CN104398971A - Traditional Chinese medicine composition for treating liver cirrhosis, and preparation method and application thereof - Google Patents

Traditional Chinese medicine composition for treating liver cirrhosis, and preparation method and application thereof Download PDF

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CN104398971A
CN104398971A CN201410611920.7A CN201410611920A CN104398971A CN 104398971 A CN104398971 A CN 104398971A CN 201410611920 A CN201410611920 A CN 201410611920A CN 104398971 A CN104398971 A CN 104398971A
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王松华
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    • A—HUMAN NECESSITIES
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    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
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    • A61K35/586—Turtles; Tortoises, e.g. terrapins
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/07—Basidiomycota, e.g. Cryptococcus
    • A61K36/076—Poria
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Abstract

The invention relates to the field of traditional Chinese medicine preparations, and especially relates to a traditional Chinese medicine composition for treating liver cirrhosis, and a preparation method and application thereof. The bulk drugs of the compositions comprise 1-8 parts by weight of carapax trionycis, 2-10 parts by weight of semen persicae, 4-12 parts by weight of radix salviae miltiorrhizae, 6-15 parts by weight of radix curcumae, 8-16 parts by weight of rhizoma atractylodis macrocephalae, 1-8 parts by weight of ginseng, 2-10 parts by weight of ground beetle, 1-8 parts by weight of rhizoma cimicifugae, 2-10 parts by weight of common goldenrod herb, 1-8 parts by weight of rhizoma paridis chinensis, 2-10 parts by weight of radix isatidis, 1-6 parts by weight of panax notoginseng, 2-10 parts by weight of rhizoma cyperi, 2-10 parts by weight of spreading hedyotis herb, 4-12 parts by weight of poria, and 1-10 parts by weight of indigo naturalis. The traditional Chinese medicine composition has good curative effect on liver cirrhosis disease, and is high in cure rate and low in recurrence rate.

Description

A kind of Chinese medicine composition being used for the treatment of liver cirrhosis and preparation method thereof and application
Technical field
The present invention relates to field of traditional Chinese, particularly a kind of Chinese medicine composition being used for the treatment of liver cirrhosis and preparation method thereof and application.
Background technology
Liver cirrhosis (hepatic cirrhosis) is clinical chronic progressive external hepatopathy the most common, the diffusivity hepatic injury that long-term or repeated action is formed by one or more causes of disease.Histopathology there are hepatic necrosis, the regeneration of remaining liver cell nodules, connective tissue proliferation and fiber widely every formation, cause lobules of liver structural deterioration and pseudolobuli formation, liver is out of shape gradually, hardening and develop into liver cirrhosis.Cause the cause of disease of liver cirrhosis a lot, viral hepatitis liver cirrhosis, alcoholic cirrhosis, metabolic liver cirrhosis, Cholestatic cirrhosis, hepatic vein backflow obstruction liver cirrhosis, autoimmune cirrhosis, poisonous substance and drug induced liver cirrhosis, nutritional cirrhosis, cryptogenic cirrhosis etc. can be divided into.
In China, Most patients is posthepatitic cirrhosis, and small part is alcoholic cirrhosis and Cirrhosis In Schistosomiasis.In early days due to the comparatively strong general non-evident sympton of liver compensation, stage with liver function injury and portal hypertension for main manifestations, and have multisystem to get involved, often there is the complication such as upper gastrointestinal hemorrhage, hepatic encephalopathy, secondary infection, hypersplenism, ascites, canceration late period.Liver cirrhosis is often dead because leading to complications, and upper gastrointestinal hemorrhage is the modal complication of liver cirrhosis, and the hepatic encephalopathy modal cause of death that is liver cirrhosis.Hepatic encephalopathy, infection hepatitis, primary hepatocarcinoma, hepatorenal syndrome, portal thrombosis, respiratory system damage, seroperitoneum are also its common complications.
Treatment at present for liver cirrhosis there is no specific drug, and due to the unsuitable Drug abuse of particularity of liver, otherwise will burden of liver be increased the weight of and run counter to desire.At present, the means of conventional treatment liver cirrhosis comprise daily supplementary various vitamin and take the hepatocellular medicine of protection etc.Improve hepatocyte metabolism because injection Vitamin B_6 and B vitamin have, prevent Steatosis and protect hepatocellular effect, can dailyly take for prevention, also can take yeast tablet and take the circumstances into consideration vitimin supplement K, B12 and folic acid reinforcement prevention effect.The hepatocellular medicine of common protection, as glucuronolatone, dissopropylamine ascorbate, proheparin, silybin (silymarin tablet), inosine etc.; Also can use in 10% Glucose Liquid and add vitamin C, B6, potassium chloride and soluble insulin auxiliary treatment.
The diagnosis and treatment of the traditional Chinese medical science to hepatopathy especially chronic hepatopathy have the opinion of its uniqueness, and have obtained good curative effect and progress.The traditional Chinese medical science thinks that liver cirrhosis is by caused by damp and hot, and irritability is smouldered affects taste, and cause hematogenous blockage, venation is blocked, cause and gather or disease purplish or white patches on the skin, ascites appears in stage.Dialectical many genus liver-stagnation spleen-deficiencies or water amass tympanites type, and the former can use Radix Bupleuri Shugan Decoction (faling apart), liver recovery decoction etc.; The latter can by WULING SAN or WUPI YIN.But, above-mentioned widely used existing preparation is all treat for general chronic hepatopathy, and for bupleurum powder for relieving liver-qi, it comes from " medical science system purport ", prescription is represented for depressed liver-energy dispersing and QI regulating, have dispersing the stagnated live-QI to relieve the stagnation of QI, promoting the circulation of QI to relieve pain, to effect, cure mainly irritability stasis card, as the pain over the hypochondriac region or alternate attack of chill and fever, belch is heaved a deep sigh, distension and fullness in the abdomen, stringy pulse etc.; The clinical treatment being usually used in hepatitis, chronic gastritis, cholecystitis, and the intercostal neuralgia etc. belongs to stagnation of QI due to depression of the liver person.Visible, above-mentioned routine is used for the treatment of the prescription of chronic hepatopathy, though extensively can treat common Chronic Liver disease, for the treatment of liver cirrhosis disease, then there is the problem that onset is slow, specific aim is poor.
Summary of the invention
Technical problem to be solved by this invention is to provide a kind of effectively can treat liver cirrhosis and the little Chinese medicine composition of short treating period, side effect.
The present invention still further provides preparation method and its application of above-mentioned Chinese medicine composition.
A kind of Chinese medicine composition being used for the treatment of liver cirrhosis provided by the invention, crude drug consists of: Carapax Trionycis 1-8 weight portion, Semen Persicae 2-10 weight portion, Radix Salviae Miltiorrhizae 4-12 weight portion, Radix Curcumae 6-15 weight portion, Rhizoma Atractylodis Macrocephalae 8-16 weight portion, Radix Ginseng 1-8 weight portion, Eupolyphaga Seu Steleophaga 2-10 weight portion, Rhizoma Cimicifugae 1-8 weight portion, Herba Solidaginis 2-10 weight portion, Rhizoma Paridis 1-8 measures part, Radix Isatidis 2-10 weight portion, Radix Notoginseng 1-6 weight portion, Rhizoma Cyperi 2-10 weight portion, Herba Hedyotidis Diffusae 2-10 weight portion, Poria 4-12 weight portion, Indigo Naturalis 1-10 weight portion.
Further, the described Chinese medicine composition being used for the treatment of liver cirrhosis, crude drug consists of: Carapax Trionycis 2-6 weight portion, Semen Persicae 4-8 weight portion, Radix Salviae Miltiorrhizae 6-10 weight portion, Radix Curcumae 8-12 weight portion, Rhizoma Atractylodis Macrocephalae 10-15 weight portion, Radix Ginseng 2-6 weight portion, Eupolyphaga Seu Steleophaga 4-8 weight portion, Rhizoma Cimicifugae 2-6 weight portion, Herba Solidaginis 4-8 weight portion, Rhizoma Paridis 2-6 weight portion, Radix Isatidis 4-8 weight portion, Radix Notoginseng 2-5 weight portion, Rhizoma Cyperi 4-8 weight portion, Herba Hedyotidis Diffusae 4-8 weight portion, Poria 10-12 weight portion, Indigo Naturalis 3-8 weight portion.
The described Chinese medicine composition being used for the treatment of liver cirrhosis, preferably, crude drug consists of: Carapax Trionycis 4 weight portion, Semen Persicae 6 weight portion, Radix Salviae Miltiorrhizae 8 weight portion, Radix Curcumae 10 weight portion, the Rhizoma Atractylodis Macrocephalae 12 weight portion, Radix Ginseng 4 weight portion, Eupolyphaga Seu Steleophaga 6 weight portion, Rhizoma Cimicifugae 4 weight portion, Herba Solidaginis 6 weight portion, Rhizoma Paridis 4 weight portion, Radix Isatidis 6 weight portion, Radix Notoginseng 3 weight portion, Rhizoma Cyperi 6 weight portion, Herba Hedyotidis Diffusae 6 weight portion, Poria 8 weight portion, Indigo Naturalis 5 weight portion.
The invention also discloses and add customary adjuvant by arbitrary described Chinese medicine composition selectivity being used for the treatment of liver cirrhosis, conveniently the acceptable clinically preparation made of technique.
Described preparation, comprises electuary, powder, tablet, granule, capsule, mixture, pill, injection or drop pill.
The invention also discloses a kind of method preparing arbitrary described Chinese medicine composition, get Carapax Trionycis, Semen Persicae, Radix Salviae Miltiorrhizae according to selected weight portion, Radix Curcumae, the Rhizoma Atractylodis Macrocephalae, Radix Ginseng, Eupolyphaga Seu Steleophaga, Rhizoma Cimicifugae, Herba Solidaginis, Rhizoma Paridis, Radix Isatidis, Radix Notoginseng, Rhizoma Cyperi, Herba Hedyotidis Diffusae, Poria and Indigo Naturalis, selectivity adds customary adjuvant, conveniently technique, makes acceptable preparation clinically.
Further, described preparation method, comprises the steps:
Carapax Trionycis is got, Semen Persicae, Radix Salviae Miltiorrhizae, Radix Curcumae according to selected parts by weight, the Rhizoma Atractylodis Macrocephalae, Radix Ginseng, Eupolyphaga Seu Steleophaga, Rhizoma Cimicifugae, Herba Solidaginis, Rhizoma Paridis, Radix Isatidis, Radix Notoginseng, Rhizoma Cyperi, Herba Hedyotidis Diffusae, Poria and Indigo Naturalis, remix after pulverizing or pulverizing respectively, sieve after mixing, and selectivity adds customary adjuvant, conveniently technique, makes acceptable preparation clinically.
Further, described preparation method, comprises the steps:
Carapax Trionycis is got, Semen Persicae, Radix Salviae Miltiorrhizae, Radix Curcumae, the Rhizoma Atractylodis Macrocephalae, Radix Ginseng, Eupolyphaga Seu Steleophaga according to selected parts by weight, Rhizoma Cimicifugae, Herba Solidaginis, Rhizoma Paridis, Radix Isatidis, Radix Notoginseng, Rhizoma Cyperi, Herba Hedyotidis Diffusae, Poria and Indigo Naturalis, mixing, extracting in water, filters and collects filtrate, obtaining concentrated solution after concentrating under reduced pressure; Above-mentioned concentrated solution selectivity is added customary adjuvant, conveniently technique, make clinical acceptable preparation; Or
Carapax Trionycis is got, Semen Persicae, Radix Salviae Miltiorrhizae, Radix Curcumae, the Rhizoma Atractylodis Macrocephalae, Radix Ginseng, Eupolyphaga Seu Steleophaga according to selected parts by weight, Rhizoma Cimicifugae, Herba Solidaginis, Rhizoma Paridis, Radix Isatidis, Radix Notoginseng, Rhizoma Cyperi, Herba Hedyotidis Diffusae, Poria and Indigo Naturalis, mixing, adds ethanol extraction, filters and collect filtrate, obtaining concentrated solution after concentrating under reduced pressure; Above-mentioned concentrated solution selectivity is added customary adjuvant, conveniently technique, make clinical acceptable preparation.
Preferably, described preparation method, is characterized in that, comprises the steps:
(1) get wherein one or more raw material components mixing according to selected parts by weight, add alcohol reflux, filter and collect filtrate, decompression recycling ethanol, to without alcohol taste, obtains alcohol extract;
(2) again according to raw material components mixing under selected parts by weight remainder, direct extracting in water, or mix extracting in water again with the medicinal residues after alcohol extraction in step (1), filter and collect filtrate, obtaining aqueous extract;
(3) merged by the aqueous extract obtained in the alcohol extract obtained in step (1) and step (2) and collect, concentrating under reduced pressure, obtains concentrated solution;
(4) above-mentioned concentrated solution selectivity is added customary adjuvant, conveniently technique, make clinical acceptable preparation.
The invention also discloses the Chinese medicine composition that prepared by arbitrary described Chinese medicine composition or arbitrary described method for the preparation of the purposes in treatment liver cirrhosis medicine.
In Chinese medicine composition of the present invention: Carapax Trionycis: return liver, kidney channel, there is the hypertrophy suppressing connective tissue, the effect improving plasma protein, mass dissipating and swelling eliminating, antineoplastic immunocompetence can be improved.Semen Persicae: can increase femoral artery blood flow and reduce vascular resistance, having direct dilating effect to blood vessel wall, these product also have suppression blood coagulation and haemolysis; Liver surface microcirculation is had some improvement; The glycerol trioleate be separated from Semen Persicae has anticoagulant active, the effect such as anticoagulation, antithrombotic, prevention hepatic fibrosis of Semen Persicae, the protective action good to liver peroxide injury tool.Radix Salviae Miltiorrhizae: nature and flavor are bitter, be slightly cold, GUIXIN, Liver Channel; Have stasis-dispelling and pain-killing, promoting blood circulation to restore menstrual flow, the effect of the relieving restlessness that clears away heart-fire, root is used as medicine, and containing TANSHINONES, is robustness emmenagogue, has blood stasis dispelling, tissue regeneration promoting, invigorates blood circulation, the effectiveness such as regulating menstruation, has good result to acute, chronic hepatitis.Radix Curcumae: acrid in the mouth, hardship, cold in nature, return liver, the heart, lung meridian, have the use of regulating qi to disperse stagnation, heart fire-clearing upset-relieving, promoting the function of the gallbladder to alleviate jaundice, promoting blood circulation and stopping pain, promoting QI circulation for relieving depression, the removing heat from blood that clears away heart-fire, the how raw use of the general disease of Radix Curcumae, waking up the patient from unconsciousness by dissipating phlegm Yi Fanshui fries.The Rhizoma Atractylodis Macrocephalae: bitter in the mouth, sweet, warm in nature, return spleen, stomach warp, invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis, antiabortive, for insufficiency of the spleen lack of appetite, abdominal distention is had loose bowels, phlegm retention vertigo and palpitation, edema, spontaneous perspiration, can available protecting liver, the liver glycogen minimizing effect preventing carbon tetrachloride from causing.Radix Ginseng: sweet in the mouth, micro-hardship, warm in nature, flat, return spleen, lung meridian, heart channel, QI invigorating, Gu de-, promote the production of body fluid, calm the nerves, Fructus Alpiniae Oxyphyllae; For acute infectious hepatitis, under certain treatment condition, taking Radix Ginseng seemingly has certain positive effect for preventing changing chronic hepatitis into.Eupolyphaga Seu Steleophaga: have certain inhibitory action to experimental animal tumor, Vitro Experimental Results shows, Eupolyphaga Seu Steleophaga can suppress the breathing of hepatocarcinoma, stomach cancer cell.Rhizoma Cimicifugae: enter liver, lung two warp, ascending spleen-QI, the liver and the kidney tonifying, yang invigorating, delivers, rash, removing toxic substances, can control acute and chronic hepatitis B.Herba Solidaginis: yellow skin gas delicate fragrance, property is put down, mildly bitter flavor, flat, enters liver, gallbladder two warp, has the effect of anti-tumor activity.Rhizoma Paridis: bitter in the mouth, cool in nature, mild toxicity, GUIXIN, through, Liver Channel, has effect of anticancer, the reducing swelling and alleviating pain of relieving internal heat, heat clearing away arresting convulsion, antitussive and antiasthmatic.Radix Isatidis: bitter in the mouth is cold in nature, GUIXIN, stomach, liver, gallbladder meridian, function heat-clearing and toxic substances removing, removing heat from blood sore-throat relieving, cures mainly the disease caused by warm poison, as hepatitis, influenza, upper respiratory tract infection, epidemic encephalitis, parotitis, acute enteritis, bacillary dysentery, facial erysipelas, calentura send out speckle etc.Radix Notoginseng: sweet micro-hardship, temperature, can increase the blood flow of the outer internal organs of liver, improve liver microcirculation function; Promote the recovery that blood-liver exchanges to improve hepatocellular removing toxic substances, functions of expelling toxin simultaneously; Dense, sticky, poly-, the solidifying state of blood can be eliminated, improve liver circulation; Obvious therapeutical effect is had to immunologic liver injury; Liver Collagen can also be suppressed to synthesize, and promote the degraded of Liver Collagen and suppress the hypertrophy of fibroblast and sternzellen under central veins of liver, reduce the formation of collagen fiber, thus delay the process stoping hepatic fibrosis, and its degraded can be promoted to established fibrosis and absorb, and there is the effect of anti-hepatic fibrosis.Rhizoma Cyperi: pungent micro-hardship is sweet, flat, enter lung meridian, Liver Channel, spleen channel, stomach warp, resolving depression of regulating the flow of vital energy, for stagnation of QI due to depression of the liver, incoordination between the liver and stomach, chronic hepatitis, breast, the side of body, abdominal distention, dyspepsia, breast gastral cavity painful abdominal mass is vexed, and colic of cold type is suffered from abdominal pain.Herba Hedyotidis Diffusae: its patent medicine bitter in the mouth, light, cold in nature, is good at the multiple cancerous protuberance for the treatment of, can strengthens phagocyte vigor, effectively remove the hepatocyte encroached on by hepatitis B virus, and the hepatitis B virus at other position of body is also embedded by phagocyte.Poria: sweet in the mouth, light, property are put down, and be used as medicine and have the function of promoting diuresis to eliminate damp pathogen, strengthening the spleen stomach function regulating, mind tranquilizing and the heart calming, Poria energy enhancing human body immunity function, pachyman has obvious antitumor and protects the liver dirty effect.Indigo Naturalis: nature and flavor are salty-cold, enters Liver Channel, can enter again lung, stomach warp, have heat-clearing and toxic substances removing, blood cooling and ecchymoses removing, purging liver-fire, effect of arresting convulsion.
Pharmaceutical composition of the present invention is used as medicine with Carapax Trionycis, Semen Persicae, Radix Salviae Miltiorrhizae, Radix Curcumae, the Rhizoma Atractylodis Macrocephalae, Radix Ginseng, Eupolyphaga Seu Steleophaga, Rhizoma Cimicifugae, Herba Solidaginis, Rhizoma Paridis, Radix Isatidis, Radix Notoginseng, Rhizoma Cyperi, Herba Hedyotidis Diffusae, Poria and Indigo Naturalis, its promoting blood circulation to restore menstrual flow of row, regulating qi to disperse stagnation, removing toxic substances are to effect, there is the effect improving body immunity simultaneously, by the effective cooperation between monarch, have good curative effect to treatment liver cirrhosis, clinical cure rate is up to 97%.
Detailed description of the invention
Embodiment 1
The crude drug being used for the treatment of the Chinese medicine composition of liver cirrhosis of the present embodiment consists of: Carapax Trionycis 4g, Semen Persicae 6g, Radix Salviae Miltiorrhizae 8g, Radix Curcumae 10g, Rhizoma Atractylodis Macrocephalae 12g, Radix Ginseng 4g, Eupolyphaga Seu Steleophaga 6g, Rhizoma Cimicifugae 4g, Herba Solidaginis 6g, Rhizoma Paridis 4g, Radix Isatidis 6g, Radix Notoginseng 3g, Rhizoma Cyperi 6g, Herba Hedyotidis Diffusae 6g, Poria 8g, Indigo Naturalis 5g.
Get above-mentioned raw materials medicine component according to selected weight portion, add customary adjuvant, conveniently technique, make pill.Specifically comprise:
Carapax Trionycis is got, Semen Persicae, Radix Salviae Miltiorrhizae, Radix Curcumae according to selected parts by weight, the Rhizoma Atractylodis Macrocephalae, Radix Ginseng, Eupolyphaga Seu Steleophaga, Rhizoma Cimicifugae, Herba Solidaginis, Rhizoma Paridis, Radix Isatidis, Radix Notoginseng, Rhizoma Cyperi, Herba Hedyotidis Diffusae, Poria and Indigo Naturalis, pulverize respectively, cross 100 mesh sieves, mixing, adds appropriate water according to every 100g powder refined honey 20 ~ 50g, pill, dry, make water-honeyed pill; Or add refined honey 80 ~ 110g and make small honey pill or big honeyed pills, to obtain final product.
Embodiment 2
The crude drug being used for the treatment of the Chinese medicine composition of liver cirrhosis of the present embodiment consists of: Carapax Trionycis 1g, Semen Persicae 2g, Radix Salviae Miltiorrhizae 4g, Radix Curcumae 6g, Rhizoma Atractylodis Macrocephalae 8g, Radix Ginseng 1g, Eupolyphaga Seu Steleophaga 2g, Rhizoma Cimicifugae 1g, Herba Solidaginis 2g, Rhizoma Paridis 1g, Radix Isatidis 2g, Radix Notoginseng 1g, Rhizoma Cyperi 2g, Herba Hedyotidis Diffusae 2g, Poria 4g, Indigo Naturalis 1g.
Get above-mentioned raw materials medicine component according to selected weight portion, add customary adjuvant, conveniently technique, make tablet.Specifically comprise:
(1) Carapax Trionycis is got, Semen Persicae, Radix Salviae Miltiorrhizae, Radix Curcumae according to selected parts by weight, the Rhizoma Atractylodis Macrocephalae, Radix Ginseng, Eupolyphaga Seu Steleophaga, Rhizoma Cimicifugae, Herba Solidaginis, Rhizoma Paridis, Radix Isatidis, Radix Notoginseng, Rhizoma Cyperi, Herba Hedyotidis Diffusae, Poria and Indigo Naturalis, mixing, by the water reflux, extract, of 10 volume times amount, reflux, extract, 2 times under maintenance temperature 60 C, each 3h, filters and collects filtrate, obtaining aqueous extract;
(2) aqueous extract obtained in step (1) being evaporated to relative density is 1.05-1.30 (40 ~ 60 DEG C), obtains concentrated solution;
(3) by above-mentioned concentrated solution vacuum drying, pulverize, sieve, obtain dry extract, add customary adjuvant, conveniently technique, make tablet.
Embodiment 3
The crude drug being used for the treatment of the Chinese medicine composition of liver cirrhosis of the present embodiment consists of: Carapax Trionycis 2g, Semen Persicae 4g, Radix Salviae Miltiorrhizae 6g, Radix Curcumae 8g, Rhizoma Atractylodis Macrocephalae 10g, Radix Ginseng 2g, Eupolyphaga Seu Steleophaga 4g, Rhizoma Cimicifugae 2g, Herba Solidaginis 4g, Rhizoma Paridis 2g, Radix Isatidis 4g, Radix Notoginseng 2g, Rhizoma Cyperi 4g, Herba Hedyotidis Diffusae 4g, Poria 10g, Indigo Naturalis 3g.
Get above-mentioned raw materials medicine component according to selected weight portion, add customary adjuvant, conveniently technique, make powder.Specifically comprise:
(1) Carapax Trionycis is got, Semen Persicae, Radix Salviae Miltiorrhizae, Radix Curcumae according to selected parts by weight, the Rhizoma Atractylodis Macrocephalae, Radix Ginseng, Eupolyphaga Seu Steleophaga, Rhizoma Cimicifugae, Herba Solidaginis, Rhizoma Paridis, Radix Isatidis, Radix Notoginseng, Rhizoma Cyperi, Herba Hedyotidis Diffusae, Poria and Indigo Naturalis, mixing, with 75% alcohol reflux of 8 volume times amount, reflux, extract, 3 times at maintenance temperature 80 DEG C, each 1.5h, filter and collect filtrate, decompression recycling ethanol, to without alcohol taste, obtains alcohol extract;
(2) the alcohol extract concentrating under reduced pressure will obtained in step (1), obtains concentrated solution;
(3) be 1.05-1.30 (40 ~ 60 DEG C) by above-mentioned concentrated solution vacuum drying relative density, pulverize, sieve, obtain dry extract, add customary adjuvant, conveniently technique, make powder.
Embodiment 4
The crude drug being used for the treatment of the Chinese medicine composition of liver cirrhosis of the present embodiment consists of: Carapax Trionycis 6g, Semen Persicae 8g, Radix Salviae Miltiorrhizae 10g, Radix Curcumae 12g, Rhizoma Atractylodis Macrocephalae 15g, Radix Ginseng 6g, Eupolyphaga Seu Steleophaga 8g, Rhizoma Cimicifugae 6g, Herba Solidaginis 8g, Rhizoma Paridis 6g, Radix Isatidis 8g, Radix Notoginseng 5g, Rhizoma Cyperi 8g, Herba Hedyotidis Diffusae 8g, Poria 12g, Indigo Naturalis 8g.
Get above-mentioned raw materials medicine component according to selected weight portion, add customary adjuvant, conveniently technique, make granule.Specifically comprise:
(1) Carapax Trionycis is got, Semen Persicae, Radix Salviae Miltiorrhizae, Radix Curcumae according to selected parts by weight, the Rhizoma Atractylodis Macrocephalae, Radix Ginseng, Eupolyphaga Seu Steleophaga, Rhizoma Cimicifugae, Herba Solidaginis, Rhizoma Paridis, Radix Isatidis, Radix Notoginseng, Rhizoma Cyperi, Herba Hedyotidis Diffusae, Poria and Indigo Naturalis, mixing, with 90% alcohol reflux of 4 volume times amount, reflux, extract, 3 times under maintenance temperature 70 C, each 1.5h, filter and collect filtrate, decompression recycling ethanol, to without alcohol taste, obtains alcohol extract;
(2) in the medicinal residues after the alcohol extraction in step (1), add the water extraction 2 times of 15 volume times amount again, each 2h, filters and collects filtrate, obtaining aqueous extract;
(3) merged by the aqueous extract obtained in the alcohol extract obtained in step (1) and step (2) and collect, 60 DEG C of concentrating under reduced pressure, obtain concentrated solution;
(4) fluidized bed granulation is carried out with the concentrated solution obtained in step (3), be that the dextrin of 30 ~ 75% is for fluidisation carrier to account for described concentrated solution mass ratio, with account for described concentrated solution mass ratio be 1 ~ 5% traditional binders granulate, control that its feed liquor flow velocity is 2.5ml/min, fluidized pressure is 0.2 ~ 0.5bar, atomizing pressure is 1.0 ~ 1.8bar, temperature 55 DEG C, granulate, and increase gradually along with particle in fluid bed, adjustment fluidized pressure and atomizing pressure, keep the fluidized state of material good, temperature of charge remains between 35 ~ 37 DEG C.After feed liquor terminates, continue fluidized drying 1 hour, obtain granule.
Embodiment 5
The crude drug being used for the treatment of the Chinese medicine composition of liver cirrhosis of the present embodiment consists of: Carapax Trionycis 8g, Semen Persicae 10g, Radix Salviae Miltiorrhizae 12g, Radix Curcumae 15g, Rhizoma Atractylodis Macrocephalae 16g, Radix Ginseng 8g, Eupolyphaga Seu Steleophaga 10g, Rhizoma Cimicifugae 8g, Herba Solidaginis 10g, Rhizoma Paridis 8g, Radix Isatidis 10g, Radix Notoginseng 6g, Rhizoma Cyperi 10g, Herba Hedyotidis Diffusae 10g, Poria 12g, Indigo Naturalis 10g.
Get above-mentioned raw materials medicine component according to selected weight portion, add customary adjuvant, conveniently technique, make capsule.Specifically comprise:
(1) Carapax Trionycis is got, Semen Persicae, Radix Salviae Miltiorrhizae, Radix Curcumae according to selected parts by weight, the Rhizoma Atractylodis Macrocephalae, Radix Ginseng, Eupolyphaga Seu Steleophaga, Rhizoma Cimicifugae, Herba Solidaginis, Rhizoma Paridis, Radix Isatidis, Radix Notoginseng, Rhizoma Cyperi, Herba Hedyotidis Diffusae, Poria and Indigo Naturalis, mixing, with 50% alcohol reflux of 6 volume times amount, reflux, extract, 3 times at maintenance temperature 80 DEG C, each 2h, filter and collect filtrate, decompression recycling ethanol, to without alcohol taste, obtains alcohol extract;
(2) in the medicinal residues after the alcohol extraction in step (1), add the water extraction 1 time of 10 volume times amount again, 2h, filters and collects filtrate, obtaining aqueous extract;
(3) merged by the aqueous extract obtained in the alcohol extract obtained in step (1) and step (2) and collect, concentrating under reduced pressure, obtains concentrated solution;
(4) by above-mentioned concentrated solution vacuum drying, pulverize, sieve, obtain dry extract, directly encapsulated or encapsulated after adding customary adjuvant mix homogeneously, to obtain final product.
Embodiment 6
The crude drug being used for the treatment of the Chinese medicine composition of liver cirrhosis of the present embodiment consists of: Carapax Trionycis 1g, Semen Persicae 10g, Radix Salviae Miltiorrhizae 4g, Radix Curcumae 15g, Rhizoma Atractylodis Macrocephalae 8g, Radix Ginseng 8g, Eupolyphaga Seu Steleophaga 2g, Rhizoma Cimicifugae 8g, Herba Solidaginis 2g, Rhizoma Paridis 8g, Radix Isatidis 2g, Radix Notoginseng 6g, Rhizoma Cyperi 2g, Herba Hedyotidis Diffusae 10g, Poria 12g, Indigo Naturalis 1g.
Get above-mentioned raw materials medicine component according to selected weight portion, add customary adjuvant, conveniently technique, make mixture.Specifically comprise:
(1) Carapax Trionycis is got, Semen Persicae, Radix Salviae Miltiorrhizae, Radix Curcumae according to selected parts by weight, the Rhizoma Atractylodis Macrocephalae, Radix Ginseng, Eupolyphaga Seu Steleophaga, Rhizoma Cimicifugae, Herba Solidaginis, Rhizoma Paridis, Radix Isatidis, Radix Notoginseng, Rhizoma Cyperi, Herba Hedyotidis Diffusae, Poria and Indigo Naturalis, mixing, with 70% alcohol reflux of 12 volume times amount, reflux, extract, 3 times under maintenance temperature 70 C, each 1.5h, filter and collect filtrate, decompression recycling ethanol, to without alcohol taste, obtains alcohol extract;
(2) in the medicinal residues after the alcohol extraction in step (1), add the water extraction 2 times of 10 volume times amount again, each 2h, filters and collects filtrate, obtaining aqueous extract;
(3) merged by the aqueous extract obtained in the alcohol extract obtained in step (1) and step (2) and collect, concentrating under reduced pressure, obtains concentrated solution;
(4) by above-mentioned concentrated solution cold preservation 24 hours, filter, filtrate is boiled, and it is appropriate to add customary adjuvant, makes dissolving, filters, let cool, add water to 1000ml, stir evenly, embedding, sterilizing, namely obtains required mixture.
Embodiment 7
The crude drug being used for the treatment of the Chinese medicine composition of liver cirrhosis of the present embodiment consists of: Carapax Trionycis 3g, Semen Persicae 6g, Radix Salviae Miltiorrhizae 9g, Radix Curcumae 9g, Rhizoma Atractylodis Macrocephalae 13g, Radix Ginseng 3g, Eupolyphaga Seu Steleophaga 5g, Rhizoma Cimicifugae 5g, Herba Solidaginis 7g, Rhizoma Paridis 3g, Radix Isatidis 5g, Radix Notoginseng 4g, Rhizoma Cyperi 5g, Herba Hedyotidis Diffusae 7g, Poria 11g, Indigo Naturalis 6g.
Get above-mentioned raw materials medicine component according to selected weight portion, add customary adjuvant, conveniently technique, make drop pill.Specifically comprise:
(1) Carapax Trionycis is got, Semen Persicae, Radix Salviae Miltiorrhizae according to selected parts by weight, Radix Curcumae, the Rhizoma Atractylodis Macrocephalae, Radix Ginseng, Herba Hedyotidis Diffusae, Poria and Indigo Naturalis, mixing, with 90% alcohol reflux of 10 volume times amount, reflux, extract, 3 times at maintenance temperature 78 DEG C, each 4h, filters and collects filtrate, decompression recycling ethanol, to without alcohol taste, obtains alcohol extract;
(2) Eupolyphaga Seu Steleophaga is got, Rhizoma Cimicifugae, Herba Solidaginis, Rhizoma Paridis, Radix Isatidis according to selected parts by weight, Radix Notoginseng, Rhizoma Cyperi, mixing, by the water reflux, extract, of 7 volume times amount, reflux, extract, 2 times under maintenance temperature 60 C, each 1h, filters and collects filtrate, obtaining aqueous extract; (please applicant confirm according to above-mentioned steps crude drug order of addition successively whether can)
(3) merged by the aqueous extract obtained in the alcohol extract obtained in step (1) and step (2) and collect, concentrating under reduced pressure, obtains concentrated solution;
(4) above-mentioned concentrated solution is added customary adjuvant, conveniently technique, make drop pill.
Embodiment 8
The crude drug being used for the treatment of the Chinese medicine composition of liver cirrhosis of the present embodiment consists of: Carapax Trionycis 2g, Semen Persicae 8g, Radix Salviae Miltiorrhizae 6g, Radix Curcumae 12g, Rhizoma Atractylodis Macrocephalae 10g, Radix Ginseng 6g, Eupolyphaga Seu Steleophaga 4g, Rhizoma Cimicifugae 6g, Herba Solidaginis 4g, Rhizoma Paridis 6g, Radix Isatidis 4g, Radix Notoginseng 5g, Rhizoma Cyperi 4g, Herba Hedyotidis Diffusae 8g, Poria 10g, Indigo Naturalis 8g.
Get above-mentioned raw materials medicine component according to selected weight portion, add customary adjuvant, conveniently technique, make injection.Specifically comprise:
(1) Carapax Trionycis is got, Semen Persicae, Radix Salviae Miltiorrhizae according to selected parts by weight, Radix Curcumae, the Rhizoma Atractylodis Macrocephalae, Radix Ginseng, Herba Hedyotidis Diffusae, Poria and Indigo Naturalis, mixing, with 70% alcohol reflux of 12 volume times amount, reflux, extract, 3 times under maintenance temperature 70 C, each 1.5h, filters and collects filtrate, decompression recycling ethanol, to without alcohol taste, obtains alcohol extract;
(2) Eupolyphaga Seu Steleophaga is got, Rhizoma Cimicifugae, Herba Solidaginis, Rhizoma Paridis, Radix Isatidis according to selected parts by weight, Radix Notoginseng, Rhizoma Cyperi, mixing, by the water reflux, extract, of 10 volume times amount, reflux, extract, 2 times under maintenance temperature 60 C, each 3h, filters and collects filtrate, obtaining aqueous extract;
(3) merged by the aqueous extract obtained in the alcohol extract obtained in step (1) and step (2) and collect, concentrating under reduced pressure, obtains concentrated solution;
(4) filtered by above-mentioned concentrated solution, dilution, adjust ph, adds customary adjuvant, conveniently technique, makes injection.
Embodiment 9
The crude drug being used for the treatment of the Chinese medicine composition of liver cirrhosis of the present embodiment consists of: Carapax Trionycis 8g, Semen Persicae 2g, Radix Salviae Miltiorrhizae 12g, Radix Curcumae 6g, Rhizoma Atractylodis Macrocephalae 16g, Radix Ginseng 1g, Eupolyphaga Seu Steleophaga 10g, Rhizoma Cimicifugae 1g, Herba Solidaginis 10g, Rhizoma Paridis 1g, Radix Isatidis 10g, Radix Notoginseng 1g, Rhizoma Cyperi 10g, Herba Hedyotidis Diffusae 2g, Poria 12g, Indigo Naturalis 1g.
Get above-mentioned raw materials medicine component according to selected weight portion, add customary adjuvant, conveniently technique, make powder.Specifically comprise:
(1) Carapax Trionycis is got, Semen Persicae, Radix Salviae Miltiorrhizae, Radix Curcumae according to selected parts by weight, the Rhizoma Atractylodis Macrocephalae, Radix Ginseng, Eupolyphaga Seu Steleophaga, Rhizoma Cimicifugae, Herba Solidaginis, Rhizoma Paridis, Radix Isatidis, Radix Notoginseng, Rhizoma Cyperi, Herba Hedyotidis Diffusae, Poria and Indigo Naturalis, mixing, with 78% alcohol reflux of 12 volume times amount, reflux, extract, 3 times at maintenance temperature 85 DEG C, each 6h, filter and collect filtrate, decompression recycling ethanol, to without alcohol taste, obtains alcohol extract;
(2) in the medicinal residues after the alcohol extraction in step (1), add the water extraction 2 times of 9 volume times amount again, each 3h, filters and collects filtrate, obtaining aqueous extract;
(3) merged by the aqueous extract obtained in the alcohol extract obtained in step (1) and step (2) and collect, concentrating under reduced pressure, obtains concentrated solution;
(4) above-mentioned concentrated solution is added customary adjuvant, conveniently technique, make powder.
Embodiment 10
The crude drug being used for the treatment of the Chinese medicine composition of liver cirrhosis of the present embodiment consists of: Carapax Trionycis 6g, Semen Persicae 4g, Radix Salviae Miltiorrhizae 10g, Radix Curcumae 8g, Rhizoma Atractylodis Macrocephalae 15g, Radix Ginseng 2g, Eupolyphaga Seu Steleophaga 8g, Rhizoma Cimicifugae 2g, Herba Solidaginis 8g, Rhizoma Paridis 2g, Radix Isatidis 8g, Radix Notoginseng 2g, Rhizoma Cyperi 8g, Herba Hedyotidis Diffusae 4g, Poria 12g, Indigo Naturalis 3g.
Get above-mentioned raw materials medicine component according to selected weight portion, add customary adjuvant, conveniently technique, make electuary.Specifically comprise:
(1) Carapax Trionycis is got, Semen Persicae, Radix Salviae Miltiorrhizae, Radix Curcumae according to selected parts by weight, the Rhizoma Atractylodis Macrocephalae, Radix Ginseng, Eupolyphaga Seu Steleophaga, Rhizoma Cimicifugae, Herba Solidaginis, Rhizoma Paridis, Radix Isatidis, Radix Notoginseng, Rhizoma Cyperi, Herba Hedyotidis Diffusae, Poria and Indigo Naturalis, mixing, with 70% alcohol reflux of 10 volume times amount, reflux, extract, 2 times at maintenance temperature 85 DEG C, each 2h, filter and collect filtrate, less than 60 DEG C decompression recycling ethanols, to without alcohol taste, obtain alcohol extract;
(2) in the medicinal residues after the alcohol extraction in step (1), add the water extraction 3 times of 10 volume times amount again, each 1.5h, filters and collects filtrate, obtaining aqueous extract;
(3) merged by the aqueous extract obtained in the alcohol extract obtained in step (1) and step (2) and collect, concentrating under reduced pressure, obtains concentrated solution;
(4) above-mentioned concentrated solution is added customary adjuvant, conveniently technique, make electuary.
Clinical experiment example
Getting the preparation prepared in embodiments of the invention 1 is the elaboration that example carries out effect, clinical take for honeyed pill, oral, every day 2 times, each serving with 8 ~ 10g, 300 routine liver cirrhosis disease patient are treated, take 40-80 days continuously.Cure 290 examples, clinical effective 300 examples, invalid 0 example, overall cure rate reaches 97%.Follow-up Continuous Tracking follows up a case by regular visits to December, without recurrence.
Model case
Case 1
Zhang, 49 years old, man, within 2008, check there is liver cirrhosis in Chongqing the People's Hospital, treatment had no improvement more than a year always, also has no effect again, often with costalgia of chest, belly tympanites in other hospitalize.Introduce trial edition Chinese medicine composition by friend, eat 15 secondary altogether, the first five secondary on probation after left and right costalgia of chest and tympanites all alleviate, then adhere to having eaten 45 days, through examination in hospital, all are normal.Call-on back by phone after 1 year, health is fine, not recurrence.
Case 2
Zheng, 52 years old, man, ill have more than 5 years take traditional Chinese medicine always, Western medicine, all have no improvement, often have costalgia of chest, belly tympanites.Trial edition Chinese medicine composition 15 is secondary, has eaten about 7 days costalgia of chests and tympanites alleviates all to some extent, after adhere to eating 60 days, all are normal for examination in hospital.Call-on back by phone after 1 year, still very well, body weight increases several kilograms to health.
Case 3
Poplar, 47 years old, man, illly to take traditional Chinese medicine more than 4 years, Western medicine always, all has no improvement, often has costalgia of chest, belly tympanites.Trial edition Chinese medicine composition 10 is secondary, has eaten about 3 days costalgia of chests and tympanites alleviates all to some extent, after adhere to eating 45 days, all are normal for examination in hospital.Call-on back by phone after 1 year, health is front not worse than ill.
Case 4
Ma, 48 years old, man, ill seeking medical advice everywhere more than 7 years all had no improvement, often has costalgia of chest, belly tympanites.Trial edition Chinese medicine composition 15 is secondary, has eaten about 7 days costalgia of chests and tympanites alleviates all to some extent, after adhere to eating 60 days, all are normal for examination in hospital.Call-on back by phone after 1 year, health is fine.
Case 5
Chen, 32 years old, man, illly sought medical advice more than 4 years everywhere, took traditional Chinese medicine, Western medicine always, all had no improvement, often had costalgia of chest, belly tympanites.Trial edition Chinese medicine composition 15 is secondary, has eaten about 7 days costalgia of chests and tympanites alleviates all to some extent, after adhere to eating 40 days, all are normal for examination in hospital.Call-on back by phone after 1 year, health is fine.
Case 6
Chen, 47 years old, female.Illly to seek medical advice everywhere more than 4 years, take traditional Chinese medicine always, Western medicine, all have no improvement, often have costalgia of chest, belly tympanites.Trial edition Chinese medicine composition 15 is secondary, has eaten about 5 days costalgia of chests and tympanites alleviates all to some extent, after adhere to eating 60 days, all are normal for examination in hospital.Call-on back by phone after 1 year, health is fine.
Be more than concrete case, when proving that Chinese medicine composition of the present invention is used for the treatment of liver cirrhosis by the multinomial case of reality, good effect, cure rate are up to 97%, and relapse rate is low.It should be noted that, Chinese medicine composition of the present invention all has good therapeutic effect for the liver cirrhosis of each degree, and cure rate is higher.
Obviously, above-described embodiment is only for clearly example being described, and the restriction not to embodiment.For those of ordinary skill in the field, can also make other changes in different forms on the basis of the above description.Here exhaustive without the need to also giving all embodiments.And thus the apparent change of extending out or variation be still among the protection domain of the invention.

Claims (10)

1. one kind is used for the treatment of the Chinese medicine composition of liver cirrhosis, it is characterized in that, the crude drug of said composition consists of: Carapax Trionycis 1-8 weight portion, Semen Persicae 2-10 weight portion, Radix Salviae Miltiorrhizae 4-12 weight portion, Radix Curcumae 6-15 weight portion, Rhizoma Atractylodis Macrocephalae 8-16 weight portion, Radix Ginseng 1-8 weight portion, Eupolyphaga Seu Steleophaga 2-10 weight portion, Rhizoma Cimicifugae 1-8 weight portion, Herba Solidaginis 2-10 weight portion, Rhizoma Paridis 1-8 measures part, Radix Isatidis 2-10 weight portion, Radix Notoginseng 1-6 weight portion, Rhizoma Cyperi 2-10 weight portion, Herba Hedyotidis Diffusae 2-10 weight portion, Poria 4-12 weight portion, Indigo Naturalis 1-10 weight portion.
2. be used for the treatment of the Chinese medicine composition of liver cirrhosis as claimed in claim 1, it is characterized in that, the crude drug of said composition consists of: Carapax Trionycis 2-6 weight portion, Semen Persicae 4-8 weight portion, Radix Salviae Miltiorrhizae 6-10 weight portion, Radix Curcumae 8-12 weight portion, Rhizoma Atractylodis Macrocephalae 10-15 weight portion, Radix Ginseng 2-6 weight portion, Eupolyphaga Seu Steleophaga 4-8 weight portion, Rhizoma Cimicifugae 2-6 weight portion, Herba Solidaginis 4-8 weight portion, Rhizoma Paridis 2-6 weight portion, Radix Isatidis 4-8 weight portion, Radix Notoginseng 2-5 weight portion, Rhizoma Cyperi 4-8 weight portion, Herba Hedyotidis Diffusae 4-8 weight portion, Poria 10-12 weight portion, Indigo Naturalis 3-8 weight portion.
3. be used for the treatment of the Chinese medicine composition of liver cirrhosis as claimed in claim 1 or 2, it is characterized in that, the crude drug of said composition consists of: Carapax Trionycis 4 weight portion, Semen Persicae 6 weight portion, Radix Salviae Miltiorrhizae 8 weight portion, Radix Curcumae 10 weight portion, the Rhizoma Atractylodis Macrocephalae 12 weight portion, Radix Ginseng 4 weight portion, Eupolyphaga Seu Steleophaga 6 weight portion, Rhizoma Cimicifugae 4 weight portion, Herba Solidaginis 6 weight portion, Rhizoma Paridis 4 weight portion, Radix Isatidis 6 weight portion, Radix Notoginseng 3 weight portion, Rhizoma Cyperi 6 weight portion, Herba Hedyotidis Diffusae 6 weight portion, Poria 8 weight portion, Indigo Naturalis 5 weight portion.
4. add customary adjuvant by the arbitrary described Chinese medicine composition selectivity being used for the treatment of liver cirrhosis of claim 1-3, conveniently the acceptable clinically preparation made of technique.
5. preparation as claimed in claim 4, is characterized in that, comprise electuary, powder, tablet, granule, capsule, mixture, pill, injection or drop pill.
6. prepare a method for the arbitrary described Chinese medicine composition of claim 1-3, it is characterized in that: get Carapax Trionycis, Semen Persicae, Radix Salviae Miltiorrhizae according to selected weight portion, Radix Curcumae, the Rhizoma Atractylodis Macrocephalae, Radix Ginseng, Eupolyphaga Seu Steleophaga, Rhizoma Cimicifugae, Herba Solidaginis, Rhizoma Paridis, Radix Isatidis, Radix Notoginseng, Rhizoma Cyperi, Herba Hedyotidis Diffusae, Poria and Indigo Naturalis, selectivity adds customary adjuvant, conveniently technique, makes acceptable preparation clinically.
7. preparation method as claimed in claim 6, is characterized in that, comprise the steps:
Carapax Trionycis is got, Semen Persicae, Radix Salviae Miltiorrhizae, Radix Curcumae according to selected parts by weight, the Rhizoma Atractylodis Macrocephalae, Radix Ginseng, Eupolyphaga Seu Steleophaga, Rhizoma Cimicifugae, Herba Solidaginis, Rhizoma Paridis, Radix Isatidis, Radix Notoginseng, Rhizoma Cyperi, Herba Hedyotidis Diffusae, Poria and Indigo Naturalis, remix after pulverizing or pulverizing respectively, sieve after mixing, and selectivity adds customary adjuvant, conveniently technique, makes acceptable preparation clinically.
8. preparation method as claimed in claim 6, is characterized in that, comprise the steps:
Carapax Trionycis is got, Semen Persicae, Radix Salviae Miltiorrhizae, Radix Curcumae, the Rhizoma Atractylodis Macrocephalae, Radix Ginseng, Eupolyphaga Seu Steleophaga according to selected parts by weight, Rhizoma Cimicifugae, Herba Solidaginis, Rhizoma Paridis, Radix Isatidis, Radix Notoginseng, Rhizoma Cyperi, Herba Hedyotidis Diffusae, Poria and Indigo Naturalis, mixing, extracting in water, filters and collects filtrate, obtaining concentrated solution after concentrating under reduced pressure; Above-mentioned concentrated solution selectivity is added customary adjuvant, conveniently technique, make clinical acceptable preparation; Or
Carapax Trionycis is got, Semen Persicae, Radix Salviae Miltiorrhizae, Radix Curcumae, the Rhizoma Atractylodis Macrocephalae, Radix Ginseng, Eupolyphaga Seu Steleophaga according to selected parts by weight, Rhizoma Cimicifugae, Herba Solidaginis, Rhizoma Paridis, Radix Isatidis, Radix Notoginseng, Rhizoma Cyperi, Herba Hedyotidis Diffusae, Poria and Indigo Naturalis, mixing, adds ethanol extraction, filters and collect filtrate, obtaining concentrated solution after concentrating under reduced pressure; Above-mentioned concentrated solution selectivity is added customary adjuvant, conveniently technique, make clinical acceptable preparation.
9. preparation method as claimed in claim 6, is characterized in that, comprise the steps:
(1) get wherein one or more raw material components mixing according to selected parts by weight, add alcohol reflux, filter and collect filtrate, decompression recycling ethanol, to without alcohol taste, obtains alcohol extract;
(2) again according to raw material components mixing under selected parts by weight remainder, direct extracting in water, or mix extracting in water again with the medicinal residues after alcohol extraction in step (1), filter and collect filtrate, obtaining aqueous extract;
(3) merged by the aqueous extract obtained in the alcohol extract obtained in step (1) and step (2) and collect, concentrating under reduced pressure, obtains concentrated solution;
(4) above-mentioned concentrated solution selectivity is added customary adjuvant, conveniently technique, make clinical acceptable preparation.
10. the Chinese medicine composition for preparing of the arbitrary described Chinese medicine composition of claim 1-3 or the arbitrary described method of claim 6-9 is for the preparation of the purposes in treatment liver cirrhosis medicine.
CN201410611920.7A 2014-11-04 2014-11-04 Traditional Chinese medicine composition for treating liver cirrhosis, and preparation method and application thereof Pending CN104398971A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106309502A (en) * 2016-10-20 2017-01-11 北京农学院 Application of ground beetle enzymolysis extract in preparation of drugs for preventing and/or treating carbon tetrachloride liver injury

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1403147A (en) * 2002-10-24 2003-03-19 河北以岭医药研究院有限公司 Medicines composition for raising body's immunity and its prepn
CN102949677A (en) * 2012-12-03 2013-03-06 刘华 Liver-soothing and stagnation-relieving particles and preparation method thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1403147A (en) * 2002-10-24 2003-03-19 河北以岭医药研究院有限公司 Medicines composition for raising body's immunity and its prepn
CN102949677A (en) * 2012-12-03 2013-03-06 刘华 Liver-soothing and stagnation-relieving particles and preparation method thereof

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106309502A (en) * 2016-10-20 2017-01-11 北京农学院 Application of ground beetle enzymolysis extract in preparation of drugs for preventing and/or treating carbon tetrachloride liver injury
CN106309502B (en) * 2016-10-20 2019-04-23 北京农学院 Application of the eupolyphoge sinensis enzymatic hydrolyzed extract in preparation prevention and/or treatment carbon tetrachloride hepatic injury drug

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