CN103599237A - Traditional Chinese medicine for treating gastric cancer of stasis in stomach collateral type and preparation method thereof - Google Patents
Traditional Chinese medicine for treating gastric cancer of stasis in stomach collateral type and preparation method thereof Download PDFInfo
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Abstract
The invention provides a traditional Chinese medicine for treating gastric cancer of stasis in stomach collateral type and a preparation method thereof. The traditional Chinese medicine comprises the following bulk drugs: sarcococca ruscifolia, desmos chinensis, peperomia dindygulensis, fomes fomentarius, scutellaria barbata, sarcandra glabra, brittle falsepimpernel herb, semen impatientis, kadsura coccinea, ixora chinensis root, clematis aethusifolia, tylophora yunnanensis rhizome and aristolochia impressinervis. The traditional Chinese medicine is capable of activating blood, resolving stasis, freeing collateral vessels, relieving pain, softening hardness, dispersing accumulation, substantially improving the symptom of blood stasis stomach collateral type gastric cancer patients, improving life quality and prolonging survival time, and is relatively small in toxic and side effects.
Description
Technical field
The present invention relates to contain the medicinal preparation that derives from plant, animal or mineral component, relate in particular to a kind of Chinese medicine for the treatment of stasis blocking stomach network type gastric cancer and preparation method thereof.
Background technology
Gastric cancer is alimentary system malignant tumour disease.Area at China's primary disease is distributed more widely, is positioned at the first place of various malignant tumor.The most patient's non-evident symptons of early gastric cancer, that a few peoples have is nauseating, vomiting or the digestive symptoms of similar Peptic Ulcers.Pain is the modal clinical symptoms of advanced gastric carcinoma with losing weight.The digestive symptoms that patient Chang You is comparatively clear and definite, as glutted after epigastric discomfort, feed, along with disease progression Upper abdominal pain increases the weight of, appetite decline, weak.
Western medical treatment mainly take operation and chemotherapy as main, but operation with chemotherapeutic efficacy all not satisfactory, and operation may to health especially weakness patient cause secondary injury.Though chemotherapy has certain curative effect, very big to human injury, there is obvious toxic-side effects.
Motherland's medical science is the definite appellation to gastric cancer not, but according to the clinical manifestation of gastric cancer, generally can belong to the categories such as " gastric abscess " in Chinese medicine, " dysphagic ", " regurgitation " " feeling of fullness ", " singultus ", " gathering ".The etiology and pathogenesis of gastric abscess is mostly relevant to diet, work and rest, the stagnation of QI, cold coagulation etc., therefore < < Plain Questions is lifted pain opinion > > and is pointed out: gastric abscess is " all because work and rest is exaggerated; intemperance of taking food; deficiency of QI in middle-JIAO; the cold-evil visitor that avails oneself of the opportunity to get in, therefore suddenly do greatly bitterly." < < Renzhai Zhi Zhi Fang, Effective Recipes from Renzhai House > > has recognized that: the cause of disease about gastric abscess mainly contains " have coldly, have heat, have dead blood, have food stagnation, have phlegm retention, have worm ".Dysphagic disease, in < <, through > >, think relevant with feelings will with body fluid, < < Taiping Royal Prescriptions > > has done definite description to its cause of disease, think " cold temperature is inappropriate, overeating, or angry QI rising in reverse order; ponder over sad; cause disorder of YIN and YANG, and chest and diaphragm painful abdominal mass plug, therefore named diaphragm gas is also." dysphagicly by regurgitation, developed, < < Longevity and Life Preservation > > says: " husband's regurgitation is dysphagic, dysphagic be regurgitation gradually.Rule for the treatment of has four, blood deficiency, and the deficiency of vital energy, has expectorant, has heat." Chinese medicine by gastric cancer typing is: (1) due to weakness of spleen and stomach; (2) liver-stomach disharmony type; (3) stasis blocking stomach network type; (4) gastric heat YIN-deficiency type; (5) the sluggish type of phlegm-damp; (6) QIXUELIANGXU type six types.
Summary of the invention
Technical problem to be solved by this invention is, a kind of Chinese medicine for the treatment of stasis blocking stomach network type gastric cancer and preparation method thereof is provided, Chinese medicine blood circulation promoting and blood stasis dispelling of the present invention, removing obstruction in the collateral to relieve pain, softening the hard mass removing food stagnancy, can significantly improve the symptom of stasis blocking stomach network type patients with gastric cancer, improves the quality of living, extend the time-to-live, and toxic and side effects is less.
In order to solve the problems of the technologies described above, the invention provides a kind of Chinese medicine for the treatment of stasis blocking stomach network type gastric cancer, its raw medicinal material comprises: Radix Sarcococcae Ruscifoliae (Herba Sarcoclccae Ruscifoliae), Folium desmoris, Herba Peperomiae Dindygulensis, Fomes Fomentarius, Herba Scutellariae Barbatae, Herba Pileae Scriptae, Herba Linderniae Crustaceae, Semen Impatientis, Caulis Kadsurae Coccineae, Radix Ixorae Chinensis, Clematis aethusifolia Turcz, Radix Tylophorae Yunnanensis and wear stone rattan.
In described Chinese medicine, the ratio of weight and number of each raw medicinal material is as follows: 15～25 parts of Radix Sarcococcae Ruscifoliae (Herba Sarcoclccae Ruscifoliae), 10～20 parts of Folium desmoris, 20～30 parts of Herba Peperomiae Dindygulensiss, 30～40 parts of Fomes Fomentarius, 5～15 parts of Herba Scutellariae Barbataes, 10～20 parts of Herba Pileae Scriptaes, 30～40 parts of Herba Linderniae Crustaceaes, 15～25 parts of Semen Impatientis, 20～30 parts of Caulis Kadsurae Coccineae, 5～15 parts of Radix Ixorae Chinensiss, 5～15 parts of Clematis aethusifolia Turczs, 10～20 parts of Radix Tylophorae Yunnanensis and wear 15～25 parts, stone rattan.
In described Chinese medicine, the ratio of weight and number of each raw medicinal material can be preferably: 15～20 parts of Radix Sarcococcae Ruscifoliae (Herba Sarcoclccae Ruscifoliae), 10～15 parts of Folium desmoris, 20～25 parts of Herba Peperomiae Dindygulensiss, 30～35 parts of Fomes Fomentarius, 5～10 parts of Herba Scutellariae Barbataes, 10～15 parts of Herba Pileae Scriptaes, 30～35 parts of Herba Linderniae Crustaceaes, 15～20 parts of Semen Impatientis, 20～25 parts of Caulis Kadsurae Coccineae, 5～10 parts of Radix Ixorae Chinensiss, 5～10 parts of Clematis aethusifolia Turczs, 10～15 parts of Radix Tylophorae Yunnanensis and wear 15～20 parts, stone rattan.
In described Chinese medicine, the ratio of weight and number of each raw medicinal material also can be preferably: 16 parts of Radix Sarcococcae Ruscifoliae (Herba Sarcoclccae Ruscifoliae), 12 parts of Folium desmoris, 24 parts of Herba Peperomiae Dindygulensiss, 33 parts of Fomes Fomentarius, 6 parts of Herba Scutellariae Barbataes, 12 parts of Herba Pileae Scriptaes, 31 parts of Herba Linderniae Crustaceaes, 17 parts of Semen Impatientis, 23 parts of Caulis Kadsurae Coccineae, 7 parts of Radix Ixorae Chinensiss, 7 parts of Clematis aethusifolia Turczs, 14 parts of Radix Tylophorae Yunnanensis and wear 16 parts, stone rattan.
In described Chinese medicine, the ratio of weight and number of each raw medicinal material also can be preferably: 18 parts of Radix Sarcococcae Ruscifoliae (Herba Sarcoclccae Ruscifoliae), 13 parts of Folium desmoris, 22 parts of Herba Peperomiae Dindygulensiss, 31 parts of Fomes Fomentarius, 7 parts of Herba Scutellariae Barbataes, 14 parts of Herba Pileae Scriptaes, 34 parts of Herba Linderniae Crustaceaes, 18 parts of Semen Impatientis, 21 parts of Caulis Kadsurae Coccineae, 8 parts of Radix Ixorae Chinensiss, 6 parts of Clematis aethusifolia Turczs, 12 parts of Radix Tylophorae Yunnanensis and wear 18 parts, stone rattan.
The present invention also provides the preparation method of above-mentioned Chinese medicine, and the dosage form of described Chinese medicine is capsule, and its preparation method comprises the following steps:
The first step: each raw medicinal material of described Chinese medicine is mixed in proportion, adds the ethanol that the determining alcohol with respect to 2～3 times of mixture qualities is 80～90%, reflux 2～3 hours, extracts, and filters and obtains the first extracting solution; The medicinal residues that filter to obtain add the ethanol that the determining alcohol with respect to 1～2 times of medicinal residues quality is 80～90% again, and reflux 1～2 hour, extracts, and filters and obtains the second extracting solution; The first extracting solution and the second extracting solution are merged, and concentrating under reduced pressure is removed alcohol solvent, dry, obtains and gets dry extract;
Second step: the dry cream that the first step is obtained is placed in super micron mill to be pulverized 1～3 hour, pulverizes and sieves and obtains 100～300 object micropowders;
The 3rd step: the micropowders obtaining at second step adds the microcrystalline Cellulose with respect to 0.2～0.3 times of its quality, the starch of 0.1～0.2 times, the magnesium stearate of 0.01～0.02 times, mix processing, obtain capsule 's content, described Capsule content is incapsulated in housing, obtain capsule finished product.
The present invention also provides the preparation method of above-mentioned Chinese medicine, and the dosage form of described Chinese medicine is oral liquid, and its preparation method comprises the following steps:
The first step: described raw medicinal material is mixed to the alcohol reflux that to add with respect to 3 times～5 times amount determining alcohols of mixture be 55%～65% 2 times～4 times, each 2 hours～3 hours, filter, filtrate merges, and reclaims ethanol, be concentrated into the mastic that 70 ℃ of relative densities are 1.30～1.32, standby;
Second step: 55 ℃～65 ℃ reduced vacuum of described mastic that the first step is obtained are dry, and powder gets dry extract;
The 3rd step: add ethanol in the described dried cream powder will second step obtaining, and obtain containing alcohol mastic, described is 65%～70% containing alcohol mastic containing alcohol amount; By described, containing alcohol mastic, carry out successively cold preservation processing, precipitation process, filtration treatment, recovery Ethanol Treatment, obtain dealcoholysis mastic, wherein, the cold preservation processing time is 30～40 hours;
The 4th step: will add cane sugar powder, active carbon in described dealcoholysis mastic, carry out successively heat treated, filtration treatment, dilution process, obtain semi-finished product; The weight ratio of described dealcoholysis mastic and described cane sugar powder is 1: 0.1～0.3; The weight ratio of described dealcoholysis mastic and described active carbon is 1: 0.001～0.002; The time of described heat treated is 20～40 minutes, and temperature is 100 ℃～110 ℃;
The 5th step: the described semi-finished product that again the 4th step obtained carry out filtration treatment, embedding processing, sterilization treatment successively, obtain described Chinese medicine oral liquid finished product.
Beneficial effect of the present invention: Chinese medicine blood circulation promoting and blood stasis dispelling of the present invention, removing obstruction in the collateral to relieve pain, softening the hard mass removing food stagnancy, can significantly improve the symptom of stasis blocking stomach network type patients with gastric cancer, improves the quality of living, and extend the time-to-live, and toxic and side effects is less.
The specific embodiment
The invention provides a kind of Chinese medicine for the treatment of stasis blocking stomach network type gastric cancer and preparation method thereof, its raw medicinal material comprises: Radix Sarcococcae Ruscifoliae (Herba Sarcoclccae Ruscifoliae), Folium desmoris, Herba Peperomiae Dindygulensis, Fomes Fomentarius, Herba Scutellariae Barbatae, Herba Pileae Scriptae, Herba Linderniae Crustaceae, Semen Impatientis, Caulis Kadsurae Coccineae, Radix Ixorae Chinensis, Clematis aethusifolia Turcz, Radix Tylophorae Yunnanensis and wear stone rattan.
In above-mentioned Chinese medicine, the pharmacology of each raw medicinal material is as follows:
Radix Sarcococcae Ruscifoliae (Herba Sarcoclccae Ruscifoliae): pungent, hardship, flat.Return liver, stomach warp.Promoting flow of QI and blood; Wind-expelling pain-stopping.Main gastralgia, anemofrigid-damp arthralgia, traumatic injury.< < Yunnan Chinese herbal medicine > >: active, pain relieving.Treat for stomachache, traumatic injury.
Folium desmoris: hardship, pungent, temperature.Return spleen, Liver Channel.Expelling wind and removing dampness, blood-activating analgetic, invigorating the spleen and regulating the stomach, preventing the attack (or recurrence) of malaria parasite killing.Main rheumatic ostalgia, malaria, edema, traumatic injury, rubella, scabies, rotten foot.
Herba Peperomiae Dindygulensis: pungent, cool.Return spleen, stomach, liver, kidney channel.Heat-clearing and toxic substances removing, blood stasis-eliminating and stagnation-dissipating, inducing diuresis to remove edema.Main lung-heat cough with asthma, measles, sore, cancerous protuberance, burn and scald, traumatic injury, oedema due to nephritis.< < Yunnan Chinese herbal medicine selects > >: eliminating stasis and resolving masses, and anticancer.Control gastric cancer, esophageal carcinoma, hepatocarcinoma, breast carcinoma, pulmonary carcinoma.
Fomes Fomentarius: micro-hardship, property is flat.Removing food stagnancy, blood stasis dispelling, anticancer.Staple food is long-pending, the esophageal carcinoma, gastric cancer, uterus carcinoma.
Herba Scutellariae Barbatae: acrid in the mouth, hardship, cold in nature.Return lung, liver, kidney channel.Heat-clearing and toxic substances removing, dissipating blood stasis hemostasis, inducing diuresis to remove edema, analgesic therapy.Control haematemesis, epistaxis, stranguria with blood, bloody dysentery, jaundice, has sore throat, lung abscess, furuncle, scrofula, sore, cancerous protuberance, traumatic injury knife injury, venom.< < Quanzhou book on Chinese herbal medicine > >: heat clearing away, removing toxic substances, dispels the wind, loose blood, circulation of qi promoting, diuretic, dredging collateral, removing blood stasis with potent drugs, pain relieving.Main stranguria with blood for oral administration, spits blood, epistaxis; Venom is controlled in external, carbuncle, furuncle, innominate toxic swelling.
Herba Pileae Scriptae: pungent, flat.Anti-inflammation, expelling wind and removing dampness, promoting blood circulation and stopping pain.Control pneumonia, acute appendicitis, acute gastroenteritis, bacillary dysentery, rheumatalgia, traumatic injury, fracture.The herbal > > in east, < < Fujian: spleen invigorating, invigorate blood circulation, quench the thirst, subside a swelling swollen.Diseases caused by exogenous pathogenic factor after managing property. alternate attack of chill and fever, head-body-pain, thirsty, swelling.
Herba Linderniae Crustaceae: micro-hardship, light, cool.Clearing away heat-damp and promoting diuresis, promoting blood circulation and stopping pain.Main anemopyretic cold, damp-heat dysentery, oedema due to nephritis, leucorrhea, menoxenia, carbuncle furuncle and phyma poison, venom, traumatic injury.< < Guangxi medicine is planted register > >: control traumatic injury, acute mastitis, gastric cancer.
Semen Impatientis: micro-hardship, pungent, temperature.Return spleen, Liver Channel.Anticancer, scattered silt detumescence relieves internal heat.Removing blood stasis softening the hard mass, removing food stagnancy.For mass in the abdomen, amenorrhea, dysphagic.
Caulis Kadsurae Coccineae: pungent, micro-hardship, warm in nature.Promoting the circulation of QI to relieve pain, dissipating blood stasis dredging collateral.For gastric and duodenal ulcers, chronic gastritis, acute gastroenteritis, rheumatic arthralgia, traumatic injury, fracture, dysmenorrhea, postnatal blood stasis stomachache, colicky.< < Chinese Plants will > >: root is medicinal, energy promoting flow of QI and blood, reducing swelling and alleviating pain, controls gastropathy, rheumatic ostalgia, traumatic injury stasis of blood Tong，Bing Wei gynecological common medicine.
Radix Ixorae Chinensis: hardship, micro-puckery, cool.Return lung, stomach warp.Clearing away heat and cooling blood, promoting blood circulation and stopping pain.Main cough, hemoptysis, rheumatic arthritis, stomachache, women's amenorrhea, skin infection swells and ache, traumatic injury.
Clematis aethusifolia Turcz: pungent, temperature.Return liver, stomach warp.Dispelling wind and removing obstruction in the collateral, pain relieving, invigorating the stomach and promoting digestion, parasite killing.Main air pain of dampness syndrome, dyspepsia, vomiting, cysticercosis, eczema scrotum, sore and toxic.
Radix Tylophorae Yunnanensis: micro-hardship, pungent, warm in nature.Return liver, spleen channel.Channels sootheing and network vessel quickening, promoting blood circulation and stopping pain.Dispelling the wind and dampness pathogens osteodynia, hepatitis, gastric ulcer, poliomyelitis sequela, traumatic injury.< < Yunnan Chinese herbal medicine > >: relaxing muscles and tendons to promote blood circulation, menstruction regulating and pain relieving.Control traumatic injury, rheumatic ostalgia, hepatitis, gastric ulcer, chronic consumptive disease, pernicious malaria.
Wear stone rattan: hardship, pungent, temperature.Return liver, stomach, large intestine channel.Dispelling wind and removing obstruction in the collateral, promoting blood circulation and stopping pain.Dispelling the wind and dampness pathogens arthralgia pain, stomachache, traumatic injury pain caused by ecchymoma, enteritis, poliomyelitis sequela.
In described Chinese medicine, the ratio of weight and number of each raw medicinal material is as follows: 15～25 parts of Radix Sarcococcae Ruscifoliae (Herba Sarcoclccae Ruscifoliae), 10～20 parts of Folium desmoris, 20～30 parts of Herba Peperomiae Dindygulensiss, 30～40 parts of Fomes Fomentarius, 5～15 parts of Herba Scutellariae Barbataes, 10～20 parts of Herba Pileae Scriptaes, 30～40 parts of Herba Linderniae Crustaceaes, 15～25 parts of Semen Impatientis, 20～30 parts of Caulis Kadsurae Coccineae, 5～15 parts of Radix Ixorae Chinensiss, 5～15 parts of Clematis aethusifolia Turczs, 10～20 parts of Radix Tylophorae Yunnanensis and wear 15～25 parts, stone rattan.
In described Chinese medicine, the ratio of weight and number of each raw medicinal material can be preferably: 15～20 parts of Radix Sarcococcae Ruscifoliae (Herba Sarcoclccae Ruscifoliae), 10～15 parts of Folium desmoris, 20～25 parts of Herba Peperomiae Dindygulensiss, 30～35 parts of Fomes Fomentarius, 5～10 parts of Herba Scutellariae Barbataes, 10～15 parts of Herba Pileae Scriptaes, 30～35 parts of Herba Linderniae Crustaceaes, 15～20 parts of Semen Impatientis, 20～25 parts of Caulis Kadsurae Coccineae, 5～10 parts of Radix Ixorae Chinensiss, 5～10 parts of Clematis aethusifolia Turczs, 10～15 parts of Radix Tylophorae Yunnanensis and wear 15～20 parts, stone rattan.
In described Chinese medicine, the ratio of weight and number of each raw medicinal material also can be preferably: 16 parts of Radix Sarcococcae Ruscifoliae (Herba Sarcoclccae Ruscifoliae), 12 parts of Folium desmoris, 24 parts of Herba Peperomiae Dindygulensiss, 33 parts of Fomes Fomentarius, 6 parts of Herba Scutellariae Barbataes, 12 parts of Herba Pileae Scriptaes, 31 parts of Herba Linderniae Crustaceaes, 17 parts of Semen Impatientis, 23 parts of Caulis Kadsurae Coccineae, 7 parts of Radix Ixorae Chinensiss, 7 parts of Clematis aethusifolia Turczs, 14 parts of Radix Tylophorae Yunnanensis and wear 16 parts, stone rattan.
In described Chinese medicine, the ratio of weight and number of each raw medicinal material also can be preferably: 18 parts of Radix Sarcococcae Ruscifoliae (Herba Sarcoclccae Ruscifoliae), 13 parts of Folium desmoris, 22 parts of Herba Peperomiae Dindygulensiss, 31 parts of Fomes Fomentarius, 7 parts of Herba Scutellariae Barbataes, 14 parts of Herba Pileae Scriptaes, 34 parts of Herba Linderniae Crustaceaes, 18 parts of Semen Impatientis, 21 parts of Caulis Kadsurae Coccineae, 8 parts of Radix Ixorae Chinensiss, 6 parts of Clematis aethusifolia Turczs, 12 parts of Radix Tylophorae Yunnanensis and wear 18 parts, stone rattan.
The present invention also provides the preparation method of above-mentioned Chinese medicine, and the dosage form of described Chinese medicine is capsule, and its preparation method comprises the following steps:
The first step: each raw medicinal material of described Chinese medicine is mixed in proportion, adds the ethanol that the determining alcohol with respect to 2～3 times of mixture qualities is 80～90%, reflux 2～3 hours, extracts, and filters and obtains the first extracting solution; The medicinal residues that filter to obtain add the ethanol that the determining alcohol with respect to 1～2 times of medicinal residues quality is 80～90% again, and reflux 1～2 hour, extracts, and filters and obtains the second extracting solution; The first extracting solution and the second extracting solution are merged, and concentrating under reduced pressure is removed alcohol solvent, dry, obtains and gets dry extract;
Second step: the dry cream that the first step is obtained is placed in super micron mill to be pulverized 1～3 hour, pulverizes and sieves and obtains 100～300 object micropowders;
The 3rd step: the micropowders obtaining at second step adds the microcrystalline Cellulose with respect to 0.2～0.3 times of its quality, the starch of 0.1～0.2 times, the magnesium stearate of 0.01～0.02 times, mix processing, obtain capsule 's content, described Capsule content is incapsulated in housing, obtain capsule finished product.
The present invention also provides the preparation method of above-mentioned Chinese medicine, and the dosage form of described Chinese medicine is oral liquid, and its preparation method comprises the following steps:
The first step: described raw medicinal material is mixed to the alcohol reflux that to add with respect to 3 times～5 times amount determining alcohols of mixture be 55%～65% 2 times～4 times, each 2 hours～3 hours, filter, filtrate merges, and reclaims ethanol, be concentrated into the mastic that 70 ℃ of relative densities are 1.30～1.32, standby;
Second step: the described mastic that the first step is obtained mixes, 55 ℃～65 ℃ reduced vacuum are dry, and powder gets dry extract;
The 3rd step: add ethanol in the described dried cream powder will second step obtaining, and obtain containing alcohol mastic, described is 65%～70% containing alcohol mastic containing alcohol amount; By described, containing alcohol mastic, carry out successively cold preservation processing, precipitation process, filtration treatment, recovery Ethanol Treatment, obtain dealcoholysis mastic, wherein, the cold preservation processing time is 30～40 hours;
The 4th step: will add cane sugar powder, active carbon in described dealcoholysis mastic, carry out successively heat treated, filtration treatment, dilution process, obtain semi-finished product; The weight ratio of described dealcoholysis mastic and described cane sugar powder is 1: 0.1～0.3; The weight ratio of described dealcoholysis mastic and described active carbon is 1: 0.001～0.002; The time of described heat treated is 20～40 minutes, and temperature is 100 ℃～110 ℃;
The 5th step: the described semi-finished product that again the 4th step obtained carry out filtration treatment, embedding processing, sterilization treatment successively, obtain described Chinese medicine oral liquid finished product.
Below adopt embodiment to describe embodiments of the present invention in detail, fully understand whereby how application technology means solve technical problem in the present invention, reach technique effect and implement according to this.
Embodiment 1: capsule
Get Radix Sarcococcae Ruscifoliae (Herba Sarcoclccae Ruscifoliae) 160g, Folium desmoris 120g, Herba Peperomiae Dindygulensis 240g, Fomes Fomentarius 330g, Herba Scutellariae Barbatae 60g, Herba Pileae Scriptae 120g, Herba Linderniae Crustaceae 310g, Semen Impatientis 170g, Caulis Kadsurae Coccineae 230g, Radix Ixorae Chinensis 70g, Clematis aethusifolia Turcz 70g, Radix Tylophorae Yunnanensis 140g and wear stone rattan 160g;
Preparation according to the following steps:
The first step: each raw medicinal material of described Chinese medicine is mixed in proportion, adds the ethanol that the determining alcohol with respect to 3 times of mixture qualities is 80%, reflux 2 hours, extracts, and filters and obtains the first extracting solution; The medicinal residues that filter to obtain add the ethanol that the determining alcohol with respect to 2 times of medicinal residues quality is 80% again, and reflux 1 hour, extracts, and filters and obtains the second extracting solution; The first extracting solution and the second extracting solution are merged, and concentrating under reduced pressure is removed alcohol solvent, dry, obtains and gets dry extract;
Second step: the dry cream that the first step is obtained is placed in super micron mill to be pulverized 2 hours, pulverizes and sieves and obtains 200 object micropowders;
The 3rd step: the micropowders obtaining at second step adds the microcrystalline Cellulose with respect to 0.3 times of its quality, the starch of 0.2 times, the magnesium stearate of 0.01 times, mix processing, obtain capsule 's content, described Capsule content is incapsulated in housing, obtain capsule finished product.
Embodiment 2: oral liquid
Get Radix Sarcococcae Ruscifoliae (Herba Sarcoclccae Ruscifoliae) 180g, Folium desmoris 130g, Herba Peperomiae Dindygulensis 220g, Fomes Fomentarius 310g, Herba Scutellariae Barbatae 70g, Herba Pileae Scriptae 140g, Herba Linderniae Crustaceae 340g, Semen Impatientis 180g, Caulis Kadsurae Coccineae 210g, Radix Ixorae Chinensis 80g, Clematis aethusifolia Turcz 60g, Radix Tylophorae Yunnanensis 120g and wear stone rattan 180g;
Preparation according to the following steps:
The first step: described raw medicinal material is mixed, the alcohol reflux that to add with respect to 5 times of amount determining alcohols of mixture be 65% 3 times, each 2 hours, to filter, filtrate merges, and reclaims ethanol, is concentrated into the mastic that 70 ℃ of relative densities are 1.30, standby;
Second step: the described mastic that the first step is obtained, 65 ℃ of reduced vacuum are dry, and powder gets dry extract;
The 3rd step: add ethanol in the described dried cream powder will second step obtaining, and obtain containing alcohol mastic, described is 70% containing alcohol mastic containing alcohol amount; By described, containing alcohol mastic, carry out successively cold preservation processing, precipitation process, filtration treatment, recovery Ethanol Treatment, obtain dealcoholysis mastic, wherein, the cold preservation processing time is 30 hours;
The 4th step: will add cane sugar powder, active carbon in described dealcoholysis mastic, carry out successively heat treated, filtration treatment, dilution process, obtain semi-finished product; The weight ratio of described dealcoholysis mastic and described cane sugar powder is 1: 0.2; The weight ratio of described dealcoholysis mastic and described active carbon is 1: 0.001; The time of described heat treated is 30 minutes, and temperature is 100 ℃;
The 5th step: the described semi-finished product that again the 4th step obtained carry out filtration treatment, embedding processing, sterilization treatment successively, obtain described Chinese medicine oral liquid finished product.
Toxicity test:
Acute toxicity testing: 60 of application mices, male and female half and half, body weight 28～38g, carries out acute toxicity test.Mice is divided into two groups at random, be matched group and administration group, before experiment, fasting is 12 hours, and the Chinese medicine capsules of embodiments of the invention 1 preparation is dissolved in water, (concentration is 7.46g crude drug/ml, maximum concentration) gavage, gavage volume is that 5ml/kg(is that single-dose dosage is 37.3 crude drugs/kg), matched group gives equivalent normal saline, administration in one day 2 times, delivery time 6 hours, after administration, Continuous Observation is 14 days, and record mice toxic reaction and death toll.Experimental result shows: with matched group comparison, after administration, mice has no notable difference, experiment Continuous Observation 14 days, and mice overall health of patients, diet, drinking-water, body weight gain are all normal.Mice oral administration gavage tablet of the present invention is LD50>37.3 crude drug/kg, and every day, maximum dosage-feeding was 74.6 crude drugs/kg/ day.Chinese medicine clinical application amount of the present invention is 7.8g crude drug/day/people, becomes body weight for humans in 60KG, and average dosage is 0.13g crude drug/kg/ day.By weighing machine: the dosis tolerata of mice (average weight take 33g) oral administration gavage Chinese medicine of the present invention is quantity 574 times.Therefore Chinese medicine acute toxicity of the present invention is extremely low, clinical drug safety.
Long term toxicity test: Chinese medicine embodiment 1 capsule of the present invention to mice by 13.43,19.25 and 15 weeks (1.0ml/100g body weight of 38.32g crude drug/kg continuous use, every day 2 times) and drug withdrawal after 3 weeks, result shows: Chinese medicine of the present invention all has no significant effect indexs such as the hair of mice, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat, internal organs naked eyes do not find that difference changes and histological examination result shows, medication 15 weeks and drug withdrawal are after 3 weeks, and Organs of Mice is all without obviously changing.Illustrate that toxicity is little after Chinese medicine of the present invention is to mice long-term prescription, after drug withdrawal, also there is no difference reaction, application safety.
Clinical data:
Then case selection: whole 68 routine cases are all diagnosed as gastric cancer through fibergastroscope and histopathological examination is stasis blocking stomach network type gastric cancer through Syndrome Types of TCM.Male 46 people wherein, women 22 people, 37～79 years old age.Press TNM method, II phases 10 example wherein, III phases 34 example, IV phases 24 example by stages.Adenocarcinoma ulcerative 16 examples wherein, adenocarcinoma infiltrating 19 examples, papillary adenocarcinoma 3 examples, poorly differentiated adenocarcinoma 15 examples, print army cell carcinoma 2 examples, adenocarcinoma,mucoid 13 examples.
Be divided at random treatment group and matched group, treatment group 34 people wherein, male 23 people, women 11 people, 38～79 years old age.II phases 5 example, III phases 18 example, IV phases 11 example.Adenocarcinoma ulcerative 8 examples wherein, adenocarcinoma infiltrating 10 examples, papillary adenocarcinoma 2 examples, poorly differentiated adenocarcinoma 7 examples, print army cell carcinoma 1 example, adenocarcinoma,mucoid 6 examples; Matched group 34 people, male 23 people, women 11 people, 37～79 years old age.II phases 5 example, III phases 16 example, IV phases 13 example.Adenocarcinoma ulcerative 8 examples wherein, adenocarcinoma infiltrating 9 examples, papillary adenocarcinoma 1 example, poorly differentiated adenocarcinoma 8 examples, print army cell carcinoma 1 example, adenocarcinoma,mucoid 7 examples.Two groups at equal not statistically significants of comparing difference (p>0.05) such as age, sex, clinical stages, symptom and pathologicals.
Diagnostic criteria: being gastric cancer by following Western medicine diagnose standard diagnostics, is then stasis blocking stomach network type gastric cancer by the further typing of following tcm diagnosis standard.
Western medicine diagnose standard: with reference to People's Republic of China's health industry standard (ws316-2010) diagnosing gastric cancer standard: (1) symptom: gastric cancer lacks specificity clinical symptoms; Early gastric cancer is often asymptomatic, epigastric discomfort or pain, loss of appetite, become thin, weak, nauseating, vomiting, hematemesis or melena, diarrhoea, constipation, heating, abdominal part occur that the symptoms such as lump likely appear at the different phase in gastric cancer generation evolution, but all without specificity.(2) sign: gastric cancer lacks specificity sign; Early gastric cancer is normal without obvious sign, late gastric cancer or likely occur that epigastrium lump, rectum the place ahead touch the signs such as swollen thing, supraclavicular lymph nodes enlargement while there is metastasis focus.(3) fibergastroscopy: the sensitivity of fibergastroscopy diagnosis of gastric cancer is high by the accurate position of positioning tumor of fibergastroscopy, can obtain tissue specimen to complete pathological biopsy simultaneously.Nearly all patient who is diagnosed as gastric cancer through upper digestive tract contrast examination needs to accept fibergastroscopy and pathological biopsy to make a definite diagnosis again.Therefore, should directly select gastroscope to replace upper digestive tract radiography as the first-selected inspection method of diagnosis of gastric cancer.(4) upper digestive tract radiography: upper digestive tract contrast examination safety, noinvasive, without calm and be widely used.But for gastric cancer (particularly early gastric cancer) diagnostic sensitivity lower than fibergastroscopy.Should can not carry out the medical institutions of fibergastroscopy or select the inspection method as diagnosing gastric cancer to tolerating gastroscopic patient.(5) histodiagnosis: histopathologic diagnosis is definite diagnosis basis of gastric cancer, before implementing various oncotherapy means, should obtain pathological diagnosis foundation as far as possible.(6) computer body-layer scanning (CT): computer body-layer scanning has value at the aspects such as extent of disease, metastases in local lymph node situation and metastasis situation evaluating gastric cancer, should be as the first-selected inspection method of preoperative staging of gastric carcinoma.(7) diagnosis: the diagnosis of gastric cancer cannot rely on merely the clinical datas such as medical history, sings and symptoms to be established.Conventional clinical diagnosis of applying the method establishment gastric cancer such as upper digestive tract radiography and fibergastroscopy clinically, should using the latter as the prefered method of diagnosing.Making a definite diagnosis according to being histopathological examination result of gastric cancer.
Syndrome Differentiation of Traditional Chinese Medicine standard: the Standards of Chinese Medical Syndrome Differentiation in the combination of Chinese and Western medicine diagnosis and treatment project of the gastric cancer of formulating with reference to digestive system disease Professional Committee of CAIM (Chinese Association Of Integrative Medicine) in 2003 is carried out, and gastric cancer is divided into following six types:
(1) due to weakness of spleen and stomach: lack of appetite, abdominal distention, after food, more so, or vague epigastralgia, likes warm pain relieved by pressing, the nausea of feeling sick, vomiting food, the thin or defecation inability in large loose stool, or chronic diarrhea diarrhea before dawn very, aqueous-grainy diarrhea, edema of lower limbs, spiritlessness and weakness, light red tongue is fat or have indentation, and tongue is white, thready and weak pulse or heavy thin;
(2) liver-stomach disharmony type: the gastral cavilty vexed pain that rises, alter to two sides of body, be in a very depressed state, pain is relevant to emotion, belch, acid regurgitation, singultus, loss of appetite, light red tongue or red, white and thin fur or BOHUANG, stringy pulse;
(3) stasis blocking stomach network type: gastral cavilty twinge or as lancinate, localized pain, sore spot tenderness, can and lump matter hard, spit blood, just black, lip onyx is purple dark, darkish complexion, purplish tongue is dark or see ecchymosis petechia, thready and hesitant pulse or puckery;
(4) gastric heat YIN-deficiency type: gastric is scorching hot, upset in the stomach, gastralgia after food, xerostomia wish drink, hunger but having no desire to eat, dysphoria with feverish sensation in the chest palms and soles, constipation with dry stool, red tongue or red deep red, few tongue or stripped fur, thready and rapid pulse;
(5) the sluggish type of phlegm-damp: the vexed distending pain of gastral cavity abdomen painful abdominal mass, feel sick nausea or vomiting sputum, loss of appetite or feed are not smooth, and even anti-food accompanies volume mucus, and tastelessness is wish drink not, dizzy heavy sensation of the body, loose stool, yellowish complexion puffiness due to deficiency, light red tongue, the white greasy or whiten of tongue, rolling pulse or slow or carefully slow;
(6) QIXUELIANGXU type: emaciated physique, malaise, low voice timidness due to deficiency of QI, has a dizzy spell, pale complexion or sallow, lip and nail are pale, and fidgets due to deficiency is insomnia, shortness of breath and palpitation, spontaneous sweating, edema of lower limbs, light red tongue, Tai Bai or few tongue, a little less than deep-thready pulse.
Therapeutic Method:
Treatment group: give 1 capsule every day of the embodiment of the present invention 3 times, each 4.Within 30 days, be 1 course for the treatment of, take continuously 6 months.
Matched group: according to state of an illness needs, select Combination chemotherapy, scheme used is: FOLFOX4 scheme (L-OHP85mg/m2, intravenous drip 2h, first day; CF200mg/m2, intravenous drip 2h, the 2nd, 3 days; 5-FU400mg/m2, intravenous injection, the 2nd, 3 days; 5-FU600mg/m2, continuous intravenous is noted 22h, the 2nd, 3 days), 30 days is one-period, is used in conjunction 6 cycles, the Supporting Therapy of being suited the medicine to the illness after chemotherapeutic period and chemotherapy, and as vein gives injection omeprazole, tropisetron injection etc.
Efficacy assessment standard: record tumor size, B ultrasonic, CT examination result before and after treatment; All patients routine examination blood, urine, stool routine, hepatic and renal function and electrocardiogram, in therapeutic process, observe reaction, efficacy evaluation is according to RECIST solid tumor the standard of curative effect evaluation: alleviate completely (CR): whole foci disappearances, without new focus, occur, tumor markers is down to normally, and at least maintains 4 weeks; Partial rcsponse (PR): the major diameter sum of tumor dwindles >=and more than 30%, and at least maintain 4 weeks; Pathological changes is stablized (SD): tumor maximum diameter sum is dwindled and do not reached PR, or increase does not reach PD; Lesion growth (PD): maximum diameter increases >=20%, or occurs new focus; But former focus division is not very interior.Take CR+PR as effective (RR).
Observational technique: mid-term effects is at treatment observe the symptoms after 6 months alleviation situation, life quality, and Patients after Chemotherapy is in end of chemotherapy detection after 3 weeks; Late result is mainly carried out the investigation of life span.
Remission situation: fatigue and asthenia, lustreless complexion, loss of appetite often appear in gastric cancer, defecate uncomfortable, glutted after food, the symptoms such as nausea and vomiting, according to these Symptoms, score in various degree, and calculating integral value, after treatment, symptom average product score value is improvement than the front 1/3 above person that declines for the treatment of.
Life quality: with physical situation scoring kamofsky standard, evaluate, improve 10 minutes above for improving, decline 10 minutes following for declining, before and after treatment, change be less than 10 be divided into constant.
Therapeutic outcome:
Table 1 treatment two groups of Comparison of therapeutic situations after 6 months:
| Group | n | CR | PR | SD | PD | RR(effective percentage) |
| Treatment group | 34 | 6 | 22 | 8 | 0 | 28（82.35%） |
| Matched group | 34 | 2 | 14 | 13 | 5 | 16（47.06%） |
Table 2 treatment two groups of remission situations comparison after 6 months:
Note: in table 2, number of cases is for alleviating number of cases/symptom number of cases.
Table 3 treatment two groups of life quality situations of change comparison after 6 months (example (%)):
| Group | n | Rise | Stable | Decline |
| Treatment group | 34 | 15（44.12%） | 15（44.12%） | 4（11.76%） |
| Matched group | 34 | 9（26.47%） | 13（38.24%） | 12（35.29%） |
Survival rate: obtain and to follow up a case by regular visits to case 58 examples, from treatment till dead or lost to follow-up, treatment group 30 examples wherein, matched group 28 examples.
Table 4 liang group survival rate comparison (example (%)):
| Group | n | > 1 year | > 3 years | > 5 years |
| Treatment group | 30 | 22（73.33%） | 19（63.33%） | 13（43.33%） |
| Matched group | 28 | 15（53.57%） | 12（42.86%） | 6（21.43%） |
Concrete case: Wang, male, 60 years old.Gastral cavilty twinge, localized pain, sore spot tenderness, can and lump matter hard, just black, lip is purple dark, darkish complexion, purplish tongue is dark, thready and hesitant pulse.Through fibergastroscope with organize case to check and make a definite diagnosis gastric cancer, the genus mucus gastric cancer III phase is stasis blocking stomach network type gastric cancer by Syndrome Differentiation of Traditional Chinese Medicine standard diagnostics.Give 1 capsule every day of Chinese medicine embodiment of the present invention 3 times, each 4, to treat after 6 months, symptom is obviously alleviated, and life quality obviously improves, and after treatment, existence is 3 years.
The above, be only preferred embodiment of the present invention, is not the present invention to be done to the restriction of other form, and any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the equivalent embodiment of equivalent variations.But every technical solution of the present invention content that do not depart from, any simple modification, equivalent variations and the remodeling above embodiment done according to technical spirit of the present invention, still belong to the protection domain of technical solution of the present invention.
Claims (9)
1. a Chinese medicine for the treatment of stasis blocking stomach network type gastric cancer, is characterized in that, each raw medicinal material of described Chinese medicine comprises: Radix Sarcococcae Ruscifoliae (Herba Sarcoclccae Ruscifoliae), Folium desmoris, Herba Peperomiae Dindygulensis, Fomes Fomentarius, Herba Scutellariae Barbatae, Herba Pileae Scriptae, Herba Linderniae Crustaceae, Semen Impatientis, Caulis Kadsurae Coccineae, Radix Ixorae Chinensis, Clematis aethusifolia Turcz, Radix Tylophorae Yunnanensis and wear stone rattan.
2. Chinese medicine as claimed in claim 1, is characterized in that, the ratio of weight and number of described each raw medicinal material of Chinese medicine is as follows: 15～25 parts of Radix Sarcococcae Ruscifoliae (Herba Sarcoclccae Ruscifoliae), 10～20 parts of Folium desmoris, 20～30 parts of Herba Peperomiae Dindygulensiss, 30～40 parts of Fomes Fomentarius, 5～15 parts of Herba Scutellariae Barbataes, 10～20 parts of Herba Pileae Scriptaes, 30～40 parts of Herba Linderniae Crustaceaes, 15～25 parts of Semen Impatientis, 20～30 parts of Caulis Kadsurae Coccineae, 5～15 parts of Radix Ixorae Chinensiss, 5～15 parts of Clematis aethusifolia Turczs, 10～20 parts of Radix Tylophorae Yunnanensis and wear 15～25 parts, stone rattan.
3. Chinese medicine as claimed in claim 1 or 2, is characterized in that, the ratio of weight and number of described each raw medicinal material of Chinese medicine is as follows: 15～20 parts of Radix Sarcococcae Ruscifoliae (Herba Sarcoclccae Ruscifoliae), 10～15 parts of Folium desmoris, 20～25 parts of Herba Peperomiae Dindygulensiss, 30～35 parts of Fomes Fomentarius, 5～10 parts of Herba Scutellariae Barbataes, 10～15 parts of Herba Pileae Scriptaes, 30～35 parts of Herba Linderniae Crustaceaes, 15～20 parts of Semen Impatientis, 20～25 parts of Caulis Kadsurae Coccineae, 5～10 parts of Radix Ixorae Chinensiss, 5～10 parts of Clematis aethusifolia Turczs, 10～15 parts of Radix Tylophorae Yunnanensis and wear 15～20 parts, stone rattan.
4. the Chinese medicine as described in claims 1 to 3, is characterized in that, the ratio of weight and number of described each raw medicinal material of Chinese medicine is as follows: 16 parts of Radix Sarcococcae Ruscifoliae (Herba Sarcoclccae Ruscifoliae), 12 parts of Folium desmoris, 24 parts of Herba Peperomiae Dindygulensiss, 33 parts of Fomes Fomentarius, 6 parts of Herba Scutellariae Barbataes, 12 parts of Herba Pileae Scriptaes, 31 parts of Herba Linderniae Crustaceaes, 17 parts of Semen Impatientis, 23 parts of Caulis Kadsurae Coccineae, 7 parts of Radix Ixorae Chinensiss, 7 parts of Clematis aethusifolia Turczs, 14 parts of Radix Tylophorae Yunnanensis and wear 16 parts, stone rattan.
5. the Chinese medicine as described in claims 1 to 3, is characterized in that, the ratio of weight and number of described each raw medicinal material of Chinese medicine is as follows: 18 parts of Radix Sarcococcae Ruscifoliae (Herba Sarcoclccae Ruscifoliae), 13 parts of Folium desmoris, 22 parts of Herba Peperomiae Dindygulensiss, 31 parts of Fomes Fomentarius, 7 parts of Herba Scutellariae Barbataes, 14 parts of Herba Pileae Scriptaes, 34 parts of Herba Linderniae Crustaceaes, 18 parts of Semen Impatientis, 21 parts of Caulis Kadsurae Coccineae, 8 parts of Radix Ixorae Chinensiss, 6 parts of Clematis aethusifolia Turczs, 12 parts of Radix Tylophorae Yunnanensis and wear 18 parts, stone rattan.
6. the Chinese medicine as described in claim 1 to 5, is characterized in that, when the dosage form of described Chinese medicine is capsule, its preparation method comprises the following steps:
The first step: each raw medicinal material of described Chinese medicine is mixed in proportion, adds the ethanol that the determining alcohol with respect to 5～7 times of mixture qualities is 85～95%, reflux 1～3 hour, extracts, and filters and obtains the first extracting solution; The medicinal residues that filter to obtain add the ethanol that the determining alcohol with respect to 3～5 times of medicinal residues quality is 85～95% again, and reflux 1～2 hour, extracts, and filters and obtains the second extracting solution; The first extracting solution and the second extracting solution are merged, and concentrating under reduced pressure is removed alcohol solvent, dry, obtains and gets dry extract;
Second step: the dry cream that the first step is obtained is placed in super micron mill to be pulverized 1～2 hour, pulverizes and sieves and obtains 300～400 object micropowders;
The 3rd step: the micropowders obtaining at second step adds the microcrystalline Cellulose with respect to 0.2～0.4 times of its quality, the starch of 0.1～0.3 times, the magnesium stearate of 0.01～0.03 times, mix processing, obtain capsule 's content, described Capsule content is incapsulated in housing, obtain capsule finished product.
7. the Chinese medicine as described in claim 1 to 5, is characterized in that, when the dosage form of described Chinese medicine is oral liquid, its preparation method comprises the following steps:
The first step: described raw medicinal material is mixed to the alcohol reflux that to add with respect to 3 times～5 times amount determining alcohols of mixture be 55%～65% 2 times～4 times, each 2 hours～3 hours, filter, filtrate merges, and reclaims ethanol, be concentrated into the mastic that 70 ℃ of relative densities are 1.30～1.32, standby;
Second step: 55 ℃～65 ℃ reduced vacuum of described mastic that the first step is obtained are dry, and powder gets dry extract;
The 3rd step: add ethanol in the described dried cream powder will second step obtaining, and obtain containing alcohol mastic, described is 65%～70% containing alcohol mastic containing alcohol amount; By described, containing alcohol mastic, carry out successively cold preservation processing, precipitation process, filtration treatment, recovery Ethanol Treatment, obtain dealcoholysis mastic, wherein, the cold preservation processing time is 30～40 hours;
The 4th step: will add cane sugar powder, active carbon in described dealcoholysis mastic, carry out successively heat treated, filtration treatment, dilution process, obtain semi-finished product; The weight ratio of described dealcoholysis mastic and described cane sugar powder is 1: 0.1～0.3; The weight ratio of described dealcoholysis mastic and described active carbon is 1: 0.001～0.002; The time of described heat treated is 20～40 minutes, and temperature is 100 ℃～110 ℃;
The 5th step: the described semi-finished product that again the 4th step obtained carry out filtration treatment, embedding processing, sterilization treatment successively, obtain described Chinese medicine oral liquid finished product.
8. a preparation method for Chinese medicine described in claim 1 to 5, is characterized in that, the dosage form of described Chinese medicine is capsule, and its preparation method comprises the following steps:
The first step: each raw medicinal material of described Chinese medicine is mixed in proportion, adds the ethanol that the determining alcohol with respect to 5～7 times of mixture qualities is 85～95%, reflux 1～3 hour, extracts, and filters and obtains the first extracting solution; The medicinal residues that filter to obtain add the ethanol that the determining alcohol with respect to 3～5 times of medicinal residues quality is 85～95% again, and reflux 1～2 hour, extracts, and filters and obtains the second extracting solution; The first extracting solution and the second extracting solution are merged, and concentrating under reduced pressure is removed alcohol solvent, dry, obtains and gets dry extract;
Second step: the dry cream that the first step is obtained is placed in super micron mill to be pulverized 1～2 hour, pulverizes and sieves and obtains 300～400 object micropowders;
The 3rd step: the micropowders obtaining at second step adds the microcrystalline Cellulose with respect to 0.2～0.4 times of its quality, the starch of 0.1～0.3 times, the magnesium stearate of 0.01～0.03 times, mix processing, obtain capsule 's content, described Capsule content is incapsulated in housing, obtain capsule finished product.
9. a preparation method for Chinese medicine described in claim 1 to 5, is characterized in that, the dosage form of described Chinese medicine is oral liquid, and its preparation method comprises the following steps:
The first step: described raw medicinal material is mixed to the alcohol reflux that to add with respect to 3 times～5 times amount determining alcohols of mixture be 55%～65% 2 times～4 times, each 2 hours～3 hours, filter, filtrate merges, and reclaims ethanol, be concentrated into the mastic that 70 ℃ of relative densities are 1.30～1.32, standby;
Second step: 55 ℃～65 ℃ reduced vacuum of described mastic that the first step is obtained are dry, and powder gets dry extract;
The 3rd step: add ethanol in the described dried cream powder will second step obtaining, and obtain containing alcohol mastic, described is 65%～70% containing alcohol mastic containing alcohol amount; By described, containing alcohol mastic, carry out successively cold preservation processing, precipitation process, filtration treatment, recovery Ethanol Treatment, obtain dealcoholysis mastic, wherein, the cold preservation processing time is 30～40 hours;
The 4th step: will add cane sugar powder, active carbon in described dealcoholysis mastic, carry out successively heat treated, filtration treatment, dilution process, obtain semi-finished product; The weight ratio of described dealcoholysis mastic and described cane sugar powder is 1: 0.1～0.3; The weight ratio of described dealcoholysis mastic and described active carbon is 1: 0.001～0.002; The time of described heat treated is 20～40 minutes, and temperature is 100 ℃～110 ℃;
The 5th step: the described semi-finished product that again the 4th step obtained carry out filtration treatment, embedding processing, sterilization treatment successively, obtain described Chinese medicine oral liquid finished product.
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