CN101167883A - Traditional Chinese medicine compound preparation for preventing gastric cancer metastasis and preparation method thereof - Google Patents
Traditional Chinese medicine compound preparation for preventing gastric cancer metastasis and preparation method thereof Download PDFInfo
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Abstract
The invention provides a traditional Chinese medicine compound medicament for preventing the metastasis of gastric cancer and process for preparation, wherein the traditional Chinese medicine compound medicament) is made from the raw traditional Chinese medicine materials with respective part by weight of 10-70 parts of astragalus root, 30-60 parts of psoralen, 20-40 parts of ligustrum japonicum, 20-40 parts of matrimony vine, and 10-30 parts of scrophularia root and has excellent effect to inhibit the metastasis of gastric cancer. The medicament method is that the raw traditional Chinese medicine materials with respective part by weight are mixed, and are immersed with 1-2 hours by adding 8-12 times amount water, and are extracted by hyperacoustic for 10-20 minutes, and are filtered, and the filter liquor is gathered. The filter residue is added with 4-8 times amount water, and is extracted by hyperacoustic for 5-15 minutes, and is filtered, and the filter liquor is gathered. The filter liquors of the three times are merged, and the dissolvent is evaporated reelingly and dry extract is made, and after put into bake oven to be fully baked under the temperature of 70-80DEG C, the invention is disintegrated to fines, and then the fines are added with various findings which are needed for preparing different medicament formulations to make the needed traditional Chinese medicine medicament formulations.
Description
Technical field
The invention belongs to the field of Chinese medicines, particularly compound Chinese medicinal preparation of a kind of anti-stomach cancer metastasis and preparation method thereof.
Background technology
Malignant tumor is commonly encountered diseases, the frequently-occurring disease of a class serious harm people ' s health and life.Wherein, gastric cancer is one of human comparatively common tumor, and its sickness rate height occupies first of digestive tract tumor, is the first place of various cancers at its mortality rate of China.It is about 150,000 that the number of gastric cancer is died from the whole nation every year, and China's gastric cancer mortality worldwide also belongs to higher area.
Stomach cancer cell shifts the same with other neoplasm metastasis, it is the process of a complexity, tumor cell is by breaking away from primary lesion, pass basement membrane and substrate enters blood circulation, carry out selective attachment with vascular endothelial cell then, pass basement membrane of blood vessel again and destroy extracellular matrix, and then enter the dystopy organ, proceed cell growth, division and new vessels and generate or the like, form metastatic lesion.The target spot that has a lot of treatments in the whole transfer process, but the complete mechanism of anti metastasis is also not exclusively clear, also needs further to inquire into and research.And the antineoplaston of Chinese medicine just is conceived to integral body, is comprehensive human body immunity improving power, improves high blood coagulation state and microcirculation disturbance, reduces thrombosis and chance occurs, alleviates tissue edema etc.Many researchs have proved that also Chinese medicine and effective ingredient thereof have good antitumor, the effect of anti metastasis, are one of important auxiliary treatment of traditional antitumor, anti metastasis treatment.
Chinese invention patent CN1457837A discloses a kind ofly has inhibiting Chinese medicine preparation to gastric cancer, and its weak point is that the transferance that resists gastric cancer do not mention.Chinese invention patent CN1394646A discloses a kind of anticancer Chinese powder medicine and preparation method thereof, and its effect is human body immunity improving and inhibition, dissolved cancer cell, and its weak point is whether resisting cancer metastasis also not mentioned.
Summary of the invention
The objective of the invention is to overcome the deficiencies in the prior art part, a kind of compound Chinese medicinal preparation of anti-stomach cancer metastasis is provided, this compound Chinese medicinal preparation is under the guidance of theory of Chinese medical science, and rational proportion, the synergism by each medical material makes it to suppressing stomach cancer metastasis good effect be arranged.
Another object of the present invention is to provide a kind of preparation method of compound Chinese medicinal preparation of anti-stomach cancer metastasis.
Purpose of the present invention is achieved through the following technical solutions: a kind of compound Chinese medicinal preparation of anti-stomach cancer metastasis, make by the raw material of Chinese medicine of following weight parts: 40～70 parts of the Radixs Astragali, 30～60 parts of Fructus Psoraleaes, 20～40 parts of Fructus Ligustri Lucidi, 20～40 parts of Fructus Lyciis, 10～30 parts of Radix Scrophulariaes.
The compound Chinese medicinal preparation of described anti-stomach cancer metastasis is preferably made by the raw material of Chinese medicine of following weight parts: 55 parts of the Radixs Astragali, 50 parts of Fructus Psoraleaes, 30 parts of Fructus Ligustri Lucidi, 30 parts of Fructus Lyciis, 20 parts of Radix Scrophulariaes.
The compound Chinese medicinal preparation of described anti-stomach cancer metastasis, the conventional oral formulations of its dosage form for adopting the Chinese medicine preparation conventional method to be prepared into is as tablet, capsule, oral liquid, electuary etc.
The preparation method of the compound Chinese medicinal preparation of described anti-stomach cancer metastasis comprises the steps:
(1) Radix Astragali, Fructus Psoraleae, Fructus Lycii, Radix Scrophulariae and Fructus Ligustri Lucidi are mixed according to described weight ratio, add 8～12 times of water gagings and soaked 1～2 hour, supersound extraction 10～30 minutes is filtered, and collects filtrate; Filtering residue adds 6～10 times of water gagings, and supersound extraction 10～20 minutes is filtered, and collects filtrate; Filtering residue adds 4～8 times of water gagings, and supersound extraction 5～15 minutes is filtered, and collects filtrate; Merge to merge three filtrates, rotary evaporation is flung to solvent and is made dry extract, and 70～80 ℃ are ground into fine powder after being baked to bone dry in baking oven.
The various conventional adjuvant that needs when (2) this fine powder being added the preparation different dosage form, method of Chinese medicinal routinely is prepared into required Chinese medicine preparation dosage form.
Described step is preferably mixed the Radix Astragali, Fructus Psoraleae, Fructus Lycii, Radix Scrophulariae and Fructus Ligustri Lucidi in (1) according to described weight ratio, add 10 times of water gagings and soaked 1.5 hours, and supersound extraction 20 minutes is filtered, and collects filtrate; Filtering residue adds 8 times of water gagings, and supersound extraction 15 minutes is filtered, and collects filtrate; Filtering residue adds 6 times of water gagings, and supersound extraction 10 minutes is filtered, and collects filtrate; Merge three times filtrate, be ground into fine powder after the lyophilization.
The compound Chinese medicinal preparation of anti-stomach cancer metastasis of the present invention selects the Radix Astragali, Fructus Psoraleae, Fructus Lycii, Radix Scrophulariae and Fructus Ligustri Lucidi to carry out the combined preparation active component.Wherein the Radix Astragali, Fructus Psoraleae, Fructus Ligustri Lucidi, Fructus Lycii have the effect of QI invigorating invigorating the liver and kidney, and Radix Scrophulariae has the effect of blood circulation promoting and blood stasis dispelling, removing heat from blood, detoxifcation, eliminating stasis to stop pain.Modern study shows that above-mentioned flavour of a drug all have antineoplastic action.The shared function that plays the inrigorating qi and promoting blood circulation blood stasis dispelling of above-mentioned five kinds of Chinese medicine plays the effect of anti-stomach cancer metastasis.
The present invention compared with prior art has following outstanding advantage:
Compound Chinese medicinal preparation of the present invention is under instruction of Chinese Medicine theory, at the patients with gastric cancer of " blood stasis due to qi deficiency " card, is that the rule of treatment is selected the medicine prescription with " inrigorating qi and promoting blood circulation blood stasis dispelling ", and this compound preparation has good effect to suppressing stomach cancer metastasis.
The specific embodiment
The present invention is described in further detail below in conjunction with embodiment, but the working of an invention mode is not limited thereto.
Embodiment 1
(1) takes by weighing each crude drug (is example with ten times of material proportional quantities) by following weight proportion
550 parts of the Radixs Astragali, 500 parts of Fructus Psoraleaes, 300 parts of Fructus Ligustri Lucidi, 300 parts of Fructus Lyciis, 200 parts of Radix Scrophulariaes, standby.
(2) Radix Astragali of above-mentioned weight proportion, Fructus Psoraleae, Fructus Lycii, Radix Scrophulariae and Fructus Ligustri Lucidi add 10 times of water gagings immersions 1.5 hours, and supersound extraction 20 minutes is filtered, and collects filtrate; Filtering residue adds 8 times of water gagings, and supersound extraction 15 minutes is filtered, and collects filtrate; Filtering residue adds 6 times of water gagings, supersound extraction 10 minutes.Merge three times filtrate, rotary evaporation is flung to solvent and is made dry extract, and 75 ℃ are baked to and are ground into fine powder (crossing 80 mesh sieves) behind the bone dry in baking oven.
(3) get 75 parts of above-mentioned segmentations, add 5 parts of starch, 4 parts of 8% starch slurries, 12.5 parts of dried starch, 0.4 part of magnesium stearate, above-mentioned mark is weight portion.The medicine segmentation mixes with starch, adds starch slurry and makes soft material, granulates with 14 mesh sieves, puts 70 ℃ of dry backs in 12 mesh sieve granulate, and behind adding dried starch and the magnesium stearate mixing, tabletting promptly obtains tablet.
Embodiment 2
(1) takes by weighing each crude drug (is example with ten times of material proportional quantities) by following weight proportion
400 parts of the Radixs Astragali, 300 parts of Fructus Psoraleaes, 200 parts of Fructus Ligustri Lucidi, 200 parts of Fructus Lyciis, 100 parts of Radix Scrophulariaes are standby.
(2) Radix Astragali of above-mentioned weight proportion, Fructus Psoraleae, Fructus Lycii, Radix Scrophulariae and Fructus Ligustri Lucidi add 8 times of water gagings immersions 1 hour, and supersound extraction 10 minutes is filtered, and collects filtrate; Filtering residue adds 6 times of water gagings, and supersound extraction 10 minutes is filtered, and collects filtrate; Filtering residue adds 4 times of water gagings, supersound extraction 10 minutes.Merge three times filtrate, rotary evaporation is flung to solvent and is made dry extract, and 70 ℃ are baked to and are ground into fine powder (crossing 80 mesh sieves) behind the bone dry in baking oven.
(3) get 75 parts of above-mentioned segmentations, add 5 parts of starch, 8 parts of 10% starch slurries, 10 parts of dried starch, above-mentioned mark is weight portion.The medicine segmentation mixes with starch, adds starch slurry and makes soft material, granulates with 14 mesh sieves, puts 80 ℃ of dry backs in 12 mesh sieve granulate, makes granule, mixing, and the snap fit capsule of packing into promptly gets capsule.
Embodiment 3
(1) takes by weighing each crude drug (is example with ten times of material proportional quantities) by following weight proportion
700 parts of the Radixs Astragali, 600 parts of Fructus Psoraleaes, 400 parts of Fructus Ligustri Lucidi, 400 parts of Fructus Lyciis, 300 parts of Radix Scrophulariaes are standby.
(2) Radix Astragali of above-mentioned weight proportion, Fructus Psoraleae, Fructus Lycii, Radix Scrophulariae and Fructus Ligustri Lucidi add 12 times of water gagings immersions 2 hours, and supersound extraction 30 minutes is filtered, and collects filtrate; Filtering residue adds 10 times of water gagings, and supersound extraction 20 minutes is filtered, and collects filtrate; Filtering residue adds 8 times of water gagings, supersound extraction 15 minutes.Merge three times filtrate, rotary evaporation is flung to solvent and is made dry extract, and 80 ℃ are baked to and are ground into fine powder (crossing 80 mesh sieves) behind the bone dry in baking oven.
(3) get 67 parts of above-mentioned segmentations, add 12 parts of starch, 8 parts of 10% starch slurries, 13 parts of dried starch, above-mentioned mark is weight portion.The medicine segmentation mixes with starch, adds starch slurry and makes soft material, granulates with 14 mesh sieves, puts 75 ℃ of dry backs in 12 mesh sieve granulate, and packing promptly gets this product granule.
Embodiment 4
(1) takes by weighing each crude drug (is example with ten times of material proportional quantities) by following weight proportion
600 parts of the Radixs Astragali, 400 parts of Fructus Psoraleaes, 300 parts of Fructus Ligustri Lucidi, 200 parts of Fructus Lyciis, 150 parts of Radix Scrophulariaes are standby.
(2) Radix Astragali of above-mentioned weight proportion, Fructus Psoraleae, Fructus Lycii, Radix Scrophulariae and Fructus Ligustri Lucidi add 10 times of water gagings immersions 1.5 hours, and supersound extraction 20 minutes is filtered, and collects filtrate; Filtering residue adds 8 times of water gagings, and supersound extraction 15 minutes is filtered, and collects filtrate; Filtering residue adds 6 times of water gagings, supersound extraction 10 minutes.Merge three times filtrate, rotary evaporation is flung to solvent and is made dry extract, and 75 ℃ are baked to and are ground into fine powder (crossing 80 mesh sieves) behind the bone dry in baking oven.
(3) get above-mentioned fine powder 60g and be dissolved in the 500ml distilled water, stir and make its dissolving, filter, and pass through the filter adding distil water, promptly get this product oral liquid to 1000ml.
Embodiment 5
Chinese medicine compound of the present invention is to the influence of FC stomach cancer metastasis suppression ratio
Experiment material: 615 mices, the strain of gastric cancer FC tumor.
Experimental technique and result: under aseptic condition, make the FC cell suspension of 1:3 dilution, cell concentration is 2 * 10
6/ ml, the subcutaneous injection of every Mus axillary fossa 0.2ml was divided into 4 groups at random by body weight after 24 hours: matched group and high, medium and low dosage group, 10 every group, male and female half and half.
Chinese medicine compound of the present invention is concentrated into respective concentration after adopting the ultrasonic method effective component extracting.The various dose group comprises high dose group (40g/kg), middle dosage group (20g/kg), low dose group (10g/kg).Every day gastric infusion once, continuous 10 days.Matched group filling stomach gives equivalent and gets normal saline.Put to death mice next day in drug withdrawal, weigh, peel off lungs and shift tuberosity, calculate gastric cancer lung metastasis inhibition rate.The results are shown in Table 1, Chinese medicine compound of the present invention as can be seen from Table 1 has good effect to the transfer that suppresses the gastric cancer Mouse Gastric Cancer.Low-dose drugs is 50% to FC stomach cancer metastasis suppression ratio, high dose medicament to FC stomach cancer metastasis suppression ratio up to 90%.
Embodiment 6
Chinese medicine compound of the present invention is to the influence of FC gastric cancer mouse tumor metastasis inhibition rate
Laboratory animal: inbred line 615 mices, male, 6～8 ages in week, body weight 18～22g.
Experimental technique and result: get and transplant 8～10 days portable preceding squamous cell carcinoma of stomach (FC) tissue in back, be prepared into 1 * 10
10The cell suspension of/L, in the right axil subcutaneous injection of mice cell suspension 0.2ml/ only.Be divided into 4 groups after the strain of mouse inoculation tumor at random and comprise matched group and high, medium and low dosage group, 10 every group.
Chinese medicine compound of the present invention is concentrated into respective concentration after adopting the ultrasonic method effective component extracting.The various dose group comprises high dose group (40g/kg), middle dosage group (20g/kg), low dose group (10g/kg).Every treated animal is second day difference gastric infusion after connecing tumor, and be administered once every day, and in continuous 3 weeks, matched group filling stomach gives equivalent and gets normal saline.Experiment finishes back anatomy experiment mice, takes out lungs, the total metastasis number of counting pulmonary.Metastasis is ecru, edge polishing, similar round tuberosity.Metastasis inhibition rate=(blank group metastasis number-administration group metastasis number)/blank group metastasis number * 100%.The results are shown in Table 2, Chinese medicine compound of the present invention as can be seen from Table 2 has good effect to the transfer that suppresses the gastric cancer Mouse Gastric Cancer.With the increase of dosage, the tumor nodule number of transfer reduces.Low-dose drugs is 20.5% to FC gastric cancer mouse tumor metastasis inhibition rate, and high dose medicament is 54.5% to FC gastric cancer mouse tumor metastasis inhibition rate.
Table 1 Chinese medicine compound is to the result of FC stomach cancer metastasis suppression ratio influence
| Grouping | Dosage (g/kg) | Number of animals | Shift number | The rate of transform (%) | The metastasis inhibition rate |
| Dosage group high dose group in the matched group low dose group | 0 10 20 40 | 10 10 10 10 | 10/10 5/10 4/10 1/10 | 100 50 40 10 | - 50 60 90 |
Table 2 Chinese medicine compound is to the influence of FC gastric cancer mouse tumor metastasis inhibition rate
| Grouping | Dosage (g/kg) | Number of animals | Tumor tuberosity number (individual) | Metastasis inhibition rate (%) |
| Dosage group high dose group in the matched group low dose group | 0 10 20 40 | 10 10 10 10 | 15.6±2.6 12.4±2.1 10.2±1.9 7.1±1.7 | - 20.5 34.6 54.5 |
The foregoing description is a preferred implementation of the present invention; but embodiments of the present invention are not restricted to the described embodiments; other any do not deviate from change, the modification done under spirit of the present invention and the principle, substitutes, combination, simplify; all should be the substitute mode of equivalence, be included within protection scope of the present invention.
Claims (6)
1. the compound Chinese medicinal preparation of an anti-stomach cancer metastasis, it is characterized in that: the raw material of Chinese medicine by following weight parts is made: 40～70 parts of the Radixs Astragali, 30～60 parts of Fructus Psoraleaes, 20～40 parts of Fructus Ligustri Lucidi, 20～40 parts of Fructus Lyciis, 10～30 parts of Radix Scrophulariaes.
2. the compound Chinese medicinal preparation of anti-stomach cancer metastasis according to claim 1, it is characterized in that: the raw material of Chinese medicine by following weight parts is made: 55 parts of the Radixs Astragali, 50 parts of Fructus Psoraleaes, 30 parts of Fructus Ligustri Lucidi, 30 parts of Fructus Lyciis, 20 parts of Radix Scrophulariaes.
3. the compound Chinese medicinal preparation of anti-stomach cancer metastasis according to claim 1 is characterized in that: the conventional oral formulations of its dosage form for adopting the Chinese medicine preparation conventional method to be prepared into.
4. the compound Chinese medicinal preparation of anti-stomach cancer metastasis according to claim 3, it is characterized in that: described conventional oral formulations is tablet, capsule, oral liquid or electuary.
5. the preparation method of the compound Chinese medicinal preparation of anti-stomach cancer metastasis according to claim 1 is characterized in that comprising the steps:
(1) Radix Astragali, Fructus Psoraleae, Fructus Lycii, Radix Scrophulariae and Fructus Ligustri Lucidi are mixed by described weight ratio, add 8～12 times of water gagings and soaked 1～2 hour, supersound extraction 10～30 minutes is filtered, and collects filtrate; Filtering residue adds 6～10 times of water gagings, and supersound extraction 10～20 minutes is filtered, and collects filtrate; Filtering residue adds 4～8 times of water gagings, and supersound extraction 5～15 minutes is filtered, and collects filtrate; Merge three times filtrate, rotary evaporation is flung to solvent and is made dry extract, and 70～80 ℃ are ground into fine powder after being baked to bone dry in baking oven;
The various conventional adjuvant that needs when (2) this fine powder being added the preparation different dosage form, method of Chinese medicinal routinely is prepared into required Chinese medicine preparation dosage form.
6. the preparation method of the compound Chinese medicinal preparation of anti-stomach cancer metastasis according to claim 5, it is characterized in that: in the described step (1) with the mixing of the Radix Astragali, Fructus Psoraleae, Fructus Lycii, Radix Scrophulariae and Fructus Ligustri Lucidi according to described weight ratio, adding 10 times of water gagings soaked 1.5 hours, supersound extraction 20 minutes, filter, collect filtrate; Filtering residue adds 8 times of water gagings, and supersound extraction 15 minutes is filtered, and collects filtrate; Filtering residue adds 6 times of water gagings, and supersound extraction 10 minutes is filtered, and collects filtrate; Merge three times filtrate, rotary evaporation is flung to solvent and is made dry extract, and 70～80 ℃ are ground into fine powder after being baked to bone dry in baking oven.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104720050A (en) * | 2013-12-24 | 2015-06-24 | 曾正 | Traditional Chinese medicine vinegar agent for treating female kidney deficiency |
| CN105168658A (en) * | 2015-10-08 | 2015-12-23 | 谭真 | Traditional Chinese medicine preparation for treating stomach cancer and preparation method of traditional Chinese medicine preparation |
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2007
- 2007-11-06 CN CN200710031277A patent/CN100584317C/en not_active Expired - Fee Related
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104720050A (en) * | 2013-12-24 | 2015-06-24 | 曾正 | Traditional Chinese medicine vinegar agent for treating female kidney deficiency |
| CN105168658A (en) * | 2015-10-08 | 2015-12-23 | 谭真 | Traditional Chinese medicine preparation for treating stomach cancer and preparation method of traditional Chinese medicine preparation |
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