CN107080805A - Chinese medicine composition and preparation method for treating coronary heart disease - Google Patents

Chinese medicine composition and preparation method for treating coronary heart disease Download PDF

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CN107080805A
CN107080805A CN201710219548.9A CN201710219548A CN107080805A CN 107080805 A CN107080805 A CN 107080805A CN 201710219548 A CN201710219548 A CN 201710219548A CN 107080805 A CN107080805 A CN 107080805A
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chinese medicine
heart disease
coronary heart
whitewashing
maltodextrin
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魏增强
董文学
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Abstract

The present invention provides a kind of Chinese medicine composition and preparation method for being used to treat coronary heart disease, and the Chinese medicine composition is composed of the following components by mass percentage：Hawthorn 5%~7%, Longstamen Onion Bulb 3%~5%, cloves 3%~5%, lily 5%~7%, peach kernel 11%~13%, the root of kudzu vine 5%~7%, Semen sesami nigrum 5%~7%, spina date seed 5%~7%, mulberry fruit 5%~7%, dried orange peel 3%~5%, arillus longan 5%~7%, Poria cocos 5%~7%, sea-buckthorn 5%~7%, Radix Angelicae Sinensis 11%~13%, rhizoma imperatae 5%~7%, radix glycyrrhizae 3%~5%.Will above-mentioned component mix after add water be boiled into after paste with maltodextrin and potassium sorbate mixing granulation, dry, sterilizing,.The present invention has promoting blood circulation and removing blood stasis, fat eliminating, the work(of promoting qi circulation and relieving pain, to reach the purpose for the treatment of coronary heart disease；Whole prescription scientific compatibility, the property of medicine is gentle, and human body is had no toxic side effect, can long-term taking.

Description

Chinese medicine composition and preparation method for treating coronary heart disease
Technical field
The invention belongs to the Chinese medicine composition of integration of drinking and medicinal herbs category, and in particular to a kind of Chinese medicine group for being used to treat coronary heart disease Compound and preparation method.
Background technology
Coronary cardiopathy abbreviation coronary heart disease, refers to because lipid-metabolism is abnormal, and the lipid calmness in blood exists On the endarterium of otherwise smooth, in endarterium, some similar athero- lipid material accumulations are referred to as moved into white patch Pulse atherosclerosis lesion.These patches increase gradually causes lumen of artery narrow, blood flow is obstructed, and causes heart ischemia, produces the heart Angina.The two big causes of disease of coronary heart disease are coronary atherosclerosis and coronarospasm, and five big pathogenesis basis are：Hypertension, High fat of blood, hyperglycaemia, advanced age, high body weight, eight big inducements are：Fatigue, heavy meal, catch cold, meet an urgent need, infecting, performing the operation, smoking of indulging in excessive drinking, It is excited.
The method of western medical treatment coronary heart disease is mainly：Antiplatelet therapy, anticoagulant therapy, lipid-loweringing and anti-inflammatory treatment；Anti- blood Platelet medicine is the aggregation or activation by obstructed approach blocking platelet, can effectively prevent the formation of coronary artery thrombosis, often It is aspirin and clopidogrel to have medicine；The key agents of anticoagulant therapy are bivalirudin；The method of lipid-lowering therapy is to improve HDL, reduction low-density lipoprotein, cholesterol and triglyceride, to stablize the lipid spot at coronary artery pathological changes Block, prevents it from rupturing and expanding, or even can cut down Lipid Plaque, and key agents are Statins, fibrates, resinae and nicotinic acid Class.Coronary heart disease needs Long-term taking medicine, somewhat expensive, and doctor trained in Western medicine toxic side effect is larger, and liver kidney is damaged, and can not be from The precipitation again that the rubbish such as vascular lipids are solved on source forms new patch, causes blood vessel restenosis, blocking, and cardiac muscle is supplied The problem of not smooth old disease of blood recurs.
The traditional Chinese medical science thinks, coronary heart disease is chest impediment and cardialgia disease, often because of inadequate natural endowment, will lose the day after tomorrow and supports, and both interact institute for a long time Cause；Inadequate natural endowment is mainly manifested in heart-kidney yang deficiency, or the deficiency of liver-yin and kidney-yin；Lose the day after tomorrow to support and then include emotional stimulation, diet satiety, impression Cold, overstrain and induce, its etiology and pathogenesis mainly has aged debility, improper diet, disorder of emotion, inward invasion of pathogenic cold, kidney qi Empty sorrow, deficiency of kidney-YIN can not then nourish the moon of the five internal organs, can cause the heart-yin in-fighting, and the heart-yin virtual loss, heart-yang deficiency can make qi and blood again Operation is lost freely, and general rule pain hair is this disease, and basic pathogenesis is qi deficiency to blood stasis.The conventional medicine for the treatment of coronary disease with traditional Chinese medicine has " Kang Er Heart capsule and pill " and " compound danshen dripping pills ", the major function of both medicines is enriching yin and nourishing kidney, beneficial blood promoting blood circulation, reducing blood lipid, but is treated Effect is not good.
The content of the invention
It is an object of the invention to provide a kind of Chinese medicine composition for treating coronary heart disease, using the treatment means of solid decoction of medicinal ingredients, For the treatment of coronary heart disease, to overcome the problem of Chinese medicine therapeutic effect of existing treatment coronary heart disease is undesirable.
The technical solution adopted in the present invention is,
Chinese medicine composition for treating coronary heart disease, it is by mass percentage, raw materials used composed of the following components：
Hawthorn 5%~7%, Longstamen Onion Bulb 3%~5%, cloves 3%~5%, lily 5%~7%, peach kernel 11%~13%, Pueraria lobota Root 5%~7%, Semen sesami nigrum 5%~7%, spina date seed 5%~7%, mulberry fruit 5%~7%, dried orange peel 3%~5%, arillus longan 5% ~7%, Poria cocos 5%~7%, sea-buckthorn 5%~7%, Radix Angelicae Sinensis 11%~13%, rhizoma imperatae 5%~7%, radix glycyrrhizae 3%~5%, with The mass percent summation of upper each component is 100%.
A kind of preparation method for being used to treat coronary heart disease Chinese medicine composition, including following operating procedure：
Step 1,
By mass percentage, weigh hawthorn 5%~7%, Longstamen Onion Bulb 3%~5%, cloves 3%~5%, lily 5%~7%, Peach kernel 11%~13%, the root of kudzu vine 5%~7%, Semen sesami nigrum 5%~7%, spina date seed 5%~7%, mulberry fruit 5%~7%, dried orange peel 3%~5%, arillus longan 5%~7%, Poria cocos 5%~7%, sea-buckthorn 5%~7%, Radix Angelicae Sinensis 11%~13%, rhizoma imperatae 5%~ 7%th, radix glycyrrhizae 3%~5%, the mass percent summation of above each component is 100%；
Step 2,
16 taste raw materials in step 1 are added water to cook twice, the water of first time plus 10 times of amounts are decocted 2 hours, are added for the second time The water of 6 times of amounts, is decocted 2 hours, merges decocting liquid twice, filtering, it is 1.20~1.40 (60 DEG C) that filtrate, which is concentrated into relative density, Thick paste；
Step 3,
Separately maltodextrin and potassium sorbate are taken, and maltodextrin and potassium sorbate were crushed into 80 mesh, it is standby；
Step 4,
By mass percentage, thick paste 24%~26.97%, the and of maltodextrin 73%~75.97% that step 1 is obtained are weighed Potassium sorbate 0.01%~0.03%, the mass percent summation of above each component is 100%；Thick paste and water are stirred To whitewashing, the weight ratio of thick paste and water is 1:2；
Step 5,
In multifunctional fluidized bed, maltodextrin and potassium sorbate are subjected to material heating and premixed, mixed material is obtained, so Pelletized afterwards toward whitewashing on mixed material, finally dry, cool, discharging, shutdown；
Step 6,
Last whole grain and filling, is produced.
In above-mentioned steps 5, by maltodextrin and potassium sorbate be placed in it is multifunctional fluidized bed in, air quantity is set to 15m3/ h~ 25m3/ h, EAT is set to 80 DEG C~100 DEG C, heating premix is carried out to material 7~15 minutes, obtains mixed material；In advance It is mixed finish after, by adjusting air quantity and EAT so that mixed material temperature reaches 35 DEG C~40 DEG C, then multi-functional fluidisation Bed starts whitewashing, and spouting velocity is set to 15rpm~20rpm, and atomizing pressure is 1.50bar~2.0bar, due to thing after whitewashing Material is aggravated, temperature reduction, and air quantity is adjusted at any time and keeps material fully to jump, and regulation EAT keeps temperature of charge at any time At 35 DEG C~40 DEG C, whitewashing is closed after whitewashing 15min~30min, granulation is completed；Multifunctional fluidized bed EAT is set again It is set to 100 DEG C material is dried, regulation air quantity keeps material fully to jump, when the moisture≤2.0% of material, by air intake Temperature is down to 25 DEG C~45 DEG C, the temperature of material is reduced to 25 DEG C~45 DEG C, finally discharging shutdown.
In above-mentioned steps 6, the particle that the dry particl that step 5 is obtained is chosen on shaking screen between the mesh of 14 mesh~60 is completed The dry particl of selection, is then fitted into bag and completes filling by whole grain.
The beneficial effects of the invention are as follows：Have promoting blood circulation and removing blood stasis, fat eliminating, the work(of promoting qi circulation and relieving pain, to reach the mesh for the treatment of coronary heart disease 's；Whole prescription scientific compatibility, the property of medicine is gentle, and human body is had no toxic side effect, can long-term taking.
Embodiment
The present invention provides a kind of Chinese medicine composition for being used to treat coronary heart disease, by mass percentage, raw materials used by following Component is constituted：
Hawthorn 5%~7%, Longstamen Onion Bulb 3%~5%, cloves 3%~5%, lily 5%~7%, peach kernel 11%~13%, Pueraria lobota Root 5%~7%, Semen sesami nigrum 5%~7%, spina date seed 5%~7%, mulberry fruit 5%~7%, dried orange peel 3%~5%, arillus longan 5% ~7%, Poria cocos 5%~7%, sea-buckthorn 5%~7%, Radix Angelicae Sinensis 11%~13%, rhizoma imperatae 5%~7%, radix glycyrrhizae 3%~5%, with The mass percent summation of upper each component is 100%.
The pharmacological action of Chinese medicine of the present invention is as follows：
Hawthorn：The sweet tepor returns spleen stomach Liver Channel food digesting stomach fortifying of acid, scattered stasis changes turbid lipid-loweringing；For meat stagnation, gastral cavilty is swollen It is full, diarrhea dysentery abdominal pain, extravasated blood Amenorrhea, postpartum stasis, confidant sting, chest impediment and cardialgia, hernia pain, hyperlipidemia.
Longstamen Onion Bulb：Activate yang and remove abstruction, promoting the circulation of qi causes, for chest impediment and cardialgia, epigastric abdominal fullness distending pain, weight after rush down dysentery.
Cloves：It is pungent, temperature；Returns spleen stomach lung kidney channel middle benefit gas drop is inverse, tonifies the kidney and support yang；For deficiency-cold in spleen and stomach hiccup vomiting, deficiency of food is stopped Rush down, trusted subordinate's crymodynia, impotence due to deficiency of the kidney.
Lily：It is sweet, tremble with fear, thoughts of returning home lung channel Yin nourishing and lung moistening, clearing away the heart fire and tranquillizing, for deficiency of Yin cough caused by dryness, consumptive disease is coughed hemoptysis, dysphoria palpitates with fear, Insomnia and dreamful sleep, it is absent-minded.
Peach kernel：Promoting blood circulation, relaxes bowel, relieving cough and asthma, for amenorrhoea dysmenorrhoea, lung carbuncle acute appendicitis, injury from falling down, and intestinal dryness is just It is secret, cough and asthma.
The root of kudzu vine：Expelling pathogenic factors from muscles and skin is brought down a fever, and is promoted the production of body fluid to quench thirst, promoting eruption, and Shengyang Zhixie is clearing and activating the channels and collaterals, relieving alcoholism, for fever caused by exogenous pathogens head Bitterly, stiff nape and back, it is thirsty, quench one's thirst, measles without adequate eruption, hot dysentery, diarrhea, dizziness and headache, hemiplegia, chest impediment and cardialgia, during wine poison is hindered.
Semen sesami nigrum：Filling liver kidney, benefiting essence-blood, ease constipation is dry, for blood and essence asthenia, dizzy, Hiccough and deaf, poliosis, Post disease alopecia, dry constipation of intestines.
Spina date seed：It is sweet, temperature, thoughts of returning home the spleen channel tonifying heart and spleen, nourishing blood and tranquilization；For insufficiency of vital energy and blood, palpitaition is seized with terror secondary, forgetful to lose Sleep, blood deficiency chlorosis.
Mulberry fruit：Nourishing yin and supplementing blood, fluid dryness, for the deficiency of liver-yin and kidney-yin, dizziness and tinnitus, palpitation and insomnia, poliosis, Tianjin wound Yearningly, Heat Diabetes, dry constipation of intestines.
Dried orange peel：Regulating qi-flowing for strengthening spleen is eliminating dampness and eliminating phlegm；For abdominal fullness and distention, deficiency of food is vomited and diarrhoea, coughing with a lot of sputum.
Arillus longan：It is sweet, temperature, thoughts of returning home the spleen channel tonifying heart and spleen, nourishing blood and tranquilization；For insufficiency of vital energy and blood, palpitaition is seized with terror secondary, forgetful to lose Sleep, blood deficiency chlorosis.
Poria cocos：Clearing damp and promoting diuresis, invigorating the spleen, calming heart, for oedema oliguria, phlegm retention anti-dazzle nervous, spleen eating less, loose stool diarrhea, the mind Uneasiness, insomnia of palpitating with fear.
Sea-buckthorn：It is sour and astringent, temperature, returns spleen stomach lung the heart channel of Hang-Shaoyin reinforcing spleen to promote digestion is relieving cough and reducing sputum, promoting blood circulation and removing blood stasis, for spleen eating less, dyspepsia Stomachache, coughing with a lot of sputum, chest impediment and cardialgia, extravasated blood Amenorrhea, fall flutter the stasis of blood swell.
Radix Angelicae Sinensis：Replenishing and activating blood, menstruction regulating and pain relieving, moistening dryness for relaxing bowels, for blood deficiency chlorosis, dizziness palpitaition, irregular menstruation, dysmenorrhoea is closed Through asthenia cold abdominalgia, arthralgia pain due to rheumatism, injury from falling down, ulcer sore wound, dry constipation of intestines.
Rhizoma imperatae：Cooling blood and hemostasis, reducing fever and causing diuresis is spitted blood for blood-head, hematuria, pyreticosis polydipsia, jaundice with damp-heat pathogen, oedema urine It is few, puckery pain of heat gonorrhea.
Radix glycyrrhizae：It is sweet, put down；Thoughts of returning home lung taste are clearing heat and detoxicating through invigorating the spleen and benefiting qi, and remove phlegm and relieving cough, relieving spasm to stop pain, coordinating the drug actions of a prescription； For weakness of the spleen and the stomach, lassitude hypodynamia, palpitation, coughing with a lot of sputum, gastral cavity abdomen, four limbs contraction, carbuncle sore tumefacting virus alleviate medicine poison Property is strong.
Coronary disease and angina pectoris is blood-stasis internal-depression chest, caused by depression and stagnation of QI, controls suitable promoting blood circulation and removing blood stasis, fat eliminating, promoting qi circulation and relieving pain.Root According to《Chinese Pharmacopoeia》, peach kernel blood-breaking row is stagnant and moisturize in side；Sea-buckthorn promoting blood circulation is to relieve pain；Peach kernel and sea-buckthorn are monarch drug in a prescription altogether.Mountain Short, bristly hair or beard, Longstamen Onion Bulb promoting blood circulation fat eliminating；Cloves pungent-warm dissipates row, Poria cocos promoting diuresis with drugs of tasteless flavour, principal drug assistance promoting blood circulation；Hawthorn, Longstamen Onion Bulb, cloves and Poria cocos is ministerial drug altogether.Arillus longan, lily, Semen sesami nigrum, spina date seed, mulberry fruit, rhizoma imperatae, Radix Angelicae Sinensis, blood-nourishing benefit are cloudy, heat clearing and blood circulation promoting；It is old The wide chest promoting the circulation of qi of skin；The root of kudzu vine is risen up to clear sun；Arillus longan, lily, Semen sesami nigrum, spina date seed, mulberry fruit, rhizoma imperatae, Radix Angelicae Sinensis, dried orange peel, the root of kudzu vine For assistant.Radix glycyrrhizae coordinating the drug actions of a prescription, to make.All medicines share, plays promoting blood circulation and removing blood stasis, fat eliminating, the work(of promoting qi circulation and relieving pain, to reach conditioning heart altogether Purpose.
Chinese medicine composition of the present invention is by the way of oral, oral 10 grams every time, 2 times a day, is within one month a course for the treatment of.
With reference to specific embodiment, the present invention is described in detail.
Embodiment 1
Preparation method for treating coronary heart disease Chinese medicine composition, including following operating procedure：
Step 1,
Hawthorn 5kg, Longstamen Onion Bulb 4kg, cloves 4kg, lily 7kg, peach kernel 12kg, root of kudzu vine 6kg, Semen sesami nigrum 7kg, spina date seed 6kg, Mulberry fruit 5kg, dried orange peel 3kg, arillus longan 7kg, Poria cocos 7kg, sea-buckthorn 5kg, Radix Angelicae Sinensis 11kg, rhizoma imperatae 6kg, radix glycyrrhizae 5kg；
Step 2,
16 taste raw materials in step 1 are added water to cook twice, the water of first time plus 10 times of amounts are decocted 2 hours, are added for the second time The water of 6 times of amounts, is decocted 2 hours, merges decocting liquid twice, filtering, and filtrate is concentrated into the thick paste that relative density is 1.35 (60 DEG C)；
Step 3,
Separately maltodextrin and potassium sorbate are taken, and maltodextrin and potassium sorbate were crushed into 80 mesh, it is standby；
Step 4,
Weigh thick paste 20.5kg, maltodextrin 61.5kg and potassium sorbate 20g；Thick paste and water are uniformly mixing to obtain spray The weight ratio of slurry, thick paste and water is 1:2；
Step 5,
By maltodextrin and potassium sorbate be placed in it is multifunctional fluidized bed in, air quantity is set to 20m3/ h, EAT is set For 90 DEG C, heating premix is carried out to material 10 minutes, obtain mixed material；After premix is finished, by adjusting air quantity and entering wind-warm syndrome Degree so that mixed material temperature reaches 36 DEG C, then multifunctional fluidized bed to start whitewashing, spouting velocity is set to 17rpm, is atomized Pressure is 1.70bar, because material is aggravated after whitewashing, temperature reduction, and air quantity is adjusted at any time and keeps material fully to jump, and at any time Regulation EAT makes temperature of charge close whitewashing after being maintained at 36 DEG C, whitewashing 20min, completes granulation；Again by multi-functional fluidisation The EAT of bed is set to 100 DEG C material is dried, and regulation air quantity keeps material fully to jump, when material moisture≤ When 2.0%, EAT is down to 25 DEG C, the temperature of material is reduced to 25 DEG C, finally discharging shutdown；
Step 6,
The particle that the dry particl that step 5 is obtained is chosen on shaking screen between the mesh of 14 mesh~60 completes whole grain, then will The dry particl of selection, which is fitted into bag, completes filling.
Embodiment 2
Preparation method for treating coronary heart disease Chinese medicine composition, including following operating procedure：
Step 1,
Hawthorn 6kg, Longstamen Onion Bulb 4kg, cloves 3kg, lily 6kg, peach kernel 11kg, root of kudzu vine 6kg, Semen sesami nigrum 5kg, spina date seed 7kg, Mulberry fruit 6kg, dried orange peel 4kg, arillus longan 7kg, Poria cocos 6kg, sea-buckthorn 7kg, Radix Angelicae Sinensis 13kg, rhizoma imperatae 6kg, radix glycyrrhizae 3kg；
Step 2,
16 taste raw materials in step 1 are added water to cook twice, the water of first time plus 10 times of amounts are decocted 2 hours, are added for the second time The water of 6 times of amounts, is decocted 2 hours, merges decocting liquid twice, filtering, and filtrate is concentrated into the thick paste that relative density is 1.20 (60 DEG C)；
Step 3,
Separately maltodextrin and potassium sorbate are taken, and maltodextrin and potassium sorbate were crushed into 80 mesh, it is standby；
Step 4,
Weigh thick paste 24kg, maltodextrin 75.97kg and potassium sorbate 30g；Thick paste and water are uniformly mixing to obtain whitewashing, The weight ratio of thick paste and water is 1:2；
Step 5,
By maltodextrin and potassium sorbate be placed in it is multifunctional fluidized bed in, air quantity is set to 25m3/ h, EAT is set For 80 DEG C, heating premix is carried out to material 7 minutes, obtain mixed material；After premix is finished, by adjusting air quantity and entering wind-warm syndrome Degree so that mixed material temperature reaches 40 DEG C, then multifunctional fluidized bed to start whitewashing, spouting velocity is set to 15rpm, is atomized Pressure is 1.50bar, because material is aggravated after whitewashing, temperature reduction, and air quantity is adjusted at any time and keeps material fully to jump, and at any time Regulation EAT makes temperature of charge close whitewashing after being maintained at 40 DEG C, whitewashing 15min, completes granulation；Again by multi-functional fluidisation The EAT of bed is set to 100 DEG C material is dried, and regulation air quantity keeps material fully to jump, when material moisture≤ When 2.0%, EAT is down to 35 DEG C, the temperature of material is reduced to 35 DEG C, finally discharging shutdown；
Step 6,
The particle that the dry particl that step 5 is obtained is chosen on shaking screen between the mesh of 14 mesh~60 completes whole grain, then will The dry particl of selection, which is fitted into bag, completes filling.
Embodiment 3
Preparation method for treating coronary heart disease Chinese medicine composition, including following operating procedure：
Step 1,
Hawthorn 7kg, Longstamen Onion Bulb 5kg, cloves 4kg, lily 5kg, peach kernel 12kg, root of kudzu vine 5kg, Semen sesami nigrum 6kg, spina date seed 7kg, Mulberry fruit 6kg, dried orange peel 4kg, arillus longan 6kg, Poria cocos 5kg, sea-buckthorn 6kg, Radix Angelicae Sinensis 13kg, rhizoma imperatae 5kg, radix glycyrrhizae 4kg；
Step 2,
16 taste raw materials in step 1 are added water to cook twice, the water of first time plus 10 times of amounts are decocted 2 hours, are added for the second time The water of 6 times of amounts, is decocted 2 hours, merges decocting liquid twice, filtering, and filtrate is concentrated into the thick paste that relative density is 1.30 (60 DEG C)；
Step 3,
Separately maltodextrin and potassium sorbate are taken, and maltodextrin and potassium sorbate were crushed into 80 mesh, it is standby；
Step 4,
Weigh thick paste 26.97kg, maltodextrin 73kg and potassium sorbate 30g；Thick paste and water are uniformly mixing to obtain whitewashing, The weight ratio of thick paste and water is 1:2；
Step 5,
By maltodextrin and potassium sorbate be placed in it is multifunctional fluidized bed in, air quantity is set to 15m3/ h, EAT is set For 100 DEG C, heating premix is carried out to material 12 minutes, obtain mixed material；After premix is finished, by adjusting air quantity and entering wind-warm syndrome Degree so that when mixed material temperature reaches 38 DEG C, then multifunctional fluidized bed to start whitewashing, spouting velocity is set to 18rpm, mist Change pressure is 2.0bar, because material is aggravated after whitewashing, temperature reduction, and air quantity is adjusted at any time and keeps material fully to jump, and with When regulation EAT temperature of charge is maintained at 38 DEG C, close whitewashing after whitewashing 30min, complete granulation；Again by multi-functional stream The EAT of change bed is set to 100 DEG C and material is dried, and regulation air quantity keeps material fully to jump, when the moisture of material When≤2.0%, EAT is down to 30 DEG C, the temperature of material is reduced to 30 DEG C, finally discharging shutdown；
Step 6,
The particle that the dry particl that step 5 is obtained is chosen on shaking screen between the mesh of 14 mesh~60 completes whole grain, then will The dry particl of selection, which is fitted into bag, completes filling.
Embodiment 4
Preparation method for treating coronary heart disease Chinese medicine composition, including following operating procedure：
Step 1,
Hawthorn 5kg, Longstamen Onion Bulb 3kg, cloves 5kg, lily 5kg, peach kernel 13kg, root of kudzu vine 7kg, Semen sesami nigrum 5kg, spina date seed 5kg, Mulberry fruit 7kg, dried orange peel 5kg, arillus longan 5kg, Poria cocos 6kg, sea-buckthorn 5kg, Radix Angelicae Sinensis 12kg, rhizoma imperatae 7kg, radix glycyrrhizae 5kg；
Step 2,
16 taste raw materials in step 1 are added water to cook twice, the water of first time plus 10 times of amounts are decocted 2 hours, are added for the second time The water of 6 times of amounts, is decocted 2 hours, merges decocting liquid twice, filtering, and filtrate is concentrated into the thick paste that relative density is 1.40 (60 DEG C)；
Step 3,
Separately maltodextrin and potassium sorbate are taken, and maltodextrin and potassium sorbate were crushed into 80 mesh, it is standby；
Step 4,
Weigh thick paste 24.02kg, maltodextrin 75.97kg and potassium sorbate 10g；Thick paste and water are uniformly mixing to obtain spray The weight ratio of slurry, thick paste and water is 1:2；
Step 5,
By maltodextrin and potassium sorbate be placed in it is multifunctional fluidized bed in, air quantity is set to 20m3/ h, EAT is set For 95 DEG C, heating premix is carried out to material 15 minutes, obtain mixed material；After premix is finished, by adjusting air quantity and entering wind-warm syndrome Degree so that mixed material temperature reaches 35 DEG C, then multifunctional fluidized bed to start whitewashing, spouting velocity is set to 20rpm, is atomized Pressure is 1.70bar, because material is aggravated after whitewashing, temperature reduction, and air quantity is adjusted at any time and keeps material fully to jump, and at any time Regulation EAT makes temperature of charge close whitewashing after being maintained at 35 DEG C, whitewashing 25min, completes granulation；Again by multi-functional fluidisation The EAT of bed is set to 100 DEG C material is dried, and regulation air quantity keeps material fully to jump, when material moisture≤ When 2.0%, EAT is down to 45 DEG C, the temperature of material is reduced to 45 DEG C, finally discharging shutdown；
Step 6,
The particle that the dry particl that step 5 is obtained is chosen on shaking screen between the mesh of 14 mesh~60 completes whole grain, then will The dry particl of selection, which is fitted into bag, completes filling.
Clinical data：
1st, case selection：
In order to verify the effect of pharmaceutical composition of the present invention, in October, -2016 in January, 2015, the coronary heart disease made a definite diagnosis is selected 108 clinical observations of patient, patient is randomly divided into two groups；Treatment group 56, male 26, women 30, age 35-60 Sui, Average age 47.8 years old, the course of disease 6 months~8 years, average course of disease is 3.62 years；Control group 52, male 28, women 24, Age 36-58 Sui, average age 46.2 years old, the course of disease 6 months~8 years, average course of disease is 3.18 years.The course of disease of two groups of cases, disease Shape light and heavy degree is basically identical, no significant difference, with comparativity.
Case inclusive criteria：The lighter's chest distress, unsmooth breath, severe one suffocating pain over the chest, or even chest pain radiating to the back, Shi Zuoshi Only, break out weekly the Treating Patients of Angina Pectoris of more than 2 times；Palpitation and uneasiness, shortness of breath, burnout lazyness speech, lustreless complexion, dizzy mesh It is dizzy, meet labor more very, purplish tongue, few tongue, thready and hesitant pulse；Electrocardioscopy has ischemic change.
Case exclusion standard：
(1) turn out to be on inspection miocardial infarction and other heart diseases, severe neurological functional disease, Climacteric, Pectoralgia person caused by cervical spondylopathy；
(2) moderate above hypertension, severe cardiopulmonary insufficiency, severe arrhythmia cordis, liver, kidney, hemopoietic system etc. are merged Severe primary disease, mental patient；
(3) severe patient with angina pectoris.
2nd, medicament selection：
Treatment group patient takes medicine of the present invention, and 2 times a day, each 10g, warm water delivery service in half an hour after meal, 30 days For a course for the treatment of, 2 to 5 courses for the treatment of are continuously taken, serious patient increases the amount of discretion.
Control group patient takes Diaoxinxue Kang, and (Chengdu Di Ao pharmaceutical Co. Ltds produce, lot number：Chinese medicines quasi-word 20040102), by specification is taken, and 30 days are course for the treatment of, are continuously taken 2 to 5 months, and serious patient follows the doctor's advice increase at discretion use Amount.
3rd, efficacy determination：
(1) cure：Symptom is wholly absent；Through Electrocardioscopy, reach normal.
(2) it is effective：Symptom disappears or basic disappearance；Through Electrocardioscopy, reach substantially normal.
(3) effectively：Panic attacks number of times, degree and duration have obvious mitigation；Through Electrocardioscopy, the drop of S-T segment It is low, with more than rise 0.05mv after treatment, but not up to normal level, shoal in main lead negative T wave (up to 25% with Upper person)；Or T ripples are changed into upright from flat, chamber or intraventricular block improver；
(4) it is invalid：Clinical symptom and sign and Electrocardioscopy are unchanged.
4th, result：
In the treatment group for taking medicine of the present invention, 16 are cured, effective 23, effective 10, invalid 7, cure rate is 28.57%, total effective rate 87.5%.
10 are cured in control group, effective 18, effective 9, invalid 15, cure rate is 19.23%, total effective rate 71.15%.
Result above shows, the cure rate and total effective rate for the treatment of group are apparently higher than control group.
Case 1
Lee in Xianyang, Shanxi province city, man, 52 years old；Readme：Daily life is asymptomatic, occurs after motion or excessively work Of short duration episode, each pain lasts are less than 5 minutes, and rest is lower or sublingual take pain after nitroglycerin and can disappear；Diagnosis For：Slight labor angina；Take after Chinese medicine of the present invention, daily two doses (one 10g), 2 courses for the treatment of, symptom is clearly better, Continue to take 2 courses for the treatment of, symptom disappears, through Electrocardioscopy, reach normal.
Case 2
50 years old, there is angina pectoris the year before in the Chen of Shaanxi Province Lantian County, female, feels acute for continuation at heart later Strong constriction, pain, continue 5~10 minutes every time, and with symptoms such as low fever, dysphoria, dizziness, expiratory dyspnea；Through Check：Electrocardiogram II, III, avF, V5, V6 ST-Segment move down 1.0~1.5mv；Chinese medicine of the present invention is taken, daily two doses (one 10g), after 3 courses for the treatment of, symptom is clearly better, only even to have slight pectoralgia；Continue to take 2 cycles, symptom disappears, through electrocardiogram Check, reach normal.
Case 3
Shaanxi Province congratulates certain in Weinan City Fuping County, man, 60 years old, toward having history of coronary heart disease 3 years, often takes isosorbide dinitrate or nitric acid Glycerine etc. is treated；There is hypertension history, the inspection ST-T that has an electro-cardiogram is inverted, left ventricular hypertrophy；Daily two doses are taken after this formula After (one 10g), 3 courses for the treatment of, symptom is clearly better, and pectoralgia number of times is significantly reduced, and continues to take 2 courses for the treatment of, symptom disappears, warp Electrocardioscopy, reaches normal.
Case 4
Shaanxi Province Hanzhong City Chenggu County Lee, man, 44 years old, readme：Had difficulty in breathing when doing physical labor within 2015, breath It is very brief, have palpitation, shortness of breath, uncomfortable in chest, there being chest when serious violent burns sample pain；Examination in hospital is coronary heart disease, is controlled by medicine Treat, though take a favorable turn, recurrent exerbation；Come here to go to a doctor, take after Chinese medicine of the present invention, daily two doses (one 10g), 3 courses for the treatment of, Symptom substantially mitigates, and the number of times that symptom occurs is significantly reduced, and continues to take 2 courses for the treatment of, symptom disappears, through Electrocardioscopy, reached To normal.

Claims (4)

1. the Chinese medicine composition for treating coronary heart disease, it is characterised in that by mass percentage, raw materials used by following components group Into：
Hawthorn 5%~7%, Longstamen Onion Bulb 3%~5%, cloves 3%~5%, lily 5%~7%, peach kernel 11%~13%, the root of kudzu vine 5%~7%, Semen sesami nigrum 5%~7%, spina date seed 5%~7%, mulberry fruit 5%~7%, dried orange peel 3%~5%, arillus longan 5%~ 7%th, Poria cocos 5%~7%, sea-buckthorn 5%~7%, Radix Angelicae Sinensis 11%~13%, rhizoma imperatae 5%~7%, radix glycyrrhizae 3%~5%, the above The mass percent summation of each component is 100%.
2. it is used for the preparation method for treating coronary heart disease Chinese medicine composition described in a kind of claim 1, it is characterised in that including following Operating procedure：
Step 1,
By mass percentage, hawthorn 5%~7%, Longstamen Onion Bulb 3%~5%, cloves 3%~5%, lily 5%~7%, peach kernel are weighed 11%~13%, the root of kudzu vine 5%~7%, Semen sesami nigrum 5%~7%, spina date seed 5%~7%, mulberry fruit 5%~7%, dried orange peel 3%~ 5%th, arillus longan 5%~7%, Poria cocos 5%~7%, sea-buckthorn 5%~7%, Radix Angelicae Sinensis 11%~13%, rhizoma imperatae 5%~7%, sweet Grass 3%~5%, the mass percent summation of above each component is 100%；
Step 2,
16 taste raw materials in step 1 are added water to cook twice, the water of 10 times of amounts are added for the first time, are decocted 2 hours, second plus 6 times The water of amount, is decocted 2 hours, merges decocting liquid twice, filtering, it is the thick of 1.20~1.40 (60 DEG C) that filtrate, which is concentrated into relative density, Cream；
Step 3,
Separately maltodextrin and potassium sorbate are taken, and maltodextrin and potassium sorbate were crushed into 80 mesh, it is standby；
Step 4,
By mass percentage, thick paste 24%~26.97%, maltodextrin 73%~75.97% and sorb that step 1 is obtained are weighed Sour potassium 0.01%~0.03%, the mass percent summation of above each component is 100%；Thick paste and water are uniformly mixing to obtain spray The weight ratio of slurry, thick paste and water is 1:2；
Step 5,
In multifunctional fluidized bed, maltodextrin and potassium sorbate are subjected to material heating and premixed, mixed material is obtained, it is then past Whitewashing is pelletized on mixed material, is finally dried, cools, discharges, is shut down；
Step 6,
Last whole grain and filling, is produced.
3. it is used for the preparation method for treating coronary heart disease Chinese medicine composition according to claim 2, it is characterised in that：The step In 5, by maltodextrin and potassium sorbate be placed in it is multifunctional fluidized bed in, air quantity is set to 15m3/ h~25m3/ h, EAT is set 80 DEG C~100 DEG C are set to, heating premix is carried out to material 7~15 minutes, mixed material is obtained；After premix is finished, pass through regulation Air quantity and EAT so that mixed material temperature reaches 35 DEG C~40 DEG C, it is then multifunctional fluidized bed to start whitewashing, whitewashing speed Degree is set to 15rpm~20rpm, and atomizing pressure is 1.50bar~2.0bar, because material is aggravated after whitewashing, temperature reduction, with When regulation air quantity keep material fully to jump, and regulation EAT makes temperature of charge be maintained at 35 DEG C~40 DEG C at any time, whitewashing Whitewashing is closed after 15min~30min, granulation is completed；Multifunctional fluidized bed EAT is set into 100 DEG C again to enter material Row drying, regulation air quantity keeps material fully to jump, and when the moisture≤2.0% of material, EAT is down into 25 DEG C~45 DEG C, the temperature of material is reduced to 25 DEG C~45 DEG C, finally discharging shutdown.
4. it is used for the preparation method for treating coronary heart disease Chinese medicine composition according to claim 2, it is characterised in that：The step In 6, the particle that the dry particl that step 5 is obtained is chosen on shaking screen between the mesh of 14 mesh~60 completes whole grain, then will choose Dry particl be fitted into bag and complete filling.
CN201710219548.9A 2017-04-06 2017-04-06 Chinese medicine composition and preparation method for treating coronary heart disease Pending CN107080805A (en)

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