CN104083748A - Traditional Chinese medicine formula for treating sour regurgitation caused by deficiency of gastric dynamics - Google Patents
Traditional Chinese medicine formula for treating sour regurgitation caused by deficiency of gastric dynamics Download PDFInfo
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- CN104083748A CN104083748A CN201410372041.3A CN201410372041A CN104083748A CN 104083748 A CN104083748 A CN 104083748A CN 201410372041 A CN201410372041 A CN 201410372041A CN 104083748 A CN104083748 A CN 104083748A
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Abstract
The invention discloses a traditional Chinese medicine formula for treating sour regurgitation caused by deficiency of gastric dynamics. The medicine according to the traditional Chinese medicine formula is characterized by being prepared from the following traditional Chinese medicine raw materials in parts by weight: 10 parts of radix bupleuri, 10 parts of codonopsis pilosula, 15 parts of pinellia ternate, 15 parts of mangnolia officinalis, 10 parts of scutellaria baicalensis, 6 parts of licorice root, 10 parts of cassia twig, 10 parts of radix paeoniae alba, 20 parts of radix puerariae, 3 parts of fresh ginger and 3 parts of Chinese date. The traditional Chinese medicine formula for treating the sour regurgitation caused by the deficiency of gastric dynamics has the advantages of wide medicinal resource, low cost, obvious treatment effect, reliable reaction and the like, and is convenient to prepare and cannot generate a side effect.
Description
Technical field:
The present invention relates to Chinese medicine technical field, particularly a kind of Chinese medicinal formulae for the treatment of gastric dynamic dysfunction and cause acid regurgitation.
Background technology:
In overall digestion process after mankind's pickuping food, if will causing gastric emptying to slow down, gastric dynamic dysfunction can cause food holdup time prolongation under one's belt, gastric acid secretion increases, and then cause mucosa to damage, in the course of time, easily produce the various symptoms such as gastritis, abdominal distention, dyspepsia, constipation, and this wherein acid regurgitation be that gastroxia is exactly the most common and endangers maximum symptom, long-term gastroxia can cause great infringement to gastric mucosa, brings out the even serious consequence such as gastric perforation of gastric ulcer.And in modern medicine, be often that to take medicine for stomach dynamic accelerate gastrointestinal emptying, strengthen stomach function; Take intestinal microbial population regulator with regulating intestinal canal flora; Take digestant and help digestive function, but cause that for gastric dynamic dysfunction the treatment of acid regurgitation all exists the deficiency of curing the symptoms, not the disease.
Summary of the invention:
The present invention is exactly in order to overcome deficiency of the prior art, provide a kind of for gastric dynamic dysfunction cause the treatment of acid regurgitation have that preparation is convenient, medicine source is wide, cost is low, evident in efficacy, and reliable effect, the Chinese medicinal formulae that has no side effect.
The invention provides following technical scheme:
Treating gastric dynamic dysfunction causes and it is characterized in that the Chinese medicinal formulae of acid regurgitation being made up of the raw material of Chinese medicine of following composition by weight: Radix Bupleuri 5-20 part, Radix Codonopsis 5-20 part, Rhizoma Pinelliae 5-20 part, Cortex Magnoliae Officinalis 5-20 part, Rhizoma Atractylodis 5-20 part, Radix Scutellariae 5-20 part, Radix Glycyrrhizae 5-10 part, Ramulus Cinnamomi 5-20 part, Radix Paeoniae Alba 5-20 part, Radix Puerariae 15-30 part, Rhizoma Zingiberis Recens 2-5 part, Fructus Jujubae 2-10 part.
Formula optimization is:
10 parts of Radix Bupleuri, 10 parts of Radix Codonopsis, 15 parts of the Rhizoma Pinelliaes, 15 parts of Cortex Magnoliae Officinalis, 15 parts of Rhizoma Atractylodis, 10 parts of Radix Scutellariaes, 6 parts, Radix Glycyrrhizae, 10 parts of Ramulus Cinnamomi, 10 parts of the Radix Paeoniae Albas, 20 parts of Radix Puerariaes, 3 parts, Rhizoma Zingiberis Recens, 3 parts, Fructus Jujubae.
Preparation method:
Get above-mentioned each raw material of Chinese medicine by above-mentioned composition by weight, first by Removing Kernel for Date, be ground into 600 order fine powders for subsequent use, falling other each raw material of Chinese medicine adds 5 times of decoctings to boil 2 hours again, then medicinal liquid leaches for subsequent use, will add 3 times of decoctings to boil 1 hour in medicinal residues, medicinal liquid is leached, the medicinal liquid leaching for twice is merged, be concentrated into original volume 50% after add Fructrs Jujubae Powder and carrageenan to carry out centrifugal mixer processing, then be condensed into again the thick paste of 1.115-1.130, then add therein additive conventional in pharmaceutics, then make common formulations.The raw material of Chinese medicine of above-mentioned weight proportion can be made the medication of 1 course for the treatment of.
Method of administration:
When 0.5 hour after meal-0.45 hour every day, take medicine 1 time, each serving with 5 grams, serveing on 5 days is a course for the treatment of.
Form being described in detail as follows of each raw material of Chinese medicine of the present invention:
Radix Bupleuri: bitter in the mouth, cold nature.Return liver, gallbladder meridian.There is reconciling superficies and interior, soothing the liver, the effects such as yang invigorating.Be usually used in cold, fever, alternate attack of chill and fever, distending pain in the chest and hypochondrium, menoxenia, sub-official's prolapsus, the diseases such as proctoptosis.The effective ingredient of this product: volatile oil (eugenol, acid, r-undecanoic acid lactone and to methoxybenzene diketone), saikoside.Effect: heating due to typhoid fever, paratyphoid fever vaccine, escherichia coli liquid, fermented milk, yeast etc. is had to trivial solution heat effect; And can make animal normal body temperature decline.Saikosaponin decoct 2g/kg is to rabbit gavage, to all having obvious refrigeration function with the heating that vaccine and temperature thorn cause; Antiinflammatory, effective ingredient: saponin.Effect: swollen and desmoplastic inflammation all has inhibitory action to ankle joint due to multiple proinflammatory agent.Saikoside 300mg/kg lumbar injection, can suppress the rat paw edema that carrageenin, 5-hydroxy tryptamine, histamine cause, suppresses rat granuloma swollen, can make adrenal gland's hypertrophy, atrophy of thymus gland simultaneously; Inflammation-inhibiting is organized histamine release and leukoplania; Promote immunity function, effective ingredient: Bupleurum chinense polysaccharide.Effect: phagocytic function strengthens, Natural killer activity strengthens, and improves special viral antibody titre, improves lymphocyte and turns core rate, improves skin delayed hypersensitivity reaction; Anti-liver injury, an injection of Radix Bupleuri 1 ml/ subcutaneous injection can significantly reduce the rat blood serum rising that carbon tetrachloride causes for continuous 5 days, and hepatocellular degeneration and necrosis also obviously alleviate, and in hepatocyte, glycogen and rna content also approach normal; Antiradiation injury, a Bupleurum chinense polysaccharide 5mg/ lumbar injection, can improve and irradiate the survival rate of mice, in mouse chest cell 3H-TdR mix increase, accelerate the release of thymocyte cell simultaneously, make again skin in blood plasma simultaneously.Matter ketone content increases, and after adrenalectomize, no longer includes these performances, therefore think to realize by adrenal cortex.In addition, external have an anti-tubercle bacillus effect.
Radix Codonopsis: sweet in the mouth, property is flat.Return spleen, lung meridian.There is invigorating the spleen and replenishing QI, the effects such as spleen invigorating lung benefiting.Be usually used in deficiency of the spleen and lung, the cardiopalmus of breathing hard, anorexia and loose stool, dyspnea due to deficiency cough, the interior-heat disease such as quench one's thirst.Oral or the subcutaneous injection of the alcohol of Radix Codonopsis root, aqueous extract, can make the erythrocyte of normal rabbit and the effect that hemoglobin slightly increases.In addition, also there is the effect such as blood sugar lowering, blood pressure lowering.
The Rhizoma Pinelliae: acrid in the mouth, warm in nature; Poisonous.Return spleen, stomach, lung meridian.There is drying dampness to eliminate phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, the effects such as dissolving lump and resolving mass.Be usually used in abundant expectoration cough with asthma, phlegm retention vertigo and palpitation, dizziness due to wind-phlegm, syncope due to accumulation of phlegm headache, vomiting regurgitation, breast gastral cavity painful abdominal mass is vexed, globus hystericus; Raw with diseases such as external treatment carbuncle sucutaneous nodule.Experiment shows: the Rhizoma Pinelliae can promote rabbit bile secretion, can make corticosterone in Mouse Blood increase, and strengthens the inducing action of corticosterone to TYR transaminase in liver, TYR transaminase's activity in rising liver; The Rhizoma Pinelliae has the effect that more obviously reduces triglyceride and low density lipoprotein, LDL, can reduce whole blood viscosity, suppresses erythrocytic gathering and improve erythrocyte deformability; The Rhizoma Pinelliae 75% ethanol extraction is to mouse stomach, and energy significant prolongation mice stimulates the incubation period of whipping reaction to burning pain, reduce the mouse writhing reaction times being caused by acetic acid.In addition, this product also has the effect such as blood pressure lowering and short cell division.
Cortex Magnoliae Officinalis: bitter in the mouth; Pungent; Warm in nature.Return spleen, stomach, large intestine channel.There is circulation of qi promoting removing food stagnancy; Dampness is except full; The effects such as lowering the adverse QI to relieve asthma.Be mainly used in treating stagnation of QI due to dyspepsia; Abdominal distention constipation; Retention of dampness in middle-JIAO, gastral cavity painful abdominal mass is vomited and diarrhoea; Expectorant is stopped up QI rising in reverse order; The fullness in the chest disease such as breath with cough.This product experiment in vitro proves, Cortex Magnoliae Officinalis decoct all has antibacterial action to gram negative bacillis such as the gram positive bacterias such as staphylococcus, Hemolytic streptococcus, streptococcus pneumoniae, bordetella pertussis and anthrax bacillus, dysentery bacterium, Bacillus typhi, Salmonella paratyphi, vibrio cholera, escherichia coli, Bacillus proteus, bacillus subtilis.Experiment shows, compares with other 61 kinds of Chinese medicines, and Cortex Magnoliae Officinalis is the strongest to the effect of Staphylococcus albus, bacillus subtilis, escherichia coli and Bacillus typhi, its bactericidal action that act as to Staphylococcus albus and bacillus subtilis.In addition, the intestine in vitro of Cortex Magnoliae Officinalis decoct to mice and Cavia porcellus, low dose of appearance is excited, and heavy dose, for suppressing, also has excitation to guinea pig bronchial smooth muscle.
Rhizoma Atractylodis: acrid in the mouth, hardship, warm in nature.Return spleen, stomach, Liver Channel.There is the effects such as drying damp and strengthening spleen, expelling wind and cold, improving eyesight.Be usually used in distension and fullness in the abdomen, have loose bowels, edema, beriberi flaccidity of feet with lamenness, rheumatic arthralgia, anemofrigid cold, the diseases such as nyctalopia.Rhizoma Atractylodis extractum intravenous injection in a small amount, causes the slight rising of Sanguis Leporis seu oryctolagi pressure, blood pressure lowering in a large number; Isolated Toad Heart is had to inhibitory action; Isolated rabbit duodenum is also had to inhibitory action; To Bufo siccus lower limb vascular, act on faint.
Radix Scutellariae: bitter in the mouth, cold in nature.Return lung, gallbladder, spleen, large intestine, small intestine meridian.There is heat clearing and damp drying, eliminating fire and detoxication, hemostasis, the effect such as antiabortive.Be usually used in hygropyrexia, fever disease in summer vomiting and nausea uncomfortable in chest, damp and hot feeling of fullness, dysentery, jaundice, cough due to lung-heat, high hot excessive thirst, heat in blood is told nosebleed, carbuncle sore tumefacting virus, the diseases such as frequent fetal movement.The effects such as that this product also has is antibacterial, antifungal, antiviral, antiplatelet aggregation and anticoagulant, antiinflammatory antiallergic action, antimicrobial, antipyretic, blood pressure lowering, diuresis and gallbladder, spasmolytic, calmness.In addition, the clinical antibiotic property of Radix Scutellariae is better than Rhizoma Coptidis, and does not develop immunity to drugs.
Radix Glycyrrhizae: sweet in the mouth, property is flat.Return stomach, lung, spleen channel.There is invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, the effects such as coordinating the actions of various ingredients in a prescription.Be usually used in weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, the anxious pain of gastral cavity abdomen, extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, the disease such as strong.This product has removing toxic substances, eliminates the phlegm, pain relieving, spasmolytic, anticancer, regulate the pharmacological actions such as body's immunity, arrhythmia, blood fat reducing, atherosclerosis, anticoagulant, antitumor.
Ramulus Cinnamomi: acrid in the mouth, sweet, warm in nature.GUIXIN, lung, urinary bladder channel.There is diaphoresis expelling pathogenic factors from muscles, warming the meridian and promoting blood circulation, supporing yang activating QI, the effects such as dispersing cold for relieving pain.Be usually used in anemofrigid cold, coldness and pain in the epigastrium, cold in blood amenorrhea, arthralgia, phlegm retention, edema, cardiopalmus, the diseases such as renal mass.This product also has blood vessel dilating, regulates blood circulation, antipyretic, analgesia, calmness, convulsion, antiinflammatory, antiallergic, the effect such as antibacterial.
The Radix Paeoniae Alba: cool in nature, bitter in the mouth acid, is slightly cold, and has blood-supplementing blood-nourishing, suppressing liver-YANG, easing the affected liver to relieve pain.The effects such as astringing YIN to stop sweating, are applicable to fever due to yin deficiency, menoxenia, the breast abdomen pain over the hypochondriac region, extremity contraction anxious, dysentery stomachache, spontaneous sweating, metrorrhagia, are with inferior disease.In this product, contained paeoniflorin has antibacterial, antipyretic, antiinflammatory, increase coronary flow, improves the effect of myocardial nutritional flow, blood vessel dilating, antagonism acute myocardial ischemia, anticoagulant, calmness, analgesia, spasmolytic, antiulcer, adjusting blood glucose; Radix Paeoniae Alba decoct can suppress dysentery bacterium, streptococcus pneumoniae, escherichia coli, Bacillus typhi, Hemolytic streptococcus, bacillus pyocyaneus etc.In addition, research shows: the Radix Paeoniae Alba has potentiation to the phagocytic function of macrophage.
Radix Puerariae: sweet in the mouth, pungent, cool in nature.Return spleen, stomach warp.There is expelling pathogenic factors from muscles for reducing heat, promote the production of body fluid, rash, the effects such as yang invigorating antidiarrheal.Be usually used in fever caused by exogenous pathogens headache, stiff nape and back, thirsty, quench one's thirst, measles without adequate eruption, hematodiarrhoea, has loose bowels; The diseases such as hypertension neck pain.The flavone proposing in Radix Puerariae can increase brain and crown vascular flow amount, also has the effects such as antipyretic, antiinflammatory, antibacterial, enhancing immunity.
Rhizoma Zingiberis Recens: acrid in the mouth, slightly warm in nature.Return lung, spleen, stomach warp.There is the cold expelling of inducing sweat, warming middle-JIAO to arrest vomiting, the effects such as preventing phlegm from forming and stopping coughing.Be usually used in anemofrigid cold, gastrofrigid vomiting, the diseases such as cold-phlegm cough.The extracting solution of this product has excitation to anesthetized cat vasomotor center and respiratory center, and heart is also had to direct excitation; In vitro tests water logging agent has inhibitory action to trichophyton, and trichomonas vaginitis is had to killing action; The effects such as blood pressure lowering.
Fructus Jujubae: sweet in the mouth, warm in nature.Return spleen, stomach warp.There is invigorating the spleen and replenishing QI, the effects such as nourishing blood to tranquillize the mind.Be usually used in insufficiency of the spleen lack of appetite, weak loose stool, the diseases such as woman hysteria.The cyclic adenosine monophosphate that Fructus Jujubae is contained, is the essential composition of human body cell energy metabolism, can muscle strength reinforcing, allaying tiredness, blood vessel dilating, increase myocardial contraction, improve myocardial nutrition, control cardiovascular system diseases is had to good effect; Chinese medicine theory thinks, Fructus Jujubae has the effects such as tonify deficiency QI invigorating, nourishing blood to tranquillize the mind, invigorating the spleen and regulating the stomach, and Fructus Jujubae has good therapeutic effect to diseases such as chronic hepatitis, liver cirrhosis, anemia, anaphylactoid purpura; Fructus Jujubae contains triterpenoid compound and cyclic adenosine monophosphate, has stronger anticancer, anti-allergic effects.
fructus Jujubaecan moisten cardiopulmonary, cough-relieving, tonifying five ZANG-organs, control deficient, except the intestines and stomach addiction gas, can also regulating the spleen and stomach support spleen, flat gastric qi, logical nine orifices, help 12 through etc.
The present invention for gastric dynamic dysfunction cause the treatment of acid regurgitation have that preparation is convenient, medicine source is wide, cost is low, evident in efficacy, and reliable effect, the advantage such as have no side effect.
Detailed description of the invention:
Embodiment 1:
Treating gastric dynamic dysfunction causes and it is characterized in that the Chinese medicinal formulae of acid regurgitation being made up of the raw material of Chinese medicine of following composition by weight: 10 parts of Radix Bupleuri, 10 parts of Radix Codonopsis, 15 parts of the Rhizoma Pinelliaes, 15 parts of Cortex Magnoliae Officinalis, 15 parts of Rhizoma Atractylodis, 10 parts of Radix Scutellariaes, 6 parts, Radix Glycyrrhizae, 10 parts of Ramulus Cinnamomi, 10 parts of the Radix Paeoniae Albas, 20 parts of Radix Puerariaes, 3 parts, Rhizoma Zingiberis Recens, 3 parts, Fructus Jujubae.
Embodiment 2:
Treating gastric dynamic dysfunction causes and it is characterized in that the Chinese medicinal formulae of acid regurgitation being made up of the raw material of Chinese medicine of following composition by weight: 5 parts of Radix Bupleuri, 5 parts of Radix Codonopsis, 10 parts of the Rhizoma Pinelliaes, 10 parts of Cortex Magnoliae Officinalis, 10 parts of Rhizoma Atractylodis, 5 parts of Radix Scutellariaes, 6 parts, Radix Glycyrrhizae, 5 parts of Ramulus Cinnamomi, 5 parts of the Radix Paeoniae Albas, 15 parts of Radix Puerariaes, 2 parts, Rhizoma Zingiberis Recens, 2 parts, Fructus Jujubae.
Embodiment 3:
Treating gastric dynamic dysfunction causes and it is characterized in that the Chinese medicinal formulae of acid regurgitation being made up of the raw material of Chinese medicine of following composition by weight: 20 parts of Radix Bupleuri, 20 parts of Radix Codonopsis, 20 parts of the Rhizoma Pinelliaes, 20 parts of Cortex Magnoliae Officinalis, 20 parts of Rhizoma Atractylodis, 20 parts of Radix Scutellariaes, 10 parts, Radix Glycyrrhizae, 15 parts of Ramulus Cinnamomi, 15 parts of the Radix Paeoniae Albas, 30 parts of Radix Puerariaes, 5 parts, Rhizoma Zingiberis Recens, 10 parts, Fructus Jujubae.
General data: the Chinese medicinal formulae that uses embodiment 1 to prepare is applied to observes case 159 examples, wherein male 83 examples, female's 76 examples, wherein age level is between 20-55 year.
Diagnosis basis:
1, distension and fullness in the abdomen, often accompanies that painful abdominal mass is vexed, the disease such as belch, pantothenic acid, noisy, nausea and vomiting.2, morbidity normal with feelings will not freely, eating and drinking without temperance, fatigue, the factor such as catch cold be relevant.
Period in a medicine: avoid tobacco and wine, eat the thing of raw and cold, pungent, stimulation and delicious food.
Criterion of therapeutical effect:
Cure: distension and fullness in the abdomen and other transference cure.
Take a turn for the better: distension and fullness in the abdomen and acid regurgitation are alleviated, and attack times reduces other symptoms and alleviates.
Invalid: symptom is without improvement.
Therapeutic effect: in this clinical observation case, take medicine 1～5 course for the treatment of, recovery from illness 95 examples, 60 examples that take a turn for the better, invalid 4 examples, and there is not toxic and side effects during treatment.
Model case:
Case 1: patient Lee, man, 20 years old.Often feel abdominal part distension, on gastric acid, gush, diarrhea with loose stool acid is smelly, and oliguria with yellow urine is as water from washing rice.Red tongue, greasy fur, slippery and rapid pulse.After 2 courses for the treatment of of medicament of taking prepared by Chinese medicinal formulae of the present invention, on distension and fullness in the abdomen, gastric acid, gush and have clear improvement, appetite strengthens, and stool acid smell alleviates; Continue to take after 2 courses for the treatment of, distension and fullness in the abdomen and acid regurgitation transference cure, sleep is good, and diet is normal, recovery from illness.Follow up a case by regular visits to over 2 years and do not recur.
Case 2: patient Liu so-and-so, female, 33 years old, just feel after meal that for many years gastric is if any " admant ", it is unfavorable to digest, and with symptoms such as acid regurgitations.After 2 courses for the treatment of of medicament of taking prepared by Chinese medicinal formulae of the present invention, on distension and fullness in the abdomen, gastric acid, gush and have clear improvement, appetite strengthens, and stool acid smell alleviates; Continue to take after 4 courses for the treatment of, distension and fullness in the abdomen and acid regurgitation transference cure diet are normal, recovery from illness.Follow up a case by regular visits to over 2 years and do not recur.
Claims (2)
1. treating gastric dynamic dysfunction causes and it is characterized in that the Chinese medicinal formulae of acid regurgitation being made up of the raw material of Chinese medicine of following composition by weight: Radix Bupleuri 5-20 part, Radix Codonopsis 5-20 part, Rhizoma Pinelliae 5-20 part, Cortex Magnoliae Officinalis 5-20 part, Rhizoma Atractylodis 5-20 part, Radix Scutellariae 5-20 part, Radix Glycyrrhizae 5-10 part, Ramulus Cinnamomi 5-20 part, Radix Paeoniae Alba 5-20 part, Radix Puerariae 15-30 part, Rhizoma Zingiberis Recens 2-5 part, Fructus Jujubae 2-10 part.
2. according to described in claim 1, a kind of Chinese medicinal formulae for the treatment of gastric dynamic dysfunction and cause acid regurgitation, it is characterized in that being made up of the raw material of Chinese medicine of following composition by weight: 10 parts of Radix Bupleuri, 10 parts of Radix Codonopsis, 15 parts of the Rhizoma Pinelliaes, 15 parts of Cortex Magnoliae Officinalis, 15 parts of Rhizoma Atractylodis, 10 parts of Radix Scutellariaes, 6 parts, Radix Glycyrrhizae, 10 parts of Ramulus Cinnamomi, 10 parts of the Radix Paeoniae Albas, 20 parts of Radix Puerariaes, 3 parts, Rhizoma Zingiberis Recens, 3 parts, Fructus Jujubae.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104840653A (en) * | 2015-06-03 | 2015-08-19 | 淄博齐鼎立专利信息咨询有限公司 | Medicine preparation for treating sour regurgitation of stomachs |
| CN108686070A (en) * | 2018-07-16 | 2018-10-23 | 资兴市泰坤农林生态产业有限公司 | A kind of livestock stomach strengthening and digestion promoting composition and preparation method thereof |
-
2014
- 2014-07-31 CN CN201410372041.3A patent/CN104083748A/en active Pending
Non-Patent Citations (1)
| Title |
|---|
| 凌静: ""小柴胡汤加减治疗胃食管反流病32例"", 《实用中医药杂志》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104840653A (en) * | 2015-06-03 | 2015-08-19 | 淄博齐鼎立专利信息咨询有限公司 | Medicine preparation for treating sour regurgitation of stomachs |
| CN108686070A (en) * | 2018-07-16 | 2018-10-23 | 资兴市泰坤农林生态产业有限公司 | A kind of livestock stomach strengthening and digestion promoting composition and preparation method thereof |
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Application publication date: 20141008 |
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