CN105688158A - Chinese herb preparation for treating autoimmune liver disease and preparing method of Chinese herb preparation - Google Patents

Abstract

The invention discloses a Chinese herb preparation for treating an autoimmune liver disease and belongs to the field of Chinese medicine inventions. The Chinese herb preparation is prepared from heterophylly falsestarwort roots, stir-baked radix paeoniae alba, roasted rhizoma atractylodis macrocephalae, stir-fried semen coicis, radix astragali preparata, divaricate saposhnikovia roots, hairyvein agrimonia herb and buds, pericarpium citri reticulatae, rhizoma pinelliae, dried ginger, radix angelica sinensis, poria cocos, cassia twigs, christina loosestrife herb, herba artemisiae scopariae, rhizoma alismatis, akebia fruits, turmeric root tubers, puncture vine caltrop fruits, endothelium corneum gigeriae galli prepared in vinegar, szechwan chinaberry fruits, rhizoma corydalis, unprocessed rehmannia roots, stir-baked jasmine flowers, red dates and unprepared licorice roots. The medicine materials are subjected to thorough washing and stripping and slicing pretreatment and then matched according to a proportion according to different characteristics of all the medicine materials, and the Chinese herb preparation is prepared with a special method and has the effects of nourishing blood and tonifying qi, warming the channels and reinforcing yang, tonifying the spleen and eliminating dampness, and regulating qi-flowing for eliminating phlegm. The product composition and the preparing method are unique, and it is clinically verified that the Chinese herb preparation is remarkable in treatment effect, short in treatment cycle, low in price, and free of adverse reactions and toxic or side effects, and has wide market application prospects.

Description

A kind of for Chinese medicine preparation treating autoimmune liver disease and preparation method thereof

Technical field

The present invention relates to a kind of Chinese medicine preparation, be specifically related to a kind of Chinese medicine preparation for treating autoimmune liver disease, the preparation method that the invention still further relates to this Chinese medicine preparation。

Background technology

Autoimmune liver disease is the chronic progressive external inflammation disease mediated by autoimmune response, its Clinical symptoms is serum transaminase rising in various degree, hypergammaglobulinemia, autoantibodies, histologic characteristics is that several cases can rapid progress be liver cirrhosis and liver failure based on the interface characteristics hepatitis of lymphocyte, plasmocyte infiltrating。

Chinese medicine is thought, primary disease belongs to the categories such as " hypochondriac pain ", " jaundice " " melancholia " " asthenia " of the traditional Chinese medical science。Think that its etiology and pathogenesis can be summarized as wet, malicious, empty, the stasis of blood four broad aspect at present more。Patient's ferritic virtual loss diseases caused by exogenous pathogenic factor epidemic disease in addition poison, disorder of emotion, cause the liver failing to maintain the normal flow of QI, dysfunction of the spleen in transportation, and caused by liver and kidney deficiency, gradually to the card of obstruction of collaterals by blood stasis。

At present, autoimmune liver disease there is no specific short。Alone prednisone or prednisone and azathioprine conjoint therapy etc. have certain curative effect。But the long-term or short time uses these medicines to treat, hirsutism, edema, Nausea and vomiting, dizziness, constipation etc. series of side effects symptom can be caused, and the dependency that medicine created, after drug withdrawal, primary affection knock-on increases the weight of the side effect with secondary, patient can be made to produce very big misery, therapeutic process again and again, DeGrain, expense is high, causes bigger pressure at heart and ailing pressure to patient。

Summary of the invention

It is an object of the invention to provide a kind of Chinese medicine preparation for treating autoimmune liver disease, it is notable that this Chinese medicine preparation has therapeutic effect for treatment autoimmune liver disease, and healing time is short, cheap, and have no adverse reaction the feature with secondary toxic action。

Inventor in clinical treatment for many years is put into practice, the law of development according to this disease, and the combination principle of Chinese medicine, and by substantial amounts of clinical verification, Exploration and conclusion goes out the new formula of the Chinese medicine preparation for treating autoimmune liver disease repeatedly。It is notable that the present invention has therapeutic effect, and healing time is short, cheap, and have no adverse reaction the feature with secondary toxic action。

The effect of Chinese medicine of the present invention:

Wherein:

Radix Pseudostellariae: for pinkwort Radix Ginseng Pseudostellariaheterophylla(Miq.) dried root of PaxexPaxetHoffm.。Nature and flavor: hardship sweet, micro-are flat。Return spleen, lung meridian。Effect: replenishing QI to invigorate the spleen, promoting the production of body fluid for nourishing the lung。Tired for insufficiency of the spleen body, inappetence, weak after being ill, deficiency of both vital energy and Yin, spontaneous perspiration is thirsty, dryness of the lung dry cough。" Shaanxi Chinese herbal medicine " is recorded: invigorating qi and benefiting blood, spleen invigorating is promoted the production of body fluid。After curing the disease, body is empty, cough due to deficiency of the lung, insufficiency of the spleen diarrhoea, children's's sweating due to debility, cardiopalmus, xerostomia, anorexia。

Radix Paeoniae Alba (parched): for the processed product of the dry root of ranunculaceae plant Radix Paeoniae PaeonialactifloraPall.。Nature and flavor: bitter, sour, are slightly cold。Return liver, spleen channel。Effect: suppressing the hyperactive liver pain relieving, nourishing blood for regulating menstruation, astringing YIN to stop sweating。For dizziness of having a headache, hypochondriac pain, stomachache, limb pain twin, blood deficiency and yellow complexion, menoxenia, spontaneous perspiration, night sweat。Recording in " herbal classic ": main pathogen is suffered from abdominal pain, except arthralgia due to stagnation of blood, broken heavily fortified point is long-pending, controls cold and heat hernia abdominal mass, pain relieving, diuresis, QI invigorating。

Rhizoma Atractylodis Macrocephalae (parched): for the processed product of the dry rhizome of feverfew Rhizoma Atractylodis Macrocephalae AtractylodesmacrocephalaKoidz.。Nature and flavor: bitter, sweet, temperature。Return spleen, stomach warp。Effect: invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis, antiabortive。For insufficiency of the spleen lack of appetite, abdominal distention is had loose bowels, phlegm retention vertigo and palpitation, edema, spontaneous perspiration, frequent fetal movement。Rhizoma Atractylodis Macrocephalae spleen invigorating, stomach function regulating, antiabortive。For insufficiency of the spleen lack of appetite, loose stool of having loose bowels, frequent fetal movement。" herbal classic " is recorded: main anemofrigid-damp arthralgia, dead flesh, convulsion, subcutaneous ulcer, hidroschesis, heat extraction helps digestion。

Semen Coicis (parched): for grass Semen Coicis Coixlacryma-jobiL.var.ma-yuen(Roman.) the dry mature kernal processed product of Stapf。Nature and flavor: sweet, light are cool。Return spleen, stomach, lung meridian。Effect: spleen invigorating eliminating dampness by diuresis, eliminating impediment antidiarrheal, row is dense in heat clearing away。For edema, beriberi, dysuria, arthralgia chiefly caused by damp pathogen contracture, diarrhea due to hypofunction of the spleen, lung abscess, acute appendicitis；Verruca plana。" detailed outline " is recorded: invigorating spleen and reinforcing stomach, tonifying the lung heat clearing away, remove wind prevailing over dampness。Cook a meal food, control cold air；Decoct drink, diuresis pyretic stranguria。

Radix Astragali Preparata: for leguminous plant Radix Astagali Astragalusmembranaceus(Fisch.) Bge.var.mongholicus(Bge.) Hsiao or Radix Astragali Astragalusmembranaceus(Fisch.) the dry root processed product of Bge.。Nature and flavor: sweet, temperature。Return lung, spleen channel。Effect: invigorating QI to consolidate the body surface resistance, diuresis poison holding, evacuation of pus, expelling pus and promoting granulation。Weak for the deficiency of vital energy, anorexia and loose stool, sinking of QI of middle-JIAO, chronic diarrhea proctoptosis, metrorrhagia of having blood in stool, exterior deficiency spontaneous perspiration, deficiency of vital energy edema, carbuncle difficulty is burst, and bursts for a long time and does not hold back, and blood deficiency dull yellowish colored skin, interior-heat is quenched one's thirst；Chronic nephritis proteinuria, diabetes。

Radix Saposhnikoviae: for umbelliferae Saposhnikovia divaricata Saposhnikoviadivaricata(Turcz.) dry root of Schischk.。Nature and flavor: acrid, sweet, warm。Return bladder, liver, spleen channel。Effect: inducing diaphoresis to dispel wind, victory is wet, relieving convulsion。For headache due to common cold, rheumatic arthralgia, rubella pruritus, tetanus。Recording in " not Lu ": hypochondriac pain, side of body public attention face is gone, extremity contraction urgency, convulsion in word milk gold skin ulcer。

Herba Agrimoniae: for the dry aerial parts of rosaceous plant Radix Agrimoniae AgrimoniapilosaLedeb.。Nature and flavor: bitter, puckery are flat。GUIXIN, Liver Channel。Effect: astringing to arrest bleeding, preventing the attack (or recurrence) of malaria, dysentery relieving, removing toxic substances。For hemoptysis, spit blood, metrostaxis, malaria, dysentery, de-power impairment caused by overstrain, carbuncle sore tumefacting virus, pudendal pruritus leukorrhagia。" BAICAO mirror ": the therapeutic method to keep the adverse QI flowing downwards is invigorated blood circulation, manages all kinds of diseases and ailments, dissipates feeling of fullness；Fall and flutter haematemesis, metrorrhagia, dysentery, discharging fresh blood stool。

Pericarpium Citri Reticulatae: for the dry mature skin of rutaceae orange CitrusreticulataBlanco and variety thereof。Nature and flavor: bitter, pungent, temperature。Return lung, spleen channel。Effect: regulating qi-flowing for strengthening spleen, drying dampness to eliminate phlegm。For fullness in the epigastrium and chest, lack of appetite and vomiting, cough with copious phlegm。

The Rhizoma Pinelliae: for aroid Rhizoma Pinelliae Pinelliaternata(Thunb.) dry tuber of Breit.。Nature and flavor: pungent, temperature；Poisonous。Return spleen, stomach, lung meridian。Effect: drying dampness to eliminate phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, dissolving lump and resolving mass。For abundant expectoration cough with asthma, phlegm retention vertigo and palpitation, dizziness due to wind-phlegm, syncope due to accumulation of phlegm is had a headache, and vomits regurgitation, and breast gastral cavity painful abdominal mass is vexed, globus hystericus；Raw with external treatment carbuncle sucutaneous nodule。Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) is used for stopping nausea and vomiting by lowering the adverse flow of QI。

Rhizoma Zingiberis: for the dry rhizome of zingiber ZingiberofficinaleRosc.。Nature and flavor: pungent, hot。Return spleen, stomach, kidney, the heart, lung meridian。Effect: Rhizoma Zingiberis warming spleen and stomach for dispelling cold, recuperating depleted YANG is promoted blood circulation, dampness expectorant。For coldness and pain in the epigastrium, vomiting is had loose bowels, and cold extremities faint pulse, phlegm retention is breathed with cough。" detailed outline " is recorded: Rhizoma Zingiberis, can draw that blood medicine enters blood system, gas medicine enters edema caused by disorder of QI。Can go again to dislike to support newly, have the meaning of Yin grows while yang is generating。

Radix Angelicae Sinensis: for umbelliferae angelica Angelicasinensis(Oliv.) dry root of Diels。Nature and flavor: sweet, acrid, warm。Return liver, the heart, spleen channel。Effect: replenishing and activating blood, menstruction regulating and pain relieving, loosening bowel to relieve constipation。For blood deficiency and yellow complexion, dizziness cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, dryness of the intestine constipation, rheumatic arthralgia, injury from falling down, ulcer sores。Radix Angelicae Sinensis (processed with wine) promoting blood circulation to restore menstrual flow。For amenorrhea dysmenorrhea, rheumatic arthralgia, injury from falling down。Recording in " not Lu ": warming middle-JIAO to relieve pain, except plug, middle puerperal tetanus, no sweating, arthralgia chiefly caused by damp pathogen in visitor's blood, attacked by pestiferous factors is courteous, cold caused by deficiency, mends five Tibetan, granulation promoting meat。

Poria: for On Polyporaceae Poria Poriacocos(Schw.) dry sclerotia of Wolf。Nature and flavor: sweet, light are flat。GUIXIN, lung, spleen, kidney channel。Effect: promoting diuresis to eliminate damp pathogen, spleen invigorating mind calming。For edema oliguria, phlegm retention vertigo and palpitation, insufficiency of the spleen lack of appetite, have loose bowels in loose stool, irritability, palpitation with fear insomnia。Recording in " property of medicine opinion ": appetizing, preventing or arresting vomiting is inverse, kind tranquilizing mind。Main consumptive lung disease expectorant is stopped up。

Ramulus Cinnamomi: for the dry twig of canella Cortex Cinnamomi CinnamomumcassiaPresl。Spring, season in summer two gather, and remove leaf, dry, or section is dried。Nature and flavor: acrid, sweet, warm。GUIXIN, lung, bladder warp。Cure mainly diaphoresis expelling pathogenic factors from muscles, promoting the flow of QI-blood by warming the meridian, supporing yang activating QI, the flat gas that spins。For anemofrigid cold, coldness and pain in the epigastrium, cold in blood amenorrhea, arthralgia, phlegm retention, edema, cardiopalmus, renal mass。

Herba Lysimachiae: for the dry herb of Ofthe Primulaceae Lysimachia christinae Hance LysimachiachristinaeHance。Nature and flavor: sweet, salty, are slightly cold。Return liver, gallbladder, kidney, bladder warp。Effect: eliminating damp-heat, treating stranguria, detumescence。For pyretic stranguria, Sha Lin, urinate and puckery have a pain, jaundice dark coloured urine, carbuncle furuncle, venom；Liver and bile stone, lithangiuria。" Traditional Chinese Medicine in Sichuan will " is recorded: dispelling the wind and dampness pathogens is numb, bones and muscles pain, jaundice, lung abscess。

Herba Artemisiae Scopariae: for the dry aerial parts of feverfew Artemisia scoparia Waldst. et Kit. ArtemisiascopariaWaldst.etKit. or Herba Artemisiae Scopariae ArtemisiacapillarisThunb.。Nature and flavor: bitter, pungent, are slightly cold。Return spleen, stomach, liver, gallbladder meridian。Effect: clearing away damp-heat, jaundice eliminating subcutaneous ulcer。For jaundice oliguria, eczema pruritus；Infectious jaundice type hepatitis。

Rhizoma Alismatis: for Notes On Alism At Aceae Rhizoma Alismatis Alismaorientalis(Sam.) dry tuber of Juzep.。Nature and flavor: sweet, cold。Return kidney, bladder warp。Effect: diuresis, clearing away damp-heat。For dysuria, edema distension, oliguria of having loose bowels, dizziness due to fluid-retention, the puckery pain of pyretic stranguria；Hyperlipidemia。Recording in " herbal classic ": main anemofrigid-damp arthralgia, breast is difficult, and disappear water, foster the five internal organs, and physical strength profiting is fertile strong。

Fructus Akebiae: for the seed of plants of Lardizabalaceae Caulis Akebiae, threeleaf akebia and Caulis Akebiae。Effect: control a wind cutting, mends five kinds of strain and seven kinds of impairment。Controlling Xuan tinea, air parcel, sky row temperature disease, disappear dyspepsia, and only unhappiness, diuresis, expedite the emergence of, and solves poison of drug, attacked by pestiferous factors aphonia, deals with, and all Serpentiss deposited, worm, silkworm sting。" medical center bun is wanted " is recorded: hard the kidney invigorating water, consumptive fever can be controlled, ward off Serpentis, insect poison。

Radix Curcumae: for the dried root of zingiberaceous plant RADIX CURCUMAE CurcumawenyujinY.H.ChenetC.Ling, Rhizoma Curcumae Longae CurcumalongaL., Guangxi zedoary CurcumakwangsiensisS.G.LeeetC.F.Liang or Rhizoma Curcumae CurcumaphaeocaulisVal.。Nature and flavor: pungent, bitter, cold。Return liver, the heart, lung meridian。Effect: regulating qi to disperse stagnation, heart fire-clearing upset-relieving, promoting the function of the gallbladder to alleviate jaundice。For amenorrhea dysmenorrhea, chest and abdomen swelling and pain, twinge, calentura coma, epilepsy is gone mad, jaundice dark coloured urine。Essentials of Matea Medica is recorded: " circulation of qi promoting, resolving depression；Let out blood, removing blood stasis with potent drugs。Cool heat in the heart, dissipates stagnation of liver-QI。

Fructus Tribuli: for the fruit of zygophyllaceae plant Fructus Tribuli。Nature and flavor: toil, temperature。Return liver, lung meridian。Effect: dissipate wind, improving eyesight, the therapeutic method to keep the adverse QI flowing downwards, promoting the circulation of blood。Controlling headache, itching over the body, conjunctival congestion swells nebula, fullness in the chest, cough with dyspnea, lump in the abdomen, and breast is difficult, carbuncle, scrofula。" not Lu " be recorded: main health pruritus due to wind pathogen, headache, cough with dyspnea impairing the lung, consumptive lung disease, only tired, the therapeutic method to keep the adverse QI flowing downwards；Children's's head sore, carbuncle the moon Huang, can rub powder。

Endothelium Corneum Gigeriae Galli: for the dry inner wall of sandbag of Phasianidae animal man chicken GallusgallusdomesticusBrisson。Vinegar Endothelium Corneum Gigeriae Galli: take clean Endothelium Corneum Gigeriae Galli, fries to heaving according to frying method (appendix II D), sprays vinegar, take out, dry。Every 100kg Endothelium Corneum Gigeriae Galli, uses vinegar 15kg。Nature and flavor: sweet are flat。Return spleen, stomach, small intestinal, bladder warp。Effect: invigorating the stomach and promoting digestion, arresting seminal emission。Do not disappear for food stagnation, vomiting dysentery, infantile malnutrition, the enuresis, seminal emission。" the southern regions of the Yunnan Province book on Chinese herbal medicine " is recorded: " alleviating distention in middle-JIAO spleen invigorating, help digestion mill stomach。Controlling children's's breast food knot stagnant, the big muscle of tripe is blue or green, mass in the abdomen infantile malnutrition。

Fructus Toosendan: for the dry mature fruit of Meliaceae plant Fructus Toosendan MeliatoosendanSieb.etZucc.。Nature and flavor: bitter, cold；Slightly poisonous。Return liver, small intestinal, bladder warp。Effect: soothing liver-QI promoting the circulation of QI to relieve pain, anthelmintic。For the breast side of body, abdominal distention, colic, abdominal pain due to worm stagnation。" medical center bun is wanted " is recorded: eliminating heart-fire, hard kidney water, lung heat clearing gold, clearing away liver-fire。Core: happy hernia, removes syndrome of aversion to cold lasting day and night with cold limbs。

Rhizoma Corydalis: for the dry tuber of papaveraceae plant corydalis CorydalisyanhusuoW.T.Wang。Nature and flavor: pungent, bitter, temperature。Return liver, spleen channel。Effect: invigorate blood circulation, promoting the circulation of QI, pain relieving。For the breast side of body, epigastric pain, amenorrhea dysmenorrhea, postpartum stagnation, tumbling and swelling。Recording in " Japan hanako materia medica ": except wind, control gas, warm waist knee joint, broken disease addiction, flutter damage blood stasis, fall tire, and sudden and violent lumbago。

Radix Rehmanniae: for the fresh of scrophulariaceae rehmannia glutinosa plant RehmanniaglutinosaLibosch. or dried root。Radix Rehmanniae: sweet, cold。GUIXIN, liver, kidney channel。Effect: clearing away heat and cooling blood, yin nourishing, promote the production of body fluid。For calentura crimson tongue excessive thirst, yin asthenia generating intrinsic heat, hectic fever due to YIN-deficiency consumptive fever, interior-heat is quenched one's thirst, and spits blood, and epistaxis sends out speckle dermexanthesis。

Fructus Gardeniae (parched): for the dry mature fruit processed product of Maguireothamnus speciosus Fructus Gardeniae GardeniajasminoidesEllis。Nature and flavor: bitter, cold。GUIXIN, lung, tri-jiao channel。Function cures mainly: fruit: pathogenic fire purging relieving restlessness, clearing away heat and promoting diuresis, removing pathogenic heat from blood and toxic substance from the body。Vexed for calentura, jaundice dark coloured urine, blood strangury and dry pain, heat in blood tells nosebleed, conjunctival congestion and swelling pain, pathogenic fire,toxin and furuncles；External treatment bruise pain。" not Lu " be recorded: treat order heat also pain, the big heat of the breast heart, intestine and small intestine, unhappy in the heart, pathogenic heat in the stomach gas。

Fructus Jujubae: for Rhamnaceae jujube Fructus Jujubae ZiziphusjujubaMill.var.inermis(Bunge) dry mature fruit of Rehd.。Nature and flavor: sweet, temperature。Return spleen, stomach warp。Effect: invigorating the spleen and replenishing QI, nourishing blood to tranquillize the mind。For insufficiency of the spleen lack of appetite, weak loose stool, woman hysteria。Recording in " not Lu ": invigorating the spleen and replenishing QI, powerful, relieving restlessness is vexed, treats under the heart outstanding, and intestinal is out-of-the-way。

Radix Glycyrrhizae: for the dry root of glycyrrhizic legume GlycyrrhizauralensisFisch., Glycyrrhiza inflata Bat. GlycyrrhizainflataBat. or Glycyrrhiza glabra L. GlycyrrhizaglabraL.。Nature and flavor: sweet are flat。GUIXIN, lung, spleen, stomach warp。Function cures mainly: invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription。For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, gastral cavity abdomen, extremity contraction urgency pain, carbuncle sore tumefacting virus, cushion toxicity, strong。" illustrated handbook planted by middle traditional Chinese medicines " is recorded: control peptic ulcer and jaundice。

The square solution of the present invention is: Radix Paeoniae Alba (parched) suppressing the hyperactive liver pain relieving, nourishing blood for regulating menstruation, Radix Astragali Preparata invigorating QI to consolidate the body surface resistance, diuresis poison holding, Rhizoma Zingiberis warming spleen and stomach for dispelling cold, recuperating depleted YANG are promoted blood circulation, dampness expectorant, and Chinese angelica blood supplementing is invigorated blood circulation, menstruction regulating and pain relieving, Ramulus Cinnamomi promoting the flow of QI-blood by warming the meridian, supporing yang activating QI, Fructus Toosendan soothing liver-QI circulation of qi promoting, pain relieving anthelmintic, Radix Rehmanniae clearing away heat and cooling blood, YIN nourishing and the production of body fluid promoting, Fructus Jujubae invigorating the spleen and replenishing QI, nourishing blood to tranquillize the mind, above eight taste medicines are as monarch drug in side, all return Liver Channel, there is the QI invigorating that nourishes blood, effect that warming the meridian is supporing yang。According to theory of Chinese medical science, adolescence kidney qi is not filled；Menopause kidney qi degradation, so endogenous cause of ill is mainly innate deficiency, kidney qi virtual loss and cause primary disease。So nourishing blood QI invigorating, warming the meridian is supporing yang is the basis for the treatment of autoimmune liver disease, above eight taste medicines are monarch drug, and the QI invigorating that first fundamentally nourishes blood, warming the meridian is supporing yang, makes disease obtain basic control。Radix Pseudostellariae replenishing QI to invigorate the spleen, promoting the production of body fluid for nourishing the lung, Rhizoma Atractylodis Macrocephalae (parched) invigorating the spleen and benefiting QI, dampness diuretic, Semen Coicis (parched) spleen invigorating eliminating dampness by diuresis, eliminating impediment antidiarrheal, Pericarpium Citri Reticulatae regulating qi-flowing for strengthening spleen, drying dampness to eliminate phlegm, Rhizoma Pinelliae drying dampness to eliminate phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, Poria promoting diuresis to eliminate damp pathogen, spleen invigorating mind calming, vinegar Endothelium Corneum Gigeriae Galli invigorating the stomach and promoting digestion, arresting seminal emission, Rhizoma Corydalis is invigorated blood circulation promoting the circulation of QI, pain relieving circulation of qi promoting, ministerial drug in the above eight taste medicine sides of being, the traditional Chinese medical science thinks that primary disease is outer because of being invaded by exogenous pathogen, especially wind heat pathogenic factor in the exterior, wind heat is YANG pathogen, easily consumption Tianjin impairment of YIN；This disease female patient is in the majority again, and according to feminine characteristics, many melancholys are sentimental, is easily hindered by " seven emotions ", " married woman kind bosom and how strongly fragrant ", causes feelings will uncomfortable, stagnation of QI due to depression of the liver, and strongly fragrant heat-transformation of a specified duration can increase the weight of the pathological change of the deficiency of YIN further。As ministerial drug in side, auxiliary monarch drug nourishes blood QI invigorating, effect that warming the meridian is supporing yang on the one hand；There is effect of the spleen strengthening and damp drying, activating QI to eliminate phlegm on the other hand as ministerial drug。Radix Saposhnikoviae inducing diaphoresis to dispel wind, the wet relieving convulsion of victory, Herba Agrimoniae astringing to arrest bleeding, preventing the attack (or recurrence) of malaria detoxifies, Herba Lysimachiae eliminating damp-heat, treating stranguria detumescence, Herba Artemisiae Scopariae clearing away damp-heat, jaundice eliminating subcutaneous ulcer, Rhizoma Alismatis diuresis, clearing away damp-heat, Fructus Akebiae diuresis, solve poison of drug, Radix Curcumae regulating qi to disperse stagnation, heart fire-clearing upset-relieving, Fructus Tribuli dissipates wind improving eyesight, therapeutic method to keep the adverse QI flowing downwards promoting the circulation of blood, Fructus Gardeniae (parched) clearing away heat and promoting diuresis, removing pathogenic heat from blood and toxic substance from the body, above nine taste medicines are as adjuvant drug, from pathology, treatment causes the inducement of autoimmune liver disease, the QI invigorating that nourishes blood of the monarch and his subjects two medicine can be promoted as adjuvant drug, effect that warming the meridian is supporing yang, body the spleen strengthening and damp drying can be promoted by using corrigent the monarch and his subjects two medicine again, the effect of activating QI to eliminate phlegm。Simultaneously as the effect with heat-clearing and toxic substances removing。Radix Glycyrrhizae, as making medicine in side, has coordinating the actions of various ingredients in a prescription, is in harmonious proportion the effect of flavour of a drug, and all medicines of this side share, and the monarch and his subjects pull together, and help and make auxiliary altogether, has the QI invigorating that nourishes blood, warming the meridian is supporing yang, effect of the spleen strengthening and damp drying, activating QI to eliminate phlegm, it is possible to effectively treat autoimmune liver disease。

Another important feature of the present invention is that this Chinese medicine preparation contains abundant nutritional labeling, more than 17 kinds are had rich in aminoacid, wherein essential amino acid has threonine, valine, methionine, isoleucine, leucine, lysine and phenylalanine, trace element containing needed by human has ferrum, chromium, copper, boron, manganese, strontium and zinc, several human body macroelement of another calcic, potassium, magnesium, phosphorus。Above nutritional labeling is all needed by human material, can effectively strengthen body immunity。

Medicine material consumption of the present invention is groped to sum up to draw through inventor in a large number, each raw material dosage is for all to have good curative effect in following weight parts scope: Radix Pseudostellariae 4-8 part, Radix Paeoniae Alba (parched) 13-17 part, Rhizoma Atractylodis Macrocephalae (parched) 16-20 part, Semen Coicis (parched) 16-20 part, Radix Astragali Preparata 28-32 part, Radix Saposhnikoviae 7-11 part, Herba Agrimoniae 22-26 part, Pericarpium Citri Reticulatae 10-14 part, Rhizoma Pinelliae 7-11 part, Rhizoma Zingiberis 13-17 part, Radix Angelicae Sinensis 16-20 part, Poria 13-17 part, Ramulus Cinnamomi 13-17 part, Herba Lysimachiae 22-26 part, Herba Artemisiae Scopariae 22-26 part, Rhizoma Alismatis 16-20 part, Fructus Akebiae 13-17 part, Radix Curcumae 10-14 part, Fructus Tribuli 16-20 part, vinegar Endothelium Corneum Gigeriae Galli 10-14 part, Fructus Toosendan 13-17 part, Rhizoma Corydalis 10-14 part, Radix Rehmanniae 16-20 part, Fructus Gardeniae (parched) 10-14 part, Fructus Jujubae 7-11 part, Radix Glycyrrhizae 4-8 part。

Wherein it is preferably: Radix Pseudostellariae 6 parts, Radix Paeoniae Alba (parched) 15 parts, Rhizoma Atractylodis Macrocephalae (parched) 18 parts, Semen Coicis (parched) 20 parts, Radix Astragali Preparata 30 parts, Radix Saposhnikoviae 9 parts, Herba Agrimoniae 24 parts, Pericarpium Citri Reticulatae 12 parts, the Rhizoma Pinelliae 9 parts, Rhizoma Zingiberis 15 parts, Radix Angelicae Sinensis 18 parts, 15 parts of Poria, Ramulus Cinnamomi 15 parts, Herba Lysimachiae 24 parts, Herba Artemisiae Scopariae 24 parts, Rhizoma Alismatis 18 parts, Fructus Akebiae 15 parts, Radix Curcumae 12 parts, Fructus Tribuli 18 parts, vinegar Endothelium Corneum Gigeriae Galli 12 parts, Fructus Toosendan 15 parts, Rhizoma Corydalis 12 parts, Radix Rehmanniae 18 parts, Fructus Gardeniae (parched) 12 parts, 9 parts of Fructus Jujubae, Radix Glycyrrhizae 6 parts。

The preparation method of a kind of Chinese medicine preparation for treating autoimmune liver disease is as follows:

Step one: by weight of the present invention, takes Radix Paeoniae Alba (parched), Rhizoma Atractylodis Macrocephalae (parched), Semen Coicis (parched), Radix Astragali Preparata, vinegar Endothelium Corneum Gigeriae Galli, Fructus Gardeniae (parched), pulverizes, and crosses 200 mesh sieves, standby；

Step 2: by weight of the present invention, takes the Rhizoma Pinelliae, Fructus Toosendan medical material is placed in marmite, adds the water of 3 times of volumes, intense fire infusion 20-30 minute, fire infusion 30-40 minute of larding speech with literary allusions, and filter liquor, repeatedly infusion three times merge three filtrates, standby；

Step 3: by weight proportion of the present invention, take Radix Pseudostellariae, Radix Saposhnikoviae, Rhizoma Zingiberis, Radix Curcumae, Fructus Tribuli, Rhizoma Corydalis, Radix Rehmanniae medical material are placed in marmite, add the water of 8 times of volumes, after intense fire infusion 20-30 minute, adding Herba Agrimoniae, Pericarpium Citri Reticulatae, Radix Angelicae Sinensis, Poria, Ramulus Cinnamomi, Herba Lysimachiae, Herba Artemisiae Scopariae, Rhizoma Alismatis, Fructus Jujubae, Radix Glycyrrhizae and the Fructus Akebiae tied respectively, intense fire infusion 10-20 minute with bundle, fire infusion of larding speech with literary allusions obtains filtrate in 30 ~ 40 minutes, infusion merges gained filtrate for three times repeatedly, standby；

Step 4: combining step two, step 3 gained filtrate and with step one gained powder, mixing, stir evenly, both the decoction for the treatment of autoimmune liver disease of the present invention。

Using method of the present invention: take decoction, take in meal one hour after, every day three times。

Medicine of the present invention has the QI invigorating that nourishes blood, warming the meridian is supporing yang, the effect of the spleen strengthening and damp drying, activating QI to eliminate phlegm, and good analgesic effect, cheap, having no side effect, easy to use, the mode that this Chinese medicine preparation adopts treats the injury that can reduce Western medicine to patient body, alleviate the slight illness of patient, according to clinical 60 example patient view statistics, use medicine of the present invention the total effective rate course for the treatment of 83.3%, two the course for the treatment of total effective rate 93.4%。

Detailed description of the invention

Embodiment one: Radix Pseudostellariae 6 parts, Radix Paeoniae Alba (parched) 15 parts, Rhizoma Atractylodis Macrocephalae (parched) 18 parts, Semen Coicis (parched) 20 parts, Radix Astragali Preparata 30 parts, Radix Saposhnikoviae 9 parts, Herba Agrimoniae 24 parts, Pericarpium Citri Reticulatae 12 parts, the Rhizoma Pinelliae 9 parts, Rhizoma Zingiberis 15 parts, Radix Angelicae Sinensis 18 parts, 15 parts of Poria, Ramulus Cinnamomi 15 parts, Herba Lysimachiae 24 parts, Herba Artemisiae Scopariae 24 parts, Rhizoma Alismatis 18 parts, Fructus Akebiae 15 parts, Radix Curcumae 12 parts, Fructus Tribuli 18 parts, vinegar Endothelium Corneum Gigeriae Galli 12 parts, Fructus Toosendan 15 parts, Rhizoma Corydalis 12 parts, Radix Rehmanniae 18 parts, Fructus Gardeniae (parched) 12 parts, 9 parts of Fructus Jujubae, Radix Glycyrrhizae 6 parts。

Embodiment two: Radix Pseudostellariae 7 parts, Radix Paeoniae Alba (parched) 14 parts, Rhizoma Atractylodis Macrocephalae (parched) 17 parts, Semen Coicis (parched) 21 parts, Radix Astragali Preparata 31 parts, Radix Saposhnikoviae 7 parts, Herba Agrimoniae 26 parts, Pericarpium Citri Reticulatae 11 parts, the Rhizoma Pinelliae 8 parts, Rhizoma Zingiberis 14 parts, Radix Angelicae Sinensis 17 parts, 15 parts of Poria, Ramulus Cinnamomi 14 parts, Herba Lysimachiae 23 parts, Herba Artemisiae Scopariae 23 parts, Rhizoma Alismatis 18 parts, Fructus Akebiae 14 parts, Radix Curcumae 12 parts, Fructus Tribuli 18 parts, vinegar Endothelium Corneum Gigeriae Galli 13 parts, Fructus Toosendan 14 parts, Rhizoma Corydalis 11 parts, Radix Rehmanniae 17 parts, Fructus Gardeniae (parched) 11 parts, 7 parts of Fructus Jujubae, Radix Glycyrrhizae 7 parts。

Embodiment three: Radix Pseudostellariae 8 parts, Radix Paeoniae Alba (parched) 14 parts, Rhizoma Atractylodis Macrocephalae (parched) 19 parts, Semen Coicis (parched) 21 parts, Radix Astragali Preparata 31 parts, Radix Saposhnikoviae 8 parts, Herba Agrimoniae 23 parts, Pericarpium Citri Reticulatae 11 parts, the Rhizoma Pinelliae 10 parts, Rhizoma Zingiberis 15 parts, Radix Angelicae Sinensis 19 parts, 14 parts of Poria, Ramulus Cinnamomi 14 parts, Herba Lysimachiae 23 parts, Herba Artemisiae Scopariae 23 parts, Rhizoma Alismatis 17 parts, Fructus Akebiae 14 parts, Radix Curcumae 11 parts, Fructus Tribuli 17 parts, vinegar Endothelium Corneum Gigeriae Galli 13 parts, Fructus Toosendan 14 parts, Rhizoma Corydalis 13 parts, Radix Rehmanniae 17 parts, Fructus Gardeniae (parched) 11 parts, 8 parts of Fructus Jujubae, Radix Glycyrrhizae 6 parts。

Patient is presented herein below and uses the clinical statistics data of medicine of the present invention:

One, physical data

Accepting out-patient 60 example for medical treatment, patient is randomly divided into observation group and each 30 examples of matched group, wherein male 10 example, women 50 example, M-F 1:5, max age 58 years old, minimal ages 12 years old, course of disease some months to several years is not etc.。Every basic documents such as two groups of patient ages, sex, courses of disease are essentially identical, no significant difference (P > 0.05)。

Two, diagnostic criteria

1, adolescence and menopausal woman it are apt to occur in；

2, General Symptoms: weak, is short of physical strength, out of spirits。

3, symptom of digestive tract: inappetence, detest oil, feel sick, abdominal distention。

4, show outside liver: face is dark and gloomy or pitch-dark, spider angioma, male erectile dysfunction, and cyclomastopathy swells and ache, female menstrual disorder, amenorrhea, hyposexuality。

5, hepatalgia: hepatitis patient usually tells pain in the hepatic region, relates to upper right abdomen or right back, and pain degree differs, some distending pains, dull pain or prickling-like pain, aggravation time movable, and the time differs；Sometimes pain relief during left lateral position。

Three, Therapeutic Method:

1, observation group is according to Medications Example one of the present invention, and weighting raw materials, by the treatment of invention implementation, takes decoction, takes in meal one hour after, every day three times。It within 7 days, it is a course for the treatment of。

2, matched group adopts conventional western medicine prednisone and the treatment of azathioprine conjoint therapy, within 7 days, is a course for the treatment of。

Four, efficacy assessment standard:

1, cure: clinical symptoms all disappears, it does not have leave any sequela。2, take a turn for the better: hepatalgia, inappetence, feel sick etc. transference cure, malaise symptom out of spirits occurs once in a while。3, invalid: through treating more than 1 week, symptom is not all felt any better person。

Five, therapeutic outcome statistics:

Matched group result is added up

Use the Comparison of therapeutic situation of this Chinese medicine preparation two courses for the treatment of of two groups of patients

Wherein: total effective rate=cure rate+improvement rate

By contrasting the treatment total effective rate of two groups of patients it appeared that observation group is apparently higher than matched group, thus illustrate, Chinese medicine of the present invention has good clinical effectiveness on treatment autoimmune liver disease, the cure rate for the treatment of can be effectively improved, effect is notable, cheap, have no adverse reaction and any toxic and side effects, there is wide market application foreground。

Model case and curative effect:

Case one, patient Wang, female, 15 years old, people from Qingdao City, comes here and goes to a doctor on January 20th, 2010。Main suit: weak, is short of physical strength, out of spirits, inappetence, nauseating, pain in the hepatic region, relate to upper right abdomen or right back, going examination in hospital diagnosis is autoimmune liver disease。Through treatment pain relief, but do not cure。Occurring again symptom before ten days, then here treatment, adopt made preparation in the embodiment of the present invention one and selected preparation method, after medication 5 days, pain disappears, and recovers good, continues medication 6 days, and symptom all thoroughly disappears, and Effect of follow-up visit by telephone does not recur half a year。

Case two, patient Lee, female, 53 years old, people from Linyi, Shandong。Coming here on May 14th, 2010 to go to a doctor, symptom is as follows after diagnosing: malaise, out of spirits。Inappetence, detesting oil, abdominal distention, face is dark and gloomy or pitch-dark, spider angioma, and cyclomastopathy swells and ache, pain in the hepatic region, relates to right back, and pain degree differs, and time movable, aggravation, is diagnosed as autoimmune liver disease。Adopting made preparation in the embodiment of the present invention one and selected preparation method, symptom goes down, and pain slightly alleviates, and after medication 7 days, pain disappears, and affected part recovers good, continues medication 5 days, thoroughly cures, and Effect of follow-up visit by telephone does not recur half a year。

Claims (4)

1. the Chinese medicine preparation being used for treating autoimmune liver disease, it is characterized in that, this Chinese medicine preparation is made up of the medicine of following weight portion: Radix Pseudostellariae 4-8 part, Radix Paeoniae Alba (parched) 13-17 part, Rhizoma Atractylodis Macrocephalae (parched) 16-20 part, Semen Coicis (parched) 16-20 part, Radix Astragali Preparata 28-32 part, Radix Saposhnikoviae 7-11 part, Herba Agrimoniae 22-26 part, Pericarpium Citri Reticulatae 10-14 part, Rhizoma Pinelliae 7-11 part, Rhizoma Zingiberis 13-17 part, Radix Angelicae Sinensis 16-20 part, Poria 13-17 part, Ramulus Cinnamomi 13-17 part, Herba Lysimachiae 22-26 part, Herba Artemisiae Scopariae 22-26 part, Rhizoma Alismatis 16-20 part, Fructus Akebiae 13-17 part, Radix Curcumae 10-14 part, Fructus Tribuli 16-20 part, vinegar Endothelium Corneum Gigeriae Galli 10-14 part, Fructus Toosendan 13-17 part, Rhizoma Corydalis 10-14 part, Radix Rehmanniae 16-20 part, Fructus Gardeniae (parched) 10-14 part, Fructus Jujubae 7-11 part, Radix Glycyrrhizae 4-8 part。

2. the Chinese medicine preparation for treating autoimmune liver disease according to claim 1, it is characterized in that, it is made up of the medicine of following weight portion: Radix Pseudostellariae 6 parts, Radix Paeoniae Alba (parched) 15 parts, Rhizoma Atractylodis Macrocephalae (parched) 18 parts, Semen Coicis (parched) 20 parts, Radix Astragali Preparata 30 parts, Radix Saposhnikoviae 9 parts, Herba Agrimoniae 24 parts, Pericarpium Citri Reticulatae 12 parts, the Rhizoma Pinelliae 9 parts, Rhizoma Zingiberis 15 parts, Radix Angelicae Sinensis 18 parts, 15 parts of Poria, Ramulus Cinnamomi 15 parts, Herba Lysimachiae 24 parts, Herba Artemisiae Scopariae 24 parts, Rhizoma Alismatis 18 parts, Fructus Akebiae 15 parts, Radix Curcumae 12 parts, Fructus Tribuli 18 parts, vinegar Endothelium Corneum Gigeriae Galli 12 parts, Fructus Toosendan 15 parts, Rhizoma Corydalis 12 parts, Radix Rehmanniae 18 parts, Fructus Gardeniae (parched) 12 parts, 9 parts of Fructus Jujubae, Radix Glycyrrhizae 6 parts。

3. the Chinese medicine preparation for treating autoimmune liver disease according to claim 1 and 2, it is characterised in that: described Chinese medicine preparation is decoction。

4. the preparation method for treating the Chinese medicine preparation of autoimmune liver disease, it is characterised in that preparation method is as follows:

Step one: by weight of the present invention, takes Radix Paeoniae Alba (parched), Rhizoma Atractylodis Macrocephalae (parched), Semen Coicis (parched), Radix Astragali Preparata, vinegar Endothelium Corneum Gigeriae Galli, Fructus Gardeniae (parched), pulverizes, and crosses 200 mesh sieves, standby；

Step 2: by weight of the present invention, takes the Rhizoma Pinelliae, Fructus Toosendan medical material is placed in marmite, adds the water of 3 times of volumes, intense fire infusion 20-30 minute, fire infusion 30-40 minute of larding speech with literary allusions, and filter liquor, repeatedly infusion three times merge three filtrates, standby；

Step 3: by weight proportion of the present invention, take Radix Pseudostellariae, Radix Saposhnikoviae, Rhizoma Zingiberis, Radix Curcumae, Fructus Tribuli, Rhizoma Corydalis, Radix Rehmanniae medical material are placed in marmite, add the water of 8 times of volumes, after intense fire infusion 20-30 minute, adding Herba Agrimoniae, Pericarpium Citri Reticulatae, Radix Angelicae Sinensis, Poria, Ramulus Cinnamomi, Herba Lysimachiae, Herba Artemisiae Scopariae, Rhizoma Alismatis, Fructus Jujubae, Radix Glycyrrhizae and the Fructus Akebiae tied respectively, intense fire infusion 10-20 minute with bundle, fire infusion of larding speech with literary allusions obtains filtrate in 30 ~ 40 minutes, infusion merges gained filtrate for three times repeatedly, standby；

Step 4: combining step two, step 3 gained filtrate and with step one gained powder, mixing, stir evenly, both the decoction for the treatment of autoimmune liver disease of the present invention。