CN106511777A - Dendrobium huoshanense-containing traditional Chinese medicinal composition having anti-fatigue effect, and preparation method thereof - Google Patents
Dendrobium huoshanense-containing traditional Chinese medicinal composition having anti-fatigue effect, and preparation method thereof Download PDFInfo
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/254—Acanthopanax or Eleutherococcus
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
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- A61K36/88—Liliopsida (monocotyledons)
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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Abstract
The invention relates to a Dendrobium huoshanense-containing traditional Chinese medicinal composition having an anti-fatigue effect, and a preparation method thereof. The composition can be used for making traditional Chinese medicinal preparations. The Dendrobium huoshanense-containing traditional Chinese medicinal composition having an anti-fatigue effect is prepared through combing the following raw materials: Dendrobium huoshanense, ginseng and Manyprickle Acathopanax Root according to a determined weight part ratio. The preparation method of the Dendrobium huoshanense-containing traditional Chinese medicinal composition having an anti-fatigue effect comprises the following steps: 1, selecting above traditional Chinese medicinal materials according to the determined weight part ratio, wherein the traditional Chinese medicinal materials are Dendrobium huoshanense, ginseng and Manyprickle Acathopanax Root; and 2, and processing the selected traditional Chinese medicinal materials: mixing the selected traditional Chinese medicinal materials, adding a solvent ethanol to prepare a mixed solution, carrying out refluxing extraction to extract medicine components dissolved in the mixed solution in order to obtain an extract liquid with medicinal values in the mixed liquid, filtering out medicine residues, and processing the obtained extract liquid to obtain the traditional Chinese medicinal composition.
Description
Technical field
It is the invention belongs to medicine and health product technology field, and in particular to a kind of Chinese medicine composition and preparation method thereof, special
It is not Chinese medicine composition with antifatigue effect containing Dendrobidium huoshanness and preparation method thereof.The present invention is tired with resisting for preparing
The product of work, including medicine and health products.
Background technology
With the aggravation accelerated with social competition of modern life rhythm, many people are because work, study and dinner party etc. are square
The pressure in face, causes body of excessively overdrawing so that physical condition is impacted again, as far as the applicant is aware, physical fatigue is
Become the practical problem of many people's health of puzzlement.
According to relevant information introduction, fatigue refers to that organism physiology process can not continue its function on specified level or can not tie up
The physiological reaction in specific exercise intensity is held, this physiological reaction is appeared on multiple organs of body, and in many devices
Official, many tissues, it is multi-level in complicated change can occur, and may also can belong to sub-health state model with psychology change, fatigue
Farmland.In traditional Chinese medicine books, there is " consumptive disease ", " slacking off ", " slack lazy ", " four limbs overstrain " and " inability to raise limbs " etc. to describe to fatigue.
Have various to the cure of fatigue, mainly medicine auxiliary treatment, food auxiliary treatment and reinforcement physical exercise.
At present, the anti-fatigue product on market can substantially be divided into following a few classes：
1st, supplement energy, body normal physiological function, fatigue-relieving are maintained by supplementing the trophic factors of body consumption and reaching
Purpose.
2nd, supplement vitamin needed by human and trace element.
3rd, by improving and improving the function of body, the poised state of body is rebuild, acceleration bodies intracellular metabolite material
Remove and discharge, reach antifatigue purpose.
Many Chinese medicine preparations belong to the 3rd class product.
Existing anti-fatigue health-product containing on market, kind are more, and action effect is different, and quality is also uneven.According to
Known to applicant, some anti-fatigue health-caring products there is a problem of certain, and its curative effect awaits further verifying.
The content of the invention
The purpose of the present invention is, for prior art Shortcomings, to be improved, and proposes and study have containing Dendrobidium huoshanness
Compound preparation of antifatigue effect and preparation method thereof.
The present invention technical solution be：The Chinese medicine composition for having antifatigue effect containing Dendrobidium huoshanness tool, using in
Medicinal material, is combined by ratio of weight and the number of copies, it is characterised in that the Chinese medicine of employing includes Dendrobidium huoshanness, ginseng, wilsonii；By weight
The Dendrobidium huoshanness of portion rate combination, ginseng, wilsonii constitute Chinese medicine composition.
Characterized in that, the respective parts by weight of the Dendrobidium huoshanness for combining by ratio of weight and the number of copies, ginseng, wilsonii are：Suddenly
1～5 part of the mountain stem of noble dendrobium, 2～6 parts of ginseng, 1～3 part of wilsonii.
Characterized in that, the respective parts by weight of the Dendrobidium huoshanness for combining by ratio of weight and the number of copies, ginseng, wilsonii are：Suddenly
3 parts of the mountain stem of noble dendrobium, 4 parts of ginseng, 2 parts of wilsonii.
The preparation method of the Chinese medicine composition for having antifatigue effect containing Dendrobidium huoshanness tool, by the ratio of weight and number choosing for determining
Chinese medicine is selected, the Chinese medicine to selecting is processed, and obtains Chinese medicine composition, it is characterised in that in selecting by ratio of weight and the number of copies
Medicinal material is Dendrobidium huoshanness, ginseng, wilsonii；The method being processed to the Chinese medicine for selecting is to mix the Chinese medicine for choosing
It is combined, adds etoh solvent to make mixed liquor, using the method for refluxing extraction, the pharmaceutical compositions of dissolution in mixed liquor are entered
Row is extracted, the extract for having medical value in obtaining mixed liquor, filters off the dregs of a decoction, extract is processed, Chinese traditional medicine composition is obtained
Thing；The Chinese medicine composition for obtaining be containing Dendrobidium huoshanness, ginseng, wilsonii pharmaceutical compositions Chinese medicine composition；Step includes：
Step 1, selects Chinese medicine：Dendrobidium huoshanness, ginseng, wilsonii are weighed in proportion；
Step 2, produces mixed liquor：To weigh in proportion Dendrobidium huoshanness, ginseng, wilsonii mixing after, add etoh solvent make
Mixed liquor, fully stirs companion to the medicine in mixed liquor, improves the liquor strength of drug-eluting in mixed liquor；
Step 3, refluxing extraction：Using the method for refluxing extraction, the mixed liquor produced to step 2 carries out refluxing extraction, will mixing
Liquid refluxing extraction 2 times, 2～3 hours every time, filters off the dregs of a decoction；
Step 4, is processed to extract：The extract of 2 extractions in combining step 3, the extract to merging reduce pressure
Concentration, and it is spray-dried, dried powder is obtained, dried powder is sieved, obtained containing Dendrobidium huoshanness, ginseng and wilsonii medicine
The Chinese medicine composition of thing composition.
Characterized in that, the concentration of the etoh solvent added in step 2 is 60%.
A kind of Chinese medicine preparation by made by the Chinese medicine composition with antifatigue effect containing Dendrobidium huoshanness, including it is pharmaceutical
Auxiliary material, it is characterised in that adopt the Chinese medicine composition with antifatigue effect containing Dendrobidium huoshanness, according to preparation needs,
A certain amount of pharmaceutical auxiliary material is equipped with the ratio for determining in the Chinese medicine composition of the antifatigue effect containing Dendrobidium huoshanness, is made
Chinese medicine preparation with antifatigue effect.
Characterized in that, made by have antifatigue effect Chinese medicine preparation be sustained release agent in medical common formulations,
Granula, capsule, dripping pill, tablet, oral liquid.
Characterized in that, made by have antifatigue effect Chinese medicine preparation be sustained release agent in medical common formulations,
It is a kind of in granula, capsule, capsule, tablet, oral liquid.
The Chinese medicine that the present invention is adopted（Dendrobidium huoshanness, ginseng, wilsonii）The Ji Yuan of each component and medicinal, health care are such as
Under：
Dendrobidium huoshanness：The stem of noble dendrobium be orchid family Dendrobium (Dendrobium) herbaceos perennial, it is China's tradition rare Chinese medicine,
《Sheng Nong's herbal classic》、《Taoist Scriptures》、《Compendium of Materia Medica》、《Preemergency a thousand pieces of gold prescription》It is on the books etc. in many classic medical books.According to going through
Generation book on Chinese herbal medicine is recorded and is understood, the stem of noble dendrobium has nourishing Yin and clearing heat, the beneficial stomach that promotes the production of body fluid, the improving eyesight that wets one's whistle, ground of promoting longevity, tonifying five zang organs consumptive disease sea thin,
The effect of Qiang Yinhe is except abnormal heat etc..Wherein,《Road a surname》In one book, the stem of noble dendrobium and Herba Saussureae Involueratae, three liang of ginsengs, 120 years it is first
Crow, the Poria cocos of cycle of sixty years, desert cistanche, remote mountains glossy ganoderma, seabed pearl, Cordyceps sinensis etc. are classified as Chinese " nine big celestial grass ", and in being listed in
First of Hua Jiu great celestial grass.
Modern medicine study shows that the active component of the stem of noble dendrobium mainly has the chemical compositions such as alkaloid, amino acid and polysaccharide.
Relevant pharmacological research confirms, the stem of noble dendrobium improve human immunological competence, anti-aging, it is antitumor, improve diabetic symptom, treatment atrophy
Property the aspect such as gastritis have significant curative effect, side effect after being particularly used in recent years eliminating cancer radiation, chemotherapy and recover function side
Face, effect are fairly obvious.
As far as the applicant is aware, in all stem of noble dendrobium products, being included in the Dendrobidium huoshanness of Huoshan product（Also known as rice dry measure used in former times）, iron sheet
The stem of noble dendrobium and Dendrobium Moniliforme, Dendrobidium huoshanness are optimal.《Sheng Nong's herbal classic》Record, " stem of noble dendrobium life six is pacified by the water of mountain valley on stone, August in July
Adopt stem to dry in the shade ", this is the earliest record in history tree to the stem of noble dendrobium place of production and habitat.In main three kinds of stem of noble dendrobium kinds that is produced from Huoshan
In, Dendrobidium huoshanness（Dendrobium huoshanense, rice dry measure used in former times）The most rare precious, it is into remedies just to be praised highly by doctor from ancient times
Treasure in dry measure used in former times, is referred to as " help celestial grass ", " soft gold ", " plant gold ",《Compendium of Materia Medica》、《Middle Hua Da pharmacopeia》Deng doctor
Detailed record and description have been carried out to rice dry measure used in former times in learning ancient books and records.
Ginseng：Araliaceae ginseng plantPanax ginsengC. the root of A. Mey, another name wild ginseng, garden ginsent, people's rank,
Terrible lid, wooden club, soil essence, refreshing grass etc..Ginseng has " tonifying five zang organs, soothe the nerves, determine soul, stop palpitate with fear, remove pathogenic factor, the happy intelligence development of improving eyesight "
Effect, " long term usage make light of one's life by commiting suicide macrobiosis ".Li Shizhen (1518-1593 A.D.) exists《Compendium of Materia Medica》In also ginseng is extremely praised highly, it is believed that it " can control male woman one
Cut the chronic diseases marked by deficiency of vital energy ".
Wilsonii：Araliaceae wilsoniiAcanthopanax senticosus (Rupr. et Maxim.)
Harms's is dried root and rhizome.Taste is pungent, hardship, micro-sweet are warm in nature.Return liver warp；Kidney channel.With wines used as antirheumatic, filling liver kidney, strengthening the bones and muscles,
The effect of promoting blood circulation arteries and veins, for wind-cold-dampness arthralgia, lumbocrural pain, muscles and bones impotence, be slow in action, body void is thin and weak etc..
The innovative point of the present invention is, 1, a kind of Chinese medicine containing Dendrobidium huoshanness with antifatigue effect proposed by the present invention
Composition is developed under instruction of Chinese Medicine theory.Which is a kind of Chinese medicine compound prescription with antifatigue effect.2nd, the present invention is carried
Go out it is a kind of have the Chinese medicine composition of antifatigue effect to toiling away containing Dendrobidium huoshanness, the insufficiency of both the spleen and the kindey, body void are weak, appetite
It is depressed to be significantly improved and therapeutic action, it is adaptable to which that long-term body void is weak, not peaceful, soreness of waist and knee joint, the insomnia of poor appetite, the rhythm of the heart
Dreaminess and neurasthenia gravis etc..3rd, the present invention is based on theory of traditional Chinese medical science, theoretical according to traditional tcm health preserving and health care, essence
Rare Chinese medicine and common Chinese are selected, is combined by ratio of weight and the number of copies, extract elite therein, be obtained and be conducive to having for health
The Chinese medicine composition of antifatigue effect, its scientific formula, proportioning are appropriate, preparation method is simple, are easy to operation：4th, the present invention is proposed
Containing Dendrobidium huoshanness have antifatigue effect Chinese medicine composition preparation method be applied to large-scale industrial production.
It is an advantage of the invention that have containing Dendrobidium huoshanness the Chinese medicine composition of antifatigue effect component is appropriate, proportioning is closed
Reason, with good antifatigue effect, with good health-care effect, to toiling away, the insufficiency of both the spleen and the kindey, body void be weak, appetite
It is depressed to be significantly improved and therapeutic action, it is adaptable to which that long-term body void is weak, not peaceful, soreness of waist and knee joint, the insomnia of poor appetite, the rhythm of the heart
The disease such as dreaminess and neurasthenia gravis.Preparation method of the invention is simple, convenient to carry out and operates, it is adaptable to heavy industrialization
Production.
Specific embodiment
Below, technology according to the present invention solution describes embodiments of the invention in detail.
The Chinese medicine composition for having antifatigue effect containing Dendrobidium huoshanness tool proposed by the present invention, using Chinese medicine, by weight
Portion rate is combined, and the Chinese medicine of employing includes Dendrobidium huoshanness, ginseng, wilsonii；The Dendrobidium huoshanness that combines by ratio of weight and the number of copies, people
Ginseng, wilsonii constitute Chinese medicine composition.
The Dendrobidium huoshanness that combines by ratio of weight and the number of copies, ginseng, the respective parts by weight of wilsonii are：Dendrobidium huoshanness 1～5
Part, 2～6 parts of ginseng, 1～3 part of wilsonii.In 1～5 part of Dendrobidium huoshanness, 2～6 parts of ginseng, 1～3 part of wilsonii can be selected
In the range of, applicant propose priority scheme be combine by ratio of weight and the number of copies Dendrobidium huoshanness, ginseng, the respective weight of wilsonii
Number is：3 parts of Dendrobidium huoshanness, 4 parts of ginseng, 2 parts of wilsonii.
The preparation method of the Chinese medicine composition for having antifatigue effect containing Dendrobidium huoshanness tool, by the ratio of weight and number choosing for determining
Chinese medicine is selected, the Chinese medicine to selecting is processed, and obtains Chinese medicine composition.The Chinese medicine for selecting by ratio of weight and the number of copies is Huoshan
The stem of noble dendrobium, ginseng, wilsonii；To the method that the Chinese medicine for selecting is processed it is, by the Chinese medicine Dendrobidium huoshanness for choosing, people
Ginseng, wilsonii are mixed, and add etoh solvent to make mixed liquor, using the method for refluxing extraction, to dissolution in mixed liquor
Pharmaceutical compositions extracted, have the extract of medical value in obtaining mixed liquor, filter off the dregs of a decoction, extract is processed,
Obtain Chinese medicine composition；The Chinese medicine composition for obtaining is the Chinese medicine composition containing Dendrobidium huoshanness, ginseng and wilsonii pharmaceutical compositions；
Step includes：
Step 1, selects Chinese medicine material：Dendrobidium huoshanness, ginseng, wilsonii are weighed in proportion；
Step 2, produces mixed liquor：After the mixing of Dendrobidium huoshanness, ginseng, the fruit of Chinese wolfberry and Momordica grosvenori will be weighed, appropriate 60% ethanol is added
Mixed liquor is made, companion is fully stirred to medicine in mixed liquor, improve the liquor strength of drug-eluting in mixed liquor；
Step 3, refluxing extraction：Using the method for refluxing extraction, the mixed liquor produced to step 2 carries out refluxing extraction, will mixing
Liquid refluxing extraction 2 times, 2～3 hours every time, filters off the dregs of a decoction；
Step 4, is processed to extract：The extract of 2 extractions in combining step 3, the extract to merging reduce pressure
Concentration, and it is spray-dried, dried powder is obtained, dried powder is sieved, obtained containing Dendrobidium huoshanness, ginseng and wilsonii medicine
The Chinese medicine composition of composition.
The concentration of the etoh solvent added in step 2 is 60%.
Using the Chinese medicine preparation that the present invention makes：It is a kind of by containing Dendrobidium huoshanness the Chinese medicine composition with antifatigue effect
Made by Chinese medicine preparation, including pharmaceutical auxiliary material, using the Chinese medicine composition with antifatigue effect containing Dendrobidium huoshanness, according to
Preparation needs, and is equipped with the ratio for determining a certain amount of pharmaceutical in the Chinese medicine composition of the antifatigue effect containing Dendrobidium huoshanness
Auxiliary material, makes the Chinese medicine preparation with antifatigue effect.
Made by there is the Chinese medicine preparation of antifatigue effect to be sustained release agent in medical common formulations, granule, capsule, drop
Ball, tablet, oral liquid.Can also according to specific needs, made by there is the Chinese medicine preparation of antifatigue effect to be the conventional agent of medicine
It is a kind of in sustained release agent, granule, capsule, dripping pill, tablet, oral liquid in type.
It is proposed by the present invention to there is the ginseng that the Chinese medicine composition of antifatigue effect is adopted to include with ginseng containing Dendrobidium huoshanness
For raw material, through medicine materical crude slice obtained in different concocting methods, such as red ginseng, sun-dried ginseng, sugared ginseng etc..
Example 1：There is containing Dendrobidium huoshanness the capsule of antifatigue effect using present invention making.
By determine ratio of weight and number select Chinese medicine, select Chinese medicine Chinese medicine be Dendrobidium huoshanness,（It is obtained by ginseng
's）Red ginseng and wilsonii.Wherein, 60 grams of Dendrobidium huoshanness,（By obtained in ginseng）80 grams of red ginseng, 40 grams of wilsonii.Will be by true
Fixed ratio of weight and number select Chinese medicine Dendrobidium huoshanness,（By obtained in ginseng）Red ginseng and wilsonii mixing, add 10 after mixing
60% ethanol of amount constitutes mixed liquor again, and the mixed liquor to constituting is processed using the method for refluxing extraction, the mixed liquor that will be constituted
Refluxing extraction 2 times, extract mixed liquor in institute's dissolution Dendrobidium huoshanness,（By obtained in ginseng）Red ginseng and wilsonii pharmaceutical compositions,
There is the extract of medical value in obtaining mixed liquor, 3 hours every time, filter off the dregs of a decoction, it is dense that the extract that merging is 2 times carries out decompression
Contracting, it is and spray-dried, obtain dried powder, sieve, obtain containing Dendrobidium huoshanness,（By obtained in ginseng）Red ginseng and wilsonii
The Chinese medicine composition of pharmaceutical compositions.Containing Dendrobidium huoshanness,（By obtained in ginseng）The Chinese medicine group of red ginseng and wilsonii pharmaceutical compositions
Compound is used as the medicinal raw material for making the capsule containing Dendrobidium huoshanness antifatigue effect.Make containing Dendrobidium huoshanness antifatigue effect
During capsule, containing Dendrobidium huoshanness,（By obtained in ginseng）Add in the Chinese medicine composition of red ginseng and wilsonii pharmaceutical compositions
A certain amount of pharmaceutical auxiliary material, the pharmaceutical auxiliary material of addition is magnesium stearate, and the addition of magnesium stearate is making raw material gross weight
Amount 3%, after 200 mesh sieves, loads the medical common formulations capsule that capsule makes the Chinese medicine preparation with antifatigue effect
Agent.The capsule is Chinese medicine preparation made by the Chinese medicine composition with antifatigue effect containing Dendrobidium huoshanness, and which is to long-term labor
The tired, insufficiency of both the spleen and the kindey, body void are weak, poor appetite is significantly improved and therapeutic action, it is adaptable to long-term body void is weak, appetite not
Shake, the rhythm of the heart is peaceful, soreness of waist and knee joint, insomnia and dreamful sleep and neurasthenia gravis etc..
Example 2：There is containing Dendrobidium huoshanness the tablet of antifatigue effect using present invention making
It is the same manner as in Example 1, by determine ratio of weight and number select Chinese medicine, select Chinese medicine Chinese medicine be Dendrobidium huoshanness,
（By obtained in ginseng）Red ginseng and wilsonii.Wherein, 30 grams of Dendrobidium huoshanness,（By obtained in ginseng）40 grams of red ginseng, wilsonii
20 grams.By by determine ratio of weight and number select Dendrobidium huoshanness,（By obtained in ginseng）Red ginseng and wilsonii mixing, after mixing
Add 15 times of 60% ethanol of amount to constitute mixed liquor, processed using the method for refluxing extraction to constituting mixed liquor, refluxing extraction 2
It is secondary, extract mixed liquor in institute's dissolution Dendrobidium huoshanness,（By obtained in ginseng）Red ginseng and wilsonii pharmaceutical compositions, are extracted
Liquid, 3 hours every time, filters off the dregs of a decoction, merges the extract of 2 times, reduce pressure dense and spray-dried, obtain dried powder, sieve, obtain
To containing Dendrobidium huoshanness,（By obtained in ginseng）The Chinese medicine composition of red ginseng and wilsonii pharmaceutical compositions.Containing Dendrobidium huoshanness,（By people
Ginseng is obtained）The Chinese medicine composition of red ginseng and wilsonii pharmaceutical compositions is used as tablet of the making containing Dendrobidium huoshanness antifatigue effect
Medicinal raw material.Make containing Dendrobidium huoshanness antifatigue effect tablet when, containing Dendrobidium huoshanness,（By obtained in ginseng）Red ginseng
With add appropriate microcrystalline cellulose in the Chinese medicine composition of wilsonii pharmaceutical compositions, cross 200 mesh sieves, granulation is tabletted
Agent.The tablet is Chinese medicine preparation made by the Chinese medicine composition with antifatigue effect containing Dendrobidium huoshanness.Its to toiling away,
The insufficiency of both the spleen and the kindey, body void be weak, poor appetite is significantly improved and therapeutic action, it is adaptable to long-term body void is weak, poor appetite,
The rhythm of the heart is peaceful, soreness of waist and knee joint, insomnia and dreamful sleep and neurasthenia gravis etc..
Example 3：There is containing Dendrobidium huoshanness the granule of antifatigue effect using present invention making
With example 1 as example 2, Chinese medicine is selected by the ratio of weight and number for determining, the Chinese medicine for selecting Chinese medicine is Huoshan
The stem of noble dendrobium,（By obtained in ginseng）Red ginseng and wilsonii.Wherein, 90 grams of Dendrobidium huoshanness,（By obtained in ginseng）110 grams of red ginseng,
70 grams of wilsonii, the Dendrobidium huoshanness that the ratio of weight and number by determination is selected,（By obtained in ginseng）Red ginseng and wilsonii mixing,
10 times of 60% ethanol of amount are added to constitute mixed liquor after mixing, the mixed liquor to constituting is processed using the method for refluxing extraction, will
Mixed-liquor return is extracted 2 times, 3 hours every time, is filtered off the dregs of a decoction, is merged the extract of 2 times, extract is carried out reduced pressure concentration, and
It is spray-dried, obtain dried powder, sieve, obtain containing Dendrobidium huoshanness,（By obtained in ginseng）Red ginseng and wilsonii medicine into
The Chinese medicine composition of part.Containing Dendrobidium huoshanness,（By obtained in ginseng）The Chinese medicine composition conduct of red ginseng and wilsonii pharmaceutical compositions
Make the medicinal raw material of the granule containing Dendrobidium huoshanness antifatigue effect.Make the granule containing Dendrobidium huoshanness antifatigue effect
When, will containing Dendrobidium huoshanness,（By obtained in ginseng）The Chinese medicine composition of red ginseng and wilsonii pharmaceutical compositions crosses 200 mesh sieves, plus
Enter appropriate sucrose, pelletize, that is, the granule containing Dendrobidium huoshanness antifatigue effect required for being fabricated to.The granule is containing suddenly
Chinese medicine preparation made by the Chinese medicine composition with antifatigue effect of the mountain stem of noble dendrobium.Which is to toiling away, the insufficiency of both the spleen and the kindey, body void are weary
Power, poor appetite are significantly improved and therapeutic action, it is adaptable to which long-term body void is weak, not peaceful, the waist and knee acid of poor appetite, the rhythm of the heart
Bitterly, insomnia and dreamful sleep and neurasthenia gravis etc..
Zoopery is done using the Chinese medicine composition with antifatigue effect containing Dendrobidium huoshanness of the present invention, mouse is filled
Stomach, to mouse using the existence under the conditions of after the Chinese medicine composition 7 days, investigating the swimming with a load attached to the body of mouse, oxygen deficit tolerance respectively
Time and mouse anti-reflecting fatigue are run experiment.Applicant reed is known, the Chinese medicine with antifatigue effect containing Dendrobidium huoshanness of the present invention
Composition can significantly extend mice burden swimming time (P<0.05) life span (P that, can be obviously prolonged under the conditions of anoxia in mice
<0.05).Run in experiment in mouse anti-reflecting fatigue, run distance (P of the mouse on cycle type fatigue instrument can be obviously prolonged<
0.05).Experiment shows that the Chinese medicine composition with antifatigue effect containing Dendrobidium huoshanness of the present invention has antifatigue, resistance to lacking
Oxygen is acted on, and is a kind of effectively antifatigue Chinese medicine composition.
The above embodiment of the present invention technology design only to illustrate the invention and the bare bones of the present invention are realized, its mesh
Be to allow understand that those skilled in the art of the technology of the present invention solution will appreciate that the present invention covers technology contents, and
Implement according to this, the protection domain that technical solution proposed by the present invention covers can not be limited with this.It is all according to the present invention
The equivalent transformation done by the substantial technological content of proposition should be all included within the scope of the present invention into modification.
Claims (4)
1. the Chinese medicine composition for having antifatigue effect containing Dendrobidium huoshanness tool, using Chinese medicine, is combined by ratio of weight and the number of copies, and which is special
Levy and be, the Chinese medicine of employing includes Dendrobidium huoshanness, ginseng, wilsonii；The Dendrobidium huoshanness that combines by ratio of weight and the number of copies, ginseng,
Wilsonii constitutes Chinese medicine composition.
2. it is according to claim 1 containing Dendrobidium huoshanness tool the Chinese medicine composition for having antifatigue effect, it is characterised in that press
The Dendrobidium huoshanness of ratio of weight and number combination, ginseng, the respective parts by weight of wilsonii are：1～5 part of Dendrobidium huoshanness, ginseng 2～6
Part, 1～3 part of wilsonii.
3. it is according to claim 1 containing Dendrobidium huoshanness tool the Chinese medicine composition for having antifatigue effect, it is characterised in that press
The Dendrobidium huoshanness of ratio of weight and number combination, ginseng, the respective parts by weight of wilsonii are：3 parts of Dendrobidium huoshanness, 4 parts of ginseng, thorn five
Plus 2 parts.
4. the preparation method of the Chinese medicine composition for having antifatigue effect containing Dendrobidium huoshanness tool, is selected by the ratio of weight and number for determining
Chinese medicine, the Chinese medicine to selecting are processed, and obtain Chinese medicine composition, it is characterised in that select Chinese medicine by ratio of weight and the number of copies
Material is Dendrobidium huoshanness, ginseng, wilsonii；It is that the Chinese medicine for choosing is mixed to the method that the Chinese medicine for selecting is processed
Together, add etoh solvent to make mixed liquor, using the method for refluxing extraction, the pharmaceutical compositions of dissolution in mixed liquor are carried out
Extract, in obtaining mixed liquor, have the extract of medical value, filter off the dregs of a decoction, extract is processed, Chinese traditional medicine composition is obtained
Thing；It is the Chinese medicine composition containing Dendrobidium huoshanness, ginseng and wilsonii pharmaceutical compositions to obtain Chinese medicine composition；Step includes：
Step 1, selects Chinese medicine material：Dendrobidium huoshanness, ginseng, wilsonii are weighed in proportion；
Step 2, produces mixed liquor：After the mixing of Dendrobidium huoshanness, ginseng, the fruit of Chinese wolfberry and Momordica grosvenori will be weighed, appropriate ethanol is added
Mixed liquor is made, companion is fully stirred to medicine in mixed liquor, improve the liquor strength of drug-eluting in mixed liquor；
Step 3, refluxing extraction：Using the method for refluxing extraction, the mixed liquor produced to step 2 carries out refluxing extraction, will mixing
Liquid refluxing extraction 2 times, 2～3 hours every time, filters off the dregs of a decoction；
Step 4, is processed to extract：The extract of 2 extractions in combining step 3, the extract to merging reduce pressure
Concentration, and it is spray-dried, dried powder is obtained, dried powder is sieved, obtained containing Dendrobidium huoshanness, ginseng and wilsonii medicine
The Chinese medicine composition of composition.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611053456.XA CN106511777A (en) | 2016-11-25 | 2016-11-25 | Dendrobium huoshanense-containing traditional Chinese medicinal composition having anti-fatigue effect, and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611053456.XA CN106511777A (en) | 2016-11-25 | 2016-11-25 | Dendrobium huoshanense-containing traditional Chinese medicinal composition having anti-fatigue effect, and preparation method thereof |
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| CN106511777A true CN106511777A (en) | 2017-03-22 |
Family
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| CN201611053456.XA Withdrawn CN106511777A (en) | 2016-11-25 | 2016-11-25 | Dendrobium huoshanense-containing traditional Chinese medicinal composition having anti-fatigue effect, and preparation method thereof |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107874255A (en) * | 2017-11-13 | 2018-04-06 | 吉林省瑞草园科技有限公司 | A kind of ginseng is base source health food for relieving physical fatigue and preparation method thereof |
| CN108514111A (en) * | 2018-03-05 | 2018-09-11 | 安徽省霍山县福康石斛开发有限公司 | A kind of preparation method of nourishing blood and liver stem of noble dendrobium cake |
| CN113080455A (en) * | 2021-05-10 | 2021-07-09 | 皖西学院 | Dendrobium huoshanense and red ginseng oral liquid as well as preparation process and application thereof |
| CN115517309A (en) * | 2022-02-10 | 2022-12-27 | 孙栋梁 | Three-ingredient health tea and preparation method thereof |
-
2016
- 2016-11-25 CN CN201611053456.XA patent/CN106511777A/en not_active Withdrawn
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107874255A (en) * | 2017-11-13 | 2018-04-06 | 吉林省瑞草园科技有限公司 | A kind of ginseng is base source health food for relieving physical fatigue and preparation method thereof |
| CN108514111A (en) * | 2018-03-05 | 2018-09-11 | 安徽省霍山县福康石斛开发有限公司 | A kind of preparation method of nourishing blood and liver stem of noble dendrobium cake |
| CN113080455A (en) * | 2021-05-10 | 2021-07-09 | 皖西学院 | Dendrobium huoshanense and red ginseng oral liquid as well as preparation process and application thereof |
| CN115517309A (en) * | 2022-02-10 | 2022-12-27 | 孙栋梁 | Three-ingredient health tea and preparation method thereof |
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Application publication date: 20170322 |
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