CN103341049A - Dendrobium huoshanense-containing traditional Chinese medicine composition with anti-fatigue effect, and preparation method thereof - Google Patents
Dendrobium huoshanense-containing traditional Chinese medicine composition with anti-fatigue effect, and preparation method thereof Download PDFInfo
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Abstract
The invention relates to a dendrobium huoshanense-containing traditional Chinese medicine composition with an anti-fatigue effect, and a preparation method thereof. The traditional Chinese medicine composition is used for preparing traditional Chinese medicine preparations. The dendrobium huoshanense-containing traditional Chinese medicine composition with the anti-fatigue effect is formed by using traditional Chinese medicinal materials comprising dendrobium huoshanense, ginseng and manyprickle acathopanax root as raw materials according to determined proportions by weight. The preparation method of the dendrobium huoshanense-containing traditional Chinese medicine composition with the anti-fatigue effect comprises the steps of selecting the traditional Chinese medicinal materials according to the determined proportions by weight; and processing the selected traditional Chinese medicinal materials to obtain the traditional Chinese medicine composition. The traditional Chinese medicinal materials selected according to the determined proportions by weight are dendrobium huoshanense, ginseng and manyprickle acathopanax root; and the processing method for the traditional Chinese medicinal materials comprises the steps of mixing the selected traditional Chinese medicinal materials; adding a solvent ethanol to make a mixed solution; extracting dissolved out medicine components from the mixed solution by a refluxing extraction method; acquiring an extract liquid with pharmaceutical value from the mixed solution; filtering medicine residues; and treating the extract liquid to obtain the traditional Chinese medicine composition.
Description
Technical field
The invention belongs to medicine and health product technology field, be specifically related to a kind of Chinese medicine composition and preparation method thereof, what particularly contain Herba Dendrobii has Chinese medicine composition of antifatigue effect and preparation method thereof.The present invention for the preparation of have antifatigue effect product, comprise medicine and health product.
Background technology
Along with the quickening of modern life rhythm and the aggravation of social competition, a lot of people make physical condition doubly influenced because the pressure of aspects such as work, study and dinner party causes excessively overdrawing health, according to the knowledge of the applicant, physical fatigue is becoming the practical problem of a lot of people's health of puzzlement.
According to the interrelated data introduction, fatigue refers to that the organism physiology process can not continue its function maybe can not maintain specific exercise intensity on specified level physiological reaction, this physiological reaction can appear on a plurality of organs of body, and at many organs, many tissues, in multi-level complicated variation can take place, and may also can be with mental change, fatigue belongs to the sub-health state category.In the Chinese medicine books, fatigue there are " asthenia ", " slacking off ", " slack lazy ", " extremity overstrain " and descriptions such as " inability to raise the limbss ".The treatment method of fatigue is had multiple, mainly be medicine auxiliary treatment, food auxiliary treatment and strengthen physical exercise.
At present, the anti-fatigue product on the market roughly can be divided into following a few class:
1, makeup energy reaches the purpose of keeping body normal physiological function, fatigue alleviating by the trophic factors that replenishes health consumption.
2, replenish vitamin and the trace element of needed by human.
3, by improving and improve the function of body, rebuild the poised state of body, removing and the discharge of acceleration bodies intracellular metabolite material reach the resisting fatigue purpose.
A lot of Chinese medicine preparation all belong to the 3rd series products.
Existing anti-fatigue health-product containing on the market, kind is more, and action effect has nothing in common with each other, and quality is also uneven.According to the knowledge of the applicant, there is certain problem in some anti-fatigue health-caring product, and its curative effect awaits further checking.
Summary of the invention
The objective of the invention is, have deficiency at prior art, improve, proposition and research contain Herba Dendrobii and have compound preparation of antifatigue effect and preparation method thereof.
Technical solution of the present invention is: contain the Chinese medicine composition that antifatigue effect is arranged of Herba Dendrobii tool, adopt Chinese crude drug, combination is characterized in that the Chinese crude drug of employing comprises Herba Dendrobii, Radix Ginseng, Radix Et Caulis Acanthopanacis Senticosi by ratio of weight and the number of copies; Zu He Herba Dendrobii, Radix Ginseng, Radix Et Caulis Acanthopanacis Senticosi constitute Chinese medicine composition by ratio of weight and the number of copies.
It is characterized in that Zu He Herba Dendrobii, Radix Ginseng, Radix Et Caulis Acanthopanacis Senticosi parts by weight separately are by ratio of weight and the number of copies: 1 ~ 5 part of Herba Dendrobii, 2 ~ 6 parts of Radix Ginsengs, 1 ~ 3 part of Radix Et Caulis Acanthopanacis Senticosi.
It is characterized in that Zu He Herba Dendrobii, Radix Ginseng, Radix Et Caulis Acanthopanacis Senticosi parts by weight separately are by ratio of weight and the number of copies: 3 parts of Herba Dendrobii, 4 parts of Radix Ginsengs, 2 parts of Radix Et Caulis Acanthopanacis Senticosis.
The preparation method that contains the Chinese medicine composition that antifatigue effect is arranged of Herba Dendrobii tool, select Chinese crude drug by the ratio of weight and number of determining, the Chinese crude drug of selecting is processed, obtain Chinese medicine composition, it is characterized in that selecting Chinese crude drug by ratio of weight and the number of copies is Herba Dendrobii, Radix Ginseng, Radix Et Caulis Acanthopanacis Senticosi; The Chinese crude drug of selecting is carried out method for processing is, the Chinese crude drug that chooses is mixed, add etoh solvent and make mixed liquor, adopt the method for reflux, extract,, pharmaceutical compositions to stripping in the mixed liquor extracts, and obtains the extracting solution that medical value is arranged in the mixed liquor, the elimination medicinal residues, extracting solution is handled, obtained Chinese medicine composition; The Chinese medicine composition that obtains is the Chinese medicine composition that contains Herba Dendrobii, Radix Ginseng, Radix Et Caulis Acanthopanacis Senticosi pharmaceutical compositions; Step comprises:
Step 1 is selected Chinese crude drug: take by weighing Herba Dendrobii, Radix Ginseng, Radix Et Caulis Acanthopanacis Senticosi in proportion;
Step 2 is produced mixed liquor: after will taking by weighing Herba Dendrobii, Radix Ginseng, Radix Et Caulis Acanthopanacis Senticosi mixing in proportion, add etoh solvent and make mixed liquor, the medicine in the mixed liquor is fully stirred the companion, improve the liquor strength of mixed liquor Chinese medicine stripping;
Step 3, reflux, extract: adopt the method for reflux, extract,, the mixed liquor that step 2 is produced carries out reflux, extract,, mixed-liquor return extracted 2 times, each 2 ~ 3 hours, the elimination medicinal residues;
Step 4, extracting solution is handled: the extracting solution that 2 times are extracted in the combining step 3, the extracting solution that is combined carries out concentrating under reduced pressure, and it is spray-dried, obtain dried powder, dried powder is sieved, obtain containing the Chinese medicine composition of Herba Dendrobii, Radix Ginseng and Radix Et Caulis Acanthopanacis Senticosi pharmaceutical compositions.
It is characterized in that the concentration of the etoh solvent that adds in the step 2 is 60%.
A kind of Chinese medicine preparation of being made by the Chinese medicine composition with antifatigue effect that contains Herba Dendrobii, comprise pharmaceutical adjuvant, it is characterized in that, employing contains the Chinese medicine composition with antifatigue effect of Herba Dendrobii, according to the preparation needs, in the Chinese medicine composition of the antifatigue effect that contains Herba Dendrobii, be equipped with a certain amount of pharmaceutical adjuvant in the ratio of determining, make the Chinese medicine preparation with antifatigue effect.
It is characterized in that the Chinese medicine preparation made from antifatigue effect is slow releasing agent, granule, capsule, drop pill, tablet, the oral liquid in the medical common formulations.
It is characterized in that the Chinese medicine preparation made from antifatigue effect is a kind of in the slow releasing agent, granule, capsule, capsule, tablet, oral liquid in the medical common formulations.
The Ji Yuan of Chinese medicine (Herba Dendrobii, Radix Ginseng, the Radix Et Caulis Acanthopanacis Senticosi) each component that the present invention adopts and medicinal, health care is as follows:
Herba Dendrobii: Herba Dendrobii be the orchid family Dendrobium (
Dendrobium) herbaceos perennial, be China's tradition rare Chinese medicine, all on the books in many classic medical books such as Shennong's Herbal, " Taoist Scriptures ", Compendium of Material Medica, " preemergency a thousand pieces of gold prescription ".According to successive dynasties book on Chinese herbal medicine record as can be known, Herba Dendrobii has nourishing YIN and clearing away heat, the stomach reinforcing that promotes the production of body fluid, wet one's whistle make eye bright, life lengthening ground, tonifying five ZANG-organs asthenia sea is thin, reinforcing YIN-essence and remove the effect of deficiency-heat etc.Wherein, in " road a surname " book, the Poria of Herba Dendrobii and Herba Saussureae Involueratae, three liang of Radix Ginsengs, 120 years Radixs Polygoni Multiflori, cycle of sixty years, Herba Cistanches, remote mountains Ganoderma, seabed Margarita, Cordyceps etc. are classified as China's " nine big Herba mesonae chinensis ", and be listed in first of China's nine big Herba mesonae chinensis.
Modern medicine study shows that the active component of Herba Dendrobii mainly contains chemical constituents such as alkaloid, aminoacid and polysaccharide.Relevant pharmacological research confirms, Herba Dendrobii improve human body immunity, defying age, antitumor, improve diabetic symptom, there is significant curative effect aspects such as treatment atrophic gastritis, particularly in recent years for side effect and restore funcitons aspect after elimination cancer radiation, the chemotherapy, effect is fairly obvious.
According to the knowledge of the applicant, in all Herba Dendrobii products, be included in the Herba Dendrobii (claiming the rice dry measure used in former times again), Herba Dendrobii and the Dendrobium Moniliforme that produce in Huoshan, Herba Dendrobii the best.Shennong's Herbal record, " Herba Dendrobii is given birth on the other stone of six peace mountain valley water, adopts stem August in July and dries in the shade ", this is to the record the earliest in the Herba Dendrobii place of production and habitat in the successive dynasties book on Chinese herbal medicine.In main three kinds of Herba Dendrobii kinds that produce in Huoshan, Herba Dendrobii (
Dendrobium huoshanenseThe rice dry measure used in former times) the most rare precious, just praised highly to the treasure in the Herba Dendrobii that is used as medicine by doctor family from ancient times, be called as " help Herba mesonae chinensis ", " soft gold ", " plant gold ", in medical science ancient books and records such as Compendium of Material Medica, " the big pharmacopeia of China ", the rice dry measure used in former times has been carried out write up and description.
Radix Ginseng: araliaceae ginseng plant
Panax ginsengC. the root of A. Mey is called SHANSHEN, Park Ginseng, people's rank, Coprinus atramentarius (Bull.) Fr. (Coprinus sterquilinus Fr.), wooden club, Rhizoma Panacis Japonici, SHENCAO etc.Radix Ginseng have " tonifying five ZANG-organs, peace spirit, decide soul, spasmolytic throb with fear, except pathogen, happy Fructus Alpiniae Oxyphyllae makes eye bright " effect, " obey to make light of one's life by commiting suicide for a long time and prolong life ".Li Shizhen (1518-1593 A.D.) is also very praised highly Radix Ginseng in Compendium of Material Medica, thinks that it can " control all deficient syndromes of male woman ".
Radix Et Caulis Acanthopanacis Senticosi: Araliaceae Radix Et Caulis Acanthopanacis Senticosi
Acanthopanax senticosusThe dry root and rhizome of (Rupr. et Maxim.) Harms.Acrid in the mouth, hardship, little sweet, warm in nature.Return Liver Channel; Kidney channel.Have wind-damp dispelling, invigorating the liver and kidney, bone and muscle strengthening, the feeling pulse effect of invigorating blood circulation, be used for anemofrigid-damp arthralgia, lumbocrural pain, muscles and bones flaccidity soft, be slow in action, the body weakness with emaciation is weak etc.
Innovative point of the present invention is, 1, the present invention propose a kind of to contain the Chinese medicine composition that Herba Dendrobii has antifatigue effect be to develop under instruction of Chinese Medicine theory.It is a kind of Chinese medicine compound with antifatigue effect.2, the present invention propose a kind of contain Chinese medicine composition that Herba Dendrobii has an antifatigue effect to toil away, deficiency of spleen-YANG and kidneyYANG, body void are weak, inappetence has significant improvement and therapeutical effect, are applicable to that long-term body void is weak, inappetence, the rhythm of the heart are peaceful, soreness of waist and knee joint, insomnia and dreamful sleep and neurasthenia gravis etc.3, the present invention is based on theory of Chinese medical science, theoretical according to traditional tcm health preserving and health care, selected rare Chinese medicine and common Chinese, combination by ratio of weight and the number of copies, extract elite wherein, make the Chinese medicine composition with antifatigue effect that is conducive to health, its prescription science, proportioning is appropriate, preparation method is simple, is convenient to operation: 4, the present invention proposes contains the preparation method that Herba Dendrobii has the Chinese medicine composition of antifatigue effect and is applicable to large-scale industrial production.
Advantage of the present invention is, contain appropriate, the reasonable mixture ratio of Chinese medicinal composition that Herba Dendrobii has antifatigue effect, has good antifatigue effect, has good health-care effect, to toil away, deficiency of spleen-YANG and kidneyYANG, body void are weak, inappetence has significant improvement and therapeutical effect, are applicable to that long-term body void is weak, diseases such as inappetence, the rhythm of the heart are peaceful, soreness of waist and knee joint, insomnia and dreamful sleep and neurasthenia gravis.Preparation method of the present invention is simple, be convenient to implement and operation, is applicable to large-scale industrial production.
The specific embodiment
Below, describe embodiments of the invention in detail according to technical solution of the present invention.
The Chinese medicine composition that antifatigue effect is arranged that contains the Herba Dendrobii tool that the present invention proposes adopts Chinese crude drug, combination by ratio of weight and the number of copies, and the Chinese crude drug of employing comprises Herba Dendrobii, Radix Ginseng, Radix Et Caulis Acanthopanacis Senticosi; Zu He Herba Dendrobii, Radix Ginseng, Radix Et Caulis Acanthopanacis Senticosi constitute Chinese medicine composition by ratio of weight and the number of copies.
Zu He Herba Dendrobii, Radix Ginseng, Radix Et Caulis Acanthopanacis Senticosi parts by weight separately are by ratio of weight and the number of copies: 1 ~ 5 part of Herba Dendrobii, 2 ~ 6 parts of Radix Ginsengs, 1 ~ 3 part of Radix Et Caulis Acanthopanacis Senticosi.1 ~ 5 part of Herba Dendrobii, 2 ~ 6 parts of Radix Ginsengs, 1 ~ 3 part of Radix Et Caulis Acanthopanacis Senticosi can the range of choice in, the applicant proposes priority scheme, Zu He Herba Dendrobii, Radix Ginseng, Radix Et Caulis Acanthopanacis Senticosi parts by weight separately are by ratio of weight and the number of copies: 3 parts of Herba Dendrobii, 4 parts of Radix Ginsengs, 2 parts of Radix Et Caulis Acanthopanacis Senticosis.
The preparation method that contains the Chinese medicine composition that antifatigue effect is arranged of Herba Dendrobii tool is selected Chinese crude drug by the ratio of weight and number of determining, the Chinese crude drug of selecting is processed, and obtains Chinese medicine composition.The Chinese crude drug of Xuan Zeing is Herba Dendrobii, Radix Ginseng, Radix Et Caulis Acanthopanacis Senticosi by ratio of weight and the number of copies; The Chinese crude drug of selecting is carried out method for processing is, the Chinese crude drug Herba Dendrobii, Radix Ginseng, the Radix Et Caulis Acanthopanacis Senticosi that choose are mixed, add etoh solvent and make mixed liquor, adopt the method for reflux, extract,, pharmaceutical compositions to stripping in the mixed liquor extracts, and obtains the extracting solution that medical value is arranged in the mixed liquor, the elimination medicinal residues, extracting solution is handled, obtained Chinese medicine composition; The Chinese medicine composition that obtains is the Chinese medicine composition that contains Herba Dendrobii, Radix Ginseng and Radix Et Caulis Acanthopanacis Senticosi pharmaceutical compositions; Step comprises:
Step 1 is selected raw material of Chinese medicine: take by weighing Herba Dendrobii, Radix Ginseng, Radix Et Caulis Acanthopanacis Senticosi in proportion;
Step 2 is produced mixed liquor: after will taking by weighing Herba Dendrobii, Radix Ginseng, Fructus Lycii and Fructus Momordicae mixing, add an amount of 60% ethanol and make mixed liquor, the mixed liquor Chinese medicine is fully stirred the companion, improve the liquor strength of mixed liquor Chinese medicine stripping;
Step 3, reflux, extract: adopt the method for reflux, extract,, the mixed liquor that step 2 is produced carries out reflux, extract,, mixed-liquor return extracted 2 times, each 2 ~ 3 hours, the elimination medicinal residues;
Step 4, extracting solution is handled: the extracting solution that 2 times are extracted in the combining step 3, the extracting solution that is combined carries out concentrating under reduced pressure, and it is spray-dried, obtain dried powder, dried powder is sieved, obtain containing the Chinese medicine composition of Herba Dendrobii, Radix Ginseng and Radix Et Caulis Acanthopanacis Senticosi pharmaceutical compositions.
The concentration of the etoh solvent that adds in the step 2 is 60%.
Use the Chinese medicine preparation that the present invention makes: a kind of Chinese medicine preparation of being made by the Chinese medicine composition with antifatigue effect that contains Herba Dendrobii, comprise pharmaceutical adjuvant, employing contains the Chinese medicine composition with antifatigue effect of Herba Dendrobii, according to the preparation needs, in the Chinese medicine composition of the antifatigue effect that contains Herba Dendrobii, be equipped with a certain amount of pharmaceutical adjuvant in the ratio of determining, make the Chinese medicine preparation with antifatigue effect.
The Chinese medicine preparation made from antifatigue effect is slow releasing agent, granule, capsule, drop pill, tablet, the oral liquid in the medical common formulations.Also can be according to concrete needs, the Chinese medicine preparation made from antifatigue effect is a kind of in the slow releasing agent, granule, capsule, drop pill, tablet, oral liquid in the medical common formulations.
The present invention proposes contains the Radix Ginseng that Chinese medicine composition that Herba Dendrobii has antifatigue effect adopts and comprises with the Radix Ginseng being raw material, and the decoction pieces that makes through different concocting methods is as Radix Ginseng Rubra, Radix Ginseng, Radix Ginseng (processed with sugar) etc.
Example 1: use the present invention's making and contain the capsule that Herba Dendrobii has antifatigue effect.
Select Chinese crude drug by the ratio of weight and number of determining, selecting the Chinese crude drug of Chinese crude drug is Herba Dendrobii, (being made by Radix Ginseng) Radix Ginseng Rubra and Radix Et Caulis Acanthopanacis Senticosi.Wherein, Herba Dendrobii 60 grams, (being made by Radix Ginseng) Radix Ginseng Rubra 80 grams, Radix Et Caulis Acanthopanacis Senticosi 40 grams.To select the Chinese crude drug Herba Dendrobii by the ratio of weight and number of determining, (being made by Radix Ginseng) Radix Ginseng Rubra and Radix Et Caulis Acanthopanacis Senticosi mix, mix the back and add 10 times of amount 60% ethanol formation mixed liquors, adopt the method for reflux, extract, to handle to the mixed liquor that constitutes, the mixed-liquor return that constitutes is extracted 2 times, extract the Herba Dendrobii of institute's stripping in the mixed liquor, (being made by Radix Ginseng) Radix Ginseng Rubra and Radix Et Caulis Acanthopanacis Senticosi pharmaceutical compositions, obtain to have in the mixed liquor extracting solution of medical value, each 3 hours, the elimination medicinal residues, the extracting solution that merges 2 times carries out concentrating under reduced pressure, and it is spray-dried, obtain dried powder, sieve, obtain containing Herba Dendrobii, the Chinese medicine composition of (being made by Radix Ginseng) Radix Ginseng Rubra and Radix Et Caulis Acanthopanacis Senticosi pharmaceutical compositions.The Chinese medicine composition that contains Herba Dendrobii, (being made by Radix Ginseng) Radix Ginseng Rubra and Radix Et Caulis Acanthopanacis Senticosi pharmaceutical compositions contains the medicinal raw material of the capsule of Herba Dendrobii antifatigue effect as making.When making contains the capsule of Herba Dendrobii antifatigue effect, in the Chinese medicine composition that contains Herba Dendrobii, (being made by Radix Ginseng) Radix Ginseng Rubra and Radix Et Caulis Acanthopanacis Senticosi pharmaceutical compositions, add a certain amount of pharmaceutical adjuvant
,The pharmaceutical adjuvant that adds is magnesium stearate, and the addition of magnesium stearate after 200 mesh sieves, incapsulates medical common formulations-capsule of namely making the Chinese medicine preparation with antifatigue effect for making raw material gross weight 3%.This capsule is to contain the Chinese medicine preparation that the Chinese medicine composition with antifatigue effect of Herba Dendrobii is made, its to toil away, deficiency of spleen-YANG and kidneyYANG, body void are weak, inappetence has significant improvement and therapeutical effect, are applicable to that long-term body void is weak, inappetence, the rhythm of the heart are peaceful, soreness of waist and knee joint, insomnia and dreamful sleep and neurasthenia gravis etc.
Example 2: use the present invention's making and contain the tablet that Herba Dendrobii has antifatigue effect
The same with embodiment 1, select Chinese crude drug by the ratio of weight and number of determining, selecting the Chinese crude drug of Chinese crude drug is Herba Dendrobii, (being made by Radix Ginseng) Radix Ginseng Rubra and Radix Et Caulis Acanthopanacis Senticosi.Wherein, Herba Dendrobii 30 grams, (being made by Radix Ginseng) Radix Ginseng Rubra 40 grams, Radix Et Caulis Acanthopanacis Senticosi 20 grams.Will be by the Herba Dendrobii of the ratio of weight and number selection of determining, (being made by Radix Ginseng) Radix Ginseng Rubra and Radix Et Caulis Acanthopanacis Senticosi mix, mix the back and add 15 times of amount 60% ethanol formation mixed liquors, adopt the method for reflux, extract, to handle to constituting mixed liquor, reflux, extract, 2 times, extract the Herba Dendrobii of institute's stripping in the mixed liquor, (being made by Radix Ginseng) Radix Ginseng Rubra and Radix Et Caulis Acanthopanacis Senticosi pharmaceutical compositions, obtain extracting solution, each 3 hours, the elimination medicinal residues, merge 2 times extracting solution, it is dense and spray-dried to reduce pressure, and obtains dried powder, sieve, obtain containing Herba Dendrobii, the Chinese medicine composition of (being made by Radix Ginseng) Radix Ginseng Rubra and Radix Et Caulis Acanthopanacis Senticosi pharmaceutical compositions.The Chinese medicine composition that contains Herba Dendrobii, (being made by Radix Ginseng) Radix Ginseng Rubra and Radix Et Caulis Acanthopanacis Senticosi pharmaceutical compositions contains the medicinal raw material of the tablet of Herba Dendrobii antifatigue effect as making.When making contains the tablet of Herba Dendrobii antifatigue effect, in the Chinese medicine composition that contains Herba Dendrobii, (being made by Radix Ginseng) Radix Ginseng Rubra and Radix Et Caulis Acanthopanacis Senticosi pharmaceutical compositions, add an amount of microcrystalline Cellulose, cross 200 mesh sieves, granulate, be pressed into tablet.This tablet is to contain the Chinese medicine preparation that the Chinese medicine composition with antifatigue effect of Herba Dendrobii is made.Its to toil away, deficiency of spleen-YANG and kidneyYANG, body void are weak, inappetence has significant improvement and therapeutical effect, are applicable to that long-term body void is weak, inappetence, the rhythm of the heart are peaceful, soreness of waist and knee joint, insomnia and dreamful sleep and neurasthenia gravis etc.
Example 3: use the present invention's making and contain the granule that Herba Dendrobii has antifatigue effect
The same with example 2 with example 1, select Chinese crude drug by the ratio of weight and number of determining, selecting the Chinese crude drug of Chinese crude drug is Herba Dendrobii, (being made by Radix Ginseng) Radix Ginseng Rubra and Radix Et Caulis Acanthopanacis Senticosi.Wherein, Herba Dendrobii 90 grams, (being made by Radix Ginseng) Radix Ginseng Rubra 110 grams, Radix Et Caulis Acanthopanacis Senticosi 70 grams, will be by the Herba Dendrobii of the ratio of weight and number selection of determining, (being made by Radix Ginseng) Radix Ginseng Rubra and Radix Et Caulis Acanthopanacis Senticosi mix, mix the back and add 10 times of amount 60% ethanol formation mixed liquors, adopt the method for reflux, extract, to handle to the mixed liquor that constitutes, mixed-liquor return is extracted 2 times, each 3 hours, the elimination medicinal residues merge 2 times extracting solution, and extracting solution is carried out concentrating under reduced pressure, and it is spray-dried, obtain dried powder, sieve, obtain containing Herba Dendrobii, the Chinese medicine composition of (being made by Radix Ginseng) Radix Ginseng Rubra and Radix Et Caulis Acanthopanacis Senticosi pharmaceutical compositions.The Chinese medicine composition that contains Herba Dendrobii, (being made by Radix Ginseng) Radix Ginseng Rubra and Radix Et Caulis Acanthopanacis Senticosi pharmaceutical compositions contains the medicinal raw material of the granule of Herba Dendrobii antifatigue effect as making.When making contains the granule of Herba Dendrobii antifatigue effect, the Chinese medicine composition that will contain Herba Dendrobii, (being made by Radix Ginseng) Radix Ginseng Rubra and Radix Et Caulis Acanthopanacis Senticosi pharmaceutical compositions is crossed 200 mesh sieves, add suitable amount of sucrose, granulate, namely be made into the needed granule that contains the Herba Dendrobii antifatigue effect.This granule is to contain the Chinese medicine preparation that the Chinese medicine composition with antifatigue effect of Herba Dendrobii is made.Its to toil away, deficiency of spleen-YANG and kidneyYANG, body void are weak, inappetence has significant improvement and therapeutical effect, are applicable to that long-term body void is weak, inappetence, the rhythm of the heart are peaceful, soreness of waist and knee joint, insomnia and dreamful sleep and neurasthenia gravis etc.
Use the Chinese medicine composition with antifatigue effect that contains Herba Dendrobii of the present invention and do zoopery, to mouse stomach, use this Chinese medicine composition after 7 days to mice, the experiment of running of swimming with a load attached to the body, the life span under the normal pressure anoxia enduring condition and the mouse anti-reflecting fatigue of investigating mice respectively.Applicant Miscanthus sacchariflorus (Maxim) Benth et Hook f is known, and the Chinese medicine composition energy significant prolongation mice swimming with a load attached to the body time (P＜0.05) with antifatigue effect that contains Herba Dendrobii of the present invention, can obviously prolong the life span (P＜0.05) under the anoxia in mice condition.In mouse anti-reflecting fatigue is run experiment, can obviously prolong the run distance (P＜0.05) of mice on the tired instrument of cycle type.Experiment has shown that the Chinese medicine composition with antifatigue effect that contains Herba Dendrobii of the present invention has resisting fatigue, resisting oxygen lack, is a kind of Chinese medicine composition of effective resisting fatigue.
The above embodiment of the present invention is only for illustrating technical conceive of the present invention and realizing bare bones of the present invention; its purpose is to allow those skilled in the art of understanding the technology of the present invention solution can understand the present invention to contain technology contents; and implement according to this, can not limit the protection domain that technical solution that the present invention proposes contains with this.The equivalent transformation that all essence technology contents that proposes according to the present invention are done becomes to modify, and all should be encompassed within protection scope of the present invention.
Claims (8)
1. the Chinese medicine composition that antifatigue effect is arranged that contains the Herba Dendrobii tool adopts Chinese crude drug, and combination is characterized in that the Chinese crude drug of employing comprises Herba Dendrobii, Radix Ginseng, Radix Et Caulis Acanthopanacis Senticosi by ratio of weight and the number of copies; Zu He Herba Dendrobii, Radix Ginseng, Radix Et Caulis Acanthopanacis Senticosi constitute Chinese medicine composition by ratio of weight and the number of copies.
2. the Chinese medicine composition that antifatigue effect is arranged that contains the Herba Dendrobii tool according to claim 1, it is characterized in that, Zu He Herba Dendrobii, Radix Ginseng, Radix Et Caulis Acanthopanacis Senticosi parts by weight separately are by ratio of weight and the number of copies: 1 ~ 5 part of Herba Dendrobii, 2 ~ 6 parts of Radix Ginsengs, 1 ~ 3 part of Radix Et Caulis Acanthopanacis Senticosi.
3. the Chinese medicine composition that antifatigue effect is arranged that contains the Herba Dendrobii tool according to claim 1, it is characterized in that, Zu He Herba Dendrobii, Radix Ginseng, Radix Et Caulis Acanthopanacis Senticosi parts by weight separately are by ratio of weight and the number of copies: 3 parts of Herba Dendrobii, 4 parts of Radix Ginsengs, 2 parts of Radix Et Caulis Acanthopanacis Senticosis.
4. the preparation method that contains the Chinese medicine composition that antifatigue effect is arranged of Herba Dendrobii tool, select Chinese crude drug by the ratio of weight and number of determining, the Chinese crude drug of selecting is processed, obtain Chinese medicine composition, it is characterized in that selecting Chinese crude drug by ratio of weight and the number of copies is Herba Dendrobii, Radix Ginseng, Radix Et Caulis Acanthopanacis Senticosi; The Chinese crude drug of selecting is carried out method for processing is, the Chinese crude drug that chooses is mixed, add etoh solvent and make mixed liquor, adopt the method for reflux, extract,, pharmaceutical compositions to stripping in the mixed liquor extracts, and obtains the extracting solution that medical value is arranged in the mixed liquor, the elimination medicinal residues, extracting solution is handled, obtained Chinese medicine composition; Obtaining Chinese medicine composition is the Chinese medicine composition that contains Herba Dendrobii, Radix Ginseng and Radix Et Caulis Acanthopanacis Senticosi pharmaceutical compositions; Step comprises:
Step 1 is selected raw material of Chinese medicine: take by weighing Herba Dendrobii, Radix Ginseng, Radix Et Caulis Acanthopanacis Senticosi in proportion;
Step 2 is produced mixed liquor: after will taking by weighing Herba Dendrobii, Radix Ginseng, Fructus Lycii and Fructus Momordicae mixing, add adequate amount of ethanol and make mixed liquor, the mixed liquor Chinese medicine is fully stirred the companion, improve the liquor strength of mixed liquor Chinese medicine stripping;
Step 3, reflux, extract: adopt the method for reflux, extract,, the mixed liquor that step 2 is produced carries out reflux, extract,, mixed-liquor return extracted 2 times, each 2 ~ 3 hours, the elimination medicinal residues;
Step 4, extracting solution is handled: the extracting solution that 2 times are extracted in the combining step 3, the extracting solution that is combined carries out concentrating under reduced pressure, and it is spray-dried, obtain dried powder, dried powder is sieved, obtain containing the Chinese medicine composition of Herba Dendrobii, Radix Ginseng and Radix Et Caulis Acanthopanacis Senticosi pharmaceutical compositions.
5. the preparation method that contains the Chinese medicine composition that antifatigue effect is arranged of Herba Dendrobii tool according to claim 4 is characterized in that, the concentration of the adequate amount of ethanol that adds in the step 2 is 60%.
6. Chinese medicine preparation of being made by the Chinese medicine composition with antifatigue effect that contains Herba Dendrobii, comprise pharmaceutical adjuvant, it is characterized in that, employing contains the Chinese medicine composition with antifatigue effect of Herba Dendrobii, according to the preparation needs, in the Chinese medicine composition of the antifatigue effect that contains Herba Dendrobii, be equipped with a certain amount of pharmaceutical adjuvant in the ratio of determining, make the Chinese medicine preparation with antifatigue effect.
7. a kind of Chinese medicine preparation of being made by the Chinese medicine composition with antifatigue effect that contains Herba Dendrobii according to claim 6, it is characterized in that the Chinese medicine preparation made from antifatigue effect is slow releasing agent, granule, capsule, drop pill, tablet, the oral liquid in the medical common formulations.
8. a kind of Chinese medicine preparation of being made by the Chinese medicine composition with antifatigue effect that contains Herba Dendrobii according to claim 6, it is characterized in that the Chinese medicine preparation made from antifatigue effect is a kind of in the slow releasing agent, granule, capsule, drop pill, tablet, oral liquid in the medical common formulations.
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Application publication date: 20131009 |