CN103599237B - Traditional Chinese medicine for treating gastric cancer of stasis in stomach collateral type and preparation method thereof - Google Patents
Traditional Chinese medicine for treating gastric cancer of stasis in stomach collateral type and preparation method thereof Download PDFInfo
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Abstract
The invention provides a traditional Chinese medicine for treating gastric cancer of stasis in stomach collateral type and a preparation method thereof. The traditional Chinese medicine comprises the following bulk drugs: sarcococca ruscifolia, desmos chinensis, peperomia dindygulensis, fomes fomentarius, scutellaria barbata, sarcandra glabra, brittle falsepimpernel herb, semen impatientis, kadsura coccinea, ixora chinensis root, clematis aethusifolia, tylophora yunnanensis rhizome and aristolochia impressinervis. The traditional Chinese medicine is capable of activating blood, resolving stasis, freeing collateral vessels, relieving pain, softening hardness, dispersing accumulation, substantially improving the symptom of blood stasis stomach collateral type gastric cancer patients, improving life quality and prolonging survival time, and is relatively small in toxic and side effects.
Description
Technical field
The present invention relates to the medicinal preparation containing deriving from plant, animal or mineral component, particularly relating to and a kind ofly treating Chinese medicine of stasis blocking stomach network type gastric cancer and preparation method thereof.
Background technology
Gastric cancer is alimentary system malignant tumour disease.Comparatively wide at the Area distribution of China's primary disease, be positioned at the first place of various malignant tumor.The most patient's non-evident sympton of early gastric cancer, a few peoples have the digestive symptoms of Nausea and vomiting or similar Peptic Ulcers.Pain is the modal clinical symptoms of advanced gastric carcinoma with losing weight.The digestive symptoms that patient Chang You is comparatively clear and definite, as epigastric discomfort, feed after glutted, along with disease progression Upper abdominal pain increases the weight of, appetite decline, weak.
Western medical treatment is mainly based on operation and chemotherapy, but operation is all not satisfactory with chemotherapeutic efficacy, and operation may cause secondary injury to the patient that health is weak especially.Though chemotherapy has certain curative effect, very big to human injury, there is obvious toxic-side effects.
The definite appellation of motherland's medical science not to gastric cancer, but according to the clinical manifestation of gastric cancer, the category such as " gastric abscess " in Chinese medicine, " dysphagic ", " regurgitation " " feeling of fullness ", " singultus ", " gathering " generally can be belonged to.The etiology and pathogenesis of gastric abscess is mostly relevant to diet, work and rest, the stagnation of QI, cold coagulation etc., therefore " Plain Questions lifts pain opinion " points out: gastric abscess " all because work and rest is exaggerated, intemperance of taking food, deficiency of QI in middle-JIAO, cold-evil avails oneself of the opportunity to get in visitor, therefore suddenly and work greatly bitterly." " Renzhai Zhi Zhi Fang, Effective Recipes from Renzhai House " have recognized that: the cause of disease about gastric abscess mainly contains " have cold, have heat, have dead blood, have food stagnation, have phlegm retention, have worm ".Dysphagic disease, "Nei Jing" thinks relevant with feelings will with body fluid, and Holy Benevolent Prescriptions has done definite description to its cause of disease, thinks that " cold temperature is inappropriate, and overeating, or angry QI rising in reverse order, ponder over sad, cause disorder of YIN and YANG, chest and diaphragm painful abdominal mass plug, and therefore named diaphragm gas also." dysphagicly to be developed by regurgitation, " Longevity and Life Preservation " is said: " husband's regurgitation and dysphagic, dysphagic be regurgitation gradually.Rule for the treatment of has four, blood deficiency, and the deficiency of vital energy has expectorant, has heat." gastric cancer typing is by Chinese medicine: (1) due to weakness of spleen and stomach; (2) liver-stomach disharmony type; (3) stasis blocking stomach network type; (4) gastric heat YIN-deficiency type; (5) phlegm-damp stagnation type; (6) QIXUELIANGXU type six type.
Summary of the invention
Technical problem to be solved by this invention is, there is provided a kind of and treat Chinese medicine of stasis blocking stomach network type gastric cancer and preparation method thereof, Chinese medicine blood circulation promoting and blood stasis dispelling of the present invention, removing obstruction in the collateral to relieve pain, softening the hard mass removing food stagnancy, significantly can improve the symptom of stasis blocking stomach network type patients with gastric cancer, improve the quality of living, extend the time-to-live, and toxic and side effects is less.
In order to solve the problems of the technologies described above, the invention provides a kind of Chinese medicine for the treatment of stasis blocking stomach network type gastric cancer, its raw medicinal material comprises: Radix Sarcococcae Ruscifoliae (Herba Sarcoclccae Ruscifoliae), Folium desmoris, Herba Peperomiae Dindygulensis, Fomes Fomentarius, Herba Scutellariae Barbatae, Herba Pileae Scriptae, Herba Linderniae Crustaceae, Semen Impatientis, Caulis Kadsurae Coccineae, Radix Ixorae Chinensis, Clematis aethusifolia Turcz, Radix Tylophorae Yunnanensis and wear stone rattan.
In described Chinese medicine, the ratio of weight and number of each raw medicinal material is as follows: Radix Sarcococcae Ruscifoliae (Herba Sarcoclccae Ruscifoliae) 15 ~ 25 parts, Folium desmoris 10 ~ 20 parts, Herba Peperomiae Dindygulensis 20 ~ 30 parts, Fomes Fomentarius 30 ~ 40 parts, Herba Scutellariae Barbatae 5 ~ 15 parts, Herba Pileae Scriptae 10 ~ 20 parts, Herba Linderniae Crustaceae 30 ~ 40 parts, Semen Impatientis 15 ~ 25 parts, Caulis Kadsurae Coccineae 20 ~ 30 parts, Radix Ixorae Chinensis 5 ~ 15 parts, Clematis aethusifolia Turcz 5 ~ 15 parts, Radix Tylophorae Yunnanensis 10 ~ 20 parts and wear 15 ~ 25 parts, stone rattan.
In described Chinese medicine, the ratio of weight and number of each raw medicinal material can be preferably: Radix Sarcococcae Ruscifoliae (Herba Sarcoclccae Ruscifoliae) 15 ~ 20 parts, Folium desmoris 10 ~ 15 parts, Herba Peperomiae Dindygulensis 20 ~ 25 parts, Fomes Fomentarius 30 ~ 35 parts, Herba Scutellariae Barbatae 5 ~ 10 parts, Herba Pileae Scriptae 10 ~ 15 parts, Herba Linderniae Crustaceae 30 ~ 35 parts, Semen Impatientis 15 ~ 20 parts, Caulis Kadsurae Coccineae 20 ~ 25 parts, Radix Ixorae Chinensis 5 ~ 10 parts, Clematis aethusifolia Turcz 5 ~ 10 parts, Radix Tylophorae Yunnanensis 10 ~ 15 parts and wear 15 ~ 20 parts, stone rattan.
In described Chinese medicine, the ratio of weight and number of each raw medicinal material also can be preferably: Radix Sarcococcae Ruscifoliae (Herba Sarcoclccae Ruscifoliae) 16 parts, Folium desmoris 12 parts, Herba Peperomiae Dindygulensis 24 parts, Fomes Fomentarius 33 parts, Herba Scutellariae Barbatae 6 parts, Herba Pileae Scriptae 12 parts, Herba Linderniae Crustaceae 31 parts, Semen Impatientis 17 parts, Caulis Kadsurae Coccineae 23 parts, Radix Ixorae Chinensis 7 parts, Clematis aethusifolia Turcz 7 parts, Radix Tylophorae Yunnanensis 14 parts and wear 16 parts, stone rattan.
In described Chinese medicine, the ratio of weight and number of each raw medicinal material also can be preferably: Radix Sarcococcae Ruscifoliae (Herba Sarcoclccae Ruscifoliae) 18 parts, Folium desmoris 13 parts, Herba Peperomiae Dindygulensis 22 parts, Fomes Fomentarius 31 parts, Herba Scutellariae Barbatae 7 parts, Herba Pileae Scriptae 14 parts, Herba Linderniae Crustaceae 34 parts, Semen Impatientis 18 parts, Caulis Kadsurae Coccineae 21 parts, Radix Ixorae Chinensis 8 parts, Clematis aethusifolia Turcz 6 parts, Radix Tylophorae Yunnanensis 12 parts and wear 18 parts, stone rattan.
Present invention also offers the preparation method of above-mentioned Chinese medicine, the dosage form of described Chinese medicine is capsule, and its preparation method comprises the following steps:
The first step: each for described Chinese medicine raw medicinal material is mixed in proportion, adding relative to the determining alcohol of mixture quality 2 ~ 3 times is the ethanol of 80 ~ 90%, reflux 2 ~ 3 hours, extracts, and filters acquisition first extracting solution; It is the ethanol of 80 ~ 90% that the medicinal residues that filtration obtains add relative to the determining alcohol of medicinal residues quality 1 ~ 2 times again, reflux 1 ~ 2 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;
Second step: the dry cream that the first step obtains is placed in super micron mill and pulverizes 1 ~ 3 hour, pulverize and sieve acquisition 100 ~ 300 object micropowders;
3rd step: the micropowders obtained at second step adds relative to the microcrystalline Cellulose of its quality 0.2 ~ 0.3 times, the starch of 0.1 ~ 0.2 times, the magnesium stearate of 0.01 ~ 0.02 times, carry out mixing process, namely capsule 's content is obtained, described Capsule content is incapsulated in housing, namely obtains capsule finished product.
Present invention also offers the preparation method of above-mentioned Chinese medicine, the dosage form of described Chinese medicine is oral liquid, and its preparation method comprises the following steps:
The first step: described raw medicinal material is mixed, add relative to mixture 3 times ~ 5 times amount determining alcohol be 55% ~ 65% alcohol reflux 2 times ~ 4 times, each 2 hours ~ 3 hours, filter, filtrate merges, and reclaims ethanol, being concentrated into 70 DEG C of relative densities is the mastic of 1.30 ~ 1.32, for subsequent use;
Second step: described mastic 55 DEG C ~ 65 DEG C reduced vacuum dryings that the first step is obtained, get dry extract powder;
3rd step: is added ethanol in the described dried cream powder that second step is obtained, obtains containing alcohol mastic, and the described alcohol content containing alcohol mastic is 65% ~ 70%; Carry out chilling treatment, precipitation process, filtration treatment, recovery Ethanol Treatment by described successively containing alcohol mastic, obtain dealcoholysis mastic, wherein, the chilling treatment time is 30 ~ 40 hours;
4th step: add cane sugar powder, active carbon by described dealcoholysis mastic, carry out heat treated, filtration treatment, dilution process successively, obtain semi-finished product; The weight ratio of described dealcoholysis mastic and described cane sugar powder is 1: 0.1 ~ 0.3; The weight ratio of described dealcoholysis mastic and described active carbon is 1: 0.001 ~ 0.002; The time of described heat treated is 20 ~ 40 minutes, and temperature is 100 DEG C ~ 110 DEG C;
5th step: the more described semi-finished product that the 4th step obtains are carried out filtration treatment, embedding process, sterilization treatment successively, obtain described Chinese medicine oral liquid finished product.
Beneficial effect of the present invention: Chinese medicine blood circulation promoting and blood stasis dispelling of the present invention, removing obstruction in the collateral to relieve pain, softening the hard mass removing food stagnancy, significantly can improve the symptom of stasis blocking stomach network type patients with gastric cancer, improve the quality of living, and extend the time-to-live, and toxic and side effects is less.
Detailed description of the invention
The invention provides and a kind ofly treat Chinese medicine of stasis blocking stomach network type gastric cancer and preparation method thereof, its raw medicinal material comprises: Radix Sarcococcae Ruscifoliae (Herba Sarcoclccae Ruscifoliae), Folium desmoris, Herba Peperomiae Dindygulensis, Fomes Fomentarius, Herba Scutellariae Barbatae, Herba Pileae Scriptae, Herba Linderniae Crustaceae, Semen Impatientis, Caulis Kadsurae Coccineae, Radix Ixorae Chinensis, Clematis aethusifolia Turcz, Radix Tylophorae Yunnanensis and wear stone rattan.
In above-mentioned Chinese medicine, the pharmacology of each raw medicinal material is as follows:
Radix Sarcococcae Ruscifoliae (Herba Sarcoclccae Ruscifoliae): pungent is bitter, flat.Return liver, stomach warp.Promoting flow of QI and blood; Wind-expelling pain-stopping.Main gastralgia, anemofrigid-damp arthralgia, traumatic injury." Yunnan Chinese herbal medicine ": active, pain relieving.Treat for stomachache, traumatic injury.
Folium desmoris: bitter, pungent, temperature.Return spleen, Liver Channel.Expelling wind and removing dampness, blood-activating analgetic, invigorating the spleen and regulating the stomach, preventing the attack (or recurrence) of malaria parasite killing.Main rheumatic ostalgia, malaria, edema, traumatic injury, rubella, scabies, rotten foot.
Herba Peperomiae Dindygulensis: pungent is cool.Return spleen, stomach, liver, kidney channel.Heat-clearing and toxic substances removing, blood stasis-eliminating and stagnation-dissipating, inducing diuresis to remove edema.Main lung-heat cough with asthma, measles, sore, cancerous protuberance, burn and scald, traumatic injury, oedema due to nephritis." choosing of Yunnan Chinese herbal medicine ": eliminating stasis and resolving masses, anticancer.Control gastric cancer, esophageal carcinoma, hepatocarcinoma, breast carcinoma, pulmonary carcinoma.
Fomes Fomentarius: micro-hardship, property is put down.Removing food stagnancy, blood stasis dispelling, anticancer.Staple food amasss, the esophageal carcinoma, gastric cancer, uterus carcinoma.
Herba Scutellariae Barbatae: acrid in the mouth, bitter, cold in nature.Return lung, liver, kidney channel.Heat-clearing and toxic substances removing, dissipating blood stasis stops blooding, inducing diuresis to remove edema, analgesic therapy.Control haematemesis, epistaxis, stranguria with blood, bloody dysentery, jaundice, have sore throat, lung abscess, furuncle, scrofula, sore, cancerous protuberance, traumatic injury knife injury, venom." Quanzhou book on Chinese herbal medicine ": heat clearing away, removing toxic substances, dispels the wind, loose blood, circulation of qi promoting, diuretic, dredging collateral, removing blood stasis with potent drugs, pain relieving.Main stranguria with blood for oral administration, spits blood, epistaxis; Venom is controlled in external, carbuncle, furuncle, innominate toxic swelling.
Herba Pileae Scriptae: pungent, flat.Anti-inflammation, expelling wind and removing dampness, promoting blood circulation and stopping pain.Control pneumonia, acute appendicitis, acute gastroenteritis, bacillary dysentery, rheumatalgia, traumatic injury, fracture." east, Fujian book on Chinese herbal medicine ": spleen invigorating, invigorates blood circulation, quenches the thirst, subside a swelling swollen.Diseases caused by exogenous pathogenic factor after managing property. alternate attack of chill and fever, head-body-pain, thirsty, swelling.
Herba Linderniae Crustaceae: micro-hardship, light, cool.Clearing away heat-damp and promoting diuresis, promoting blood circulation and stopping pain.Main anemopyretic cold, damp-heat dysentery, oedema due to nephritis, leucorrhea, menoxenia, carbuncle furuncle and phyma poison, venom, traumatic injury." register planted by Guangxi medicine ": control traumatic injury, acute mastitis, gastric cancer.
Semen Impatientis: micro-hardship, pungent, temperature.Return spleen, Liver Channel.Relieve internal heat anticancer, scattered silt detumescence.Removing blood stasis softening the hard mass, removing food stagnancy.For mass in the abdomen, amenorrhea, dysphagic.
Caulis Kadsurae Coccineae: pungent, micro-hardship, warm in nature.Promoting the circulation of QI to relieve pain, dissipating blood stasis dredging collateral.For gastric and duodenal ulcers, chronic gastritis, acute gastroenteritis, rheumatic arthralgia, traumatic injury, fracture, dysmenorrhea, postnatal blood stasis is suffered from abdominal pain, colicky." Chinese Plants will ": root is medicinal, energy promoting flow of QI and blood, reducing swelling and alleviating pain, controls gastropathy, rheumatic ostalgia, traumatic injury stasis of blood pain, and is gynecological's common medicine.
Radix Ixorae Chinensis: bitter, micro-puckery, cool.Return lung, stomach warp.Clearing away heat and cooling blood, promoting blood circulation and stopping pain.Main cough, hemoptysis, rheumatic arthritis, stomachache, women's amenorrhea, skin infection swells and ache, traumatic injury.
Clematis aethusifolia Turcz: pungent, temperature.Return liver, stomach warp.Dispelling wind and removing obstruction in the collateral, pain relieving, invigorating the stomach and promoting digestion, parasite killing.Main air pain of dampness syndrome, dyspepsia, vomiting, cysticercosis, eczema scrotum, sore and toxic.
Radix Tylophorae Yunnanensis: micro-hardship, pungent, warm in nature.Return liver, spleen channel.Channels sootheing and network vessel quickening, promoting blood circulation and stopping pain.Dispelling the wind and dampness pathogens osteodynia, hepatitis, gastric ulcer, poliomyelitis sequela, traumatic injury." Yunnan Chinese herbal medicine ": relaxing muscles and tendons to promote blood circulation, menstruction regulating and pain relieving.Control traumatic injury, rheumatic ostalgia, hepatitis, gastric ulcer, chronic consumptive disease, pernicious malaria.
Wear stone rattan: bitter, pungent, temperature.Return liver, stomach, large intestine channel.Dispelling wind and removing obstruction in the collateral, promoting blood circulation and stopping pain.Dispelling the wind and dampness pathogens arthralgia pain, stomachache, traumatic injury pain caused by ecchymoma, enteritis, poliomyelitis sequela.
In described Chinese medicine, the ratio of weight and number of each raw medicinal material is as follows: Radix Sarcococcae Ruscifoliae (Herba Sarcoclccae Ruscifoliae) 15 ~ 25 parts, Folium desmoris 10 ~ 20 parts, Herba Peperomiae Dindygulensis 20 ~ 30 parts, Fomes Fomentarius 30 ~ 40 parts, Herba Scutellariae Barbatae 5 ~ 15 parts, Herba Pileae Scriptae 10 ~ 20 parts, Herba Linderniae Crustaceae 30 ~ 40 parts, Semen Impatientis 15 ~ 25 parts, Caulis Kadsurae Coccineae 20 ~ 30 parts, Radix Ixorae Chinensis 5 ~ 15 parts, Clematis aethusifolia Turcz 5 ~ 15 parts, Radix Tylophorae Yunnanensis 10 ~ 20 parts and wear 15 ~ 25 parts, stone rattan.
In described Chinese medicine, the ratio of weight and number of each raw medicinal material can be preferably: Radix Sarcococcae Ruscifoliae (Herba Sarcoclccae Ruscifoliae) 15 ~ 20 parts, Folium desmoris 10 ~ 15 parts, Herba Peperomiae Dindygulensis 20 ~ 25 parts, Fomes Fomentarius 30 ~ 35 parts, Herba Scutellariae Barbatae 5 ~ 10 parts, Herba Pileae Scriptae 10 ~ 15 parts, Herba Linderniae Crustaceae 30 ~ 35 parts, Semen Impatientis 15 ~ 20 parts, Caulis Kadsurae Coccineae 20 ~ 25 parts, Radix Ixorae Chinensis 5 ~ 10 parts, Clematis aethusifolia Turcz 5 ~ 10 parts, Radix Tylophorae Yunnanensis 10 ~ 15 parts and wear 15 ~ 20 parts, stone rattan.
In described Chinese medicine, the ratio of weight and number of each raw medicinal material also can be preferably: Radix Sarcococcae Ruscifoliae (Herba Sarcoclccae Ruscifoliae) 16 parts, Folium desmoris 12 parts, Herba Peperomiae Dindygulensis 24 parts, Fomes Fomentarius 33 parts, Herba Scutellariae Barbatae 6 parts, Herba Pileae Scriptae 12 parts, Herba Linderniae Crustaceae 31 parts, Semen Impatientis 17 parts, Caulis Kadsurae Coccineae 23 parts, Radix Ixorae Chinensis 7 parts, Clematis aethusifolia Turcz 7 parts, Radix Tylophorae Yunnanensis 14 parts and wear 16 parts, stone rattan.
In described Chinese medicine, the ratio of weight and number of each raw medicinal material also can be preferably: Radix Sarcococcae Ruscifoliae (Herba Sarcoclccae Ruscifoliae) 18 parts, Folium desmoris 13 parts, Herba Peperomiae Dindygulensis 22 parts, Fomes Fomentarius 31 parts, Herba Scutellariae Barbatae 7 parts, Herba Pileae Scriptae 14 parts, Herba Linderniae Crustaceae 34 parts, Semen Impatientis 18 parts, Caulis Kadsurae Coccineae 21 parts, Radix Ixorae Chinensis 8 parts, Clematis aethusifolia Turcz 6 parts, Radix Tylophorae Yunnanensis 12 parts and wear 18 parts, stone rattan.
Present invention also offers the preparation method of above-mentioned Chinese medicine, the dosage form of described Chinese medicine is capsule, and its preparation method comprises the following steps:
The first step: each for described Chinese medicine raw medicinal material is mixed in proportion, adding relative to the determining alcohol of mixture quality 2 ~ 3 times is the ethanol of 80 ~ 90%, reflux 2 ~ 3 hours, extracts, and filters acquisition first extracting solution; It is the ethanol of 80 ~ 90% that the medicinal residues that filtration obtains add relative to the determining alcohol of medicinal residues quality 1 ~ 2 times again, reflux 1 ~ 2 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;
Second step: the dry cream that the first step obtains is placed in super micron mill and pulverizes 1 ~ 3 hour, pulverize and sieve acquisition 100 ~ 300 object micropowders;
3rd step: the micropowders obtained at second step adds relative to the microcrystalline Cellulose of its quality 0.2 ~ 0.3 times, the starch of 0.1 ~ 0.2 times, the magnesium stearate of 0.01 ~ 0.02 times, carry out mixing process, namely capsule 's content is obtained, described Capsule content is incapsulated in housing, namely obtains capsule finished product.
Present invention also offers the preparation method of above-mentioned Chinese medicine, the dosage form of described Chinese medicine is oral liquid, and its preparation method comprises the following steps:
The first step: described raw medicinal material is mixed, add relative to mixture 3 times ~ 5 times amount determining alcohol be 55% ~ 65% alcohol reflux 2 times ~ 4 times, each 2 hours ~ 3 hours, filter, filtrate merges, and reclaims ethanol, being concentrated into 70 DEG C of relative densities is the mastic of 1.30 ~ 1.32, for subsequent use;
Second step: the described mastic mixing that the first step is obtained, 55 DEG C ~ 65 DEG C reduced vacuum dryings, get dry extract powder;
3rd step: is added ethanol in the described dried cream powder that second step is obtained, obtains containing alcohol mastic, and the described alcohol content containing alcohol mastic is 65% ~ 70%; Carry out chilling treatment, precipitation process, filtration treatment, recovery Ethanol Treatment by described successively containing alcohol mastic, obtain dealcoholysis mastic, wherein, the chilling treatment time is 30 ~ 40 hours;
4th step: add cane sugar powder, active carbon by described dealcoholysis mastic, carry out heat treated, filtration treatment, dilution process successively, obtain semi-finished product; The weight ratio of described dealcoholysis mastic and described cane sugar powder is 1: 0.1 ~ 0.3; The weight ratio of described dealcoholysis mastic and described active carbon is 1: 0.001 ~ 0.002; The time of described heat treated is 20 ~ 40 minutes, and temperature is 100 DEG C ~ 110 DEG C;
5th step: the more described semi-finished product that the 4th step obtains are carried out filtration treatment, embedding process, sterilization treatment successively, obtain described Chinese medicine oral liquid finished product.
Below adopt embodiment to describe embodiments of the present invention in detail, fully understand how application technology means solve technical problem in the present invention whereby, reach technique effect and implement according to this.
Embodiment 1: capsule
Get Radix Sarcococcae Ruscifoliae (Herba Sarcoclccae Ruscifoliae) 160g, Folium desmoris 120g, Herba Peperomiae Dindygulensis 240g, Fomes Fomentarius 330g, Herba Scutellariae Barbatae 60g, Herba Pileae Scriptae 120g, Herba Linderniae Crustaceae 310g, Semen Impatientis 170g, Caulis Kadsurae Coccineae 230g, Radix Ixorae Chinensis 70g, Clematis aethusifolia Turcz 70g, Radix Tylophorae Yunnanensis 140g and wear stone rattan 160g;
Prepare according to the following steps:
The first step: each for described Chinese medicine raw medicinal material is mixed in proportion, adding relative to the determining alcohol of mixture quality 3 times is the ethanol of 80%, reflux 2 hours, extracts, and filters acquisition first extracting solution; It is the ethanol of 80% that the medicinal residues that filtration obtains add relative to the determining alcohol of medicinal residues quality 2 times again, reflux 1 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;
Second step: the dry cream that the first step obtains is placed in super micron mill and pulverizes 2 hours, pulverize and sieve acquisition 200 object micropowders;
3rd step: the micropowders obtained at second step adds relative to the microcrystalline Cellulose of its quality 0.3 times, the starch of 0.2 times, the magnesium stearate of 0.01 times, carry out mixing process, namely obtain capsule 's content, described Capsule content is incapsulated in housing, namely obtain capsule finished product.
Embodiment 2: oral liquid
Get Radix Sarcococcae Ruscifoliae (Herba Sarcoclccae Ruscifoliae) 180g, Folium desmoris 130g, Herba Peperomiae Dindygulensis 220g, Fomes Fomentarius 310g, Herba Scutellariae Barbatae 70g, Herba Pileae Scriptae 140g, Herba Linderniae Crustaceae 340g, Semen Impatientis 180g, Caulis Kadsurae Coccineae 210g, Radix Ixorae Chinensis 80g, Clematis aethusifolia Turcz 60g, Radix Tylophorae Yunnanensis 120g and wear stone rattan 180g;
Prepare according to the following steps:
The first step: described raw medicinal material is mixed, add relative to mixture 5 times amount determining alcohol be 65% alcohol reflux 3 times, each 2 hours, filter, filtrate merges, and reclaim ethanol, being concentrated into 70 DEG C of relative densities is the mastic of 1.30, for subsequent use;
Second step: the described mastic that the first step is obtained, 65 DEG C of reduced vacuum dryings, get dry extract powder;
3rd step: is added ethanol in the described dried cream powder that second step is obtained, obtains containing alcohol mastic, and the described alcohol content containing alcohol mastic is 70%; Carry out chilling treatment, precipitation process, filtration treatment, recovery Ethanol Treatment by described successively containing alcohol mastic, obtain dealcoholysis mastic, wherein, the chilling treatment time is 30 hours;
4th step: add cane sugar powder, active carbon by described dealcoholysis mastic, carry out heat treated, filtration treatment, dilution process successively, obtain semi-finished product; The weight ratio of described dealcoholysis mastic and described cane sugar powder is 1: 0.2; The weight ratio of described dealcoholysis mastic and described active carbon is 1: 0.001; The time of described heat treated is 30 minutes, and temperature is 100 DEG C;
5th step: the more described semi-finished product that the 4th step obtains are carried out filtration treatment, embedding process, sterilization treatment successively, obtain described Chinese medicine oral liquid finished product.
Toxicity test:
Acute toxicity testing: application mice 60, male and female half and half, body weight 28 ~ 38g, carries out acute toxicity test.Mice is divided into two groups at random, i.e. matched group and administration group, before experiment, fasting 12 hours, is dissolved in water by Chinese medicine capsules prepared by embodiments of the invention 1, (concentration is 7.46g crude drug/ml, maximum concentration) gavage, gavage volume is 5ml/kg(and unit dosage form is 37.3 crude drugs/kg), matched group gives normal saline, administration in one day 2 times, delivery time 6 hours, Continuous Observation 14 days after administration, and record mice toxic reaction and death toll.Experimental result shows: compare with matched group, and after administration, mice has no notable difference, and experiment Continuous Observation 14 days, mouse systemic situation, diet, drinking-water, body weight increase all normal.Mouse oral gavage tablet of the present invention and LD50>37.3 crude drug/kg, every day, maximum dosage-feeding was 74.6 crude drugs/kg/ day.Chinese medicine clinical application amount of the present invention be 7.8g crude drug/day/people, adult body weight in 60KG, average dosage is 0.13g crude drug/kg/ day.By weighing machine: the dosis tolerata of mice (average weight is in 33g) oral administration gavage Chinese medicine of the present invention is 574 times of quantity.Therefore Chinese medicine acute toxicity of the present invention is extremely low, clinical drug safety.
Long term toxicity test: Chinese medicine embodiment 1 capsule of the present invention presses 13.43,19.25 and 38.32g crude drug/kg continuous use 15 weeks (1.0ml/100g body weight to mice, every day 2 times) and drug withdrawal after 3 weeks, result shows: the index such as hair, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat of Chinese medicine of the present invention to mice all has no significant effect, internal organs naked eyes do not find that difference change and histological indications show, medication 15 weeks and drug withdrawal are after 3 weeks, and Organs of Mice is all without obviously changing.Illustrate that Chinese medicine of the present invention is little to toxicity after mice long-term prescription, also there is no difference reaction after drug withdrawal, application safety.
Clinical data:
Case selection: whole 68 routine cases are all diagnosed as gastric cancer through fibergastroscope and histopathological examination, then through Syndrome Types of TCM be stasis blocking stomach network type gastric cancer.Wherein male 46 people, women 22 people, 37 ~ 79 years old age.Press TNM method, wherein II phase 10 example, III phase 34 example, IV phase 24 example by stages.Wherein adenocarcinoma ulcerative 16 example, adenocarcinoma infiltrating 19 example, papillary adenocarcinoma 3 example, poorly differentiated adenocarcinoma 15 example, print army cell carcinoma 2 example, adenocarcinoma,mucoid 13 example.
Be divided into treatment group and matched group at random, wherein treatment group 34 people, male 23 people, women 11 people, 38 ~ 79 years old age.II phase 5 example, III phase 18 example, IV phase 11 example.Wherein adenocarcinoma ulcerative 8 example, adenocarcinoma infiltrating 10 example, papillary adenocarcinoma 2 example, poorly differentiated adenocarcinoma 7 example, print army cell carcinoma 1 example, adenocarcinoma,mucoid 6 example; Matched group 34 people, male 23 people, women 11 people, 37 ~ 79 years old age.II phase 5 example, III phase 16 example, IV phase 13 example.Wherein adenocarcinoma ulcerative 8 example, adenocarcinoma infiltrating 9 example, papillary adenocarcinoma 1 example, poorly differentiated adenocarcinoma 8 example, print army cell carcinoma 1 example, adenocarcinoma,mucoid 7 example.Two groups at equal not statistically significants of comparing difference (p>0.05) such as age, sex, clinical stages, symptom and pathologicals.
Then diagnostic criteria: be gastric cancer by following Western medicine diagnose standard diagnostics is stasis blocking stomach network type gastric cancer by the further typing of following tcm diagnosis standard.
Western medicine diagnose standard: with reference to People's Republic of China's health industry standard (ws316-2010) diagnosing gastric cancer standard: (1) symptom: gastric cancer lacks specific clinical symptoms; Early gastric cancer is often asymptomatic, epigastric discomfort or pain, loss of appetite, become thin, weak, Nausea and vomiting, hematemesis or melena, diarrhoea, constipation, heating, abdominal part occur that the symptoms such as lump likely appear at the different phase in gastric cancer generation evolution, but all without specificity.(2) sign: gastric cancer lacks specificity sign; Early gastric cancer often without obvious sign, late gastric cancer or likely there is epigastrium lump when there is metastasis focus, rectum front touches the sign such as swollen thing, supraclavicular lymph nodes enlargement.(3) fibergastroscopy: the sensitivity of fibergastroscopy diagnosis of gastric cancer is high, can the position of accurate positioning tumor by fibergastroscopy, can obtain tissue specimen to complete pathological biopsy simultaneously.Nearly all patient being diagnosed as gastric cancer through upper digestive tract contrast examination needs to accept fibergastroscopy and pathological biopsy to make a definite diagnosis again.Therefore, gastroscope should be directly selected to replace upper digestive tract radiography as the first-selected inspection method of diagnosis of gastric cancer.(4) upper digestive tract radiography: upper digestive tract contrast examination safety, noinvasive, without the need to calm and be widely used.But for gastric cancer (particularly early gastric cancer) diagnostic sensitivity lower than fibergastroscopy.Should can not carry out the medical institutions of fibergastroscopy or select as the inspection method of diagnosing gastric cancer gastroscopic patient cannot be tolerated.(5) histodiagnosis: histopathologic diagnosis is the determination diagnosis basis of gastric cancer, before the various oncotherapy means of enforcement, should obtain pathological diagnosis foundation as far as possible.(6) computed tomographic venography (CT): computed tomographic venography has value evaluating in the extent of disease of gastric cancer, metastases in local lymph node situation and metastasis situation etc., should as the first-selected inspection method of preoperative staging of gastric carcinoma.(7) diagnose: the diagnosis of gastric cancer cannot rely on merely the clinical data such as medical history, sings and symptoms to be established.Conventional method such as application upper digestive tract radiography and fibergastroscopy etc. establishes the clinical diagnosis of gastric cancer clinically, should using the latter as the prefered method diagnosed.Gastric cancer make a definite diagnosis according to being histopathological examination result.
Syndrome Differentiation of Traditional Chinese Medicine standard: the Standards of Chinese Medical Syndrome Differentiation in the combination of Chinese and Western medicine diagnosis and treatment project of the gastric cancer formulated with reference to digestive system disease Professional Committee of CAIM (Chinese Association Of Integrative Medicine) in 2003 performs, and gastric cancer is divided into following six types:
(1) due to weakness of spleen and stomach: lack of appetite, abdominal distention, after food more so, or vague epigastralgia, like warm pain relieved by pressing, to feel sick nausea, vomiting food, the thin or defecation inability in large loose stool, or chronic diarrhea very then diarrhea before dawn, aqueous-grainy diarrhea, edema of lower limbs, spiritlessness and weakness, light red tongue is fat or have indentation, and tongue is white, thready and weak pulse or heavy thin;
(2) liver-stomach disharmony type: gastral cavilty rises vexed pain, and alter to two sides of body, be in a very depressed state, pain is relevant to emotion, belch, acid regurgitation, singultus, loss of appetite, light red tongue or red, white and thin fur or BOHUANG, stringy pulse;
(3) stasis blocking stomach network type: gastral cavilty twinge or as lancinated, localized pain, sore spot tenderness, can and lump matter hard, spit blood, just black, lip onyx is purple dark, darkish complexion, and purplish tongue is dark or see ecchymosis petechia, thready and hesitant pulse or puckery;
(4) gastric heat YIN-deficiency type: gastric is scorching hot, upset in the stomach, gastralgia after food, xerostomia wish drink, hunger but having no desire to eat, dysphoria with feverish sensation in the chest palms and soles, constipation with dry stool, red tongue or red deep red, few tongue or stripped fur, thready and rapid pulse;
(5) phlegm-damp stagnation type: the vexed distending pain of gastral cavity abdomen painful abdominal mass, feel sick nausea or vomiting sputum, loss of appetite or feed smooth, even anti-food accompanies volume mucus, tastelessness not for drink, dizzy heavy sensation of the body, loose stool, yellowish complexion puffiness due to deficiency, light red tongue, tongue is greasy or whiten in vain, rolling pulse or slow or carefully delay;
(6) QIXUELIANGXU type: emaciated physique, malaise, low voice timidness due to deficiency of QI, has a dizzy spell, pale complexion or sallow, and lip and nail are pale, and fidgets due to deficiency is insomnia, shortness of breath and palpitation, spontaneous sweating, edema of lower limbs, light red tongue, and Tai Bai or few tongue, deep pulse is thin and delicate.
Therapeutic Method:
Treatment group: give the embodiment of the present invention 1 capsule every day 3 times, each 4.30 days was 1 course for the treatment of, took 6 months continuously.
Matched group: according to state of an illness needs, select Combination chemotherapy, scheme used is: FOLFOX4 scheme (L-OHP85mg/m2, intravenous drip 2h, first day; CF200mg/m2, intravenous drip 2h, the 2nd, 3 days; 5-FU400mg/m2, intravenous injection, the 2nd, 3 days; 5-FU600mg/m2, continues quiet note 22h, the 2nd, 3 days), 30 days is one-period, is used in conjunction 6 cycles, Supporting Therapy of being suited the medicine to the illness after chemotherapeutic period and chemotherapy, as vein gives injection omeprazole, tropisetron injection etc.
Efficacy assessment standard: record tumor size before and after treatment, B ultrasonic, CT examination result; All patients routine examination blood, urine, stool routine, hepatic and renal function and electrocardiogram, reaction is observed in therapeutic process, efficacy evaluation is according to RECIST solid tumor the standard of curative effect evaluation: complete incidence graph (CR): all foci disappearances, occur without new focus, tumor markers is down to normally, and at least maintains 4 weeks; Partial rcsponse (PR): the most major diameter sum of tumor reduces >=and more than 30%, and at least maintain 4 weeks; Pathological changes stablizes (SD): tumor maximum diameter sum reduces and do not reach PR, or increase does not reach PD; Lesion growth (PD): maximum diameter increases >=20%, or occurs new focus; But former focus division is not very interior.Be effectively (RR) with CR+PR.
Observational technique: mid-term effects to observe the symptoms after 6 months alleviation situation, life quality in treatment, Patients after Chemotherapy detects after 3 weeks at end of chemotherapy; Late result mainly carries out the investigation of life span.
Remission status: gastric cancer often occurs fatigue and asthenia, lustreless complexion, loss of appetite, defecate uncomfortable, glutted after food, the symptoms such as nausea and vomiting, score in various degree according to these Symptoms, and calculating integral value, after treatment, symptom average product score value is improvement than more than 1/3 person that declines before treatment.
Life quality: evaluating with physical situation scoring kamofsky standard, improving 10 points more than for improving, declines 10 points below for decline, treat front and back change be less than 10 be divided into constant.
Therapeutic outcome:
Two groups of Comparison of therapeutic situations after 6 months treated by table 1:
| Group | n | CR | PR | SD | PD | RR(effective percentage) |
| Treatment group | 34 | 6 | 22 | 8 | 0 | 28（82.35%） |
| Matched group | 34 | 2 | 14 | 13 | 5 | 16（47.06%） |
Table 2 is treated two groups of remission status after 6 months and is compared:
Note: in table 2, number of cases is for alleviating number of cases/symptom number of cases.
Table 3 is treated two groups of life quality situations of change after 6 months and is compared (example (%)):
| Group | n | Rise | Stable | Decline |
| Treatment group | 34 | 15（44.12%） | 15（44.12%） | 4（11.76%） |
| Matched group | 34 | 9（26.47%） | 13（38.24%） | 12（35.29%） |
Survival rate: obtain and follow up a case by regular visits to case 58 example, from treatment to dead or lost to follow-up, wherein treatment group 30 example, matched group 28 example.
A table 4 liang group survival rate compares (example (%)):
| Group | n | > 1 year | > 3 years | > 5 years |
| Treatment group | 30 | 22（73.33%） | 19（63.33%） | 13（43.33%） |
| Matched group | 28 | 15（53.57%） | 12（42.86%） | 6（21.43%） |
Concrete case: Wang, male, 60 years old.Gastral cavilty twinge, localized pain, sore spot tenderness, can and lump matter hard, just black, lip is purple dark, darkish complexion, and purplish tongue is dark, thready and hesitant pulse.Through fibergastroscope and organize case inspection to make a definite diagnosis gastric cancer, genus mucus gastric cancer III phase is stasis blocking stomach network type gastric cancer by Syndrome Differentiation of Traditional Chinese Medicine standard diagnostics.Give Chinese medicine embodiment 1 capsule of the present invention every day 3 times, each 4, treat after 6 months, symptom is obviously alleviated, and life quality significantly improves, existence 3 years after treatment.
The above is only preferred embodiment of the present invention, and be not restriction the present invention being made to other form, any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the Equivalent embodiments of equivalent variations.But everyly do not depart from technical solution of the present invention content, any simple modification, equivalent variations and the remodeling done above embodiment according to technical spirit of the present invention, still belong to the protection domain of technical solution of the present invention.
Claims (8)
1. treat a Chinese medicine for stasis blocking stomach network type gastric cancer, it is characterized in that, the ratio of weight and number of each raw medicinal material of described Chinese medicine is as follows: Radix Sarcococcae Ruscifoliae (Herba Sarcoclccae Ruscifoliae) 15 ~ 25 parts, Folium desmoris 10 ~ 20 parts, Herba Peperomiae Dindygulensis 20 ~ 30 parts, Fomes Fomentarius 30 ~ 40 parts, Herba Scutellariae Barbatae 5 ~ 15 parts, Herba Pileae Scriptae 10 ~ 20 parts, Herba Linderniae Crustaceae 30 ~ 40 parts, Semen Impatientis 15 ~ 25 parts, Caulis Kadsurae Coccineae 20 ~ 30 parts, Radix Ixorae Chinensis 5 ~ 15 parts, Clematis aethusifolia Turcz 5 ~ 15 parts, Radix Tylophorae Yunnanensis 10 ~ 20 parts and wear 15 ~ 25 parts, stone rattan.
2. Chinese medicine as claimed in claim 1, it is characterized in that, the ratio of weight and number of each raw medicinal material of described Chinese medicine is as follows: Radix Sarcococcae Ruscifoliae (Herba Sarcoclccae Ruscifoliae) 15 ~ 20 parts, Folium desmoris 10 ~ 15 parts, Herba Peperomiae Dindygulensis 20 ~ 25 parts, Fomes Fomentarius 30 ~ 35 parts, Herba Scutellariae Barbatae 5 ~ 10 parts, Herba Pileae Scriptae 10 ~ 15 parts, Herba Linderniae Crustaceae 30 ~ 35 parts, Semen Impatientis 15 ~ 20 parts, Caulis Kadsurae Coccineae 20 ~ 25 parts, Radix Ixorae Chinensis 5 ~ 10 parts, Clematis aethusifolia Turcz 5 ~ 10 parts, Radix Tylophorae Yunnanensis 10 ~ 15 parts and wear 15 ~ 20 parts, stone rattan.
3. Chinese medicine as claimed in claim 1, it is characterized in that, the ratio of weight and number of each raw medicinal material of described Chinese medicine is as follows: Radix Sarcococcae Ruscifoliae (Herba Sarcoclccae Ruscifoliae) 16 parts, Folium desmoris 12 parts, Herba Peperomiae Dindygulensis 24 parts, Fomes Fomentarius 33 parts, Herba Scutellariae Barbatae 6 parts, Herba Pileae Scriptae 12 parts, Herba Linderniae Crustaceae 31 parts, Semen Impatientis 17 parts, Caulis Kadsurae Coccineae 23 parts, Radix Ixorae Chinensis 7 parts, Clematis aethusifolia Turcz 7 parts, Radix Tylophorae Yunnanensis 14 parts and wear 16 parts, stone rattan.
4. Chinese medicine as claimed in claim 1, it is characterized in that, the ratio of weight and number of each raw medicinal material of described Chinese medicine is as follows: Radix Sarcococcae Ruscifoliae (Herba Sarcoclccae Ruscifoliae) 18 parts, Folium desmoris 13 parts, Herba Peperomiae Dindygulensis 22 parts, Fomes Fomentarius 31 parts, Herba Scutellariae Barbatae 7 parts, Herba Pileae Scriptae 14 parts, Herba Linderniae Crustaceae 34 parts, Semen Impatientis 18 parts, Caulis Kadsurae Coccineae 21 parts, Radix Ixorae Chinensis 8 parts, Clematis aethusifolia Turcz 6 parts, Radix Tylophorae Yunnanensis 12 parts and wear 18 parts, stone rattan.
5. the Chinese medicine as described in Claims 1-4 any one, is characterized in that, the dosage form of described Chinese medicine is capsule, and its preparation method comprises the following steps:
The first step: each for described Chinese medicine raw medicinal material is mixed in proportion, adding relative to the determining alcohol of mixture quality 5 ~ 7 times is the ethanol of 85 ~ 95%, reflux 1 ~ 3 hour, extracts, and filters acquisition first extracting solution; It is the ethanol of 85 ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of medicinal residues quality 3 ~ 5 times again, reflux 1 ~ 2 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;
Second step: the dry cream that the first step obtains is placed in super micron mill and pulverizes 1 ~ 2 hour, pulverize and sieve acquisition 300 ~ 400 object micropowders;
3rd step: the micropowders obtained at second step adds relative to the microcrystalline Cellulose of its quality 0.2 ~ 0.4 times, the starch of 0.1 ~ 0.3 times, the magnesium stearate of 0.01 ~ 0.03 times, carry out mixing process, namely capsule 's content is obtained, described Capsule content is incapsulated in housing, namely obtains capsule finished product.
6. the Chinese medicine as described in Claims 1-4 any one, is characterized in that, the dosage form of described Chinese medicine is oral liquid, and its preparation method comprises the following steps:
The first step: described raw medicinal material is mixed, add relative to mixture 3 times ~ 5 times amount determining alcohol be 55% ~ 65% alcohol reflux 2 times ~ 4 times, each 2 hours ~ 3 hours, filter, filtrate merges, and reclaims ethanol, being concentrated into 70 DEG C of relative densities is the mastic of 1.30 ~ 1.32, for subsequent use;
Second step: described mastic 55 DEG C ~ 65 DEG C reduced vacuum dryings that the first step is obtained, get dry extract powder;
3rd step: is added ethanol in the described dried cream powder that second step is obtained, obtains containing alcohol mastic, and the described alcohol content containing alcohol mastic is 65% ~ 70%; Carry out chilling treatment, precipitation process, filtration treatment, recovery Ethanol Treatment by described successively containing alcohol mastic, obtain dealcoholysis mastic, wherein, the chilling treatment time is 30 ~ 40 hours;
4th step: add cane sugar powder, active carbon by described dealcoholysis mastic, carry out heat treated, filtration treatment, dilution process successively, obtain semi-finished product; The weight ratio of described dealcoholysis mastic and described cane sugar powder is 1: 0.1 ~ 0.3; The weight ratio of described dealcoholysis mastic and described active carbon is 1: 0.001 ~ 0.002; The time of described heat treated is 20 ~ 40 minutes, and temperature is 100 DEG C ~ 110 DEG C;
5th step: the more described semi-finished product that the 4th step obtains are carried out filtration treatment, embedding process, sterilization treatment successively, obtain described Chinese medicine oral liquid finished product.
7. a preparation method for Chinese medicine described in Claims 1-4 any one, is characterized in that, the dosage form of described Chinese medicine is capsule, and its preparation method comprises the following steps:
The first step: each for described Chinese medicine raw medicinal material is mixed in proportion, adding relative to the determining alcohol of mixture quality 5 ~ 7 times is the ethanol of 85 ~ 95%, reflux 1 ~ 3 hour, extracts, and filters acquisition first extracting solution; It is the ethanol of 85 ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of medicinal residues quality 3 ~ 5 times again, reflux 1 ~ 2 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;
Second step: the dry cream that the first step obtains is placed in super micron mill and pulverizes 1 ~ 2 hour, pulverize and sieve acquisition 300 ~ 400 object micropowders;
3rd step: the micropowders obtained at second step adds relative to the microcrystalline Cellulose of its quality 0.2 ~ 0.4 times, the starch of 0.1 ~ 0.3 times, the magnesium stearate of 0.01 ~ 0.03 times, carry out mixing process, namely capsule 's content is obtained, described Capsule content is incapsulated in housing, namely obtains capsule finished product.
8. a preparation method for Chinese medicine described in Claims 1-4 any one, is characterized in that, the dosage form of described Chinese medicine is oral liquid, and its preparation method comprises the following steps:
The first step: described raw medicinal material is mixed, add relative to mixture 3 times ~ 5 times amount determining alcohol be 55% ~ 65% alcohol reflux 2 times ~ 4 times, each 2 hours ~ 3 hours, filter, filtrate merges, and reclaims ethanol, being concentrated into 70 DEG C of relative densities is the mastic of 1.30 ~ 1.32, for subsequent use;
Second step: described mastic 55 DEG C ~ 65 DEG C reduced vacuum dryings that the first step is obtained, get dry extract powder;
3rd step: is added ethanol in the described dried cream powder that second step is obtained, obtains containing alcohol mastic, and the described alcohol content containing alcohol mastic is 65% ~ 70%; Carry out chilling treatment, precipitation process, filtration treatment, recovery Ethanol Treatment by described successively containing alcohol mastic, obtain dealcoholysis mastic, wherein, the chilling treatment time is 30 ~ 40 hours;
4th step: add cane sugar powder, active carbon by described dealcoholysis mastic, carry out heat treated, filtration treatment, dilution process successively, obtain semi-finished product; The weight ratio of described dealcoholysis mastic and described cane sugar powder is 1: 0.1 ~ 0.3; The weight ratio of described dealcoholysis mastic and described active carbon is 1: 0.001 ~ 0.002; The time of described heat treated is 20 ~ 40 minutes, and temperature is 100 DEG C ~ 110 DEG C;
5th step: the more described semi-finished product that the 4th step obtains are carried out filtration treatment, embedding process, sterilization treatment successively, obtain described Chinese medicine oral liquid finished product.
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