CN106668227A - Hui nationality traditional Chinese medicine radix codonopsis and radix astragali gastric cancer eliminating oral liquid and preparation method thereof - Google Patents

Abstract

The invention discloses a formula of a Hui nationality traditional Chinese medicine radix codonopsis and radix astragali gastric cancer eliminating oral liquid and a preparation method thereof. The oral liquid belongs to a green high-tech Chinese herbal medicine for treating a late gastric cancer, particularly a late gastric cancer which cannot be treated because an operation cannot be performed due to various reasons. The oral liquid belongs to a traditional Chinese medicine oral liquid formed by mixing radix codonopsis, radix astragali, rhizoma coptidis, radix actinidiae chinensis, flos caryophylli and radix gossypii hirsuti according to a certain ratio, boiling with water, extracting and concentrating, mainly treats a gastric cancer, also treats digestive system cancers, such as a pharyngolaryngeal cancer, an esophagus cancer, a carcinoma of gastric cardia and a colorectal cancer, and has the characteristics that drugs are tasteless, the dosage is moderate, and most of selected drugs are proved, through modern medical pharmacological experiments, to be capable of treating cancers.

Description

Hui ethnic group Chinese medicine ginseng stilbene cancer of the stomach disappears oral liquid and preparation method thereof

Technical field

Hui ethnic group's Chinese medicine according to the present invention ginseng stilbene cancer of the stomach oral liquid that disappears is a kind of to treat late gastric cancer especially because the green high-tech Chinese herbal medicine of late gastric cancer that cannot be performed the operation of a variety of causes.The invention further relates to the preparation method of the medicine, belongs to traditional Chinese medicine class.

Background technology

According to《China's tumour registration annual report in 2014》Data display, according to China for each person 74 years old life-span calculate, Chinese all one's life suffer from malignant tumour probability be 22%, average minute clock has 6 people to be diagnosed as malignant tumour, and tumour has become a kind of common disease in China.At present the cancer patient of China is about ten thousand people more than 700, and every year with the speed of more than 100 ten thousand people in increase.And the whole world

According to statistics, in the cancer patient of China nearly 8,000,000, have 31.27% for Alimentary System patient, wherein patients with gastric cancer accounts for the 41.83% of Alimentary System patient, almost half.

China is one of incidence gastric cancer rate highest country, and the whole world is annual newly to send out patients with gastric cancer more than 100 ten thousand, and China just account for 42%, and death toll China has accounted for 35%, and the M ＆ M of Chinese cancer of the stomach is world average level more than 2 times！Inherent cause among these, immune factor, helicobacter pylori infections factor are all nothing difficult, and most anxious is then environment and dietary factor ...

The early symptom of cancer of the stomach is not obvious, generally needs time of 2 years or so from incidence gastric cancer to finding tumour, therefore often ignored, once and to standing, most likely reach an advanced stage.

It is operation to control cancer of the stomach the best way at present, postoperative to be also performed to chemotherapy, and chemotherapy not only large side effects, patient suffering is difficult to stand, and success rate is also very low, 1 year life cycle after most Chemotherapy in Patients less than --- certainly this is also relevant with the over-treatment given birth to without skilful doctor.And on the other hand, although some are detected to be cancer of the stomach, because a variety of causes cannot be performed the operation,Can only palliative treatment, expect that miracle comes ...

Cancer of the stomach is at present more refractory disease more, but refractory representative cannot be controlled, and in addition to above-mentioned western medical treatment method, the traditional Chinese medical science also has many effectively treatment methods.The traditional Chinese medical science, according to the whole body feature diagnosis and treatment of patient, goes for various each phase cancer with organic conception.The advantage of Chinese medicine cancer is to be conducive to stablizing the state of an illness, and toxic and side effect is slight, symptom improves more apparent, slows down PD, tumor regression or the longer-term existence of band knurl, and patient is easy to receive and expense is than less expensive.At present doctor trained in Western medicine is also considered as traditional Chinese medicine can contribute to reducing the toxicity of Radiotherapy chemotherapy as the auxiliary treatment of cancer, improve cancer related symptoms, improve life quality, extend life cycle.But exist problem be the traditional Chinese medical science prescription uniformity it is poor, treatment mainly be experience.From in terms of existing proved recipe for cancer, folk prescription, always there is --- majority is more than more than half --- medicine to be all not prove " compatibility " medicine of function for cancer and effect " diagnosis and treatment based on an overall analysis of the illness and the patient's condition " by modern medicine pharmacological evaluation in selected Chinese herbal medicine medicinal material, inventors believe that very improper；And folk prescription, folk prescription cure the disease lean on be test, often stop over the time cured the disease.

The content of the invention

The purpose of the present invention, be aiming at Cancer in China patient assessment be difficult to and in the side's of curing the desease poor consistency, repeatable poor, high level evidence-based medicine EBM be theoretical and the relative shortage of evidence,Thus the situation for waiting deficiency by rule of thumb that is mainly for cancer, propose a kind of new dosage and preparation method, there is provided one kind reduces the incidence of disease of cancer of the stomach from the beginning of prevention, start to slow down its tempo from canceration, the green high-tech Chinese herbal medicine for inducing its atrophy apoptosis is started from tumour.Specifically, the present invention one be particularly suited for use in treatment cancer before larger gastric ulcer in case its canceration, two is the especially big gastric ulcer that can treat the cancer of the stomach initial stage, in case it continues to deteriorate, three are can induce into the cancerous swelling atrophy apoptosis of knurl, with very low cost, fundamentally improve physical function, so as to get well.Its sharpest edges are to greatest extent to induce self apoptosis of cancer cell and differentiation, promote cancerous swelling progressively atrophy.In specific formula, also coordinate diagnosis and treatment based on an overall analysis of the illness and the patient's condition, according to the origin cause of formation of cancer of the stomach because dietary factor makes nutrient disequilibrium cause immunologic hypofunction, because Helicobacter pylori infection causes stomach normal cell to be compromised, apoptosis, gastritis, digestive tract ulcer, lymphoproliferative gastric lymphoma " is taken advantage of a weak point " evil poison positive pressure, flee channels and collaterals visitor the characteristics of internal organs form long product and cause the basic pathology interpretation of the cause, onset and process of an illness such as Metastasis of Gastric Cancer because evil poison being tied in sick protracted blood stasis and being wrapped hemostasis and is taken advantage of a weak point in opponent's defence, with the tonifying speen and tonifying kidney strengthening vital QI to eliminate pathogenic factors method that tonification and purgation in combination, it is empty in healthy tendency to correct, poly- and internal organs imbalance of yin and yang function reduction the deficiency of the solidifying poison of heresy, adjust and improve the immunologic function of body.Simultaneously according to the concrete condition of patient, different formulas, or easypro liver and stomach, drop check pain, or detoxification and removing stasis, clearing heat and nourishing yin, or warming spleen and stomach for dispelling cold, strengthening the spleen and stomach, or strongly invigorating QI and blood are respectively adopted, strengthening spleen, tonifying kidney ... is reachingTonification and purgation in combination, reinforcing and reducing methods and use, the purpose of overall tumor suppression, so as to improve the overall curative effect and late result of curing gastric cancer, a kind of green high-tech Chinese herbal medicine formula and compound method that function for cancer and effect are proved by modern medicine pharmacological evaluation is provided for patients with gastric cancer, with very low or relatively low cost, fundamentally improve physical function, the deterioration of symptom management simultaneously makes the state of an illness gradually take a turn for the better, and finally recovers healthy.Thus also to patient one select different treatment methods or several method to share particularly traditional Chinese and western medicine to combine the leeway of complex treatment application to consider according to the personal state of an illness, economic situation, personal inclination, to obtaining optimum curative effect, survival rate is easily improved --- particularly more than 5 years survival rates.

Technical scheme proposed by the invention is：

The Hui ethnic group Chinese medicine ginseng stilbene cancer of the stomach of the first, described treatment cancer of the stomach disappears oral liquid and preparation method thereof, is by made by following weight proportion raw material：

Radix Codonopsis 9g, Radix Astragali 9g, coptis 3g, Chinese actinidia root 30g,

Cloves 9g, dark plum 9g, Levant Cotton Root 30g hairyvein agrimony 10g,

Honey 5g

This side is substantially square for one decoction on the one.In practical application, also 1-3 tastes " dialectical compatibility " medicine can be increased according to the physique of patient and conditions.

In view of with this, basic side's decoction decoction of medicinal ingredients amount is big, taste is not good enough, patient is difficult to drink, therefore must be prepared using special process.

2nd, it is by the preparation method that above-mentioned each raw material makes traditional Chinese medicine oral liquid of the present invention：

A, extract preparation

（1）, extract

A, for the first time extraction：By the weight of said herbal medicine in addition to Radix Codonopsis, the coptis, honey, all amplify 10 times, after clean water, it is placed in BT-2 stainless steels to extract in kettle, plus after 7-9 times of running water, is heated to 100 DEG C of constant temperature and extracts 1 hour or so, extraction fluid, pressure filtration, filtrate is standby.

B, second extraction：Add in kettle the 5-7 times of running water measured toward extracting, be heated to 100 DEG C of constant temperature and extract or so half an hour, extraction fluid, pressure filtration, filtrate is standby.

C, third time are extracted：Add in kettle the 3-5 times of running water measured toward extracting, be heated to 100 DEG C of constant temperature and extract 20 minutes or so, extraction fluid, pressure filtration, filtrate is standby.

（2）, concentration

The extract of three times is merged, is placed in B-500 type triple effect vacuum high energy evaporation concentrators, reduced pressure (negative 200mmHg), be heated to 80 DEG C, be concentrated into 900ml, it is standby.

（3）, powder processed

Radix Codonopsis 9g, coptis 3g are respectively amplified 10 times, it is end together to crush, and crosses 80 mesh sieves, and in being fitted into capsule, every 0.5g is standby.

（4）, dispensing

In 300,000 grades of dust proof workshops, aforementioned concentrate and honey 50g are put in mixer be sufficiently mixed together, stir.

B, packaging

A. in concentrate being fitted into into vial or vinyon bottle, every bottle of 30ml, mounted box, vanning, sterilizing (adopt 60Co irradiation, irradiation dose is 8kGy）.

B. in capsule being fitted into into vial or vinyon bottle, mounted box, vanning, sterilizing (adopt 60Co irradiation, irradiation dose is 8kGy）.

C, warehouse-in

Irradiated finished product is put in storage by the principle of first in first out.

Routine instructions of taking of the invention：Above-mentioned oral liquid three times a day, 1 bottle every time, on an empty stomach (taking half an hour after can not drink water in a large number, in order to avoid water down liquid).7-9 grain capsules are taken while each taking oral liquid.The pungent grade food larger to gastrointestinal irritation is not eaten during medication.This medicine is a course for the treatment of in three months, typically takes two to three courses for the treatment of, at most takes four courses for the treatment of.

The effect of each raw material of the present invention：

Radix Codonopsis,Effect and effect：" tonifying middle-Jiao and Qi, promotes the production of body fluid, invigorating the spleen, and taste, relieving thirst and restlessness." traditional Chinese medical science thinks Radix Codonopsis flat property and sweet taste, returns spleen, lung channel, the effect of have tonifying middle-Jiao and Qi, strengthening spleen and tonifying lung, can be used for the diseases such as spleen and lung weakness, shortness of breath palpitations, anorexia and loose stool, virtual asthma cough, Heat Diabetes.And newest scientific research discovery, the various nutriments contained in Radix Codonopsis, the body immunity to people, blood vessel, and other organs are helpful.Radix Codonopsis can promote blood in human body in liquid to circulate, while also hematopoiesis regeneration, promotes the effect of red blood cell growth.So as to effectively help people to strengthen body immunity, fitness is improved.Radix Codonopsis has good opsonic action to the digestive system of people.Not only when pathology has occurred in the digestive system of people, disease can be treated using Radix Codonopsis, such as can be nursed one's health by taking Radix Codonopsis decoction when the gastroxia of people, and, usually some Radix Codonopsis just can in advance be taken when, to prevent the disease of digestive system, and the health for promoting digestive system.Because Radix Codonopsis also has certain opsonic action to the immune system of people, therefore some Radix Codonopsis products are eaten, the immunocompetence that can make the person rises, and reduces the incidence of human body diseases.Except, Radix Codonopsis also adjusts cardio-cerebrovascular function, promotes the effect of cardio-cerebrovascular health;Particularly there is hematopoiesis, blood pressure, the effect of reducing blood pressure etc. is adjusted.

The Radix Astragali,The Radix Astragali is sweet, tepor.Returns spleen, lung channel.Tonifying spleen lung qi, yang invigorating, benefit defends solid table, diuresis, promoting pus discharge and tissue regeneration.The Radix Astragali is the dry root of legume astragalus mongolicus Astragalus membranacus.Containing amino acid, mucilaginous substance, carbohydrate, bitter principle, choline glycine betaine folic acid, kumatakenin, cupreol（, astragalus polyose etc..It is allCancerPatient is white because of spleen-lung Qi deficiency caused complexion white light, lassitude, receives few loose stool, and hematemesis hematochezia, cough and asthma shortness of breath, abundant expectoration is dilute white, deficiency of QI with disinclination to talk, weak spontaneous perspiration, palpitation and insomnia, fever due to deficiency of vital energy, and edema oliguria etc. can use it.The Radix Astragali can strengthen the phagocytic function of reticuloendothelial system, have facilitation to interferon system, have completeness Immunonormalizing action to cancer patient lymphocytes' function, have fabulous curative effect to precancerous lesion gastric ulcer.

The coptis,Nature and flavorEffect：It is bitter, cold in nature.Heat-clearing and damp-drying drug, purging intense heat and detonicating.It is clinicalUsing：Suitable for various arsine knurls, such as liver, courage tumour, tongue cancer, lip cancer, the cancer of the esophagus,Cancer of the stomach, carcinoma of urinary bladder etc..Additionally, apply also for unconsciousness due to high fever, haematemesis, bleeding from five sense organs or subcutaneous tissue, furuncle swelling toxin, the disease such as wet sore itch, acute conjunctivitis, aphtha, bacillary dysentery, acute bowel helmet are scorching, heat contains vexed, feeling of fullness, quenches one's thirst, burn.

Chinese actinidia root,Nature and flavor are sour, puckery, cool.Indication：Clearing heat and detoxicating, clearing heat and promoting diuresis is preventedTumourAnticancer, dispelling wind and eliminating dampness, diuresis hemostasis, removing toxicity for detumescence,Indigestion, vomiting, arthralgia due to wind-dampness, treating rheumatic ostealgia, Alimentary Tract Cancer, tumor in digestive tract, large carbuncle boil, the disease such as treating rheumatic ostealgia and jaundice.Be generally used to treat abdominal tumor heat-clearing and detoxifying drug, particularly with intestines and stomach in terms of cancer applications it is more, with strengthen cellular immunity and suppress humoral immunity effect, its antitumor action may with its promote lymphocyte transformation and enhancing NK cytoactives it is relevant.

Levant Cotton Root,Nature and flavorEffect：Sweet, warm in nature, tonifying Qi, Zhichuan is relievingd asthma.Cotton root skin containsGossypol, flavones, Acetovanillone,Glycine betaine, sterol,Salicylic acidDeng；Root containsSaponin,PhenolComposition；Gossypium hirsutum L contain gossypol, cotton purpurin,Arginine,Asparagus fernAcid amides, glycine betaine,Oxalic acid, salicylic acid,Oleic acid,Palmitic acidAnd it is a small amount ofVolatile oil, contain in volatile oilFurfural, Acetovanillone.It is clinicalUsing：Suitable for kinds of tumors, such as lung cancer, liver cancer, spermatogonium cancer,Cancer of the stomach, the cancer of the esophagus and bottleneck throat tumour etc..Additionally, being also suitable for chronic bronchitis, body void edema, sub-official prolapses etc..

Cloves,Nature and flavor are pungent, temperature, nontoxic.Enter lung, spleen, stomach, the Jing of kidney four.Indication：Middle benefit gas, warm up kidney, drop inverse.Hiccup is controlled, is vomitted, gastric disorder causing nausea, rush down dysentery, trusted subordinate's crymodynia, Xuan addictions, hernia, tinea, promoting qi circulation and relieving pain.This product taste is pungent, gas fragrance, pungent energy promoting qi circulation and relieving pain commonly uses pain in the chest due to obstruction of QI, abdominal pain, hypogastric pain, hernia pain.Cloves is the reasonable Chinese medicine of narcotic analgesic.Warm kidney and enhancing body.This product is warm in nature, enters kidney channel.Therefore have the effect of warm kidney and enhancing body, it is usually used in the cards such as impotence, sombre, run quickly globefish, waist-leg crymodynia.Anti-gastric-ulcer：Volatile clove oil and eugenol dramatically increase can stomach mucilage secretion, and acidity does not increase.Eugenol is probably antiulcer active component.Stomach invigorating：Belly flatulence can be alleviated, strengthen digestion power, mitigate n and V.Anti diar rhea：The big enteral diarrhea that its water extract and eugenol energy antagonism folium sennae or castor oil cause and enteric cavity hydrops.The traditional Chinese medical science thinks, cloves taste is pungent, warm in nature, and with middle benefit gas effect that is inverse, tonifying the kidney and support yang is dropped.Its still good temperature stomach medicine simply, to caused by cold-evil stomachache, vomiting, hiccup, suffer from abdominal pain, have loose bowels and the cold dysmenorrhoea of women etc., have good curative effect, it can also alleviate belly flatulence, strengthen digestion power, mitigate n and V, especially pregnant woman and suffer from morning sickness symptom.Cloves contains caryophyllus oil, for pathogenic fungus and staphylococcus, dysentery and Escherichia coli etc. have inhibitory action, can also make external application, has good curative effect to ringworm of the body and tinea pedis.

Dark plum,Nature and flavorEffect：Sour-puckery flavor, it is warm in nature.Astringe the lung puckery intestines, promote the production of body fluid to quench thirst.CanTreatmentCancerous swelling.Be clinically used for treat carcinoma of penis,Cervical carcinoma, colon and rectum carcinoma, the cancer of the esophagus,Cancer of the stomachDeng.Additionally, being additionally operable to treat chronic cough of deficiency lung, dry polydipsia, ascarid of biliary tract, cholecystitis, bacillary dysentery, chronicDiarrhoea, Lu pass through many, psoriasis.External curing ulcer does not close up long, corn etc..

Hairyvein agrimony,Nature and flavor are bitter, puckery, put down.The thoughts of returning home, Liver Channel.Indication：Astringing to arrest bleeding, preventing malaria, only dysentery, detoxifies.For hemoptysis, spit blood, metrostaxis, malaria, bloody flux, de-power internal lesion caused by overexertion, carbuncle sore tumefacting virus, pruritus vulvae under band.Early in the Ming Dynasty, China physician Jiang Yi just willHairyvein agrimonyFor treatingCancer of the esophagusWithCancer of the stomach.He writes in curing：" rolling pharynx every phlegm, flat regurgitation it is dirty ", swallow every regurgitation be ancients to describe the illness of cancer of the esophagus and cancer of the stomach, " always doctor's faciation fear, think incurable disease." " remaining to obtain this agent, ten throw nine imitates ".CancerPatient is taken after hairyvein agrimony, such as " grain of famine, the fur coat in midwinter ".Modern medicine study finds that hairyvein agrimony extract at least contains 12 kinds of compositions, and its major part is in cancer resistance.

Honey,Effect of honey and effect：1. the good merchantable brand of cardiovascular patient,HoneyThe composition of blood can be improved, promote heart and brain and vascular function, therefore Jing informal dresses very good for cardiovascular patient；2. protect liver, honey to have protective effect to liver, liver cell regeneration can be promoted, the formation to fatty liver has certain inhibitory action；3. build up resistance, edible honey can regain one's strength of body rapidly, dispelling fatigue builds up one's resistance to disease；4. sterilized, honey also has sterilized effect, Jing often to eat honey, not only without prejudice to tooth, moreover it is possible to play a part of sterilizing in oral cavity, honey can treat the skin damage of moderate, particularly scald, when honey is regarded into skin wound dressing, bacterium cannot grow；5. promote sleep, the people of the insomnia oral 1 soupspoon honey (in 1 glass of warm water of addition) before sleep daily to help fall asleep as early as possible；6. promote gastrointestinal peristalsis, honey to have adjustment effect to gastrointestinal function, gastric acid secretion can be made normal.Zoopery confirms that honey plays the role of to strengthen enterocinesia, can significantly shorten defecation time.

The effect of the present invention：

Cure mainly：Cancer of the stomach, especially because a variety of causes cannot carry out the late gastric cancer of Surgery for Gastric Carcinoma, with very low cost, fundamentally improves physical function, and control tumour continues to overgrow and makes it that final disappearance is gradually reduced, so as to recover healthy.

It is simultaneous to control：The cancer in digestive system such as throat cancer, the cancer of the esophagus, cardiac cancer, pylorus cancer, colorectal cancer.

Our the characteristics of is：

1st, flavour of a drug are more, and dosage is moderate, do not waste.

2nd, selected flavour of a drug are mostly that proved by modern medicine pharmacological evaluation can be for cancer, and existing proved recipe for cancer, then always there are medicines more than half to be all not proved function for cancer and effect by modern medicine pharmacological evaluation in folk prescription.

3rd, for focus, arrow arrow punching, i.e., selected flavour of a drug all especially grow tender of and hit the bull's eye, and As the medicine took effect, the symptoms lessened.As long as rather than it is for cancer, just jump on the bandwagon, being as a result that " dragon " is more bad on the contrary harnesses the river.

4th, as much as possible " neutralisation ", i.e., selected flavour of a drug generally keep " neutrality ", do not tremble with fear not dry, not hot not cool.Patient can be thus set to suffer less within the cycle of whole medication, pull the devil by the tail less.And if really there is the situation of " getting angry " or " under let out ", then can be directed to concrete individual concrete condition completely, add a bit " stopping leak ", the medicine of " fall fire " dialectically temporarily and specifically solve.Rather than imagine at the very start patient may on tell or drop, and some unnecessary medicines are added to prescription, patient is all taken always during very long very long medication, ultimately cause adverse consequences.

Specific embodiment：Chinese actinidia root 30g, Radix Astragali 9g, cloves 9g, dark plum 9g, Levant Cotton Root 30g, hairyvein agrimony 10g are respectively amplified into 10 times, after clean water, BT-2 stainless steels is placed in and is extracted in kettle, plus after 7-9 times of running water, be heated to 100 DEG C of constant temperature and extract 1 hour or so, extraction fluid, pressure filtration, filtrate is standby.Extract for second：Add in kettle the 5-7 times of running water measured toward extracting, be heated to 100 DEG C of constant temperature and extract or so half an hour, extraction fluid, pressure filtration, filtrate is standby.Third time is extracted：Add in kettle the 3-5 times of running water measured toward extracting, be heated to 100 DEG C of constant temperature and extract 20 minutes or so, extraction fluid, pressure filtration, filtrate is standby.Concentration：The extract of three times is merged, is placed in B-500 type triple effect vacuum high energy evaporation concentrators, reduced pressure (negative 200mmHg), be heated to 80 DEG C, be concentrated into relative density 1.10～1.20, it is standby.Powder processed：Radix Codonopsis 9g, coptis 3g are respectively amplified 10 times, it is end together to crush, and crosses 80 mesh sieves, standby.Dispensing：In 300,000 grades of dust proof workshops, medicinal powder is put in mixer together with aforementioned concentrate and 50g honey and is sufficiently mixed, stir.Packaging：A. in concentrate being fitted into into vial or vinyon bottle, every bottle of 30ml, mounted box, vanning, sterilizing (adopt 60Co irradiation, irradiation dose is 8kGy）.B. in capsule being fitted into into vial or vinyon bottle, mounted box, vanning, sterilizing (adopt 60Co irradiation, irradiation dose is 8kGy）.Finally, irradiated finished product is put in storage by the principle of first in first out.

Claims (2)

1. Hui ethnic group's Chinese medicine ginseng stilbene cancer of the stomach disappears oral liquid and preparation method thereof, it is characterised in that it is by made by the raw material of following weight proportion：

Radix Codonopsis 9g, Radix Astragali 9g, coptis 3g, Chinese actinidia root 30g,

Cloves 9g, dark plum 9g, Levant Cotton Root 30g hairyvein agrimony 10g, honey 50g

This side is the substantially square of one decoction on the one, in practical application, can also increase 1-3 tastes " dialectical compatibility " medicine according to the physique of patient and conditions.

2. the Hui ethnic group Chinese medicine ginseng stilbene cancer of the stomach according to claim 1 disappears the weight proportion of oral liquid, it is characterised in that including following preparation processes：

The preparation of A, extract

（1）, extract

A, for the first time extraction：By the weight of said herbal medicine in addition to Radix Codonopsis, the coptis, honey, all amplify 10 times, after clean water, it is placed in BT-2 stainless steels to extract in kettle, plus after 7-9 times of running water, is heated to 100 DEG C of constant temperature and extracts 1 hour or so, extraction fluid, pressure filtration, filtrate is standby；

B, second extraction：Add in kettle the 5-7 times of running water measured toward extracting, be heated to 100 DEG C of constant temperature and extract or so half an hour, extraction fluid, pressure filtration, filtrate is standby；

C, third time are extracted：Add in kettle the 3-5 times of running water measured toward extracting, be heated to 100 DEG C of constant temperature and extract 20 minutes or so, extraction fluid, pressure filtration, filtrate is standby；

（2）, concentration

The extract of three times is merged, is placed in B-500 type triple effect vacuum high energy evaporation concentrators, reduced pressure (negative 200mmHg), be heated to 80 DEG C, be concentrated into 900ml, it is standby；

（3）, powder processed

Radix Codonopsis 9g, coptis 3g are respectively amplified 10 times, it is end together to crush, and crosses 80 mesh sieves, and in being fitted into capsule, every 0.5g is standby；

（4）, dispensing

In 300,000 grades of dust proof workshops, aforementioned concentrate and honey 50g are put in mixer be sufficiently mixed together, stir；

B, packaging

A. in concentrate being fitted into into vial or vinyon bottle, every bottle of 30ml, mounted box, vanning, sterilizing (adopt 60Co irradiation, irradiation dose is 8kGy）；

B. in capsule being fitted into into vial or vinyon bottle, mounted box, vanning, sterilizing (adopt 60Co irradiation, irradiation dose is 8kGy）；

C, warehouse-in

Irradiated finished product is put in storage by the principle of first in first out.