CN101632782B - Application of Chinese medicinal composition in preparing medicament for treating chronic fatigue syndrome - Google Patents

Abstract

The invention provides application of a Chinese medicinal composition in preparing a medicament for treating chronic fatigue syndrome. The Chinese medicinal composition comprises ginseng, dwarf lilyturf root, dogberry, salvia miltiorrhiza, fried spina date seed, Chinese taxillus twig, red paeony root, ground beeltle, nardostachyos root and rhizome and other Chinese medicaments. The clinical experiments prove that Chinese medicinal composition has obvious clinical curative effect of treating the chronic fatigue syndrome.

Description

The application of a kind of Chinese medicine composition in preparation treatment chronic fatigue syndrome medicament

Technical field

The present invention relates to the application of a kind of Chinese medicine composition in preparation treatment chronic fatigue syndrome medicament, belong to the Chinese herbal medicine application.

Background technology

Chronic fatigue syndrome be a group of occurring under the modern fast pace life style with long-term extremely tired be the general syndrome of outstanding behaviours; Can be with dizziness, headache, insomnia, forgetful, low grade fever, muscle arthralgia and multiple neural mental symptom; Basic feature can not be alleviated after having a rest, and physico-chemical examination does not have organic disease.So far, modern medicine still lacks effective treatment means.

The cause of disease of chronic fatigue syndrome thinks with overworked, spiritual high-pressure, diet for a long time more and trophic structure is unreasonable, life nerve, endocrine, immunologic dysfunction irregular and that stress cause is relevant.Chronic fatigue syndrome is often brought out by important life events (great psychic trauma etc.) or psychology, social stress etc., and also possibly there is certain personality liability in this explanation patient.Domestic research report, there is psychological abnormality in nearly 70% chronic fatigue syndrome patient, mainly shows as symptoms such as contention, changeable in mood, depression and anxiety, especially demonstrate to ownly be unsatisfied with, the shortage security and social identity sense.Therefore, having quite a few patient is on the basis of certain nature factor, and negative life events has caused the generation of chronic fatigue syndrome as initiating agent.

Tradition usually be described as fatigue in the traditional Chinese medical science ' laziness ", " slacking off ", " body weight ", " extremity are heavy ", " inability to raise the limbs " etc." Bulbus Lilii syndrome ", " hysteria ", " deficient ", " " asthenia ", " melancholia " etc. have and chronic fatigue syndrome coincide relevant symptoms.The sick position of chronic fatigue syndrome is at conscience spleen kidney, and pathogenesis is main with simulataneous insufficiency and excessive, and its void mainly is the deficiency of vital energy, is mainly stagnation of liver-QI in fact.The reciprocal causation again of the deficiency of vital energy and stagnation of liver-QI.Heart storing spirit, excessive thinking and anxiety, the motive is lost then physical fatigue and lassitude of spirit of void, insomnia and dreamful sleep, palpitation and amnesia, labor is then more so; Overworked, damage temper, source of generating QI and blood is not enough, and limb muscle loses supports, then fatigue and weakness, the discomfort of aching; Kidney storing essence, congenital deficiency of kidney-essence or the day after tomorrow excess of sexual intercourse, the consumption essence of being impairment of the kidney, the vital essence of kidney is not enough, then lethargy is sleepy drowsiness, soreness of the waist and knees; " element is asked the flaccidity opinion " said: " the liver being in charge of the tendons ", liver governing tendons is source of endurance, and feelings will is unsuccessful, can cause stagnation of QI due to depression of the liver, and the vexed anorexia of gastral cavity, dreaminess, symptoms such as susceptible to lose temper due to restlessness fullness and distention in the chest and hypochondrium appears, in the catharsis dereliction of duty; Symptoms such as low grade fever, agitation, headache, feeling of fullness in the head then appear in stagnated QI transforming into fire.

Owing to still be difficult to confirm unusual cause effect relation before such as chronic fatigue syndrome and viral infection, immune system, hormonal system and metabolic activity etc. so far, so have influence on its treatment.Doctor trained in Western medicine mainly adopts the method for symptomatic treatment to come the symptom of reduction of patient to the treatment of chronic fatigue syndrome at present, as adopting antiviral agents, immunomodulator, antidepressants and tranquilizer etc., still can't obtain satisfied curative effect.

The Chinese medicine chronic fatigue syndrome is through the conditioning viscera function, and the inherent mechanism of adjustment body reaches therapeutic purposes, has its special advantages, and is evident in efficacy.

Patent ZL02146572.X discloses a kind of pharmaceutical composition of treating Coronary heart disease ventricular early throb and preparation method thereof, and present patent application quotes in full the content that patent ZL02146572.X is put down in writing.The application of unexposed this pharmaceutical composition of this patent in preparation treatment chronic fatigue syndrome medicament.

Summary of the invention

The purpose of this invention is to provide the application of a kind of Chinese medicine composition in preparation treatment chronic fatigue syndrome medicament, this Chinese medicine composition is processed by following bulk drugs:

Radix Ginseng 45-180 part, Radix Ophiopogonis 50-200 part, Fructus Corni 125-450 part, Radix Salviae Miltiorrhizae 125-450 part, Semen Ziziphi Spinosae (parched) 95-400 part, Herba Taxilli 95-400 part, Radix Paeoniae Rubra 45-200 part, Eupolyphaga Seu Steleophaga 35-150 part, Radix Et Rhizoma Nardostachyos 45-200 part, Rhizoma Coptidis 25-90 part, Fructus Schisandrae Sphenantherae 35-150 part, Os Draconis 75-300 part.

The weight ratio of crude drug is preferably in the Chinese medicine composition of the present invention:

89 parts of Radix Ginsengs, 112 parts of Radix Ophiopogonis, 224 parts of Fructus Corni, 224 parts of Radix Salviae Miltiorrhizaes, 186 parts of Semen Ziziphi Spinosae (parched)s, 186 parts of Herba Taxillis, 89 parts of Radix Paeoniae Rubra, 75 parts of Eupolyphaga Seu Steleophagas, 89 parts of Radix Et Rhizoma Nardostachyos, 45 parts of Rhizoma Coptidis, 67 parts of Fructus Schisandrae Sphenantheraes, 149 parts of Os Draconis.

The weight ratio of crude drug also is preferably in the Chinese medicine composition of the present invention:

45 parts of Radix Ginsengs, 112 parts of Radix Ophiopogonis, 224 parts of Fructus Corni, 225 parts of Radix Salviae Miltiorrhizaes, 186 parts of Semen Ziziphi Spinosae (parched)s, 186 parts of Herba Taxillis, 89 parts of Radix Paeoniae Rubra, 45 parts of Radix Et Rhizoma Nardostachyos, 35 parts of Eupolyphaga Seu Steleophagas, 45 parts of Rhizoma Coptidis, 67 parts of Fructus Schisandrae Sphenantheraes, 149 parts of Os Draconis.

The weight ratio of crude drug also is preferably in the Chinese medicine composition of the present invention:

90 parts of Radix Ginsengs, 135 parts of Radix Ophiopogonis, 270 parts of Fructus Corni, 200 parts of Radix Salviae Miltiorrhizaes, 150 parts of Semen Ziziphi Spinosae (parched)s, 150 parts of Herba Taxillis, 100 parts of Radix Paeoniae Rubra, 100 parts of Eupolyphaga Seu Steleophagas, 95 parts of Radix Et Rhizoma Nardostachyos, 60 parts of Rhizoma Coptidis, 75 parts of Fructus Schisandrae Sphenantheraes, 150 parts of Os Draconis.

In the application of the present invention, the active component of this Chinese medicine composition is processed by the following step:

A) people participates in 70% alcohol reflux three times, and merge extractive liquid, filters, and concentrates, and oven dry is ground into fine powder;

B) Fructus Schisandrae Sphenantherae, Fructus Corni, Radix Salviae Miltiorrhizae, Rhizoma Coptidis, Radix Et Rhizoma Nardostachyos add 70% alcohol reflux 3 times jointly, and merge extractive liquid, filters, and is subsequent use;

C) Eupolyph aga sinesis Walker is broken into fine powder;

D) Radix Ophiopogonis, Semen Ziziphi Spinosae (parched), Herba Taxilli, Radix Paeoniae Rubra, Os Draconis decocte with water 2 times, merge extractive liquid, filters, and is subsequent use;

E) with step b) and d) merging of gained extracting solution, reclaim ethanol, be condensed into extractum, add the fine drug powder of step c) gained, oven dry is ground into fine powder, adds step a) gained fine drug powder, and mixing promptly gets this Chinese medicine composition active component.

In the application of the present invention; Said Chinese medicinal composition preparation dosage form is capsule, tablet, granule, powder or oral liquid; For above-mentioned dosage form can be realized; Need when these dosage forms of preparation, to add the pharmacy acceptable auxiliary; For example: filler, disintegrating agent, lubricant, suspending agent, binding agent, sweeting agent, correctives, antiseptic etc.; Filler comprises: starch, pregelatinized Starch, lactose, mannitol, chitin, microcrystalline Cellulose, sucrose etc., and disintegrating agent comprises: starch, pregelatinized Starch, microcrystalline Cellulose, carboxymethyl starch sodium, crospolyvinylpyrrolidone, low-substituted hydroxypropyl cellulose, cross-linking sodium carboxymethyl cellulose etc., lubricant comprises: magnesium stearate, sodium lauryl sulphate, Pulvis Talci, silicon dioxide etc.; Suspending agent comprises: polyvinylpyrrolidone, microcrystalline Cellulose, sucrose, agar, hydroxypropyl emthylcellulose etc.; Binding agent comprises, starch slurry, polyvinylpyrrolidone, hydroxypropyl emthylcellulose etc., and sweeting agent comprises: saccharin sodium, Aspartane, sucrose, cyclamate, enoxolone etc.; Correctives comprises: sweeting agent and various essence, antiseptic comprises: parabens, benzoic acid, sodium benzoate, sorbic acid and its esters, benzalkonium bromide, fixed, the Folium eucalypti globueli (Eucalyptus globulus Labill.) wet goods of acetic acid chloroethene.

Preferably, the method for preparing of capsule of the present invention is:

A) people participates in 8 times of amount 70% alcohol reflux three times, and 3 hours for the first time, each 2 hours later on, merge extractive liquid, filtered, and reclaims ethanol, concentrates, and oven dry is ground into 80 order fine powders;

B) Fructus Schisandrae Sphenantherae, Fructus Corni, Radix Salviae Miltiorrhizae, Rhizoma Coptidis, Radix Et Rhizoma Nardostachyos add 8 times of amount 70% alcohol reflux 3 times, and merge extractive liquid, filters, and reclaims ethanol;

C) TUBIECHONG is ground into 80 order fine powders;

D) Radix Ophiopogonis, Semen Ziziphi Spinosae (parched), Herba Taxilli, Radix Paeoniae Rubra, Os Draconis add 9 times of amount decoctions of water 2 times, and merge extractive liquid, filters; Merge with the extracting solution of step b) gained, be condensed into extractum, add step c) gained fine powder; Oven dry is ground into 80 order fine powders, adds step a) gained fine powder; Mixing encapsulatedly promptly gets.

Clinical observation shows that Chinese medicine composition of the present invention can effectively be treated chronic fatigue syndrome, and no drug dependence and toleration also have no adverse reaction, and is prone to accepted by the patient.

The consumption of Chinese medicine composition of the present invention by active component crude drug gross weight, is 7-28 gram/day, but takes every day once, preferably divides and takes for 2-4 time.

The specific embodiment

Following embodiment is used to illustrate the preparation of Chinese medicine composition of the present invention, but it can not constitute any restriction to scope of the present invention.

Embodiment 1

For the ease of the application of this traditional Chinese medicine composition for treating chronic fatigue syndrome, this Chinese medicine composition is prepared as capsule

Prescription:

Radix Ginseng 89g 112g Radix Ophiopogonis Fructus Corni 224g Radix Salviae Miltiorrhizae 224g

Semen Ziziphi Spinosae (parched) 186g Herba Taxilli 186g Radix Paeoniae Rubra 89g Eupolyphaga Seu Steleophaga 75g

Radix Et Rhizoma Nardostachyos 89g Rhizoma Coptidis 45g Fructus Schisandrae Sphenantherae 67g Os Draconis 149g

Method for preparing:

A) in the above-mentioned prescription, Radix Ginseng is with 70% alcohol reflux three times, and 3 hours for the first time, each 2 hours later on, merge extractive liquid, filtered, and reclaims ethanol, concentrates, and oven dry is ground into fine powder, and is subsequent use;

B) in the above-mentioned prescription, Fructus Schisandrae Sphenantherae, Fructus Corni, Radix Salviae Miltiorrhizae, Rhizoma Coptidis, Radix Et Rhizoma Nardostachyos are with 70% alcohol reflux three times, and merge extractive liquid, filters, and is subsequent use;

C) in the above-mentioned prescription, Eupolyph aga sinesis Walker is broken into fine powder, and is subsequent use;

D) in the above-mentioned prescription, Radix Ophiopogonis, Semen Ziziphi Spinosae (parched), Herba Taxilli, Radix Paeoniae Rubra, Os Draconis decocte with water secondary, merge extractive liquid, filters, filtrating merges with step b) gained extracting solution, concentrate extractum, subsequent use;

E) with step d) gained extractum, add the fine drug powder oven dry of step c) gained, be ground into fine powder, add step a) gained fine drug powder, mixing, 1000 capsules of packing into.

Usage and consumption: oral.One time 2～4,3 times on the one.

Embodiment 2

For the ease of the application of this traditional Chinese medicine composition for treating chronic fatigue syndrome, this Chinese medicine composition is prepared as tablet

Prescription:

Radix Ginseng 45g 112g Radix Ophiopogonis Fructus Corni 224g Radix Salviae Miltiorrhizae 225g Semen Ziziphi Spinosae (parched) 186g

Herba Taxilli 186g Radix Paeoniae Rubra 89g Radix Et Rhizoma Nardostachyos 45g Eupolyphaga Seu Steleophaga 35g Rhizoma Coptidis 45g

Fructus Schisandrae Sphenantherae 67g Os Draconis 149g.

Method for preparing:

A) in the above-mentioned prescription, Radix Ginseng is with 70% alcohol reflux three times, and 3 hours for the first time, each 2 hours later on, merge extractive liquid, filtered, and reclaims ethanol, concentrates, and oven dry is ground into fine powder, and is subsequent use;

B) in the above-mentioned prescription, Fructus Schisandrae Sphenantherae, Fructus Corni, Radix Salviae Miltiorrhizae, Rhizoma Coptidis, Radix Et Rhizoma Nardostachyos are with 70% alcohol reflux three times, and merge extractive liquid, filters, and is subsequent use;

C) in the above-mentioned prescription, Eupolyph aga sinesis Walker is broken into fine powder, and is subsequent use;

D) in the above-mentioned prescription, Radix Ophiopogonis, Semen Ziziphi Spinosae (parched), Herba Taxilli, Radix Paeoniae Rubra, Os Draconis decocte with water secondary, merge extractive liquid, filters, filtrating merges with step b) gained extracting solution, concentrate extractum, subsequent use;

E) with step d) gained extractum, add the fine drug powder oven dry of step c) gained, be ground into fine powder, add step a) gained fine drug powder, mixing is pressed into 1000 by conventional formulation technology.

Usage and consumption: oral.One time 2～4,3 times on the one.

Embodiment 3

For the ease of the application of this traditional Chinese medicine composition for treating chronic fatigue syndrome, this Chinese medicine composition is prepared as granule

Prescription:

Radix Ginseng 175g 192g Radix Ophiopogonis Fructus Corni 421g Radix Salviae Miltiorrhizae 440g Semen Ziziphi Spinosae (parched) 395g

Herba Taxilli 396g Radix Paeoniae Rubra 188g Eupolyphaga Seu Steleophaga 98g Radix Et Rhizoma Nardostachyos 188g Rhizoma Coptidis 85g

Fructus Schisandrae Sphenantherae 147g Os Draconis 278g.

Method for preparing:

A) in the above-mentioned prescription, Radix Ginseng is with 70% alcohol reflux three times, and 3 hours for the first time, each 2 hours later on, merge extractive liquid, filtered, and reclaims ethanol, concentrates, and oven dry is ground into fine powder, and is subsequent use;

B) in the above-mentioned prescription, Fructus Schisandrae Sphenantherae, Fructus Corni, Radix Salviae Miltiorrhizae, Rhizoma Coptidis, Radix Et Rhizoma Nardostachyos are with 70% alcohol reflux three times, and merge extractive liquid, filters, and is subsequent use;

C) in the above-mentioned prescription, Eupolyph aga sinesis Walker is broken into fine powder, and is subsequent use;

D) in the above-mentioned prescription, Radix Ophiopogonis, Semen Ziziphi Spinosae (parched), Herba Taxilli, Radix Paeoniae Rubra, Os Draconis decocte with water secondary, merge extractive liquid, filters, filtrating merges with step b) gained extracting solution, concentrate extractum, subsequent use;

E) with step d) gained extractum, add the fine drug powder oven dry of step c) gained, be ground into fine powder, add step a) gained fine drug powder, mixing is processed 1000 bags of granules according to conventional formulation.

Usage and consumption: oral.One time 2～4 bags, 3 times on the one.

Experimental example

For illustrating the activity of traditional Chinese medicine composition for treating chronic fatigue syndrome of the present invention, use the capsule (to call medicine of the present invention in the following text) that makes by the foregoing description 1 method to carry out following clinical trial.

1 data and method

1.1 the whole cases of physical data all are selected from Hebei Yi Ling hospital outpatient patient, amount to 72 examples, and the patient is divided into treatment group and matched group at random.36 examples are organized in treatment, wherein male 15 examples, women 21 examples, age 21-49 year, average (40.5 ± 2.1) year, course of disease 0.5-8, average (5.1 ± 0.5) year; Matched group 36 examples, wherein male 16 examples, women 20 examples, age 20-48 year, average (39.5 ± 4.5) year, course of disease 0.5-7.5, average (6.0 ± 2.1) year.Through statistics, two groups of there was no significant differences (P＞0.05) aspect sex, age, the course of disease have comparability.

1.2 case is selected inclusion criteria: meet the diagnostic criteria of U.S. CDC formulation in 1994: the serious fatigue that continues or show effect repeatedly of (1) unknown cause, persistent period were above 6 months; The back symptom of fully having a rest is not alleviated; And present patient's vocational ability; The ability of accepting the education obviously descends before personal lifestyle and social activity ability are more ill; (2) simultaneously or possess 4 in following 8 at least: memory or aprosexia, have sore throat, cervical region or the enlargement of axillary lymph knot, tenderness, muscular soreness, multiple arthralgia, emerging pain, sleep disorder, tired back is tired continues 24 hours; (3) get rid of protopathy because of explainable fatigue; Get rid of chlorpromazine addiction etc.

1.3 two groups of cases of Therapeutic Method all give in good time psychological consultation and the supporting treatment etc. of suiting the medicine to the illness.The treatment group adds on the matched group basis uses medicine of the present invention, and 4/inferior, 3 times/day.Be 1 month the course of treatment.

1.4 curative effect determinate standard: 1. produce effects: be main syndrome complete obiteration with fatigue in two courses of treatment; 2. effective: as to be that main syndrome obviously alleviates with fatigue in two courses of treatment; 3. invalid: no significant change before and after the treatment.

1.5 observation index: the patient is evaluated with fatigue scale (FS-14), self rating depressive scale (SDS) and anxiety self-appraisal scale (SAS).

1.6 statistical procedures adopts the SPSS13.0 statistical software to carry out date processing, (x ± s) expression adopts the t check to measurement data, and enumeration data adopts x with mean ± standard deviation ²Check.

2 results

2.1 relatively through statistics, treatment group patient total effective rate is apparently higher than matched group (P＜0.05) for clinical efficacy.The result sees table 1.

Table 1 liang group patient clinical efficacy is (%) relatively

Annotate: * and # be x relatively ²=4.60, P＜0.05.

2.2 the FS-14 scoring changes through statistics before and after the treatment, the treatment group is compared with matched group, and FS-14 total points, body fatigue and mental fatigue scoring all obviously reduce (P＜0.05).The result sees table 2.

Table 2 liang group patient FS-14 scoring comparison (x ± s)

Annotate: * and # be P＜0.05 relatively.

2.3 SDS and SAS scoring changes through statistics before and after the treatment, the treatment group is compared with matched group, and SDS and SAS scoring obviously reduce (P＜0.05).The result sees table 3.

Table 3 liang group patient SDS and SAS scoring comparison (x ± s)

Annotate: * and # be P＜0.05 relatively.

3 conclusions

This research is on the basis of doctor trained in Western medicine conventional therapy; Add Drug therapy of the present invention; All be superior to simple western medical treatment at aspects such as raising clinical efficacy, reduction FS-14, SDS and SAS scorings, confirm that fully medicine of the present invention has significant clinical efficacy to chronic fatigue syndrome.

Claims (7)

1. the application of Chinese medicine composition in preparation treatment chronic fatigue syndrome medicament is characterized in that this Chinese medicine composition is processed by following bulk drugs:

Radix Ginseng 45-180 part, Radix Ophiopogonis 50-200 part, Fructus Corni 125-450 part, Radix Salviae Miltiorrhizae 125-450 part, Semen Ziziphi Spinosae (parched) 95-400 part, Herba Taxilli 95-400 part, Radix Paeoniae Rubra 45-200 part, Eupolyphaga Seu Steleophaga 35-150 part, Radix Et Rhizoma Nardostachyos 45-200 part, Rhizoma Coptidis 25-90 part, Fructus Schisandrae Sphenantherae 35-150 part, Os Draconis 75-300 part.

2. application as claimed in claim 1 is characterized in that, this Chinese medicine composition is processed by following bulk drugs:

89 parts of Radix Ginsengs, 112 parts of Radix Ophiopogonis, 224 parts of Fructus Corni, 224 parts of Radix Salviae Miltiorrhizaes, 186 parts of Semen Ziziphi Spinosae (parched)s, 186 parts of Herba Taxillis, 89 parts of Radix Paeoniae Rubra, 75 parts of Eupolyphaga Seu Steleophagas, 89 parts of Radix Et Rhizoma Nardostachyos, 45 parts of Rhizoma Coptidis, 67 parts of Fructus Schisandrae Sphenantheraes, 149 parts of Os Draconis.

3. application as claimed in claim 1 is characterized in that, this Chinese medicine composition is processed by following bulk drugs:

45 parts of Radix Ginsengs, 112 parts of Radix Ophiopogonis, 224 parts of Fructus Corni, 225 parts of Radix Salviae Miltiorrhizaes, 186 parts of Semen Ziziphi Spinosae (parched)s, 186 parts of Herba Taxillis, 89 parts of Radix Paeoniae Rubra, 45 parts of Radix Et Rhizoma Nardostachyos, 35 parts of Eupolyphaga Seu Steleophagas, 45 parts of Rhizoma Coptidis, 67 parts of Fructus Schisandrae Sphenantheraes, 149 parts of Os Draconis.

4. application as claimed in claim 1 is characterized in that, this Chinese medicine composition is processed by following bulk drugs:

90 parts of Radix Ginsengs, 135 parts of Radix Ophiopogonis, 270 parts of Fructus Corni, 200 parts of Radix Salviae Miltiorrhizaes, 150 parts of Semen Ziziphi Spinosae (parched)s, 150 parts of Herba Taxillis, 100 parts of Radix Paeoniae Rubra, 100 parts of Eupolyphaga Seu Steleophagas, 95 parts of Radix Et Rhizoma Nardostachyos, 60 parts of Rhizoma Coptidis, 75 parts of Fructus Schisandrae Sphenantheraes, 150 parts of Os Draconis.

5. like the arbitrary described application of claim 1-4, it is characterized in that the active component of this Chinese medicine composition is processed by the following step:

A) people participates in 70% alcohol reflux three times, and merge extractive liquid, filters, and concentrates, and oven dry is ground into fine powder;

B) Fructus Schisandrae Sphenantherae, Fructus Corni, Radix Salviae Miltiorrhizae, Rhizoma Coptidis, Radix Et Rhizoma Nardostachyos add 70% alcohol reflux 3 times jointly, and merge extractive liquid, filters, and is subsequent use;

C) Eupolyph aga sinesis Walker is broken into fine powder;

D) Radix Ophiopogonis, Semen Ziziphi Spinosae (parched), Herba Taxilli, Radix Paeoniae Rubra, Os Draconis decocte with water 2 times, merge extractive liquid, filters, and is subsequent use;

E) with step b) and d) merging of gained extracting solution, reclaim ethanol, be condensed into extractum, add the fine drug powder of step c) gained, oven dry is ground into fine powder, adds step a) gained fine drug powder, and mixing promptly gets this Chinese medicine composition active component.

6. like each described application among the claim 1-4, it is characterized in that the preparation formulation of said Chinese medicine composition is capsule, tablet, granule, powder or oral liquid.

7. application as claimed in claim 6 is characterized in that said capsule processed by following steps:

A) people participates in 8 times of amount 70% alcohol reflux three times, and 3 hours for the first time, each 2 hours later on, merge extractive liquid, filtered, and reclaims ethanol, concentrates, and oven dry is ground into 80 order fine powders;

B) Fructus Schisandrae Sphenantherae, Fructus Corni, Radix Salviae Miltiorrhizae, Rhizoma Coptidis, Radix Et Rhizoma Nardostachyos add 8 times of amount 70% alcohol reflux 3 times, and merge extractive liquid, filters, and reclaims ethanol;

C) TUBIECHONG is ground into 80 order fine powders;

D) Radix Ophiopogonis, Semen Ziziphi Spinosae (parched), Herba Taxilli, Radix Paeoniae Rubra, Os Draconis add 9 times of amount decoctions of water 2 times, and merge extractive liquid, filters; Merge with the extracting solution of step b) gained, be condensed into extractum, add step c) gained fine powder; Oven dry is ground into 80 order fine powders, adds step a) gained fine powder; Mixing encapsulatedly promptly gets.