CN104095930A - Traditional Chinese medicine for treating gastrorrhagia - Google Patents
Traditional Chinese medicine for treating gastrorrhagia Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine for treating gastrorrhagia, which is prepared from the following raw materials in parts by weight: 25-45 parts of eclipta, 20-30 parts of herba cepbalanoplosis segeti, 15-30 parts of wood ear, 5-15 parts of Nodus Nelumbinis Rhizomatis, 2-9 parts of liquorice and 5-10 parts of Angelica sinensis. The traditional Chinese medicine used for treating the gastrorrhagia and provided by the invention is short in course of treatment, effective in treatment and convenient to take and saves time.
Description
Technical field
The present invention relates to technical field of Chinese medicines, particularly a kind of Chinese medicine for the treatment of gastrorrhagia.
Background technology
Gastrorrhagia is commonly called as upper gastrointestinal hemorrhage, more than 40% is to be caused by Stomach duodenum ulcer, and overwork fatigue, diet is irregular, mood disorders is nervous etc. has the crowd of digestive tract medical history easily to fall ill; Next is the gastrorrhagia that acute haemorrhagic gastritis causes, and the gastrorrhagia major part that these two kinds of reasons cause can obtain effective treatment after regular treatment.Be the gastrorrhagia that liver cirrhosis causes in addition, patient with liver cirrhosis generally all can develop into esophagus fundus ventricularis varication, if eat roughage, emotion overstimulation, massive hemorrhage will occur in the vein blood vessel explosion of Gastroesophageal again.The mortality rate of gastrorrhagia is up to 8～13.7%.
The clinical manifestation of gastrorrhagia is: hematemesis and (or) melena, losing blood property peripheral circulatory failure, azotemia, anemia and blood change and heating.Wherein, hematemesis and (or) melena are the characteristic performances of upper gastrointestinal hemorrhage.Often there are hematemesis and melena in bleeding part the above person of pylorus, the following person of pylorus, can only show as melena.But the above pathological changes of the few and slow-footed pylorus of amount of bleeding can rarely seen melena, and pathological changes below large, the fireballing pylorus of amount of bleeding can flow into stomach because of blood reflux, causes hematemesis.
At present, the medicine for the treatment of gastrorrhagia has a lot, doctor trained in Western medicine is taken Western medicine to the Therapeutic Principle of gastrorrhagia, by reducing Acidity in the stomach in case hydrion back diffusion increases the weight of gastric mucosa damage, actively hemostasis, and be aided with blood transfusion infusion, treatment time is short, but treatment curative effect is not very desirable, and easily recurrence, side effect is large; Chinese patent medicine side effect is little, but treatment time is long, and the composition of medicine is comparatively complicated, and therapeutic effect is not obvious.In recent years, Chinese medicine, because its toxic and side effects is little, evident in efficacy, enjoys gastrorrhagia patient's favor, finds a kind of curative effect fast, and effect is remarkable, and the Chinese medicine that toxic and side effects is little is treated gastrorrhagia and become most important.
Summary of the invention
Technical problem to be solved by this invention is to provide the Chinese medicine of the treatment gastrorrhagia that a kind of curative effect is fast, toxic and side effects is little.
For achieving the above object, the present invention takes following technical scheme:
Treat a Chinese medicine for gastrorrhagia, by the raw material of following weight portion, made: 25～45 parts of Herba Ecliptaes, 20～30 parts of Herba Cirsiis, 15～30 parts, Auricularia, 5～15 parts of Nodus Nelumbinis Rhizomatis, 2～9 parts, Radix Glycyrrhizae.
The Chinese medicine for the treatment of gastrorrhagia of the present invention, its preparation method is as follows:
(1) Herba Ecliptae, Herba Cirsii, Auricularia, Nodus Nelumbinis Rhizomatis, Radix Glycyrrhizae powder are broken into 150～300 order powder, add 3～4 times of water of raw material gross weight, 1%～2% cellulase and 1%～2% pectase that add again raw material gross weight, 40 ℃～45 ℃ lixiviates 2～3 hours, filter, collect lixiviating solution, by filtering residue dry for standby;
(2) in standby filtering residue, add 8～12 times of ethanol of filtering residue gross weight, reflux, extract, 25～35min, collects extracting solution for the first time; Add 5～8 times of ethanol of filtering residue gross weight, reflux, extract, 30～40min, collects extracting solution for the second time again; Add 3～5 times of ethanol of filtering residue gross weight, reflux, extract, 35～45min, collects extracting solution for the third time again, merge three times extracting solution, obtain extracting solution, described ethanol volumetric concentration is 65%～95%, and described three reflux, extract, are all extracted at 40 ℃～50 ℃ temperature.
(3) lixiviating solution and extracting solution are merged, compression, spraying is dry, makes the Chinese medicine powder for the treatment of gastrorrhagia.
The Chinese medicine for the treatment of gastrorrhagia of the present invention, preferably, is made by the raw material of following weight portion: 30～40 parts of Herba Ecliptaes, 23～27 parts of Herba Cirsiis, 20～25 parts, Auricularia, 10～13 parts of Nodus Nelumbinis Rhizomatis, 5～8 parts, Radix Glycyrrhizae.
The Chinese medicine for the treatment of gastrorrhagia of the present invention, best, is made by the raw material of following weight portion: 35 parts of Herba Ecliptaes, 25 parts of Herba Cirsiis, 23 parts, Auricularia, 12 parts of Nodus Nelumbinis Rhizomatis, 6 parts, Radix Glycyrrhizae.
In raw material of the present invention, also comprise 5～10 parts of Radix Angelicae Sinensis.
The Radix Angelicae Sinensis also comprising in raw material of the present invention is preferably 8 parts.
Take for convenience, the Chinese medicine powder for the treatment of gastrorrhagia of the present invention can be made into tablet or pill.
In the Chinese medicine raw material for the treatment of gastrorrhagia of the present invention:
Herba Ecliptae is the aerial parts of feverfew Eclipta prostrata Eclipta prostrata L..Nature and flavor: sweet in the mouth acid, cool in nature, enter Liver and kidney two warps, nontoxic.Function cures mainly: nourishing the liver and kidney, cooling blood for hemostasis, can control various haematemesis, the hemorrhage grade of the intestines and stomach disease.
Herba Cirsii is the aerial parts of feverfew field thistle Cephalanoplos segetum (Bunge) Kitam..Nature and flavor: sweet, bitter, cold.Function cures mainly: cooling blood for hemostasis, removing blood stasis to reduce swelling; For epistaxis, to spit blood, hematuria, has blood in stool, metrostaxis, traumatic hemorrhage, carbuncle sore tumefacting virus.
Auricularia is that (formal name used at school: edible fungi Auricularia or Wood ear) is sporophore colloid becomes disc, the irregular shape of ear shape, diameter 3-12 centimetre to Auricularia.Nature and flavor: mouthfeel is delicate, and local flavor is special.Function cures mainly: fills blood, and lung moistening, hemostasis; For Qi and blood deficiency, extremity are twitched, cough due to deficiency of the lung, and spitting of blood, spits blood, epistaxis, metrorrhagia, hypertension, constipation.
Nodus Nelumbinis Rhizomatis: be Rhizoma Nelumbinis coupling part.Nature and flavor: property is flat, sweet-puckery flavor.Function cures mainly: have the effect of hemostasis scattered silt, control hemoptysis, haematemesis, hematuria, have blood in stool, metrorrhagia etc.
Radix Angelicae Sinensis is herbaceos perennial root.Nature and flavor: sweet, pungent, temperature.Function cures mainly: enrich blood, invigorate blood circulation, menstruction regulating and pain relieving, moisturizes laxation.
Radix Glycyrrhizae is pulse family, Glycyrrhiza perennial herb root and rhizome.Nature and flavor: sweet, flat.Function cures mainly: heat-clearing and toxic substances removing, expelling phlegm for arresting cough, gastral cavity abdomen etc.
Compared with prior art, beneficial effect of the present invention is:
(1) reasonable recipe, not hemostasis merely, also have removing heat from blood, blood tonification effect, treating both the principal and the secondary aspects of a disease at the same time, as the Auricularia containing in Chinese medicine, not only can stop blooding but can removing heat from blood, enrich blood, the Radix Angelicae Sinensis adding has the effect of enriching blood, and is beneficial to patient and recovers, and Radix Glycyrrhizae has the property of medicine of mediation effect, strengthen drug effect, other component is hemostasia effect.
(2) Time of Administration is short, instant effect, and Chinese medicine is made tablet or pill, conveniently takes, and saves time.
(3) in the present invention without any additive, toxic and side effects is little.
The specific embodiment
Below in conjunction with embodiment, the invention will be further described, but the present invention is not limited to these embodiment.
Embodiment 1
Treat a Chinese medicine for gastrorrhagia, by the raw material of following weight portion, made: 25 parts of Herba Ecliptaes, 20 parts of Herba Cirsiis, 15 parts, Auricularia, 5 parts of Nodus Nelumbinis Rhizomatis, 2 parts, Radix Glycyrrhizae, 5 parts of Radix Angelicae Sinensis.
(1) Herba Ecliptae, Herba Cirsii, Auricularia, Nodus Nelumbinis Rhizomatis, Radix Glycyrrhizae powder are broken into 150 order powder, add 3 times of water of raw material gross weight, then add 1% cellulase and 1% pectase of raw material gross weight, 40 ℃ of lixiviates 2 hours, filter, collect lixiviating solution, by filtering residue dry for standby;
(2) in standby filtering residue, add 8 times of ethanol of filtering residue gross weight, reflux, extract, 25min, collects extracting solution for the first time; Add 5 times of ethanol of filtering residue gross weight, reflux, extract, 30min, collects extracting solution for the second time again; Add 3 times of ethanol of filtering residue gross weight, reflux, extract, 35min, collects extracting solution for the third time again, merges three times extracting solution, obtains extracting solution, and described ethanol volumetric concentration is 65%, and described three reflux, extract, are all carried out at 40 ℃ of temperature;
(3) lixiviating solution and extracting solution are merged, compression, spraying is dry, makes the Chinese medicine powder for the treatment of gastrorrhagia, and Chinese medicine powder is made to tablet.
Embodiment 2
Treat a Chinese medicine for gastrorrhagia, by the raw material of following weight portion, made: 30 parts of Herba Ecliptaes, 23 parts of Herba Cirsiis, 20 parts, Auricularia, 10 parts of Nodus Nelumbinis Rhizomatis, 5 parts, Radix Glycyrrhizae, 6 parts of Radix Angelicae Sinensis.
(1) Herba Ecliptae, Herba Cirsii, Auricularia, Nodus Nelumbinis Rhizomatis, Radix Glycyrrhizae powder are broken into 180 order powder, add 4 times of water of raw material gross weight, then add 2% cellulase and 2% pectase of raw material gross weight, 42 ℃ of lixiviates 2.5 hours, filter, collect lixiviating solution, by filtering residue dry for standby;
(2) in standby filtering residue, add 9 times of ethanol of filtering residue gross weight, reflux, extract, 30min, collects extracting solution for the first time; Add 7 times of ethanol of filtering residue gross weight, reflux, extract, 35min, collects extracting solution for the second time again; Add 4 times of ethanol of filtering residue gross weight, reflux, extract, 40min, collects extracting solution for the third time again, merges three times extracting solution, obtains extracting solution, and described ethanol volumetric concentration is 70%, and described three reflux, extract, are all carried out at 45 ℃ of temperature;
(3) lixiviating solution and extracting solution are merged, compression, spraying is dry, makes the Chinese medicine powder for the treatment of gastrorrhagia, and Chinese medicine powder is made to tablet.
Embodiment 3
Treat a Chinese medicine for gastrorrhagia, by the raw material of following weight portion, made: 35 parts of Herba Ecliptaes, 25 parts of Herba Cirsiis, 23 parts, Auricularia, 12 parts of Nodus Nelumbinis Rhizomatis, 6 parts, Radix Glycyrrhizae, 8 parts of Radix Angelicae Sinensis.
(1) Herba Ecliptae, Herba Cirsii, Auricularia, Nodus Nelumbinis Rhizomatis, Radix Glycyrrhizae powder are broken into 200 order powder, add 3.5 times of water of raw material gross weight, then add 2% cellulase and 1% pectase of raw material gross weight, 43 ℃ of lixiviates 3 hours, filter, collect lixiviating solution, by filtering residue dry for standby;
(2) in standby filtering residue, add 10 times of ethanol of filtering residue gross weight, reflux, extract, 30min, collects extracting solution for the first time; Add 7 times of ethanol of filtering residue gross weight, reflux, extract, 35min, collects extracting solution for the second time again; Add 4 times of ethanol of filtering residue gross weight, reflux, extract, 40min, collects extracting solution for the third time again, merges three times extracting solution, obtains extracting solution, and described ethanol volumetric concentration is 80%, and described three reflux, extract, are all carried out at 45 ℃ of temperature;
(3) lixiviating solution and extracting solution are merged, compression, spraying is dry, makes the Chinese medicine powder for the treatment of gastrorrhagia, and Chinese medicine powder is made to pill.
Embodiment 4
Treat a Chinese medicine for gastrorrhagia, by the raw material of following weight portion, made: 35 parts of Herba Ecliptaes, 25 parts of Herba Cirsiis, 23 parts, Auricularia, 12 parts of Nodus Nelumbinis Rhizomatis, 6 parts, Radix Glycyrrhizae, 9 parts of Radix Angelicae Sinensis.
(1) Herba Ecliptae, Herba Cirsii, Auricularia, Nodus Nelumbinis Rhizomatis, Radix Glycyrrhizae powder are broken into 250 order powder, add 3 times of water of raw material gross weight, then add 2% cellulase and 2% pectase of raw material gross weight, 44 ℃ of lixiviates 3 hours, filter, collect lixiviating solution, by filtering residue dry for standby;
(2) in standby filtering residue, add 11 times of ethanol of filtering residue gross weight, reflux, extract, 35min, collects extracting solution for the first time; Add 8 times of ethanol of filtering residue gross weight, reflux, extract, 30min, collects extracting solution for the second time again; Add 4 times of ethanol of filtering residue gross weight, reflux, extract, 45min, collects extracting solution for the third time again, merges three times extracting solution, obtains extracting solution, and described ethanol volumetric concentration is 85%, and described three reflux, extract, are all carried out at 45 ℃ of temperature;
(3) lixiviating solution and extracting solution are merged, compression, spraying is dry, makes the Chinese medicine powder for the treatment of gastrorrhagia, and Chinese medicine powder is made to pill.
Embodiment 5
Treat a Chinese medicine for gastrorrhagia, by the raw material of following weight portion, made: 45 parts of Herba Ecliptaes, 30 parts of Herba Cirsiis, 30 parts, Auricularia, 15 parts of Nodus Nelumbinis Rhizomatis, 9 parts, Radix Glycyrrhizae, 10 parts of Radix Angelicae Sinensis.
(1) Herba Ecliptae, Herba Cirsii, Auricularia, Nodus Nelumbinis Rhizomatis, Radix Glycyrrhizae powder are broken into 300 order powder, add 4 times of water of raw material gross weight, then add 2% cellulase and 1% pectase of raw material gross weight, 45 ℃ of lixiviates 3 hours, filter, collect lixiviating solution, by filtering residue dry for standby;
(2) in standby filtering residue, add 12 times of ethanol of filtering residue gross weight, reflux, extract, 35min, collects extracting solution for the first time; Add 8 times of ethanol of filtering residue gross weight, reflux, extract, 40min, collects extracting solution for the second time again; Add 5 times of ethanol of filtering residue gross weight, reflux, extract, 45min, collects extracting solution for the third time again, merges three times extracting solution, obtains extracting solution, and described ethanol volumetric concentration is 95%, and described three reflux, extract, are all carried out at 50 ℃ of temperature;
(3) lixiviating solution and extracting solution are merged, compression, spraying is dry, makes the Chinese medicine powder for the treatment of gastrorrhagia, and Chinese medicine powder is made to tablet.
Test example
1, diagnostic criteria:
Originally often have nauseating, stomach discomfort or pain, vomitus is coffee color or kermesinus, haematemesis is measured many persons and is cerise, accompanies error residue more, is mixed with gastric juice, or black stool is pitch shape, the many persons of amount of bleeding can occur Zhi Leng, sweating, increased heart rate and color is pale or faint.
2, physical data:
In January, 2012～2013 year Decembers are diagnosed as patient's 120 examples of gastrorrhagia, in Guilin City institute of traditional Chinese medicine, test.
3, extent of hemorrhage is estimated:
Hyporrhea: ﹤ 500ml/24h, there is dizziness, nervous.
Moderate is hemorrhage: 24h ﹥ 500ml～1000ml, pale complexion, palpitation and short breath.
Severe bleeding: more than 24h ﹥ 1500ml, shock.
4, Therapeutic Method:
120 routine gastrorrhagia patients are divided into 3 groups at random, and every group of 40 people, are respectively 1 group of embodiment, 3 groups of embodiment, contrast groups, wherein in 1 group of embodiment, and severe bleeding 7 examples, hemorrhage 24 examples of moderate, hyporrhea 9 examples; In 3 groups of embodiment, severe bleeding 8 examples, hemorrhage 25 examples of moderate, hyporrhea 7 examples; In contrast groups, severe bleeding 8 examples, hemorrhage 24 examples of moderate, hyporrhea 8 examples.Three groups of cases are in sex, age, the course of disease, and protopathy and the comparison of state of an illness aspect, without significant difference.
1 group of embodiment, gets embodiment 1 tablet 8g, joins 50ml normal saline, oral, every day 3 times; 3 groups of embodiment, get embodiment 3 pill 8g, join 50ml normal saline, oral, every day 3 times; Contrast groups, gives positive kidney brine ice, and norepinephrine 8mg adds in 100ml normal saline, puts into refrigerator cold-storage, makes fluid temperature be chilled to 3 ℃～4 ℃, and minutes 3～4 times/day oral or through Injection by stomach duct.
Within first 3 days, every 2h records mind, blood pressure, heart rate, breathing, borborygmus and vomiting, defecation, urine amount situation, looking into 1 routine blood test, each stool every day all looks into and occults blood, the situation such as itemized record stomachache, dizzy, nervous, feed and complication, adverse effect simultaneously, after stable disease, every day entry is 3 times.
Adopt SPSS11.0 analysis software to process, the efficacy analysis between group adopts Ridit to analyze, enumeration data χ
2check, measurement data is checked with t, all take P<0.05 as significant difference.
5, therapeutic evaluation:
Effective: in 1 week, haematemesis or melena stop, stool color turns yellow, and seldom, hemorrhage simultaneous phenomenon makes moderate progress fecal occult blood, nothing recurrence in a year.
Effective: within 1 week, internal hemorrhage is less, stool color turns yellow, and fecal occult blood is less, and hemorrhage simultaneous phenomenon is slightly improved.
Invalid: through controlling 1 week, hemorrhagely do not subtract, fecal occult blood is without improvement; Severe bleeding, after controlling 24h, without taking a turn for the better, hemorrhage simultaneous phenomenon is without improvement.
6, result of the test:
The result of the test of table 1 embodiment of the present invention 1,3 pairs for the treatment of gastrorrhagias of embodiment
| Group | Number of cases | Effective | Effectively | Invalid | Effective percentage (%) |
| 1 group of embodiment | 40 | 37 | 3 | 0 | 100 |
| 3 groups of embodiment | 40 | 38 | 2 | 0 | 100 |
| Contrast groups | 40 | 22 | 11 | 7 | 82.5 |
The bleeding stopping period of two groups of cases and the comparison of fecal occult blood clearance time: result shows bleeding stopping period and the fecal occult blood clearance time (2.21 ± 0.64d, 3.11 ± 1.12d) of 1 group of embodiment; The bleeding stopping period that embodiment is 3 groups and fecal occult blood clearance time (2.11 ± 0.45d, 3.01 ± 1.09d); Contrast groups (3.78 ± 1.11d, 5.21 ± 1.37d).
As can be seen from Table 1,1 group of embodiment, 3 groups for the treatment of gastrorrhagia effective percentage of embodiment are apparently higher than contrast groups, evident in efficacy.From bleeding stopping period and the comparison of fecal occult blood time, 3 groups of 1 group of embodiment, embodiment are obviously less than contrast groups, illustrate that the Chinese medicine for the treatment of gastrorrhagia of the present invention can obviously shorten bleeding stopping period and fecal occult blood time, determined curative effect.
Claims (6)
1. a Chinese medicine for the treatment of gastrorrhagia, is characterized in that, by the raw material of following weight portion, is made: 25～45 parts of Herba Ecliptaes, 20～30 parts of Herba Cirsiis, 15～30 parts, Auricularia, 5～15 parts of Nodus Nelumbinis Rhizomatis, 2～9 parts, Radix Glycyrrhizae;
The Chinese medicine of described treatment gastrorrhagia, its preparation method comprises the steps:
(1) Herba Ecliptae, Herba Cirsii, Auricularia, Nodus Nelumbinis Rhizomatis, Radix Glycyrrhizae powder are broken into 150～300 order powder, add 3～4 times of water of raw material gross weight, 1%～2% cellulase and 1%～2% pectase that add again raw material gross weight, 40 ℃～45 ℃ lixiviates 2～3 hours, filter, collect lixiviating solution, by filtering residue dry for standby;
(2) in standby filtering residue, add 8～12 times of ethanol of filtering residue gross weight, reflux, extract, 25～35min, collects extracting solution for the first time; Add 5～8 times of ethanol of filtering residue gross weight, reflux, extract, 30～40min, collects extracting solution for the second time again; Add 3～5 times of ethanol of filtering residue gross weight, reflux, extract, 35～45min, collects extracting solution for the third time again, merge three times extracting solution, obtain extracting solution, described ethanol volumetric concentration is 65%～95%, and described three reflux, extract, are all carried out at 40 ℃～50 ℃ temperature;
(3) lixiviating solution and extracting solution are merged, compression, spraying is dry, makes the Chinese medicine powder for the treatment of gastrorrhagia.
2. the Chinese medicine for the treatment of gastrorrhagia according to claim 1, is characterized in that, by the raw material of following weight portion, is made: 30～40 parts of Herba Ecliptaes, 23～27 parts of Herba Cirsiis, 20～25 parts, Auricularia, 10～13 parts of Nodus Nelumbinis Rhizomatis, 5～8 parts, Radix Glycyrrhizae.
3. according to right, want the Chinese medicine of the treatment gastrorrhagia described in 1 or 2, it is characterized in that, by the raw material of following weight portion, made: 35 parts of Herba Ecliptaes, 25 parts of Herba Cirsiis, 23 parts, Auricularia, 12 parts of Nodus Nelumbinis Rhizomatis, 6 parts, Radix Glycyrrhizae.
4. the Chinese medicine for the treatment of gastrorrhagia according to claim 3, is characterized in that: in raw material, also comprise 5～10 parts of Radix Angelicae Sinensis.
5. the Chinese medicine for the treatment of gastrorrhagia according to claim 4, is characterized in that: in raw material, also comprise 8 parts of Radix Angelicae Sinensis.
6. the Chinese medicine for the treatment of gastrorrhagia according to claim 3, is characterized in that: described Chinese medicine powder can be made into tablet or pill.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104958560A (en) * | 2015-07-27 | 2015-10-07 | 郑淑芸 | Traditional Chinese medicine composition for treating upper gastrointestinal bleeding |
| CN106857767A (en) * | 2017-04-28 | 2017-06-20 | 松桃苗族自治县山地生态畜牧业发展中心 | A kind of health care duck cake point and preparation method thereof |
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|---|---|---|---|---|
| CN102210818A (en) * | 2011-05-26 | 2011-10-12 | 辛如才 | Chinese medicine for treating gastrorrhagia |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102210818A (en) * | 2011-05-26 | 2011-10-12 | 辛如才 | Chinese medicine for treating gastrorrhagia |
Non-Patent Citations (1)
| Title |
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| 王建等: "墨旱莲对热盛胃出血止血作用的研究", 《数理医药学杂志》, vol. 18, no. 4, 31 December 2005 (2005-12-31), pages 375 - 376 * |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104958560A (en) * | 2015-07-27 | 2015-10-07 | 郑淑芸 | Traditional Chinese medicine composition for treating upper gastrointestinal bleeding |
| CN106857767A (en) * | 2017-04-28 | 2017-06-20 | 松桃苗族自治县山地生态畜牧业发展中心 | A kind of health care duck cake point and preparation method thereof |
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Effective date of registration: 20221207 Address after: Room 530, B5, Building 19 (No. 699, Chuangxin First Road), Innovation and Entrepreneurship Plaza, Science and Technology Innovation City, Harbin Hi tech Industrial Development Zone, 150000 Heilongjiang Province Patentee after: Harbin haihanfeng Biotechnology Development Co.,Ltd. Address before: Room 602, Unit 1, Building 10, No. 18 Yifeng Road, Qixing District, Guilin City, Guangxi Zhuang Autonomous Region Patentee before: Ma Jian |