in wine, is filtered after stirring, filtrate, the additive amount of the edible gelatin are obtained
The 1 ‰ of weight of steeping in wine for the original；Honey sweetener is added, the additive amount of the honey sweetener is the filtrate weight
2%；Add egg white, the additive amount of the egg white is that the original steeps in wine the 1 ‰ of weight, has been heated to suspended matter after stirring and has floated on
Filtrate surface, filtering can be prepared by the Chinese medicine preparation.
The preparation (9) of 9 Chinese medicinal composition preparation of embodiment
Each bulk pharmaceutical chemicals (unit is weighed by following weight:g):
The bulk pharmaceutical chemicals are put into the wine that 20kg alcoholic strengths are 60 °, it is closed to be protected from light immersion 15 days, it stirs 1 time within every 2 days,
Obtained original is steep in wine；The original is added in edible gelatin to steep in wine, is filtered after stirring, filtrate, the additive amount of the edible gelatin are obtained
The 1 ‰ of weight of steeping in wine for the original；Honey sweetener is added, the additive amount of the honey sweetener is the filtrate weight
3%；Add egg white, the additive amount of the egg white is that the original steeps in wine the 1 ‰ of weight, has been heated to suspended matter after stirring and has floated on
Filtrate surface, filtering can be prepared by the Chinese medicine preparation.
The preparation (10) of 10 Chinese medicinal composition preparation of embodiment
Each bulk pharmaceutical chemicals (unit is weighed by following weight:g):
The bulk pharmaceutical chemicals are put into the wine that 20kg alcoholic strengths are 60 °, it is closed to be protected from light immersion 15 days, it stirs 1 time within every 2 days,
Obtained original is steep in wine；The original is added in edible gelatin to steep in wine, is filtered after stirring, filtrate, the additive amount of the edible gelatin are obtained
The 1 ‰ of weight of steeping in wine for the original；Honey sweetener is added, the additive amount of the honey sweetener is the filtrate weight
5%；Add egg white, the additive amount of the egg white is that the original steeps in wine the 1 ‰ of weight, has been heated to suspended matter after stirring and has floated on
Filtrate surface, filtering can be prepared by the Chinese medicine preparation.
Embodiment 11 prepares the tablet or capsule of Chinese medicine composition of the present invention
Any Chinese medicine compositions of Example 1-5, add 6-10 times to measure water, decoct 1-3 hours, filter out concoction.
Again plus 6-10 times is measured water, is decocted 0.5-2 hours, is filtered out concoction, merge secondary decocting liquid, stands, leaching supernatant, and concentration is let cool,
Add 2-3 times of concentrate to measure 95% alcohol, stirs precipitates overnight.Precipitation is taken, with 0.2-2 times of 95% ethanol wash 3 times, discards alcohol
Washing lotion, sediment are spare through drying；Pharmaceutical aids are added, vacuum drying crushes granulation, and tabletted or filling is encapsulated.
Manufactured capsule, every for 0.5g, (Chinese medicine composition of the invention accounts for 60%-80% parts by weight, and auxiliary material is to form sediment
Powder accounts for the parts by weight of 20%-40%), it is 3-4 times daily each taking 4-10, best results are administered at empty stomach.
Embodiment 12 prepares the granule of Chinese medicine composition of the present invention
Any Chinese medicine compositions of Example 1-5, add 6-10 times to measure water, decoct 1-3 hours, filter out concoction.
Again plus 6-10 times is measured water, is decocted 0.5-2 hours, is filtered out concoction, merge secondary decocting liquid, stands, leaching supernatant, and concentration is let cool,
2-3 times of concentrate is added to measure 95% alcohol, stirring precipitation 24 hours.Taking precipitate is abandoned with 0.2-2 times of 95% ethanol wash 3 times
Go alcohol washing lotion, sediment spare through drying；Add appropriate pharmaceutical aids, pelletize, dry, whole grain obtains particle, dispenses.
Embodiment 13 prepares the mixture of Chinese medicine composition of the present invention, oral solution
Any Chinese medicine compositions of Example 1-5, add 6-10 times to measure water, decoct 1-3 hours, filter out concoction.
Again plus 6-10 times is measured water, is decocted 0.5-2 hours, is filtered out concoction, merge secondary decocting liquid, stands, leaching supernatant, and concentration is let cool,
Add 2-3 times to measure 95% alcohol, is precipitated 24 hours after stirring.Precipitation is taken, with 0.2-2 times of 95% ethanol wash 3 times, alcohol is discarded and washes
Liquid, sediment are spare through drying；Add appropriate pharmaceutical aids, mixture, oral solution is made.
Contrast test is arranged
Setting embodiment 1~13 is corresponding experimental group 1-13, contrast groups 1
Contrast groups 1 are application reference number：One kind that in 200610171363.7 prepared by the 4th section of page 6 of formula and method
Treat the Chinese medicine of hypertension.
The clinical test of the Chinese medicine composition of the present invention
Clinical symptoms crowd：Clinical definite is hypertensive patient, is divided into 15 groups, every group of 30 people.
Further, the Chinese medicine composition for taking 1~4 group of preparation of experimental group is corresponded to respectively for 1~4 group, take each 20ml,
One time a day, one after each meal avoids edible radish, leaf mustard, mung bean etc., and 3 days as one therapeutic course continuously takes 3 course for the treatment of, and advises life, drink
Food, daily life want regular.
Further, 4~10 groups of Chinese medicinal composition preparations for taking the preparation of experimental group 4~10, take each 20ml, daily
3 times, one after each meal avoids edible radish, leaf mustard, mung bean etc., and 3 days as one therapeutic course continuously takes 3 course for the treatment of, and advises life, diet, rises
Want regular in residence.
Further, 11~13 groups of Chinese medicinal composition preparations for taking the preparation of experimental group 11~13, take each 20ml, often
Days 3 times, one after each meal avoids edible radish, leaf mustard, mung bean etc., and 3 days as one therapeutic course continuously takes 3 course for the treatment of, advise life, diet,
Daily life wants regular.
Further, 14 groups of preparations for taking the preparation of contrast groups 1, one dose per day, 15 days as one therapeutic course take 1 course for the treatment of,
Life, diet, daily life is advised to want regular.
Further, it disregards for 15 groups, life, diet, daily life is advised to want regular.
Curative effect determinate standard
With reference to as defined in the Ministry of Public Health《Clinical Researches of New Drugs guideline draft》Middle hypertension criterion of therapeutical effect judgement：
It is effective:Diastole drops >=10mmHg is simultaneously down to normal or declines 20mmHg or more, headache, dizziness, palpitaition, weak
Etc. clinical symptoms disappear or it is substantially reduced；
Effectively:Diastole drops<10mmHg, but be reduced to normal or decline 10~19mmHg, or shrink drops>
30mmHg；
In vain:Above two standards are not reached.
Comparison of therapeutic table：Table 1
| Group | Number of cases | It is effective | Effectively | In vain |
| 1 | 30 | 26 | 4 | 0 |
| 2 | 30 | 26 | 4 | 0 |
| 3 | 30 | 26 | 4 | 0 |
| 4 | 30 | 22 | 8 | 0 |
| 5 | 30 | 26 | 4 | 0 |
| 6 | 30 | 24 | 6 | 0 |
| 7 | 30 | 25 | 5 | 0 |
| 8 | 30 | 24 | 6 | 0 |
| 9 | 30 | 27 | 3 | 0 |
| 10 | 30 | 26 | 4 | 0 |
| 11 | 30 | 26 | 4 | 0 |
| 12 | 30 | 25 | 5 | 0 |
| 13 | 30 | 26 | 4 | 0 |
| 14 | 30 | 2 | 3 | 25 |
| 15 | 30 | 0 | 0 | 30 |
For the advantageous effect further illustrated the present invention, the present invention provides following model cases：
1, male patient：Mr. Wang, 65 years old.Two years ago is without any inducement sense dizziness of having a headache, and the soreness of waist, aversion to cold and cold limbs, tongue is white, night
Frequent micturition.Its clinical definite is vascular hypertension.Start with the embodiments of the present invention 4 prepare Chinese medicine composition, each 20ml, often
It is drunk 3 times, one after each meal, and life, diet, daily life want regular.It takes effect after 1 course for the treatment of (three days as a treatment course), 3 treatments
Symptom is substantially reduced after journey, and hypertension symptom completely disappears after 8 courses for the treatment of.Follow-up is all gone well for 3 years.
2, female patient：Lee, 55 years old, soreness of waist and knee was dysphoria in chestpalms-soles, insomnia, forgetful, palpitaition.Its clinical definite is height
Blood pressure disease.Start the wine prepared with the embodiment of the present invention 8, each 20ml is drunk 3 times daily, and life, diet, daily life there will be rule
Rule.1 course for the treatment of (three days as a treatment course) symptom is mitigated, and is clearly better after 3 courses for the treatment of, kidney-yin deficiency symptom after 10 courses for the treatment of
It completely disappears.
4, mouthfeel is tested and assessed
Sensory evaluation is by 70 age brackets in 30-60 Sui valuation officer to Chinese medicinal composition preparation made from embodiment 4~6
It is evaluated, only 1 people indicates that taste is general, and 69 people indicate that mouthfeel is very good, and mouthfeel level is abundant, and mellow sweetness is drunk
Not top afterwards, is not easy to make drunk, and no feeling for burning stomach, fruity is pleasant, has a distinctive style.
5, other curative effects
In addition, while detecting blood pressure curative effect, it was further observed that this product has warming up spleen and kidney, enhances transporting, tonifying liver benefit
Kidney, strengthen muscles and bones, tranquilize the mind and promote the intelligence, clearing damp it is active, relieve fatigue, improve immunity of organisms, anti-oxidant and other effects；To wandering arthritis foot
Weak, soreness of waist and knee joint, has a dizzy spell, head wind headache, hemiplegia, numb limb, the equal certain curative effect such as cough and asthma.
In conclusion using a kind of Chinese medicine composition provided by the present invention, its preparation and its preparation method and application,
Compatibility meets Chinese medicine " monarch " principle, and flavour of a drug number is less, has many advantages, such as that curative effect is high, has no toxic side effect, basic from cause of disease
Start with, suit the remedy to the case, to achieve the effect that prevention；In addition, all medicine energy multipaths of monarch in compatibility, multiple target point, multilayer
Vascular hypertension is prevented secondaryly.Therefore, Chinese medicine composition of the invention has the double effects of prevention and treatment vascular hypertension；This
The preparation method of the Chinese traditional medicine composition preparation of invention is simple, at low cost, is suitable for taking for a long time, is that one kind safely and effectively preventing high blood
The Chinese medicine composition for pressing disease, has a good application prospect.
The foregoing is merely illustrative of the preferred embodiments of the present invention, is not intended to limit the invention, all essences in the present invention
With within principle, any modification, equivalent substitution, improvement and etc. done should be included within the scope of protection of the invention god.
Claims (11)
1. a kind of Chinese medicine composition preventing, treating vascular hypertension, which is characterized in that be made of the bulk pharmaceutical chemicals of following parts by weight：
10 ~ 15 parts of purple sesame, 10 ~ 15 parts of the root of bidentate achyranthes, 1 ~ 3 part of dried orange peel, 10 ~ 15 parts of Cortex Eucommiae, 10 ~ 15 parts of Poria cocos, 10 ~ 15 parts of Chinese yam, matrimony vine 1 ~ 3
Part, 1 ~ 3 part of Radix Glycyrrhizae.
2. Chinese medicine composition as described in claim 1, which is characterized in that the parts by weight of the bulk pharmaceutical chemicals are：
10 parts of purple sesame, 10 parts of the root of bidentate achyranthes, 1 part of dried orange peel, 10 parts of Cortex Eucommiae
10 portions of Poria cocos, 10 portions of Chinese yam, 1 portion of matrimony vine, 1 part of Radix Glycyrrhizae；
Or
13 parts of purple sesame, 13 parts of the root of bidentate achyranthes, 2 parts of dried orange peel, 13 parts of Cortex Eucommiae
13 portions of Poria cocos, 13 portions of Chinese yam, 2 portions of matrimony vine, 2 parts of Radix Glycyrrhizae；
Or
15 parts of purple sesame, 15 parts of the root of bidentate achyranthes, 3 parts of dried orange peel, 15 parts of Cortex Eucommiae
15 portions of Poria cocos, 15 portions of Chinese yam, 3 portions of matrimony vine, 3 parts of Radix Glycyrrhizae.
3. a kind of Chinese medicine composition preventing, treating vascular hypertension, which is characterized in that be made of the bulk pharmaceutical chemicals of following parts by weight：
100 parts of purple sesame, 100 parts of the root of bidentate achyranthes, 20 parts of dried orange peel, 100 parts of Cortex Eucommiae, 100 parts of Poria cocos, 100 parts of Chinese yam, 20 parts of matrimony vine, 10 parts of Radix Glycyrrhizae.
4. the preparation method of Chinese medicine composition as claimed in any one of claims 1-3, which is characterized in that by the raw material
Medicine is made of water extraction and alcohol precipitation method.
5. a kind of Chinese medicine preparation, which is characterized in that by any one of the claim 1-3 Chinese medicine compositions and can pharmaceutically connect
It is formed by auxiliary material.
6. Chinese medicine preparation as claimed in claim 5, which is characterized in that the Chinese medicine preparation is sublimed preparation, tablet, granule, glue
It is one or more in wafer, powder, pill, oral solution.
7. Chinese medicine preparation as claimed in claim 5, which is characterized in that the Chinese medicine preparation is vina.
8. the preparation method of Chinese medicine preparation as claimed in claim 5, which is characterized in that include the following steps：
1）The bulk pharmaceutical chemicals, which are put into 10000 ~ 20000 parts of alcoholic strengths, is in 50 ° ~ 60 ° of wine, it is closed be protected from light immersion 15 days with
On, it stirs 1 time within every 2 days, obtained original is steep in wine；
2）The original is added in edible gelatin to steep in wine, is filtered after stirring, obtains filtrate；
3）Egg white is added in the filtrate, suspended matter has been heated to after stirring and has floated on filtrate surface, filtering can be prepared by described
Chinese medicine preparation.
9. the preparation method of Chinese medicine preparation as claimed in claim 8, which is characterized in that in step 3）In：
Honey sweetener is additionally added in the filtrate；
The additive amount of the honey sweetener is the 2% ~ 5% of the filtrate weight.
10. the preparation method of Chinese medicine preparation as claimed in claim 8 or 9, which is characterized in that in step 2）In：It is described edible
The additive amount of gelatin is that the original steeps in wine 0.5 ‰ ~ the 10 ‰ of weight；In step 3）In：The additive amount of the egg white is the original
The 0.5 ‰ of weight of steeping in wine ~ 10 ‰.
11. Chinese medicine composition is preparing answering in preventing, treating the drug of vascular hypertension as described in any one of claim 1-3
With.
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| CN102274346A (en) * | 2010-06-11 | 2011-12-14 | 成都中医药大学 | Medicament or health food composition for preventing hypertension and preparation method and purpose thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102274346A (en) * | 2010-06-11 | 2011-12-14 | 成都中医药大学 | Medicament or health food composition for preventing hypertension and preparation method and purpose thereof |
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