CN105616874A - Liver cancer treatment pharmaceutical composition and preparation method thereof - Google Patents
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- SWGJCIMEBVHMTA-UHFFFAOYSA-K trisodium;6-oxido-4-sulfo-5-[(4-sulfonatonaphthalen-1-yl)diazenyl]naphthalene-2-sulfonate Chemical compound [Na+].[Na+].[Na+].C1=CC=C2C(N=NC3=C4C(=CC(=CC4=CC=C3O)S([O-])(=O)=O)S([O-])(=O)=O)=CC=C(S([O-])(=O)=O)C2=C1 SWGJCIMEBVHMTA-UHFFFAOYSA-K 0.000 description 1
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Abstract
The invention discloses a liver cancer treatment pharmaceutical composition and a preparation method thereof. The liver cancer treatment pharmaceutical composition is prepared from characteristic Guangxi Zhuang and Yao medicinal herbs: Hedyotis Diffusa, Herba Scutellariae Barbatae, Onychium Japonicum, Solanum Lyratum, Radix Sophorae Tonkinensis, Selaginella Doederleinii, Calculus Bovis Artifactus, Radix Arnebiae seu lithospermi, Fructus Akebia Trifoliata Koidz, Fructus Livistona Chinensis, Radix Stephaniae Tetrandrae, Plumbago Zeylanica, Radix Notoginseng, Resina Draconis, Venenum Bufonis, Rhizoma Pinelliae Preparata, Radix Aconiti Kusnezoffii preparata, Radix Ginseng, Herba Gynostemmatis Pentaphylli and Radix Glycyrrhizae. The characteristic Guangxi Zhuang and Yao medicinal herbs are prepared into capsules, tablets or granules which have efficacy in clearing heat, detoxicating, diminishing swelling, removing blood stasis, stopping bleeding, relieving pain, tonifying qi and strengthening foundation of the human body and are applicable to treatment of liver cancer.
Description
Technical field
The present invention relates to a kind of Chinese medicine preparation, particularly a kind of drug regimen treating hepatocarcinoma and production method thereof.
Background technology
Cancer term is malignant tumor and tumor, and the annual new cancer cases of China is about 3,120,000, and per minute just have 6 people to be diagnosed as malignant tumor; The annual whole nation is about 2,700,000 because of the case of cancer mortality, and per minute just have 5 people to die from cancer. The new cancer patient in the whole world 20% is in China, and the cancer mortality patient of 24% is in China. Wherein lung, hepatocarcinoma still occupy Cancer Mortality front two.
In the treatment of cancer, doctor trained in Western medicine can be divided mainly into three big classes: the chemotherapy of surgical resection, fractionated radiation treatments (radiotherapy) and use medicine. But no matter which kind for the treatment of means, all can damage allomeric function and the immunologic function of patient, make each organ-tissue functional disorder. Therefore when treating, generally all it is aided with Chinese medicine, with strengthening vital QI to eliminate pathogenic factors, strengthen systemic anticancer ability. When carrying out radiotherapy, chemotherapy, coordinate Chinese medicine can reduce toxicity, increase patient's resistivity, strengthen anticancer effect.
We pass through literature search, it has been found that some are about the drug regimen for the treatment of hepatocarcinoma, for instance:
1, Chinese patent, application number: CN201510142237.8, open (bulletin) number: CN104758749A
Application (patent right) people: Wang Lei. Summary: a kind of Chinese medicine composition treating hepatocarcinoma, belonging to technical field of Chinese medicines, it is prepared from by following Chinese crude drug: Herba Hedyotidis Diffusae, Rhizoma Sparganii, Venenum Bufonis, Fructus Akebiae, Radix Notoginseng, Radix Salviae Miltiorrhizae, Radix Sophorae Tonkinensis, Spina Gleditsiae, Radix Bupleuri, Herba Artemisiae Scopariae, Herba Taraxaci, Rhizoma Acori Graminei, Radix Sanguisorbae and Radix Glycyrrhizae. Good weight is as follows: Herba Hedyotidis Diffusae 10-48, Rhizoma Sparganii 10-48, Venenum Bufonis 0.05-0.5, Fructus Akebiae 10-32, Radix Notoginseng 2-12, Radix Salviae Miltiorrhizae 10-48, Radix Sophorae Tonkinensis 5-25, Spina Gleditsiae 5-25, Radix Bupleuri 10-40, Herba Artemisiae Scopariae 10-40, Herba Taraxaci 10-48, Rhizoma Acori Graminei 10-20, Radix Sanguisorbae 5-25, Radix Glycyrrhizae 5-60. Chinese medicine composition compatibility of the present invention use can blood circulation promoting and blood stasis dispelling, detoxicating and resolving stagnation of pathogens, removing obstruction in the collateral to relieve pain, it is suppressed that tumor growth, treat hepatocarcinoma.
2, Chinese patent, application number: CN02117062.2, open (bulletin) number: CN1454614A
Application (patent right) people: Zhang Dezhong summary: anti-cancer capsule and preparation method thereof belongs to the pure Chinese medicine capsule preparation for the treatment of pulmonary carcinoma, hepatocarcinoma, the brain cancer, nasopharyngeal carcinoma, esophageal carcinoma, gastric cancer, intestinal cancer, breast carcinoma, uterus carcinoma. This prescription Combined with Radiotherapy chemotherapy is taken, and can play efficacy enhancing and toxicity reducing, improve the effect of immunologic function and life quality. This prescription is made up of flavour of a drug such as Radix Panacis Quinquefolii, Radix Notoginseng, Herba Hedyotidis Diffusae, Herba Portulacae Grandiflorae, Spica Prunellae, Rhizoma Paridis, Radix Glycyrrhizaes, through secondary decoction, concentrated filtrate, refinement clear paste, and pulverizes and sieves, dries granule, fills capsule and form. Its function is strengthening vital QI to eliminate pathogenic factors, hard masses softening and resolving, benefiting qi and removing blood stasis, heat-clearing and toxic substances removing, all medicine harmonies, plays effect that dispersing tumor is anticancer altogether.
3, Chinese patent, application number: CN201010558679.8, open (bulletin) number: CN102058871A
Application (patent right) people: Dai Long. summary: a kind of Chinese medicinal effective-part composition with antitumor action and preparation method thereof, Chinese medicinal effective-part composition specifically extracted from Herba Hedyotidis Diffusae, the Radix Astragali and Gekko Swinhonis and preparation method thereof, belong to the field of Chinese medicines. this Chinese medicine composition is with from Herba Hedyotidis Diffusae, in the Radix Astragali and Gekko Swinhonis, extracted effective site is as the main component of medicine, add corresponding adjuvant, make pill, tablet, granule, hard capsule, mixture, drop pill, soft capsule, effervescent tablet, injection or injectable powder, for suppressing tumor growth, reduce tumor body, regulate immunologic function, improve body immunity, extend tumor patient life and effective tumor remission patient because of hands art, leukopenia caused by radiotherapy or chemotherapy, dizzy, fatigue and weakness, become thin, poor appetite, the untoward reaction such as nausea and vomiting, its effective ingredient is clear and definite, drug effect is notable, taking dose is little, dosage form variation, and it is easy to use, meet the requirement of the modernization of Chinese medicine, there is good development prospect.
4, Chinese patent, application number: CN01106271.1, open (bulletin) number: CN1311033A
Application (patent right) people: Yu Junyuan; Summary: a kind of Chinese medicine treating cancer, it is made up of full shortcake, the Radix Euphorbiae Pekinensis, Herba Hedyotidis Diffusae, Herba Scutellariae Barbatae, Radix Et Rhizoma Rhei, Rhizoma Coptidis raw material. They respectively account for following ratio by weight percentage: complete crisp 10-30, Radix Euphorbiae Pekinensis 20-40, Herba Hedyotidis Diffusae 5-25, Herba Scutellariae Barbatae 5-25, Radix Et Rhizoma Rhei 5-20, Rhizoma Coptidis 5-20. This medicine has no side effect, it is possible to eliminate, the growth of anticancer, and the kinds cancers such as pulmonary carcinoma, hepatocarcinoma, bladder cancer are had obvious therapeutic effect, and effective percentage reaches more than 80%, and cure rate is more than 40%.
Document above have recorded about the combination for treating hepatocarcinoma and other cancers, but the Chinese medicine composition identical with the present invention has no existing document and record.
Summary of the invention
It is an object of the invention to: based on Guangxi tradition strong precious jade minority area treatment hepatocarcinoma proved recipe, carry out test and improve, a kind of drug regimen being different from existing treatment hepatocarcinoma and preparation method thereof is provided to market.
The technical scheme is that: the medicine for the treatment of hepatocarcinoma is made up of the raw material of Chinese medicine of following parts by weight: Herba Hedyotidis Diffusae 6-15 part; Herba Scutellariae Barbatae 6-15 part; Herba Onychii japonici 6-15 part; Herba Solani Lyrati 6-15 part; Radix Sophorae Tonkinensis 1-6 part; Herba Selaginellae Doederleinii 6-15 part; Artificial Calculus Bovis's 0.1-0.3 part; Radix Arnebiae (Radix Lithospermi) 1-10 part; Fructus Akebiae 6-15 part; Chinese fanpalm seed 6-15 part; Radix Stephaniae Tetrandrae 2-10 part; Radix Plumbaginis Zeylanicae 1-10 part; Radix Notoginseng 0.1-3 part; Sanguis Draxonis 0.1-6 part; Venenum Bufonis 0.015-0.03 part; Rhizoma Pinelliae Preparata 3-9 part; Radix Aconiti Kusnezoffii Preparata 0.1-3 part; Radix Ginseng 0.1-3 part; Herb Gynostemmae Pentaphylli 6-15 part; 2 parts of Radix Glycyrrhizae.
The production method process that the present invention treats the medicine of hepatocarcinoma is as follows: Herba Hedyotidis Diffusae by weight ratio; Herba Scutellariae Barbatae; Herba Onychii japonici part; Herba Solani Lyrati; Radix Sophorae Tonkinensis; Herba Selaginellae Doederleinii; Artificial Calculus Bovis; Radix Arnebiae (Radix Lithospermi); Fructus Akebiae; Chinese fanpalm seed; Radix Stephaniae Tetrandrae; Radix Plumbaginis Zeylanicae; Radix Notoginseng; Sanguis Draxonis; Venenum Bufonis; Rhizoma Pinelliae Preparata; Radix Aconiti Kusnezoffii Preparata; Radix Ginseng; Herb Gynostemmae Pentaphylli; Radix Glycyrrhizae, adds 10-15 times of weight water heated and boiled 1-2 hour, filters, and medicinal residues add 5-10 times of weight water again and heavily boil 0.5-1 hour, filtering liquid medicine, medicinal liquid merges heating and is concentrated into 2-3 times of medicine volume, cooling; Add the ethanol of 3-6 times amount volumetric concentration 95% to concentration of alcohol 60-75%, it is put in 4-8 DEG C after stirring to stand 6-48 hour, filter, refilter after filtrate is put the medicinal liquid cooling that in ethanol recycling can, heating recovery ethanol obtains, and then add 95% ethanol of 3-6 times amount to concentration of alcohol to 60-75%, it is put in 4-8 DEG C after stirring to stand 6-48 hour, filter, refilter after filtrate is put the medicinal liquid cooling that in ethanol recycling can, heating recovery ethanol obtains, again medicine liquid heating is concentrated into paste, adding adjuvant, powder process dries, and is mixed and made into capsule, tablet or granule.
Medically research shows that the herbal component selected by the present invention has following effect:
Above-described Herba Hedyotidis Diffusae, [Classification system] HedyotisdiffusaWilld[calls]: Herba Hedyotidis Diffusae, Herba Turczaninowiae Fastigiatae, Radix Picriae felterrae. [meridian distribution of property and flavor]: bitter in the mouth, light, cold in nature. [function cures mainly]: dyspnea and cough due to lung-heat; Laryngopharynx swelling and pain; Intestinal carbuncle; Furuncle and phyma skin infection; Venom; The puckery pain of pyretic stranguria; Edema; Dysentery; Intestinal is scorching; Jaundice due to damp-heat; It is good at the multiple cancerous protuberance for the treatment of.
Above-described Herba Scutellariae Barbatae, [Classification system] ScutellariabarbataD.Don[calls]: and head grass, Herba Scutellariae indicae, Herba hyperici attenuati, toothbrush grass. [meridian distribution of property and flavor]: nature and flavor: pungent, flat. [function cures mainly]: heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling, reducing swelling and alleviating pain, anticancer effect; Appendicitis curing, hepatitis, stomachache, early hepatocarcinoma, pulmonary carcinoma, cervical cancer, mastitis etc.; The diseases such as external is controlled pain furuncle and treated, treating swelling and pain by traumatic injury.
Above-described Herba Onychii japonici, [Classification system] Onychiumjaponicum (Thunb.) Kunze[calls]: stone Herba Asplenii Sarelii, celestial chicken tail, onychium japonicum Kunze, string Chara fragilis Desv., number of people grass, Herba Stenolomatis Chusani, little Herba Stenolomatis Chusani, fire soup Herba pteridii latiusculi, line chicken tail Herba pteridii latiusculi careless, black, wind WEILIAN, Radix seu caulis Berberidis Gagnepainii (Radix Berberidis Virgetori), Herba Asplenii Sarelii, 60 grass, Herba Pteridis creticae grass, detoxify Herba pteridii latiusculi, burn Herba pteridii latiusculi. [meridian distribution of property and flavor]: [nature and flavor] are bitter, cold. [function cures mainly]: heat-clearing and toxic substances removing, dampness removing, for cold, fever, cough, tonsillitis, parotitis, enteritis, dysentery, hepatitis, alimentary toxicosis, pesticide intoxication; Burn and scald, skin eczema are controlled in external.
Above-described Herba Solani Lyrati, [Classification system] SolanumlyratumThunb[calls]: mountain Radix Betae, Pennisetum centrasiaticum Tzvel, white curtain, air draft, air draft grass, Herba Bryophylli Pinnati, shaven head grass. [meridian distribution of property and flavor]: hide hardship, is slightly cold, and enters liver, gallbladder meridian [function cures mainly]: has heat-clearing and toxic substances removing, expelling wind and removing dampness, the effect such as anticancer, is used for treating the diseases such as cold, fever, icterohepatitis, cholecystitis, cholelithiasis, oedema due to nephritis, cervical erosion, cancer.
Above-described Radix Sophorae Tonkinensis, [Classification system] RadixSophoraeTonkinensis[calls]: root of subprostrate sophora, Herba Astragali Melilotoidis, mountain Soybean Root [meridian distribution of property and flavor]: bitter, cold; Poisonous. Attach to the lung and stomach meridians. [function cures mainly]: have heat-clearing and toxic substances removing, effect of detumescence sore-throat relieving, be usually used in fire-toxin and pent up, tonsillitis sore throat, laryngopharynx swelling and pain, gingivitis, aphtha of the mouth and tongue.
Above-described Herba Selaginellae Doederleinii, [Classification system] LonicerajaponicaThunb[call]: selaginella doederleinii, Cacumen Platycladi, Roegneria thoroldiana, Marchantia polymorpha L., Jin Longcao, Herba Titanotrichi oldhamii. [meridian distribution of property and flavor]: sweet in the mouth, micro-hardship, puckery, cool in nature. Return lung, Liver Channel. [function cures mainly]: there is heat-clearing and toxic substances removing, anticancer, effect of hemostasis. It is usually used in laryngopharynx swelling and pain, conjunctival congestion and swelling pain, cough due to lung-heat, mastitis, jaundice due to damp-heat, rheumatic arthralgia, traumatic hemorrhage.
Above-described artificial Calculus Bovis, [meridian distribution of property and flavor]: sweet in the mouth, cool in nature. GUIXIN, Liver Channel. [function cures mainly]: there is heat-clearing and toxic substances removing, the effect of arresting convulsion of reducing phlegm. Be usually used in the hot delirium of expectorant, coma in silence, acute infantile convulsion wind, laryngopharynx swelling and pain, aphtha of the mouth and tongue, the treatment of the diseases such as carbuncle furuncle.
Above-described Radix Arnebiae (Radix Lithospermi) [Classification system] Lithospermumerythrorhizon[calls]: gromwell root, big Radix Arnebiae (Radix Lithospermi), Asia puecon grass, purple red, ground blood, crow rank grass, Radix Arnebiae (Radix Lithospermi), mountain Radix Arnebiae (Radix Lithospermi) [meridian distribution of property and flavor]: nature and flavor: bitter, cold. [function cures mainly]: removing heat from blood, invigorates blood circulation, heat clearing away, removing toxic substances. Control warm macule, jaundice due to damp-heat, purpura, tell, be defeated in battle, hematuria, stranguria with turbid discharge, constipation with heat retention, burn, eczema, erysipelas, carbuncle and ulcer.
Above-described Fructus Akebiae, [Classification system] Akebiaquinata[calls]: Fructus Akebiae, August be fried, wild hair egg. [meridian distribution of property and flavor]: sweet, cold. Return liver,spleen,kidney warp. [function cures mainly]: for stomachache due to hyperactive liver-QI attacking the stomach, gastric heat food is slow-witted, excessive thirst, also Hakuri, lumbago, hypochondriac pain, hernia, menopause, and uterus drops.
Above-described Chinese fanpalm seed, [Classification system] Livistonachinensis(Jacq.) Br.[another name]: seed of Livistona chinensis R.Br.. [meridian distribution of property and flavor]: sweet in the mouth; Bitter; Property is put down; Mild toxicity. [function cures mainly]: blood circulation promoting and blood stasis dispelling; Hard masses softening and resolving. Main chronic hepatitis; Lump in the abdomen
Above-described Radix Stephaniae Tetrandrae, [Classification system] StephaniatetrandraS.Moore[calls]: Radix Stephaniae Tetrandrae, Radix Cocculi Orbiculati, little Radix Stephaniae Tetrandrae, powder Radix Stephaniae Tetrandrae, Radix Aristolochiae Fangchi,, gold thread fishes calabash root, Corten Ampelopsis Aconitifoliae Radicis root, Lignum Aquilariae Resinatum to powder cun, fall down to the ground arch, soil Radix Stephaniae Tetrandrae, stone Bufo siccus, Bufo siccus potato, Radix Polygalae Crotalarioidis, FANGQI, radix aristolochiae heterophyllae, dissociate, load monarch's row, Radix Stephaniae Tetrandrae, Stephania cepharatha Hayata, spun gold hangs Trionyx sinensis Wiegmann, Radix Stephaniae Tetrandrae Fructus Aristolochiae, Radix Aristolochiae, little cocculi, white mountain Ipomoea batatas Lam., Caulis Cocculi Trilobi, Caulis Sinomenii root, little Pueraria lobata root, radix aristolochiae heterophyllae root, Lignum Aquilariae Resinatum, bitter Radix Stephaniae Tetrandrae. [meridian distribution of property and flavor]: bitter in the mouth; Pungent; Cold in nature; Return bladder; Lung; Spleen channel. [function cures mainly]: inducing diuresis to remove edema; Wind-expelling pain-stopping. Main edema; Dysuria; Rheumatic arthralgia; Beriberi swells and ache; Scabies skin ulcer swells; Hypertension etc.
Above-described Radix Plumbaginis Zeylanicae, [Classification system] RadixPlumbaginisZeylanicae[calls]: white snowflake, white soap medicine, mountain ripple Siberian cocklebur, see and disappear, Wu Mianma, fire miracle, false jasmine, violent tiger, spend Rhizoma Rodgersiae in vain. [nature and flavor]: bitter, tepor. Poisonous. [function cures mainly]: wind-expelling pain-stopping, dissipating blood stasis for subsidence of swelling. Root: rheumatic ostalgia, treating swelling and pain by traumatic injury, stomachache, hepatosplenomegaly. Leaf: treating swelling and pain by traumatic injury, bruise, tinea corporis are controlled in external.
Above-described Radix Notoginseng, [Classification system] RadixNotoginseng[calls]: Radix Notoginseng, Panax pseudoginseng, Radix Notoginseng. [meridian distribution of property and flavor]: hardship sweet, micro-, temperature. Return liver, stomach warp. [function cures mainly]: be used for spitting blood, spits blood, and epistaxis is had blood in stool, metrorrhagia, traumatic hemorrhage, chest and abdomen twinge, tumbling and swelling.
Above-described Sanguis Draxonis, [Classification system] RESINADRACONIS[meridian distribution of property and flavor]: warm in nature, flat, sweet in the mouth, salty, nontoxic, enter blood system, return lung, spleen, kidney three warp. [function cures mainly]: blood circulation promoting and blood stasis dispelling, reducing swelling and alleviating pain, astringing to arrest bleeding, hard masses softening and resolving, promoting tissue regeneration and ulcer healing, improve body microcirculation, adjust body metabolism, improve the effects such as body's immunity.
Above-described Venenum Bufonis, [Classification system] VenenumBufonis[calls]: cinobufagin; Cinobufacin; Bufogenin. [meridian distribution of property and flavor]: sweet in the mouth, pungent, warm in nature, poisonous. [function cures mainly]: removing toxic substances, detumescence, heart tonifying, pain relieving. Control furuncle, carbuncle, carbuncle on the back, scrofula, chronic osteomyelitis, laryngopharynx swelling and pain, infantile malnutrition, heart failure, wind, carious pain. Heat-clearing and toxic substances removing. Main cough expectorant is thick; Laryngopharynx swelling and pain; Breast is vexed; Constipation; Carbuncle furuncle; Venom. And there is antitumor and radiation resistance.
Above-described Rhizoma Pinelliae Preparata, [Classification system] RhizomaPinelliae[calls]: ground literary composition, water are beautiful, keep field, show aunt, the sheep eye Rhizoma Pinelliae, and aunt, Sedum spectabile Boreau, the ground pearl Rhizoma Pinelliae, fiber crops taro fruit, three step jumping, general stone, the Rhizoma Pinelliae are sub, ground Francolini pintadeani, arrowhead, strong yellow mouth, old shaven head, YEYUTOU, crow head, catch garbanzo, ground Fructus Crotonis, be not in the mood for dish root, sky falls star, corbie eye, fiber crops taro, ground Thunder God, old melon Bulbus Allii, Canis familiaris L. Fructus Colocasiae Esculentae, the pearl Rhizoma Pinelliae, splits cutter dish, fiber crops grass seed. [meridian distribution of property and flavor]: pungent, warm. Return spleen, stomach, lung meridian. [function cures mainly]: drying dampness to eliminate phlegm. For abundant expectoration cough with asthma, phlegm retention vertigo and palpitation, dizziness due to wind-phlegm, syncope due to accumulation of phlegm is had a headache.
Above-described Radix Aconiti Kusnezoffii Preparata [Classification system] RadixAconitiKusnezoffii[calls]: Aconitum carmichjaelii Debx., five poisonous creatures: scorpion, viper, centipede, house lizard, toad root [meridian distribution of property and flavor]: acrid in the mouth, hardship, hot in nature. The heart, liver,kidney,spleen warp. [function cures mainly]: expelling wind and removing dampness, antalgic. For anemofrigid-damp arthralgia, arthralgia, trusted subordinate's cold type of pain, colic of cold type is had a pain, narcotic analgesic.
Above-described Radix Ginseng, [Classification system] PanaxginsengC.A.Mey.[calls]: Radix Ginseng Sativus, Sphallerocarpus gracilis, wooden club, people's rank, Coprinus atramentarius (Bull.) Fr. (Coprinus sterquilinus Fr.), SHENCAO, Rhizoma Panacis Japonici, Herba Stellariae Saxatilis, sea fat, people. [meridian distribution of property and flavor]: sweet in the mouth, micro-hardship, warm in nature, flat. Return spleen, lung meridian, heart channel. [function cures mainly]: weak body and prostration, cold extremities faint pulse, insufficiency of the spleen lack of appetite, the deficiency of the lung is breathed with cough, and Tianjin wound is thirsty, and interior-heat is quenched one's thirst, prolonged illness weakness with emaciation, palpitation with fear insomnia, sexual impotence cold womb; Heart failure, cardiogenic shock. For dyspnea with shortness of breath, palpitation and amnesia, thirsty hyperhidrosis, lack of appetite is unable, all acute and chronic diseases and the shock caused after losing blood, collapse. Strongly invigorating primordial QI, promotes the production of body fluid Gu de-, calms the nerves. Controlling impairment caused by overstrain deficient, lack of appetite, asthenia, food is told in regurgitation, lingering diarrhea of defecating, and empty cough with asthma is urged, spontaneous perspiration sudden collapse, and palpitation with fear is forgetful, dizziness and headache, sexual impotence, and frequent micturition is quenched one's thirst, woman uterine bleeding, children's's intermittent infantile convulsion, and prolonged deficiency is not multiple, the card of all qi-blood-body fluid deficiencies. Strengthen resistance of human body.
Above-described Herb Gynostemmae Pentaphylli, [Classification system] Gynostemmapentaphyllum (Thunb.) Makino[calls]: Herba Gynostemmatis, Pentapanax, gynostemma pentaphyllum makino, Herba Gynostemmatis. [meridian distribution of property and flavor]: bitter in the mouth; Micro-sweet; Cool in nature. Return lung; Spleen; Kidney channel. [function cures mainly]: body void is weak; Nephrasthenia emission; Leukopenia; Hyperlipemia; Viral hepatitis; Chronic gastroenteritis; Chronic tracheitis.
Above-described Radix Glycyrrhizae, [Classification system] GlycyrrhizauralensisFisch[calls]: Herba Hedyotis cantonensis root, Radix Glycyrrhizae, Radix Glycyrrhizae, Glycyrrhiza uralensis Fisch.. [meridian distribution of property and flavor]: sweet, flat. GUIXIN, lung, spleen, stomach warp. [function cures mainly] invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription. For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, gastral cavity abdomen, extremity contraction urgency pain, carbuncle sore tumefacting virus, cushion toxicity, strong.
The present invention has the pharmacological function of each composition in the capsule for the treatment of hepatocarcinoma effect:
In side bitter with Herba Hedyotidis Diffusae nature and flavor, sweet, cold, enter the heart, liver, spleen three warp, there is heat-clearing and toxic substances removing, heat clearing away scattered silt effect, Herba Scutellariae Barbatae acrid in the mouth, hardship, cold in nature, returning lung, Liver and kidney warp, have the function of heat-clearing and toxic substances removing, blood stasis dispelling diuresis, Herba Onychii japonici nature and flavor are bitter, cold, there is heat-clearing and toxic substances removing, dampness removing, effect of hemostasis, above three is monarch drug altogether. It is aided with Herba Solani Lyrati, Radix Sophorae Tonkinensis, Herba Selaginellae Doederleinii, artificial Calculus Bovis, Radix Arnebiae (Radix Lithospermi), Fructus Akebiae, Chinese fanpalm seed, Radix Stephaniae Tetrandrae to strengthen monarch drug heat-clearing and toxic substances removing, dehumidifying detumescence, cooling blood for hemostasis effect. With Radix Plumbaginis Zeylanicae, Radix Notoginseng, Sanguis Draxonis, Venenum Bufonis, Rhizoma Pinelliae Preparata, Radix Aconiti Kusnezoffii Preparata with blood circulation promoting and blood stasis dispelling, reducing swelling and alleviating pain; Radix Ginseng, Herb Gynostemmae Pentaphylli strongly invigorating primordial QI, reinforcement and elimination in combination, is adjuvant drug altogether. With Radix Glycyrrhizae invigorating the spleen and replenishing QI, relieving spasm to stop pain, the property of medicine can be relaxed again and for making medicine.
Beneficial effects of the present invention:
1, prescription of the present invention comes from Guangxi Zhuang precious jade minority area treatment hepatocarcinoma proved recipe; it is combined into according to the strong precious jade medical material special efficacy of Chinese tradition Chinese medical theory and the principles of formulating prescriptions and Guangxi characteristic; be conducive to developing further the herb resource in Guangxi; help the development of poverty-stricken minority areas Chinese herbal medicine plant husbandry; protection and development of national medicinal career, make ethnic minority traditional medicine develop. In combination with clinical, economical convenient, it is adaptable to situation of all-level hospitals, it is particularly suitable for medical condition poor, lacks qualified technical personnel, the basic hospital of financial difficulties is for anticancer treatment. To Economy type medicine cost, promote social stability, safeguard that human health is significant.
2, the above medical material of the present invention all has antitumor action through its pharmacological testing of Literature Consult or has been used for the various cancer of clinical treatment, existing all medicines share, consolidating effect up to heat-clearing and toxic substances removing, detumescence, hemostasis analgesic therapy, QI invigorating, it is adaptable to the treatment of hepatocarcinoma, effect is compared with the existing medicine in market more preferably.
3, the present invention adopts pure Chinese medicinal preparation, and side effect is little, recovers patient's vigour, alleviates the western medicine therapy side effect misery to patient.
4, manufacturing process flow process of the present invention is simple, maximizes and retains the plurality of active ingredients treating hepatocarcinoma in various raw materials.
Detailed description of the invention
Embodiment 1
Take following raw material (weight portion): Herba Hedyotidis Diffusae 6 parts; Herba Scutellariae Barbatae 6 parts; Herba Onychii japonici 6 parts; Herba Solani Lyrati 6 parts; Radix Sophorae Tonkinensis 1 part; Herba Selaginellae Doederleinii 6 parts; Artificial Calculus Bovis 0.1 part; Radix Arnebiae (Radix Lithospermi) 1 part; Fructus Akebiae 6 parts; Chinese fanpalm seed 6 parts; Radix Stephaniae Tetrandrae 2 parts; Radix Plumbaginis Zeylanicae 1 part; Radix Notoginseng 0.1 part; Sanguis Draxonis 0.1 part; Venenum Bufonis 0.015 part; Rhizoma Pinelliae Preparata 3 parts; Radix Aconiti Kusnezoffii Preparata 0.1 part; Radix Ginseng 0.1 part; Herb Gynostemmae Pentaphylli 6 parts; 2 parts of Radix Glycyrrhizae; Weigh above-mentioned clean medical material, chopping, weigh rear mix homogeneously by described weight portion, add 10 times of water heated and boiled 1 hour, filter, medicinal residues add 5 times amount water again and heavily boil 0.5 hour, filtering liquid medicine, medicinal liquid merges heating and is concentrated into 2 times of medicine volumes, cooling; Add the ethanol of 3 times amount volumetric concentrations 95% to concentration of alcohol 60%, it is put in 4 DEG C after stirring to stand 10 hours, filters, refilter after filtrate is put the medicinal liquid cooling that in ethanol recycling can, heating recovery ethanol obtains, and then add 95% ethanol of 3 times amount to concentration of alcohol to 60%, it is put in 4 DEG C after stirring to stand 10 hours, filters, refilter after filtrate is put the medicinal liquid cooling that in ethanol recycling can, heating recovery ethanol obtains, again medicine liquid heating is concentrated into paste, adding adjuvant, powder process dries, and is mixed and made into capsule.
Embodiment 2
Take following raw material (weight portion):
Herba Hedyotidis Diffusae 15 parts; Herba Scutellariae Barbatae 15 parts; Herba Onychii japonici 15 parts; Herba Solani Lyrati 15 parts; Radix Sophorae Tonkinensis 6 parts; Herba Selaginellae Doederleinii 15 parts; Artificial Calculus Bovis 0.3 part; Radix Arnebiae (Radix Lithospermi) 10 parts; Fructus Akebiae 15 parts; Chinese fanpalm seed 15 parts; Radix Stephaniae Tetrandrae 10 parts; Radix Plumbaginis Zeylanicae 10 parts; Radix Notoginseng 3 parts; Sanguis Draxonis 6 parts; Venenum Bufonis 0.03 part; Rhizoma Pinelliae Preparata 9 parts; Radix Aconiti Kusnezoffii Preparata 3 parts; Radix Ginseng 3 parts; Herb Gynostemmae Pentaphylli 15 parts; 2 parts of Radix Glycyrrhizae; By weight ratio Herba Hedyotidis Diffusae, Herba Scutellariae Barbatae, Herba Onychii japonici part, Herba Solani Lyrati, Radix Sophorae Tonkinensis, Herba Selaginellae Doederleinii, artificial Calculus Bovis, Radix Arnebiae (Radix Lithospermi), Fructus Akebiae, Chinese fanpalm seed, Radix Stephaniae Tetrandrae, Radix Plumbaginis Zeylanicae, Radix Notoginseng, Sanguis Draxonis, Venenum Bufonis, Rhizoma Pinelliae Preparata, Radix Aconiti Kusnezoffii Preparata, Radix Ginseng, Herb Gynostemmae Pentaphylli, Radix Glycyrrhizae, add 15 times of water heated and boiled 2 hours, filter, medicinal residues add 10 times amount water again and heavily boil 1 hour, filtering liquid medicine, medicinal liquid is merged heating and is concentrated into 3 times of medicine volumes, cooling; Add the ethanol of 6 times amount volumetric concentrations 95% to concentration of alcohol 75%, it is put in 8 DEG C after stirring to stand 48 hours, filters, refilter after filtrate is put the medicinal liquid cooling that in ethanol recycling can, heating recovery ethanol obtains, and then add 95% ethanol of 6 times amount to concentration of alcohol to 75%, it is put in 8 DEG C after stirring to stand 48 hours, filters, refilter after filtrate is put the medicinal liquid cooling that in ethanol recycling can, heating recovery ethanol obtains, again medicine liquid heating is concentrated into paste, adding adjuvant, powder process dries, and is mixed and made into tablet.
Embodiment 3
Take following raw material (weight portion):
Herba Hedyotidis Diffusae 10 parts; Herba Scutellariae Barbatae 10 parts; Herba Onychii japonici 10 parts; Herba Solani Lyrati 10 parts; Radix Sophorae Tonkinensis 5 parts; Herba Selaginellae Doederleinii 10 parts; Artificial Calculus Bovis 0.2 part; Radix Arnebiae (Radix Lithospermi) 8 parts; Fructus Akebiae 10 parts; Chinese fanpalm seed 10 parts; Radix Stephaniae Tetrandrae 8 parts; Radix Plumbaginis Zeylanicae 9 parts; Radix Notoginseng 2 parts; Sanguis Draxonis 5 parts; Venenum Bufonis 0.02 part; Rhizoma Pinelliae Preparata 7 parts; Radix Aconiti Kusnezoffii Preparata 2 parts; Radix Ginseng 2 parts; Herb Gynostemmae Pentaphylli 12 parts; 1 part of Radix Glycyrrhizae; By weight ratio Herba Hedyotidis Diffusae, Herba Scutellariae Barbatae, Herba Onychii japonici part, Herba Solani Lyrati, Radix Sophorae Tonkinensis, Herba Selaginellae Doederleinii, artificial Calculus Bovis, Radix Arnebiae (Radix Lithospermi), Fructus Akebiae, Chinese fanpalm seed, Radix Stephaniae Tetrandrae, Radix Plumbaginis Zeylanicae, Radix Notoginseng, Sanguis Draxonis, Venenum Bufonis, Rhizoma Pinelliae Preparata, Radix Aconiti Kusnezoffii Preparata, Radix Ginseng, Herb Gynostemmae Pentaphylli, Radix Glycyrrhizae, add 15 times of water heated and boiled 2 hours, filter, medicinal residues add 10 times amount water again and heavily boil 1 hour, filtering liquid medicine, medicinal liquid is merged heating and is concentrated into 3 times of medicine volumes, cooling; Add the ethanol of 6 times amount volumetric concentrations 95% to concentration of alcohol 75%, it is put in 8 DEG C after stirring to stand 48 hours, filter, refilter after filtrate is put the medicinal liquid cooling that in ethanol recycling can, heating recovery ethanol obtains, and then add 95% ethanol of 6 times amount to concentration of alcohol to 75%, it is put in 8 DEG C after stirring to stand 48 hours, filter, refilter after filtrate is put the medicinal liquid cooling that in ethanol recycling can, heating recovery ethanol obtains, again medicine liquid heating is concentrated into paste, add sucrose or fructose mix homogeneously, make granule.
Treatment liver cancer efficacy
Effective treatment rate of hepatocarcinoma, through 284 example Clinical Laboratorys in 3 years, is reached 75.3% by invention formulation.
The present invention uses above-described embodiment for volunteer 15 example for 2015, wherein 10 examples find as hepatocarcinoma in mid-term, 5 examples are advanced liver cancer symptom, it is for oral administration that the paste semi-finished product (not making capsule, tablet or granule) that obtain of method for making adopting embodiment 1-3 give the furnishing medicinal liquid bath that adds water of 15 examples, within 1 month, check, 10 example hepatocarcinoma in mid-term have 5 examples to reduce as a result, and it is big that 3 example tumors do not develop change; It is big that 5 example advanced liver cancer patients have 4 example tumors not develop change, has an example transfer death of illness.
Application Example:
Embodiment 1: Liu X, man, people from Guangxi Hechi, 35 years old, office's white collar, find in May, 2014 and suffer from hepatocarcinoma mid-term, AFP4500ng/L has also carried out interventional therapy June in the same year, and Post operation starts to take this medicament capsule June, every day 2 times, each 5, every 0.5g. Taking (in December, 2015) so far continuously, AFP is down to 52ng/L hepatocarcinoma and does not recur and shift, and liver function indices is normal.
Embodiment 2: Zhu X, man, people from Liuzhou, 61 years old, retired employees, hepatitis B virus carriers, in November, 2013, appetite declined, jaundice. CT detects liver cirrhosis, hepatocarcinoma, and AFP3200ng/L2014 carries out operative treatment February. Started to take this medicament capsule postoperative this month, every day 2 times, each 3, every 0.75g. Taking (in December, 2015) so far continuously, patient's hepatocarcinoma does not recur and shifts, and AFP is down to normal level, and physical condition is good, it is possible to take care of oneself, and appetite increases, and can carry out slight physical training.
Embodiment 3: Lee X, man, Guangxi autonomous county of the Yao nationality, 52 years old, Enterprise Staff, in August, 2011 health check-up detection 2X2.3mm liver lesion, detects AFP580ng/L. The same year, JIUYUE carried out resection operation. Postoperative start to take this medicament capsule, every day 2 times, each 3, every 0.75g, take continuously 2 years, nowadays physical condition is good, and life and normal person are as good as.
Embodiment 4: old X, man, people from Nanning, 45 years old, long-distance truck driver, find inappetence in February, 2012, liver's pain, being hepatocarcinoma at hospital CT and ultrasound diagnosis, April in the same year carries out hepatectomy, hepatectomizes 40%, start after leaving hospital to take this medicament capsule, every day 3 times, each 4, every 0.5g. Take (in December, 2015) so far continuously. Cancer does not recur so far and shifts, and patient lives and substantially takes care of oneself.
Claims (3)
1. the medicine treating hepatocarcinoma, it is characterised in that be made up of the raw material of Chinese medicine of following parts by weight: Herba Hedyotidis Diffusae 6-15 part; Herba Scutellariae Barbatae 6-15 part; Herba Onychii japonici 6-15 part; Herba Solani Lyrati 6-15 part; Radix Sophorae Tonkinensis 1-6 part; Herba Selaginellae Doederleinii 6-15 part; Artificial Calculus Bovis's 0.1-0.3 part; Radix Arnebiae (Radix Lithospermi) 1-10 part; Fructus Akebiae 6-15 part; Chinese fanpalm seed 6-15 part; Radix Stephaniae Tetrandrae 2-10 part; Radix Plumbaginis Zeylanicae 1-10 part; Radix Notoginseng 0.1-3 part; Sanguis Draxonis 0.1-6 part; Venenum Bufonis 0.015-0.03 part; Rhizoma Pinelliae Preparata 3-9 part; Radix Aconiti Kusnezoffii Preparata 0.1-3 part; Radix Ginseng 0.1-3 part; Herb Gynostemmae Pentaphylli 6-15 part; 2 parts of Radix Glycyrrhizae.
2. the medicine of the treatment hepatocarcinoma according to claim l, it is characterised in that: described Chinese medicine preparation is capsule, tablet or granule.
3. the medicine of the treatment hepatocarcinoma described in claim 1 or 2, it is characterized in that: the production process of Chinese medicine preparation is as follows: Herba Hedyotidis Diffusae by weight ratio, Herba Scutellariae Barbatae, Herba Onychii japonici part, Herba Solani Lyrati, Radix Sophorae Tonkinensis, Herba Selaginellae Doederleinii, artificial Calculus Bovis, Radix Arnebiae (Radix Lithospermi), Fructus Akebiae, Chinese fanpalm seed, Radix Stephaniae Tetrandrae, Radix Plumbaginis Zeylanicae, Radix Notoginseng, Sanguis Draxonis, Venenum Bufonis, Rhizoma Pinelliae Preparata, Radix Aconiti Kusnezoffii Preparata, Radix Ginseng, Herb Gynostemmae Pentaphylli, Radix Glycyrrhizae, add 10-15 times of weight water heated and boiled 1-2 hour, filter, medicinal residues add 5-10 times of weight water again and heavily boil 0.5-1 hour, filtering liquid medicine, medicinal liquid is merged heating and is concentrated into 2-3 times of medicine volume, cooling, add the ethanol of 3-6 times amount volumetric concentration 95% to concentration of alcohol 60-75%, it is put in 4-8 DEG C after stirring to stand 6-48 hour, filter, refilter after filtrate is put the medicinal liquid cooling that in ethanol recycling can, heating recovery ethanol obtains, and then add 95% ethanol of 3-6 times of weight to concentration of alcohol to 60-75%, it is put in 4-8 DEG C after stirring to stand 6-48 hour, filter, refilter after filtrate is put the medicinal liquid cooling that in ethanol recycling can, heating recovery ethanol obtains, again medicine liquid heating is concentrated into paste, add adjuvant, be mixed and made into capsule, tablet or granule.
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| CN107126527A (en) * | 2017-05-22 | 2017-09-05 | 何东良 | A kind of Chinese medicine composition and its preparation for treating liver cancer |
| CN108635364A (en) * | 2018-05-14 | 2018-10-12 | 杨真慧 | It is a kind of to be used to substitute composition and its assay method that indian skullcap herb with root prepares treatment of human cervical cancer drug |
| CN108635364B (en) * | 2018-05-14 | 2019-04-05 | 海门市彼维知识产权服务有限公司 | A kind of composition and its measuring method preparing treatment of human cervical cancer drug for substituting indian skullcap herb with root |
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Application publication date: 20160601 |