CN103920114B - Traditional Chinese medicinal composition for treating pulmonary fibrosis - Google Patents
Traditional Chinese medicinal composition for treating pulmonary fibrosis Download PDFInfo
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- CN103920114B CN103920114B CN201410138995.8A CN201410138995A CN103920114B CN 103920114 B CN103920114 B CN 103920114B CN 201410138995 A CN201410138995 A CN 201410138995A CN 103920114 B CN103920114 B CN 103920114B
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- traditional chinese
- pulmonary fibrosis
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Abstract
The invention discloses a traditional Chinese medicinal composition for treating pulmonary fibrosis, and belongs to the technical field of a traditional Chinese medicine. The traditional Chinese medicinal composition is characterized by being prepared into a gastrointestinal-delivery dosage form from the following traditional Chinese medicinal raw materials by weight: 15-20g of codonopsis pilosula, 15-20g of fruits of Chinese magnoliavine, 15-20g of trichosanthes kirilowii maxim, 15-20g of radix ophiopogonis, 10-12g of rhizoma pinellinae praeparata, 10-12g of radix trichosanthis, 10-12g of thunberg fritillary bulb, 10-12g of cassia twig, 10-12g of nutgrass galingale rhizome, 6-9g of scutellaria baicalensis, 6-9g of dried ginger and 6-9g of honey-fried liquorice. The traditional Chinese medicinal composition disclosed by the invention can significantly improve such symptoms caused by pulmonary fibrosis as chest distress, shortness of breath, chronic cough and gasp syndrome, and can improve pulmonary functions of patients remarkably after long-term use.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition treating pulmonary fibrosis, belong to technical field of traditional Chinese medicines.
Background technology
Pulmonary fibrosis is one group and is oozed out with interstitial lung diffusivity, infiltrates and the disease as major lesions for the fibrillatable, including special
The property sent out pulmonary fibrosis and Secondary cases pulmonary fibrosis, cardinal symptom is had difficulty in breathing for progressive, ultimately results in respiratory failure and wishes.
Its cause of disease is complicated, and poor prognosis clinically lack effective treatment means, are classified as refractory disease by the World Health Organization.Closely
Nian Lai, Chinese traditional treatment pulmonary fibrosis is increasingly subject to pay attention to, and receives satisfactory effect.
Applicant is retrieved to prior art for Chinese traditional treatment pulmonary fibrosis, is now summarized as follows:
1. retrieved in Chinese patent database with " pulmonary fibrosis " for keyword, the number of patent application being related to has:
200410016139.1、200610020716.3、201310466775.3、200410093218.2、201110162621.6、
200710062958.3、201110162761.3、201210323169.1、200810146820.6、201010531346.6、
200810226292.5、201110244047.9、200910172434.9、200910172430.0、201210046990.3、
201110322037.2、200810103844.3、201110109179.0、200410041132.5.Applicant is to above-mentioned patent
In be related to Chinese medicine preparation and analyzed, do not find the Chinese prescription similar with the present invention.
2. retrieved in Chinese periodical paper database with " pulmonary fibrosis " for keyword.
" Treatment Pulmonary F ibrosis by Chinese Herbs progress " (Zhang Juan, Yan Yongjian " Shandong Traditional Chinese Medicine University's journal " January in 2009
Volume 33 the 1st phase) review the progress of Chinese medicine pulmonary fibrosis in nearly 10 years.
" modern traditional Chinese medicine treats the literature research of idiopathic pulmonary fibrosis " (quiet 2012 Shandong Traditional Chinese Medicine University of State of Zhao are large
Scholar's paper) combine modern statistics method, the angle using from square medicine, frequency has been carried out to the square medicine of idiopathic pulmonary fibrosis
Secondary, frequency analysis.The Chinese medicine frequency of usage being related to is as follows:
Above-mentioned data searching is hereby incorporated as prior art.
Content of the invention
The present invention provides a kind of Chinese medicine composition treating pulmonary fibrosis, pulmonary fibrosis is caused uncomfortable in chest, shortness of breath, chronic cough,
The symptoms such as dyspnea are improved substantially, and long-term taking can be obviously improved Pulmonary Function.
The present invention specifically the technical scheme is that
A kind of Chinese medicine composition treating pulmonary fibrosis, is characterized in that, makes intestines by the Chinese medicine material of following part by weight
The formulation of stomach canal drug administration:
Radix Codonopsis, the fruit of Chinese magnoliavine, Snakegourd Seed, the tuber of dwarf lilyturf each 15-20g
The each 10-12g of rhizoma pinellinae praeparata, root of Chinese trichosanthes, fritillaria thunbergii, cassia twig, rhizoma cyperi；
The each 6-9g of the root of large-flowered skullcap, rhizoma zingiberis, honey-fried licorice root.
Currently preferred formulation is: decoction, mixture, syrup, electuary, capsule.Described formulation is according to prior art
Preparation, wherein also includes necessary auxiliary material.
Adopt the latin name of Chinese medicine material as follows in the present invention:
Root of large-flowered skullcap radix scutellariae, Radix Codonopsis radix codonopsis, rhizoma pinellinae praeparata rhizomapinelliae, sky
Pollen radix trichosanthis, cassia twig ramulus cinnamomi, fruit of Chinese magnoliavine fructus schisandrae
Chinensis, rhizoma zingiberis rhizoma zingiberis, Snakegourd Seed semen trichosanthis, rhizoma cyperi rhizoma
Cyperi, honey-fried licorice root radixglycyrrhizae, fritillaria thunbergii bulbus fritillariae thunbergii, the tuber of dwarf lilyturf
radixophiopogonis.
The nature and flavor of traditional Chinese medicinal components and the return through that adopt in the present invention, function and cure mainly as follows:
The root of large-flowered skullcap
[nature and flavor with return footpath] are bitter, tremble with fear.Return lung, courage, spleen, large intestine, small intestinl channel.
[function with cure mainly] heat-clearing and damp-drying drug, purging intense heat and detonicating, hemostasis, antiabortive.For damp-warm syndrome, heat temperature evil of vomitting uncomfortable in chest, damp and hot ruffian
Full, rush down dysentery, jaundice, cough with lung heat, hyperpyrexia polydipsia, blood-head tells nosebleed, carbuncle sore tumefacting virus, fetal irritability.
Radix Codonopsis
[nature and flavor and return through] is sweet, puts down.Returns spleen, lung channel.
[function with cure mainly] tonifying middle-Jiao and Qi, strengthening spleen and tonifying lung.For spleen and lung weakness, shortness of breath palpitations, anorexia and loose stool, void is breathed with cough
Cough, Heat Diabetes.
Rhizoma pinellinae praeparata
[nature and flavor and return through] is pungent, temperature；Poisonous.Returns spleen, stomach, lung channel.
[function with cure mainly] eliminating dampness and eliminating phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, dissolving lump and resolving mass.For abundant expectoration cough and asthma, phlegm retention anti-dazzle nervous, wind phlegm is dizzy
Dizzy, phlegm and headache, vomiting gastric disorder causing nausea, chest gastral cavity ruffian, globus hysteriocus；Controlling outward carbuncle swells subcutaneous nodule is used in life.Pinellia is used for stopping nausea and vomiting by lowering the adverse flow of QI.
Root of Chinese trichosanthes
[nature and flavor and return through] sweet, slight bitter, is slightly cold.Attach to the lung and stomach meridians.
[function with cure mainly] clearing heat and promoting fluid, detumescence and apocenosis.For pyreticosis polydipsia, lung-heat type cough, Heat Diabetes, sore swells
Poison.
Cassia twig
[nature and flavor and return through] acrid, sweet, warm.The thoughts of returning home, lung, bladder warp.
[function with cure mainly] sweating expelling pathogenic factors from muscles and skin, warming meridian, helps yang transforming qi, flat gas that spins.For anemofrigid cold, gastral cavity abdomen is cold
Bitterly, blood trembles with fear Amenorrhea, joint pain, phlegm and retained fluid, oedema, palpitaition, run quickly globefish.
The fruit of Chinese magnoliavine
[nature and flavor and return through] is sour, sweet, temperature.Return lung, the heart, kidney channel.
[function with cure mainly] restrains astringent or styptic treatment for spontaneous sweating, nourishing generate fluid, kidney calming.Breathe heavily for void of coughing long, emission, the enuresis is urinated
Frequently, endless diarrhea, spontaneous perspiration, night sweat, injury thirst, feeble pulse of losing heart, Heat Diabetes, palpitation and insomnia.
Rhizoma zingiberis
[nature and flavor and return through] is pungent, hot.Returns spleen, stomach, kidney, the heart, lung channel.
[function with cure mainly] rhizoma zingiberis warming spleen and stomach for dispelling cold, Back to Yang Tongmai, eliminating dampness dissolving phlegm.For coldness and pain in the epigastrium, vomiting is had loose bowels, limb is cold
Weak pulse, phlegm and retained fluid is breathed with cough.
Snakegourd Seed
[nature and flavor and return through] is sweet, trembles with fear.Return lung, stomach, large intestine channel.
[function with cure mainly] moistening lung for removing phlegm, laxation defaecation.Stick for cough caused by dryness phlegm, dry constipation of intestines.Rhizoma cyperi honey-fried licorice root
[nature and flavor and return through] is sweet, puts down.The thoughts of returning home, lung, spleen, stomach.
[function with cure mainly] invigorates the spleen and benefits qi, clearing heat and detoxicating, expelling phlegm and arresting coughing, relieving spasm to stop pain, coordinating the drug actions of a prescription.Empty for taste
Weak, lassitude hypodynamia, palpitation, coughing with a lot of sputum, gastral cavity abdomen, four limbs contraction, carbuncle sore tumefacting virus, alleviate drug toxicity, strong.
Fritillaria thunbergii
[nature and flavor and return through] is bitter, trembles with fear.Return lung, the heart channel of Hang-Shaoyin.
[function with cure mainly] heat-clearing dissipating bind, preventing phlegm from forming and stopping coughing, for wind-heat affecting lung, phlegm-fire cough, lung carbuncle, acute mastitis, scrofula, sore
Poison.
The tuber of dwarf lilyturf
[nature and flavor and return through] sweet, slight bitter, is slightly cold.The thoughts of returning home, lung, stomach.
[function with cure mainly] nourishing Yin and promoting production of body fluid, moistening lung clears away heart-fire.For dryness of the lung dry cough.Tuberculosis cough, injury thirst, vexed mistake
Sleep, Heat Diabetes, dry constipation of intestines；Pharyngeal diphtheria.
Beneficial effects of the present invention are expanded on further below by way of clinical observation on the therapeutic effect, concrete case.
First, clinical observation on the therapeutic effect test
1. clinical data
Select 2004～2012 patients 35, wherein man 20, female 15,45～65 years old age, average 54.2 years old.
Patient derives from applicant place hospital.
2 treatments and method
Root of large-flowered skullcap 9g, Radix Codonopsis 15g, rhizoma pinellinae praeparata 12g, root of Chinese trichosanthes 12g, cassia twig 12g, fruit of Chinese magnoliavine 15g, rhizoma zingiberis 6g, Snakegourd Seed
15g, rhizoma cyperi 12g, honey-fried licorice root 6g, fritillaria thunbergii 12g, tuber of dwarf lilyturf 15g.Take the prepared slices of Chinese crude drugs of each raw material, above-mentioned consumption is one consumption,
Decoction is cooked into decocting.
Take two doses daily, noon, evening respectively once, every 5 days are a course for the treatment of.Continuously take two courses for the treatment of.
3. clinical observation is summarized
By clinical observation, 88.5% patient persistently takes medicine after a course for the treatment of, and uncomfortable in chest, shortness of breath, cough, asthma symptom subtract
Gently；97.1% patient symptom after two courses for the treatment of of persistently taking medicine substantially mitigates.
2nd, medical record citing
1. Lee x, man, 60 years old.When medical, pulmonary fibrosis existing half a year is suffered from private prosecution, carrys out chest and extremely feels oppressed within nearly one week, tells white
Viscous phlegm, night asthma is acute, and abnormal sweating is many, and chronic cough is more than.After a course for the treatment of of taking medicine, symptom mitigation, night energy prostration, adhere to taking two treatments
Journey, all symptoms substantially mitigate.
2. high xx, female, 46 years old.During first visit, x radiodiagnosis x be pulmonary fibrosis, private prosecution is breathed with cough incessantly recently, night can not lie flat,
Boudoir is slept less, shortness of breath palpitations, aggravates, abundant expectoration, take Chinese and Western medicine repeatly and do not imitate after activity.Tongue is fat, side print with teeth, floating and tense pulse.Medication two
The individual course for the treatment of, symptom mitigation.
Specific embodiment
Embodiment
Root of large-flowered skullcap 9g, Radix Codonopsis 15g, rhizoma pinellinae praeparata 12g, root of Chinese trichosanthes 12g, cassia twig 12g, fruit of Chinese magnoliavine 15g, rhizoma zingiberis 6g, Snakegourd Seed
15g, rhizoma cyperi 12g, honey-fried licorice root 6g, fritillaria thunbergii 12g, tuber of dwarf lilyturf 15g.Take the prepared slices of Chinese crude drugs of each raw material, above-mentioned consumption is one consumption,
Decoction is cooked into decocting.
Claims (2)
1. a kind of Chinese medicine composition treating pulmonary fibrosis, is characterized in that, makes stomach by the Chinese medicine material of following part by weight
The formulation of canal drug administration:
Radix Codonopsis, the fruit of Chinese magnoliavine, Snakegourd Seed, the tuber of dwarf lilyturf each 15-20g；The each 10-12g of rhizoma pinellinae praeparata, root of Chinese trichosanthes, fritillaria thunbergii, cassia twig, rhizoma cyperi；Yellow
The each 6-9g of a kind of reed mentioned in ancient books, rhizoma zingiberis, honey-fried licorice root.
2. the Chinese medicine composition for the treatment of pulmonary fibrosis according to claim 1, is characterized in that, the agent of described Chinese medicine composition
Type is decoction, mixture, syrup, electuary or capsule.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN201410138995.8A CN103920114B (en) | 2014-03-31 | 2014-03-31 | Traditional Chinese medicinal composition for treating pulmonary fibrosis |
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| CN201410138995.8A CN103920114B (en) | 2014-03-31 | 2014-03-31 | Traditional Chinese medicinal composition for treating pulmonary fibrosis |
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| CN103920114B true CN103920114B (en) | 2017-01-18 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106975007B (en) * | 2016-01-16 | 2021-10-26 | 滨州医学院 | Traditional Chinese medicine composition and application thereof in preparation of medicine for treating pulmonary fibrosis diseases |
| CN108452173B (en) * | 2018-06-01 | 2021-03-23 | 江苏省中医院 | Traditional Chinese medicine compound for treating idiopathic pulmonary fibrosis and preparation method and application thereof |
| CN114931624A (en) * | 2022-06-30 | 2022-08-23 | 王虹 | Fresh medicine formula |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101991832A (en) * | 2010-10-30 | 2011-03-30 | 支开叶 | Medicament for treating idiopathic pulmonary fibrosis and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| AU2002307497A1 (en) * | 2001-04-23 | 2002-11-05 | The Regents Of The University Of California | Methods of using interleukin-7 to modulate physiological processes in mammalian pulmonary fibroblasts |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101991832A (en) * | 2010-10-30 | 2011-03-30 | 支开叶 | Medicament for treating idiopathic pulmonary fibrosis and preparation method thereof |
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Effective date of registration: 20170405 Address after: 154002 Jiamusi City, Heilongjiang province university street, No. 148 Patentee after: Jiamusi University Address before: 154000 First Affiliated Hospital of Jiamusi University, Jiamusi, Heilongjiang Province, No. 348 Patentee before: Li Shumin |
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