CN106617000A - Traditional Chinese medicinal composition for enhancing immunity and relieving fatigue, as well as preparation method and application of traditional Chinese medicinal composition - Google Patents
Traditional Chinese medicinal composition for enhancing immunity and relieving fatigue, as well as preparation method and application of traditional Chinese medicinal composition Download PDFInfo
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Classifications
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/481—Astragalus (milkvetch)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/254—Acanthopanax or Eleutherococcus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/41—Crassulaceae (Stonecrop family)
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8969—Polygonatum (Solomon's seal)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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- A—HUMAN NECESSITIES
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- A61K2236/50—Methods involving additional extraction steps
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- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
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- Botany (AREA)
- Biotechnology (AREA)
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- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a traditional Chinese medicinal composition for enhancing immunity and relieving fatigue, as well as a preparation method and application of the traditional Chinese medicinal composition. The traditional Chinese medicinal composition for enhancing the immunity and relieving the fatigue comprises the following raw materials in parts by weight: 1 to 6 parts of radix astragali, 2 to 8 parts of rhodiola rosea, 2 to 5 parts of acanthopanax root and 2 to 10 parts of rhizoma polygonati; the invention also discloses the application of a medicinal composition which consists of water and/or alcohol extracts of the raw materials above serving as active ingredients and pharmaceutically acceptable additives in preparation of food, healthcare food or a medicine for improving human immunity and relieving the fatigue. The traditional Chinese medicinal composition for enhancing the immunity and relieving the fatigue, and the preparation method and the application thereof have the beneficial effects that the formula comprises the four traditional Chinese medicinal raw materials, namely, the radix astragali, the rhodiola rosea, the acanthopanax root and the rhizoma polygonati, which can be used as food and medicines; the raw materials which can be used as the food and the medicines can be used as delicious food for eating, and can also be used as medicinal materials for treating diseases; through a plurality of years, even hundreds of years and thousands of years eating, the raw materials which can be used as the food and the medicines are proved to be beneficial and harmless to human bodies, and are suitable for common population to eat for a long time; the four raw materials in the product are environmentally friendly, so that the immunity can be enhanced, the fatigue can be relieved, the safety is high, and adverse actions are avoided.
Description
Technical field
The present invention relates to technical field of traditional Chinese medicines, it particularly relates to a kind of strengthen immunity, the Chinese traditional medicine composition of fatigue-relieving
Thing and its preparation method and application.
Background technology
As modern society people rhythm of life is accelerated, social competition is day by day fierce, and many people Jing often occur under immunity
Drop, respond declines, and adaptability declines, and slightly moves and then feels fatigue, and cannot be relieved after rest, while with appetite not
Shake, have a headache dizzy Halo, easy catching a cold, stress cannot be alleviated, anxiety of having a sleepless night, interpersonal relationships is uncoordinated, social contact ability difference etc.
Performance.Show according to the research of the World Health Organization:The people that 75% is there are about in the whole world is in sub-health state, wherein fatigue
It is the modal form of expression with immunity degradation.When body is in a long time in fatigue state without obtaining timely
Alleviate, a series of physiological acoustic signals will occur in vivo, cause the various functions such as immunity to decline, can also injure when serious
, there are various diseases in internal organs.Therefore, it is badly in need of exploitation with enhance immunity effect, the food of fatigue-relieving, health food or medicine
Product.
Chemicals and biological products such as caffeine, meclofenoxate, Mo Dafeini, amphetamine, Pidotimod, how anti-first
Element, thymopeptide-5 etc. have preferable effect in terms of dispelling fatigue and strengthen immunity, but such medicine is mostly cerebral cortex
Stimulant, by preventing or treating CNS inhibition, so as to play antifatigue effect, but such medicine often has additive, length
Phase takes large side effects, causes clinical practice to limit to.Chinese tradition traditional Chinese medicine is paid attention to transferring the immunity of human body itself, reaches anti-
Fatigue capability, has advantageous advantage, while having peace operating efficiency aspect to antifatigue, strengthen immunity, is improved
Entirely effectively, the characteristics of toxic and side effect is little.The medicine and health products of the strengthen immunity for listing at present, some health products take stopgap measures and do not control
This, while not having anti-fatigue effect, it is impossible to take for a long time, and while has strengthen immunity and function of physical fatigue alleviation
Product can be counted on one's fingers.Therefore, Small side effects, eutherapeutic raising body immunity, the middle medical instrument of fatigue-relieving function are researched and developed
There is huge market development potential.
The content of the invention
For the above-mentioned technical problem in correlation technique, the present invention proposes strengthen immunity, the Chinese traditional medicine composition of fatigue-relieving
Thing and its preparation method and application, to solve above-mentioned technical problem.
To realize above-mentioned technical purpose, the technical scheme is that what is be achieved in that：
The Chinese medicine composition of a kind of strengthen immunity, fatigue-relieving, including the raw material of following parts by weight：It is 1～6 part of the Radix Astragali, red
2～10 parts of 2～8 parts of red-spotted stonecrop, 2～5 parts of wilsonii and sealwort, or by above-mentioned raw materials water and/or alcohol extract as active ingredient
Raising body immunity, fatigue-relieving food, health care are being prepared with the pharmaceutical composition of pharmaceutically acceptable additives composition
Application in food or medicine.
Preferably, including 6～10 parts of 3～5 parts of the Radix Astragali as described below, 4～8 parts of rhodiola root, 3～5 parts of wilsonii and sealwort,
Or the pharmaceutical composition being made up of as active ingredient and pharmaceutically acceptable additives the water and/or alcohol extract of above-mentioned raw materials
Preparing the application improved in body immunity, fatigue-relieving food, health food or medicine.
Preferably, 10 parts of 5 parts of the Radix Astragali, 5 parts of rhodiola root, 5 parts of wilsonii and sealwort, or the water by above-mentioned raw materials and/
Or alcohol extract is preparing raising human immunity as the pharmaceutical composition of active ingredient and pharmaceutically acceptable additives composition
Application in power, fatigue-relieving food, health food or medicine.
The preparation method of a kind of strengthen immunity, the Chinese medicine composition of fatigue-relieving, comprises the steps：
S1, feeding：Take 2～10 parts of 1～6 part of the Radix Astragali, 2～8 parts of rhodiola root, 2～5 parts of wilsonii and sealwort；
The preparation of S2, extract：By above-mentioned raw materials mixing, pulverize and sieve, add water to cook 1-3 acquisition filtrate, 60 DEG C of decompressions of Jing
Dry cream is concentrated into, is crushed, sieved and obtain final product extract；
S3, preparation of preparation：Said extracted thing is taken, the dextrin of 100 mesh sieves was added, is mixed, with the softwood processed of 50% ethanol, cross 16
Mesh nylon mesh, 80 DEG C of dryings, whole grain.
Preferably, it is the water of addition bulk drug gross weight 5-8 times in step S2.
The preparation method of a kind of strengthen immunity, the Chinese medicine composition of fatigue-relieving, comprises the steps：
The preparation of S1, Rhizoma Polygonati extract：Sealwort 2-10 parts, are dried, sieve, and add water to cook 1-3 acquisition filtrate, 60 DEG C of decompressions of Jing
Dry cream is concentrated into, is crushed, sieved and obtain final product Rhizoma Polygonati extract；
The preparation of S2, Astragalus Root P.E：Radix Astragali 1-6 parts, are dried, sieve, and add water to cook 1-3 acquisition filtrate, 60 DEG C of decompressions of Jing
Dry cream is concentrated into, is crushed, sieved and obtain final product Rhizoma Polygonati extract；
The preparation of S3, gadol extract：Rhodiola root 2-8 parts, are dried, sieve, and add water to cook 1-3 acquisition filtrate, 60 DEG C of Jing
Dry cream is evaporated to, is crushed, sieved and obtain final product Rhizoma Polygonati extract；
The preparation of S4, siberian Ginseng P.E：Wilsonii 2-5 parts, are dried, sieve, and add water to cook 1-3 acquisition filtrate, 60 DEG C of Jing
Dry cream is evaporated to, is crushed, sieved and obtain final product Rhizoma Polygonati extract；
The mixing of S5, extract：The extract for taking above-mentioned sealwort, the Radix Astragali, rhodiola root and wilsonii respectively is mixed；
S6, preparation of preparation：The dextrin of 100 mesh sieves was added, was mixed, with 50% ethanol softwood, 16 mesh nylon mesh of mistake, 80 DEG C
It is dried, whole grain.
Preferably, it is the water of addition bulk drug weight 5-8 times in step S1-S4.
The Chinese medicine preparation of a kind of strengthen immunity, fatigue-relieving, including Chinese medicine composition and pharmaceutically acceptable auxiliary material.
Preferably, it is oral formulations, and the oral formulations include pressed candy, tea in bag, instant tea, tablet, capsule
Agent, powder, pill, granule, oral liquid or injection.
A kind of application of strengthen immunity, the Chinese medicine composition of fatigue-relieving, the Chinese medicine composition is exempted from preparation enhancing
Application in epidemic disease power, the food for alleviating organism fatigue, health products or medicine.
The pharmacology of main Chinese medicine material used of the invention is as follows：
Sealwort is the perennial herbal plant sealwort Polygonatum sibiricum Red of Liliaceae, P. kingianum P.kingianum
Coll. the rhizome of et Hemsl or David's-harp P.cyrtonema Hua, with moistening lung enriching yin, tonifying middle-Jiao and Qi, enriching kidney essence
Effect, long term usage macrobiosis of making light of one's life by commiting suicide is hungry.《Compendium of Materia Medica》Think its " obtaining the essence of female soil, be the victory product for taking a tonic or nourishing food to build up one's health Middle Palace ".With benefit
Gas yin-nourishing, invigorating the spleen, moistening lung, the function of kidney-nourishing.For deficiency of spleen-QI and stomach-QI, fatigue and asthenia, deficiency of stomach-Yin, xerophagia is few, deficiency syndrome of the lung cough caused by dryness, labor
Cough hemoptysis, asthenia of essence and blood, soreness and weakness of waist and knees, poliosis, Heat Diabetes.
The Radix Astragali Radix Astragali is legume astragalus mongolicus Mongholicus (Bge.) Hsiao or Astragalus membranacus
The dry root of Astragalus membranaceus (Fisch.) Bge., sweet, tepor.It is loaded in《Sheng Nong's herbal classic》, it is classified as
Product, with tonifying Qi and lifting yang, strengthening exterior and reducing sweat, inducing diuresis for removing edema, blood-nourishing of promoting the production of body fluid, the stagnant logical numbness of row, pus draining and toxin expelling, the effect of expelling pus and promoting granulation,
Clinically it is usually used in treatment deficiency of vital energy weak, anorexia and loose stool, the sinking of qi of middle-jiao, rush down prolapse of the anus for a long time, uterine bleeding of having blood in stool, exterior deficiency spontaneous perspiration, deficiency of vital energy oedema is interior
Heat is quenched one's thirst, blood deficiency chlorosis, hemiplegia, and numbness pain is numb, ulcer is difficult to burst, bursts for a long time and does not holds back.
Rhodiola root is crassulaceae plants rhodiola Rhodiolacrenulata (Hook.f.et Thoms.) H
.Ohba dry root and rhizome.With qi and activate blood circulation, promotes blood circulation and relievings asthma effect.For qi deficiency to blood stasis, chest impediment and cardialgia, hemiplegia,
Burnout is panted., modern pharmacological research shows that rhodiola root has significant antifatigue, radiation-resisting functional, and it can both improve sportsman
Motion function, can also improve the efficiency of common people's muscle power and mental labour, be referred to as after wilsonii, ginseng environment of new generation
Medicine is adapted to, and is not in the constipating effect of be overexcited effect and the wilsonii of ginseng.
Wilsonii is Araliaceae wilsonii Acanthopanax senticosus（Rupr. et Maxim.）
The drying of Harms, root and rhizome or stem.For replenishing qi to invigorate the spleen, tonify the kidney to relieve mental strain.For the insufficiency of both the spleen and the kindey, body void is weak, and appetite is not
Shake, soreness of waist and knee joint, insomnia and dreamful sleep.There is the pharmacological action such as immunological regulation, antitumor, anti-aging, antifatigue simultaneously.
Beneficial effects of the present invention：
1. the Chinese medicine composition that the present invention is provided is all from natural health care, without any side effects, can be eaten for a long time, and can make
For food, health products and drug development；
2. the present invention combines a large amount of clinics and documents and materials for the Chinese traditional treatment principle of hypoimmunity and physical fatigue,
Under basic theory of tcm is instructed, screened the Chinese medicine material with the gentle physical fatigue of strengthen immunity, with sealwort, the Radix Astragali,
Rhodiola root, wilsonii are primary raw material.Wherein sealwort returns spleen, lung, kidney channel, boosting qi and nourishing yin, invigorating the spleen, moistening lung, kidney-nourishing；The Radix Astragali is returned
Lung, the spleen channel, invigorating middle warmer and replenishing QI；Rhodiola root return lung, the heart channel of Hang-Shaoyin, qi and activate blood circulation, promotes blood circulation and relievings asthma；Wilsonii returns spleen, kidney, the heart channel of Hang-Shaoyin, beneficial gas are good for
Spleen, tonifies the kidney to relieve mental strain.Above-mentioned medicinal material can hit hypoimmunity and physical fatigue patients blood, body fluid loss, visceral dysfunction
Etiology and pathogenesis, promote qi and blood to reconcile, function is coordinated, and reaches the effect for alleviating physical fatigue and strengthen immunity.
3. the health food in the present invention, under instruction of Chinese Medicine theory, by reasonable formula, cooperate with shared, sealwort yin-nourishing,
Radix Astragali tonifying Qi；Rhodiola root qi and activate blood circulation；Wilsonii replenishes qi to invigorate the spleen, number of ways, reach at many levels strengthen immunity, alleviate muscle power
The health care of fatigue；
4. the present invention adopts natural traditional Chinese medicine for raw material, shows through experiment, and the composition that the present invention is provided is exempted from enhancing simultaneously
Epidemic disease power, fatigue-relieving function.
Inventive formulation is that the Radix Astragali, rhodiola root, wilsonii, sealwort this four tastes Chinese medicine material are medicine-food two-purpose.Medicine food two
With food i.e. both can as good to eat food consumption, the food that can be cured the disease as medicinal material again, through for many years even centuries,
Thousands of years eats and is proved, suitable general population long-term consumption useful and harmless to human body, this four tastes raw material green ring in product
Protect, immunity, fatigue-relieving can be strengthened, it is safe, have no adverse reaction.
Specific embodiment
The technical scheme in the embodiment of the present invention is clearly and completely described below, it is clear that described embodiment
Only a part of embodiment of the invention, rather than the embodiment of whole.Based on the embodiment in the present invention, the common skill in this area
The every other embodiment that art personnel are obtained, belongs to the scope of protection of the invention.
Embodiment 1
The Chinese medicine composition of a kind of strengthen immunity, fatigue-relieving, including the raw material of following parts by weight：It is 5 parts of the Radix Astragali, red
10 parts of 5 parts of red-spotted stonecrop, 5 parts of wilsonii and sealwort, or by above-mentioned raw materials water and/or alcohol extract are as active ingredient and pharmaceutically may be used
The pharmaceutical composition of the additives composition of acceptance is preparing raising body immunity, fatigue-relieving food, health food or medicine
In application.
The preparation method of a kind of strengthen immunity, the Chinese medicine composition of fatigue-relieving, comprises the steps：
S1, feeding：Take 10 parts of 5 parts of the Radix Astragali, 5 parts of rhodiola root, 5 parts of wilsonii and sealwort；
The preparation of S2, extract：By above-mentioned raw materials mixing, 80 mesh sieves were crushed, the water for adding 8 times of total dose soaks 40 points
Clock, boils rear small fire and decocts 2 hours, maintains liquid level higher than raw material Chinese medicine height, filters to take filtrate, adds 5 times of total dose
Water, small fire boiling state after boiling maintains liquid level higher than raw material Chinese medicine height, decocts 1 hour, filters and merges filtrate twice, and 60 DEG C of Jing subtracts
Pressure is concentrated into dry cream, crushes, and sieves and obtains final product extract；
S3, preparation of preparation：Said extracted thing is taken, the dextrin of 100 mesh sieves was added, is mixed, with appropriate 50% ethanol（Volume fraction）
Softwood processed, cross 16 mesh nylon mesh, 80 DEG C of dryings, whole grain；Filled with No. 0 Capsules, inspection guarantees capsule grain weight, outward appearance
Conform to quality requirements, content uniformity is controlled in the range of ± 5%, 0.25g/ grains.
Chinese medicine composition human oral recommended amounts of the present invention are 5 every time, and 2 times a day.
Embodiment 2
The Chinese medicine composition of a kind of strengthen immunity, fatigue-relieving, including the raw material of following parts by weight：1 part of the Radix Astragali, rhodiola root
2 parts of 2 parts, 2 parts of wilsonii and sealwort, or by above-mentioned raw materials water and/or alcohol extract as active ingredient and pharmaceutically acceptable
The pharmaceutical composition of additives composition improve in body immunity, fatigue-relieving food, health food or medicine preparing
Using.
The preparation method of a kind of strengthen immunity, the Chinese medicine composition of fatigue-relieving, comprises the steps：
S1, feeding：Take 2 parts of 1 part of the Radix Astragali, 2 parts of rhodiola root, 2 parts of wilsonii and sealwort；
The preparation of S2, extract：By above-mentioned raw materials mixing, 80 mesh sieves were crushed, the water for adding 8 times of total dose soaks 40 points
Clock, boils rear small fire and decocts 2 hours, maintains liquid level higher than raw material Chinese medicine height, filters to take filtrate, adds 5 times of total dose
Water, small fire boiling state after boiling maintains liquid level higher than raw material Chinese medicine height, decocts 1 hour, filters and merges filtrate twice, and 60 DEG C of Jing subtracts
Pressure is concentrated into dry cream, crushes, and sieves and obtains final product extract；
S3, preparation of preparation：Said extracted thing is taken, the dextrin of 100 mesh sieves was added, is mixed, with appropriate 50% ethanol（Volume fraction）
Softwood processed, cross 16 mesh nylon mesh, 80 DEG C of dryings, whole grain；Filled with No. 0 Capsules, inspection guarantees capsule grain weight, outward appearance
Conform to quality requirements, content uniformity is controlled in the range of ± 5%, 0.25g/ grains.
Chinese medicine composition human oral recommended amounts of the present invention are 5 every time, and 2 times a day.
Embodiment 3
The Chinese medicine composition of a kind of strengthen immunity, fatigue-relieving, including the raw material of following parts by weight：6 parts of the Radix Astragali, rhodiola root
10 parts of 8 parts, 5 parts of wilsonii and sealwort, or by above-mentioned raw materials water and/or alcohol extract as active ingredient and pharmaceutically acceptable
The pharmaceutical composition of additives composition improve in body immunity, fatigue-relieving food, health food or medicine preparing
Using.
The preparation method of a kind of strengthen immunity, the Chinese medicine composition of fatigue-relieving, comprises the steps：
S1, feeding：Take 10 parts of 6 parts of the Radix Astragali, 8 parts of rhodiola root, 5 parts of wilsonii and sealwort；
The preparation of S2, extract：By above-mentioned raw materials mixing, 80 mesh sieves were crushed, the water for adding 8 times of total dose soaks 40 points
Clock, boils rear small fire and decocts 2 hours, maintains liquid level higher than raw material Chinese medicine height, filters to take filtrate, adds 5 times of total dose
Water, small fire boiling state after boiling maintains liquid level higher than raw material Chinese medicine height, decocts 1 hour, filters and merges filtrate twice, and 60 DEG C of Jing subtracts
Pressure is concentrated into dry cream, crushes, and sieves and obtains final product extract；
S3, preparation of preparation：Said extracted thing is taken, the dextrin of 100 mesh sieves was added, is mixed, with appropriate 50% ethanol（Volume fraction）
Softwood processed, cross 16 mesh nylon mesh, 80 DEG C of dryings, whole grain；Filled with No. 0 Capsules, inspection guarantees capsule grain weight, outward appearance
Conform to quality requirements, content uniformity is controlled in the range of ± 5%, 0.25g/ grains.
Chinese medicine composition human oral recommended amounts of the present invention are 5 every time, and 2 times a day.
Embodiment 4
The Chinese medicine composition of a kind of strengthen immunity, fatigue-relieving, including the raw material of following parts by weight：3 parts of the Radix Astragali, rhodiola root
6 parts of 4 parts, 3 parts of wilsonii and sealwort, or by above-mentioned raw materials water and/or alcohol extract as active ingredient and pharmaceutically acceptable
The pharmaceutical composition of additives composition improve in body immunity, fatigue-relieving food, health food or medicine preparing
Using.
The preparation method of a kind of strengthen immunity, the Chinese medicine composition of fatigue-relieving, comprises the steps：
S1, feeding：Take 6 parts of 3 parts of the Radix Astragali, 4 parts of rhodiola root, 3 parts of wilsonii and sealwort；
The preparation of S2, extract：By above-mentioned raw materials mixing, 80 mesh sieves were crushed, the water for adding 8 times of total dose soaks 40 points
Clock, boils rear small fire and decocts 2 hours, maintains liquid level higher than raw material Chinese medicine height, filters to take filtrate, adds 5 times of total dose
Water, small fire boiling state after boiling maintains liquid level higher than raw material Chinese medicine height, decocts 1 hour, filters and merges filtrate twice, and 60 DEG C of Jing subtracts
Pressure is concentrated into dry cream, crushes, and sieves and obtains final product extract；
S3, preparation of preparation：Said extracted thing is taken, the dextrin of 100 mesh sieves was added, is mixed, with appropriate 50% ethanol（Volume fraction）
Softwood processed, cross 16 mesh nylon mesh, 80 DEG C of dryings, whole grain；Filled with No. 0 Capsules, inspection guarantees capsule grain weight, outward appearance
Conform to quality requirements, content uniformity is controlled in the range of ± 5%, 0.25g/ grains.
Chinese medicine composition human oral recommended amounts of the present invention are 5 every time, and 2 times a day.
Embodiment 5
The Chinese medicine composition of a kind of strengthen immunity, fatigue-relieving, including the raw material of following parts by weight：5 parts of the Radix Astragali, rhodiola root
10 parts of 8 parts, 5 parts of wilsonii and sealwort, or by above-mentioned raw materials water and/or alcohol extract as active ingredient and pharmaceutically acceptable
The pharmaceutical composition of additives composition improve in body immunity, fatigue-relieving food, health food or medicine preparing
Using.
The preparation method of a kind of strengthen immunity, the Chinese medicine composition of fatigue-relieving, comprises the steps：
S1, feeding：Take 10 parts of 5 parts of the Radix Astragali, 8 parts of rhodiola root, 5 parts of wilsonii and sealwort；
The preparation of S2, extract：By above-mentioned raw materials mixing, 80 mesh sieves were crushed, the water for adding 8 times of total dose soaks 40 points
Clock, boils rear small fire and decocts 2 hours, maintains liquid level higher than raw material Chinese medicine height, filters to take filtrate, adds 5 times of total dose
Water, small fire boiling state after boiling maintains liquid level higher than raw material Chinese medicine height, decocts 1 hour, filters and merges filtrate twice, and 60 DEG C of Jing subtracts
Pressure is concentrated into dry cream, crushes, and sieves and obtains final product extract；
S3, preparation of preparation：Said extracted thing is taken, the dextrin of 100 mesh sieves was added, is mixed, with appropriate 50% ethanol（Volume fraction）
Softwood processed, cross 16 mesh nylon mesh, 80 DEG C of dryings, whole grain；Filled with No. 0 Capsules, inspection guarantees capsule grain weight, outward appearance
Conform to quality requirements, content uniformity is controlled in the range of ± 5%, 0.25g/ grains.
Chinese medicine composition human oral recommended amounts of the present invention are 5 every time, and 2 times a day.
Embodiment 6
The Chinese medicine composition of a kind of strengthen immunity, fatigue-relieving, including the raw material of following parts by weight：It is 5 parts of the Radix Astragali, red
10 parts of 5 parts of red-spotted stonecrop, 5 parts of wilsonii and sealwort, or by above-mentioned raw materials water and/or alcohol extract are as active ingredient and pharmaceutically may be used
The pharmaceutical composition of the additives composition of acceptance is preparing raising body immunity, fatigue-relieving food, health food or medicine
In application.
The preparation method of a kind of strengthen immunity, the Chinese medicine composition of fatigue-relieving, comprises the steps：
The preparation of S1, Rhizoma Polygonati extract：10 parts of sealwort, is dried, crosses 60 mesh sieves, plus 8 times of amount water soak 40 minutes, little after boiling
Fire is decocted 2 hours, maintains liquid level to be higher than medicinal material, filters to take filtrate, and filter residue adds 5 times of amount water, maintains liquid level to be higher than raw material after boiling
Chinese medicine height, decocts 1 hour, filters and merges filtrate twice, and 60 DEG C of Jing is evaporated to dry cream, crushes, and sieving obtains final product sealwort and carry
Take thing；
The preparation of S2, Astragalus Root P.E：5 parts of the Radix Astragali, is dried, crosses 60 mesh sieves, plus 8 times of amount water soak 40 minutes, boil rear small fire
Decoct 2 hours, maintain liquid level to be higher than medicinal material, filter to take filtrate, filter residue adds 5 times of amount water, and liquid level is maintained after boiling higher than in raw material
Medicine height, decocts 1 hour, filters and merges filtrate twice, and 60 DEG C of Jing is evaporated to dry cream, crushes, and sieves and obtains final product sealwort extraction
Thing；
The preparation of S3, gadol extract：5 parts of rhodiola root, is dried, crosses 60 mesh sieves, plus 8 times of amount water soak 40 minutes, after boiling
Small fire is decocted 2 hours, maintains liquid level to be higher than medicinal material, filters to take filtrate, and filter residue adds 5 times of amount water, and liquid level is maintained after boiling higher than original
Material Chinese medicine height, decocts 1 hour, filters and merges filtrate twice, and 60 DEG C of Jing is evaporated to dry cream, crushes, and sieves and obtains final product sealwort
Extract；
The preparation of S4, siberian Ginseng P.E：5 parts of wilsonii, is dried, crosses 60 mesh sieves, plus 8 times of amount water soak 40 minutes, after boiling
Small fire is decocted 2 hours, maintains liquid level to be higher than medicinal material, filters to take filtrate, and filter residue adds 5 times of amount water, and liquid level is maintained after boiling higher than original
Material Chinese medicine height, decocts 1 hour, filters and merges filtrate twice, and 60 DEG C of Jing is evaporated to dry cream, crushes, and sieves and obtains final product sealwort
Extract；
The mixing of S5, extract：The extract for taking above-mentioned sealwort, the Radix Astragali, rhodiola root and wilsonii respectively is mixed；
S6, preparation of preparation：The dextrin of 100 mesh sieves was added, was mixed, with 50% ethanol softwood, 16 mesh nylon mesh of mistake, 80 DEG C
It is dried, whole grain, 50 bags of granule, 4g/ bags are made in pack.
Granule human oral recommended amounts of the present invention are 1 bag every time, and 2 times a day.
Embodiment 7
The Chinese medicine composition of a kind of strengthen immunity, fatigue-relieving, including the raw material of following parts by weight：1 part of the Radix Astragali, rhodiola root
2 parts of 2 parts, 2 parts of wilsonii and sealwort, or by above-mentioned raw materials water and/or alcohol extract as active ingredient and pharmaceutically acceptable
The pharmaceutical composition of additives composition improve in body immunity, fatigue-relieving food, health food or medicine preparing
Using.
The preparation method of a kind of strengthen immunity, the Chinese medicine composition of fatigue-relieving, comprises the steps：
The preparation of S1, Rhizoma Polygonati extract：2 parts of sealwort, is dried, crosses 60 mesh sieves, plus 8 times of amount water soak 40 minutes, boil rear small fire
Decoct 2 hours, maintain liquid level to be higher than medicinal material, filter to take filtrate, filter residue adds 5 times of amount water, and liquid level is maintained after boiling higher than in raw material
Medicine height, decocts 1 hour, filters and merges filtrate twice, and 60 DEG C of Jing is evaporated to dry cream, crushes, and sieves and obtains final product sealwort extraction
Thing；
The preparation of S2, Astragalus Root P.E：1 part of the Radix Astragali, is dried, crosses 60 mesh sieves, plus 8 times of amount water soak 40 minutes, boil rear small fire
Decoct 2 hours, maintain liquid level to be higher than medicinal material, filter to take filtrate, filter residue adds 5 times of amount water, and liquid level is maintained after boiling higher than in raw material
Medicine height, decocts 1 hour, filters and merges filtrate twice, and 60 DEG C of Jing is evaporated to dry cream, crushes, and sieves and obtains final product sealwort extraction
Thing；
The preparation of S3, gadol extract：2 parts of rhodiola root, is dried, crosses 60 mesh sieves, plus 8 times of amount water soak 40 minutes, after boiling
Small fire is decocted 2 hours, maintains liquid level to be higher than medicinal material, filters to take filtrate, and filter residue adds 5 times of amount water, and liquid level is maintained after boiling higher than original
Material Chinese medicine height, decocts 1 hour, filters and merges filtrate twice, and 60 DEG C of Jing is evaporated to dry cream, crushes, and sieves and obtains final product sealwort
Extract；
The preparation of S4, siberian Ginseng P.E：2 parts of wilsonii, is dried, crosses 60 mesh sieves, plus 8 times of amount water soak 40 minutes, after boiling
Small fire is decocted 2 hours, maintains liquid level to be higher than medicinal material, filters to take filtrate, and filter residue adds 5 times of amount water, and liquid level is maintained after boiling higher than original
Material Chinese medicine height, decocts 1 hour, filters and merges filtrate twice, and 60 DEG C of Jing is evaporated to dry cream, crushes, and sieves and obtains final product sealwort
Extract；
The mixing of S5, extract：The extract for taking above-mentioned sealwort, the Radix Astragali, rhodiola root and wilsonii respectively is mixed；
S6, preparation of preparation：The dextrin of 100 mesh sieves was added, was mixed, with 50% ethanol softwood, 16 mesh nylon mesh of mistake, 80 DEG C
It is dried, whole grain, 50 bags of granule, 4g/ bags are made in pack.
Granule human oral recommended amounts of the present invention are 1 bag, daily 2 times every time.
Embodiment 8
The Chinese medicine composition of a kind of strengthen immunity, fatigue-relieving, including the raw material of following parts by weight：6 parts of the Radix Astragali, rhodiola root
10 parts of 8 parts, 5 parts of wilsonii and sealwort, or by above-mentioned raw materials water and/or alcohol extract as active ingredient and pharmaceutically acceptable
The pharmaceutical composition of additives composition improve in body immunity, fatigue-relieving food, health food or medicine preparing
Using.
The preparation method of a kind of strengthen immunity, the Chinese medicine composition of fatigue-relieving, comprises the steps：
The preparation of S1, Rhizoma Polygonati extract：10 parts of sealwort, is dried, crosses 60 mesh sieves, plus 8 times of amount water soak 40 minutes, little after boiling
Fire is decocted 2 hours, maintains liquid level to be higher than medicinal material, filters to take filtrate, and filter residue adds 5 times of amount water, maintains liquid level to be higher than raw material after boiling
Chinese medicine height, decocts 1 hour, filters and merges filtrate twice, and 60 DEG C of Jing is evaporated to dry cream, crushes, and sieving obtains final product sealwort and carry
Take thing；
The preparation of S2, Astragalus Root P.E：6 parts of the Radix Astragali, is dried, crosses 60 mesh sieves, plus 8 times of amount water soak 40 minutes, boil rear small fire
Decoct 2 hours, maintain liquid level to be higher than medicinal material, filter to take filtrate, filter residue adds 5 times of amount water, and liquid level is maintained after boiling higher than in raw material
Medicine height, decocts 1 hour, filters and merges filtrate twice, and 60 DEG C of Jing is evaporated to dry cream, crushes, and sieves and obtains final product sealwort extraction
Thing；
The preparation of S3, gadol extract：8 parts of rhodiola root, is dried, crosses 60 mesh sieves, plus 8 times of amount water soak 40 minutes, after boiling
Small fire is decocted 2 hours, maintains liquid level to be higher than medicinal material, filters to take filtrate, and filter residue adds 5 times of amount water, and liquid level is maintained after boiling higher than original
Material Chinese medicine height, decocts 1 hour, filters and merges filtrate twice, and 60 DEG C of Jing is evaporated to dry cream, crushes, and sieves and obtains final product sealwort
Extract；
The preparation of S4, siberian Ginseng P.E：5 parts of wilsonii, is dried, crosses 60 mesh sieves, plus 8 times of amount water soak 40 minutes, after boiling
Small fire is decocted 2 hours, maintains liquid level to be higher than medicinal material, filters to take filtrate, and filter residue adds 5 times of amount water, and liquid level is maintained after boiling higher than original
Material Chinese medicine height, decocts 1 hour, filters and merges filtrate twice, and 60 DEG C of Jing is evaporated to dry cream, crushes, and sieves and obtains final product sealwort
Extract；
The mixing of S5, extract：The extract for taking above-mentioned sealwort, the Radix Astragali, rhodiola root and wilsonii respectively is mixed；
S6, preparation of preparation：The dextrin of 100 mesh sieves was added, was mixed, with 50% ethanol softwood, 16 mesh nylon mesh of mistake, 80 DEG C
It is dried, whole grain, 50 bags of granule, 4g/ bags are made in pack.
Granule human oral recommended amounts of the present invention are 1 bag, daily 2 times every time.
Embodiment 9
The Chinese medicine composition of a kind of strengthen immunity, fatigue-relieving, including the raw material of following parts by weight：3 parts of the Radix Astragali, rhodiola root
6 parts of 4 parts, 3 parts of wilsonii and sealwort, or by above-mentioned raw materials water and/or alcohol extract as active ingredient and pharmaceutically acceptable
The pharmaceutical composition of additives composition improve in body immunity, fatigue-relieving food, health food or medicine preparing
Using.
The preparation method of a kind of strengthen immunity, the Chinese medicine composition of fatigue-relieving, comprises the steps：
The preparation of S1, Rhizoma Polygonati extract：6 parts of sealwort, is dried, crosses 60 mesh sieves, plus 8 times of amount water soak 40 minutes, boil rear small fire
Decoct 2 hours, maintain liquid level to be higher than medicinal material, filter to take filtrate, filter residue adds 5 times of amount water, and liquid level is maintained after boiling higher than in raw material
Medicine height, decocts 1 hour, filters and merges filtrate twice, and 60 DEG C of Jing is evaporated to dry cream, crushes, and sieves and obtains final product sealwort extraction
Thing；
The preparation of S2, Astragalus Root P.E：3 parts of the Radix Astragali, is dried, crosses 60 mesh sieves, plus 8 times of amount water soak 40 minutes, boil rear small fire
Decoct 2 hours, maintain liquid level to be higher than medicinal material, filter to take filtrate, filter residue adds 5 times of amount water, and liquid level is maintained after boiling higher than in raw material
Medicine height, decocts 1 hour, filters and merges filtrate twice, and 60 DEG C of Jing is evaporated to dry cream, crushes, and sieves and obtains final product sealwort extraction
Thing；
The preparation of S3, gadol extract：4 parts of rhodiola root, is dried, crosses 60 mesh sieves, plus 8 times of amount water soak 40 minutes, after boiling
Small fire is decocted 2 hours, maintains liquid level to be higher than medicinal material, filters to take filtrate, and filter residue adds 5 times of amount water, and liquid level is maintained after boiling higher than original
Material Chinese medicine height, decocts 1 hour, filters and merges filtrate twice, and 60 DEG C of Jing is evaporated to dry cream, crushes, and sieves and obtains final product sealwort
Extract；
The preparation of S4, siberian Ginseng P.E：3 parts of wilsonii, is dried, crosses 60 mesh sieves, plus 8 times of amount water soak 40 minutes, after boiling
Small fire is decocted 2 hours, maintains liquid level to be higher than medicinal material, filters to take filtrate, and filter residue adds 5 times of amount water, and liquid level is maintained after boiling higher than original
Material Chinese medicine height, decocts 1 hour, filters and merges filtrate twice, and 60 DEG C of Jing is evaporated to dry cream, crushes, and sieves and obtains final product sealwort
Extract；
The mixing of S5, extract：The extract for taking above-mentioned sealwort, the Radix Astragali, rhodiola root and wilsonii respectively is mixed；
S6, preparation of preparation：The dextrin of 100 mesh sieves was added, was mixed, with 50% ethanol softwood, 16 mesh nylon mesh of mistake, 80 DEG C
It is dried, whole grain, 50 bags of granule, 4g/ bags are made in pack.
Granule human oral recommended amounts of the present invention are 1 bag, daily 2 times every time.
Embodiment 10
The Chinese medicine composition of a kind of strengthen immunity, fatigue-relieving, including the raw material of following parts by weight：5 parts of the Radix Astragali, rhodiola root
10 parts of 8 parts, 5 parts of wilsonii and sealwort, or by above-mentioned raw materials water and/or alcohol extract as active ingredient and pharmaceutically acceptable
The pharmaceutical composition of additives composition improve in body immunity, fatigue-relieving food, health food or medicine preparing
Using.
The preparation method of a kind of strengthen immunity, the Chinese medicine composition of fatigue-relieving, comprises the steps：
The preparation of S1, Rhizoma Polygonati extract：10 parts of sealwort, is dried, crosses 60 mesh sieves, plus 8 times of amount water soak 40 minutes, little after boiling
Fire is decocted 2 hours, maintains liquid level to be higher than medicinal material, filters to take filtrate, and filter residue adds 5 times of amount water, maintains liquid level to be higher than raw material after boiling
Chinese medicine height, decocts 1 hour, filters and merges filtrate twice, and 60 DEG C of Jing is evaporated to dry cream, crushes, and sieving obtains final product sealwort and carry
Take thing；
The preparation of S2, Astragalus Root P.E：5 parts of the Radix Astragali, is dried, crosses 60 mesh sieves, plus 8 times of amount water soak 40 minutes, boil rear small fire
Decoct 2 hours, maintain liquid level to be higher than medicinal material, filter to take filtrate, filter residue adds 5 times of amount water, and liquid level is maintained after boiling higher than in raw material
Medicine height, decocts 1 hour, filters and merges filtrate twice, and 60 DEG C of Jing is evaporated to dry cream, crushes, and sieves and obtains final product sealwort extraction
Thing；
The preparation of S3, gadol extract：8 parts of rhodiola root, is dried, crosses 60 mesh sieves, plus 8 times of amount water soak 40 minutes, after boiling
Small fire is decocted 2 hours, maintains liquid level to be higher than medicinal material, filters to take filtrate, and filter residue adds 5 times of amount water, and liquid level is maintained after boiling higher than original
Material Chinese medicine height, decocts 1 hour, filters and merges filtrate twice, and 60 DEG C of Jing is evaporated to dry cream, crushes, and sieves and obtains final product sealwort
Extract；
The preparation of S4, siberian Ginseng P.E：5 parts of wilsonii, is dried, crosses 60 mesh sieves, plus 8 times of amount water soak 40 minutes, after boiling
Small fire is decocted 2 hours, maintains liquid level to be higher than medicinal material, filters to take filtrate, and filter residue adds 5 times of amount water, and liquid level is maintained after boiling higher than original
Material Chinese medicine height, decocts 1 hour, filters and merges filtrate twice, and 60 DEG C of Jing is evaporated to dry cream, crushes, and sieves and obtains final product sealwort
Extract；
The mixing of S5, extract：The extract for taking above-mentioned sealwort, the Radix Astragali, rhodiola root and wilsonii respectively is mixed；
S6, preparation of preparation：The dextrin of 100 mesh sieves was added, was mixed, with 50% ethanol softwood, 16 mesh nylon mesh of mistake, 80 DEG C
It is dried, whole grain, 50 bags of granule, 4g/ bags are made in pack.
Granule human oral recommended amounts of the present invention are 1 bag, daily 2 times every time.
Embodiment 11
Chinese medicine composition obtained in above-described embodiment 1 to 10 is taken, adds customary adjuvant, mixed, conventionally, be pressed into
Piece, film coating is obtained Chinese medicinal tablet.
Embodiment 12
Chinese medicine composition obtained in above-described embodiment 1 to 10 is taken, adds customary adjuvant, mixed, conventionally, granulation is filled out
Capsule is filled, Chinese medicine capsules are obtained.
Embodiment 13
Chinese medicine composition obtained in above-described embodiment 1 to 10 is taken, adds customary adjuvant, mixed, according to conventional modeling preparation method or general system
Method, is obtained medicine pill.
Embodiment 14
Chinese medicine composition obtained in above-described embodiment 1 to 10 is taken, adds customary adjuvant, mixed, conventionally, whole grain is done
It is dry, Chinese herbal granules are obtained.
Embodiment 15
Chinese medicine composition obtained in above-described embodiment 1 to 10 is taken, adds customary adjuvant, conventionally prepare Tea containing traditional Chinese medicine
Agent.
Embodiment 16
Chinese medicine composition obtained in above-described embodiment 1 to 10 is taken, adds customary adjuvant, conventionally prepare traditional Chinese medicine mouth
Take liquid.
Embodiment 17
Chinese medicine composition obtained in above-described embodiment 1 to 10 is taken, adds customary adjuvant, conventionally prepare powder of Chinese traditional medicine
Agent.
Embodiment 18
A kind of application of strengthen immunity, the Chinese medicine composition of fatigue-relieving, the Chinese medicine composition prepare strengthen immunity,
Alleviate the application in food, health products or the medicine of organism fatigue.
The Chinese medicine composition Toxicity Analysis experiment of the present invention of embodiment 19
The impact of 19.1 pairs of immune function of mice
Normal mouse 50 is taken, first adapts to raise 3 d, be then randomly divided into 5 groups:Control group, model group, the low dosage of embodiment 1
Group (650mg/kg), the middle dose group of embodiment 1 (1300mg/kg) and the high dose group of embodiment 1 (2600mg/kg), embodiment 2
Low dose group (400m g/kg), the middle dose group of embodiment 2 (800mg/kg) and the high dose group of embodiment 2 (1600mg/kg) are per group
10.The daily gastric infusion of administration group 1 time, control group and model group are continuously given with isopyknic physiological saline gavage, sample
The d of mouse 30, blank control group and model group give daily isopyknic physiological saline, in addition to blank control group, after the 3rd week
Start to give endoxan or hydrocortisone immunodepressant：Endoxan presses 40 mgkg-1Dosage, lumbar injection, even
It is continuous two days, determine indices within the 5th day after final injection administration.
Spleen and thymus index are determined：Next day after mouse last dose, put to death, weigh.Spleen and thymus gland are taken, spleen is weighed respectively
Dirty and thymic weight, draws spleen/body weight value and thymus gland/body weight value.
Carbon grain Kuo clear law is determined after the min of non-specific immune function last dose 30, tail vein injection india ink
0.005-0.01ml/g (prepared Chinese ink first uses 10 times of normal saline dilution), respectively at 1 after injection, 5 min eye sockets take the μ L of blood 20, molten
In the Na of 2mL 0.1%2CO3In shake up, under ultraviolet specrophotometer at 600 nm survey its absorbance A, calculate phagocyte imdex K
With phagocytic index α.
As shown in table 1, the impact situation of various dose embodiment 1 and the sample of embodiment 2 to mouse immune shoot formation is shown in
Table 1.Compared with blank group, with the increase of embodiment 1 and the sample size of embodiment 2, the Thymus and Spleen index of mouse by
Gradually improve.Compared with model group, the Thymus and Spleen index of embodiment 1 and the sample sets mouse of embodiment 2 has and significantly carries
It is high.
Impact of the table 1 to mouse immune shoot formation（х ± s, n=10）
Note：Compared with model group,*P<0.05,**P<0.01
The impact of 19.2 pairs of mouse anti-reflecting fatigue effects
Normal mouse 80 is taken, first adapts to raise 3 d, be then randomly divided into 8 groups：Blank group, positive controls（Commercially available wilsonii
Capsule 800mg/kg）, the low dose group of embodiment 1 (650mg/kg), the middle dose group of embodiment 1 (1300mg/kg) and embodiment 1
High dose group (2600mg/kg), the low dose group of embodiment 2 (400m g/kg), the middle dose group of embodiment 2 (800mg/kg) and reality
Apply the high dose group of example 2 (1600mg/kg) 10 per group.The daily gastric infusion of administration group 1 time, control group and model group equal-volume
Physiological saline gavage, sample continuously gives the d of mouse 30, and blank control group and model group give daily isopyknic physiology salt
Water, after the min of last dose 30, in the heavy burden 5% at the cm of root of the tail 1, in being put into swimming trunk, with mouse underwater 10 is sunk to
S can not float and be judged to power and exhaust, and record from entering the time that water to power exhausts.
Mice serum urea, creatine kinase determine packet with administration ibid.After the min of mouse last gavage 30, cervical dislocation
Put to death, take hindlimb muscle and liver about 50mg immediately at same position, with normal saline flushing after, blotted, weighed with filter paper, press
Kit specification determines Body development and liver glycogen content.
Table 2：Impact to the mice burden swimming time（х ± s, n=10）
Note：Compared with blank group,*P<0.05,**P<0.01
Table 3：Impact to mouse Body development and liver glycogen content
Note：Compared with blank group,*P<0.05,**P<0.01
The result of table 2 shows that in swimming with a load attached to the body experiment, each group mouse is given after medicine, positive control drug, embodiment 1, embodiment
2 high middle dose group mouse swimming time poles are considerably longer than blank group (P ＜ 0.01)；Embodiment 1, the low dose group of embodiment 2 are notable
Higher than blank group (P ＜ 0.05).
After each group administration, positive control drug, the high middle dose group Mouse Muscle glycogen of embodiment 1, embodiment 2 and liver glycogen content
Pole is significantly higher than blank group (P ＜ 0.01)；Embodiment 1, the low dose group mouse Body development of embodiment 2 and liver glycogen content are notable
Higher than blank group (P ＜ 0.05).
Visible according to above-mentioned experimental result, what the present invention was prepared possesses in enhance immunity, fatigue-relieving function
Drug composition, pharmacological evaluation shows that its raw material components has collaboration enhance immunity, fatigue-relieving function.
Presently preferred embodiments of the present invention is the foregoing is only, not to limit the present invention, all essences in the present invention
Within god and principle, any modification, equivalent substitution and improvements made etc. should be included within the scope of the present invention.
Claims (10)
1. the Chinese medicine composition of a kind of strengthen immunity, fatigue-relieving, it is characterised in that：Including the raw material of following parts by weight：
2～10 parts of 1～6 part of the Radix Astragali, 2～8 parts of rhodiola root, 2～5 parts of wilsonii and sealwort, or by the water and/or alcohol extract of above-mentioned raw materials
It is tired in preparation raising body immunity, alleviation as the pharmaceutical composition of active ingredient and pharmaceutically acceptable additives composition
Application in labor food, health food or medicine.
2. the Chinese medicine composition of strengthen immunity according to claim 1, fatigue-relieving, it is characterised in that：Including as follows
6～10 parts of 3～5 parts of the Radix Astragali, 4～8 parts of rhodiola root, 3～5 parts of wilsonii and sealwort, or by the water and/or alcohol of above-mentioned raw materials
Extract is preparing raising body immunity, is delaying as the pharmaceutical composition of active ingredient and pharmaceutically acceptable additives composition
Application in solution fatigue food, health food or medicine.
3. the Chinese medicine composition of strengthen immunity according to claim 2, fatigue-relieving, it is characterised in that：The Radix Astragali 5
Part, 5 parts of rhodiola root, 5 parts of wilsonii and 10 parts of sealwort, or by above-mentioned raw materials water and/or alcohol extract as active ingredient and medicine
The pharmaceutical composition of acceptable additives composition is preparing raising body immunity, fatigue-relieving food, health food on
Or the application in medicine.
4. a kind of strengthen immunity, the preparation method of the Chinese medicine composition of fatigue-relieving, it is characterised in that：Comprise the steps：
S1, feeding：Take 2～10 parts of 1～6 part of the Radix Astragali, 2～8 parts of rhodiola root, 2～5 parts of wilsonii and sealwort；
The preparation of S2, extract：By above-mentioned raw materials mixing, pulverize and sieve, add water to cook 1-3 acquisition filtrate, 60 DEG C of decompressions of Jing
Dry cream is concentrated into, is crushed, sieved and obtain final product extract；
S3, preparation of preparation：Said extracted thing is taken, the dextrin of 100 mesh sieves was added, is mixed, with the softwood processed of 50% ethanol, cross 16
Mesh nylon mesh, 80 DEG C of dryings, whole grain.
5. strengthen immunity according to claim 4, the preparation method of the Chinese medicine composition of fatigue-relieving, its feature exists
In：It is the water for adding bulk drug gross weight 5-8 times in step S2.
6. a kind of strengthen immunity, the preparation method of the Chinese medicine composition of fatigue-relieving, it is characterised in that：Comprise the steps：
The preparation of S1, Rhizoma Polygonati extract：Sealwort 2-10 parts, are dried, sieve, and add water to cook 1-3 acquisition filtrate, 60 DEG C of decompressions of Jing
Dry cream is concentrated into, is crushed, sieved and obtain final product Rhizoma Polygonati extract；
The preparation of S2, Astragalus Root P.E：Radix Astragali 1-6 parts, are dried, sieve, and add water to cook 1-3 acquisition filtrate, 60 DEG C of decompressions of Jing
Dry cream is concentrated into, is crushed, sieved and obtain final product Rhizoma Polygonati extract；
The preparation of S3, gadol extract：Rhodiola root 2-8 parts, are dried, sieve, and add water to cook 1-3 acquisition filtrate, 60 DEG C of Jing
Dry cream is evaporated to, is crushed, sieved and obtain final product Rhizoma Polygonati extract；
The preparation of S4, siberian Ginseng P.E：Wilsonii 2-5 parts, are dried, sieve, and add water to cook 1-3 acquisition filtrate, 60 DEG C of Jing
Dry cream is evaporated to, is crushed, sieved and obtain final product Rhizoma Polygonati extract；
The mixing of S5, extract：The extract for taking above-mentioned sealwort, the Radix Astragali, rhodiola root and wilsonii respectively is mixed；
S6, preparation of preparation：The dextrin of 100 mesh sieves was added, was mixed, with 50% ethanol softwood, 16 mesh nylon mesh of mistake, 80 DEG C
It is dried, whole grain.
7. strengthen immunity according to claim 6, the preparation method of the Chinese medicine composition of fatigue-relieving, its feature exists
In：It is the water for adding bulk drug weight 5-8 times in step S1-S4.
8. the Chinese medicine preparation of a kind of strengthen immunity, fatigue-relieving, it is characterised in that：Including Chinese medicine as claimed in claim 1
Composition and pharmaceutically acceptable auxiliary material.
9. the Chinese medicine preparation of strengthen immunity according to claim 8, fatigue-relieving, it is characterised in that：It is oral system
Agent, the oral formulations include pressed candy, tea in bag, instant tea, tablet, capsule, powder, pill, granule, oral liquid
Or injection.
10. a kind of strengthen immunity, the application of the Chinese medicine composition of fatigue-relieving, it is characterised in that：Including such as claim 1-9
Chinese medicine composition described in any one claim is in food, health products or the medicine for preparing strengthen immunity, alleviate organism fatigue
In application.
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Cited By (6)
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| CN107467666A (en) * | 2017-09-19 | 2017-12-15 | 房洪全 | It is a kind of to improve health food of immunity and preparation method thereof |
| CN108936654A (en) * | 2018-06-12 | 2018-12-07 | 北京筑元吉康医药科技有限责任公司 | A kind of health food of strengthen immunity and its application |
| CN109363175A (en) * | 2018-11-01 | 2019-02-22 | 云南香绿源科技开发有限公司 | A kind of functionality integration of drinking and medicinal herbs food and preparation method thereof |
| CN109363173A (en) * | 2018-10-26 | 2019-02-22 | 内蒙古中健宝生物科技有限公司 | A kind of Milkvetch root composition and Radix Astragali water prepared therefrom and preparation method thereof |
| CN112386637A (en) * | 2019-08-19 | 2021-02-23 | 香港中文大学 | Anti-fatigue pharmaceutical composition and preparation method thereof |
| CN115252723A (en) * | 2022-06-24 | 2022-11-01 | 河北医科大学第一医院 | A Chinese medicinal composition for relieving fatigue and improving sleep, and its preparation method |
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| CN101081281A (en) * | 2006-05-30 | 2007-12-05 | 北京身心康生物科技有限公司 | Anti-fatigue resistibility capsules for improving body immunity and method for making same |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN107467666A (en) * | 2017-09-19 | 2017-12-15 | 房洪全 | It is a kind of to improve health food of immunity and preparation method thereof |
| CN108936654A (en) * | 2018-06-12 | 2018-12-07 | 北京筑元吉康医药科技有限责任公司 | A kind of health food of strengthen immunity and its application |
| CN109363173A (en) * | 2018-10-26 | 2019-02-22 | 内蒙古中健宝生物科技有限公司 | A kind of Milkvetch root composition and Radix Astragali water prepared therefrom and preparation method thereof |
| CN109363175A (en) * | 2018-11-01 | 2019-02-22 | 云南香绿源科技开发有限公司 | A kind of functionality integration of drinking and medicinal herbs food and preparation method thereof |
| CN112386637A (en) * | 2019-08-19 | 2021-02-23 | 香港中文大学 | Anti-fatigue pharmaceutical composition and preparation method thereof |
| CN112386637B (en) * | 2019-08-19 | 2022-06-21 | 香港中文大学 | Anti-fatigue pharmaceutical composition and preparation method thereof |
| CN115252723A (en) * | 2022-06-24 | 2022-11-01 | 河北医科大学第一医院 | A Chinese medicinal composition for relieving fatigue and improving sleep, and its preparation method |
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