CN103479895A - Heart comforting and brain clearing traditional Chinese medicine composition - Google Patents
Heart comforting and brain clearing traditional Chinese medicine composition Download PDFInfo
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- CN103479895A CN103479895A CN201310413221.7A CN201310413221A CN103479895A CN 103479895 A CN103479895 A CN 103479895A CN 201310413221 A CN201310413221 A CN 201310413221A CN 103479895 A CN103479895 A CN 103479895A
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Abstract
The invention discloses a hear comforting and brain clearing traditional Chinese medicine composition. The purpose is to provide a Chinese medicine preparation which can improve the capacity of the cardiac muscles, has a cardiotonic effect, accelerate blood circulation, restrain thrombosis, regulate blood lipids, blood sugar and blood pressure, boost immunity, strengthen the spleen and nourish the stomach. The Chinese medicine preparation for treating the hypertensive disease comprises, by weight, the following raw materials: 6-10 pars of pseudo-ginseng, 15-30 parts of roots of red-rooted salvia, 10-15 parts of astragali radixes, 5-10 parts of gastrodia elata, 10-15 parts of chrysanthemum, 5-10 parts of ligusticum wallichii and 10-15 parts of seeds of wild jujubes.
Description
Technical field
The present invention relates to a kind of field of Chinese medicines, be specifically related to a kind of myocardium ability that improves, cardiotonic is arranged, accelerate blood circulation, suppress thrombosis, regulate blood fat, blood glucose, blood pressure, the Chinese medicine composition of enhancing immunity, strengthening the spleen and nourishing the stomach.
Background technology
Quickening along with modern life rhythm, improving constantly of quality of life, the diseases such as hyperlipidemia, hyperglycemia, hypertension, arteriosclerosis, insomnia more and more become a lot of people's of puzzlement health problem, and the crowd who suffers from above-mentioned disease also increases gradually, and be the trend risen year by year, and patient age presents the trend of rejuvenation.
Lipid metabolism or running make one or more lipids of blood plasma higher than normally being called hyperlipidemia extremely.Hyperlipidemia is a kind of systemic disease, refers to that blood cholesterol (TC) and/or triglyceride (TG) are too high or HDL-C (HDL-C) is too low, and modern medicine is referred to as dyslipidemia.Lipid is insoluble or be slightly soluble in water, must with the lipoprotein form, exist with protein bound, and therefore, hyperlipidemia is generally hyperlipoproteinemia, and serum lipoprotein concentration raises.Generally acknowledge at present hyperlipidemia, comprised all high compound hyperlipidemias of hypercholesterolemia, hypertriglyceridemia and the two.This disease to the infringement of health be concealment, gradually, carrying out property and general.Its direct infringement is to accelerate systemic atherosclerosis, because the vitals of whole body all will rely on tremulous pulse blood supply, oxygen supply, once tremulous pulse is stopped up by atheromatous plaque, will cause serious consequence.The renal failure that arteriosclerosis causes etc., all closely related with hyperlipidemia.Research datas show in a large number, and hyperlipidemia is apoplexy, coronary heart disease, myocardial infarction, cardiac sudden death is independent and important risk factor.The concentration of the lipid compositions such as hyperlipidemia plasma cholesterol, triglyceride, total fat surpasses arm's length standard.The main harm of hyperlipidemia is to cause atherosclerosis, and then causes numerous relevant diseases, and wherein modal a kind of mortality disease is exactly coronary heart disease.Serious chylomicronemia can cause acute pancreatitis, is another kind of mortality disease.In addition, hyperlipidemia is also an important risk factor that promotes hypertension, impaired glucose tolerance, diabetes.Hyperlipidemia also can cause fatty liver, liver cirrhosis, cholelithiasis, pancreatitis, retinal hemorrhage, blind, peripheral vascular disease.So must pay much attention to the harm of hyperlipidemia, positive prevention and treatment.Hyperlipidemia is the Major Risk Factors that causes mankind's atherosclerosis.As common atherosclerosis, have: coronary heart disease (comprising myocardial infarction, angina pectoris and sudden death), cerebral infarction and peripheral vessels thrombotic disease.The sickness rate of these cardiac and cerebral vascular diseases is high, and harm is large, and disease progression is dangerous, and its mortality rate accounts for the half left and right of mankind's general mortality rate.Treat in the market hyperlipidemia, hyperglycemia, hypertension, arteriosclerosis and mainly contain Statins, the special class of shellfish, natural drug class, and some regulate the health promoting product of blood fat functions.It is comparatively single that the effect of these products becomes, and also do not have a kind of medicine can treat above-mentioned various diseases.
The applicant is from traditional theory of Chinese medical science, by by Radix Notoginseng, Radix Salviae Miltiorrhizae, the Radix Astragali, Rhizoma Gastrodiae, Flos Chrysanthemi, Rhizoma Chuanxiong, the Semen Ziziphi Spinosae a few herbs are passed through compatibility, obtain a kind of myocardium ability that improves, cardiotonic is arranged, accelerate blood circulation, suppress thrombosis, regulate blood fat, blood glucose, blood pressure, enhancing immunity, the strengthening the spleen and nourishing the stomach Chinese medicine composition, it is mainly by improving spleen, stomach, the function of kidney device, strengthen the ability of taste transportation and transformation of water and food, and by improving the function of kidney, and then raising immunity, improve the various functions of health from source, thereby reach the purpose for the treatment of disease.
Summary of the invention
The object of the invention is to: a kind of myocardium ability that improves is provided, cardiotonic is arranged, accelerate blood circulation, suppress thrombosis, regulate blood fat, blood glucose, blood pressure, the Chinese medicine preparation of enhancing immunity, strengthening the spleen and nourishing the stomach.A kind of Chinese medicine preparation of Hypertension, its raw material packet contains the crude drug of following weight portion: Radix Notoginseng 6-10 part, Radix Salviae Miltiorrhizae 15-30 part, Radix Astragali 10-15 part, Rhizoma Gastrodiae 5-10 part, Flos Chrysanthemi 10-15 part, Rhizoma Chuanxiong 5-10 part, Semen Ziziphi Spinosae 10-15 part.
Described crude drug preferably comprises the Chinese crude drug of following weight portion: Radix Notoginseng 8-10 part, Radix Salviae Miltiorrhizae 15-20 part, Radix Astragali 12-15 part, Rhizoma Gastrodiae 6-10 part, Flos Chrysanthemi 12-15 part, Rhizoma Chuanxiong 5-8 part, Semen Ziziphi Spinosae 12-15 part.
More preferably 6 parts of Radix Notoginseng, 15 parts of Radix Salviae Miltiorrhizaes, 10 parts of the Radixs Astragali, 5 parts, Rhizoma Gastrodiae, 10 parts of Flos Chrysanthemis, 5 parts of Rhizoma Chuanxiongs, 10 parts of Semen Ziziphi Spinosaes;
Perhaps
7 parts of Radix Notoginseng, 18 parts of Radix Salviae Miltiorrhizaes, 12 parts of the Radixs Astragali, 8 parts, Rhizoma Gastrodiae, 13 parts of Flos Chrysanthemis, 7 parts of Rhizoma Chuanxiongs, 11 parts of Semen Ziziphi Spinosaes; Perhaps
10 parts of Radix Notoginseng, 30 parts of Radix Salviae Miltiorrhizaes, 15 parts of the Radixs Astragali, 10 parts, Rhizoma Gastrodiae, 15 parts of Flos Chrysanthemis, 10 parts of Rhizoma Chuanxiongs, 15 parts of Semen Ziziphi Spinosaes;
Perhaps
8 parts of Radix Notoginseng, 20 parts of Radix Salviae Miltiorrhizaes, 12 parts of the Radixs Astragali, 8 parts, Rhizoma Gastrodiae, 12 parts of Flos Chrysanthemis, 8 parts of Rhizoma Chuanxiongs, 12 parts of Semen Ziziphi Spinosaes.
It can adopt Chinese medicine composition provided by the present invention conventional pulverizing or prepare pharmaceutically acceptable any dosage forms such as pharmaceutically acceptable tablet, capsule, microsphere, micropill through conventional extraction separation method.
It can adopt following method preparation: the Radix Notoginseng, Radix Salviae Miltiorrhizae, the Radix Astragali, Rhizoma Gastrodiae, Flos Chrysanthemi, Rhizoma Chuanxiong, the Semen Ziziphi Spinosae that take recipe quantity, the above-mentioned raw materials medicine is cleaned to post-drying, after pulverizing respectively with Universalpulverizer under aseptic, dustless condition, decoct with water 3 times, the water that adds respectively 8 times, 6 times, 4 times amounts, decocting time is respectively 3 hours, 2 hours, 2 hours, and merging filtrate concentrating under reduced pressure, drying obtain extract powder, add conventional adjuvant, make pharmaceutically acceptable various dosage form.
In preparation process, can optionally add pharmaceutically acceptable adjuvant.
Chinese medicine preparation of the present invention can also add any have treatment blood fat, blood glucose, blood pressure, and the medicine Chinese medicine of enhancing immunity, strengthening the spleen and nourishing the stomach effect or Western medicine are prepared into pharmaceutically acceptable any dosage form.
Instructions of taking of the present invention: everyone 3 times on the 1st, each 4-6g, 2 months be a course for the treatment of, on average takes onset in 10-15 days.
The specific embodiment
Embodiment 1
Take Radix Notoginseng 60g, Radix Salviae Miltiorrhizae 150g, Radix Astragali 100g, Rhizoma Gastrodiae 50g, Flos Chrysanthemi 100g, Rhizoma Chuanxiong 50g, Semen Ziziphi Spinosae 100g, the above-mentioned raw materials medicine is cleaned to post-drying, after pulverizing respectively with Universalpulverizer under aseptic, dustless condition, cross 100 mesh sieves, obtain medicated powder, above-mentioned various medicated powder is uniformly mixed through mixer, with every bag 5 gram packing, makes Chinese powder medicine of the present invention.
Embodiment 2
Take Radix Notoginseng 70g, Radix Salviae Miltiorrhizae 180g, Radix Astragali 120g, Rhizoma Gastrodiae 80g, Flos Chrysanthemi 130g, Rhizoma Chuanxiong 70g, Semen Ziziphi Spinosae 110g, the above-mentioned raw materials medicine is cleaned to post-drying, after pulverizing respectively with Universalpulverizer under aseptic, dustless condition, cross 120 mesh sieves, obtain medicated powder, above-mentioned various medicated powder is uniformly mixed through mixer, by general method for making, makes Chinese medicine pill of the present invention.
Embodiment 3
Take Radix Notoginseng 100g, Radix Salviae Miltiorrhizae 300g, Radix Astragali 150g, Rhizoma Gastrodiae 100g, Flos Chrysanthemi 150g, Rhizoma Chuanxiong 100g, Semen Ziziphi Spinosae 150g, the above-mentioned raw materials medicine is cleaned to post-drying, after pulverizing respectively with Universalpulverizer under aseptic, dustless condition, cross 120 mesh sieves, obtain medicated powder, above-mentioned various medicated powder is uniformly mixed through mixer, add conventional adjuvant, direct compression, make the tablet of Chinese medicine of the present invention.
Embodiment 4
Take Radix Notoginseng 80g, Radix Salviae Miltiorrhizae 200g, Radix Astragali 120g, Rhizoma Gastrodiae 80g, Flos Chrysanthemi 120g, Rhizoma Chuanxiong 80g, Semen Ziziphi Spinosae 120g, the above-mentioned raw materials medicine is cleaned to post-drying, after pulverizing respectively with Universalpulverizer under aseptic, dustless condition, cross 120 mesh sieves, obtain medicated powder, above-mentioned various medicated powder is uniformly mixed through mixer, and the medicated powder of the mix homogeneously capsule of packing into No. 3, make the capsule of Chinese medicine of the present invention.
Embodiment 5
Take Radix Notoginseng 80g, Radix Salviae Miltiorrhizae 200g, Radix Astragali 120g, Rhizoma Gastrodiae 80g, Flos Chrysanthemi 120g, Rhizoma Chuanxiong 80g, Semen Ziziphi Spinosae 120g, the above-mentioned raw materials medicine is cleaned to post-drying, after pulverizing respectively with Universalpulverizer under aseptic, dustless condition, decoct with water 3 times, the water that adds respectively 8 times, 6 times, 4 times amounts, decocting time is respectively 3 hours, 2 hours, 2 hours, and merging filtrate concentrating under reduced pressure, drying obtain extract powder, add conventional adjuvant, make the granule of Chinese medicine of the present invention.
Experimental example 1
Diagnostic criteria: person's Evaluation of Diagnostic Criteria of Hypertension and the classification more than 18 years old within 1999, in World Health Organization (WHO)/international hypertension alliance (WHO-ISH) Treatment Guidelines for Hypertension, worked out, see the following form 1.
The definition of table 1. blood pressure level and classification (mmHg)
| Classification | Systolic pressure | Diastolic pressure |
| Ideal bp | ＜120 | ＜80 |
| Normal arterial pressure | ＜130 | ＜85 |
| Normal high value | 130～139 | 85～89 |
| 1 grade of hypertension (slightly) | 140～159 | 90～99 |
| Subgroup: borderline hypertension | 140～149 | 90～94 |
| 2 grades of hypertension (moderate) | 160～179 | 100～109 |
| 3 grades of hypertension (severe) | ≥180 | ≥110 |
| Isolated systolic hypertension | ≥140 | ＜90 |
| Subgroup: borderline hypertension | 140～90 | ＜90 |
Observational technique:
Make a definite diagnosis 300 routine patients with hypertension according to above diagnostic criteria, its mild or moderate 168 examples, moderate 88 examples, severe 44 examples.According to the difference of blood pressure classification, allow the patient take the Chinese medicine 2 months of the embodiment of the present invention 5 preparation according to above-mentioned instructions of taking.
Curative effect determinate standard:
Produce effects: 1. more than diastolic pressure decline 10mmHg, and reach normal range; Though 2. diastolic pressure be not down to normally descended 20mmHg or more than;
Effectively: 1. diastolic pressure descends not as good as 10mmHg, but has reached normal range; 2. diastolic pressure is treated front decline 10-19mmHg, but does not reach normal range; 3. more than systolic pressure is treated front decline 30mmHg; Must possess wherein 1.
Invalid: as not reach above standard.
The therapeutic effect statistics:
Obvious effective rate 85%
Effective percentage 10%
Inefficiency 5%
Experimental example 2
2.1 case is selected
Observe the routine insufficiency of kidney-YANG patient of case 300: test group 200 examples, matched group 100 examples.
2.2 Therapeutic Method
Reinforcing the kidney and supporting YANG, QI invigorating is filled up, bone and muscle strengthening.
2.3 treatment group is selected medicine: the medicine that oral embodiment 1 makes, every day 3 times, each 10 milliliters, the lighter 15 days is a course for the treatment of, severe one can extend 30 days.
2.4 matched group is selected medicine: NANBAO every day 3 times, each 6,30 days courses for the treatment of.
2.5 curative effect determinate standard
By healing, produce effects, effective, invalid level Four, evaluate:
A cures: clinical symptom disappearance, it is normal that nosetiology etc. inspection is recovered.
The B produce effects: clinical symptoms is clearly better.
C is effective: after medication, the state of an illness takes a turn for the better to some extent or partly sb.'s illness took a favorable turn.
D is invalid: after medication one the course for the treatment of state of an illness without obviously progressive or increase the weight of to some extent.
2.6 result
The routine patient of test group 200, treat the 1-3 course for the treatment of, and total effective rate reaches 99%, cures obvious effective rate 9l%, effective 8%, invalid 1%.
The routine patient of matched group 100, treat the 1-3 course for the treatment of, and total effective rate 71%, cure obvious effective rate 57%, effective 14%, invalid 29%.
Curative effect compares: as shown in table 2, treatment group total effective rate and cure rate, apparently higher than matched group, are learned and are processed by statistics, and difference all has very significant (P<0.01).
Table 2 liang group curative effect relatively
| Group | Cure example (%) | Produce effects example (%) | Effectively routine (%) | Invalid example (%) |
| Treatment group | 100(50) | 80(40) | 18(9) | 2(1) |
| Matched group | 25(25) | 32(32) | 12(12) | 31(31) |
Experimental example 3 adopts the intestinal advance rate experiment of mice charcoal end, and research strengthening the spleen and nourishing the stomach sheet improves the effect of intestinal function.
Adopt mice as animal subject, get 50 mices, male and female half and half, body weight is 18-22g, is divided at random 6 groups: high dose group, middle dosage group, low dose group, positive controls, model group, 10 every group.Model group is according to the dosage gavage normal saline of 0.2ml/10g; Positive controls gavage 2.0g/k Yangwei Tablets; High, normal, basic dosage group gives respectively strengthening the spleen and nourishing the stomach sheet 4.0g/kg, 2.0g/kg, 1.0g/kg gavage, successive administration 15 days.The last administration, after mice fasting 24h, with containing 10% charcoal end suspension oral gavage, volume is 20ml/kg, and after 10min, de-disconnected cervical vertebra is put to death, and opens abdominal cavity and separates mesentery, the clip upper end is from pylorus, and Length of intestine, to the intestinal tube of ileocecus, is surveyed as " small intestinal total length " in lower end; Distance from pylorus to the prepared Chinese ink forward position is as " prepared Chinese ink is at the enteral advance distance ".Calculate prepared Chinese ink propelling rate by following formula.Prepared Chinese ink propelling rate (%)=prepared Chinese ink is in enteral advance distance (cm)/small intestinal total length (cm) * 100%.The medicine that wherein high dose group, middle dosage group, low dose group are used prepares according to embodiment 2.
Result: as table 3.Compare the prepared Chinese ink propelling rate (P<0.05) of the basic, normal, high dosage energy of strengthening the spleen and nourishing the stomach sheet significance rising mice enteral with the model group mice.
The impact (means ± s) of table 3 strengthening the spleen and nourishing the stomach sheet on mice prepared Chinese ink propelling rate
* p<0.05, * * p<0.01 is compared with model group
Conclusion: the prepared Chinese ink propelling rate of strengthening the spleen and nourishing the stomach sheet significance rising mice enteral has the effect that promotes that intestinal advances.
Experimental example 4: adopt the gastric emptying experiment, research strengthening the spleen and nourishing the stomach sheet improves the effect of stomach function.
Adopt mice as animal subject, get 50 mices, male and female half and half, body weight is 18-22g, is divided at random 5 groups: high dose group, middle dosage group, low dose group, positive controls, model group, 10 every group.Model group is according to the dosage gavage normal saline of 0.2ml/10g; Positive controls gavage 2.0g/kg Yangwei Tablets; High, normal, basic dosage group gives respectively strengthening the spleen and nourishing the stomach sheet 4.0g/kg, 2.0g/kg, 1.0g/kg gavage, successive administration 15 days.Before carrying out the gastric emptying experiment, mice fasting 24h.After the last administration after 30min, 0.1% methyl orange solution gavage 0.2ml, after 20min, each group mice is put to death, ligation cardia and pylorus, from the disconnected stomach of getting, stomach is placed in small beaker, add in the 10ml distilled water, cut off gastral cavity, gastric content is fully washed in distilled water, with NaHCO3 solution adjust pH, pour graduated centrifuge tube into to 6.0-6.5, with the centrifugal 10min of 2000rpm, get 752 type spectrophotometer (420nm) colorimetrics for supernatant, with the distilled water zeroing, the optical density recorded is methyl orange optical density in stomach.And, after adding the 10ml distilled water to shake up with 0.1% methyl orange 0.2ml, record its optical density as radix methyl orange optical density, and calculate the methyl orange Stomach residue rate by following formula, reflection gastric emptying speed.Methyl orange Stomach residue rate (%)=stomach methyl orange optical density/radix methyl orange optical density * 100%.The medicine that wherein high dose group, middle dosage group, low dose group are used prepares according to embodiment 3.
Result: as table 4.With the model group mice, compare, the basic, normal, high dosage energy of strengthening the spleen and nourishing the stomach sheet significance reduces the methyl orange residual rate (P<0.05) of gastric.
The impact (means ± s) of table 4 strengthening the spleen and nourishing the stomach sheet on gastric emptying
* p<0.05, * * p<0.01 is compared with model group
Conclusion: strengthening the spleen and nourishing the stomach sheet energy significance reduces the methyl orange residual rate of gastric, has the effect that promotes gastric emptying.
Experimental example 5
Accept patient's 100 examples for medical treatment, the patient suffers from hyperlipidemia, hypertension, what have also suffers from hyperglycemia, and 60.5 years old patient's mean age, maximum patient is 78 years old, minimum patient is 36 years old, the male patient has 60 examples, and female patient 40 examples are taken the medicine arrived of the embodiment of the present invention 4, every day three times, take continuously 2 months.Select medical history, the state of an illness, age, sex simultaneously and suitable with routine treatment suffer from hyperlipidemia, hyperpietic's 50 examples as a control group, 61 years old patient's mean age, maximum patient is 77 years old, minimum patient is 42 years old, the male patient has 30 examples, female patient 20 examples, carry out paired observation according to conventional Therapeutic Method.
Clinical criteria:
Hyperlipidemia: in serum, T-CHOL surpasses 5.75mmol/L, and triglyceride surpasses 1.80mmol/L.
Hypertension: systolic pressure meets or exceeds 170mmHg and diastolic pressure meets or exceeds 95mmHg.
Efficacy assessment standard:
Hyperlipidemia: recovery from illness, clinical symptoms, sign disappear or basic the disappearance, and the syndrome integration reduces >=95%; Produce effects, clinical symptoms, sign are obviously improved, and the syndrome integration reduces >=70%; Effectively, clinical symptoms, sign all take a favorable turn. and the syndrome integration reduces >=30%; Invalid, clinical symptoms, sign are not improved, even increase the weight of, the syndrome integration reduces less than 30%.
Hypertension: recovery from illness, controlling of blood pressure is below horizontal at 140/90mmHg, without obvious clinical symptoms; Produce effects, controlling of blood pressure is below horizontal at 140/90mmHg, and obviously clinical symptoms is most of disappears; Effectively, controlling of blood pressure is below horizontal at 140/90mmHg, and obviously clinical symptoms partly disappears; Invalid, blood pressure does not reach above-mentioned level, and clinical symptoms is obvious.
Efficacy result: treatment group and matched group curative effect are relatively in Table 5.
Table 5
Experimental example 6
Clinical data
The present invention suffers to 100 examples the patient who has a delicate constitution in various degree and has carried out clinical experimental study, inclusion criteria: (1) age: 18-60 year.(2) have the Symptoms had a delicate constitution, the patient's that has a delicate constitution symptom comprises short wind, easily tired, has a dizzy spell, not in the mood to talk, sit and also very easily perspire, be afraid of very much blowing, be apt to catch cold, One's face was like wax, there is no color, and eyelid, fingernail are pale, have a dizzy spell, blurred vision, eyes are dry and astringent, hair is withered, xerosis cutis, nervous, rapid heart beat, sleep poor, forgetful, the symptom such as often feel pins and needles in one's hands and feet; The women also shows as hypomenorrhea, and color is light, amenorrhea etc.; (3) vital sign is steady.
Therapeutic Method
Selected patient's 100 examples, give powder of Chinese traditional medicine prepared by the embodiment of the present invention 1.
Usage: oral, everyone 3 times on the 1st, each 6g, 2 months be a course for the treatment of
Therapeutic outcome
Before treatment, 100 patients' symptom is carried out to itemized record, after treating 2 months, this 100 routine patient's doing well,improving situation is added up.Statistical result is as shown in table 6.
Criterion of therapeutical effect:
Cure: patient's symptom disappears fully, and health status is greatly improved;
Produce effects: patient's symptom obviously alleviates, and health status is greatly improved;
Effectively: patient's symptom alleviates to some extent, but still is attended by slight having a delicate constitution;
Invalid: symptom is unchanged.
Table 6 is taken the curative effect statistics of medicine after three months
| ? | Cure | Produce effects | Effectively | Invalid | Total number of cases | Effective percentage |
| Statistical magnitude | 28 examples | 54 examples | 18 examples | 0 example | 100 | 100％ |
During administration, the patient all has no adverse reaction.
Experimental example 7 acute toxicities
40 of Kunming kind white mice, male female half and half, body weight 18-22 gram.Give embodiment 1 through gavage and make powder 50ml/kg/ time, within every eight hours, be administered once, every Mus is administered three times altogether.Continuous Observation 7 days.
After administration, none example death in 7 days, ingest, take the photograph the no abnormality seens such as water, spontaneous activity.The LD50 that embodiment 1 makes powder should be greater than 50ml/kg.
Application Example
Case 1
The male, 48 years old, 20 years hypertension histories, obstinate,, headache, dizziness, insomnia high with hyperlipidemia, fatty liver, serum creatinine level, the symptom such as weak, diet is depressed.Take the capsule 6 months of the embodiment of the present invention 1 preparation, above-mentioned symptom disappears, and it is normal that every clinical indices is recovered.
Case 2
The male, 50 years old, suffer from hypertension, with hyperlipemia, headache, dizziness, insomnia forgetfulness, cardiac blood supply deficiency.Within 2009, accept Drug therapy of the present invention, take the nearly half a year of capsule of the embodiment of the present invention 2 preparations, above-mentioned symptom disappears substantially, and it is normal that every clinical indices is recovered.
Case 3
The women, 61 years old, start to suffer from hypertension in 1998, with hyperlipemia and heart disease.Accepting the front blood pressure level of Drug therapy of the present invention is that 180/100mmHg is upper and lower.Within 2007, work the capsule after 1 year of taking the embodiment of the present invention 3 preparation, above-mentioned symptom disappears, and the clinical examination indices approaches normal.
Case 4
The women, 65 years old, accept before Drug therapy of the present invention blood pressure level upper and lower at 175/105mmHg, and with headache, dizziness, tinnitus, cardiopalmus, breathe hard, the symptoms such as edema of lower limbs, numb hand and foot.Take the capsule of the embodiment of the present invention 4 preparation after two courses for the treatment of, above-mentioned symptom significantly goes down.After the treatment of two courses for the treatment of, health indices result of clinical detection all recovers normal again.The state of an illness did not appear repeatedly in 2 years after paying a return visit the confirmation withdrawal.
Case 5
The women, 52 years old, suffer from hypertension and within 5 years, have a surplus, blood pressure maintains 170/120mmHg often, often dizzy headache, irascible temperament, irritability, insomnia and dreamful sleep, numb limbs and tense tendons, five is vexed hot-tempered, red tongue, thin fur, stringy and thready pulse, once took various depressor, and effect is undesirable, take two courses for the treatment of of tablet that embodiment 3 obtains, symptom is clearly better, and blood pressure is down to 150/95mmHg.The patient continues again to take a course for the treatment of, by return visit, and blood pressure stabilization, the mental status is good, the phenomenon of hypertension 2 years, do not occur so far more.
Case 6
The women, 63 years old, suffer from hypertension, hyperlipidemia 8 years, dizzy serious, complexion is floating red, upper palpebra inferior duskiness, headache and dizziness, insomnia, the build obesity, blood pressure 180/120mmHg, blood fat, T-CHOL are 8.6mmol/L.With 4 one courses for the treatment of of Chinese medicine embodiment of the present invention, all diseases obviously alleviate, after adhere to taking three courses for the treatment of, blood pressure is down to 120/85mmHg, T-CHOL is down to 4.6mmol/L, can normally go to work, and follows up a case by regular visits in 3 years health good, blood pressure, blood fat do not raise.
Case 7
The male, 71 years old, dizzy three months of main suit, irritability, insomnia, sensation of oppression over the chest with shortness of breath, blood pressure 185/110mmHg when medical, laboratory examination cholesterol 320mg%, beta Lipoprotein 1578mg%, triglyceride 96mg%, be diagnosed as hypertension, hyperlipidemia, takes the Chinese medicine effect always not good.Take embodiment of the present invention blood pressure 120/80mmHg after 5 one months, cholesterol is down to 275mg%, and beta Lipoprotein is down to 450mg%, triglyceride 70mg%, and the dizzy and transference cure uncomfortable in chest of patient, can normally go to work, and appears body in order.
Case 8
The women, 28 years old, often overtime work, the sensation short wind, easily tired, sometimes have a dizzy spell.Take the embodiment of the present invention after 4,2 months, symptom be improved significantly, in high spirits, have rosy cheeks, speak and also strength arranged, rocky symptom disappears fully.
Case 9
The women, 32 years old, like cold perspiration, and with soreness of the waist and knees, cold and pain in the lower abdomen, shortness of breath and palpitation, the symptoms such as limbs fatigue.Take the embodiment of the present invention 3 medicines, after 2 months, symptom be improved significantly, the eumenorrhea, have rosy cheeks, the psychroalgia of lower abdomen disappears fully.
Case 10
The female, 51 years old, easy catching a cold, often occurred that eyes are dry and astringent, nervous, rapid heart beat, sleep poor, forgetful, the symptoms such as numbness of hands and feet.Take the embodiment of the present invention 2 and treated, after 2 months, symptom be improved significantly, the number of times that is mainly manifested in flu is obviously few, the situation that eyes are dry and astringent also is clearly better.The situation of nervous cardiopalmus be improved significantly, sleep quality might as well, the numbness of hands and feet transference cure.
Claims (9)
1. the Chinese medicine preparation of a Hypertension, is characterized in that the crude drug that comprises following weight portion makes: Radix Notoginseng 6-10 part, Radix Salviae Miltiorrhizae 15-30 part, Radix Astragali 10-15 part, Rhizoma Gastrodiae 5-10 part, Flos Chrysanthemi 10-15 part, Rhizoma Chuanxiong 5-10 part, Semen Ziziphi Spinosae 10-15 part.
2. Chinese medicine preparation as claimed in claim 1, is characterized in that the crude drug that comprises following weight portion makes: Radix Notoginseng 8-10 part, Radix Salviae Miltiorrhizae 15-20 part, Radix Astragali 12-15 part, Rhizoma Gastrodiae 6-10 part, Flos Chrysanthemi 12-15 part, Rhizoma Chuanxiong 5-8 part, Semen Ziziphi Spinosae 12-15 part.
3. Chinese medicine preparation as claimed in claim 1, is characterized in that 6 parts of Radix Notoginseng, 15 parts of Radix Salviae Miltiorrhizaes, 10 parts of the Radixs Astragali, 5 parts, Rhizoma Gastrodiae, 10 parts of Flos Chrysanthemis, 5 parts of Rhizoma Chuanxiongs, 10 parts of Semen Ziziphi Spinosaes.
4. Chinese medicine preparation as claimed in claim 1, is characterized in that 7 parts of Radix Notoginseng, 18 parts of Radix Salviae Miltiorrhizaes, 12 parts of the Radixs Astragali, 8 parts, Rhizoma Gastrodiae, 13 parts of Flos Chrysanthemis, 7 parts of Rhizoma Chuanxiongs, 11 parts of Semen Ziziphi Spinosaes.
5. Chinese medicine preparation as claimed in claim 1, is characterized in that 10 parts of Radix Notoginseng, 30 parts of Radix Salviae Miltiorrhizaes, 15 parts of the Radixs Astragali, 10 parts, Rhizoma Gastrodiae, 15 parts of Flos Chrysanthemis, 10 parts of Rhizoma Chuanxiongs, 15 parts of Semen Ziziphi Spinosaes.
6. Chinese medicine preparation as claimed in claim 1, is characterized in that 8 parts of Radix Notoginseng, 20 parts of Radix Salviae Miltiorrhizaes, 12 parts of the Radixs Astragali, 8 parts, Rhizoma Gastrodiae, 12 parts of Flos Chrysanthemis, 8 parts of Rhizoma Chuanxiongs, 12 parts of Semen Ziziphi Spinosaes.
7. the described Chinese medicine preparation of aforementioned any one, is characterized in that it can adopt conventional pulverizing or prepare pharmaceutically acceptable any dosage forms such as pharmaceutically acceptable tablet, capsule, microsphere, micropill through conventional extraction separation method.
8. the described Chinese medicine preparation of aforementioned any one, it is characterized in that it can adopt following method preparation: the Radix Notoginseng, Radix Salviae Miltiorrhizae, the Radix Astragali, Rhizoma Gastrodiae, Flos Chrysanthemi, Rhizoma Chuanxiong, the Semen Ziziphi Spinosae that take recipe quantity, the above-mentioned raw materials medicine is cleaned to post-drying, after pulverizing respectively with Universalpulverizer under aseptic, dustless condition, decoct with water 3 times, the water that adds respectively 8 times, 6 times, 4 times amounts, decocting time is respectively 3 hours, 2 hours, 2 hours, merging filtrate concentrating under reduced pressure, drying obtain extract powder, add conventional adjuvant, make pharmaceutically acceptable various dosage form.
9. Chinese medicine preparation as described as claim 1-8 is in preparation treatment blood fat, blood glucose, blood pressure, the application in enhancing immunity, strengthening the spleen and nourishing the stomach medicine.
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| CN105770496A (en) * | 2016-04-08 | 2016-07-20 | 烟台市蓝洋之草医药生物科技有限公司 | Pharmaceutical composition for treating high blood pressure |
| CN110833594A (en) * | 2019-11-11 | 2020-02-25 | 朱德胜 | Medicine for treating cerebral infarction and preparation method thereof |
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