CN105168658A - Traditional Chinese medicine preparation for treating stomach cancer and preparation method of traditional Chinese medicine preparation - Google Patents

Abstract

The invention provides a traditional Chinese medicine preparation for treating stomach cancer and a preparation method of the traditional Chinese medicine preparation. The traditional Chinese medicine preparation comprises medicinal raw materials as follows: cuspidat mnium, pig's toenails, camellia japonica, elaeagnus conferta roxb, matteuccia orientalis, roots of eggplants, all-grass of shrotstyle parnassia, a distilled liquid of fleshfingered citron, herb of yellowflower rabdosia, Chinese fir seeds, fudzino grass fern, semen abietis delavayi, angilica polymorpha maxim., pummelo roots, pear leaves, seeds of common sterculia, fruits of tamarind, longan roots and herb of gold stargrass. The traditional Chinese medicine preparation can remarkably improve the symptoms of a patient suffering from stomach cancer, improve the life quality and prolong the lifespan and does not have toxic or side effects.

Description

A kind of Chinese medicine preparation for the treatment of gastric cancer and preparation method thereof

Technical field

The present invention relates to the medicinal preparation containing deriving from plant, animal or mineral component, particularly relating to a kind of Chinese medicine preparation for the treatment of gastric cancer and preparation method thereof.

Background technology

Gastric cancer is alimentary system malignant tumour disease.Comparatively wide at the Area distribution of China's primary disease, be positioned at the first place of various malignant tumor.The most patient's non-evident sympton of early gastric cancer, a few peoples have the digestive symptoms of Nausea and vomiting or similar Peptic Ulcers.Pain is the modal clinical symptoms of advanced gastric carcinoma with losing weight.The digestive symptoms that patient Chang You is comparatively clear and definite, as epigastric discomfort, feed after glutted, along with disease progression Upper abdominal pain increases the weight of, appetite decline, weak.

Western medical treatment is mainly based on operation and chemotherapy, but operation is all not satisfactory with chemotherapeutic efficacy, and operation may cause secondary injury to the patient that health is weak especially.Though chemotherapy has certain curative effect, very big to human injury, there is obvious toxic-side effects.

The definite appellation of motherland's medical science not to gastric cancer, but according to the clinical manifestation of gastric cancer, the category such as " gastric abscess " in Chinese medicine, " dysphagic ", " regurgitation " " feeling of fullness ", " singultus ", " gathering " generally can be belonged to.The etiology and pathogenesis of gastric abscess is mostly relevant to diet, work and rest, the stagnation of QI, cold coagulation etc., therefore " Plain Questions lifts pain opinion " points out: gastric abscess " all because work and rest is exaggerated, intemperance of taking food, deficiency of QI in middle-JIAO, cold-evil avails oneself of the opportunity to get in visitor, therefore suddenly and work greatly bitterly." " Renzhai Zhi Zhi Fang, Effective Recipes from Renzhai House " have recognized that: the cause of disease about gastric abscess mainly contains " have cold, have heat, have dead blood, have food stagnation, have phlegm retention, have worm ".Dysphagic disease, "Nei Jing" thinks relevant with feelings will with body fluid, and Holy Benevolent Prescriptions has done definite description to its cause of disease, thinks that " cold temperature is inappropriate, and overeating, or angry QI rising in reverse order, ponder over sad, cause disorder of YIN and YANG, chest and diaphragm painful abdominal mass plug, and therefore named diaphragm gas also." dysphagicly to be developed by regurgitation, " Longevity and Life Preservation " is said: " husband's regurgitation and dysphagic, dysphagic be regurgitation gradually.Rule for the treatment of has four, blood deficiency, and the deficiency of vital energy has expectorant, has heat.”。

Summary of the invention

Technical problem to be solved by this invention is, provides a kind of Chinese medicine preparation for the treatment of gastric cancer and preparation method thereof, and Chinese medicine preparation of the present invention significantly can improve the symptom of patients with gastric cancer, improves the quality of living, and extend the time-to-live, and toxic and side effects is less.

In order to solve the problems of the technologies described above, the invention provides a kind of Chinese medicine preparation for the treatment of gastric cancer, its raw medicinal material comprises: Mnium cuspidatum Hedw., Unguis Sus domestica, wild camellia, elaeagnus conferta fruits, east Matteuccia strthiopteris, Fructus Solani melongenae root, Herba Parnassiae brevistylae, Liquor Fructus Citri sarcodactylis Distillata, Herba Rabdosiae Sculponeatae, Semen Cunninghamiae Lanceolatae, Vittaria fudzinoi Mak., Semen Abietis Delavayi, turn celery, Radix Citri Grandis, Folium pyri, Semen Sterculiae Nobilis, Fructus Tamarindi Indicae, Radix Longan and Herba hypoxis aureae.

In described Chinese medicine preparation, the ratio of weight and number of each raw medicinal material is as follows: Mnium cuspidatum Hedw. 10 ~ 20 parts, Unguis Sus domestica 5 ~ 15 parts, wild camellia 15 ~ 25 parts, elaeagnus conferta fruits 10 ~ 20 parts, east Matteuccia strthiopteris 10 ~ 20 parts, Fructus Solani melongenae root 20 ~ 30 parts, Herba Parnassiae brevistylae 5 ~ 15 parts, Liquor Fructus Citri sarcodactylis Distillata 10 ~ 20 parts, Herba Rabdosiae Sculponeatae 10 ~ 20 parts, Semen Cunninghamiae Lanceolatae 20 ~ 30 parts, Vittaria fudzinoi Mak. 15 ~ 25 parts, Semen Abietis Delavayi 20 ~ 30 parts, turns celery 10 ~ 20 parts, Radix Citri Grandis 20 ~ 30 parts, Folium pyri 10 ~ 20 parts, Semen Sterculiae Nobilis 12 ~ 22 parts, Fructus Tamarindi Indicae 15 ~ 25 parts, Radix Longan 10 ~ 20 parts and Herba hypoxis aureae 8 ~ 18 parts.

In described Chinese medicine preparation, the ratio of weight and number of each raw medicinal material can be preferably: Mnium cuspidatum Hedw. 15 ~ 20 parts, Unguis Sus domestica 8 ~ 13 parts, wild camellia 18 ~ 23 parts, elaeagnus conferta fruits 12 ~ 17 parts, east Matteuccia strthiopteris 10 ~ 15 parts, Fructus Solani melongenae root 22 ~ 27 parts, Herba Parnassiae brevistylae 8 ~ 13 parts, Liquor Fructus Citri sarcodactylis Distillata 15 ~ 20 parts, Herba Rabdosiae Sculponeatae 13 ~ 18 parts, Semen Cunninghamiae Lanceolatae 25 ~ 30 parts, Vittaria fudzinoi Mak. 17 ~ 22 parts, Semen Abietis Delavayi 20 ~ 25 parts, turn celery 10 ~ 15 parts, Radix Citri Grandis 22 ~ 27 parts, Folium pyri 15 ~ 20 parts, Semen Sterculiae Nobilis 14 ~ 19 parts, Fructus Tamarindi Indicae 18 ~ 23 parts, Radix Longan 12 ~ 17 parts and Herba hypoxis aureae 10 ~ 15 parts.

In described Chinese medicine preparation, the ratio of weight and number of each raw medicinal material also can be preferably: Mnium cuspidatum Hedw. 18 parts, Unguis Sus domestica 10 parts, wild camellia 22 parts, elaeagnus conferta fruits 13 parts, east Matteuccia strthiopteris 14 parts, Fructus Solani melongenae root 22 parts, Herba Parnassiae brevistylae 12 parts, Liquor Fructus Citri sarcodactylis Distillata 15 parts, Herba Rabdosiae Sculponeatae 17 parts, Semen Cunninghamiae Lanceolatae 25 parts, Vittaria fudzinoi Mak. 21 parts, Semen Abietis Delavayi 22 parts, turn celery 14 parts, Radix Citri Grandis 23 parts, Folium pyri 20 parts, Semen Sterculiae Nobilis 15 parts, Fructus Tamarindi Indicae 22 parts, Radix Longan 14 parts and Herba hypoxis aureae 15 parts.

In described Chinese medicine preparation, the ratio of weight and number of each raw medicinal material also can be preferably: Mnium cuspidatum Hedw. 15 parts, Unguis Sus domestica 12 parts, wild camellia 20 parts, elaeagnus conferta fruits 16 parts, east Matteuccia strthiopteris 10 parts, Fructus Solani melongenae root 26 parts, Herba Parnassiae brevistylae 10 parts, Liquor Fructus Citri sarcodactylis Distillata 20 parts, Herba Rabdosiae Sculponeatae 14 parts, Semen Cunninghamiae Lanceolatae 28 parts, Vittaria fudzinoi Mak. 18 parts, Semen Abietis Delavayi 25 parts, turn celery 10 parts, Radix Citri Grandis 25 parts, Folium pyri 16 parts, Semen Sterculiae Nobilis 18 parts, Fructus Tamarindi Indicae 20 parts, Radix Longan 15 parts and Herba hypoxis aureae 10 parts.

Present invention also offers the preparation method of above-mentioned Chinese medicine preparation, the dosage form of described Chinese medicine preparation is capsule, and its preparation method comprises the following steps:

The first step, is mixed in proportion each for described Chinese medicine preparation raw medicinal material, and adding relative to the determining alcohol of mixture quality 2 ~ 4 times is the ethanol of 85 ~ 95%, reflux 1 ~ 3 hour, extracts, and filters acquisition first extracting solution; It is the ethanol of 85 ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 ~ 2 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;

Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 1 ~ 2 hour, pulverize, sieve, obtain 300 order ~ 400 object micropowders;

3rd step, adds Pulvis Talci, magnesium stearate successively in the micropowders that second step obtains, and carries out mixing process, obtains capsule 's content; Described micropowders, magnesium stearate and talcous weight ratio are 100: 0.15 ~ 0.5:0.15 ~ 0.5, incapsulate in housing by described capsule 's content, obtain capsule finished product.

Present invention also offers the preparation method of above-mentioned Chinese medicine preparation, the dosage form of described Chinese medicine preparation is decoction, and its preparation method comprises the following steps:

Step one: purple casserole is put in described raw medicinal material mixing, adds clear water, to clear water dipped medical material upper surface 2-5cm, soak 3-10 hour;

Step 2: purple casserole is placed on fire, after intense fire boils, using slow fire instead, to decoct the 30-50 minute dosage to medicinal liquid be slowly 100-300ml, filters, obtain filtrate a, for subsequent use;

Step 3: residue medicinal residues are added clear water again, to clear water dipped medical material upper surface 2-3cm, soaks 3-10 hour;

Step 4: be placed in by purple casserole on fire, after intense fire boils, using slow fire instead, to decoct the 25-35 minute dosage to medicinal liquid be slowly 100-300ml, filters, obtain filtrate b, mixed by filtrate a and filtrate b.

Beneficial effect of the present invention: Chinese medicine preparation of the present invention significantly can improve the symptom of patients with gastric cancer, improves the quality of living, extends the time-to-live, and has no side effect.

Detailed description of the invention

The invention provides a kind of Chinese medicine preparation for the treatment of gastric cancer, its raw medicinal material comprises: Mnium cuspidatum Hedw., Unguis Sus domestica, wild camellia, elaeagnus conferta fruits, east Matteuccia strthiopteris, Fructus Solani melongenae root, Herba Parnassiae brevistylae, Liquor Fructus Citri sarcodactylis Distillata, Herba Rabdosiae Sculponeatae, Semen Cunninghamiae Lanceolatae, Vittaria fudzinoi Mak., Semen Abietis Delavayi, turn celery, Radix Citri Grandis, Folium pyri, Semen Sterculiae Nobilis, Fructus Tamarindi Indicae, Radix Longan and Herba hypoxis aureae.

In described Chinese medicine preparation, the pharmacology of each raw medicinal material is as follows:

Mnium cuspidatum Hedw.: [another name] Mnium cuspidaum Hedw.[source] medical material Ji Yuan: be the herb of Mniaceae Mnium cuspidaum Hedw.[nature and flavor] are bitter; Light; Cool.[return through] Liver Channel.[function cures mainly] hemostasis removing heat from blood.Main epistaxis; Metrorrhagia; Spit blood; Have blood in stool.[extracts] " China's book on Chinese herbal medicine " " Chinese medicine voluminous dictionary "

Unguis Sus domestica: [another name] pig dewclaw, pig dewclaw first, Ungula Sus domestica zygote, Ungula Sus domestica first, pig move back.[source] medical material Ji Yuan: be the Bauhinia variegata Linn of porcine animals pig.[nature and flavor] salty in the mouth; Cold nature.[return through] stomach; Large intestine channel.[function cures mainly] eliminating phlegm to relieve asthma; Removing toxic substances and promoting granulation.Main cough is panted; Intestinal carbuncle; Anal fistula; The hernia swelling and hanging down of either of the testes; Tinea capitis; Chilblain.[extracts] " China's book on Chinese herbal medicine "

Wild camellia: [another name] Flos Camelliae Japonicae, Flos Camelliae Japonicae, Red Hill Flos Camelliae Japonicae, four rib marks.[source] medical material Ji Yuan: for plant of theaceae southwest Camellia and narrow leaf southwest Camellia flower, leaf, root.[nature and flavor] are micro-pungent; Bitter; Puckery; Flat.[return through] liver; Spleen channel.[function cures mainly] promoting blood circulation and hemostasis; Astringing to arrest diarrhea; Removing toxic substances sore.Main menoxenia; Menorrhagia; Discharging fresh blood stool; Epistaxis; Spit blood; Acute gastroenteritis.[extracts] " China's book on Chinese herbal medicine "

Elaeagnus conferta fruits: [another name] ox louse fruit, sheep mountain miaow tree, sarment Fructus Elaeagni.[source] medical material Ji Yuan: for Elaeangnaceae plant climbs up by holding on to the Herb of Fructus Elaeagni.[nature and flavor] acid; Flat.[function cures mainly] relieving cough and asthma; Antidiarrheal; Hemostasis; Promoting blood circulation and detumescence.Main chronic cough; Asthma; Diarrhoea; Spit blood; Spitting of blood; Jaundice; Rheumatic arthralgia; Traumatic injury congestive edema; Laryngopharynx swelling and pain.[extracts] " China's book on Chinese herbal medicine "

East Matteuccia strthiopteris: [another name] great Ye Herba pteridii latiusculi, Malaysia bar.[source] medical material Ji Yuan: be rhizome or the stem and leaf of ball Pteridiaceae plant east Matteuccia strthiopteris.[nature and flavor] are bitter; Cool.[function cures mainly] dispels the wind; Hemostasis.Main air pain of dampness syndrome; Traumatic hemorrhage.[extracts] " China's book on Chinese herbal medicine "

Fructus Solani melongenae root: [another name] Radix Solani Melongenae.The root of the white eggplant of [source] Solanaceae nightshade.Autumn uproots, and removing fibrous root and impurity, section is dried.[nature and flavor] are sweet, cool.[function cures mainly] clearing away heat-damp and promoting diuresis, dispelling wind stopping cough, astringing to arrest bleeding.For rheumatic arthritis, senile chronic tracheitis, edema, chronic cough, chronic dysentery, leucorrhea, seminal emission, hematuria, has blood in stool; External treating chilblain.[extracts] " national Chinese herbal medicine compilation "

Herba Parnassiae brevistylae: [source] medical material Ji Yuan: be the herb of dicotyledon medicine saxifragaceae plant Herba Parnassiae brevistylae.[nature and flavor] are bitter; Cool.[return through] enters lung, stomach two warp.[function cures mainly] heat-clearing and toxic substances removing; Cooling blood for hemostasis.Main heating; Hemorrhage due to internal injury.[extracts] " China's book on Chinese herbal medicine "

Liquor Fructus Citri sarcodactylis Distillata: [source] medical material Ji Yuan: be the distillate of the fruit of rutaceae Fructus Citri Sarcodactylis.[nature and flavor] are micro-pungent; Light; Property is put down.[return through] lung; Liver; Stomach; Kidney channel.[function cures mainly] promoting QI circulation for relieving depression.Main chest and diaphragm is gloomy not to relax.[extracts] " China's book on Chinese herbal medicine "

Herba Rabdosiae Sculponeatae: [another name] dysentery medicine, square-stem Folium Perillae, Herba Stachydis Japonicae, false Herba Urticae Cannabinae, rotten foot grass, smelly Herba Artemisiae.[source] medical material Ji Yuan: be the herb of labiate Hemerocallis citrina Baroni Herba Rabdosiae glaucocalycis.[nature and flavor] acrid in the mouth; Warm in nature.[function cures mainly] regulates the flow of vital energy; Dampness removing; Removing toxic substances.Main dysentery stomachache; Tinea pedis.[extracts] " China's book on Chinese herbal medicine "

Semen Cunninghamiae Lanceolatae: [another name] Cunninghamia lanceolata (Lamb.) Hook..[source] medical material Ji Yuan: be the seed of taxodiaceae plant Lignum seu Ramulus Cunninghamiae Lanceolatae.[nature and flavor] are pungent; Slightly warm in nature.[function cures mainly] regulates the flow of vital energy cold expelling; Pain relieving.Main hernia pain.[extracts] " China's book on Chinese herbal medicine "

Vittaria fudzinoi Mak.: [another name] Herba Poae Sphondylodis, Fructus Fici Pumilae gold, Drymotaenium miyoshianum (Mak.) Mak..[source] medical material Ji Yuan: be the herb of the flat rib Herba Vittariae Flexuosae of Vittariaceae plant.[nature and flavor] tepor; Micro-hardship; Nontoxic.[return through] liver; Stomach warp.[function cures mainly] regulates the flow of vital energy; Invigorate blood circulation; Pain relieving.Main traumatic injury; Bones and muscles pain; Impairment caused by overstrain pain; Peratodynia; Infantile convulsion; Infantile malnutrition; Corneal nebula; An emaciation due to blood disorder.[extracts] " China's book on Chinese herbal medicine " " Chinese medicine voluminous dictionary "

Semen Abietis Delavayi: [source] medical material Ji Yuan: be the seed of pinaceae plant Abies delavayi.[nature and flavor] are pungent; Warm in nature.Regulate the flow of vital energy during [function cures mainly] is wet; Dispersing cold for relieving pain.Main sun stroke pain due to disorder of QI; Gastral cavity abdomen; Cold type of pain, colicky.[extracts] " China's book on Chinese herbal medicine "

Turn celery: [another name] Radix Pternopetali vulgaris.[source] medical material Ji Yuan: for samphire turns the root of celery.[nature and flavor] acrid in the mouth; Warm in nature.[function cures mainly] is delivered and is dispeled the wind; Warming spleen and stomach for dispelling cold; Regulating QI to relieve pain.Main exterior syndrome due to wind-cold; Pathogenic wind-warm arthralgia pain; Gastral cavity abdomen; Pain in chest and hypochondrium; Traumatic injury.[extracts] " China's book on Chinese herbal medicine "

Radix Citri Grandis: [another name] Citrus chachiensis Hort. root, Fructus Citri junoris tree root.[source] medical material Ji Yuan: be the tree root of Citrus paradisi Macfadyen.[nature and flavor] are pungent; Bitter; Temperature.[return through] lung; Stomach; Liver Channel.[function cures mainly] regulating QI to relieve pain; Dispersing wind and cold.Main stomachache flatulence; Hernia pain; Cough due to wind and cold.[extracts] " China's book on Chinese herbal medicine "

Folium pyri: [source] medical material Ji Yuan: be the leaf of medicine rosaceous plant Pyrus bretschneideri, Nashi Pear or Pyrus ussuriensis Maxim etc.[nature and flavor] are bitter, puckery, Xin Liang.[return through] lung; Spleen; Urinary bladder channel.[function cures mainly] soothing liver-QI stomach function regulating, promoting diuresis to remove toxic substance.Main cholera is vomited and diarrhoea and is suffered from abdominal pain, and edema, dysuria, infantile hernia, mushroom is poisoning.[extracts] " China's book on Chinese herbal medicine "

Semen Sterculiae Nobilis: [another name] tamarindus indica L., Ping Poguo, Semen Sterculiae Nobilis, Pan Anguo, seven elder sister fruits, rich and honour son, false Semen Sterculiae Nobilis, Folium Styracis Suberifoliae fruit.[source] medical material Ji Yuan: be the seed of Sterculiaceae plant sterculia nobilis.[nature and flavor] are sweet; Flat.[return through] stomach; Large intestine; Small intestine meridian.[function cures mainly] stomach function regulating helps digestion, removing toxic substances parasite killing.Main regurgitation of food from the stomach tells food; Abdominal pain due to worm stagnation; Colic; The rotten head infections of children's.[extracts] " China's book on Chinese herbal medicine "

Fructus Tamarindi Indicae: [another name] sour dumpling, dark plum, Man Mu, Radix seu Caulis Kadsurae Heteroclitae.[source] medical material Ji Yuan: be the fruit of leguminous plant tamarind.[nature and flavor] sweet acid; Cool.[return through] heart; Stomach warp.[function cures mainly] clearing away summer-heat; Stomach function regulating removing food stagnancy.Main heatstroke; Inappetence; Infantile malnutrition; Vomiting during pregnancy; Constipation [extracts] " China's book on Chinese herbal medicine "

Radix Longan: [source] medical material Ji Yuan: be root or the root bark of sapindaceous plant Arillus Longan.[nature and flavor] are bitter; Puckery; Flat.[return through] large intestine channel.[function cures mainly] eliminating damp-heat; Change and turbidly exempt from numbness.Main chyluria; Leucorrhea; Erysipelas; Damp and hot arthralgia pain.[extracts] " China's book on Chinese herbal medicine "

Herba hypoxis aureae: [another name] little Rhizoma Curculiginis, little Jin lock prunus mume (sieb.) sieb.et zucc., Herba Allii bulleyani, imperial kidney, unipods Rhizoma Curculiginis.[source] medical material Ji Yuan: be the Herb of bloodwort Herba hypoxis aureae.[nature and flavor] are sweet, micro-pungent, warm.[function cures mainly] warming the kidney to invigorate YANG; Regulating QI to relieve pain.Main lumbago due to renal deficiency; Sexual impotence; Insomnia; Colic of cold type is suffered from abdominal pain.[extracts] " China's book on Chinese herbal medicine "

In described Chinese medicine preparation, the ratio of weight and number of each raw medicinal material is as follows: Mnium cuspidatum Hedw. 10 ~ 20 parts, Unguis Sus domestica 5 ~ 15 parts, wild camellia 15 ~ 25 parts, elaeagnus conferta fruits 10 ~ 20 parts, east Matteuccia strthiopteris 10 ~ 20 parts, Fructus Solani melongenae root 20 ~ 30 parts, Herba Parnassiae brevistylae 5 ~ 15 parts, Liquor Fructus Citri sarcodactylis Distillata 10 ~ 20 parts, Herba Rabdosiae Sculponeatae 10 ~ 20 parts, Semen Cunninghamiae Lanceolatae 20 ~ 30 parts, Vittaria fudzinoi Mak. 15 ~ 25 parts, Semen Abietis Delavayi 20 ~ 30 parts, turns celery 10 ~ 20 parts, Radix Citri Grandis 20 ~ 30 parts, Folium pyri 10 ~ 20 parts, Semen Sterculiae Nobilis 12 ~ 22 parts, Fructus Tamarindi Indicae 15 ~ 25 parts, Radix Longan 10 ~ 20 parts and Herba hypoxis aureae 8 ~ 18 parts.

In described Chinese medicine preparation, the ratio of weight and number of each raw medicinal material can be preferably: Mnium cuspidatum Hedw. 15 ~ 20 parts, Unguis Sus domestica 8 ~ 13 parts, wild camellia 18 ~ 23 parts, elaeagnus conferta fruits 12 ~ 17 parts, east Matteuccia strthiopteris 10 ~ 15 parts, Fructus Solani melongenae root 22 ~ 27 parts, Herba Parnassiae brevistylae 8 ~ 13 parts, Liquor Fructus Citri sarcodactylis Distillata 15 ~ 20 parts, Herba Rabdosiae Sculponeatae 13 ~ 18 parts, Semen Cunninghamiae Lanceolatae 25 ~ 30 parts, Vittaria fudzinoi Mak. 17 ~ 22 parts, Semen Abietis Delavayi 20 ~ 25 parts, turn celery 10 ~ 15 parts, Radix Citri Grandis 22 ~ 27 parts, Folium pyri 15 ~ 20 parts, Semen Sterculiae Nobilis 14 ~ 19 parts, Fructus Tamarindi Indicae 18 ~ 23 parts, Radix Longan 12 ~ 17 parts and Herba hypoxis aureae 10 ~ 15 parts.

In described Chinese medicine preparation, the ratio of weight and number of each raw medicinal material also can be preferably: Mnium cuspidatum Hedw. 18 parts, Unguis Sus domestica 10 parts, wild camellia 22 parts, elaeagnus conferta fruits 13 parts, east Matteuccia strthiopteris 14 parts, Fructus Solani melongenae root 22 parts, Herba Parnassiae brevistylae 12 parts, Liquor Fructus Citri sarcodactylis Distillata 15 parts, Herba Rabdosiae Sculponeatae 17 parts, Semen Cunninghamiae Lanceolatae 25 parts, Vittaria fudzinoi Mak. 21 parts, Semen Abietis Delavayi 22 parts, turn celery 14 parts, Radix Citri Grandis 23 parts, Folium pyri 20 parts, Semen Sterculiae Nobilis 15 parts, Fructus Tamarindi Indicae 22 parts, Radix Longan 14 parts and Herba hypoxis aureae 15 parts.

In described Chinese medicine preparation, the ratio of weight and number of each raw medicinal material also can be preferably: Mnium cuspidatum Hedw. 15 parts, Unguis Sus domestica 12 parts, wild camellia 20 parts, elaeagnus conferta fruits 16 parts, east Matteuccia strthiopteris 10 parts, Fructus Solani melongenae root 26 parts, Herba Parnassiae brevistylae 10 parts, Liquor Fructus Citri sarcodactylis Distillata 20 parts, Herba Rabdosiae Sculponeatae 14 parts, Semen Cunninghamiae Lanceolatae 28 parts, Vittaria fudzinoi Mak. 18 parts, Semen Abietis Delavayi 25 parts, turn celery 10 parts, Radix Citri Grandis 25 parts, Folium pyri 16 parts, Semen Sterculiae Nobilis 18 parts, Fructus Tamarindi Indicae 20 parts, Radix Longan 15 parts and Herba hypoxis aureae 10 parts.

Present invention also offers the preparation method of above-mentioned Chinese medicine preparation, the dosage form of described Chinese medicine preparation is capsule, and its preparation method comprises the following steps:

The first step, is mixed in proportion each for described Chinese medicine preparation raw medicinal material, and adding relative to the determining alcohol of mixture quality 2 ~ 4 times is the ethanol of 85 ~ 95%, reflux 1 ~ 3 hour, extracts, and filters acquisition first extracting solution; It is the ethanol of 85 ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 ~ 2 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;

Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 1 ~ 2 hour, pulverize, sieve, obtain 300 order ~ 400 object micropowders;

3rd step, adds Pulvis Talci, magnesium stearate successively in the micropowders that second step obtains, and carries out mixing process, obtains capsule 's content; Described micropowders, magnesium stearate and talcous weight ratio are 100: 0.15 ~ 0.5:0.15 ~ 0.5, incapsulate in housing by described capsule 's content, obtain capsule finished product.

Present invention also offers the preparation method of above-mentioned Chinese medicine preparation, the dosage form of described Chinese medicine preparation is decoction, and its preparation method comprises the following steps:

Step one: purple casserole is put in described raw medicinal material mixing, adds clear water, to clear water dipped medical material upper surface 2-5cm, soak 3-10 hour;

Step 2: purple casserole is placed on fire, after intense fire boils, using slow fire instead, to decoct the 30-50 minute dosage to medicinal liquid be slowly 100-300ml, filters, obtain filtrate a, for subsequent use;

Step 3: residue medicinal residues are added clear water again, to clear water dipped medical material upper surface 2-3cm, soaks 3-10 hour;

Step 4: be placed in by purple casserole on fire, after intense fire boils, using slow fire instead, to decoct the 25-35 minute dosage to medicinal liquid be slowly 100-300ml, filters, obtain filtrate b, mixed by filtrate a and filtrate b.

Below adopt embodiment to describe embodiments of the present invention in detail, fully understand how application technology means solve technical problem in the present invention whereby, reach technique effect and implement according to this.

Embodiment 1: capsule

Get Mnium cuspidatum Hedw. 150g, Unguis Sus domestica 120g, wild camellia 200g, elaeagnus conferta fruits 160g, east Matteuccia strthiopteris 100g, Fructus Solani melongenae root 260g, Herba Parnassiae brevistylae 100g, Liquor Fructus Citri sarcodactylis Distillata 200g, Herba Rabdosiae Sculponeatae 140g, Semen Cunninghamiae Lanceolatae 280g, Vittaria fudzinoi Mak. 180g, Semen Abietis Delavayi 250g, turn celery 100g, Radix Citri Grandis 250g, Folium pyri 160g, Semen Sterculiae Nobilis 180g, Fructus Tamarindi Indicae 200g, Radix Longan 150g and Herba hypoxis aureae 100g;

Prepare according to the following steps:

The first step, is mixed in proportion each for described Chinese medicine preparation raw medicinal material, and adding relative to the determining alcohol of mixture quality 4 times is the ethanol of 95%, reflux 2 hours, extracts, and filters acquisition first extracting solution; It is the ethanol of 85% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 2 times again, reflux 2 hours, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;

Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 1 hour, pulverize, sieve, obtain 400 object micropowders;

3rd step, adds Pulvis Talci, magnesium stearate successively in the micropowders that second step obtains, and carries out mixing process, obtains capsule 's content; Described micropowders, magnesium stearate and talcous weight ratio are 100: 0.2:0.3, incapsulate in housing by described capsule 's content, obtain capsule finished product.

Embodiment 2: decoction

Get Mnium cuspidatum Hedw. 18g, Unguis Sus domestica 10g, wild camellia 22g, elaeagnus conferta fruits 13g, east Matteuccia strthiopteris 14g, Fructus Solani melongenae root 22g, Herba Parnassiae brevistylae 12g, Liquor Fructus Citri sarcodactylis Distillata 15g, Herba Rabdosiae Sculponeatae 17g, Semen Cunninghamiae Lanceolatae 25g, Vittaria fudzinoi Mak. 21g, Semen Abietis Delavayi 22g, turn celery 14g, Radix Citri Grandis 23g, Folium pyri 20g, Semen Sterculiae Nobilis 15g, Fructus Tamarindi Indicae 22g, Radix Longan 14g and Herba hypoxis aureae 15g;

Prepare according to the following steps:

Step one: purple casserole is put in described raw medicinal material mixing, adds clear water, to clear water dipped medical material upper surface 4cm, soak 7 hours;

Step 2: purple casserole is placed on fire, after intense fire boils, using slow fire instead, to decoct the 40 minutes dosage to medicinal liquid be slowly 200ml, filters, obtain filtrate a, for subsequent use;

Step 3: residue medicinal residues are added clear water again, to clear water dipped medical material upper surface 2.5cm, soaks 5 hours;

Step 4: be placed in by purple casserole on fire, after intense fire boils, using slow fire instead, to decoct the 30 minutes dosage to medicinal liquid be slowly 200ml, filters, obtain filtrate b, mixed by filtrate a and filtrate b.

Toxicity test:

Acute toxicity testing: application mice 60, male and female half and half, body weight 20 ~ 30g, carries out acute toxicity test.Mice is divided into two groups at random, i.e. matched group and administration group, fasting 12 hours before experiment, the Traditional Chinese medicine preparation capsule agent prepared by embodiments of the invention 1 is dissolved in water, (concentration is 7.42g crude drug/ml, maximum concentration) gavage, gavage volume is 5ml/kg (namely unit dosage form is 37.1 crude drugs/kg), matched group gives normal saline, administration in one day 2 times, delivery time 6 hours, Continuous Observation 14 days after administration, and record mice toxic reaction and death toll.Experimental result shows: compare with matched group, and after administration, mice has no notable difference, and experiment Continuous Observation 14 days, mouse systemic situation, diet, drinking-water, body weight increase all normal.Mouse oral gavage capsule LD50>37.1 crude drug/kg of the present invention, every day, maximum dosage-feeding was 74.2 crude drugs/kg/ day.Chinese medicine preparation clinical application amount of the present invention be 7.5g crude drug/day/people, adult body weight in 60KG, average dosage is 0.125g crude drug/kg/ day.By weighing machine: the dosis tolerata of mice (average weight is in 25g) oral administration gavage Chinese medicine preparation of the present invention is 596 times of quantity.Therefore Chinese medicine preparation acute toxicity of the present invention is extremely low, clinical drug safety.

Long term toxicity test: Chinese medicine preparation embodiment 1 capsule of the present invention to three groups of mices (often organize 20) by 13.82, 19.32 and 38.14g crude drug/kg continuous use 15 weeks (1.0ml/100g body weight, every day 2 times) and drug withdrawal after 3 weeks, result shows: Chinese medicine preparation of the present invention is to the hair of mice, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, the indexs such as blood fat all have no significant effect, internal organs naked eyes do not find that difference change and histological indications show, medication 15 weeks and drug withdrawal are after 3 weeks, Organs of Mice is all without obviously changing.Illustrate that Chinese medicine preparation of the present invention is little to toxicity after mice long-term prescription, also there is no difference reaction after drug withdrawal, application safety.

Clinical data:

Case selection: whole 110 routine patients are all diagnosed as gastric cancer through fibergastroscope and histopathological examination.Wherein male 64 people, women 46 people, 36 ~ 74 years old age.Press TNM method, wherein II phase 33 example, III phase 48 example, IV phase 29 example by stages.Wherein adenocarcinoma ulcerative 23 example, adenocarcinoma infiltrating 21 example, papillary adenocarcinoma 17 example, poorly differentiated adenocarcinoma 23 example, print army cell carcinoma 11 example, adenocarcinoma,mucoid 15 example.

Be divided into treatment group and matched group at random.Wherein, treatment group 55 people, male 33 people, women 22 people, 36 ~ 74 years old age; II phase 17 example, III phase 24 example, IV phase 14 example; Wherein adenocarcinoma ulcerative 12 example, adenocarcinoma infiltrating 11 example, papillary adenocarcinoma 8 example, poorly differentiated adenocarcinoma 12 example, print army cell carcinoma 5 example, adenocarcinoma,mucoid 7 example.Matched group 55 people, male 31 people, women 24 people, 38 ~ 74 years old age; II phase 16 example, III phase 24 example, IV phase 15 example; Wherein adenocarcinoma ulcerative 11 example, adenocarcinoma infiltrating 10 example, papillary adenocarcinoma 9 example, poorly differentiated adenocarcinoma 11 example, print army cell carcinoma 6 example, adenocarcinoma,mucoid 8 example.Two groups at equal not statistically significants of comparing difference (p>0.05) such as age, sex, clinical stages, symptom and pathologicals.

Diagnostic criteria: with reference to People's Republic of China's health industry standard (ws316-2010) diagnosing gastric cancer standard: (1) symptom: gastric cancer lacks specific clinical symptoms; Early gastric cancer is often asymptomatic, epigastric discomfort or pain, loss of appetite, become thin, weak, Nausea and vomiting, hematemesis or melena, diarrhoea, constipation, heating, abdominal part occur that the symptoms such as lump likely appear at the different phase in gastric cancer generation evolution, but all without specificity.(2) sign: gastric cancer lacks specificity sign; Early gastric cancer often without obvious sign, late gastric cancer or likely there is epigastrium lump when there is metastasis focus, rectum front touches the sign such as swollen thing, supraclavicular lymph nodes enlargement.(3) fibergastroscopy: the sensitivity of fibergastroscopy diagnosis of gastric cancer is high, can the position of accurate positioning tumor by fibergastroscopy, can obtain tissue specimen to complete pathological biopsy simultaneously.Nearly all patient being diagnosed as gastric cancer through upper digestive tract contrast examination needs to accept fibergastroscopy and pathological biopsy to make a definite diagnosis again.Therefore, gastroscope should be directly selected to replace upper digestive tract radiography as the first-selected inspection method of diagnosis of gastric cancer.(4) upper digestive tract radiography: upper digestive tract contrast examination safety, noinvasive, without the need to calm and be widely used.But for gastric cancer (particularly early gastric cancer) diagnostic sensitivity lower than fibergastroscopy.Should can not carry out the medical institutions of fibergastroscopy or select as the inspection method of diagnosing gastric cancer gastroscopic patient cannot be tolerated.(5) histodiagnosis: histopathologic diagnosis is the determination diagnosis basis of gastric cancer, before the various oncotherapy means of enforcement, should obtain pathological diagnosis foundation as far as possible.(6) computed tomographic venography (CT): computed tomographic venography has value evaluating in the extent of disease of gastric cancer, metastases in local lymph node situation and metastasis situation etc., should as the first-selected inspection method of preoperative staging of gastric carcinoma.(7) diagnose: the diagnosis of gastric cancer cannot rely on merely the clinical data such as medical history, sings and symptoms to be established.Conventional method such as application upper digestive tract radiography and fibergastroscopy etc. establishes the clinical diagnosis of gastric cancer clinically, should using the latter as the prefered method diagnosed.Gastric cancer make a definite diagnosis according to being histopathological examination result.

Therapeutic Method:

Treatment group: give the embodiment of the present invention 1 capsule every day 3 times, each 3.30 days was 1 course for the treatment of, took 6 months continuously.

Matched group: according to state of an illness needs, select Combination chemotherapy, scheme used is: FOLFOX4 scheme (L-OHP85mg/m2, intravenous drip 2h, first day; CF200mg/m2, intravenous drip 2h, the 2nd, 3 days; 5-FU400mg/m2, intravenous injection, the 2nd, 3 days; 5-FU600mg/m2, continues quiet note 22h, the 2nd, 3 days), medication is undertaken by above order, and every 2 weeks repeat, and 30 days is one-period, is used in conjunction 6 cycles, to be suited the medicine to the illness after chemotherapeutic period and chemotherapy Supporting Therapy, as vein gives injection omeprazole, tropisetron injection etc.

Efficacy assessment standard: record tumor size before and after treatment, B ultrasonic, CT examination result; All patients routine examination blood, urine, stool routine, hepatic and renal function and electrocardiogram, reaction is observed in therapeutic process, efficacy evaluation is according to RECIST solid tumor the standard of curative effect evaluation: complete incidence graph (CR): all foci disappearances, occur without new focus, tumor markers is down to normally, and at least maintains 4 weeks; Partial rcsponse (PR): the most major diameter sum of tumor reduces >=and more than 30%, and at least maintain 4 weeks; Pathological changes stablizes (SD): tumor maximum diameter sum reduces and do not reach PR, or increase does not reach PD; Lesion growth (PD): maximum diameter increases >=20%, or occurs new focus; But former focus division is not very interior.Be effectively (RR) with CR+PR.

Observational technique: mid-term effects to observe the symptoms after 6 months alleviation situation, life quality in treatment, Patients after Chemotherapy detects after 3 weeks at end of chemotherapy; Late result mainly carries out the investigation of life span.

Remission status: gastric cancer often occurs fatigue and asthenia, lustreless complexion, loss of appetite, defecate uncomfortable, glutted after food, the symptoms such as nausea and vomiting, score in various degree according to these Symptoms, and calculating integral value, after treatment, symptom average product score value is improvement than more than 1/3 person that declines before treatment.

Life quality: evaluating with physical situation scoring kamofsky standard, improving 10 points more than for improving, declines 10 points below for decline, treat front and back change be less than 10 be divided into constant.

Therapeutic outcome: treat after 6 months, result is shown in form below respectively.

Two groups of Comparison of therapeutic situations after 6 months treated by table 1:

Group	n	CR	PR	SD	PD	RR (effective percentage)
							Treatment group	55	8	31	14	2	39(70.9％)
Matched group	55	3	23	21	8	26(47.3％)

Table 2 is treated two groups of remission status after 6 months and is compared:

Note: in table 2, number of cases is for alleviating number of cases/symptom number of cases.

Table 3 is treated two groups of life quality situations of change after 6 months and is compared (example (%)):

Group	n	Rise	Stable	Decline
					Treatment group	55	22(40％)	26(47.27％)	7(12.72％)
Matched group	55	16(29.09％)	24(43.64％)	15(27.27％)

Survival rate: in 110 routine patients, 83 examples wherein can be kept in touch by phone or network mode and patient household or sufferers themselves, and follow the tracks of and follow up a case by regular visits to 5 years half, wherein treatment group 43 example, matched group 40 example, statistical data is in table 4.

A table 4 liang group survival rate compares (example (%)):

Group	n	> 1 year	> 3 years	> 5 years
					Treatment group	43	37(86.04％)	28(65.12％)	17(39.53％)
Matched group	40	27(67.5％)	15(37.5％)	10(25％)

Concrete case: high mountain, women, 57 years old.Because of Upper abdominal pain, become thin, the symptoms such as hematemesis, are brought to examination in hospital by household, are diagnosed as gastric cancer through fibergastroscope and histopathological examination, belong to papillary adenocarcinoma III phase.Give Chinese medicine preparation embodiment 1 capsule of the present invention every day 3 times, each 3, treat after 6 months, symptom complete incidence graph, life quality significantly improves, existence 4 years 3 months after treatment.

The above is only preferred embodiment of the present invention, and be not restriction the present invention being made to other form, any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the Equivalent embodiments of equivalent variations.But everyly do not depart from technical solution of the present invention content, any simple modification, equivalent variations and the remodeling done above embodiment according to technical spirit of the present invention, still belong to the protection domain of technical solution of the present invention.

Claims (9)

1. treat a Chinese medicine preparation for gastric cancer, it is characterized in that, each raw medicinal material of described Chinese medicine preparation comprises: Mnium cuspidatum Hedw., Unguis Sus domestica, wild camellia, elaeagnus conferta fruits, east Matteuccia strthiopteris, Fructus Solani melongenae root, Herba Parnassiae brevistylae, Liquor Fructus Citri sarcodactylis Distillata, Herba Rabdosiae Sculponeatae, Semen Cunninghamiae Lanceolatae, Vittaria fudzinoi Mak., Semen Abietis Delavayi, turn celery, Radix Citri Grandis, Folium pyri, Semen Sterculiae Nobilis, Fructus Tamarindi Indicae, Radix Longan and Herba hypoxis aureae.

2. Chinese medicine preparation as claimed in claim 1, it is characterized in that, the ratio of weight and number of each raw medicinal material of described Chinese medicine preparation is as follows: Mnium cuspidatum Hedw. 10 ~ 20 parts, Unguis Sus domestica 5 ~ 15 parts, wild camellia 15 ~ 25 parts, elaeagnus conferta fruits 10 ~ 20 parts, east Matteuccia strthiopteris 10 ~ 20 parts, Fructus Solani melongenae root 20 ~ 30 parts, Herba Parnassiae brevistylae 5 ~ 15 parts, Liquor Fructus Citri sarcodactylis Distillata 10 ~ 20 parts, Herba Rabdosiae Sculponeatae 10 ~ 20 parts, Semen Cunninghamiae Lanceolatae 20 ~ 30 parts, Vittaria fudzinoi Mak. 15 ~ 25 parts, Semen Abietis Delavayi 20 ~ 30 parts, turn celery 10 ~ 20 parts, Radix Citri Grandis 20 ~ 30 parts, Folium pyri 10 ~ 20 parts, Semen Sterculiae Nobilis 12 ~ 22 parts, Fructus Tamarindi Indicae 15 ~ 25 parts, Radix Longan 10 ~ 20 parts and Herba hypoxis aureae 8 ~ 18 parts.

3. Chinese medicine preparation as claimed in claim 1 or 2, it is characterized in that, the ratio of weight and number of each raw medicinal material of described Chinese medicine preparation is as follows: Mnium cuspidatum Hedw. 15 ~ 20 parts, Unguis Sus domestica 8 ~ 13 parts, wild camellia 18 ~ 23 parts, elaeagnus conferta fruits 12 ~ 17 parts, east Matteuccia strthiopteris 10 ~ 15 parts, Fructus Solani melongenae root 22 ~ 27 parts, Herba Parnassiae brevistylae 8 ~ 13 parts, Liquor Fructus Citri sarcodactylis Distillata 15 ~ 20 parts, Herba Rabdosiae Sculponeatae 13 ~ 18 parts, Semen Cunninghamiae Lanceolatae 25 ~ 30 parts, Vittaria fudzinoi Mak. 17 ~ 22 parts, Semen Abietis Delavayi 20 ~ 25 parts, turn celery 10 ~ 15 parts, Radix Citri Grandis 22 ~ 27 parts, Folium pyri 15 ~ 20 parts, Semen Sterculiae Nobilis 14 ~ 19 parts, Fructus Tamarindi Indicae 18 ~ 23 parts, Radix Longan 12 ~ 17 parts and Herba hypoxis aureae 10 ~ 15 parts.

4. the Chinese medicine preparation as described in claims 1 to 3, is characterized in that, the ratio of weight and number of each raw medicinal material of described Chinese medicine preparation is as follows: Mnium cuspidatum Hedw. 18 parts, Unguis Sus domestica 10 parts, wild camellia 22 parts, elaeagnus conferta fruits 13 parts, east Matteuccia strthiopteris 14 parts, Fructus Solani melongenae root 22 parts, Herba Parnassiae brevistylae 12 parts, Liquor Fructus Citri sarcodactylis Distillata 15 parts, Herba Rabdosiae Sculponeatae 17 parts, Semen Cunninghamiae Lanceolatae 25 parts, Vittaria fudzinoi Mak. 21 parts, Semen Abietis Delavayi 22 parts, turn celery 14 parts, Radix Citri Grandis 23 parts, Folium pyri 20 parts, Semen Sterculiae Nobilis 15 parts, Fructus Tamarindi Indicae 22 parts, Radix Longan 14 parts and Herba hypoxis aureae 15 parts.

5. the Chinese medicine preparation as described in claims 1 to 3, is characterized in that, the ratio of weight and number of each raw medicinal material of described Chinese medicine preparation is as follows: Mnium cuspidatum Hedw. 15 parts, Unguis Sus domestica 12 parts, wild camellia 20 parts, elaeagnus conferta fruits 16 parts, east Matteuccia strthiopteris 10 parts, Fructus Solani melongenae root 26 parts, Herba Parnassiae brevistylae 10 parts, Liquor Fructus Citri sarcodactylis Distillata 20 parts, Herba Rabdosiae Sculponeatae 14 parts, Semen Cunninghamiae Lanceolatae 28 parts, Vittaria fudzinoi Mak. 18 parts, Semen Abietis Delavayi 25 parts, turn celery 10 parts, Radix Citri Grandis 25 parts, Folium pyri 16 parts, Semen Sterculiae Nobilis 18 parts, Fructus Tamarindi Indicae 20 parts, Radix Longan 15 parts and Herba hypoxis aureae 10 parts.

6. the Chinese medicine preparation as described in claim 1 to 5, is characterized in that, the dosage form of described Chinese medicine preparation is capsule, and its preparation method comprises the following steps:

The first step, is mixed in proportion each for described Chinese medicine preparation raw medicinal material, and adding relative to the determining alcohol of mixture quality 2 ~ 4 times is the ethanol of 85 ~ 95%, reflux 1 ~ 3 hour, extracts, and filters acquisition first extracting solution; It is the ethanol of 85 ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 ~ 2 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;

Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 1 ~ 2 hour, pulverize, sieve, obtain 300 order ~ 400 object micropowders;

3rd step, adds Pulvis Talci, magnesium stearate successively in the micropowders that second step obtains, and carries out mixing process, obtains capsule 's content; Described micropowders, magnesium stearate and talcous weight ratio are 100: 0.15 ~ 0.5:0.15 ~ 0.5, incapsulate in housing by described capsule 's content, obtain capsule finished product.

7. the Chinese medicine preparation as described in claim 1 to 5, is characterized in that, the dosage form of described Chinese medicine preparation is decoction, and its preparation method comprises the following steps:

Step one: purple casserole is put in described raw medicinal material mixing, adds clear water, to clear water dipped medical material upper surface 2-5cm, soak 3-10 hour;

Step 2: purple casserole is placed on fire, after intense fire boils, using slow fire instead, to decoct the 30-50 minute dosage to medicinal liquid be slowly 100-300ml, filters, obtain filtrate a, for subsequent use;

Step 3: residue medicinal residues are added clear water again, to clear water dipped medical material upper surface 2-3cm, soaks 3-10 hour;

Step 4: be placed in by purple casserole on fire, after intense fire boils, using slow fire instead, to decoct the 25-35 minute dosage to medicinal liquid be slowly 100-300ml, filters, obtain filtrate b, mixed by filtrate a and filtrate b.

8. a preparation method for Chinese medicine preparation described in claim 1 to 5, is characterized in that, the dosage form of described Chinese medicine preparation is capsule, and its preparation method comprises the following steps:

The first step, is mixed in proportion each for described Chinese medicine preparation raw medicinal material, and adding relative to the determining alcohol of mixture quality 2 ~ 4 times is the ethanol of 85 ~ 95%, reflux 1 ~ 3 hour, extracts, and filters acquisition first extracting solution; It is the ethanol of 85 ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 ~ 2 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;

Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 1 ~ 2 hour, pulverize, sieve, obtain 300 order ~ 400 object micropowders;

3rd step, adds Pulvis Talci, magnesium stearate successively in the micropowders that second step obtains, and carries out mixing process, obtains capsule 's content; Described micropowders, magnesium stearate and talcous weight ratio are 100: 0.15 ~ 0.5:0.15 ~ 0.5, incapsulate in housing by described capsule 's content, obtain capsule finished product.

9. a preparation method for Chinese medicine preparation described in claim 1 to 5, is characterized in that, the dosage form of described Chinese medicine preparation is decoction, and its preparation method comprises the following steps:

Step one: purple casserole is put in described raw medicinal material mixing, adds clear water, to clear water dipped medical material upper surface 2-5cm, soak 3-10 hour;

Step 2: purple casserole is placed on fire, after intense fire boils, using slow fire instead, to decoct the 30-50 minute dosage to medicinal liquid be slowly 100-300ml, filters, obtain filtrate a, for subsequent use;

Step 3: residue medicinal residues are added clear water again, to clear water dipped medical material upper surface 2-3cm, soaks 3-10 hour;

Step 4: be placed in by purple casserole on fire, after intense fire boils, using slow fire instead, to decoct the 25-35 minute dosage to medicinal liquid be slowly 100-300ml, filters, obtain filtrate b, mixed by filtrate a and filtrate b.