CN104435141B - A kind of Chinese medicine composition of the treatment diabetes containing Ramulus euonymi - Google Patents
A kind of Chinese medicine composition of the treatment diabetes containing Ramulus euonymi Download PDFInfo
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Abstract
The invention belongs to pharmaceutical technology field, relate to a kind of Chinese medicine composition, be specifically related to the Chinese medicine composition of a kind for the treatment of diabetes containing Ramulus euonymi.The Chinese medicine composition of the treatment diabetes of the present invention is to be prepared from by the medicinal raw material of following weight proportion: the Radix Astragali 7～25 parts, 6～20 parts of duck wheat stem, aratia 3～10 parts, caulis lonicerae 3～10 parts, mulberries 3～10 parts, Ramulus euonymi 1～5 part, 1～5 part of Radix Glycyrrhizae.The present invention treats the Chinese medicine composition of diabetes, and 7 taste medicinal raw materials have Synergistic function by formula rate combined therapy diabetes, is used for treating diabetes curative effect and significantly and has no side effect patient body.
Description
Technical field
The invention belongs to pharmaceutical technology field, relate to a kind of Chinese medicine composition, be specifically related to a kind of containing Ramulus euonymi
The Chinese medicine composition for the treatment of diabetes.
Background technology
Diabetes are one group of metabolic diseases being characterized with hyperglycaemia, are that China's incidence of disease is high, and harm is serious
One of epidemic disease.Long-standing hyperglycaemia during diabetes, causes various tissue, particularly eye, kidney,
Heart, blood vessel, neural chronic lesion, dysfunction, cause various diabetic complication.According to statistics,
The death rate of diabetic complication is only second to cardiovascular disease, cerebrovascular disease and tumour, occupies the 4th.China's sugar
Urine patient's quantity, close to 40,000,000 people, occupies third place in the world, compared with the 0.7% of the eighties in 20th century,
Increase 5 times.Diabetes can be caused by h and E factor interaction, common sympton have many drinks,
Diuresis, eat more and become thin.Diabetes can cause the infringement of health multisystem；Cause insulin definitely or
Insulin sensitivity is reduced by relative hyposecretion and target tissue cell；Cause protein, fat, water and
A series of metabolic disorder syndrome such as electrolyte, wherein with hyperglycaemia as outstanding feature.Treatment diabetes at present
Medicine a lot, especially Western medicine, but side effect is big, and Chinese patent drug effect is notable not.
Content of the invention
It is an object of the invention to provide the Chinese medicine composition of a kind for the treatment of diabetes containing Ramulus euonymi, this Chinese traditional medicine composition
Thing good effect, little to person side effect.
In order to realize foregoing invention purpose, the invention provides techniques below scheme:
The Chinese medicine composition of a kind for the treatment of diabetes containing Ramulus euonymi, is by the medicinal raw material of following weight proportion
Be prepared from: the Radix Astragali 7～25 parts, 6～20 parts of duck wheat stem, aratia 3～10 parts, caulis lonicerae 3～
10 parts, mulberries 3～10 parts, Ramulus euonymi 1～5 part, 1～5 part of Radix Glycyrrhizae.Described various medicinal raw material is
Meet country or Chinese medicine that provincial standard specifies.
Preferably, in above-mentioned medicinal raw material, part by weight shared by the Radix Astragali is 12～18 parts.It is furthermore preferred that it is yellow
Part by weight shared by stilbene is 15 parts.
Preferably, in above-mentioned medicinal raw material, part by weight shared by duck wheat stem is 9～15 parts.It is furthermore preferred that
Part by weight shared by duck wheat stem is 12 parts.
Preferably, in above-mentioned medicinal raw material, part by weight shared by aratia is 5～7 parts.It is furthermore preferred that
Part by weight shared by aratia is 6 parts.
Preferably, in above-mentioned medicinal raw material, part by weight shared by caulis lonicerae is 5～7 parts.It is furthermore preferred that bear
Part by weight shared by winter rattan is 6 parts.
Preferably, in above-mentioned medicinal raw material, part by weight shared by mulberries is 5～7 parts.It is furthermore preferred that mulberries
Shared part by weight is 6 parts.
Preferably, in above-mentioned medicinal raw material, part by weight shared by Ramulus euonymi is 2～4 parts.It is furthermore preferred that it is terrible
Part by weight shared by fletching is 3 parts.
Preferably, in above-mentioned medicinal raw material, part by weight shared by Radix Glycyrrhizae is 2～4 parts.It is furthermore preferred that Radix Glycyrrhizae
Shared part by weight is 3 parts.
The Chinese medicine composition of the treatment diabetes of the present invention, can extract medicine according to conventional Traditional Chinese medicine extraction method
By the active component of raw material, as added boiling water, or carry by the aqueous solution refluxing extraction of ethanol or ethanol collecting
Take liquid and concentrate；Add pharmaceutically acceptable carrier or/and auxiliary material, as starch, dextrin, microcrystalline cellulose,
Amylum pregelatinisatum, magnesium stearate, superfine silica gel powder, sucrose, sodium carboxymethyl starch, hydroxypropyl methyl cellulose,
Vegetable oil, lecithin, polyethylene glycol, propane diols, ethylparaben etc., make agent suitable in pharmacy
Type, such as granule, tablet, hard shell capsules, oral liquid, soft capsule, dripping pill, water pill etc..
Compared with prior art, beneficial effects of the present invention:
The present invention treats the Chinese medicine composition of diabetes, is inventor based on the morbidity to diabetes for motherland's medical science
The understanding of mechanism, according to oneself clinical experience for many years, first determines a series of to treatment glycosuria from numerous Chinese medicines
Sick effective Chinese medicine, more repeatedly verify through clinic and screen.Wherein, the Radix Astragali, the Radix Astragali sweet temperature rise benefit,
Enter spleen, lung channel；Main with righting gas, holding concurrently can be evil except water；Both be apt to bowl spares gas, risen and lift clear sun, be apt to again tonifying lung gas,
Invigorating qi for consolidating superficies, moreover it is possible to torr sore, inducing diuresis for removing edema.Duck wheat stem, sweet-bitter flavor, property puts down, and returns spleen, stomach, big
Intestines warp；Have that invigorating the spleen row is stagnant, effect of regulating qi-flowing for relieving pain, removing toxicity for detumescence；For epigastric distending pain, indigestion,
Dysentery, pain in waist and lower extremities, traumatic injury, carbuncle are swollen dislikes the diseases such as sore.Aratia, another name japanese aralia bark, tiger sun thorn,
Thorn fossilia dentis mastodi；It for Araliaceae fogfruit east area of the Liao River, coextensive with eastern and southern Liaoning Province wood, is used as medicine with root skin；Taste is sweet, bitter, and property is put down；Have
Stomach invigorating, Li Shui, dispel rheumatism, the effect such as promoting blood circulation and stopping pain；For taste-blindness rate, chronic gastritis,
Hepatitis, diabetes, rheumatic arthritis, the disease such as oedema.Caulis lonicerae, another name honeysuckle, honeysuckle stem, gold and silver
Rattan；Dry stem branch for caprifoliaceae plant honeysuckle；Sweet, cold；Attach to the lung and stomach meridians；Have clearing heat and detoxicating, thin
Effect of wind and removing obstruction in channels；For warm disease heating, toxic-heat and blood stasis, carbuncle swells sore, beriberoid pyretic arthralgia, redness and swelling of joints heat
The diseases such as pain.Mulberries, have another name called mulberry fruit, are the dry fruit ear of moraceae plants mulberry.Sweet, sour, cold；The thoughts of returning home, liver,
Kidney channel；There is enriching yin of enriching blood, effect moisturized of promoting the production of body fluid；For dizziness tinnitus, palpitation and insomnia, poliosis,
Tianjin wound is thirsty, the diseases such as interior heat is quenched one's thirst, blood deficiency and constipation.Ramulus euonymi, another name winged euonymus, ghost arrow (" herbal classic "), god
Arrow (" extensively refined "), air pressure gun woods (" will planted by middle traditional Chinese medicines "), pheasant strip (" will planted by northeast medicine "), halberd (" medicine on four sides
Material ") etc.；The branch of tool fin or aliform adjunct for Celastraceae plant winged euonymus；Hardship, cold；" enter
Meridian of Foot-JUE YIN." there is broken blood, stimulate the menstrual flow, effect of desinsection；For controlling through closing, abdominal mass, postpartum the stagnant stomachache of the stasis of blood,
Abdominal pain due to enterositosis etc..Radix Glycyrrhizae, the sweet property of taste is put down；The thoughts of returning home, lung, spleen, stomach warp.Have and invigorate the spleen and benefit qi, heat-clearing solution
Poison, expelling phlegm and arresting coughing, relieving spasm to stop pain, effect of coordinating the drug actions of a prescription.For weakness of the spleen and the stomach, lassitude hypodynamia, palpitaition
Breathe hard, coughing with a lot of sputum, the anxious pain of gastral cavity abdomen, four limbs contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.On
State 7 taste Chinese herbal medicines by formula rate mixing after, extract the work of medicinal raw material according to conventional Traditional Chinese medicine extraction method
Obtain the Chinese medicine composition of the treatment diabetes of the present invention after property component.Formula rate group pressed by 7 taste medicines therein
After conjunction, treatment diabetes have the function of Synergistic, can significantly reduce blood sugar, serum lipid concentrations, improve blood
Flow and anti-oxidation efficacy, treatment diabetes effect is notable and has no side effect.
Detailed description of the invention
Below in conjunction with test example and detailed description of the invention, the present invention is described in further detail.But should be by
This is interpreted as that the scope of the above-mentioned theme of the present invention is only limitted to below example, all real based on present invention institute
Existing technology belongs to the scope of the present invention.
Embodiment 1
The Chinese medicine composition of the treatment diabetes of the present embodiment, is to be prepared by the medicinal raw material of following weight proportion
Form: Radix Astragali 15g, duck wheat stem 12g, aratia 6g, caulis lonicerae 6g, mulberries 6g, Ramulus euonymi 3g,
Radix Glycyrrhizae 3g.
The extracting method of above-mentioned medicinal raw material: take medicinal raw material by formula rate, adds water pan-fried in medicinal raw material
Boil 2 times, be followed successively by medicinal raw material volume by water volume 10 times and 8 times decocting for 2 times, when decocting for 2 times
Between be followed successively by 1.5 hours and 1 hour, filter after decocting every time and collect filtrate；Merge 2 filtrates,
To the extract of embodiment 1 medicinal raw material, the extract of embodiment 1 medicinal raw material is concentrated into relative density
1.20 (80 DEG C), obtain the extract of embodiment 1.
Add the soluble starch of 2 times of weight of extract in above-mentioned extract, pelletize, be dried, be distributed into
Bag, obtains embodiment 1 and treats the Chinese medicinal composition granules of diabetes.
Embodiment 2
The Chinese medicine composition of the treatment diabetes of the present embodiment, is to be prepared by the medicinal raw material of following weight proportion
Form: Radix Astragali 25g, duck wheat stem 6g, aratia 10g, caulis lonicerae 3g, mulberries 3g, Ramulus euonymi 5g,
Radix Glycyrrhizae 3g.
The extracting method of above-mentioned medicinal raw material is with embodiment 1.
Embodiment 3
The Chinese medicine composition of the treatment diabetes of the present embodiment, is to be prepared by the medicinal raw material of following weight proportion
Form: Radix Astragali 18g, duck wheat stem 13g, aratia 7g, caulis lonicerae 8g, mulberries 5g, Ramulus euonymi 2g,
Radix Glycyrrhizae 2g.
The extracting method of above-mentioned medicinal raw material is with embodiment 1.
Comparative example
The Chinese medicine composition of the treatment diabetes of the present embodiment, is to be prepared by the medicinal raw material of following weight proportion
Form: Radix Astragali 15g, duck wheat stem 12g, aratia 6g, caulis lonicerae 6g, mulberries 6g, Radix Glycyrrhizae 3g.
The extracting method of above-mentioned medicinal raw material is with embodiment 1.
Pharmacodynamics test proves:
In order to confirm the efficacy and saferry of medicine of the present invention, inventor has carried out pharmacodynamics and toxicity test is examined
Examine.The research method and the result of the test that are used are as follows:
1st, test material
(1) medicine and reagent:
The Chinese medicine composition of the present invention prepared according to embodiment 1；
The comparative example Chinese medicine composition prepared according to comparative example；
Alloxan, SIGMA Co. produces；
Glucose estimation kit, is produced by Beijing Chemical Plant；
Phenformin, commercially available.
(2) animal: Kunming mouse, is provided by Sichuan institute of antibiotics Experimental Animal Center.
(3) instrument: VZS-723 spectrophotometer, electronic balance etc..
2nd, test method and result:
(1) impact on alloxan diabetes mouse hyperglycaemia for the medicine of the present invention
(1) hyperglycemia model and packet, are made
Taking body weight 25 ± 1g Male Kunming strain mice 80, water is can't help in fasting.After 3 hours, tail vein injection
Alloxan normal saline solution 85mg/kg (0.5ml/ is only) causes hyperglycemia model, separately by 15 body weight
25 ± 1g Male Kunming strain mice tail vein injection normal saline (0.5ml/ is only), moves as normal control
Thing.After 72 hours, above-mentioned mouse fasting be can't help water 10 hours；Then blood, grape glycosyloxy are taken from its eye socket
Chemical-enzyme method surveys every mouse blood sugar concentration.
From 80 injection alloxan normal saline solutions mouse select blood sugar be higher than 200mg/dL and
Close 60 of blood glucose value, are randomly divided into 4 groups, i.e. model group, medicine group of the present invention, control group 1 and fall
Sugar spirit group, often organizes 15.
(2) it, is administered, survey blood sugar concentration
Five groups of mouse gastric infusion and physiological saline as follows respectively: to medicine group gavage of the present invention this
The Chinese medicine composition of bright embodiment 1 preparation, medication accumulated dose: 7g/kg (raw medicinal herbs)；Phenformin group is filled
Stomach phenformin, medication accumulated dose: 80mg/kg；The Chinese drug-treated group that to control group 1 gavage prepared by comparative example of the present invention
Compound, medication accumulated dose: 7g/kg (raw medicinal herbs)；Physiological saline to solvent amounts such as model group gavage；Raw
The physiological saline of the solvent amounts such as reason salt solution group gavages.
Successive administration 10 days, during administration and the ingesting of the mouse respectively organized of fore-and-aft observing, activity and excretion situation
Situation all without exception occurs.After being administered 1 hour in the 10th day, eye socket takes blood, surveys fasting plasma glucose concentration and (prohibits
Food can't help water 10 hours, and method is with aforementioned).Relatively between control group 1 and model group, between each administration group
Difference, the results are shown in Table 1.
Table 1
Note: in table 1, compare with model group:▲▲▲P ＜ 0.001,▲▲P ＜ 0.05,▲P ＞ 0.05.
Table 1 test result indicate that: mouse mainline alloxan is after 72 hours, mouse hyperglycaemia modeling
Success, its blood sugar concentration is significantly higher than physiological saline group.After medicine group successive administration of the present invention 10 days, little
Mouse blood sugar concentration reduces to 385.2 ± 33.1mg/dL, than the mouse blood sugar concentration of model group
Low about the 61mg/dL of 446.4 ± 42.3mg/dL.And the statistics of medicine group of the present invention is relative to model group
Statistics P ＜ 0.05, there is significant difference, the medicine group of the present invention is to alloxan diabetes
The hypoglycemic result for the treatment of of mouse hyperglycaemia is good；And mouse be administered during and front and back have no adverse reaction, the present invention
The traditional Chinese medicine composition for treating diabetes for the treatment of diabetes little to patient body side effect.
And control group 1 successive administration is after 10 days, mouse blood sugar concentration is 424.3 ± 95.3mg/dL, compares model
Low about the 22mg/dL of mouse blood sugar concentration 446.4 ± 42.3mg/dL of group；Than medicine group Mouse Blood of the present invention
Statistical value 385.2 ± 33.1mg/dL height about 39mg/dL of sugar concentration；And the statistics phase of control group 1
For the statistics P ＞ 0.05 of model group, there was no significant difference.Therefore learn, Chinese drug-treated group prepared by comparative example
The hypoglycemic result for the treatment of difference to alloxan diabetes mouse hyperglycaemia for the compound.
To sum up, the present invention treats the Chinese medicine composition of diabetes, and treatment diabetes curative effect is good, instant effect and right
Health has no side effect, and after 7 taste medicinal raw materials press formula rate combination, has Synergistic function；Lack arbitrarily
Component, the curative effect of traditional Chinese medicine composition for treating diabetes all can substantially reduce, in above-mentioned pharmacodynamics test, right
Result for the treatment of according to group 1 substantially reduces relative to the curative effect of medicine group of the present invention, and the treatment glycosuria of the present invention
Sick traditional Chinese medicine composition for treating diabetes are little to patient body side effect.
Claims (3)
1. the Chinese medicine composition of the treatment diabetes containing Ramulus euonymi, it is characterised in that: it is by following weight proportion
Medicinal raw material make: the Radix Astragali 12～18 parts, 9～15 parts of duck wheat stem, aratia 5～7 parts, honeysuckle
5～7 parts of rattan, mulberries 5～7 parts, Ramulus euonymi 2～4 parts, 2～4 parts of Radix Glycyrrhizae.
2. the Chinese medicine composition for the treatment of diabetes according to claim 1, it is characterised in that: shared by aratia
Part by weight is 6 parts.
3. the Chinese medicine composition for the treatment of diabetes according to claim 1, it is characterised in that: weight shared by Ramulus euonymi
Amount ratio is 3 parts.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1907394A (en) * | 2005-08-03 | 2007-02-07 | 张成琼 | Medicine for treating diabetes foot |
| CN1994123A (en) * | 2006-12-11 | 2007-07-11 | 广东医学院 | Health biscuit series containing astragalus root for diabetic patients and preparation process thereof |
| CN101744869A (en) * | 2008-12-19 | 2010-06-23 | 中国科学院兰州化学物理研究所 | Compound traditional Chinese medicine extract composition for preventing and treating diabetes |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1907394A (en) * | 2005-08-03 | 2007-02-07 | 张成琼 | Medicine for treating diabetes foot |
| CN1994123A (en) * | 2006-12-11 | 2007-07-11 | 广东医学院 | Health biscuit series containing astragalus root for diabetic patients and preparation process thereof |
| CN101744869A (en) * | 2008-12-19 | 2010-06-23 | 中国科学院兰州化学物理研究所 | Compound traditional Chinese medicine extract composition for preventing and treating diabetes |
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