CN107441401A - Chinese medicine composition for three high drop and preparation method thereof - Google Patents

Chinese medicine composition for three high drop and preparation method thereof Download PDF

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CN107441401A
CN107441401A CN201710872991.6A CN201710872991A CN107441401A CN 107441401 A CN107441401 A CN 107441401A CN 201710872991 A CN201710872991 A CN 201710872991A CN 107441401 A CN107441401 A CN 107441401A
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blood
seed
chinese medicine
maltodextrin
medicine composition
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魏增强
张瑞祥
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/72—Rhamnaceae (Buckthorn family), e.g. buckthorn, chewstick or umbrella-tree
    • A61K36/725—Ziziphus, e.g. jujube
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/02—Algae
    • A61K36/03—Phaeophycota or phaeophyta (brown algae), e.g. Fucus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/07—Basidiomycota, e.g. Cryptococcus
    • A61K36/076—Poria
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
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    • A61K36/18—Magnoliophyta (angiosperms)
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    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/287—Chrysanthemum, e.g. daisy
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/482—Cassia, e.g. golden shower tree
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484—Glycyrrhiza (licorice)
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/488—Pueraria (kudzu)
    • A—HUMAN NECESSITIES
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/489—Sophora, e.g. necklacepod or mamani
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/734—Crataegus (hawthorn)
    • A—HUMAN NECESSITIES
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
    • A61K36/8994—Coix (Job's tears)
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    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
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    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
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    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization

Abstract

The present invention provides a kind of Chinese medicine composition and preparation method for three high drop, and the Chinese medicine composition is composed of the following components by mass percentage：Spina date seed 7%~9%, nutmeg 3%~5%, coix seed 12%~14%, radix glycyrrhizae 3%~5%, Poria cocos 7%~9%, kelp 7%~9%, the sophora bud 7%~9%, chrysanthemum 4%~6%, the root of kudzu vine 7%~9%, cassia seed 7%~9%, hawthorn 7%~9%, radish seed 5%~7%, fructus cannabis 9%~11%.Will above-mentioned component mix after plus water be boiled into after paste with maltodextrin and potassium sorbate mixing granulation, dry, sterilizing,.Chinese medicine of the present invention has the effect of blood circulation promoting and enriching promoting the circulation of qi, promote intestinal absorption, reducing blood lipid, softening blood vessel, promoting blood circulation and removing blood stasis, clearing heat and cooling blood, dredging the channel, defaecation Li Shui, assist insulin to maintain normal sugar metabolism；Reducing blood lipid, hypotensive and blood sugar decreasing effect are good.

Description

Chinese medicine composition for three high drop and preparation method thereof
Technical field
The invention belongs to the Chinese medicine composition of integration of drinking and medicinal herbs category, and in particular to a kind of Chinese medicine composition for three high drop And preparation method thereof.
Background technology
Three height are high fat of blood, hypertension, the general name of hyperglycaemia.Hypertension mean in the circulatory system blood pressure higher than normal and Speech, is often referred to systemic arterial blood pressure and increases, be a kind of common clinical syndrome；Typically with less than 140/90 millimetres of mercury To be normal, and it is hypertension more than or equal to 140/90 millimetres of mercury.High fat of blood refer to blood cholesterol or triglycerides it is too high or HDL-C is too low, and modern medicine is referred to as dyslipidemia；It is the principal element for causing atherosclerosis, It is the hazards of cardiovascular and cerebrovascular diseases occurrence and development.Hyperglycaemia is that glucose content is higher than normal value in body blood, is body An interior self-existent pathological change, for diseased region in blood, lesion nature is dysglycemia.
Hypertension, hyperglycaemia and hyperlipemia, possible individualism, it is also possible to it is interrelated, such as：Diabetes patient is easy to Hypertension or hyperlipemia are suffered from simultaneously, and high fat of blood is the principal element of artery sclerosis formation and development, artery sclerosis is suffered from Person's blood vessel elasticity difference aggravation blood pressure raises, so the later stage all forms " three high diseases ".1. high fat of blood and hypertension interact： Normal person's endangium be it is smooth smooth, if blood fat increase can gradually deposition is in yellow atheromatous plaque under film in the blood vessels, If do not treated, it ulceration, bleeding, blood vessel stenosis, blood fluidity will gradually weaken, blood fat will be made to increase blood pressure rise； In addition, the permanent accumulation of blood fat can cause vascular sclerosis, weaken vessel wall elasticity, blood pressure rise, here it is high fat of blood with it is high Blood pressure interacts；If patient suffers from high fat of blood and hypertension simultaneously, hyperlipidemia can also make the sensitivity of antihypertensive Property be reduced, so treatment hypertension, hyperlipemia unilaterally to treat incessantly, should coordinate to carry out.2. high fat of blood and hyperglycaemia Interact：Many diabetes patients think that high fat of blood is the complication of diabetes with hyperlipidemia；And blood fat increases Person also easily causes cardiovascular and cerebrovascular complication.There is more than half diabetics to have disorders of lipid metabolism problem；Diabetes trigger blood fat to increase When height is mainly insufficient insulin, internal lipase activity will lower, therefore blood fat easily increases.Another aspect diabetes are simultaneously Also with protein and water, fat, dielectric disorder.If another further aspect diabetes patient motion is few, but overfeeding, will make Internal lipid synthesis increases, and causes blood fat to increase.3. hypertension and diabetes interact：Especially obesity-related hypertension disease People is often accompanied by diabetes, and main cause is：Diabetes easily cause kidney damage, so that blood pressure raises.
Although the medicine for treating high fat of blood, hypertension and hyperglycaemia in the market is a lot, all it is monotherapy, lacks Wholistic therapy is considered, but high fat of blood, hypertension and hyperglycaemia have inner link, and they often interact and led Even, therefore the therapeutic effect of existing medicine is fairly limited.
The content of the invention
It is an object of the invention to provide a kind of Chinese medicine composition for three high drop, using the treatment means of solid decoction of medicinal ingredients, For reducing high fat of blood, hypertension and hyperglycaemia, therapeutic effect is good.
The technical solution adopted in the present invention is,
It is raw materials used composed of the following components by mass percentage for the Chinese medicine composition of three high drop：
Spina date seed 7%~9%, nutmeg 3%~5%, coix seed 12%~14%, radix glycyrrhizae 3%~5%, Poria cocos 7%~ 9%th, kelp 7%~9%, the sophora bud 7%~9%, chrysanthemum 4%~6%, the root of kudzu vine 7%~9%, cassia seed 7%~9%, hawthorn 7%~9%, radish seed 5%~7%, fructus cannabis 9%~11%, the mass percent summation of above each component is 100%.
The above-mentioned preparation method for three high drop Chinese medicine composition, including following operating procedure：
Step 1,
By mass percentage, spina date seed 7%~9%, nutmeg 3%~5%, coix seed 12%~14%, radix glycyrrhizae are weighed 3%~5%, Poria cocos 7%~9%, kelp 7%~9%, the sophora bud 7%~9%, chrysanthemum 4%~6%, the root of kudzu vine 7%~9%, certainly Pine torch 7%~9%, hawthorn 7%~9%, radish seed 5%~7%, fructus cannabis 9%~11%, the quality percentage of above each component It is 100% than summation；
Step 2,
13 taste raw materials in step 1 are added water to cook twice, the water of first time plus 10 times of amounts, decocted 2 hours, are added for the second time The water of 6 times of amounts, decoct 2 hours, merge decocting liquid twice, filtering, filtrate is concentrated into relative density as 1.20~1.40 (60 DEG C) Thick paste；
Step 3,
Maltodextrin and potassium sorbate separately are taken, and maltodextrin and potassium sorbate be crushed into 80 mesh, it is standby；
Step 4,
By mass percentage, thick paste 24%~26.97%, the and of maltodextrin 73%~75.97% that step 2 obtains are weighed Potassium sorbate 0.01%~0.03%, the mass percent summation of above each component is 100%；Thick paste and water are stirred To whitewashing, the weight ratio of thick paste and water is 1:2；
Step 5,
In multifunctional fluidized bed, maltodextrin and potassium sorbate are subjected to material heating premix, obtain mixed material, so Pelletized afterwards toward whitewashing on mixed material, finally dry, cool, discharging, shutdown；
Step 6,
Last whole grain and filling, is produced.
In above-mentioned steps 5, by maltodextrin and potassium sorbate be placed in it is multifunctional fluidized bed in, air quantity is arranged to 15m3/ h~ 25m3/ h, EAT are arranged to 80 DEG C~100 DEG C, heating premix are carried out to material 7~15 minutes, obtain mixed material；In advance After mixed, by adjusting air quantity and EAT so that mixed material temperature reaches 35 DEG C~40 DEG C, then multi-functional fluidisation Bed starts to whitewash, and spouting velocity is arranged to 15rpm~20rpm, and atomizing pressure is 1.50bar~2.0bar, due to thing after whitewashing Material aggravates, and temperature reduces, and adjusts air quantity at any time and keeps material fully to jump, and regulation EAT keeps temperature of charge at any time At 35 DEG C~40 DEG C, whitewashing is closed after the 15min~30min that whitewashes, completes granulation；Multifunctional fluidized bed EAT is set again It is set to 100 DEG C material is dried, regulation air quantity keeps material fully to jump, when the moisture≤2.0% of material, by air intake Temperature is down to 25 DEG C~45 DEG C, the temperature of material is reduced to 25 DEG C~45 DEG C, finally discharging shutdown.
In above-mentioned steps 6, the particle that dry particl that step 5 is obtained is chosen on shaking screen between the mesh of 14 mesh~60 is completed Whole grain, then the dry particl of selection is fitted into bag complete it is filling.
The beneficial effects of the invention are as follows：With blood circulation promoting and enriching promoting the circulation of qi, promote intestinal absorption, reducing blood lipid, softening blood vessel, promoting blood circulation The effect of stagnation resolvation, clearing heat and cooling blood, dredging the channel, defaecation Li Shui, assist insulin maintain normal sugar metabolism；Reducing blood lipid, hypotensive It is good with blood sugar decreasing effect；Whole prescription scientific compatibility, the property of medicine is gentle, integration of drinking and medicinal herbs, human body is had no toxic side effect, and can take for a long time With.
Embodiment
The present invention provides a kind of Chinese medicine composition for three high drop, raw materials used by mass percentage by following components group Into：
Spina date seed 7%~9%, nutmeg 3%~5%, coix seed 12%~14%, radix glycyrrhizae 3%~5%, Poria cocos 7%~ 9%th, kelp 7%~9%, the sophora bud 7%~9%, chrysanthemum 4%~6%, the root of kudzu vine 7%~9%, cassia seed 7%~9%, hawthorn 7%~9%, radish seed 5%~7%, fructus cannabis 9%~11%, the mass percent summation of above each component is 100%.
The pharmacological action of Chinese medicine of the present invention is as follows：
Spina date seed：Nourishing heart tonifying liver, antitoxic heart-soothing and sedative, arrest sweating, promotes the production of body fluid, for restlessness of asrhenia type and insomnia, horrified to much dream, body void hidrosis, Tianjin Wound is thirsty.
Nutmeg：It is pungent, temperature, returns spleen stomach large intestine channel middle benefit gas promoting the circulation of qi, relieving diarrhea with astringents, for deficiency-cold in spleen and stomach, endless diarrhea, gastral cavity abdomen Distending pain, deficiency of food vomiting.
Coix seed：Clearing damp and promoting diuresis, invigorating the spleen to arrest diarrhea, eliminating impediment, apocenosis, detoxicating and resolving a mass, for oedema, tinea pedis, difficult urination, it is good for It is the splenic diarrhea to rush down, arthritis with fixed pain caused by dampness contraction, lung carbuncle, acute appendicitis, cancerous swelling.
Radix glycyrrhizae：It is sweet, put down.Thoughts of returning home lung taste are clearing heat and detoxicating through invigorating the spleen and benefiting qi, and remove phlegm and relieving cough, relieving spasm to stop pain, coordinating the drug actions of a prescription. For weakness of the spleen and the stomach, lassitude hypodynamia, palpitation, coughing with a lot of sputum, gastral cavity abdomen, four limbs contraction, carbuncle sore tumefacting virus, alleviate medicine poison Property is strong.
Poria cocos：Clearing damp and promoting diuresis, invigorating the spleen, calming heart, for oedema oliguria, phlegm retention anti-dazzle nervous, spleen eating less, loose stool diarrhea, the mind Uneasiness, insomnia of palpitating with fear.
Kelp：It is salty, tremble with fear, Return liver stomach kidney channel dissolving phlegm softening and resolving hard mass, inducing diuresis for removing edema, testiclar gall, phlegm and retained fluid oedema.
The sophora bud：Cooling blood and hemostasis, clearing liver-fire, for having blood in stool, hemorrhoid blood, bloody flux, uterine bleeding, spit blood, the hot hot eyes of liver, have a headache dizzy It is dizzy.
Chrysanthemum：Wind heat-clearing is dissipated, flat liver improving eyesight is clearing heat and detoxicating, for anemopyretic cold, dizziness of having a headache, red eye, swell pain, eyes dusk Flower, sore and toxic.
The root of kudzu vine：Expelling pathogenic factors from muscles and skin is brought down a fever, and is promoted the production of body fluid to quench thirst, promoting eruption, and Shengyang Zhixie is clearing and activating the channels and collaterals, relieving alcoholism, for fever caused by exogenous pathogens head Bitterly, stiff nape and back, it is thirsty, quench one's thirst, measles without adequate eruption, hot dysentery, diarrhea, dizziness and headache, hemiplegia, chest impediment and cardialgia, during wine poison is hindered.
Cassia seed：It is sweet, it is bitter, it is salty, it is slightly cold, Return liver large intestine channel heat-clearing improving eyesight, relaxes bowel, it is more for the puckery pain of hot eyes, photophobia Tear, dizziness of having a headache, mesh secretly fail to understand, constipation.
Hawthorn：The sweet tepor returns spleen stomach and liver of acid scattered stasis, changes turbid lipid-loweringing through food digesting stomach fortifying.It is swollen for meat stagnation, gastral cavilty It is full, diarrhea dysentery abdominal pain, extravasated blood Amenorrhea, postpartum stasis, confidant sting, chest impediment and cardialgia, hernia pain, hyperlipidemia.
Radish seed：Help digestion de-swelling, lowering the adverse-rising QI to resolve phlegm, and for retention of food and drink, abdominal distention, constipation, stagnate rush down dysentery, and phlegm is stopped up Breath with cough.
Fructus cannabis：Sweet flat returns spleen stomach large intestine channel relaxes bowel.For blood deficiency and depleted fluid, dry constipation of intestines.
According to《Chinese Pharmacopoeia》And modern pharmacological research, with spina date seed, hawthorn, the root of kudzu vine, cassia seed in side, blood circulation promoting and enriching, Blood-activating and qi-promoting is monarch drug in a prescription；Coix seed, nutmeg, intestinal absorption, reducing blood lipid, softening blood vessel, promotion glycometabolism can be promoted, had The effect for adjusting blood pressure, blood fat, blood glucose is ministerial drug；There is acupuncture-stimulating blood stasis dispersing to act as adjutant for radish seed, Poria cocos, kelp, radix glycyrrhizae, The sophora bud, chrysanthemum, fructus cannabis have the function that clearing heat and cooling blood, defaecation Li Shui are to make medicine.All medicines share, play altogether it is promoting blood circulation and removing blood stasis, clearly Hot cool blood, the work(of defaecation profit water, being finally reached reduces by three high purposes.
Chinese medicine composition of the present invention is by the way of oral, and oral 10 grams every time, 2 times a day, one month is a course for the treatment of.
With reference to specific embodiment, the present invention is described in detail.
Embodiment 1
For the preparation method of three high drop Chinese medicine composition, including following operating procedure：
Step 1,
Weigh spina date seed 7kg, nutmeg 5kg, coix seed 14kg, radix glycyrrhizae 5kg, Poria cocos 7kg, kelp 9kg, sophora bud 9kg, chrysanthemum Flower 4kg, root of kudzu vine 7kg, cassia seed 9kg, hawthorn 8kg, radish seed 5kg, fructus cannabis 11kg；
Step 2,
13 taste raw materials in step 1 are added water to cook twice, the water of first time plus 10 times of amounts, decocted 2 hours, are added for the second time The water of 6 times of amounts, decoct 2 hours, merge decocting liquid twice, filtering, filtrate is concentrated into the thick paste that relative density is 1.35 (60 DEG C)；
Step 3,
Maltodextrin and potassium sorbate separately are taken, and maltodextrin and potassium sorbate be crushed into 80 mesh, it is standby；
Step 4,
Weigh thick paste 20.5kg, maltodextrin 61.5kg and potassium sorbate 20g；Thick paste and water are uniformly mixing to obtain spray The weight ratio of slurry, thick paste and water is 1:2；
Step 5,
By maltodextrin and potassium sorbate be placed in it is multifunctional fluidized bed in, air quantity is arranged to 20m3/ h, EAT are set For 90 DEG C, heating premix is carried out to material 10 minutes, obtain mixed material；After premix, by adjusting air quantity and entering wind-warm syndrome Degree so that mixed material temperature reaches 36 DEG C, and then multifunctional fluidized bed to start to whitewash, spouting velocity is arranged to 17rpm, atomization Pressure is 1.70bar, and because material aggravates after whitewashing, temperature reduces, and adjusts air quantity at any time and keeps material fully to jump, and at any time Regulation EAT makes temperature of charge be maintained at 36 DEG C, closes whitewashing after the 20min that whitewashes, completes granulation；Again by multi-functional fluidisation The EAT of bed is arranged to 100 DEG C material is dried, and regulation air quantity keeps material fully to jump, when material moisture≤ When 2.0%, EAT is down to 25 DEG C, the temperature of material is reduced to 25 DEG C, finally discharging shutdown；
Step 6,
The particle that the dry particl that step 5 is obtained is chosen on shaking screen between the mesh of 14 mesh~60 completes whole grain, then will The dry particl of selection be fitted into bag complete it is filling.
Embodiment 2
For the preparation method of three high drop Chinese medicine composition, including following operating procedure：
Step 1,
Weigh spina date seed 8kg, nutmeg 3kg, coix seed 14kg, radix glycyrrhizae 5kg, Poria cocos 8kg, kelp 9kg, sophora bud 8kg, chrysanthemum Flower 6kg, root of kudzu vine 9kg, cassia seed 9kg, hawthorn 7kg, radish seed 5kg, fructus cannabis 9kg；
Step 2,
13 taste raw materials in step 1 are added water to cook twice, the water of first time plus 10 times of amounts, decocted 2 hours, are added for the second time The water of 6 times of amounts, decoct 2 hours, merge decocting liquid twice, filtering, filtrate is concentrated into the thick paste that relative density is 1.20 (60 DEG C)；
Step 3,
Maltodextrin and potassium sorbate separately are taken, and maltodextrin and potassium sorbate be crushed into 80 mesh, it is standby；
Step 4,
Weigh thick paste 24kg, maltodextrin 75.97kg and potassium sorbate 30g；Thick paste and water are uniformly mixing to obtain whitewashing, The weight of thick paste and water ratio is 1:2；
Step 5,
By maltodextrin and potassium sorbate be placed in it is multifunctional fluidized bed in, air quantity is arranged to 25m3/ h, EAT are set For 80 DEG C, heating premix is carried out to material 7 minutes, obtain mixed material；After premix, by adjusting air quantity and entering wind-warm syndrome Degree so that mixed material temperature reaches 40 DEG C, and then multifunctional fluidized bed to start to whitewash, spouting velocity is arranged to 15rpm, atomization Pressure is 1.50bar, and because material aggravates after whitewashing, temperature reduces, and adjusts air quantity at any time and keeps material fully to jump, and at any time Regulation EAT makes temperature of charge be maintained at 40 DEG C, closes whitewashing after the 15min that whitewashes, completes granulation；Again by multi-functional fluidisation The EAT of bed is arranged to 100 DEG C material is dried, and regulation air quantity keeps material fully to jump, when material moisture≤ When 2.0%, EAT is down to 35 DEG C, the temperature of material is reduced to 35 DEG C, finally discharging shutdown；
Step 6,
The particle that the dry particl that step 5 is obtained is chosen on shaking screen between the mesh of 14 mesh~60 completes whole grain, then will The dry particl of selection be fitted into bag complete it is filling.
Embodiment 3
For the preparation method of three high drop Chinese medicine composition, including following operating procedure：
Step 1,
Weigh spina date seed 9kg, nutmeg 4kg, coix seed 13kg, radix glycyrrhizae 3kg, Poria cocos 9kg, kelp 7kg, sophora bud 7kg, chrysanthemum Flower 6kg, root of kudzu vine 9kg, cassia seed 7kg, hawthorn 8kg, radish seed 7kg, fructus cannabis 11kg；
Step 2,
13 taste raw materials in step 1 are added water to cook twice, the water of first time plus 10 times of amounts, decocted 2 hours, are added for the second time The water of 6 times of amounts, decoct 2 hours, merge decocting liquid twice, filtering, filtrate is concentrated into the thick paste that relative density is 1.30 (60 DEG C)；
Step 3,
Maltodextrin and potassium sorbate separately are taken, and maltodextrin and potassium sorbate be crushed into 80 mesh, it is standby；
Step 4,
Weigh thick paste 26.97kg, maltodextrin 73kg and potassium sorbate 30g；Thick paste and water are uniformly mixing to obtain whitewashing, The weight of thick paste and water ratio is 1:2；
Step 5,
By maltodextrin and potassium sorbate be placed in it is multifunctional fluidized bed in, air quantity is arranged to 15m3/ h, EAT are set For 100 DEG C, heating premix is carried out to material 12 minutes, obtain mixed material；After premix, by adjusting air quantity and entering wind-warm syndrome Degree so that when mixed material temperature reaches 38 DEG C, then multifunctional fluidized bed to start to whitewash, spouting velocity is arranged to 18rpm, mist Change pressure is 2.0bar, and because material aggravates after whitewashing, temperature reduces, and adjusts air quantity at any time and keeps material fully to jump, and with When regulation EAT temperature of charge is maintained at 38 DEG C, close whitewashing after the 30min that whitewashes, complete granulation；Again by multi-functional stream The EAT of change bed is arranged to 100 DEG C and material is dried, and regulation air quantity keeps material fully to jump, when the moisture of material When≤2.0%, EAT is down to 30 DEG C, the temperature of material is reduced to 30 DEG C, finally discharging shutdown；
Step 6,
The particle that the dry particl that step 5 is obtained is chosen on shaking screen between the mesh of 14 mesh~60 completes whole grain, then will The dry particl of selection be fitted into bag complete it is filling.
Embodiment 4
For the preparation method of three high drop Chinese medicine composition, including following operating procedure：
Step 1,
Weigh spina date seed 9kg, nutmeg 3kg, coix seed 12kg, radix glycyrrhizae 4kg, Poria cocos 9kg, kelp 8kg, sophora bud 9kg, chrysanthemum Flower 5kg, root of kudzu vine 8kg, cassia seed 8kg, hawthorn 9kg, radish seed 6kg, fructus cannabis 10kg；
Step 2,
13 taste raw materials in step 1 are added water to cook twice, the water of first time plus 10 times of amounts, decocted 2 hours, are added for the second time The water of 6 times of amounts, decoct 2 hours, merge decocting liquid twice, filtering, filtrate is concentrated into the thick paste that relative density is 1.40 (60 DEG C)；
Step 3,
Maltodextrin and potassium sorbate separately are taken, and maltodextrin and potassium sorbate be crushed into 80 mesh, it is standby；
Step 4,
Weigh thick paste 24.02kg, maltodextrin 75.97kg and potassium sorbate 10g；Thick paste and water are uniformly mixing to obtain spray The weight ratio of slurry, thick paste and water is 1:2；
Step 5,
By maltodextrin and potassium sorbate be placed in it is multifunctional fluidized bed in, air quantity is arranged to 20m3/ h, EAT are set For 95 DEG C, heating premix is carried out to material 15 minutes, obtain mixed material；After premix, by adjusting air quantity and entering wind-warm syndrome Degree so that mixed material temperature reaches 35 DEG C, and then multifunctional fluidized bed to start to whitewash, spouting velocity is arranged to 20rpm, atomization Pressure is 1.70bar, and because material aggravates after whitewashing, temperature reduces, and adjusts air quantity at any time and keeps material fully to jump, and at any time Regulation EAT makes temperature of charge be maintained at 35 DEG C, closes whitewashing after the 25min that whitewashes, completes granulation；Again by multi-functional fluidisation The EAT of bed is arranged to 100 DEG C material is dried, and regulation air quantity keeps material fully to jump, when material moisture≤ When 2.0%, EAT is down to 45 DEG C, the temperature of material is reduced to 45 DEG C, finally discharging shutdown；
Step 6,
The particle that the dry particl that step 5 is obtained is chosen on shaking screen between the mesh of 14 mesh~60 completes whole grain, then will The dry particl of selection be fitted into bag complete it is filling.
Clinical data
1st, case selection：
In order to verify the effect of Chinese medicine composition of the present invention, in December, -2016 in June, 2015, the hyperglycaemia for selecting to make a definite diagnosis, 180 clinical observations of high fat of blood and hyperpietic, age 40-70 year, average age 56.2 years old, the course of disease 1 year~15 years.
Diagnostic criteria：
(1) all cases are hyperglycaemia (2 hours blood glucose >=11.1mmol/ of fasting blood-glucose >=7.0mmol/L or postprandial L), high fat of blood (T-CHOL ＞ 5.72mmol/L and/or triglyceride ＞ 1.7mmol/L) and hypertension (systolic pressure >= 140mmhg and/or diastolic pressure >=90mmhg) patient.
2. Clinical symptoms is：Obesity, dizziness, headache, nose heave dizziness, weak, shortness of breath, uncomfortable in chest, extremity numbness, palpitaition are lost Sleep, dysphoria.
Note：The diabetes that above-mentioned 180 patients are suffered from are II type.
2nd, medicament selection：
Patient takes medicine of the present invention, and 2 times a day, each 10g, warm water delivery service in half an hour after meal, 30 days are a treatment Journey, continuously takes 3 courses for the treatment of, and serious patient increases the amount of discretion.
3rd, result：
In 180 hyperlipemic patients：Effective 92, two indexs of serum total cholesterol and triglycerides are dropped in normal model In enclosing (T-CHOL≤5.20mmol/L, triglycerides≤1.7mmol/L), shortness of breath uncomfortable in chest, extremity numbness, have a dizzy spell, god The symptom of tired power disappears, and without recurrence in half a year；Take a turn for the better 70, two indexs of serum total cholesterol and triglycerides have not With the reduction of degree, clinical symptoms make moderate progress；Invalid 18, index and symptom are without improving and have exacerbation trend；It is total effective Rate is 90%.
The statistical result of blood lipids index is detected before table 1 is taken for Chinese medicine of the present invention and after taking
As it can be seen from table 1 Chinese medicine of the present invention has a significant effect to reducing blood fat.
In 180 hyperpietics：Effective 86, blood pressure stabilization is in normal range (NR), and headache is dizzy, the symptom of palpitaition disappears Lose, and without recurrence in half a year；Take a turn for the better 68, blood pressure has different degrees of reduction, and clinical symptoms change；Invalid 26, refer to Mark and symptom are without improving and have exacerbation trend；Total effective rate is 85.6%.
In 180 hyperglycemic patients：Effective 88, (sky drops in normal range (NR) in fasting blood-glucose and postprandial 2 hours blood glucose Abdomen blood glucose 3.9~6.1mmol/L, postprandial 2 hours blood glucose≤7.8mmol/L), thirst and liking drink, fatigue, the clinical symptoms of diuresis disappear Lose, and without recurrence in half a year；Take a turn for the better 70, blood glucose target has different degrees of reduction, and clinical symptoms make moderate progress；Invalid 22 Example, index and symptom are without improving and have exacerbation trend；Total effective rate is 87.8%.
The statistical result of blood glucose target is detected before table 2 is taken for Chinese medicine of the present invention and after taking
From table 2 it can be seen that Chinese medicine of the present invention has a significant effect to reducing blood glucose.
Case 1
Ma, man, 52 years old, Xi'an Gaoling people from area.Suffer from diabetes 10 years, once in local people's hospital admission, be diagnosed as Type II diabetes, and with hypertension and high fat of blood；Patient master states：Usually little motion, headache, dizziness, recurrent exerbation are more Drink, diuresis, more foods；Through chemical examination：Blood pressure 150/90mmHg, glucose in urine (++), fasting blood-glucose 8.7mmol/L, T-CHOL 6.2mmol/L, triglycerides 2.14mmol/L；After diagnosing：Patient is due to insufficient insulin so that internal lipase activity drop It is low, cause patient's disorders of lipid metabolism to cause high fat of blood, and patient's long-term diabetes cause kidney damage to cause hypertension；Patient It is hypoglycemic usually to take Acarbose, Hypotensor No 0 hypotensive, Effects of Xuezhikang reducing blood lipid, Relapse rate, is not controlled effectively System.Medicine of the present invention is taken after 2 months, subjective symptoms has been alleviated, and continues to take medicine of the present invention after 2 months, check chemical examination As a result, glucose in urine (-), fasting blood-glucose 6.5mmol/L, blood pressure 130/80mmHg, T-CHOL 5.59mmol/L, triglyceride 1.72mmol/L, various malaise symptoms are clearly better, and continue to take 1 month to consolidate the course for the treatment of.
Case 2
Lu, female, 48 years old, Xianyang people from Liquan County.Blood pressure systolic pressure 150mmHg, diastolic pressure 100mmHg, T-CHOL 6.8mmol/L, triglyceride 2.4mmol/L, fasting blood-glucose 7.2mmol/L；Had a dizzy spell from daily morning sense, daily not timing Nervous sense uncomfortable in chest is had, is aggravated when tired, it is powerless to occur right side extremity numbness in this year.Continuously take medicine 3 of the present invention After month, blood pressure systolic pressure 125mmHg, diastolic pressure 87mmHg, T-CHOL 5.3mmol/L, triglyceride 1.75mmol/L is low close Spend lipoprotein cholesterol 3.2mmol/L, HDL-C 1.2mmol/L, fasting blood-glucose 5.8mmol/L, dizzy mesh Dizzy sense disappears；Continue to take medicine of the present invention 1 month, patient's subjective symptoms disappears, and right side limb activity is freely.
Case 3
Chen, man, 56 years old, Yulin City people from Mizhi County.First visit on June 10 in 2016, readme：It is dizzy, headache 3 years, every time Morbidity must distending pain, dare not speech, tinnitus battle array work, dizziness, four limbs are numb, upper limbs more so.Repeatly through western medical treatment, postpone symptom, Soon then recur, the red few tongue of flushed face, tongue, small and wiry pulse, blood pressure 160/100mmHg, T-CHOL 6.5mmol/L, glycerine three Fat 2.6mmol/L, fasting blood-glucose 7.0mmol/L.Doctor trained in Western medicine takes Effects of Xuezhikang and Compound Reserpine, therapeutic effect unobvious, symptom Have no obvious mitigation.Chinese medicine of the present invention is taken after 2 months, headache syndromes are alleviated, but still few dizziness, after add with 2 months, blood pressure 130/90mmHg, T-CHOL 5.7mmol/L, triglyceride 1.8mmol/L, fasting blood-glucose 5.5mmol/L, sense of having a dizzy spell disappear Lose, to consolidate the course for the treatment of, continue to take one month.

Claims (4)

1. the Chinese medicine composition for three high drop, it is characterised in that raw materials used composed of the following components by mass percentage：
Spina date seed 7%~9%, nutmeg 3%~5%, coix seed 12%~14%, radix glycyrrhizae 3%~5%, Poria cocos 7%~9%, Kelp 7%~9%, the sophora bud 7%~9%, chrysanthemum 4%~6%, the root of kudzu vine 7%~9%, cassia seed 7%~9%, hawthorn 7%~ 9%th, radish seed 5%~7%, fructus cannabis 9%~11%, the mass percent summation of above each component is 100%.
2. it is used for the preparation method of three high drop Chinese medicine composition described in a kind of claim 1, it is characterised in that including following operation Step：
Step 1,
By mass percentage, weigh spina date seed 7%~9%, nutmeg 3%~5%, coix seed 12%~14%, radix glycyrrhizae 3%~ 5%th, Poria cocos 7%~9%, kelp 7%~9%, the sophora bud 7%~9%, chrysanthemum 4%~6%, the root of kudzu vine 7%~9%, cassia seed 7%~9%, hawthorn 7%~9%, radish seed 5%~7%, fructus cannabis 9%~11%, the mass percent of above each component are total With for 100%；
Step 2,
13 taste raw materials in step 1 are added water to cook twice, add the water of 10 times of amounts for the first time, are decocted 2 hours, second plus 6 times The water of amount, decoct 2 hours, merge decocting liquid twice, filtering, filtrate is concentrated into relative density as the thick of 1.20~1.40 (60 DEG C) Cream；
Step 3,
Maltodextrin and potassium sorbate separately are taken, and maltodextrin and potassium sorbate be crushed into 80 mesh, it is standby；
Step 4,
By mass percentage, thick paste 24%~26.97%, maltodextrin 73%~75.97% and sorb that step 2 obtains are weighed Sour potassium 0.01%~0.03%, the mass percent summation of above each component is 100%；Thick paste and water are uniformly mixing to obtain spray The weight ratio of slurry, thick paste and water is 1:2；
Step 5,
In multifunctional fluidized bed, maltodextrin and potassium sorbate are subjected to material heating premix, obtain mixed material, it is then past Whitewashing is pelletized on mixed material, is finally dried, is cooled, discharging, shutdown；
Step 6,
Last whole grain and filling, is produced.
3. it is used for the preparation method of three high drop Chinese medicine composition according to claim 2, it is characterised in that：In the step 5, By maltodextrin and potassium sorbate be placed in it is multifunctional fluidized bed in, air quantity is arranged to 15m3/ h~25m3/ h, EAT are arranged to 80 DEG C~100 DEG C, heating premix is carried out to material 7~15 minutes, obtain mixed material；After premix, by adjusting air quantity And EAT so that mixed material temperature reaches 35 DEG C~40 DEG C, and then multifunctional fluidized bed to start to whitewash, spouting velocity is set 15rpm~20rpm is set to, atomizing pressure is 1.50bar~2.0bar, and because material aggravates after whitewashing, temperature reduces, and adjusts at any time Section air quantity keeps material fully to jump, and regulation EAT makes temperature of charge be maintained at 35 DEG C~40 DEG C at any time, and whitewash 15min Whitewashing is closed after~30min, completes granulation；Multifunctional fluidized bed EAT is arranged into 100 DEG C again to do material Dry, regulation air quantity keeps material fully to jump, and when the moisture≤2.0% of material, EAT is down into 25 DEG C~45 DEG C, made The temperature of material is reduced to 25 DEG C~45 DEG C, finally discharging shutdown.
4. it is used for the preparation method of three high drop Chinese medicine composition according to claim 2, it is characterised in that：In the step 6, The particle that the dry particl that step 5 is obtained is chosen on shaking screen between the mesh of 14 mesh~60 completes whole grain, then by the dry of selection Particle be fitted into bag complete it is filling.
CN201710872991.6A 2017-09-25 2017-09-25 Chinese medicine composition for three high drop and preparation method thereof Pending CN107441401A (en)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108310265A (en) * 2018-03-22 2018-07-24 湖南橘色科技有限责任公司 A kind of blood fat-reducing blood pressure-decreasing composition and preparation method thereof
CN110150415A (en) * 2019-06-20 2019-08-23 珠海林尚熙养生茶业有限公司 A kind of three high tea-drinkings and preparation method thereof of tranquilizing the mind defaecation prevention

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CN101912484A (en) * 2010-08-02 2010-12-15 魏青山 Chinese medicinal composition for treating hypertension, hyperlipidemia and hyperglycemia
CN104738744A (en) * 2015-03-05 2015-07-01 广西大学 Blood pressure and blood lipid reduction beverage and preparation method thereof

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Publication number Priority date Publication date Assignee Title
CN101912484A (en) * 2010-08-02 2010-12-15 魏青山 Chinese medicinal composition for treating hypertension, hyperlipidemia and hyperglycemia
CN104738744A (en) * 2015-03-05 2015-07-01 广西大学 Blood pressure and blood lipid reduction beverage and preparation method thereof

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108310265A (en) * 2018-03-22 2018-07-24 湖南橘色科技有限责任公司 A kind of blood fat-reducing blood pressure-decreasing composition and preparation method thereof
CN110150415A (en) * 2019-06-20 2019-08-23 珠海林尚熙养生茶业有限公司 A kind of three high tea-drinkings and preparation method thereof of tranquilizing the mind defaecation prevention

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Application publication date: 20171208