CN108186470A - A kind of compound Chinese medicine extract and its application as whitening sunscreen agent - Google Patents
A kind of compound Chinese medicine extract and its application as whitening sunscreen agent Download PDFInfo
- Publication number
- CN108186470A CN108186470A CN201810216275.7A CN201810216275A CN108186470A CN 108186470 A CN108186470 A CN 108186470A CN 201810216275 A CN201810216275 A CN 201810216275A CN 108186470 A CN108186470 A CN 108186470A
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- CN
- China
- Prior art keywords
- chinese medicine
- compound chinese
- medicine extract
- application
- root
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
- A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
- A61K2800/782—Enzyme inhibitors; Enzyme antagonists
Abstract
A kind of application the present invention relates to compound Chinese medicine extract and its as whitening sunscreen agent, more particularly to a kind of common sowthistle root and cortex acanthopanacis compound Chinese medicine extract, the compound Chinese medicine extract shows very strong syneryistic effect in terms of radicals scavenging and tyrosinase inhibition, it is expected to be exploited for preparing cosmetics, especially whitening sunscreen agent.
Description
Technical field
The invention belongs to cosmetic fields, and in particular to a kind of compound Chinese medicine extract and its answering as whitening sunscreen agent
With.
Background technology
Common sowthistle root is the root of feverfew hare's-lettuce, is a kind of Chinese medicine, is distributed in China northeast and southern various regions, has drop
The effect of sugar, lipid-loweringing, clearing deficient heat.Cortex acanthopanacis is the dry root skin of Araliaceae acanthopanax gracilistylus, excavates root in summer, two season of autumn
Portion cleans, strips root skin, dry；There is wind-damp dispelling, tonify the liver and kidney, strengthen muscles and bones, the effect of inducing diuresis for removing edema.Have been reported that wilsonii
Extract can be used for cosmetics, with pigment deposition or tender white muscle skin caused by removing acne.The present invention provides a kind of common sowthistle root and carries
Object and common sowthistle root and cortex acanthopanacis compound extract are taken, common sowthistle root and cortex acanthopanacis in terms of radicals scavenging and tyrosinase inhibition
Between show a kind of effect of synergy.
Invention content
The present invention provides a kind of hare's-lettuce root extract, it is characterised in that the preparation method of the hare's-lettuce root extract is included such as
Lower step：
Dry common sowthistle root is taken, after being crushed, adds in water, refluxing extraction is after 5-10 hours, cooled to room temperature, mistake
Filter, filtrate is through activated carbon decolorizing, concentration, dry the hare's-lettuce root extract.
The preferred distilled water of water or deionized water, the quality dosage of water are 15-30 times of common sowthistle root quality.
Another embodiment of the present invention provides a kind of preparation method of hare's-lettuce root extract, it is characterised in that including as follows
Step：
Dry common sowthistle root is taken, after being crushed, adds in water, refluxing extraction is after 5-10 hours, cooled to room temperature, mistake
Filter, filtrate is through activated carbon decolorizing, concentration, dry the hare's-lettuce root extract.
The preferred distilled water of water or deionized water, the quality dosage of water are 15-30 times of common sowthistle root quality.
Another embodiment of the present invention provides application of the above-mentioned hare's-lettuce root extract as antioxidant.
Another embodiment of the present invention provides application of the above-mentioned hare's-lettuce root extract in terms of free radical is removed.It is described from
By the preferred DPPH free radicals of base, ultra-oxygen anion free radical.
Another embodiment of the present invention provides application of the above-mentioned hare's-lettuce root extract in tyrosinase is inhibited.
Another embodiment of the present invention provides application of the above-mentioned hare's-lettuce root extract as cosmetic additive agent.Describedization
The preferred whitening agent of cosmetic, sun-screening agent etc..
Another embodiment of the present invention provides application of the above-mentioned hare's-lettuce root extract in terms of cosmetics are prepared.
The present invention provides a kind of compound Chinese medicine extract, it is characterised in that the formula of herbal mixture described by weight is
1 part of common sowthistle root, 3-5 parts of cortex acanthopanacis.
Another embodiment of the present invention provides above-mentioned compound Chinese medicine extract, it is characterised in that the herbal mixture extraction
The preparation method of object, includes the following steps：
Dry common sowthistle root and cortex acanthopanacis are measured by formula, mixing after being crushed adds in water, refluxing extraction 5-10 hours
Afterwards, cooled to room temperature, filtering, filtrate is through activated carbon decolorizing, concentration, dry the compound Chinese medicine extract.
The preferred distilled water of water or deionized water, the quality dosage of water are 15-30 times of common sowthistle root and cortex acanthopanacis quality sum.
Another embodiment of the present invention provides the preparation method of above-mentioned compound Chinese medicine extract, it is characterised in that including such as
Lower step：
Dry common sowthistle root and cortex acanthopanacis are measured by formula, mixing after being crushed adds in water, refluxing extraction 5-10 hours
Afterwards, cooled to room temperature, filtering, filtrate is through activated carbon decolorizing, concentration, dry the compound Chinese medicine extract.
The preferred distilled water of water or deionized water, the quality dosage of water are 15-30 times of common sowthistle root and cortex acanthopanacis quality sum.
Another embodiment of the present invention provides application of the above-mentioned compound Chinese medicine extract as antioxidant.
Another embodiment of the present invention provides application of the above-mentioned compound Chinese medicine extract in terms of free radical is removed.It is described
The preferred DPPH free radicals of free radical, ultra-oxygen anion free radical.
Another embodiment of the present invention provides application of the above-mentioned compound Chinese medicine extract in tyrosinase is inhibited.
Another embodiment of the present invention provides application of the above-mentioned compound Chinese medicine extract as cosmetic additive agent.It is described
The preferred whitening agent of cosmetics, sun-screening agent etc..
Another embodiment of the present invention provides application of the above-mentioned compound Chinese medicine extract in terms of cosmetics are prepared.
Common sowthistle root of the present invention, cortex acanthopanacis can be Chinese medicine or the prepared slices of Chinese crude drugs.
Compared with prior art, the advantage of the invention is that：(1) the present invention provides a kind of common sowthistle root water extract,
Certain activity is shown in terms of radicals scavenging and tyrosinase inhibition, cosmetic additive agent can be used as whitening or is prevented
Shine agent；(2) the present invention also provides a kind of common sowthistle roots and cortex acanthopanacis compound Chinese medicine extract, and the compound Chinese medicine extract is in free radical
It removes and tyrosinase inhibition aspect shows very strong syneryistic effect.
Specific embodiment
For the ease of a further understanding of the present invention, examples provided below has done more detailed description to it.But
It is that these embodiments only are not used for limiting the scope of the present invention or implementation principle, reality of the invention for being better understood from inventing
The mode of applying is not limited to the following contents.
Embodiment 1
Dry common sowthistle root (1kg) is taken, after being crushed, adds in distilled water (15kg), refluxing extraction is natural after 5 hours
It is cooled to room temperature, filters, filtrate is through activated carbon decolorizing, concentration, (58.6g is hereinafter referred to as produced dry the hare's-lettuce root extract
Product A).
Embodiment 2
Dry common sowthistle root (1kg) is taken, after being crushed, adds in deionized water (30kg), refluxing extraction is after 10 hours, certainly
So be cooled to room temperature, filter, filtrate through activated carbon decolorizing, concentration, dry the hare's-lettuce root extract (63.5g, hereinafter referred to as
Product B).
Embodiment 3
Dry common sowthistle root (1kg) is taken, after being crushed, adds in distilled water (15kg), at room temperature soak extraction 5 hours
Afterwards, it filters, filtrate is through activated carbon decolorizing, concentration, dry hare's-lettuce root extract (17.3g, hereinafter referred to as products C).
Embodiment 4
Dry common sowthistle root (1kg) is taken, after being crushed, adds in distilled water (15kg), soak extraction 5 is small at 60-70 DEG C
Shi Hou, filtering, filtrate is through activated carbon decolorizing, concentration, dry hare's-lettuce root extract (26.2g, hereinafter referred to as product D).
Embodiment 5
Dry cortex acanthopanacis (1kg) is taken, after being crushed, adds in distilled water (15kg), refluxing extraction is natural after 5 hours
It is cooled to room temperature, filters, filtrate is through activated carbon decolorizing, concentration, dry Cortex Acanthopancis extract (48.5g, hereinafter referred to as product
E)。
Embodiment 6
Formula：1 part of common sowthistle root, 3 parts of cortex acanthopanacis
Dry common sowthistle root (200g) and cortex acanthopanacis (600g) are measured by formula, mixing after being crushed adds in distilled water
(12kg), refluxing extraction is after 5 hours, cooled to room temperature, filtering, and filtrate is through activated carbon decolorizing, concentration, dry described again
Square Chinese medical extract (52.3g, hereinafter referred to as product F).
Embodiment 7
Formula：1 part of common sowthistle root, 5 parts of cortex acanthopanacis
Dry common sowthistle root (200g) and cortex acanthopanacis (1000g) are measured by formula, mixing after being crushed adds in distilled water
(36kg), refluxing extraction is after 10 hours, cooled to room temperature, filtering, and filtrate is through activated carbon decolorizing, concentration, dry described
Compound Chinese medicine extract (64.6g, hereinafter referred to as product G).
Embodiment 8
Formula：0.5 part of common sowthistle root, 5 parts of cortex acanthopanacis
Dry common sowthistle root (100g) and cortex acanthopanacis (1000g) are measured by formula, mixing after being crushed adds in distilled water
(16.5kg), refluxing extraction is after 5 hours, cooled to room temperature, filtering, and filtrate is through activated carbon decolorizing, concentration, dry compound
Chinese medical extract (56.4g, hereinafter referred to as product H).
Embodiment 9
Suitable product A-H is taken to be dissolved with DMSO, the solution that mass concentration is 0.5mg/mL is configured to, according to Chinese patent
Application number：Method described in CN201710843876.6, the DPPH free radical scavenging abilities of test product A-H, super oxygen the moon from
Sub- Scavenging activity；According to Chinese Patent Application No.：Method described in CN201710196028.0, test product A-H is to junket ammonia
The inhibiting rate of sour enzyme, the results are shown in Table 1.
Table 1
Claims (10)
1. a kind of compound Chinese medicine extract, it is characterised in that by weight, the formula of the herbal mixture is 1 part of common sowthistle root,
3-5 parts of cortex acanthopanacis.
2. compound Chinese medicine extract described in claim 1, it is characterised in that the preparation method of the compound Chinese medicine extract, packet
Include following steps：
Dry common sowthistle root and cortex acanthopanacis are measured by formula, mixing after being crushed adds in water, and refluxing extraction is after 5-10 hours,
Cooled to room temperature, filtering, filtrate is through activated carbon decolorizing, concentration, dry the compound Chinese medicine extract.
3. the compound Chinese medicine extract described in claim 2, it is characterised in that the preferred distilled water of the water or deionized water, water
Quality dosage is 15-30 times of common sowthistle root and cortex acanthopanacis quality sum.
4. application of the claim 1-3 any one of them compound Chinese medicine extract as antioxidant.
5. application of the claim 1-3 any one of them compound Chinese medicine extract in terms of free radical is removed.
6. the application described in claim 5, it is characterised in that the preferred DPPH free radicals of the free radical, superoxide anion are free
Base.
7. application of the claim 1-3 any one of them compound Chinese medicine extract in tyrosinase is inhibited.
8. application of the claim 1-3 any one of them compound Chinese medicine extract as cosmetic additive agent.
9. application of the claim 1-3 any one of them compound Chinese medicine extracts in terms of cosmetics are prepared.
10. claim 8-9 any one of them applications, it is characterised in that the preferred whitening agent of the cosmetics, sun-screening agent etc..
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810216275.7A CN108186470B (en) | 2018-03-15 | 2018-03-15 | Compound traditional Chinese medicine extract and application thereof as whitening sunscreen agent |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810216275.7A CN108186470B (en) | 2018-03-15 | 2018-03-15 | Compound traditional Chinese medicine extract and application thereof as whitening sunscreen agent |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN108186470A true CN108186470A (en) | 2018-06-22 |
| CN108186470B CN108186470B (en) | 2020-05-26 |
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ID=62595299
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810216275.7A Active CN108186470B (en) | 2018-03-15 | 2018-03-15 | Compound traditional Chinese medicine extract and application thereof as whitening sunscreen agent |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110664989A (en) * | 2018-07-18 | 2020-01-10 | 广州市尚昇生物科技有限公司 | Striae gravidarum removing composition containing polypeptide and preparation method and application thereof |
Citations (4)
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| CN106668492A (en) * | 2015-11-08 | 2017-05-17 | 银川上河图新技术研发有限公司 | Hui nationality traditional Chinese medicinal Radix Astragali and Sonchus oleraceus L. root stomach cancer treatment pill and preparation method thereof |
| CN106668495A (en) * | 2015-11-08 | 2017-05-17 | 银川上河图新技术研发有限公司 | Hui nationality traditional Chinese medicine radix astragali oral liquid for treating gastric cancer and preparation method thereof |
| CN106668494A (en) * | 2015-11-08 | 2017-05-17 | 银川上河图新技术研发有限公司 | Hui nationality traditional Chinese medicine astragalus membranaceus root stomach cancer-dispersing granules and preparation method thereof |
| CN107551194A (en) * | 2017-09-28 | 2018-01-09 | 东莞市白天鹅纸业有限公司 | It is a kind of that there is the composition for the treatment of eczema effect and the hygenic towelette containing said composition |
-
2018
- 2018-03-15 CN CN201810216275.7A patent/CN108186470B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106668492A (en) * | 2015-11-08 | 2017-05-17 | 银川上河图新技术研发有限公司 | Hui nationality traditional Chinese medicinal Radix Astragali and Sonchus oleraceus L. root stomach cancer treatment pill and preparation method thereof |
| CN106668495A (en) * | 2015-11-08 | 2017-05-17 | 银川上河图新技术研发有限公司 | Hui nationality traditional Chinese medicine radix astragali oral liquid for treating gastric cancer and preparation method thereof |
| CN106668494A (en) * | 2015-11-08 | 2017-05-17 | 银川上河图新技术研发有限公司 | Hui nationality traditional Chinese medicine astragalus membranaceus root stomach cancer-dispersing granules and preparation method thereof |
| CN107551194A (en) * | 2017-09-28 | 2018-01-09 | 东莞市白天鹅纸业有限公司 | It is a kind of that there is the composition for the treatment of eczema effect and the hygenic towelette containing said composition |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110664989A (en) * | 2018-07-18 | 2020-01-10 | 广州市尚昇生物科技有限公司 | Striae gravidarum removing composition containing polypeptide and preparation method and application thereof |
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| CN108186470B (en) | 2020-05-26 |
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Effective date of registration: 20200731 Address after: Floor 3, building 2, No. 3345, fengzhe Road, Fengxian District, Shanghai, 201499 Patentee after: Tianrui (China) Cosmetics Co., Ltd Address before: 225127 No. 199, Yang Hua Xi Road, Yangzhou, Jiangsu Patentee before: YANGZHOU POLYTECHNIC INSTITUTE |