CN104173766A - Traditional Chinese medicine composition for treating hypertension and preparation method of traditional Chinese medicine composition - Google Patents
Traditional Chinese medicine composition for treating hypertension and preparation method of traditional Chinese medicine composition Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine composition for treating hypertension and a preparation method of the traditional Chinese medicine composition. The traditional Chinese medicine composition is prepared from the following various raw material medicines in parts by weight: 8-15 parts of chrysanthemum, 6-9 parts of gastrodia elata, 7-19 parts of uncaria, 7-13 parts of fried Eucommia ulmoides, 7-14 parts of the root of red-rooted salvia, 10-15 parts of white paeony root, 8-13 parts of semen cassiae and 8-15 parts of elecampane. The traditional Chinese medicine composition is prepared through compatibility of medicines according to the mutual promotion and mutual-assistance principle in the traditional Chinese medicine theory, achieves the effects of promoting blood circulation to remove blood stasis, softening blood vessels, suppressing hyperactive liver for calming endogenous wind and regulating yin and yang, is used for treating hypertension symptoms such as headache, dizziness, tinnitus and soreness and weakness of waist and knees caused by Qi-stagnation and blood stasis, has an obvious curative effect on the hypertension, is good in blood pressure reduction effect and short in course of treatment and does not have any toxic or side effect, and the hypertension has small possibility of recurrence after drug withdrawal.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition, relate in particular to a kind of Chinese medicine composition for the treatment of the high-risk symptom of hypertension, the invention still further relates to the preparation method of this Chinese medicine composition, belong to the field of Chinese medicines.
Background technology
Hypertension is one of common chronic disease of internal medicine, and the crowd of any age bracket all can fall ill, and has brought great impact to people's Health and Living.Hypertension refers to that under quiescent condition systolic arterial pressure and/or diastolic pressure increase (>=140/90mmHg), often with organ dysfunction or organic changes such as fat and sugar metabolism disorder and the heart, brain, kidney and retinas, the organ of take reinvent as the systemic disease hypertension of feature be common cardiovascular disease, the systemic arterial blood pressure persistence of take increases the clinical syndrome as main manifestations.Hypertension is that the pressure anomaly in arteries raises, arteries is as the pipeline of flowing water, if the effectively blood pressure lowering not in time of long-term hypertension, heart will have plump expansion because of overworked compensatory, and then there is nonfunction, hypertensive heart disease that Here it is, heart failure; Equally, kidney is profuse capillary network, and this fine pipeline issues stiffization, narrow, functional lesion in the impact of long-term high pressure, thereby makes the function of poisonous substance in capillary of kidney net eliminating health impaired, in body, noxious substance stores in blood, becomes renal failure, uremia.
Hypertensive western medical treatment is a long-term process, but in blood pressure lowering Western medicine used, much all there is side effect, because it is generally by blood vessel dilating by force, increase the means such as cardiac contractile force and carry out blood pressure lowering, though its pressure decay rate is fast, but cure the symptoms, not the disease, not only cannot suppress that sb.'s illness took a turn for the worse and blocking-up complication, can aggravate the generation of complication on the contrary, because taking a large amount of drug metabolism toxin producing after depressor can be deposited in blood vessel wall, take the also just more of more depositions, finally can cause sclerosis of blood vessels, attenuation, become fragile.Long-term taking western medicine of depressurization will become catalyst, the accomplice of the alleged hypertension complication of medical expert.
Summary of the invention
The object of this invention is to provide a kind ofly to hypertension definite curative effect, the Chinese medicine composition having no side effect again, the invention provides the preparation method of this Chinese medicine composition simultaneously.
The object of the invention is to realize by following technical solution:
Treat a Chinese medicine composition for the high-risk disease of hypertension, described Chinese medicine composition is made by each crude drug of following weight portion: Flos Chrysanthemi 8-15 part, Rhizoma Gastrodiae 6-9 part, Ramulus Uncariae Cum Uncis 7-19 part, Cortex Eucommiae (parched) 7-13 part, Radix Salviae Miltiorrhizae 7-14 part, Radix Paeoniae Alba 10-15 part, Semen Cassiae 8-13 part, Radix Aucklandiae 8-15 part.
Preferably, described Chinese medicine composition is made by each crude drug of following weight portion: 12 parts of Flos Chrysanthemis, 7 parts, Rhizoma Gastrodiae, 13 parts of Ramulus Uncariae Cum Uncis, 10 parts of Cortex Eucommiae (parched), 11 parts of Radix Salviae Miltiorrhizaes, 12 parts of the Radix Paeoniae Albas, 11 parts of Semen Cassiaes, 12 parts of the Radix Aucklandiae.
Chinese medicine composition of the present invention is according to traditional Chinese medical science strengthening vital QI to eliminate pathogenic factors, the theory for the treatment of both the principal and secondary aspects of a disease, and simultaneously according to inventor's clinical experience and pharmaceutical research achievement for many years, screening crude drug, according to certain weight proportion prescription, meticulously develop.
The traditional Chinese medical science thinks that hypertension belongs to congestion, congestion hinder in the heart or on combine in head, congestion is stagnated loose, be deficiency of the liver and kindey, liver-yang is partially high, intimately due to liver-wind pathogen upward attacking orifices in head, clinical symptoms is a lot of, wherein with headache, dizziness is the most common, all YANG-meridians meeting into the head, house of intelligence, the blood of the five internal organs elite, no matter therefore Exogenous and internal injuries all can be violated top, top, and cause dizziness.Therefore, inventor thinks conditioning viscera function, recovers equilibrium between yin and yang and is only and effects a permanent cure, therefore adopt blood circulation promoting and blood stasis dispelling for treatment rule forms Chinese medicine composition of the present invention, has the effect with QI and blood, regulate yin-yang, blood pressure lowering.
Side's ZHONGJUHUA sweetness and bitterness, cool, enter lung, spleen; Liver, kidney four warps, have dispelling wind, heat clearing away, and improving eyesight, the effect of removing toxic substances, cures mainly headache, dizzy, conjunctival congestion, irritable feverish sensation of chest and heart, furuncle and toxic swelling.Rhizoma Gastrodiae, is rich in gastrodine, gastrodia elata polysaccharide, vitamin A, glycoside, alkaloid, vanillyl alcohol, vanillin, succinic acid, cupreol, lymphatic temperament etc., nontoxic; sweet in the mouth, flat, cure mainly and control dizzy pupil; wind syndrome of head headache, numb limbs and tense tendons, hemiplegia; aphasia; there is wind-damp dispelling, the effect of pain relieving, promoting flow of QI and blood, its clothes of a specified duration can suppressing the hyperactive liver QI invigorating, sharp waist knee joint, bone and muscle strengthening; also can increase periphery and coronary artery blood flow, heart is had to protective effect.Ramulus Uncariae Cum Uncis, sweet in the mouth cold in nature. effect is heat clearing away suppressing the hyperactive liver, and spasmolytic relieves dizziness, high fever, infantile convulsions, epilepsy, etc. because of containing Ramulus Uncariae cum Uncis alkali and isorhynchophylline, therefore there is excited respiratory center, expand peripheral vessels, the effect reducing blood pressure.The Cortex Eucommiae, sweet, warm.Return liver, kidney channel, there is invigorating the liver and kidney, strong waist knee joint, bone and muscle strengthening, go the effect of having a dizzy spell; Immune system, hormonal system, central nervous system, blood circulation and urinary system are had to regulating action in various degree, the excited Pituitary Adrenal cortex system of Cortex Eucommiae energy, adrenal cortex reinforcing function; After Cortex Eucommiae parch, can destroy its colloid and be conducive to the stripping of effective ingredient, than raw with effective, therefore the present invention adopts Cortex Eucommiae (parched) in filling a prescription.Radix Salviae Miltiorrhizae, nature and flavor are bitter, are slightly cold.GUIXIN, Liver Channel.There is stasis-dispelling and pain-killing, blood circulation promoting and blood stasis dispelling, the effect of the relieving restlessness that clears away heart-fire.The Radix Paeoniae Alba; containing paeoniflorin, paeonol, paeoniflorin; benzoic acid approximately 1.07%, volatile oil, fatty oil, resin, tannin, sugar, starch, phlegmatic temperament, protein, cupreol and triterpenes etc.; modern medicine study shows; the Radix Paeoniae Alba has the effect of protecting well and taking good care of to human body cardiovascular and cerebrovascular vessel; there is coronary artery dilator, the effect reducing blood pressure.Semen Cassiae, bitter in the mouth, sweet and cool in nature, has the functions such as clearing away liver-fire, wind-damp dispelling, tonifying kidney and improving eyesight, mainly contains the compounds such as chrysophanol, emodin, has the effect that serum cholesterol raises and atheromatous plaque forms that suppresses.The Radix Aucklandiae, pungent acrid in the mouth; Bitter; Warm in nature; Cure mainly promoting the circulation of QI to relieve pain; Intestinal stasis relieving in tune, regulates the flow of vital energy soothing the liver, the spleen invigorating stagnant and blood pressure lowering that disappears.
Each taste raw material used in the present invention can be bought and obtain in pharmacy.
Active constituents of medicine of the present invention can add prepares the required various adjuvants of different dosage form, with conventional method of Chinese medicinal, be prepared into any acceptable pharmaceutical preparation clinically, such as being pill, powder, granule, capsule, tablet or drop pill etc.
Preferably, a kind of method of preparing the hypertensive pharmaceutical composition of above-mentioned treatment, comprises the steps:
1) by described weight proportion, take each crude drug; And Ramulus Uncariae Cum Uncis is become separately to bag;
2) Rhizoma Gastrodiae, Cortex Eucommiae (parched), Radix Salviae Miltiorrhizae, the Radix Aucklandiae, the Radix Paeoniae Alba, Flos Chrysanthemi, Semen Cassiae are dropped into successively in extraction pot and decocted with water twice, adding for the first time water is 8 times of amounts of decoction pieces, decocts 1.5 hours, within first 30 minutes, puts into Ramulus Uncariae Cum Uncis and continue to decoct having decocted, medicinal liquid filters, and takes out Ramulus Uncariae Cum Uncis bag; Adding for the second time water is 6 times of amounts of decoction pieces, decocts 1 hour, within first 30 minutes, puts into Ramulus Uncariae Cum Uncis and continue to decoct having decocted, and medicinal liquid filters with above-mentioned medicinal liquid and merges, and medicinal residues are discarded, and decocting temperature is 95～100 ℃;
3) in temperature, be 60-70 ℃, pressure is simmer down to clear paste under the condition of-0.06 ~-0.08Mpa;
4) add the adjuvant of preparations shaping, obtain.
Preferably, clear paste described in step 3) is the clear paste that heat survey is 1.30-1.35 for relative density under the condition of 55 ℃.
The present invention forms according to the principle compatibility of the tcm theory mutual reinforcement between mutual-assistance, jointly reach blood circulation promoting and blood stasis dispelling, vessel softening, suppressing the hyperactive liver to relieve the wind syndrome, the effect of adjusting negative and positive, be used for the treatment of the vascular hypertensions such as headache that qi depression to blood stasis causes, dizziness, tinnitus, soreness of the waist and knees, the present invention has significant curative effect to hypertension, and antihypertensive effect is good, short treating period, have no side effect, after drug withdrawal, be difficult for recurrence.
The usage of Chinese medicine composition of the present invention and consumption: dosage of the present invention depends on the factors such as concrete dosage form, patient's age, health status.As guidance: for pill, oral: each 8, every day 3 times.
The specific embodiment
Below in conjunction with embodiment, further describe the present invention.
The preparation of embodiment 1 granule
By following weight, take each raw material: 70 grams of independent packagings of Ramulus Uncariae Cum Uncis, 80 grams of Flos Chrysanthemis, 60 grams, Rhizoma Gastrodiae, 70 grams of Cortex Eucommiae (parched), 70 grams of Radix Salviae Miltiorrhizaes, 100 grams of the Radix Paeoniae Albas, 80 grams of Semen Cassiaes, 80 grams of the Radix Aucklandiae; Then Rhizoma Gastrodiae, Cortex Eucommiae (parched), Radix Salviae Miltiorrhizae, the Radix Aucklandiae, the Radix Paeoniae Alba, Flos Chrysanthemi, Semen Cassiae are dropped into successively in extraction pot and decocted with water twice, adding for the first time water is 8 times of amounts of decoction pieces, decocts 1.5 hours, has decocted and within first 30 minutes, has put into Ramulus Uncariae Cum Uncis continuation decoction, medicinal liquid filters, and takes out Ramulus Uncariae Cum Uncis bag; Adding for the second time water is 6 times of amounts of decoction pieces, decocts 1 hour, has decocted and within first 30 minutes, has put into Ramulus Uncariae Cum Uncis bag continuation decoction, and medicinal liquid filters with above-mentioned medicinal liquid and merges, and medicinal residues are discarded, and decoction temperature is 95 ℃; In temperature, be 60 ℃, pressure is-condition of 0.068Mpa under simmer down to clear paste, relative density is 1.30-1.35(55 ℃) clear paste, clear paste is placed in vacuum drying oven, control temperature and be dried under the condition of 80 ℃, dry extract was through pulverizing 80 eye mesh screens; Add 350 grams, dextrin, mix, add suitable amount of adhesive granulation, particle drying, reaches moisture requirement granulate, and subpackage, obtains.
The preparation of embodiment 2 capsules
By following weight, take each raw material: 130 grams of independent packagings of Ramulus Uncariae Cum Uncis, 120 grams of Flos Chrysanthemis, 70 grams, Rhizoma Gastrodiae,, 100 grams of Cortex Eucommiae (parched), 110 grams of Radix Salviae Miltiorrhizaes, 120 grams of the Radix Paeoniae Albas, 110 grams of Semen Cassiaes, 120 grams of the Radix Aucklandiae; Then Rhizoma Gastrodiae, Cortex Eucommiae (parched), Radix Salviae Miltiorrhizae, the Radix Aucklandiae, the Radix Paeoniae Alba, Flos Chrysanthemi, Semen Cassiae are dropped into successively in extraction pot and decocted with water twice, adding for the first time water is 8 times of amounts of decoction pieces, decocts 1.5 hours, has decocted and within first 30 minutes, has put into Ramulus Uncariae Cum Uncis bag continuation decoction, medicinal liquid filters, and takes out Ramulus Uncariae Cum Uncis bag; Adding for the second time water is 6 times of amounts of decoction pieces, decocts 1 hour, has decocted and within first 30 minutes, has put into Ramulus Uncariae Cum Uncis bag continuation decoction, and medicinal liquid filters with above-mentioned medicinal liquid and merges, and medicinal residues are discarded, and decoction temperature is 95 ℃; In temperature, be 60 ℃, pressure is-condition of 0.08Mpa under simmer down to clear paste, relative density is 1.30-1.35(55 ℃) clear paste, clear paste is placed in vacuum drying oven, control temperature and be dried under the condition of 80 ℃, dry extract was through pulverizing 80 eye mesh screens; Add 330 grams, dextrin, mix, add suitable amount of adhesive granulation, particle drying, reaches moisture requirement granulate, and the granule after granulate mixes 30 minutes through two-dimensional motion mixer, through capsule filling machine, load into powder, with Aluminium-coating Packer, powder is packed to patent medicine plate, medicine plate packing is made finished product.
The preparation of embodiment 3 tablets
By following weight, take each raw material: 190 grams of independent packagings of Ramulus Uncariae Cum Uncis, 150 grams of Flos Chrysanthemis, 90 grams, Rhizoma Gastrodiae, 130 grams of Cortex Eucommiae (parched), 140 grams of Radix Salviae Miltiorrhizaes, 150 grams of the Radix Paeoniae Albas, 130 grams of Semen Cassiaes, 150 grams of the Radix Aucklandiae; Then Rhizoma Gastrodiae, Cortex Eucommiae (parched), Radix Salviae Miltiorrhizae, the Radix Aucklandiae, the Radix Paeoniae Alba, Flos Chrysanthemi, Semen Cassiae are dropped into successively in extraction pot and decocted with water twice, adding for the first time water is 8 times of amounts of decoction pieces, decocts 1.5 hours, has decocted and within first 30 minutes, has put into Ramulus Uncariae Cum Uncis continuation decoction, medicinal liquid filters, and takes out Ramulus Uncariae Cum Uncis bag; Adding for the second time water is 6 times of amounts of decoction pieces, decocts 1 hour, has decocted and within first 30 minutes, has put into Ramulus Uncariae Cum Uncis bag continuation decoction, and medicinal liquid filters with above-mentioned medicinal liquid and merges, and medicinal residues are discarded, and decoction temperature is 100 ℃; In temperature, be 60 ℃, pressure is-condition of 0.08Mpa under simmer down to clear paste, relative density is 1.30-1.35(55 ℃) clear paste, clear paste is placed in vacuum drying oven, control temperature and be dried under the condition of 80 ℃, dry extract was through pulverizing 80 eye mesh screens; Add 450 grams, dextrin, add appropriate starch, magnesium stearate simultaneously, mix, tabletting, film coating, packing, obtains.
Experimental example 1 pharmaceutical composition preparation process condition of the present invention is optimized:
Because Ramulus Uncariae Cum Uncis contains alkaloid component, and alkaloid component has to hypertension the permanent antihypertensive effect of continuing, but its raw material Ramulus Uncariae Cum Uncis can not decoct for a long time, through test, find, decocting time is long, in decocting liquid, alkaloidal output does not rise counter falling, will affect its drug effect like this, therefore complete in order to ensure the extraction of alkaloid effective ingredient in the present invention, in experiment on affecting the alkaloidal principal element of Ramulus Uncariae Cum Uncis, it is solvent amount, extraction time and decoction number of times, the content of determining Ramulus Uncariae Cum Uncis generation biology total alkali by acid-base titrations is index, adopt orthogonal experiment, and carry out data analysis processing by the method for intuitive analysis method and variance analysis, to determine rational extraction conditions.
1. the design of orthogonal table
2. experimental technique and data
By L (3) orthogonal table, test, with the NaOH solution titration of 0.018mol/L, the milliliter number that the biology total alkali of take is equivalent to sodium hydroxide is evaluation index, and experiment Ramulus Uncariae Cum Uncis raw material is 20g,
3. the analysis of variance table of biology total alkali content
From above-mentioned experimental result, it is key factor that two factors of amount of water and decocting time all have significant difference, and it is less to decoct the difference of twice and three times, according to interpretation of result, determine and decoct twice, add for the first time 8 times of amounts of water, decoct 30 minutes, add for the second time 6 times of amounts of water, decoct and be advisable for 30 minutes.
Therefore, in the decoction process of raw material of the present invention in order to ensure the drug effect of Ramulus Uncariae Cum Uncis, Ramulus Uncariae Cum Uncis to be packed separately, in decoction for the first time, before finishing, within 30 minutes, add extraction pot, decocted for the first time rear taking-up, at before having decocted for the second time 30 minutes, put into again extraction pot and decoct to completing together with other raw materials.
The toxicology test of experimental example 2 pharmaceutical compositions of the present invention
1. acute toxicity test: choose body weight and be 40 of the mices of 20-22.5 gram, be divided into 4 groups, 10 every group; Each is organized dose and arranges by geometric progression, and single administration is observed 3 days, and duration of test records dead mouse number, female, male mice: be (LD50) 79g/kgBW, illustrate that product of the present invention belongs to nontoxic level;
2. genetic toxicity test (Salmonella reversion test, bone marrow cell micronucleus test, mouse sperm deformity test): result of the test is all negative, has no Genotoxic Effect;
3. the rat feeding trial of 30 days: choosing body weight is 30 of 35-38 gram of rats, male and female are regardless of, be divided into 3 groups, every group 10, wherein two groups of dosages are respectively 0.3 gram and 0.6 gram, do not give any medicine for other one group, during administration, the indices such as routine blood test, blood biochemistry index, organ coefficient and body weight, weightening finish, food-intake, food use are detected, be showed no harmful effect; After 30 days, histopathology is observed, liver,spleen,kidney, Stomach duodenum, testis, ovary are showed no significant pathological change.In this test, the consumption of rat every day is about 100 times of left and right of per day for adults consumption, and the pathologic finding of above administration to main organs official, is showed no harmful effect, and this medicine quantity is safe thus.
Experimental example 3 utilizes the present invention to treat hypertensive clinical effectiveness
1. physical data: all observe case and amount to 765 examples, the traditional Chinese medical science clinic patient who all comes from JIUYUE, 1996 to 2011 Nian Sanjia Dalian hospital, all meet in < < Chinese hypertension prevention and control guide > > in 2004 about hypertensive diagnostic criteria, male 416 examples wherein, female's 349 examples, the range of age is in 18-70 year, and the mean age is 44 years old.
2. Therapeutic Method: the capsule of embodiment 2 of take is example, the oral medicine of this medicine: everyone every day twice, each 8; Be 1 month the course for the treatment of.Period in a medicine is prohibited pungent thing, the careful clothes of anemia of pregnant woman.
3. clinical therapeutic efficacy: according to the observation of 765 cases, most of patients after taking medicine (695 example) blood pressure all has decline in various degree, (457 example) having can be down to normal or be approached normal range, and these are hypertension early stage patient substantially.Along with the decline of blood pressure, subjective symptoms is also corresponding alleviates or disappear for dizzy, headache, nervous, tachypnea, insomnia etc.According to case observation, after blood pressure drops starts from taking medicine 2～7 days, antihypertensive effect was very remarkable after 10 days.The curve of blood pressure drops is ramped shaped, show this product action temperature and.Indivedual cases have rise phenomenon at period in a medicine, but the amplitude of fluctuation is very little, and without severity of symptoms.Stadium more early curative effect better, for the first phase second phase, patient has certain curative effect, and belong to third phase patient antihypertensive effect, is not remarkable especially, though these patient's blood pressures without significant change, and symptom has clear improvement.No side effects in treatment.The invention belongs to the Chinese medicine of durative action preparation, have no side effect and dependency, there is desirable rehabilitation effect, the symptoms such as the headache causing because of hypertension, dizzy, tinnitus and pain in the low back and legs are had to good alleviation effect.
The above; it is only the preferably specific embodiment of the present invention; but protection scope of the present invention is not limited to this; anyly be familiar with those skilled in the art in the technical scope that the present invention discloses; according to technical scheme of the present invention and inventive concept thereof, be equal to replacement or changed, within all should being encompassed in protection scope of the present invention.
Claims (6)
1. a Chinese medicine composition for the treatment of the high-risk disease of hypertension, it is characterized in that, described Chinese medicine composition is made by each crude drug of following weight portion: Flos Chrysanthemi 8-15 part, Rhizoma Gastrodiae 6-9 part, Ramulus Uncariae Cum Uncis 7-19 part, Cortex Eucommiae (parched) 7-13 part, Radix Salviae Miltiorrhizae 7-14 part, Radix Paeoniae Alba 10-15 part, Semen Cassiae 8-13 part, Radix Aucklandiae 8-15 part.
2. a kind of Chinese medicine composition for the treatment of the high-risk disease of hypertension according to claim 1, it is characterized in that, described Chinese medicine composition is made by each crude drug of following weight portion: 12 parts of Flos Chrysanthemis, 7 parts, Rhizoma Gastrodiae, 13 parts of Ramulus Uncariae Cum Uncis, 10 parts of Cortex Eucommiae (parched), 11 parts of Radix Salviae Miltiorrhizaes, 12 parts of the Radix Paeoniae Albas, 11 parts of Semen Cassiaes, 12 parts of the Radix Aucklandiae.
3. Chinese medicine composition according to claim 1 and 2, is characterized in that, described Chinese medicine composition is prepared into any acceptable pharmaceutical preparation clinically according to Chinese medicine conventional formulation method.
4. a method of preparing the Chinese medicine composition described in claim 1 or 2, is characterized in that, comprises the steps:
1) by described weight proportion, take each crude drug, and Ramulus Uncariae Cum Uncis is become separately to bag;
2) Rhizoma Gastrodiae, Cortex Eucommiae (parched), Radix Salviae Miltiorrhizae, the Radix Aucklandiae, the Radix Paeoniae Alba, Flos Chrysanthemi, Semen Cassiae are dropped into successively in extraction pot and decocted with water twice, adding for the first time water is 8 times of amounts of decoction pieces, decocts 1.5 hours, within first 30 minutes, puts into Ramulus Uncariae Cum Uncis and continue to decoct having decocted, medicinal liquid filters, and takes out Ramulus Uncariae Cum Uncis bag; Adding for the second time water is 6 times of amounts of decoction pieces, decocts 1 hour, within first 30 minutes, puts into Ramulus Uncariae Cum Uncis and continue to decoct having decocted, and medicinal liquid filters with above-mentioned medicinal liquid and merges, and medicinal residues are discarded, and decocting temperature is 95～100 ℃;
3) in temperature, be 60-70 ℃, pressure is simmer down to clear paste under the condition of-0.06 ~-0.08Mpa;
4) add the adjuvant of preparations shaping, obtain.
5. method according to claim 4, is characterized in that, clear paste described in step 3) is the clear paste that heat survey is 1.30-1.35 for relative density under the condition of 55 ℃.
6. the application of the Chinese medicine composition described in claim 1 or 2 in the high-risk symptom medicine for the treatment of hypertension.
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| CN103417850A (en) * | 2012-05-16 | 2013-12-04 | 何宗清 | Oral medicine for treating hypertensive disease in Chinese medical science manner |
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| CN105770496A (en) * | 2016-04-08 | 2016-07-20 | 烟台市蓝洋之草医药生物科技有限公司 | Pharmaceutical composition for treating high blood pressure |
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Application publication date: 20141203 |