CN107929413A - A kind of antifatigue Chinese medicine composition and its application and preparation method - Google Patents
A kind of antifatigue Chinese medicine composition and its application and preparation method Download PDFInfo
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Abstract
The present invention relates to a kind of antifatigue Chinese medicine composition and its application and preparation method.The Chinese medicine composition is made of the bulk pharmaceutical chemicals of following parts by weight：12 18 parts of Herba Epimedii, 10 15 parts of Rhizoma Atractylodis Macrocephalae, 10 15 parts of Poria cocos, 10 15 parts of radix pseudostellariae, 9 11 parts of Radix Salviae Miltiorrhizae, 48 parts of radix bupleuri, 48 parts of Schisandra chinensis, 48 parts of dried orange peel.The preparation method is according to various flavor and contained different chemical composition, and it is canned to synthesize concentration mixing after classification extraction again.The Chinese medicine composition warming and invigorating kidney Yang of the present invention, strengthening the spleen and stomach, soothing the liver moistening lung, the sensible qi and blood of mental-tranquilization, adjusts the dual power of negative and positive principles, and is effective against and fatigue-relieving, and flavour of a drug composition is few, of low cost easy to prepare.
Description
Technical field
The present invention relates to the field of Chinese medicines, specifically, is related to a kind of antifatigue Chinese medicine composition and its application and preparation
Method.
Background technology
Fatigue be by caused by multifactor impact in body many physiological acoustic signals combined reaction.It is tired to be divided into corporality
Labor and psychological fatigue, body tiredness are mainly shown as the decline of locomitivity, psychological fatigue be mainly shown as behavior with
The passive change of will.As social work and rhythm of life are getting faster, from work, family, house, medical treatment, interpersonal pass
The pressure of system etc. makes one to be chronically at tense situation, is easy to trigger body tiredness and psychological fatigue, cause it is sleepy, dizzy,
The simultaneous phenomenons such as forgetful, sleep quality decline, seriously affect quality of life, cannot alleviate may trigger disease for a long time.It is tired
It is close that the generation of labor and energy substance consumption, metabolite accumulation, homeostasis sexual maladjustment, free radical such as influence at the factor relation
Cut.
The traditional Chinese medical science thinks that the etiology and pathogenesis of fatigue is：" the spleen being the foundation of acquired constitution, source of generating QI and blood, main muscle, four limbs are main
Transporting and transforming nutrients from foodstuff is precise and tiny and water is wet, eating and drinking without temperance or impairing the spleen and stomach of worrying beyond measure, the dysfunction of the spleen in transport, then the biochemical weary source of qi and blood, and clear sun is not
Rise, failure in sending down turbid yin, limb muscle, which loses, supports therefore see powerless, dizziness headache of having aches in the limbs, loss of appetite, abdominal distension diarrhea etc..Fatigue relates to
And the vital organs of the human body, mainly based on spleen, liver, kidney.Can be recuperated under medical treatment by Chinese medical discrimination prescription, with reach prevention, treatment, control
Purpose.
Prescription antifatigue in terms of the traditional Chinese medical science is more at present, such as：Patent document CN103275855A, publication date
2013.09.04, a kind of Anti-fatigue health care wine and preparation method thereof is disclosed, the Anti-fatigue health care wine is by following parts by weight
Raw material be made：20-30 grams of Radix Salviae Miltiorrhizae, 15-25 grams of lily, 15-25 grams of radix rehmanniae recen, 15-20 grams of Herba Epimedii, 15-20 grams of Semen Lablab Album,
8-12 grams of lotus seeds, 8-12 grams of polygala, 8-12 grams of Schisandra chinensis, 6-10 grams of the fruit of Chinese wolfberry, 6-10 grams of jujube, 4-7 grams of radix glycyrrhizae, Angelica sinensis 4-7
Gram, 4-7 grams of Rhizoma Atractylodis Macrocephalae, 45 degree of 3000-4000 grams of white wine.The antifatigue positive effect of the health liquor, preparation method is simple, cost is low.
Patent document CN105194211A, publication date 2015.12.30, disclose a kind of Chinese medicine for alleviating women chronic fatigue syndrome
Oral liquid and preparation method, the traditional Chinese medicine oral liquid are made of following raw material：17-23 parts of radix pseudostellariae, Chinese yam 27-33
Part, 27-33 parts of mother-of-pearl, 27-33 parts of astragalus root, 12-18 parts of dogwood fruit, 17-23 parts of Poria cocos, 12-18 parts of Angelica sinensis, the fruit of glossy privet
12-18 parts, 12-18 parts of Rhizoma Atractylodis Macrocephalae, 12-18 parts of prepared rhizome of rehmannia, 22-28 parts of Radix Salviae Miltiorrhizae, 17-23 parts of Radix Paeoniae Alba, 9-15 parts of Schisandra chinensis, honey-fried licorice root
5-11 parts.The traditional Chinese medicine oral liquid has effects that nourishing liver and kidney, YIN and YANG balance regulating, conditioning viscera, tune fill blood.Patent document
CN1569107A, publication date 2005.01.26, disclose a kind of medicine for treating chronic fatigue syndrome and preparation method thereof, institute
The medicine stated is made of the raw material that following weight matches：Gynostemma pentaphylla 300-350, radix astragali 130-150, corydalis tuber 60-70, Angelica sinensis
50-80, ginseng 50-80, Rhizoma Atractylodis Macrocephalae 60-70, Poria cocos 60-70, arillus longan 60-70, spina date seed 60-70, grass-leaved sweetflag 60-70, polygala
60-70, Schisandra chinensis 300-350, ophiopogon 60-70, Radix Salviae Miltiorrhizae 60-70, Ligusticum wallichii 60-70, banksia rose 60-70.Production method be by ginseng,
Angelica sinensis, grass-leaved sweetflag are ground into thin medicinal powder, remaining medicine are closed altogether water extraction liquid is made, then concentrated into thick paste, add above-mentioned 3
The thin medicinal powder of taste medicine, is uniformly mixed, through drying, crushing, sterilizing, any type medicament such as capsule, pill, tablet, powder is made
Learn described formulation.The medicine has the effect of tonifying heart and spleen, tranquilize the mind and promote the intelligence.
But shortage flavour of a drug number is less at present, compatibility is precise and appropriate, significant anti-fatigue Chinese medicinal composition curative for effect.
The applicant patent CN102772732A before this, publication date 2012.11.14, disclose a kind of slow for treating
The pharmaceutical composition and its application, the pharmaceutical composition of property hepatopathy are made of the bulk pharmaceutical chemicals of following parts by weight：Kiwi-fruit juice
20-60 parts, 10-30 parts of Radix Salviae Miltiorrhizae, 5-15 parts of Rhizoma Atractylodis Macrocephalae, 4-12 parts of Herba Epimedii, 4-12 parts of Poria cocos, 2-6 parts of radix bupleuri, Schisandra chinensis 5-15
Part, bandit 1.5-4.5 parts white, 2.5-7.5 parts of dried orange peel, 5-15 parts of radix pseudostellariae.Detoxify basic the patent proposes empty, yin-nourishing is managed
Therapy, sets about from spleen kidney, melting down thermal detoxification, vital energy regualting and blood circulation-promoting, strengthening the spleen and stomach, and the method such as nourishing the liver and kidney is stringent in a stove, compound compatibility
Traditional Chinese medical science traditional theory is followed, referring also to distributing rationally for proved recipe classical prescription, the rigorous novelty of prescription, Clinical and experimental study result table
The bright pharmaceutical composition has chronic liver disease exact therapeutic effect, and cost is relatively low, has no toxic side effect, short treating period, markedly fast, controls
More rate is high, more after do not recur substantially.Now this seminar finds have after the Chinese prescription of the patent is modified at antifatigue aspect
Remarkable result.
The content of the invention
The purpose of the present invention is for deficiency of the prior art, there is provided a kind of antifatigue Chinese medicine composition.
Another purpose of the present invention is to provide the purposes of the Chinese medicine composition.
Another purpose of the present invention is to provide the preparation method of the Chinese medicine composition.
To realize above-mentioned first purpose, the present invention adopts the technical scheme that：
A kind of antifatigue Chinese medicine composition, the Chinese medicine composition are made of the bulk pharmaceutical chemicals of following parts by weight：Excessive sheep
12-18 parts of the leaves of pulse plants, 10-15 parts of Rhizoma Atractylodis Macrocephalae, 10-15 parts of Poria cocos, 10-15 parts of radix pseudostellariae, 9-11 parts of Radix Salviae Miltiorrhizae, 4-8 parts of radix bupleuri, Schisandra chinensis 4-
8 parts, 4-8 parts of dried orange peel.
Preferably, the Chinese medicine composition is made of the bulk pharmaceutical chemicals of following parts by weight：14-16 parts of Herba Epimedii, Rhizoma Atractylodis Macrocephalae 11-
14 parts, 11-14 parts of Poria cocos, 11-14 parts of radix pseudostellariae, 9-11 parts of Radix Salviae Miltiorrhizae, 5-7 parts of radix bupleuri, 5-7 parts of Schisandra chinensis, 5-7 parts of dried orange peel.
It is highly preferred that the Chinese medicine composition is made of the bulk pharmaceutical chemicals of following parts by weight：15 parts of Herba Epimedii, Rhizoma Atractylodis Macrocephalae 12
Part, 12 parts of Poria cocos, 12 parts of radix pseudostellariae, 10 parts of Radix Salviae Miltiorrhizae, 6 parts of radix bupleuri, 6 parts of Schisandra chinensis, 6 parts of dried orange peel.
As the specific embodiment of the present invention, the formulation of the Chinese medicine composition is mixture, granule, capsule
Or tablet, but not limited to this.
Preferably, the formulation of the Chinese medicine composition is mixture.
To realize above-mentioned second purpose, the present invention adopts the technical scheme that：
Application of the Chinese medicine composition in antifatigue medicine is prepared.
The fatigue is body tiredness.
To realize above-mentioned 3rd purpose, the present invention adopts the technical scheme that：
The preparation method of the Chinese medicine composition, comprises the following steps：
1) Schisandra chinensis, radix bupleuri, dried orange peel, Rhizoma Atractylodis Macrocephalae are put into boiler, add the water of 2-4 times of weight to be distilled, take distillation
Volatile oil solution, another device are sealed spare；The dregs of a decoction after by distillation add water, decoct 0.5-2 it is small when, stand 5-15 it is small when after
Juice is filtered to take, receipts fill to be concentrated；
2) Radix Salviae Miltiorrhizae, radix pseudostellariae, Herba Epimedii, Poria cocos are put into decoction pot, add boiling 1-3 times, keep boiling 0.5-1.5 small
Shi Hou, treats natural cooling after leaching juice, merges each secondary decocting liquid, stand 3-8 it is small when after after leaching juice, receipts fill system to be mixed
Make；
3) volatile matter distillation oil solution and filtered fluid that step 1) obtains are mixed with the filtered fluid that step 2) obtains, taken low
Warm vacuum concentration method, it is filling to be carried out after the liquid of 1.0-1.2 to be concentrated into proportion.
Preferably, comprise the following steps：
1) Schisandra chinensis, radix bupleuri, dried orange peel, Rhizoma Atractylodis Macrocephalae are put into boiler, add the water of 3 times of weight to be distilled, take distillation to wave
Hair oil solution, another device are sealed spare；The dregs of a decoction after by distillation add water, decoct 1 it is small when, stand 10 it is small when after filter to take
Juice, receipts fill to be concentrated；
2) Radix Salviae Miltiorrhizae, radix pseudostellariae, Herba Epimedii, Poria cocos are put into decoction pot, add boiling 2 times, when keeping boiling 1 small after, treat
Natural cooling merges decocting liquid twice after leaching juice, stand 6 it is small when after after leaching juice, receipts fill making to be mixed；
3) volatile matter distillation oil solution and filtered fluid that step 1) obtains are mixed with the filtered fluid that step 2) obtains, taken low
Warm vacuum concentration method, it is filling to be carried out after 1.1 liquid to be concentrated into proportion.
The invention has the advantages that：
1st, Chinese medicine composition of the invention, Herba Epimedii kidney-replenishing in side, strengthening the bones and muscles, Gu the congenital foundation, is monarch drug in a prescription；Rhizoma Atractylodis Macrocephalae is good for
Spleen QI invigorating, eliminate dampness and have diuretic effect, radix pseudostellariae strengthening the spleen and replenishing qi is promoting production of body fluid and nourishing the lung, Poria cocos strengthening the spleen and stomach, eliminating dampness and diuresis, and three is ministerial drug altogether, grows
The foundation of acquired constitution, supports lung qi, enriching spleen-QI, clearing damp gas；Gas is held back in radix bupleuri soothing liver-qi stagnation air-dispersing, Schisandra chinensis mental-tranquilization, and dried orange peel assists reason
The gas of middle Jiao, three's reconciliation mechanism of qi, the gas of perforation all over the body up and down is to help；One medicine of Radix Salviae Miltiorrhizae supports four things, and promoting blood circulation, is dredged through dredging collateral,
Motion in quiescence, promotes promoting the circulation of qi to make medicine；All medicines share, balanced human's the five internal organs, warming and invigorating kidney Yang, strengthening the spleen and stomach, soothing the liver moistening lung, nourishing heart
To calm the nerves, sensible qi and blood, adjusts the dual power of negative and positive principles, admittedly it is effective against and fatigue-relieving.
2nd, Chinese medicine composition of the invention focuses on each medicinal material nature and flavor of reconciliation, and the cool mutual aid of temperature, avoided being damaged with cold and cool medicinal material
Hinder the effect of kidney tonifying, all medicine Yin Yang balancings, are obviously improved antifatigue effect.
3rd, traditional Chinese medicinal composition raw materials of the invention composition is few, and easy to prepare, cost is low.
4th, the preparation method of Chinese medicine composition of the present invention is divided according to bulk pharmaceutical chemicals various flavor and contained different chemical composition
Concentration is synthesized again after class extraction and mixes canned, extracting method science, can farthest extract and retain the active ingredient of medicine.
Embodiment
Elaborate below to embodiment provided by the invention.
The preparation (one) of the Chinese medicine composition mixture of the present invention of embodiment 1
Parts by weight form：15 parts of Herba Epimedii, 12 parts of Rhizoma Atractylodis Macrocephalae, 12 parts of Poria cocos, 12 parts of radix pseudostellariae, 10 parts of Radix Salviae Miltiorrhizae, 6 parts of radix bupleuri,
6 parts of Schisandra chinensis, 6 parts of dried orange peel.
1) Schisandra chinensis, radix bupleuri, dried orange peel, Rhizoma Atractylodis Macrocephalae are put into boiler, add the water of 3 times of weight to be distilled, take distillation to wave
Hair oil solution, another device are sealed spare；The dregs of a decoction after by distillation add water, decoct 1 it is small when, stand 10 it is small when after filter to take
Juice, receipts fill to be concentrated；
2) Radix Salviae Miltiorrhizae, radix pseudostellariae, Herba Epimedii, Poria cocos are put into decoction pot, add boiling 2 times, when keeping boiling 1 small after, treat
Natural cooling merges decocting liquid twice after leaching juice, stand 6 it is small when after after leaching juice, receipts fill making to be mixed；
3) volatile matter distillation oil solution and filtered fluid that step 1) obtains are mixed with the filtered fluid that step 2) obtains, taken low
Warm vacuum concentration method, it is filling to be carried out after 1.1 liquid to be concentrated into proportion.
The preparation (two) of the Chinese medicine composition mixture of the present invention of embodiment 2
Parts by weight form：12 parts of Herba Epimedii, 15 parts of Rhizoma Atractylodis Macrocephalae, 10 parts of Poria cocos, 15 parts of radix pseudostellariae, 9 parts of Radix Salviae Miltiorrhizae, 8 parts of radix bupleuri, five
4 parts of taste, 8 parts of dried orange peel.
1) Schisandra chinensis, radix bupleuri, dried orange peel, Rhizoma Atractylodis Macrocephalae are put into boiler, add the water of 3 times of weight to be distilled, take distillation to wave
Hair oil solution, another device are sealed spare；The dregs of a decoction after by distillation add water, decoct 1 it is small when, stand 10 it is small when after filter to take
Juice, receipts fill to be concentrated；
2) Radix Salviae Miltiorrhizae, radix pseudostellariae, Herba Epimedii, Poria cocos are put into decoction pot, add boiling 2 times, when keeping boiling 1 small after, treat
Natural cooling merges decocting liquid twice after leaching juice, stand 6 it is small when after after leaching juice, receipts fill making to be mixed；
3) volatile matter distillation oil solution and filtered fluid that step 1) obtains are mixed with the filtered fluid that step 2) obtains, taken low
Warm vacuum concentration method, it is filling to be carried out after 1.1 liquid to be concentrated into proportion.
The preparation (three) of the Chinese medicine composition mixture of the present invention of embodiment 3
Parts by weight form：18 parts of Herba Epimedii, 10 parts of Rhizoma Atractylodis Macrocephalae, 15 parts of Poria cocos, 10 parts of radix pseudostellariae, 11 parts of Radix Salviae Miltiorrhizae, 4 parts of radix bupleuri,
8 parts of Schisandra chinensis, 4 parts of dried orange peel.
1) Schisandra chinensis, radix bupleuri, dried orange peel, Rhizoma Atractylodis Macrocephalae are put into boiler, add the water of 3 times of weight to be distilled, take distillation to wave
Hair oil solution, another device are sealed spare；The dregs of a decoction after by distillation add water, decoct 1 it is small when, stand 10 it is small when after filter to take
Juice, receipts fill to be concentrated；
2) Radix Salviae Miltiorrhizae, radix pseudostellariae, Herba Epimedii, Poria cocos are put into decoction pot, add boiling 2 times, when keeping boiling 1 small after, treat
Natural cooling merges decocting liquid twice after leaching juice, stand 6 it is small when after after leaching juice, receipts fill making to be mixed；
3) volatile matter distillation oil solution and filtered fluid that step 1) obtains are mixed with the filtered fluid that step 2) obtains, taken low
Warm vacuum concentration method, it is filling to be carried out after 1.1 liquid to be concentrated into proportion.
The preparation (four) of the Chinese medicine composition mixture of the present invention of embodiment 4
Parts by weight form：12 parts of Herba Epimedii, 10 parts of Rhizoma Atractylodis Macrocephalae, 15 parts of Poria cocos, 15 parts of radix pseudostellariae, 9 parts of Radix Salviae Miltiorrhizae, 4 parts of radix bupleuri, five
8 parts of taste, 8 parts of dried orange peel.
1) Schisandra chinensis, radix bupleuri, dried orange peel, Rhizoma Atractylodis Macrocephalae are put into boiler, add the water of 2 times of weight to be distilled, take distillation to wave
Hair oil solution, another device are sealed spare；The dregs of a decoction after by distillation add water, decoct 2 it is small when, stand 5 it is small when after filter to take juice,
Receipts fill to be concentrated；
2) Radix Salviae Miltiorrhizae, radix pseudostellariae, Herba Epimedii, Poria cocos are put into decoction pot, add boiling 3 times, when keeping boiling 0.5 small after,
Natural cooling is treated after leaching juice, merges each secondary decocting liquid, stand 8 it is small when after after leaching juice, receipts fill making to be mixed；
3) volatile matter distillation oil solution and filtered fluid that step 1) obtains are mixed with the filtered fluid that step 2) obtains, taken low
Warm vacuum concentration method, it is filling to be carried out after 1.0 liquid to be concentrated into proportion.
The preparation (five) of the Chinese medicine composition mixture of the present invention of embodiment 5
Parts by weight form：18 parts of Herba Epimedii, 15 parts of Rhizoma Atractylodis Macrocephalae, 10 parts of Poria cocos, 10 parts of radix pseudostellariae, 11 parts of Radix Salviae Miltiorrhizae, 8 parts of radix bupleuri,
4 parts of Schisandra chinensis, 4 parts of dried orange peel.
1) Schisandra chinensis, radix bupleuri, dried orange peel, Rhizoma Atractylodis Macrocephalae are put into boiler, add the water of 4 times of weight to be distilled, take distillation to wave
Hair oil solution, another device are sealed spare；The dregs of a decoction after by distillation add water, decoct 0.5 it is small when, stand 15 it is small when after filter to take
Juice, receipts fill to be concentrated；
2) Radix Salviae Miltiorrhizae, radix pseudostellariae, Herba Epimedii, Poria cocos are put into decoction pot, add boiling 1 time, when keeping boiling 1.5 small after,
Natural cooling is treated after leaching juice, stand 3 it is small when after after leaching juice, receipts fill making to be mixed；
3) volatile matter distillation oil solution and filtered fluid that step 1) obtains are mixed with the filtered fluid that step 2) obtains, taken low
Warm vacuum concentration method, it is filling to be carried out after 1.2 liquid to be concentrated into proportion.
The preparation (six) of the Chinese medicine composition mixture of the present invention of embodiment 6
Parts by weight form：12 parts of Herba Epimedii, 10 parts of Rhizoma Atractylodis Macrocephalae, 10 parts of Poria cocos, 15 parts of radix pseudostellariae, 11 parts of Radix Salviae Miltiorrhizae, 8 parts of radix bupleuri,
4 parts of Schisandra chinensis, 4 parts of dried orange peel.
1) Schisandra chinensis, radix bupleuri, dried orange peel, Rhizoma Atractylodis Macrocephalae are put into boiler, add the water of 2 times of weight to be distilled, take distillation to wave
Hair oil solution, another device are sealed spare；The dregs of a decoction after by distillation add water, decoct 1 it is small when, stand 10 it is small when after filter to take
Juice, receipts fill to be concentrated；
2) Radix Salviae Miltiorrhizae, radix pseudostellariae, Herba Epimedii, Poria cocos are put into decoction pot, add boiling 3 times, when keeping boiling 1 small after, treat
Natural cooling merges each secondary decocting liquid after leaching juice, stand 6 it is small when after after leaching juice, receipts fill making to be mixed；
3) volatile matter distillation oil solution and filtered fluid that step 1) obtains are mixed with the filtered fluid that step 2) obtains, taken low
Warm vacuum concentration method, it is filling to be carried out after 1.1 liquid to be concentrated into proportion.
The preparation (seven) of the Chinese medicine composition mixture of the present invention of embodiment 7
Parts by weight form：14 parts of Herba Epimedii, 14 parts of Rhizoma Atractylodis Macrocephalae, 11 parts of Poria cocos, 14 parts of radix pseudostellariae, 9 parts of Radix Salviae Miltiorrhizae, 7 parts of radix bupleuri, five
5 parts of taste, 7 parts of dried orange peel.
1) Schisandra chinensis, radix bupleuri, dried orange peel, Rhizoma Atractylodis Macrocephalae are put into boiler, add the water of 3 times of weight to be distilled, take distillation to wave
Hair oil solution, another device are sealed spare；The dregs of a decoction after by distillation add water, decoct 1 it is small when, stand 10 it is small when after filter to take
Juice, receipts fill to be concentrated；
2) Radix Salviae Miltiorrhizae, radix pseudostellariae, Herba Epimedii, Poria cocos are put into decoction pot, add boiling 2 times, when keeping boiling 1 small after, treat
Natural cooling merges decocting liquid twice after leaching juice, stand 6 it is small when after after leaching juice, receipts fill making to be mixed；
3) volatile matter distillation oil solution and filtered fluid that step 1) obtains are mixed with the filtered fluid that step 2) obtains, taken low
Warm vacuum concentration method, it is filling to be carried out after 1.1 liquid to be concentrated into proportion.
The preparation (eight) of the Chinese medicine composition mixture of the present invention of embodiment 8
Parts by weight form：16 parts of Herba Epimedii, 11 parts of Rhizoma Atractylodis Macrocephalae, 14 parts of Poria cocos, 11 parts of radix pseudostellariae, 11 parts of Radix Salviae Miltiorrhizae, 5 parts of radix bupleuri,
7 parts of Schisandra chinensis, 5 parts of dried orange peel.
1) Schisandra chinensis, radix bupleuri, dried orange peel, Rhizoma Atractylodis Macrocephalae are put into boiler, add the water of 3 times of weight to be distilled, take distillation to wave
Hair oil solution, another device are sealed spare；The dregs of a decoction after by distillation add water, decoct 1 it is small when, stand 10 it is small when after filter to take
Juice, receipts fill to be concentrated；
2) Radix Salviae Miltiorrhizae, radix pseudostellariae, Herba Epimedii, Poria cocos are put into decoction pot, add boiling 2 times, when keeping boiling 1 small after, treat
Natural cooling merges decocting liquid twice after leaching juice, stand 6 it is small when after after leaching juice, receipts fill making to be mixed；
3) volatile matter distillation oil solution and filtered fluid that step 1) obtains are mixed with the filtered fluid that step 2) obtains, taken low
Warm vacuum concentration method, it is filling to be carried out after 1.1 liquid to be concentrated into proportion.
The preparation (nine) of the Chinese medicine composition mixture of the present invention of embodiment 9
Parts by weight form：14 parts of Herba Epimedii, 14 parts of Rhizoma Atractylodis Macrocephalae, 11 parts of Poria cocos, 12 parts of radix pseudostellariae, 10 parts of Radix Salviae Miltiorrhizae, 6 parts of radix bupleuri,
6 parts of Schisandra chinensis, 6 parts of dried orange peel.
1) Schisandra chinensis, radix bupleuri, dried orange peel, Rhizoma Atractylodis Macrocephalae are put into boiler, add the water of 3 times of weight to be distilled, take distillation to wave
Hair oil solution, another device are sealed spare；The dregs of a decoction after by distillation add water, decoct 1 it is small when, stand 10 it is small when after filter to take
Juice, receipts fill to be concentrated；
2) Radix Salviae Miltiorrhizae, radix pseudostellariae, Herba Epimedii, Poria cocos are put into decoction pot, add boiling 2 times, when keeping boiling 1 small after, treat
Natural cooling merges decocting liquid twice after leaching juice, stand 6 it is small when after after leaching juice, receipts fill making to be mixed；
3) volatile matter distillation oil solution and filtered fluid that step 1) obtains are mixed with the filtered fluid that step 2) obtains, taken low
Warm vacuum concentration method, it is filling to be carried out after 1.1 liquid to be concentrated into proportion.
The preparation (ten) of the Chinese medicine composition mixture of the present invention of embodiment 10
Parts by weight form：14 parts of Herba Epimedii, 14 parts of Rhizoma Atractylodis Macrocephalae, 11 parts of Poria cocos, 12 parts of radix pseudostellariae, 10 parts of Radix Salviae Miltiorrhizae, 6 parts of radix bupleuri,
6 parts of Schisandra chinensis, 6 parts of dried orange peel.
1) Schisandra chinensis, radix bupleuri, dried orange peel, Rhizoma Atractylodis Macrocephalae are put into boiler, add the water of 4 times of weight to be distilled, take distillation to wave
Hair oil solution, another device are sealed spare；The dregs of a decoction after by distillation add water, decoct 0.5 it is small when, stand 15 it is small when after filter to take
Juice, receipts fill to be concentrated；
2) Radix Salviae Miltiorrhizae, radix pseudostellariae, Herba Epimedii, Poria cocos are put into decoction pot, add boiling 1 time, when keeping boiling 1.5 small after,
Natural cooling is treated after leaching juice, stand 3 it is small when after after leaching juice, receipts fill making to be mixed；
3) volatile matter distillation oil solution and filtered fluid that step 1) obtains are mixed with the filtered fluid that step 2) obtains, taken low
Warm vacuum concentration method, it is filling to be carried out after 1.2 liquid to be concentrated into proportion.
The preparation of 11 Chinese medicinal composition granules of the present invention of embodiment
Concentrated medicament is prepared according to any methods of embodiment 1-10, adds dextrin and appropriate Steviosin, mixes
It is even, fine powder is dry, pulverize into, adds appropriate amount of ethanol to pelletize, it is dry, to obtain the final product.
The preparation of the Chinese medicinal composition capsules agent of the present invention of embodiment 12
Concentrated medicament is prepared according to any methods of embodiment 1-10, takes supernatant to add dextrin and Steviosin
In right amount, mix, dry, pulverize into fine powder, add appropriate amount of ethanol to pelletize, dry, pulverize, filling is encapsulated.
The preparation of 13 Chinese medicine composition tablet of the present invention of embodiment
Concentrated medicament is prepared according to any methods of embodiment 1-10, tablet customary adjuvant is added, after dry
Crush granulation, by No. two sieve whole grains, tabletting, sugar coating, to obtain the final product.
The antifatigue experiment of 14 Chinese medicine composition of the present invention of embodiment
1st, experimental animal
ICR mouse 120, male, weight 18-22g, is provided by Shanghai Slac Experimental Animal Co., Ltd., is permitted
Can the number of card SCXK (Shanghai) 2012-0002.5 groups, every group 24 are randomly divided into by weight.During the experiment, the environment of animal feeding are protected
Hold in 25 ± 2 DEG C of room temperature, relative humidity 50%-70%, mouse freely absorbs food and water.
2nd, experimental drug
Chinese medicine composition prepared by the method according to embodiment 1.
Contrast Chinese medicine one：Parts by weight form：20 parts of kiwi-fruit juice, 10 parts of Radix Salviae Miltiorrhizae, 5 parts of Rhizoma Atractylodis Macrocephalae, 4 parts of Herba Epimedii, Poria cocos 4
Part, 2 parts of radix bupleuri, 5 parts of Schisandra chinensis, 1.5 parts of white bandit, 2.5 parts of dried orange peel, 5 parts of radix pseudostellariae.Preparation method is：(1) by Schisandra chinensis, bavin
Recklessly, Bai Kou, dried orange peel, the Rhizoma Atractylodis Macrocephalae five tastes are put into boiler, add the water of three times weight to be distilled, and take volatile matter distillation oil solution, separately
Device is sealed spare；The dregs of a decoction after distillation are added into water, are decocted one hour, juice is filtered to take after standing ten hours, receipts fill to be concentrated；
(2) Radix Salviae Miltiorrhizae, Tong Can, Herba Epimedii, four taste of Poria cocos are put into decoction pot, add boiling twice, after keeping boiling one hour, treat that nature is cold
But after leaching juice, merge decocting liquid twice, making to be mixed is filled after leaching juice, receipts after standing six hours；(3) by step (1)
(2) filtered fluid mixing take low-temperature reduced-pressure concentration method, be concentrated into proportion be 1.1 liquid after add white granulated sugar boil it is rear molten
The weight ratio 30 of solution, concentrate and white granulated sugar:10, filtering, filtrate and the volatile matter distillation oil solution of kiwi-fruit juice and step (1) mix
Close, the weight ratio 20 of filtrate and kiwi-fruit juice:10, carried out after stirring filling.
Contrast Chinese medicine two：Parts by weight form：15 parts of Herba Epimedii, 12 parts of Rhizoma Atractylodis Macrocephalae, 12 parts of Poria cocos, 12 parts of radix pseudostellariae, Radix Salviae Miltiorrhizae
20 parts, 6 parts of radix bupleuri, 6 parts of Schisandra chinensis, 6 parts of dried orange peel.Preparation method is：1) Schisandra chinensis, radix bupleuri, dried orange peel, Rhizoma Atractylodis Macrocephalae are put into boiler
It is interior, add the water of 3 times of weight to be distilled, take volatile matter distillation oil solution, another device is sealed spare；The dregs of a decoction after by distillation add
Water, decoct 1 it is small when, stand 10 it is small when after filter to take juice, receipts fill to be concentrated；2) Radix Salviae Miltiorrhizae, radix pseudostellariae, Herba Epimedii, Poria cocos are put into
In decoction pot, add boiling 2 times, when keeping boiling 1 small after, treat that natural cooling after leaching juice, merges decocting liquid twice, it is small to stand 6
When after after leaching juice, receipts fill making to be mixed；3) the volatile matter distillation oil solution and filtered fluid obtained step 1) and step 2)
Obtained filtered fluid mixing, takes low-temperature reduced-pressure concentration method, and it is filling to be carried out after 1.1 liquid to be concentrated into proportion.
Contrast Chinese medicine three：Parts by weight form：15 parts of Herba Epimedii, 12 parts of Rhizoma Atractylodis Macrocephalae, 12 parts of Gorgon fruit, 12 parts of radix pseudostellariae, Radix Salviae Miltiorrhizae
20 parts, 6 parts of radix bupleuri, 6 parts of Schisandra chinensis, 6 parts of dried orange peel.Preparation method is：1) Schisandra chinensis, radix bupleuri, dried orange peel, Rhizoma Atractylodis Macrocephalae are put into boiler
It is interior, add the water of 3 times of weight to be distilled, take volatile matter distillation oil solution, another device is sealed spare；The dregs of a decoction after by distillation add
Water, decoct 1 it is small when, stand 10 it is small when after filter to take juice, receipts fill to be concentrated；2) Radix Salviae Miltiorrhizae, radix pseudostellariae, Herba Epimedii, Gorgon fruit are put into
In decoction pot, add boiling 2 times, when keeping boiling 1 small after, treat that natural cooling after leaching juice, merges decocting liquid twice, it is small to stand 6
When after after leaching juice, receipts fill making to be mixed；3) the volatile matter distillation oil solution and filtered fluid obtained step 1) and step 2)
Obtained filtered fluid mixing, takes low-temperature reduced-pressure concentration method, and it is filling to be carried out after 1.1 liquid to be concentrated into proportion.
3rd, experimental method
3.1 packets and administration
Mouse adaptability is fed 3 days, is randomly divided into 5 groups by weight afterwards, is respectively blank control group, Chinese medicine of the present invention
Group, contrast one group of Chinese medicine and, contrast two groups of Chinese medicine and contrast three groups of Chinese medicine.
Chinese medicine group of the present invention：The liquid of the preparation of embodiment 1 is given, by 0.2ml/20g weight gastric infusions, daily administration 1
It is secondary, continuous 30 days.
Contrast one group of Chinese medicine：Contrast Chinese medicine one is given, by 0.2ml/20g weight gastric infusions, is administered once daily, continuously
30 days.
Contrast two groups of Chinese medicine：Contrast Chinese medicine two is given, by 0.2ml/20g weight gastric infusions, is administered once daily, continuously
30 days.
Contrast three groups of Chinese medicine：Contrast Chinese medicine three is given, by 0.2ml/20g weight gastric infusions, is administered once daily, continuously
30 days.
Blank control group：Physiological saline is given, by 0.2ml/20g weight gastric infusions, is administered once daily, continuous 30 days.
3.2 index observing
3.2.1 body weight determination
Weigh in and record respectively before the 1st day of experiment and intragastric administration on mice administration in the 30th day.
3.2.2 walking weight load measures
After last gastric infusion 30 minutes, every group is taken out mouse 8 at random, by 5% weight of mouse tail root load
Sheet lead, be placed in depth of water 30cm, 25 ± 1.0 DEG C of water temperature container in, observe its swimming situation, record mouse from swim till death
The time died.
3.2.3 blood lactase acid measures
After last gastric infusion 30 minutes, every group is taken out mouse 8, conventional method measure blood lactate concentration at random；So
Be placed on depth of water 30cm, the container of 30 ± 1.0 DEG C of water temperature is swum 10 minutes, is taken out, hot-air seasoning, it is quiet after twenty minutes, then survey
Determine blood lactate concentration.
3.2.4 urea measures
After last gastric infusion 30 minutes, every group is taken out mouse 8 at random, and mouse is placed in depth of water 30cm, water temperature 30
± 1.0 DEG C of container is swum 90 minutes, is taken out, and hot-air seasoning, makes peace and quiet, takes mouse blood to be placed in the centrifuge tube for scribbling heparin, from
The heart, takes serum to measure urea concentration.
4th, data processing
Experimental data is usedRepresent, significance test of difference, P are carried out with ANOVA variance analyses<0.05 is considered
Difference has statistical significance.
5th, experimental result
Influence of the 5.1 each group medicines to mouse weight
Weight record the results are shown in Table 1.Data are compared between group, the results showed that, before experiment and test latter two time point,
Between each group mouse weight and there was no significant difference (P>0.05), show that each group medicine does not cause the abnormal change of mouse weight
Change.
Influence of the 1 each group medicine of table to mouse weight
Influence of the 5.2 each group medicines to the mice burden swimming time
Each group mice burden swimming time measurement result is shown in Table 2.The result shows that compared to blank control group, each group mouse
Walking weight load extended, wherein the difference of Chinese medicine group of the present invention and blank control group reaches the pole level of signifiance (P<
0.01), contrast one group of Chinese medicine and the difference of three groups of Chinese medicine of contrast and blank control group reaches the level of signifiance (P<0.05).Compared to
Chinese medicine group of the present invention, the walking weight load of one group of Chinese medicine of contrast, two groups of Chinese medicine of contrast and three groups of Chinese medicine of contrast are considerably shorter than
Chinese medicine group (P of the present invention<0.05).
Influence of the 2 each group medicine of table to the mice burden swimming time
| Group | N (only) | Walking weight load (s) |
| Blank control group | 8 | 282±17 |
| Chinese medicine group of the present invention | 8 | 652±58 |
| Contrast one group of Chinese medicine | 8 | 447±37 |
| Contrast two groups of Chinese medicine | 8 | 363±31 |
| Contrast three groups of Chinese medicine | 8 | 401±50 |
Influence of the 5.3 each group medicines to blood lactate concentration after mouse movement
Each group mouse blood lactate concentration measurement result is shown in Table 3.The result shows that equal compared to blank control group, each group medicine
The blood lactate concentration of 20 minutes after mouse movement can be reduced, wherein Chinese medicine group of the present invention reaches the pole level of signifiance (P<0.01), its
His each group reaches the level of signifiance (P<0.05).Chinese medicine group of the present invention is the most notable to the reducing effect of blood lactate concentration, with contrast
One group of Chinese medicine, two groups of Chinese medicine of contrast and three groups of Chinese medicine of contrast are respectively compared, and difference is respectively provided with statistical significance (P<0.05).
Influence of the 3 each group medicine of table to blood lactate concentration after mouse movement
Influence of the 5.4 each group medicines to serum urea concentration after mouse movement
Each group mice serum urea concentration measurement result is shown in Table 4.The result shows that compared to blank control group, each group medicine
The serum urea concentration after mouse movement can be reduced, wherein Chinese medicine group of the present invention reaches the pole level of signifiance (P<0.01), contrast
One group of Chinese medicine and three groups of Chinese medicine of contrast reach the level of signifiance (P<0.05).Reduction effect of the Chinese medicine group of the present invention to serum urea concentration
Fruit is the most notable, is respectively compared with one group of Chinese medicine of contrast, two groups of Chinese medicine of contrast and three groups of Chinese medicine of contrast, difference is respectively provided with statistics
Meaning (P<0.05).
Influence of the 4 each group medicine of table to serum urea concentration after mouse movement
| Group | N (only) | Serum urea concentration (mmol/L) |
| Blank control group | 8 | 11.02±1.05 |
| Chinese medicine group of the present invention | 8 | 7.08±1.33 |
| Contrast one group of Chinese medicine | 8 | 8.79±1.01 |
| Contrast two groups of Chinese medicine | 8 | 9.35±0.92 |
| Contrast three groups of Chinese medicine | 8 | 8.99±0.88 |
The Chinese medicine composition of the present invention has increase Endurance it can be seen from above-mentioned experimental result, fatigue-relieving
Effect, its compatibility is appropriate, and medicine is imitated specially less, and significant effect is better than other three kinds of Chinese medicine compositions.
The above is only the preferred embodiment of the present invention, it is noted that for the ordinary skill people of the art
Member, on the premise of the method for the present invention is not departed from, can also make some improvement and supplement, these are improved and supplement also should be regarded as
Protection scope of the present invention.
Claims (9)
- A kind of 1. antifatigue Chinese medicine composition, it is characterised in that the Chinese medicine composition by following parts by weight bulk pharmaceutical chemicals It is made：12-18 parts of Herba Epimedii, 10-15 parts of Rhizoma Atractylodis Macrocephalae, 10-15 parts of Poria cocos, 10-15 parts of radix pseudostellariae, 9-11 parts of Radix Salviae Miltiorrhizae, radix bupleuri 4-8 Part, 4-8 parts of Schisandra chinensis, 4-8 parts of dried orange peel.
- 2. Chinese medicine composition according to claim 1, it is characterised in that the Chinese medicine composition is by following parts by weight Bulk pharmaceutical chemicals are made：14-16 parts of Herba Epimedii, 11-14 parts of Rhizoma Atractylodis Macrocephalae, 11-14 parts of Poria cocos, 11-14 parts of radix pseudostellariae, 9-11 parts of Radix Salviae Miltiorrhizae, bavin 5-7 parts of Hu, 5-7 parts of Schisandra chinensis, 5-7 parts of dried orange peel.
- 3. Chinese medicine composition according to claim 2, it is characterised in that the Chinese medicine composition is by following parts by weight Bulk pharmaceutical chemicals are made：15 parts of Herba Epimedii, 12 parts of Rhizoma Atractylodis Macrocephalae, 12 parts of Poria cocos, 12 parts of radix pseudostellariae, 10 parts of Radix Salviae Miltiorrhizae, 6 parts of radix bupleuri, Schisandra chinensis 6 Part, 6 parts of dried orange peel.
- 4. according to any Chinese medicine compositions of claim 1-3, it is characterised in that the formulation of the Chinese medicine composition is Mixture, granule, capsule or tablet.
- 5. Chinese medicine composition according to claim 4, it is characterised in that the formulation of the Chinese medicine composition is mixture.
- 6. application of any Chinese medicine compositions of claim 1-3 in antifatigue medicine is prepared.
- 7. application according to claim 6, it is characterised in that the fatigue is body tiredness.
- 8. the preparation method of any Chinese medicine compositions of claim 1-3, it is characterised in that comprise the following steps：1) Schisandra chinensis, radix bupleuri, dried orange peel, Rhizoma Atractylodis Macrocephalae are put into boiler, add the water of 2-4 times of weight to be distilled, take volatile matter distillation Oil solution, another device are sealed spare；The dregs of a decoction after by distillation add water, decoct 0.5-2 it is small when, stand 5-15 it is small when after filter Juice is taken, receipts fill to be concentrated；2) Radix Salviae Miltiorrhizae, radix pseudostellariae, Herba Epimedii, Poria cocos are put into decoction pot, add boiling 1-3 times, when keeping boiling 0.5-1.5 small Afterwards, treat natural cooling after leaching juice, merge each secondary decocting liquid, stand 3-8 it is small when after after leaching juice, receipts fill making to be mixed；3) volatile matter distillation oil solution and filtered fluid that step 1) obtains are mixed with the filtered fluid that step 2) obtains, takes low temperature to subtract Concentration method is pressed, it is filling to be carried out after the liquid of 1.0-1.2 to be concentrated into proportion.
- 9. preparation method according to claim 8, it is characterised in that comprise the following steps：1) Schisandra chinensis, radix bupleuri, dried orange peel, Rhizoma Atractylodis Macrocephalae are put into boiler, add the water of 3 times of weight to be distilled, take volatile matter distillation oily Solution, another device are sealed spare；The dregs of a decoction after by distillation add water, decoct 1 it is small when, stand 10 it is small when after filter to take juice, receive Fill to be concentrated；2) Radix Salviae Miltiorrhizae, radix pseudostellariae, Herba Epimedii, Poria cocos are put into decoction pot, add boiling 2 times, when keeping boiling 1 small after, treat nature Cooling merges decocting liquid twice after leaching juice, stand 6 it is small when after after leaching juice, receipts fill making to be mixed；3) volatile matter distillation oil solution and filtered fluid that step 1) obtains are mixed with the filtered fluid that step 2) obtains, takes low temperature to subtract Concentration method is pressed, it is filling to be carried out after 1.1 liquid to be concentrated into proportion.
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| US20080241286A1 (en) * | 2005-10-08 | 2008-10-02 | Shengbo Qu | Chinese Medicinal Compositions Useful as Anti-Fatigue, Anti-Aging and Gonadotrophic Agent and Processes for Preparation Thereof |
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