CN101683459B - Application of a traditional Chinese medicine composition in preparation of medicament for treating sleep disorder - Google Patents

Abstract

The invention provides application of a traditional Chinese medicine composition in preparation of medicament for treating sleep disorder, clinical experiments show that, the medicine composition has function of boosting qi and nourishing yin, promoting blood circulation and removing obstruction in channels, purifyring heart and tranquilization, which can be used to treat sleep disorder, and improve sleep-wake schedule with excellent treatment effect.

Description

The application of a kind of Chinese medicine composition in preparation treatment sleep disorder medicine

Technical field

The present invention relates to the application of a kind of Chinese medicine composition in preparation treatment sleep disorder medicine.Belong to the Chinese herbal and crude drugs preparations technical field.

Background technology

The performance of Deviant Behavior occurring in the undesired and sleep of amount of sleep, also is the alternately disorderly performance of sleep and awakening normal rhythm.Can be caused by many factors, normal relevant with physical disease.

Amount of sleep undesired, can comprise two classes: a class is that amount of sleep excessively increases, such as Somnolence or the lethargy that causes because of various encephalopathys, dyshormonia, Developmental and Metabolic Disorder, and because of the caused narcolepsy of cerebral lesion, this disease of sleeping shows as the narcolepsy that short time (generally less than 15 minutes) irresistible property often occurs, often with fall down, the symptom such as sleep paralysis and hypnagogic hallucination; Another kind of is the insomnia of amount of sleep deficiency, the SAN time is less than 5 hours, show as difficulty falling asleep, shallow sleeping, easily wake up or early awakening etc., insomnia can by the external environment factor (indoor light crosses by force, on every side too much noisiness, on night duty, by bus ship, just to the unfamiliar place), Physical factors (pain, pruritus, acutely cough, sleep front drink strong tea or coffee, nocturia is frequent or diarrhoea etc.) or psychological factor (anxiety, fear, excessively miss or excitement) causes.Some diseases is also often with insomnia, such as neurasthenia, anxiety, depression etc.

Some Deviant Behavioies appear in the ictal unusual finger in the sleep in sleep, as somnambulism, somniloquy (talking in one's dream), fright at night (in sleep, be in a tumult suddenly, scream, palpitating speed, rapid breathing, whole body go out, orientation disturbance or hallucination appears), nightmare (having nightmares), grind one's teeth in sleep, independently do not laugh at, muscle or limbs independently do not beat etc.These ictal Deviant Behavioies are not to appear in the SAN, and are mostly to occur in certain sleep period.For example, sleep-walking and fright at night mostly occurred in the later stage of orthodox sleep; The mid-term of orthodox sleep then is more common in somniloquy, or even early stage; Grind one's teeth in sleep, independently do not laugh at, muscle or limbs are beated etc. is more common in early stage of orthodox sleep; Nightmare is many to be occurred in the paradoxical sleep phase.

Sleep-wake schedule disorder refers to sleep-wake rhythms and desiredly is not inconsistent, and causes the discontented situation that continues to sleep quality, and patient has worry or the feared state of mind to this, and causes the ergasia decrease in efficiency, hinders social function.This disease is not the part of any physical disease or mental disorder symptom.If sleep-wake schedule disorder is an ingredient of certain physical disease or mental disorder (such as depression) symptom, be not diagnosed as in addition sleep-wake schedule disorder.Sleep-wake schedule disorder belongs to a kind of typing of sleep disorder.

To adopting western medicine, such as stable and chlordiazepoxide, but the stable class medicine of long-term taking has similar morphine and becomes sick characteristics for sleep disorder.In case addiction if do not continue to take medicine, withdrawal symptom can occur, such as excited, irritability, melancholy even hallucination occurs and killed thought.The old people takes such medicine, because old people's immunologic function is low, hepatic and renal function is poor, easily accumulate poisoning.

The present invention is the improvement invention of carrying out on the basis of ZL02146572.X patent application, quotes in full the content of this patent document record at this.

Summary of the invention

The purpose of this invention is to provide the application of this Chinese medicine composition in preparation treatment sleep disorder medicine.It is characterized in that this Chinese medicine composition is made by the crude drug of following weight portion:

Radix Ginseng 45-180 part, Radix Ophiopogonis 50-200 part, Fructus Corni 125-450 part, Radix Salviae Miltiorrhizae 125-450 part, Semen Ziziphi Spinosae (parched) 95-400 part, Herba Taxilli 95-400 part, Radix Paeoniae Rubra 45-200 part, Eupolyphaga Seu Steleophaga 35-150 part, Radix Et Rhizoma Nardostachyos 45-200 part, Rhizoma Coptidis 25-90 part, Fructus Schisandrae Sphenantherae 35-150 part, Os Draconis 75-300 part.

The weight ratio of Chinese medicine composition Raw medicine of the present invention is preferably:

89 parts of Radix Ginsengs, 112 parts of Radix Ophiopogonis, 224 parts of Fructus Corni, 224 parts of Radix Salviae Miltiorrhizaes, 186 parts of Semen Ziziphi Spinosae (parched)s, 186 parts of Herba Taxillis, 89 parts of Radix Paeoniae Rubra, 75 parts of Eupolyphaga Seu Steleophagas, 89 parts of Radix Et Rhizoma Nardostachyos, 45 parts of Rhizoma Coptidis, 67 parts of Fructus Schisandrae Sphenantheraes, 149 parts of Os Draconis.

The weight ratio of Chinese medicine composition Raw medicine of the present invention also is preferably:

45 parts of Radix Ginsengs, 112 parts of Radix Ophiopogonis, 224 parts of Fructus Corni, 225 parts of Radix Salviae Miltiorrhizaes, 186 parts of Semen Ziziphi Spinosae (parched)s, 186 parts of Herba Taxillis, 89 parts of Radix Paeoniae Rubra, 45 parts of Radix Et Rhizoma Nardostachyos, 35 parts of Eupolyphaga Seu Steleophagas, 45 parts of Rhizoma Coptidis, 67 parts of Fructus Schisandrae Sphenantheraes, 149 parts of Os Draconis.

The weight ratio of Chinese medicine composition Raw medicine of the present invention also is preferably:

90 parts of Radix Ginsengs, 135 parts of Radix Ophiopogonis, 270 parts of Fructus Corni, 200 parts of Radix Salviae Miltiorrhizaes, 150 parts of Semen Ziziphi Spinosae (parched)s, 150 parts of Herba Taxillis, 100 parts of Radix Paeoniae Rubra, 100 parts of Eupolyphaga Seu Steleophagas, 95 parts of Radix Et Rhizoma Nardostachyos, 60 parts of Rhizoma Coptidis, 75 parts of Fructus Schisandrae Sphenantheraes, 150 parts of Os Draconis.

In the application of the present invention, the active component of this Chinese medicine composition is made by the following step:

A) people participates in 70% alcohol reflux three times, and merge extractive liquid, filters, and is concentrated, oven dry, the fine powder that is ground into;

B) Fructus Schisandrae Sphenantherae, Fructus Corni, Radix Salviae Miltiorrhizae, Rhizoma Coptidis, Radix Et Rhizoma Nardostachyos add 70% alcohol reflux 3 times jointly, and merge extractive liquid, filters, concentrated extractum;

C) fine powder that is broken into of Eupolyph aga sinesis Walker;

D) Radix Ophiopogonis, Semen Ziziphi Spinosae (parched), Herba Taxilli, Radix Paeoniae Rubra, Os Draconis decoct with water 2 times, merge extractive liquid,, concentrated extractum;

E) with step b) and d) gained extractum merge, add step c) fine drug powder of gained, oven dry is ground into fine powder, adds a) gained fine drug powder of step, mixing namely gets this Chinese medicine composition active component.

In the application of the present invention, described Chinese medicine composition is capsule, tablet, electuary, a kind of in powder or the oral liquid formulations, for above-mentioned dosage form can be realized, need when these dosage forms of preparation, to add the acceptable adjuvant of pharmacy, for example: filler, disintegrating agent, lubricant, suspending agent, binding agent, sweeting agent, correctives, antiseptic etc., filler comprises: starch, pregelatinized Starch, lactose, mannitol, chitin, microcrystalline Cellulose, sucrose etc., disintegrating agent comprises: starch, pregelatinized Starch, microcrystalline Cellulose, carboxymethyl starch sodium, crospolyvinylpyrrolidone, low-substituted hydroxypropyl cellulose, cross-linking sodium carboxymethyl cellulose etc., lubricant comprises: magnesium stearate, sodium lauryl sulphate, Pulvis Talci, silicon dioxide etc., suspending agent comprises: polyvinylpyrrolidone, microcrystalline Cellulose, sucrose, agar, hydroxypropyl emthylcellulose etc., binding agent comprises, starch slurry, polyvinylpyrrolidone, hydroxypropyl emthylcellulose etc., sweeting agent comprises: saccharin sodium, Aspartane, sucrose, cyclamate, enoxolone etc., correctives comprises: sweeting agent and various essence, and antiseptic comprises: parabens, benzoic acid, sodium benzoate, sorbic acid and its esters, benzalkonium bromide, the acetic acid chloroethene is fixed, the Folium eucalypti globueli (Eucalyptus globulus Labill.) wet goods.

Above-described medicine capsule, its preparation method are to be made by following steps:

A) people participates in 8 times of amount 70% alcohol reflux three times, and 3 hours for the first time, each 2 hours later on, merge extractive liquid, filtered, and Recycled ethanol is concentrated, and oven dry is ground into 80 order fine powders;

B) Fructus Schisandrae Sphenantherae, Fructus Corni, Radix Salviae Miltiorrhizae, Rhizoma Coptidis, Radix Et Rhizoma Nardostachyos add 8 times of amount 70% alcohol reflux 3 times, and merge extractive liquid, filters Recycled ethanol;

C) Eupolyphaga seu Steleophaga is ground into 80 order fine powders;

D) Radix Ophiopogonis, Semen Ziziphi Spinosae (parched), Herba Taxilli, Radix Paeoniae Rubra, Os Draconis add 9 times of amount decoctions of water 2 times, merge extractive liquid,, filtering, with step b) extracting solution of gained merges, and is condensed into extractum, add step c) the gained fine powder, oven dry is ground into 80 order fine powders, adds a) gained fine powder of step, mixing, encapsulated and get final product.

The consumption of Chinese medicine composition of the present invention by active component crude drug gross weight, is 7-28 grams/day, but takes every day once, preferably divides and takes for 2-4 time.

It is remarkable that medicine of the present invention is used for the treatment of the sleep disorder effect, adds on the basis of Primary Care and use medicine of the present invention, and total effective rate can reach 90%, and the effect that is better than using merely Western medicine evident in efficacy.The curative effect of the medicine improvement sleep awakening rhythm and pace of moving things of the present invention is highly significant also, add on the basis of Primary Care and to use medicine of the present invention, total effective rate can reach 95%, and the effect that is better than using merely Western medicine evident in efficacy, so Chinese medicine composition of the present invention is preferably the application in preparation improvement sleep awakening rhythm and pace of moving things medicine.

In the clinical trial of all medicines of the present invention of having finished, all finding to add with remarkable behind the medicine of the present invention increases adverse reaction rate, so medicine of the present invention does not have remarkable untoward reaction.

Essence for a better understanding of the present invention below by the result of the test of this pharmaceutical composition of clinical observation at " treatment sleep disorder, the improvement sleep awakening rhythm and pace of moving things ", illustrates that it is in the new purposes of pharmaceutical field.

Experimental example 1

1 data and method

1.1 the physical data all cases all is selected from Hebei Yi Ling hospital ward patient, amounts to 80 examples, and the patient is divided into treatment group and matched group at random.Treatment group 40 examples, male 16 examples, women 24 examples, 18～70 years old age, average (38 ± 6.7) year, course of disease January～7.8 years.Matched group 40 examples, male 17 examples, women 23 examples, 18～70 years old age, average (37.5 ± 3.5) year, course of disease February～8.0 year.By statistics, two groups at the aspect there was no significant differences such as sex, age, the course of disease (P〉0.05), has comparability.

1.2 case is selected inclusion criteria: the standard that meets insomnia in " classification of Chinese Spirit obstacle diagnosis and standard ", namely take sleep disorder as almost unique symptom, other symptoms all are secondary to insomnia, comprise have difficulty in going to sleep, insomnia-middle, easily wake up, dreaminess, tired or daytime are sleepy etc.; Sleep disorder occurs weekly 3 times at least, and more than lasting January; Insomnia causes significant worries, or the ergasia decrease in efficiency, or hinders social function.Exclusion standard: get rid of physical disease or mental disorder.

1.3 the Therapeutic Method matched group is taken before using stable 2.5-5mg to sleep.Treatment group adds on the matched group basis uses medicine of the present invention, and 4 tablets/times, 3 times/days.Be 20 days the course for the treatment of.

1.4 observation index: relatively sleep disorder scale (SDRS) scoring changes.

1.5 curative effect determinate standard: to subtract minute rate as curative effect index before and after the SDRS total points treatment.Subtract a minute rate=front total points of (total points after total points before the treatment-treatment)/treatment.Subtract a minute rate〉75% for the recovery from illness, 50%～75% be produce effects, 25%～49% for the improvement,＜25% is invalid.Clinical symptoms and sign: select the sings and symptomses such as dizziness and tinnitus, dry mouth and throat, feverish sensation in the palms and soles, palpitation and amnesia, color of the lip pulse condition by without, light, in, heavy delamination criterion, counted respectively 0,1,2,3 minute, with total points Estimating curative effect result.

1.6 statistical procedures adopts the SPSS13.0 statistical software to carry out date processing, (x ± s) expression adopts the t check to measurement data, and enumeration data adopts x with mean ± standard deviation ²Check.

2 results

2.1 Clinical efficacy comparison by statistics, treatment group patient's total effective rate is apparently higher than matched group (P＜0.05).The results are shown in Table 1.

Table 1 liang group patient clinical curative effect is (%) relatively

Annotate: * and # compare, P＜0.05.

2.2SDRS change by statistics before and after the scoring treatment, treatment group is compared with matched group, the SDRS scoring obviously reduces (P＜0.05).The results are shown in Table 2.

The comparison of table 2 liang group patient SDRS scoring (x ± s)

Annotate: * and # be P＜0.05 relatively.

3 conclusions

This research adds Drug therapy of the present invention on the basis of doctor trained in Western medicine conventional therapy, all be better than simple western medical treatment at aspects such as improving clinical efficacy, reduction SDRS scoring, and fully proved invention medicine has significant clinical efficacy to sleep disorder.

Test example 2

1 data and method

1.1 the physical data all cases all is selected from Hebei Yi Ling hospital ward patient, amounts to 80 examples, and the patient is divided into treatment group and matched group at random.Treatment group 40 examples, male 13 examples, women 27 examples; Year mean age (40.01 soil 12.05); Average sick (the 21.45 soil 5.26) moon.Matched group 40 examples, male 14 examples, women 26 examples; Year mean age (39.63 scholar 11.91); Average course of disease (the 20.24 scholar 10.87) moon.By statistics, two groups at the aspect there was no significant differences such as sex, age, the course of disease (P〉0.05), has comparability.

1.2 case is selected inclusion criteria: become without encephalosis, it is the main symptom person that sleep every day is less than 240～300min.

1.3 the Therapeutic Method matched group is taken before using chlordiazepoxide 10～20mg to sleep.Treatment group adds on the matched group basis uses medicine of the present invention, and 4 tablets/times, 3 times/days.Be 20 days the course for the treatment of.

1.4 observation index: relatively sleep disorder scale (SDRS) scoring changes.

1.5 curative effect determinate standard: to subtract minute rate as curative effect index before and after the SDRS total points treatment.Subtract a minute rate=front total points of (total points after total points before the treatment-treatment)/treatment.Subtract a minute rate〉75% for the recovery from illness, 50%～75% be produce effects, 25%～49% for the improvement,＜25% is invalid.Clinical symptoms and sign: select the sings and symptomses such as dizziness and tinnitus, dry mouth and throat, feverish sensation in the palms and soles, palpitation and amnesia, color of the lip pulse condition by without, light, in, heavy delamination criterion, counted respectively 0,1,2,3 minute, with total points Estimating curative effect result.

1.6 statistical procedures adopts the SPSS13.0 statistical software to carry out date processing, (x ± s) expression adopts the t check to measurement data, and enumeration data adopts x with mean ± standard deviation ²Check.

2 results

2.1 Clinical efficacy comparison by statistics, treatment group patient's total effective rate is apparently higher than matched group (P＜0.05).The results are shown in Table 3.

Table 3 liang group patient clinical curative effect is (%) relatively

Annotate: * and # compare, P＜0.05.

2.2SDRS change by statistics before and after the scoring treatment, treatment group is compared with matched group, the SDRS scoring obviously reduces (P＜0.05).The results are shown in Table 4.

The comparison of table 4 liang group patient SDRS scoring (x ± s)

Annotate: * and # compare, P＜0.05.

3 conclusions

This research adds Drug therapy of the present invention on the basis of doctor trained in Western medicine conventional therapy, all be better than simple western medical treatment at aspects such as improving clinical efficacy, reduction SDRS scoring, and fully proved invention medicine has significant clinical efficacy to improving the sleep awakening rhythm and pace of moving things.

The specific embodiment

Following embodiment is used for illustrating the preparation of Chinese medicine composition of the present invention, but it can not consist of any restriction to scope of the present invention.

Embodiment 1

For the ease of the application of this Chinese medicine composition, this Chinese medicine composition is prepared as capsule

Prescription:

Radix Ginseng 89g 112g Radix Ophiopogonis Fructus Corni 224g Radix Salviae Miltiorrhizae 224g

Semen Ziziphi Spinosae (parched) 186g Herba Taxilli 186g Radix Paeoniae Rubra 89g Eupolyphaga Seu Steleophaga 75g

Radix Et Rhizoma Nardostachyos 89g Rhizoma Coptidis 45g Fructus Schisandrae Sphenantherae 67g Os Draconis 149g

Preparation method:

A) in the above-mentioned prescription, Radix Ginseng is with 70% alcohol reflux three times, and 3 hours for the first time, each 2 hours later on, merge extractive liquid, filtered, and Recycled ethanol is concentrated, and oven dry is ground into fine powder, and is for subsequent use;

B) in the above-mentioned prescription, Fructus Schisandrae Sphenantherae, Fructus Corni, Radix Salviae Miltiorrhizae, Rhizoma Coptidis, Radix Et Rhizoma Nardostachyos are with 70% alcohol reflux three times, and merge extractive liquid, filters, and is for subsequent use;

C) in the above-mentioned prescription, Eupolyph aga sinesis Walker is broken into fine powder, and is for subsequent use;

D) in the above-mentioned prescription, Radix Ophiopogonis, Semen Ziziphi Spinosae (parched), Herba Taxilli, Radix Paeoniae Rubra, Os Draconis decoct with water secondary, and merge extractive liquid, filters filtrate and step b) merging of gained extracting solution, the concentrated extractum that to get, for subsequent use;

E) with steps d) gained extractum, add step c) the fine drug powder oven dry of gained, and be ground into fine powder, add a) gained fine drug powder of step, mixing, 1000 capsules of packing into.

Usage and consumption: oral.One time 2～4,3 times on the one.

Embodiment 2

For the ease of the application of this Chinese medicine composition, this Chinese medicine composition is prepared as tablet

Prescription:

Radix Ginseng 45g 112g Radix Ophiopogonis Fructus Corni 224g Radix Salviae Miltiorrhizae 225g

Semen Ziziphi Spinosae (parched) 186g Herba Taxilli 186g Radix Paeoniae Rubra 89g Radix Et Rhizoma Nardostachyos 45g

Eupolyphaga Seu Steleophaga 35g Rhizoma Coptidis 45g Fructus Schisandrae Sphenantherae 67g Os Draconis 149g

Preparation method:

A) in the above-mentioned prescription, Radix Ginseng is with 70% alcohol reflux three times, and 3 hours for the first time, each 2 hours later on, merge extractive liquid, filtered, and Recycled ethanol is concentrated, and oven dry is ground into fine powder, and is for subsequent use;

B) in the above-mentioned prescription, Fructus Schisandrae Sphenantherae, Fructus Corni, Radix Salviae Miltiorrhizae, Rhizoma Coptidis, Radix Et Rhizoma Nardostachyos are with 70% alcohol reflux three times, and merge extractive liquid, filters, and is for subsequent use;

C) in the above-mentioned prescription, Eupolyph aga sinesis Walker is broken into fine powder, and is for subsequent use;

D) in the above-mentioned prescription, Radix Ophiopogonis, Semen Ziziphi Spinosae (parched), Herba Taxilli, Radix Paeoniae Rubra, Os Draconis decoct with water secondary, and merge extractive liquid, filters filtrate and step b) merging of gained extracting solution, the concentrated extractum that to get, for subsequent use;

E) with steps d) gained extractum, add step c) the fine drug powder oven dry of gained, and be ground into fine powder, add a) gained fine drug powder of step, mixing, preparation process is pressed into 1000 routinely.Usage and consumption: oral.One time 2～4,3 times on the one.

Embodiment 3

For the ease of the application of this Chinese medicine composition, this Chinese medicine composition is prepared as granule

Prescription:

Radix Ginseng 90g 135g Radix Ophiopogonis Fructus Corni 270g Radix Salviae Miltiorrhizae 200g

Semen Ziziphi Spinosae (parched) 150g Herba Taxilli 150g Radix Paeoniae Rubra 100g Eupolyphaga Seu Steleophaga 100g

Radix Et Rhizoma Nardostachyos 95g Rhizoma Coptidis 60g Fructus Schisandrae Sphenantherae 75g Os Draconis 150g

Preparation method:

A) in the above-mentioned prescription, Radix Ginseng is with 70% alcohol reflux three times, and 3 hours for the first time, each 2 hours later on, merge extractive liquid, filtered, and Recycled ethanol is concentrated, and oven dry is ground into fine powder, and is for subsequent use;

B) in the above-mentioned prescription, Fructus Schisandrae Sphenantherae, Fructus Corni, Radix Salviae Miltiorrhizae, Rhizoma Coptidis, Radix Et Rhizoma Nardostachyos are with 70% alcohol reflux three times, and merge extractive liquid, filters, and is for subsequent use;

C) in the above-mentioned prescription, Eupolyph aga sinesis Walker is broken into fine powder, and is for subsequent use;

D) in the above-mentioned prescription, Radix Ophiopogonis, Semen Ziziphi Spinosae (parched), Herba Taxilli, Radix Paeoniae Rubra, Os Draconis decoct with water secondary, and merge extractive liquid, filters filtrate and step b) merging of gained extracting solution, the concentrated extractum that to get, for subsequent use;

E) with steps d) gained extractum, add step c) the fine drug powder oven dry of gained, and be ground into fine powder, add a) gained fine drug powder of step, mixing is made 1000 bags of granules according to conventional formulation.

Usage and consumption: oral.One time 2～4 bags, 3 times on the one.

Claims (7)

1. the application of Chinese medicine composition in preparation treatment sleep disorder medicine, this Chinese medicine composition is made by the crude drug of following weight portion:

Radix Ginseng 45-180 part, Radix Ophiopogonis 50-200 part, Fructus Corni 125-450 part, Radix Salviae Miltiorrhizae 125-450 part, Semen Ziziphi Spinosae (parched) 95-400 part, Herba Taxilli 95-400 part, Radix Paeoniae Rubra 45-200 part, Eupolyphaga Seu Steleophaga 35-150 part, Radix Et Rhizoma Nardostachyos 45-200 part, Rhizoma Coptidis 25-90 part, Fructus Schisandrae Sphenantherae 35-150 part, Os Draconis 75-300 part;

It is characterized in that described treatment sleep disorder medicine is for improving the medicine of the sleep awakening rhythm and pace of moving things.

2. application as claimed in claim 1 is characterized in that, this Chinese medicine composition is made by the crude drug of following weight portion:

89 parts of Radix Ginsengs, 112 parts of Radix Ophiopogonis, 224 parts of Fructus Corni, 224 parts of Radix Salviae Miltiorrhizaes, 186 parts of Semen Ziziphi Spinosae (parched)s, 186 parts of Herba Taxillis, 89 parts of Radix Paeoniae Rubra, 75 parts of Eupolyphaga Seu Steleophagas, 89 parts of Radix Et Rhizoma Nardostachyos, 45 parts of Rhizoma Coptidis, 67 parts of Fructus Schisandrae Sphenantheraes, 149 parts of Os Draconis.

3. application as claimed in claim 1 is characterized in that, this Chinese medicine composition is made by the crude drug of following weight portion:

45 parts of Radix Ginsengs, 112 parts of Radix Ophiopogonis, 224 parts of Fructus Corni, 225 parts of Radix Salviae Miltiorrhizaes, 186 parts of Semen Ziziphi Spinosae (parched)s, 186 parts of Herba Taxillis, 89 parts of Radix Paeoniae Rubra, 45 parts of Radix Et Rhizoma Nardostachyos, 35 parts of Eupolyphaga Seu Steleophagas, 45 parts of Rhizoma Coptidis, 67 parts of Fructus Schisandrae Sphenantheraes, 149 parts of Os Draconis.

4. application as claimed in claim 1 is characterized in that, this Chinese medicine composition is made by the crude drug of following weight portion:

90 parts of Radix Ginsengs, 135 parts of Radix Ophiopogonis, 270 parts of Fructus Corni, 200 parts of Radix Salviae Miltiorrhizaes, 150 parts of Semen Ziziphi Spinosae (parched)s, 150 parts of Herba Taxillis, 100 parts of Radix Paeoniae Rubra, 100 parts of Eupolyphaga Seu Steleophagas, 95 parts of Radix Et Rhizoma Nardostachyos, 60 parts of Rhizoma Coptidis, 75 parts of Fructus Schisandrae Sphenantheraes, 150 parts of Os Draconis.

5. such as each described application among the claim 1-4, it is characterized in that the active component of this Chinese medicine composition is made by the following step:

A) people participates in 70% alcohol reflux three times, and merge extractive liquid, filters, and is concentrated, and oven dry is ground into fine powder;

B) Fructus Schisandrae Sphenantherae, Fructus Corni, Radix Salviae Miltiorrhizae, Rhizoma Coptidis, Radix Et Rhizoma Nardostachyos add 70% alcohol reflux 3 times jointly, and merge extractive liquid, filters, and is for subsequent use;

C) Eupolyph aga sinesis Walker is broken into fine powder;

D) Radix Ophiopogonis, Semen Ziziphi Spinosae (parched), Herba Taxilli, Radix Paeoniae Rubra, Os Draconis decoct with water 2 times, and merge extractive liquid, filters, and is for subsequent use;

E) with step b) and d) the gained extracting solution merge, Recycled ethanol is condensed into extractum, adds step c) fine drug powder of gained, oven dry is ground into fine powder, adds a) gained fine drug powder of step, mixing namely gets this Chinese medicine composition active component.

6. such as each described application among the claim 1-4, it is characterized in that described Chinese medicine composition is capsule, tablet, electuary, powder or oral liquid.

7. application according to claim 6 is characterized in that described capsule is to be made by following steps:

A) people participates in 8 times of amount 70% alcohol reflux three times, and 3 hours for the first time, each 2 hours later on, merge extractive liquid, filtered, and Recycled ethanol is concentrated, and oven dry is ground into 80 order fine powders;

B) Fructus Schisandrae Sphenantherae, Fructus Corni, Radix Salviae Miltiorrhizae, Rhizoma Coptidis, Radix Et Rhizoma Nardostachyos add 8 times of amount 70% alcohol reflux 3 times, and merge extractive liquid, filters Recycled ethanol;

C) Eupolyphaga seu Steleophaga is ground into 80 order fine powders;

D) Radix Ophiopogonis, Semen Ziziphi Spinosae (parched), Herba Taxilli, Radix Paeoniae Rubra, Os Draconis add 9 times of amount decoctions of water 2 times, merge extractive liquid,, filtering, with step b) extracting solution of gained merges, and is condensed into extractum, add step c) the gained fine powder, oven dry is ground into 80 order fine powders, adds a) gained fine powder of step, mixing, encapsulated and get final product.