CN106668494A - Hui nationality traditional Chinese medicine astragalus membranaceus root stomach cancer-dispersing granules and preparation method thereof - Google Patents

Abstract

The invention relates to a formula of Hui nationality traditional Chinese medicine astragalus membranaceus root stomach cancer-dispersing granules and a preparation method thereof. The granules are Chinese herbal medicine with environmental friendlessness as well as high science and technology for treating stomach cancer, especially stomach cancer with difficult operation at a late period due to various reasons; the Hui nationality traditional Chinese medicine astragalus membranaceus root stomach cancer-dispersing granules comprise the raw materials of astragalus membranaceus, radix Codonopsis, bitter herbs root, cortex acanthopanacis, Psoralea corylifolia and polygonatum rhizome according to a certain proportion, and the preparation method comprises the steps of mixing, adding water, decocting, extracting, concentrating, and granulating; and the astragalus membranaceus root stomach cancer-dispersing granules are used for mainly treating digestive system cancers such as stomach cancer, throat cancer, esophagus cancer, cardia cancer, and colorectal cancer. The astragalus membranaceus root stomach cancer-dispersing granules have the characteristics of moderate flavor and dosage, and the selected raw materials can be used for treating cancer through modern medical pharmacology experiments.

Description

Hui ethnic group's Chinese medicine stilbene root cancer of the stomach disappears particle and preparation method thereof

Technical field

Hui ethnic group's Chinese medicine stilbene root cancer of the stomach according to the present invention particle that disappears is a kind of to treat late gastric cancer especially because the green high-tech Chinese herbal medicine of late gastric cancer that cannot be performed the operation of a variety of causes.The invention further relates to the preparation method of the medicine, belongs to traditional Chinese medicine class.

Background technology

According to《China's tumour registration annual report in 2014》Data display, according to China for each person 74 years old life-span calculate, Chinese all one's life suffer from malignant tumour probability be 22%, average minute clock has 6 people to be diagnosed as malignant tumour, and tumour has become a kind of common disease in China.At present the cancer patient of China is about ten thousand people more than 700, and every year with the speed of more than 100 ten thousand people in increase.And the whole world

According to statistics, in the cancer patient of China nearly 8,000,000, have 31.27% for Alimentary System patient, wherein patients with gastric cancer accounts for the 41.83% of Alimentary System patient, almost half.

China is one of incidence gastric cancer rate highest country, and the whole world is annual newly to send out patients with gastric cancer more than 100 ten thousand, and China just account for 42%, and death toll China has accounted for 35%, and the M ＆ M of Chinese cancer of the stomach is world average level more than 2 times！Inherent cause among these, immune factor, helicobacter pylori infections factor are all nothing difficult, and most anxious is then environment and dietary factor ...

The early symptom of cancer of the stomach is not obvious, generally needs time of 2 years or so from incidence gastric cancer to finding tumour, therefore often ignored, once and to standing, most likely reach an advanced stage.

It is operation to control cancer of the stomach the best way at present, postoperative to be also performed to chemotherapy, and chemotherapy not only large side effects, patient suffering is difficult to stand, and success rate is also very low, 1 year life cycle after most Chemotherapy in Patients less than --- certainly this is also relevant with the over-treatment given birth to without skilful doctor.And on the other hand, although some are detected to be cancer of the stomach, because a variety of causes cannot be performed the operation,Can only palliative treatment, expect that miracle comes ...

Cancer of the stomach is at present more refractory disease more, but refractory representative cannot be controlled, and in addition to above-mentioned western medical treatment method, the traditional Chinese medical science also has many effectively treatment methods.The traditional Chinese medical science, according to the whole body feature diagnosis and treatment of patient, goes for various each phase cancer with organic conception.The advantage of Chinese medicine cancer is to be conducive to stablizing the state of an illness, and toxic and side effect is slight, symptom improves more apparent, slows down PD, tumor regression or the longer-term existence of band knurl, and patient is easy to receive and expense is than less expensive.At present doctor trained in Western medicine is also considered as traditional Chinese medicine can contribute to reducing the toxicity of Radiotherapy chemotherapy as the auxiliary treatment of cancer, improve cancer related symptoms, improve life quality, extend life cycle.But exist problem be the traditional Chinese medical science prescription uniformity it is poor, treatment mainly be experience.From in terms of existing proved recipe for cancer, folk prescription, always there is --- majority is more than more than half --- medicine to be all not prove " compatibility " medicine of function for cancer and effect " diagnosis and treatment based on an overall analysis of the illness and the patient's condition " by modern medicine pharmacological evaluation in selected Chinese herbal medicine medicinal material, inventors believe that very improper；And folk prescription, folk prescription cure the disease lean on be test, often stop over the time cured the disease.

The content of the invention

The purpose of the present invention, be aiming at Cancer in China patient assessment be difficult to and in the side's of curing the desease poor consistency, repeatable poor, high level evidence-based medicine EBM be theoretical and the relative shortage of evidence,Thus the situation for waiting deficiency by rule of thumb that is mainly for cancer, propose a kind of new dosage and preparation method, there is provided one kind reduces the incidence of disease of cancer of the stomach from the beginning of prevention, start to slow down its tempo from canceration, the green high-tech Chinese herbal medicine for inducing its atrophy apoptosis is started from tumour.Specifically, the present invention one be particularly suited for use in treatment cancer before larger gastric ulcer in case its canceration, two is the especially big gastric ulcer that can treat the cancer of the stomach initial stage, in case it continues to deteriorate, three are can induce into the cancerous swelling atrophy apoptosis of knurl, with very low cost, fundamentally improve physical function, so as to get well.Its sharpest edges are to greatest extent to induce self apoptosis of cancer cell and differentiation, promote cancerous swelling progressively atrophy.In specific formula, also coordinate diagnosis and treatment based on an overall analysis of the illness and the patient's condition, according to the origin cause of formation of cancer of the stomach because dietary factor makes nutrient disequilibrium cause immunologic hypofunction, because Helicobacter pylori infection causes stomach normal cell to be compromised, apoptosis, gastritis, digestive tract ulcer, lymphoproliferative gastric lymphoma " is taken advantage of a weak point " evil poison positive pressure, flee channels and collaterals visitor the characteristics of internal organs form long product and cause the basic pathology interpretation of the cause, onset and process of an illness such as Metastasis of Gastric Cancer because evil poison being tied in sick protracted blood stasis and being wrapped hemostasis and is taken advantage of a weak point in opponent's defence, with the tonifying speen and tonifying kidney strengthening vital QI to eliminate pathogenic factors method that tonification and purgation in combination, it is empty in healthy tendency to correct, poly- and internal organs imbalance of yin and yang function reduction the deficiency of the solidifying poison of heresy, adjust and improve the immunologic function of body.Simultaneously according to the concrete condition of patient, different formulas, or easypro liver and stomach, drop check pain, or detoxification and removing stasis, clearing heat and nourishing yin, or warming spleen and stomach for dispelling cold, strengthening the spleen and stomach, or strongly invigorating QI and blood are respectively adopted, strengthening spleen, tonifying kidney ... is reachingTonification and purgation in combination, reinforcing and reducing methods and use, the purpose of overall tumor suppression, so as to improve the overall curative effect and late result of curing gastric cancer, a kind of green high-tech Chinese herbal medicine formula and compound method that function for cancer and effect are proved by modern medicine pharmacological evaluation is provided for patients with gastric cancer, with very low or relatively low cost, fundamentally improve physical function, the deterioration of symptom management simultaneously makes the state of an illness gradually take a turn for the better, and finally recovers healthy.Thus also to patient one select different treatment methods or several method to share particularly traditional Chinese and western medicine to combine the leeway of complex treatment application to consider according to the personal state of an illness, economic situation, personal inclination, to obtaining optimum curative effect, survival rate is easily improved --- particularly more than 5 years survival rates.

Technical scheme proposed by the invention is：

Hui ethnic group's Chinese medicine stilbene root cancer of the stomach of the first, described treatment cancer of the stomach disappears particle and preparation method thereof, is by made by following weight proportion raw material：

Radix Astragali 9g, common sowthistle root 30g, Radix Rabdosiae glaucocalycis 30g, Radix Codonopsis 9g,

Cortex acanthopanacis 9g, Psoralea corylifolia 9g, sealwort 9g, coptis 3g,

The lobe of purple garlic 3, honey 50g,

This side is substantially square for one decoction on the one.In practical application, also theoretical " dialectical compatibility " medicine of the 1-3 taste traditional Chinese medical science " harmony between man and nature, dialectical treatmert " can be increased according to the physique of patient and conditions.

In view of with this, basic side's decoction decoction of medicinal ingredients amount is big, taste is not good enough, patient is difficult to drink, therefore must be prepared using special process.

2nd, it is by the preparation method that above-mentioned each raw material makes Chinese medicinal granule of the present invention：

A, extract preparation

（1）, extract

A, for the first time extraction：By the weight of said herbal medicine in addition to Radix Codonopsis, the coptis, purple garlic, honey, all amplify 10 times, after clean water, it is placed in BT-2 stainless steels to extract in kettle, plus after 7-9 times of running water, is heated to 100 DEG C of constant temperature and extracts 1 hour or so, extraction fluid, pressure filtration, filtrate is standby.

B, second extraction：Add in kettle the 5-7 times of running water measured toward extracting, be heated to 100 DEG C of constant temperature and extract or so half an hour, extraction fluid, pressure filtration, filtrate is standby.

C, third time are extracted：Add in kettle the 3-5 times of running water measured toward extracting, be heated to 100 DEG C of constant temperature and extract 20 minutes or so, extraction fluid, pressure filtration, filtrate is standby.

（2）, concentration

The extract of three times is merged, is placed in B-500 type triple effect vacuum high energy evaporation concentrators, reduced pressure (negative 200mmHg), be heated to 80 DEG C, be concentrated into relative density 1.10～1.20, it is standby.

（3）, powder processed

First 10 times of sections of the lobe of purple garlic 3 amplification are dried or dried in the shade, then Radix Codonopsis 9g, coptis 3g are respectively amplified 10 times, together crushing is end, crosses 80 mesh sieves, standby.

（4）, dispensing

In 300,000 grades of dust proof workshops, medicinal powder is put in mixer together with aforementioned concentrate and honey 50g and is sufficiently mixed, stir.

(5), drying, crushing

The spice being well mixed is placed in into 60-70 DEG C of baking 4-5 hour in baking oven, is then crushed, cross 100 mesh sieves.

(6), granulate

The spice being well mixed is inserted in comminutor and is granulated.

(7), whole grain

The particle for making is carried out into whole grain, 35 mesh sieves are crossed.

(8), it is dried

Whole good particle is inserted in heat circulation drying oven, aeration-drying is to moisture ＜ 8% at 80 DEG C.

B, packaging

Particle is fitted into vinyon pouch, every bag of 8-10g, then the pouch mounted box for installing, vanning, sterilizing (are adopted into 60Co irradiation, irradiation dose is 8kGy）.

C, warehouse-in

Irradiated finished product is put in storage by the principle of first in first out.

Routine instructions of taking of the invention：Above-mentioned particle three times a day, 1 bag every time, on an empty stomach (taking half an hour after can not drink water in a large number, in order to avoid water down liquid).The pungent grade food larger to gastrointestinal irritation is not eaten during medication.This medicine is a course for the treatment of in three months, typically takes two to three courses for the treatment of, at most takes four courses for the treatment of.

The effect of each raw material of the present invention：

The Radix Astragali,The Radix Astragali is sweet, tepor.Returns spleen, lung channel.Tonifying spleen lung qi, yang invigorating, benefit defends solid table, diuresis, promoting pus discharge and tissue regeneration.The Radix Astragali is the dry root of legume astragalus mongolicus Astragalus membranacus.Containing amino acid, mucilaginous substance, carbohydrate, bitter principle, choline glycine betaine folic acid, kumatakenin, cupreol（, astragalus polyose etc..It is allCancerPatient is white because of spleen-lung Qi deficiency caused complexion white light, lassitude, receives few loose stool, and hematemesis hematochezia, cough and asthma shortness of breath, abundant expectoration is dilute white, deficiency of QI with disinclination to talk, weak spontaneous perspiration, palpitation and insomnia, fever due to deficiency of vital energy, and edema oliguria etc. can use it.The Radix Astragali can strengthen the phagocytic function of reticuloendothelial system, have facilitation to interferon system, have completeness Immunonormalizing action to cancer patient lymphocytes' function, have fabulous curative effect to precancerous lesion gastric ulcer.

Common sowthistle root,Nature and flavorEffect：Bitter, it is mild-natured.A surname's lung, cold dispelling, eliminating the phlegm apocenosis.It is clinicalUsing：Suitable for lung cancer, bottleneck throat tumour etc..Additionally, be further adapted for that diseases caused by external factors are coughed, expectoration is not well, abscess of throat, pectoralgia, abdominal distension uncomfortable in chest, bronchitis, lung abscess, pleurisy, antiulcer etc..

Radix Rabdosiae glaucocalycis,Nature and flavor are sweet, bitter, cool in nature.Indication:It is clearing heat and detoxicating, stasis-dispelling and pain-killing.Main venomous snake bite, sore furuncle poison, muscles and bones is ached, traumatic injury, burn and scald, invigorating the spleen, promoting blood circulation, controls gastritis, and hepatitis is from the beginning of, cold, fever, Amenorrhea, mastitis, arthralgia.Japan's plectranthin of proposition from Rabdosia amethystoides has antitumor action.

Radix Codonopsis,Effect and effect：" tonifying middle-Jiao and Qi, promotes the production of body fluid, invigorating the spleen, and taste, relieving thirst and restlessness." traditional Chinese medical science thinks Radix Codonopsis flat property and sweet taste, returns spleen, lung channel, the effect of have tonifying middle-Jiao and Qi, strengthening spleen and tonifying lung, can be used for the diseases such as spleen and lung weakness, shortness of breath palpitations, anorexia and loose stool, virtual asthma cough, Heat Diabetes.And newest scientific research discovery, the various nutriments contained in Radix Codonopsis, the body immunity to people, blood vessel, and other organs are helpful.Radix Codonopsis can promote blood in human body in liquid to circulate, while also hematopoiesis regeneration, promotes the effect of red blood cell growth.So as to effectively help people to strengthen body immunity, fitness is improved.Radix Codonopsis has good opsonic action to the digestive system of people.Not only when pathology has occurred in the digestive system of people, disease can be treated using Radix Codonopsis, such as can be nursed one's health by taking Radix Codonopsis decoction when the gastroxia of people, and, usually some Radix Codonopsis just can in advance be taken when, to prevent the disease of digestive system, and the health for promoting digestive system.Because Radix Codonopsis also has certain opsonic action to the immune system of people, therefore some Radix Codonopsis products are eaten, the immunocompetence that can make the person rises, and reduces the incidence of human body diseases.Except, Radix Codonopsis also adjusts cardio-cerebrovascular function, promotes the effect of cardio-cerebrovascular health;Particularly there is hematopoiesis, blood pressure, the effect of reducing blood pressure etc. is adjusted.

Cortex acanthopanacis,Meridian distribution of property and flavor：Pungent, hardship, temperature.People's liver and kidney channel.Effect：Wines used as antirheumatic, strengthens the bone, blood circulation and promoting silt.Control wind-cold-dampness arthralgia, muscles and bones contraction urgency, pain in the back, impotence, flaccidity of lower limbs, children's retardation of walking, oedema, tinea pedis, sore subcutaneous ulcer pyogenic infections, bruise internal lesion caused by overexertion.Effect：This product is warm in nature, the warm promoting blood circulation of energy, there is the work(of promoting blood circulation, for exogenous injury or traumatic injury, there is the stagnant effect of promoting blood circulation, logical solidifyingization, has tonic effect again, to promote early healing.Bushen Yizhi; anti-inflammatory; calm, analgesia, it is antifatigue, strengthen macrophage inducement interferon; T cell, NK cells, K cells, the effect of macrophage killing tumor cell can be strengthened; increasing leukocyte, can be obviously promoted the formation of myeloid lineage progenitor population, there is significantly protection and leucocyte rising effect to the bone marrow suppression that chemotherapy radiotherapy causes; removing toxic substances, also with antitumor action.

Psoralea corylifolia,Taste is pungent；It is bitter；It is warm in nature, kidney；Pericardium；Spleen；Stomach；Lung channel.Indication：Tonify the kidney and support yang；Gas of receiving is relievingd asthma；It is warming spleen and stopping diarrha.The main insufficiency of the kidney yang；Below element deficiency and cold；Waist and knee crymodynia；Impotence and seminal emission；Frequent micturition；The enuresis；The failure of the kidney in receiving air；Void is breathed heavily incessantly；Speen-kidney dificiency；Stool chronic diarrhea；Antitumor action.

Sealwort,For the dry rhizome of liliaceous plant P. kingianum, sealwort or David's-harp.Nature and flavor：It is sweet；It is flat.Return through：The spleen channel；Lung channel；Kidney channel.Effect：Yin nourishing and lung moistening；Invigorate the spleen and benefit qi, Zishen fill fine.There is Yin nourishing and lung moistening；Invigorate the spleen and benefit qi, effect of Zishen fill fine.Often match somebody with somebody ganmai dazao decoction, children's hyperkinetic syndrome, neurosis are controlled in the soft liver nourishing heart of Chinese herbaceous peony.With supplementing qi and nourishing yins such as the Radix Astragali, oyster, the coptiss, purging intense heat is purged heat, and controls hyperthyroidism.With hawthorn, matrimony vine, the fruit of glossy privet, the red sage root is controlled in metabolism and disease.And prevent and treat artery sclerosis, anti-aging.Cure mainly：Deficiency of Yin labor is coughed；Xeropulmonary cough；It is insufficiency of the spleen weak；Few dry of food；Quench one's thirst；Deficiency of the kidney soreness and weakness of waist and knees；Impotence and seminal emission；Tinnitus mesh is dark；Poliosis；Body void is won thin；Wind favus disease.Effect：Sealwort has hypotensive, hypoglycemic, reducing blood lipid, and atherosclerosis, the effect such as anti-aging and antibacterial, Siberian solomonseal rhizome polysaccharide has Immunestimulatory effect.For the lung-dryness syndrome due to yin deficiency, the few phlegm of dry cough, and the labor of lung-kidney deficiency coughs chronic cough etc..For weakness of the spleen and the stomach.Both tonifying spleen-yin, and beneficial temper, obtain dizzy for deficiency of kidney essence, soreness and weakness of waist and knees, poliosis and quench one's thirst.

The coptis,Nature and flavorEffect：It is bitter, cold in nature.Heat-clearing and damp-drying drug, purging intense heat and detonicating.It is clinicalUsing：Suitable for various arsine knurls, such as liver, courage tumour, tongue cancer, lip cancer, the cancer of the esophagus,Cancer of the stomach, carcinoma of urinary bladder etc..Additionally, apply also for unconsciousness due to high fever, haematemesis, bleeding from five sense organs or subcutaneous tissue, furuncle swelling toxin, the disease such as wet sore itch, acute conjunctivitis, aphtha, bacillary dysentery, acute bowel helmet are scorching, heat contains vexed, feeling of fullness, quenches one's thirst, burn.

Honey,Effect of honey and effect：1. the good merchantable brand of cardiovascular patient,HoneyThe composition of blood can be improved, promote heart and brain and vascular function, therefore Jing informal dresses very good for cardiovascular patient；2. protect liver, honey to have protective effect to liver, liver cell regeneration can be promoted, the formation to fatty liver has certain inhibitory action；3. build up resistance, edible honey can regain one's strength of body rapidly, dispelling fatigue builds up one's resistance to disease；4. sterilized, honey also has sterilized effect, Jing often to eat honey, not only without prejudice to tooth, moreover it is possible to play a part of sterilizing in oral cavity, honey can treat the skin damage of moderate, particularly scald, when honey is regarded into skin wound dressing, bacterium cannot grow；5. promote sleep, the people of the insomnia oral 1 soupspoon honey (in 1 glass of warm water of addition) before sleep daily to help fall asleep as early as possible；6. promote gastrointestinal peristalsis, honey to have adjustment effect to gastrointestinal function, gastric acid secretion can be made normal.Zoopery confirms that honey plays the role of to strengthen enterocinesia, can significantly shorten defecation time.

The effect of the present invention：

Cure mainly：Cancer of the stomach, especially because a variety of causes cannot carry out the late gastric cancer of Surgery for Gastric Carcinoma, with very low cost, fundamentally improves physical function, and control tumour continues to overgrow and makes it that final disappearance is gradually reduced, so as to recover healthy.

It is simultaneous to control：The cancer in digestive system such as throat cancer, the cancer of the esophagus, cardiac cancer, pylorus cancer, colorectal cancer.

Our the characteristics of is：

1st, flavour of a drug are more, and dosage is moderate, do not waste.

2nd, selected flavour of a drug are mostly that proved by modern medicine pharmacological evaluation can be for cancer, and existing proved recipe for cancer, then always there are medicines more than half to be all not proved function for cancer and effect by modern medicine pharmacological evaluation in folk prescription.

3rd, for focus, arrow arrow punching, i.e., selected flavour of a drug all especially grow tender of and hit the bull's eye, and As the medicine took effect, the symptoms lessened.As long as rather than it is for cancer, just jump on the bandwagon, being as a result that " dragon " is more bad on the contrary harnesses the river.

4th, as much as possible " neutralisation ", i.e., selected flavour of a drug generally keep " neutrality ", do not tremble with fear not dry, not hot not cool.Patient can be thus set to suffer less within the cycle of whole medication, pull the devil by the tail less.And if really there is the situation of " getting angry " or " under let out ", then can be directed to concrete individual concrete condition completely, add a bit " stopping leak ", the medicine of " fall fire " dialectically temporarily and specifically solve.Rather than imagine at the very start patient may on tell or drop, and some unnecessary medicines are added to prescription, patient is all taken always during very long very long medication, ultimately cause adverse consequences.

Specific embodiment：Radix Astragali 9g, common sowthistle root 30g, Radix Rabdosiae glaucocalycis 30g, cortex acanthopanacis 9g, Psoralea corylifolia 9g, sealwort 11g are respectively amplified into 10 times, after clean water, it is placed in BT-2 stainless steels to extract in kettle, plus after 7-9 times of running water, it is heated to 100 DEG C of constant temperature to extract 1 hour or so, extraction fluid, pressure filtration, filtrate is standby.Extract for second：Add in kettle the 5-7 times of running water measured toward extracting, be heated to 100 DEG C of constant temperature and extract or so half an hour, extraction fluid, pressure filtration, filtrate is standby.Third time is extracted：Add in kettle the 3-5 times of running water measured toward extracting, be heated to 100 DEG C of constant temperature and extract 20 minutes or so, extraction fluid, pressure filtration, filtrate is standby.Concentration：The extract of three times is merged, is placed in B-500 type triple effect vacuum high energy evaporation concentrators, reduced pressure (negative 200mmHg), be heated to 80 DEG C, be concentrated into relative density 1.10～1.20, it is standby.Powder processed：First 10 times of sections of the lobe of purple garlic 3 amplification are dried or dried in the shade, then Radix Codonopsis 9g, coptis 3g are respectively amplified 10 times, together crushing is end, crosses 80 mesh sieves, standby.Dispensing：In 300,000 grades of dust proof workshops, medicinal powder is put in mixer together with aforementioned concentrate and 50g honey and is sufficiently mixed, stir.Drying, crushing：The spice being well mixed is placed in into 60-70 DEG C of baking 4-5 hour in baking oven, is then crushed, cross 100 mesh sieves.Granulation：The spice being well mixed is inserted in comminutor and is granulated.Whole grain：The particle for making is carried out into whole grain, 35 mesh sieves are crossed.It is dried：Whole good particle is inserted in heat circulation drying oven, aeration-drying is to moisture ＜ 8% at 80 DEG C.Packaging：The particle for making is fitted into vinyon pouch, every bag of 8-10g, then the pouch mounted box for installing, vanning, sterilizing (are adopted into 60Co irradiation, irradiation dose is 8kGy）.Finally, irradiated finished product is put in storage by the principle of first in first out.

Claims (2)

1. Hui ethnic group's Chinese medicine " stilbene root cancer of the stomach disappear particle " and preparation method thereof, it is characterised in that it is by made by the raw material of following weight proportion：

Radix Astragali 9g, common sowthistle root 30g, Radix Rabdosiae glaucocalycis 30g, Radix Codonopsis 9g,

Cortex acanthopanacis 9g, Psoralea corylifolia 9g, sealwort 9g, coptis 0.5g,

The lobe of purple garlic 3, honey 30g,

This side is the substantially square of one decoction on the one, in practical application, can also increase 1-3 tastes " dialectical compatibility " medicine according to the physique of patient and conditions.

2. the weight proportion of Hui ethnic group's Chinese medicine according to claim 1 " stilbene root cancer of the stomach disappear particle ", it is characterised in that including following preparation processes：

A、 The preparation of extract

（1）, extract

A, for the first time extraction：By the weight of said herbal medicine in addition to Radix Codonopsis, the coptis, purple garlic, honey, all amplify 10 times, after clean water, it is placed in BT-2 stainless steels to extract in kettle, plus after 7-9 times of running water, is heated to 100 DEG C of constant temperature and extracts 1 hour or so, extraction fluid, pressure filtration, filtrate is standby；

B, second extraction：Add in kettle the 5-7 times of running water measured toward extracting, be heated to 100 DEG C of constant temperature and extract or so half an hour, extraction fluid, pressure filtration, filtrate is standby；

C, third time are extracted：Add in kettle the 3-5 times of running water measured toward extracting, be heated to 100 DEG C of constant temperature and extract 20 minutes or so, extraction fluid, pressure filtration, filtrate is standby；

（2）, concentration

The extract of three times is merged, is placed in B-500 type triple effect vacuum high energy evaporation concentrators, reduced pressure (negative 200mmHg), be heated to 80 DEG C, be concentrated into relative density 1.10～1.20, it is standby；

（3）, powder processed

First 10 times of sections of the lobe of purple garlic 3 amplification are dried or dried in the shade, then Radix Codonopsis 9g, coptis 3g are respectively amplified 10 times, together crushing is end, crosses 80 mesh sieves, standby；

（4）, dispensing

In 300,000 grades of dust proof workshops, medicinal powder is put in mixer together with aforementioned concentrate and honey 50g and is sufficiently mixed, stir；

(5)、 Drying, crushing

The spice being well mixed is placed in into 60-70 DEG C of baking 4-5 hour in baking oven, is then crushed, cross 100 Mesh sieve；

(6), granulate

The spice being well mixed is inserted in comminutor and is granulated；

(7), whole grain

The particle for making is carried out into whole grain, 35 mesh sieves are crossed；

(8), it is dried

Whole good particle is inserted in heat circulation drying oven, aeration-drying is to moisture ＜ 8% at 80 DEG C；

B, packaging

Particle is fitted into vinyon pouch, every bag of 8-10g, then the pouch mounted box for installing, vanning, sterilizing (are adopted into 60Co irradiation, irradiation dose is 8kGy）；

C、 Warehouse-in

Irradiated finished product is put in storage by the principle of first in first out.