CN100364450C - Alcohol-dissolving liver-protecting healthy food - Google Patents

Abstract

The present invention discloses an alcohol-dissolving liver-protecting healthy food which comprises the following raw materials: 35 to 45 parts by weight of hedgehog fungus, 25 to 35 parts by weight of kudzuvine root, 16 to 24 parts by weight of oyster, 8 to 12 parts by weight of licorice root, 8 to 12 parts by weight of white peony root and 8 to 12 parts by weight of nutgrass flatsedge rhizome. The alcohol-dissolving liver-protecting healthy food can be made into capsules, tablets, pills, medicinal granules or other dosage forms. The alcohol-dissolving liver-protecting healthy food of the present invention has the efficiency of sobering up, promoting digestion, smoothing the liver, relieving acid making, diminishing inflammation, alleviating pain, relieving flatulence, removing the sensation of fullness and improving appetite, and has peculiar therapeutic effect on gastrointestinal symptoms caused by excess wine drinking. After being taken, the alcohol-dissolving liver-protecting healthy food can quickly relieve discomfort, and the total effective rate of the alcohol-dissolving liver-protecting healthy food can reach 93.8%. The alcohol-dissolving liver-protecting healthy food has an obvious protective function for alcoholic liver injury and can be used for treating alcoholism and alcoholic fatty livers. The alcohol-dissolving liver-protecting healthy food has the advantages of high safety and reliability of administration and no toxic or side effect.

Description

Alcohol-dissolving liver-protecting healthy food

Technical field

The present invention relates to a kind of alcohol-dissolving liver-protecting healthy food.

Background technology

Nearly more than 8,000 ten thousand people of China's Patients with Fatty Liver, and the illness rate of alcoholic fatty liver is up to 23.34%.Alcoholism, alcohol dependence, alcoholic fatty liver are one of current social concerns, also lack specific methods of treatment at present.03102025.9 disclose a kind of pharmaceutical composition that is used for the alcohol fatty hepatopathy, it is the medicine of a kind of Chinese and Western combination, Western medicine wherein is a metadoxine, the Chinese medicine dry extract is made of following component and weight ratio: red sage root 30-50 part, rhizoma alismatis 30-50 part, hawthorn 30-50 part, radix bupleuri 15-25 part.In prior art, also there is not a kind of alcohol-dissolving liver-protecting healthy food with health role by pure Chinese medicine preparation without any side effects.

Summary of the invention

The object of the present invention is to provide a kind of alcohol-dissolving liver-protecting healthy food with health role by pure Chinese medicine preparation without any side effects.

The present invention is made of following component and weight ratio:

16～24 parts of 25～35 portions of oysters of 35～45 parts of roots of kudzu vine of Hericium erinaceus

8～12 parts of 8～12 portions of rhizoma cyperis of 8～12 portions of root of herbaceous peonys of Radix Glycyrrhizae

The preferred weight ratio of the present invention is:

18～22 parts of 28～32 portions of oysters of 38～42 parts of roots of kudzu vine of Hericium erinaceus

9～11 parts of 9～11 portions of rhizoma cyperis of 9～11 portions of root of herbaceous peonys of Radix Glycyrrhizae

This has and can make capsule formulation, also can make pill, electuary or other formulation.

Monarch drug in a prescription in the Hericium erinaceus side of being in the present invention's prescription, nature and flavor are sweet flat, go into spleen, stomach, kidney three warps, and function strengthens the spleen and stomach, and marrow is filled out in kidney tonifying.Record in " Xinhua book on Chinese herbal medicine outline ": functions such as " liver, anticancer are held up in favourable the five internal organs, aid digestion, nourishing the liver ".It contains outside polysaccharide, the polypeptide, also contains multivitamin, 18 seed amino acids, and protein content reaches more than 20%, and the element that these materials are consumed after drinking just.Wherein be rich in nicotinic acid (niacinamide), niacinamide is the raw material of synthetic oxidized form nicotinamide adenine dinucleotide (NAD+), and niacinamide (nicotinic acid) is many more, and NAD+ is many more, and the activity of alcohol dehydrogenase is just strong more, and it is just fast more to be metabolized to acetaldehyde; In like manner, the coenzyme of acetaldehyde dehydrogenase also is an oxidized form nicotinamide adenine dinucleotide (NAD+), niacinamide (nicotinic acid) is many more, NAD+ synthetic in the body is just many more, the activity of acetaldehyde dehydrogenase is just strong more, it is just fast more to be metabolized to nontoxic acetate, has so just removed acetaldehyde and the ethanol toxic action to body.The metabolism of accelerating alcohol and acetaldehyde is metabolized to avirulence acetate, the purpose that reaching relieves the effect of alcohol holds up liver.Vit C contents is up to 26mg/100g in the Hericium erinaceus, and vitamin C has anti-oxidant, removes the function of free radical.Ethanol and acetaldehyde all can produce free radical in metabolic process, and the radical pair body can cause very big damage.Vitamin C is removed free radical, and the protection body is avoided the damage of free radical, the purpose that reaching relieves the effect of alcohol holds up liver.

Ministerial drug in the root of kudzu vine side of being, effect energy relieving muscles diaphoresis, promoting eruption, the relieving restlessness that promotes the production of body fluid to quench thirst rises positive antidiarrheal, and the treatment sore of invigorating blood circulation is relieved the effect of alcohol.The mouse SGPT that root of kudzu vine extract can obviously reduce due to carbon tetrachloride and the ethanol raises, suppress the generation of liver cell MDA MDA (MDA), the liver glycogen that improves due to four carbonoxides reduces, and alleviates pathology of livers, and the prompting root of kudzu vine has protective action to hepatic injury.Have and discover that root of kudzu vine extract has the obvious suppression effect to the central nervous system of mice excitement that the low dosage ethylism causes, and rat and the central nervous system of mice that the high dose ethylism causes suppressed phenomenon, certain antagonism is then arranged, the effect that the root of kudzu vine has relieving alcoholism and sobers up is described.

Oyster contains calcium carbonate, calcium phosphate and the calcium sulfate of 80--85%, and contains magnesium, aluminium, silicon etc., is rich in the trace element and the vitamin of multiple needed by human such as calcium, zinc, phosphorus, iron, magnesium, vitamin D, amino acid.Oyster shell calcium is the natural materials that has activated, and contains the natural mineral matter of trace, very easily be absorbed by the body, and be very superior nutrient.There are description of test oyster and extract taurine thereof can effectively prevent and treat the rat alcoholic fatty liver.Oyster contains a large amount of mineral matters; and mineral matter is the element that is consumed after drinking; also can in and hydrochloric acid in gastric juice; reduce pepsin activity; the protection gastric mucosa; relax the stimulation of alcohol, and be rich in the trace element and the vitamin of multiple needed by human such as calcium, zinc, phosphorus, iron, magnesium, vitamin D, amino acid, Antialcoholic liver-protecting is played crucial effect stomach.

Radix Glycyrrhizae, the root of herbaceous peony, rhizoma cyperi are for making medicine in the side.The Radix Glycyrrhizae nature and flavor are sweet, flat, main spleen, lung, the heart channel of Hang-Shaoyin of returning.The invigorating the spleen of function will and spirit, relieving spasm to stop pain, expelling phlegm and arresting coughing, clearing heat and detoxicating, relax the property of medicine.Enoxolone, glycyrrhizin all have certain detoxification ability to some drugs poisoning, alcoholism, interior metabolism product poisoning.Root of herbaceous peony property hardship, acid, be slightly cold main returning through, the spleen channel.The function suppressing liver-YANG, the astringe yin that nourishes blood, easing the affected liver to relieve pain.Rhizoma cyperi nature and flavor suffering, little hardship, little sweet flat, main liver, the spleen tri-jiao channel of returning.The function dispersing stagnated hepatoqi, menstruction regulating and pain relieving.Radix Glycyrrhizae, the root of herbaceous peony, rhizoma cyperi three flavors are clearing heat and detoxicating, support protecting liver, and all medicines share, and play the effect that Dealcoholic sobering-up, nourishing the liver are held up liver altogether.Experiment showed, that by human experiment the present invention really can Dealcoholic sobering-up, alcoholic liver injury is had auxiliary protection function.

The health food made by above component has Dealcoholic sobering-up, the liver of relaxing of being good for the stomach, and the gastrointestinal symptoms that causes drinking beyond one's capacity, special effect can be removed the sense of discomfort rapidly after taking medicine.Alcoholic liver injury there is significant protective effect, can be used for treating alcoholism, alcoholic fatty liver.Each component is the raw material of medicine-food two-purpose in the present invention's prescription, does not contain any chemical addition agent, takes safe and reliable, without any side effects.

The specific embodiment

Embodiment 1: the Antialcoholic liver-protecting capsule

Get Hericium erinaceus 40kg root of kudzu vine 30kg oyster 20kg

Radix Glycyrrhizae 10kg root of herbaceous peony 10kg rhizoma cyperi 10kg

The preparation method may further comprise the steps:

1. the Hericium erinaceus water with half extracts 3 times: add 8 times of water gagings at every turn, be heated to 100 ℃, each 1 hour, merge extract, filter, be concentrated into the crude drug that every 1g soup is equivalent to 1.4g, again with second half Hericium erinaceus meal mixing, oven dry, steam sterilizing (121 ℃, 0.5h), sealing, standby;

2. calcined oyster shell is pulverized, and steam sterilizing (121 ℃, 0.5h), oven dry, sealing, standby;

3. the root of kudzu vine, Radix Glycyrrhizae, rhizoma cyperi (system), the root of herbaceous peony (system) carry out water extraction 3 times by recipe quantity, add 8 times in water at every turn, extract 1 hour at every turn, and heating (100 ℃) merges extract, filters, and filtrate is concentrated into the crude drug that every 1g soup is equivalent to 1.5g;

4. with above each component mixing, oven dry is pulverized, and crosses 100 mesh sieves, makes capsule by prior art, every 0.42g.

The test-meal result is as follows:

Eating method and amount: take each 4～6 before the wine

Eating effect such as following table:

	Total routine number	The produce effects number	Obvious effective rate (%)	Significant figure	Efficient (%)	Total effective rate (%)	Invalid number	Inefficiency (%)
									The test-meal group	130	83	63.8	39	30.0	93.8	8	6.2

The result finds out by test-meal, and this product obvious effective rate reaches 63.8%, and total effective rate reaches 93.8%, illustrates that this product really can Dealcoholic sobering-up, and alcoholic liver injury is had auxiliary protection function.

The animal experiment situation:

Detect through the disease prevention and control center, Sichuan Province, the result reviews as follows: this product per os irritated after stomach gives animal in continuous 30 days, body weight, the liver of animal heavily reached liver body ratio do not have obvious influence, GSH has remarkable rising in the middle dosage group LH, the MDA of three dosage groups, TG have downward trend and low, middle dosage group to have conspicuousness to reduce (P＜0.05, P＜0.01), the histopathological examination result is positive.This shows that the Antialcoholic liver-protecting capsule has assistant protection function to the animal alcoholic liver injury.

The result is as follows for the security toxicology test:

Detect through the disease prevention and control center, Sichuan Province, the result reviews as follows: the Antialcoholic liver-protecting capsule belongs to nontoxic level to large and small mouse acute oral toxicity test MTD＞16000mg/kg.bw as a result by the acute toxicity classification.

Three genetic toxicity tests (Salmonella reversion test, PCEMNR micronucleus test, mouse sperm deformity test), not opinion bartender capsule for protecting liver mutagenesis of result.

30 days feeding trials, visible animal growth is normal, and body weight sustainable growth, figure are active, smooth submissive by hair, do not see that poisoning symptom and death appear in animal.Body weight, food utilization, dirty body ratio to animal do not have obvious influence.

Hematology conventional detection and blood biochemistry index testing result are removed female mouse high dose and are organized acid anhydride to be starkly lower than control group, but institute's measured value is still in this chamber range of normal value, all the other every indexs of each dosage group and control group comparison no significant difference.The histopathological examination result is except that the spontaneous pathology of animal, and opinion bartender capsule for protecting liver high dose group does not cause that the animal toxic injury changes.

Embodiment 2: the Antialcoholic liver-protecting tablet

Sampling situation as different from Example 1 is

Hericium erinaceus 45kg root of kudzu vine 25kg oyster 18kg

Radix Glycyrrhizae 8kg Chinese herbaceous peony 8kg rhizoma cyperi 10kg

Preparation method's the 1.2.3 step is identical, and the 4th step, oven dry was pulverized with above each component mixing, behind 100 mesh sieves, be prepared into tablet by existing method again.

Claims (2)

1. alcohol-dissolving liver-protecting healthy food is characterized in that: constitutes by following component and weight ratio,

16～24 parts of 25～35 portions of oysters of 35～45 parts of roots of kudzu vine of Hericium erinaceus

8～12 parts of 8～12 portions of rhizoma cyperis of 8～12 portions of root of herbaceous peonys of Radix Glycyrrhizae;

And the following method of process is prepared from:

1. the Hericium erinaceus water with half extracts 3 times, adds 8 times of water gagings at every turn, is heated to 100 ℃, each 1 hour, merge extract, filter, be concentrated into the crude drug that every 1g soup is equivalent to 1.4g, again with second half Hericium erinaceus meal mixing, oven dry, through steam sterilizing, sealing, standby;

2. calcined oyster shell is pulverized, steam sterilizing, oven dry, sealing, standby;

3. the root of kudzu vine, Radix Glycyrrhizae, rhizoma cyperi, the root of herbaceous peony carry out water extraction 3 times by recipe quantity, add 8 times in water at every turn, extract 1 hour at every turn, 100 ℃ of heating, merge extract, filter, and filtrate is concentrated into the crude drug that every 1g soup is equivalent to 1.5g;

4. with above each component mixing, oven dry is pulverized, and crosses 100 mesh sieves, makes capsule, pill, electuary or other formulation by prior art.

2. health food according to claim 1, optimum weight ratio is:

18～22 parts of 28～32 portions of oysters of 38～42 parts of roots of kudzu vine of Hericium erinaceus

9～11 parts of 9～11 portions of rhizoma cyperis of 9～11 portions of root of herbaceous peonys of Radix Glycyrrhizae.