CN107744586A - A kind of Camellia nitidissima Jiantang Granule and preparation method thereof - Google Patents

A kind of Camellia nitidissima Jiantang Granule and preparation method thereof Download PDF

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CN107744586A
CN107744586A CN201711121164.XA CN201711121164A CN107744586A CN 107744586 A CN107744586 A CN 107744586A CN 201711121164 A CN201711121164 A CN 201711121164A CN 107744586 A CN107744586 A CN 107744586A
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camellia nitidissima
granule
parts
jiantang
preparation
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于大永
郭秀磊
史丽颖
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Dalian University
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Dalian University
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/07—Basidiomycota, e.g. Cryptococcus
    • A61K36/076—Poria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/284—Atractylodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/34—Campanulaceae (Bellflower family)
    • A61K36/346—Platycodon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484—Glycyrrhiza (licorice)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/535—Perilla (beefsteak plant)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/57—Magnoliaceae (Magnolia family)
    • A61K36/575—Magnolia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/75—Rutaceae (Rue family)
    • A61K36/752—Citrus, e.g. lime, orange or lemon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/82—Theaceae (Tea family), e.g. camellia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/888—Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
    • A61K36/8888—Pinellia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/889—Arecaceae, Palmae or Palmaceae (Palm family), e.g. date or coconut palm or palmetto
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/906—Zingiberaceae (Ginger family)
    • A61K36/9068—Zingiber, e.g. garden ginger
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin

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  • Health & Medical Sciences (AREA)
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Abstract

The present invention relates to tcm field, specifically a kind of Camellia nitidissima Jiantang Granule and preparation method thereof.It is made up of following raw material：10 ~ 30 parts of Camellia nitidissima, 1 ~ 10 part of perilla leaf, 15 ~ 30 parts of Poria cocos, 10 ~ 20 parts of dried orange peel, 1 ~ 10 part of the bark of official magnolia, 1 ~ 10 part of balloonflower root, 10 ~ 15 parts of ginger, 1 ~ 10 part of the bighead atractylodes rhizome, 1 ~ 10 part of Rhizoma Pinelliae Fermentata, 1 ~ 5 part of the shell of areca nut, 5 ~ 10 parts of radix glycyrrhizae.Granule component of the present invention is appropriate, reasonable mixture ratio, and have reduces blood glucose effect very well, diabetes is originated with the phase, mid-term, the illness in late period have the effect of notable, and hypoglycemic effect is preferable, and preparation method is simple, convenient to carry out, suitable for large-scale industrial production.

Description

A kind of Camellia nitidissima Jiantang Granule and preparation method thereof
Technical field
The invention belongs to tcm field, specifically a kind of Camellia nitidissima Jiantang Granule and preparation method thereof.
Background technology
In recent years, with the continuous development of society, the living standard more and more higher of people, but this is also resulted in both at home and abroad The number of diabetes is also increasing with surprising rapidity, according to the statistics every 10 minutes phases for just having 1 people to die from diabetes in the whole world The disease of closing property.Diabetes have become the 3rd big disease after cardiovascular and cerebrovascular, cancer.It is present by scientific research Confirm, diabetes be it is a kind of by heredity and environmental factor cause the disease being detrimental to health.It is reported that in 2007, about There are 38,000,000 people to die from the disease, account for the 6% of global general mortality rate.AIDS of this numeral about with 2002 is dead Number is consistent, and this is very fearful.Still more, diabetes can also cause the complication of many.For example, diabetes can cause Sugar, protein, the water-electrolyte metabolism disorder of Secondary cases and the endocrine and metabolic disorders of acid-base imbalance, can trigger when serious The chronic vascular and neural complication of patient, patient is set to disable or dead.Its clinical manifestation it is more to drink more, food, diuresis, body more Become thin as principal character, and it is high with the incidence of disease and issue licence more, the characteristics of can not effecting a radical cure.
At present, the medicine of clinical treatment diabetes is mainly based on insulin, Drugs Promoting Insulin Secretion, biguanides, on Although stating medicine has the effect of fine, but still have some shortcomings, particularly the complication this respect effect in prevention diabetes Fruit is undesirable.It is seldom the preparation of diabetes to be treated with Chinese medicine, and the medical value of Chinese medicine cannot embody, Chinese medicine currently on the market Treatment for diabetes has very big application value.
The content of the invention
The purpose of the present invention aims to provide a kind of Camellia nitidissima Jiantang Granule and preparation method thereof.
For achieving the above object, the present invention adopts the following technical scheme that：
A kind of Camellia nitidissima Jiantang Granule, it is made up of following raw material：10 ~ 30 parts of Camellia nitidissima, 1 ~ 10 part of perilla leaf, Fu 15 ~ 30 parts of Siberian cocklebur, 10 ~ 20 parts of dried orange peel, 1 ~ 10 part of the bark of official magnolia, 1 ~ 10 part of balloonflower root, 10 ~ 15 parts of ginger, 1 ~ 10 part of the bighead atractylodes rhizome, Rhizoma Pinelliae Fermentata 1 ~ 10 Part, 1 ~ 5 part of the shell of areca nut, 5 ~ 10 parts of radix glycyrrhizae.
The preparation method of above-mentioned Camellia nitidissima Jiantang Granule, comprises the following steps：
(1) by proportioning by raw medicinal material Camellia nitidissima, perilla leaf, Poria cocos, dried orange peel, the bark of official magnolia, balloonflower root, ginger, the bighead atractylodes rhizome, Rhizoma Pinelliae Fermentata, big Abdomen skin, radix glycyrrhizae are cleaned, dedusting, dried, and obtain raw medicinal material mixture；
(2) 75% ethanol is added in the mixture obtained into step (1) and carries out refluxing extraction, is extracted 3 times, each 1.5h, is merged Extract solution；
(3) extract solution obtained in step (2) is dried under reduced pressure into dry extract, it is standby is ground into fine powder；
(4) fine powder obtained in step (3) and auxiliary material in mass ratio 1:2 mixing, cross 60 mesh sieves and mix, addition wetting agent is made soft Material；
(5) softwood obtained in step (4) is pelletized, crosses 20 mesh sieves, 60 DEG C of dryings, whole grains, that is, obtain Camellia nitidissima hypoglycemic Granule.
The preparation method of above-mentioned Camellia nitidissima Jiantang Granule, the amount of 75% ethanol is total for raw medicinal material mixture in step (2) 8 times of amount.
The preparation method of above-mentioned Camellia nitidissima Jiantang Granule, the auxiliary material added in step (4) be Icing Sugar and dextrin, Icing Sugar with The mass ratio of dextrin is 1:1.
The preparation method of above-mentioned Camellia nitidissima Jiantang Granule, wetting agent is 80% ethanol in step (4), and the use of wetting agent Amount accounts for the 14% of fine powder quality.
The drug effect of raw material used in the present invention：
Camellia nitidissima：Mildly bitter flavor；It is puckery；It is flat.The effect of with clearing heat and detoxicating, stop dysentery.
Perilla leaf：Acrid flavour, it is warm-natured.Return lung, the spleen channel.With deliver cold dispelling, qi-regulating and in, promoting the circulation of qi is antiabortive, solving toxin of fish and crab Effect.
Poria cocos：It is sweet, light, it is mild-natured.The thoughts of returning home, lung, spleen, kidney channel.With clearing damp and promoting diuresis, invigorating the spleen, the effect of calming heart.
Dried orange peel：It is bitter, pungent, it is warm-natured.Return lung, the spleen channel.With regulating qi-flowing for strengthening spleen, it is eliminating dampness and eliminating phlegm the effect of.
The bark of official magnolia：It is bitter, pungent, it is warm-natured.Returns spleen, stomach, lung, large intestine channel.With eliminating dampness, promoting the circulation of qi, the effect of relievining asthma.
Balloonflower root：It is bitter, pungent, it is mild-natured.Return lung passes through.With facilitaing lung, eliminating the phlegm, relieving sore-throat, the effect of apocenosis.
Ginger：Acrid flavour, slightly warm in nature.Return lung, spleen, stomach.With relieving exterior syndrome and dispelling cold, warming middle energizer to arrest vomiting, warm lung cough-relieving, the work(to detoxify Effect.
The bighead atractylodes rhizome：It is sweet, bitter, it is warm-natured.Returns spleen, stomach.With strengthening the spleen and replenishing qi, eliminate dampness and have diuretic effect, hidroschesis, it is antiabortive the effect of.
Rhizoma Pinelliae Fermentata：Bitter, property are pungent, flat.Return lung, spleen, large intestine channel.With preventing phlegm from forming and stopping coughing, the effect of in the width that helps digestion.
The shell of areca nut：Acrid flavour, slightly warm in nature.Returns spleen, stomach, large intestine, small intestinl channel.With promoting the circulation of qi it is wide in, the effect of line water detumescence.
Radix glycyrrhizae：It is sweet, it is mild-natured.The thoughts of returning home, lung, spleen, stomach.It is all with clearing heat and detoxicating, cough-relieving apophlegmatic, tonifying spleen and stomach, mediation The effect of medicine.
Compared with prior art, the invention has the advantages that：Main ingredient Camellia nitidissima has hypoglycemic used in the present invention Effect, Poria cocos, the shell of areca nut can control the urination situation of diabetic, and perilla leaf and ginger have the effect of removing toxic substances, dried orange peel, The bark of official magnolia, balloonflower root, the bighead atractylodes rhizome, Rhizoma Pinelliae Fermentata have the effect of heat-clearing, then mix the drug effect that radix glycyrrhizae carrys out coordinating the drug actions of a prescription；Granule of the present invention Component is appropriate, reasonable mixture ratio, and have reduces blood glucose effect very well, diabetes is originated with the phase, mid-term, the illness in late period have significantly Curative effect, hypoglycemic effect is preferable, and preparation method is simple, convenient to carry out, suitable for large-scale industrial production.
Embodiment
The present invention is described in further detail with reference to instantiation.
Embodiment 1
A kind of Camellia nitidissima Jiantang Granule, is made up of following raw material：Camellia nitidissima 15g, perilla leaf 6g, Poria cocos 25g, dried orange peel 11g, thickness Plain 5g, balloonflower root 3g, ginger 12g, bighead atractylodes rhizome 6g, Rhizoma Pinelliae Fermentata 3g, shell of areca nut 3g, radix glycyrrhizae 8g.
The preparation method of above-mentioned Camellia nitidissima Jiantang Granule, comprises the following steps：
(1) by proportioning by raw medicinal material Camellia nitidissima, perilla leaf, Poria cocos, dried orange peel, the bark of official magnolia, balloonflower root, ginger, the bighead atractylodes rhizome, Rhizoma Pinelliae Fermentata, big Abdomen skin, radix glycyrrhizae are cleaned, dedusting, dried, and obtain raw medicinal material mixture；
(2) the 75% ethanol progress refluxing extractions that 8 times of addition is measured in the mixture obtained into step (1), extraction 3 times, every time 1.5h, merge extract solution；
(3) extract solution obtained in step (2) is dried under reduced pressure into dry extract, it is standby is ground into fine powder；
(4) fine powder obtained in step (3) and auxiliary material in mass ratio 1:2 mixing, cross 60 mesh sieves and mix, add 80% ethanol system Into softwood；Auxiliary material is Icing Sugar and dextrin in mass ratio 1:1 mixture；The dosage of wetting agent accounts for the 14% of fine powder；
(5) softwood obtained in step (4) is pelletized, crosses 20 mesh sieves, 60 DEG C of dryings, whole grains, that is, obtain Camellia nitidissima hypoglycemic Granule, 10g/ bags.
Embodiment 2
A kind of Camellia nitidissima Jiantang Granule, is made up of following raw material：Camellia nitidissima 20g, perilla leaf 8g, Poria cocos 30g, dried orange peel 13g, thickness Plain 6g, balloonflower root 3g, ginger 13g, bighead atractylodes rhizome 6g, Rhizoma Pinelliae Fermentata 3g, shell of areca nut 3g, radix glycyrrhizae 8g.
The preparation method of above-mentioned Camellia nitidissima Jiantang Granule is the same as embodiment 1.
Embodiment 3
A kind of Camellia nitidissima Jiantang Granule, is made up of following raw material：Camellia nitidissima 30g, perilla leaf 10g, Poria cocos 30g, dried orange peel 15g, Bark of official magnolia 6g, balloonflower root 5g, ginger 13g, bighead atractylodes rhizome 6g, Rhizoma Pinelliae Fermentata 3g, shell of areca nut 3g, radix glycyrrhizae 10g.
The preparation method of above-mentioned Camellia nitidissima Jiantang Granule is the same as embodiment 1.
Zoopery 1
1st, experiment mice 120 is taken, male and female half and half, 130 ~ 150g of body weight is respectively divided into three group 1 ~ 3, every group each 40, every group small Mouse sign is good, and physiological characteristic is basically identical, has comparativity.
2nd, it is real to be dissolved in water progress gavage for the Jiantang Granule prepared respectively using the embodiment of the present invention 1 ~ 3 to four groups of mouse Test, 2 times a day, each 10ml（0.1g/ml）, continuously take 15 days, observed during experiment and record the sign of all mouse Situation.
After experiment terminates, four groups of mouse is showed no death, and 20 mouse are randomly selected in each group and are dissected, It was found that the major organs of mouse are showed no abnormal situation, so the hypoglycemic tablet is nontoxic, can use safely.
Clinical test hypoglycemic condition improvement clinical observation statistics
1. case is chosen：Choose and clinically confirm diabetic 120, average age is 40 ~ 75 years old, wherein male 70, female Property 50, is divided into 1 ~ 3 group of experimental group, every group 40.
2. experimental method：The Jiantang Granule prepared respectively using 1-3 of the embodiment of the present invention to experimental group 1-3 groups, daily Using three times, each 10g（One bag）, it is used continuously 15 days, the blood glucose value observed and record patient improves situation.
3. curative effect judging standard：
(1) effective, blood glucose value is maintained in normal range (NR)；
(2) effectively, blood glucose value significantly decreases, but not up in range of normal value；
(3) invalid, blood glucose value does not decline.
4. experimental data counts：
5. experimental result：As can be seen from the above experimental data, the camellia nitidissima granules agent that prepared by the present invention always has for hypoglycemic Efficiency is 96.7%, therefore camellia nitidissima granules agent of the present invention can be used for diabetic, and has good blood sugar decreasing effect.

Claims (5)

1. a kind of Camellia nitidissima Jiantang Granule, it is characterised in that it is made up of following raw material：10 ~ 30 parts of Camellia nitidissima, purple 1 ~ 10 part of perilla leaf, 15 ~ 30 parts of Poria cocos, 10 ~ 20 parts of dried orange peel, 1 ~ 10 part of the bark of official magnolia, 1 ~ 10 part of balloonflower root, 10 ~ 15 parts of ginger, the bighead atractylodes rhizome 1 ~ 10 Part, 1 ~ 10 part of Rhizoma Pinelliae Fermentata, 1 ~ 5 part of the shell of areca nut, 5 ~ 10 parts of radix glycyrrhizae.
2. the preparation method of Camellia nitidissima Jiantang Granule as claimed in claim 1, it is characterised in that comprise the following steps：
(1) by proportioning by raw medicinal material Camellia nitidissima, perilla leaf, Poria cocos, dried orange peel, the bark of official magnolia, balloonflower root, ginger, the bighead atractylodes rhizome, Rhizoma Pinelliae Fermentata, big Abdomen skin, radix glycyrrhizae are cleaned, dedusting, dried, and obtain raw medicinal material mixture；
(2) 75% ethanol is added in the mixture obtained into step (1) and carries out refluxing extraction, is extracted 3 times, each 1.5h, is merged Extract solution；
(3) extract solution obtained in step (2) is dried under reduced pressure into dry extract, it is standby is ground into fine powder；
(4) fine powder obtained in step (3) and auxiliary material in mass ratio 1:2 mixing, cross 60 mesh sieves and mix, addition wetting agent is made soft Material；
(5) softwood obtained in step (4) is pelletized, crosses 20 mesh sieves, 60 DEG C of dryings, whole grains, that is, obtain Camellia nitidissima hypoglycemic Granule.
3. the preparation method of the Camellia nitidissima Jiantang Granule as described in right 2, it is characterised in that the amount of 75% ethanol in step (2) For 8 times of raw medicinal material amount of the mixture.
4. the preparation method of Camellia nitidissima Jiantang Granule as claimed in claim 2, it is characterised in that added in step (4) Auxiliary material is Icing Sugar and dextrin, and the mass ratio of Icing Sugar and dextrin is 1:1.
5. the preparation method of Camellia nitidissima Jiantang Granule as claimed in claim 1, it is characterised in that wetting agent in step (4) The 14% of fine powder quality is accounted for for the dosage of 80% ethanol, and wetting agent.
CN201711121164.XA 2017-11-14 2017-11-14 A kind of Camellia nitidissima Jiantang Granule and preparation method thereof Pending CN107744586A (en)

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113892533A (en) * 2021-09-28 2022-01-07 亳州中药科技学校 Scented tea particles and preparation method thereof
CN116870115A (en) * 2023-07-04 2023-10-13 四川省中医药科学院中医研究所 Composition with blood sugar reducing effect

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113892533A (en) * 2021-09-28 2022-01-07 亳州中药科技学校 Scented tea particles and preparation method thereof
CN116870115A (en) * 2023-07-04 2023-10-13 四川省中医药科学院中医研究所 Composition with blood sugar reducing effect

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Application publication date: 20180302