CN102370886B - Traditional Chinese medicinal composition for resisting breast cancer metastasis - Google Patents
Traditional Chinese medicinal composition for resisting breast cancer metastasis Download PDFInfo
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- CN102370886B CN102370886B CN 201010257844 CN201010257844A CN102370886B CN 102370886 B CN102370886 B CN 102370886B CN 201010257844 CN201010257844 CN 201010257844 CN 201010257844 A CN201010257844 A CN 201010257844A CN 102370886 B CN102370886 B CN 102370886B
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Abstract
The invention provides a traditional Chinese medicinal composition for resisting breast cancer metastasis. The traditional Chinese medicinal composition is prepared by the following Chinese medicinal materials by weight: 10-60 parts of white ginseng, 5-30 parts of morinda officinalis, 10-50 parts of lychee seeds, 10-50 parts of rhizoma polygonati, 10-40 parts of manyprickle acanthopanax, and 10-50 parts of fructus liquidambaris. The traditional Chinese medicinal composition provided in the invention can resist breast cancer metastasis.
Description
Technical field
The present invention relates to the Chinese medicine composition that a kind of anti-breast cancer shifts, belong to the field of Chinese medicines.
Technical background
Malignant tumor is commonly encountered diseases, the frequently-occurring disease of a class serious harm people ' s health and life.Wherein breast carcinoma is one of human comparatively common tumor, its sickness rate height, for the female tumor morbidity is first, this illness is one of main illness of serious harm young women health and lives at present, and the number of national annual New Development breast carcinoma is about more than 1,000,000.
Breast cancer cell shifts the same with other neoplasm metastasis, it is the process of a complexity, tumor cell is by breaking away from primary lesion, pass basement membrane and substrate enters blood circulation, carry out selective attachment with vascular endothelial cell then, pass basement membrane of blood vessel again and destroy extracellular matrix, and then enter the dystopy organ, proceed cell growth, division and new vessels and generate or the like, form metastatic lesion.The target spot that has a lot of treatments in the whole transfer process, but the complete mechanism of anti metastasis is also not exclusively clear, also needs further to inquire into and research.And the antineoplaston of Chinese medicine just is conceived to integral body, is comprehensive human body immunity improving power, improves high blood coagulation state and microcirculation disturbance, reduces thrombosis and chance occurs, alleviates tissue edema etc.Many researchs have proved that also Chinese medicine and effective ingredient thereof have good antitumor, the effect of anti metastasis, are one of important auxiliary treatment of traditional antitumor, anti metastasis treatment.
The present invention is directed to blood stasis due to qi deficiency state behind the common postoperative of patient with breast cancer, the chemicotherapy, with " QI invigorating blood stasis dispelling " is rule of treatment principle, having selected Chinese crude drug Radix Ginseng, Radix Morindae Officinalis, Semen Litchi, Rhizoma Polygonati, Radix Et Caulis Acanthopanacis Senticosi, Fructus Liquidambaris is the raw material prescription, is prepared into to play the Chinese medicine preparation that anti-breast cancer shifts.
Chinese invention patent publication number CN1249946 discloses a kind of Chinese medicine composition for the treatment of breast carcinoma and preparation method thereof, is raw material by Herba Ipomoeae Cairicae; Chinese invention patent publication number CN1410097 discloses a kind of Chinese patent medicine for the treatment of breast carcinoma, is made by nine flavor Chinese herbal medicine such as Fructus Trichosanthis, big gun Squama Manis, Herba Taraxaci, Colla Cornus Cervi, Rhizoma Paridis, Pseudobulbus Cremastrae seu Pleiones, Borax, Huechys sanguinea De Geer., sea clam powder.Chinese invention patent publication number CN1872284 discloses a kind of Chinese medicine for the treatment of breast carcinoma, is made up of Semen Coicis, Ganoderma, Semen Vaccariae, Rhizoma Cyperi, Pseudobulbus Cremastrae Seu Pleiones and Gekko Swinhonis; These inventions are treatment breast carcinoma, play blood circulation promoting and blood stasis dispelling, and eliminating stagnation dispersing tumor effect has obvious curative effects to breast carcinoma.But the transferance to anti-breast cancer is not mentioned.
Summary of the invention:
The Chinese medicine composition that the object of the invention provides a kind of anti-breast cancer to shift is guidance with the Chinese medicine basic theories, by the rational proportion of each Chinese crude drug, plays the effect that suppresses Metastasis in Breast Cancer.
The Chinese medicine preparation that anti-breast cancer of the present invention shifts selects Radix Ginseng, Radix Morindae Officinalis, Semen Litchi, Rhizoma Polygonati, Radix Et Caulis Acanthopanacis Senticosi, Fructus Liquidambaris to carry out the combined preparation active component.Wherein Radix Ginseng, Radix Morindae Officinalis, Rhizoma Polygonati have QI invigorating tonifying YIN effect, and Semen Litchi, Radix Et Caulis Acanthopanacis Senticosi, Fructus Liquidambaris have acupuncture-stimulating blood stasis dispersing, detoxicating and resolving stagnation of pathogens effect.The shared function that plays the QI invigorating blood stasis dispelling of above-mentioned five kinds of Chinese medicine plays the effect that anti-breast cancer shifts.
Characteristics of the present invention are: this invention Chinese medicine composition is at the empty stasis of blood state behind the women with breast cancer chemoradiotherapy, is that the rule of treatment selects the medicine prescription to suppress Metastasis in Breast Cancer with the QI invigorating blood stasis dispelling.
The raw material consumption of preparation medicine activity component of the present invention is: Radix Ginseng 10-60 part, Radix Morindae Officinalis 5-30 part, Semen Litchi 10-50 part, Rhizoma Polygonati 10-50 part, Radix Et Caulis Acanthopanacis Senticosi 10-40 part, Fructus Liquidambaris 10-50 part; Be preferably 45 parts of Radix Ginseng, 9 parts of Radix Morindae Officinaliss, 12 parts of Semen Litchis, 18 parts of Rhizoma Polygonatis, 12 parts of Radix Et Caulis Acanthopanacis Senticosis, 9 parts of Fructus Liquidambaris.
Chinese medicine composition of the present invention is made by following method:
Radix Ginseng, Radix Morindae Officinalis, Semen Litchi, Rhizoma Polygonati, Radix Et Caulis Acanthopanacis Senticosi and Fructus Liquidambaris are mixed according to above-mentioned weight ratio, add 6-10 times of water gaging and soaked 1-2 hour, preferred 8 times of water gagings soaked 1.5 hours, and decocting extracted 0.5-3 hour, and preferred 1.5 hours, filter, collect filtrate; Filtering residue adds 5-8 times of water gaging, preferred 6 times of water gagings, and decocting extracted 0.5-2 hour, and preferred 1 hour, filter, collect filtrate, merging filtrate; Filtrate evaporation is flung to liquid and is prepared into dry extract, and 80 ℃ are ground into fine powder after being baked to bone dry in baking oven.
Above-mentioned fine powder can add the various conventional adjuvant for preparing different dosage form, and method of Chinese medicinal routinely is prepared into the common Chinese medicine preparation formulation, as tablet, capsule, oral liquid, electuary etc.
The invention will be further elaborated below in conjunction with embodiment, but be not limited to this.
Embodiment 1 preparation tablets of the present invention (is example with ten times of material proportional quantities)
1. take by weighing each crude drug by following weight proportion
450 parts of Radix Ginseng, 90 parts of Radix Morindae Officinaliss, 120 parts of Semen Litchis, 180 parts of Rhizoma Polygonatis, 120 parts of Radix Et Caulis Acanthopanacis Senticosis, 90 parts of Fructus Liquidambaris are standby.
2. above-mentioned weight ratio is mixed, and adds 8 times of water gagings and soaks 1.5 hours, and decocting extracted 1.5 hours, filtered, and collected filtrate; Filtering residue adds 6 times of water gagings, and decocting extracted 1 hour, filters, and collects filtrate, merging filtrate; Filtrate evaporation is flung to liquid and is prepared into dry extract, and 80 ℃ are ground into fine powder after being baked to bone dry in baking oven.
3. above-mentioned fine powder adds adjuvant and makes granule, drying, and tabletting is promptly.
The influence that experimental example 1 Chinese medicine composition of the present invention shifts mouse breast cancer tumour
Mouse breast cancer modelling: get well-grown 4T1 breast carcinoma solid tumor that goes down to posterity, prepare tumor cell suspension, transfer cell number 5 * 10 with normal saline
6Individual cell/ml only is inoculated under 40 BALB/c mouse mammary fat pad by 0.1ml/, and mice is divided into 4 groups at random, and 10 every group, treatment by the following method.
Chinese medicine composition dosage group of the present invention comprises high dose group (20g/kg), middle dosage group (10g/kg), low dose group (5g/kg); Every day gastric infusion once, continuous 14 days; Matched group gives the equivalent normal saline, puts to death mice next day in drug withdrawal, weighs, and peels off lungs and shifts tuberosity, calculates breast carcinoma lung metastasis inhibition rate, the results are shown in following table.
Claims (3)
1. the Chinese medicine composition that shifts of an anti-breast cancer, it is characterized in that: the raw material of Chinese medicine by following weight parts is formed: Radix Ginseng 10-60 part, Radix Morindae Officinalis 5-30 part, Semen Litchi 10-50 part, Rhizoma Polygonati 10-50 part, Radix Et Caulis Acanthopanacis Senticosi 10-40 part, Fructus Liquidambaris 10-50 part.
2. according to the Chinese medicine composition of the described anti-breast cancer transfer of claim 1, it is characterized in that: the raw material of Chinese medicine by following weight parts is formed: 45 parts of Radix Ginsengs, 9 parts of Radix Morindae Officinaliss, 12 parts of Semen Litchis, 18 parts of Rhizoma Polygonatis, 12 parts of Radix Et Caulis Acanthopanacis Senticosis, 9 parts of Fructus Liquidambaris.
3. according to claim 1, the preparation method of 2 described Chinese medicine compositions, its preparation process is as follows:
(1) Radix Ginseng, Radix Morindae Officinalis, Semen Litchi, Rhizoma Polygonati, Radix Et Caulis Acanthopanacis Senticosi and Fructus Liquidambaris are mixed according to above-mentioned weight ratio, add 6-10 times of water gaging and soaked 1-2 hour, decocting extracted 0.5-3 hour, filtered, and collected filtrate; Filtering residue adds 5-8 times of water gaging, and decocting extracted 0.5-2 hour, filters, and collects filtrate; Merging filtrate.
(2) filtrate evaporation is flung to liquid and is prepared into dry extract, and 80 ℃ are ground into fine powder after being baked to bone dry in baking oven.
The various conventional adjuvant of needs when (3) above-mentioned fine powder can add the preparation different dosage form, method of Chinese medicinal routinely is prepared into the common Chinese medicine preparation formulation.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201010257844 CN102370886B (en) | 2010-08-18 | 2010-08-18 | Traditional Chinese medicinal composition for resisting breast cancer metastasis |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201010257844 CN102370886B (en) | 2010-08-18 | 2010-08-18 | Traditional Chinese medicinal composition for resisting breast cancer metastasis |
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| Publication Number | Publication Date |
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| CN102370886A CN102370886A (en) | 2012-03-14 |
| CN102370886B true CN102370886B (en) | 2013-07-31 |
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| CN 201010257844 Expired - Fee Related CN102370886B (en) | 2010-08-18 | 2010-08-18 | Traditional Chinese medicinal composition for resisting breast cancer metastasis |
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101670071A (en) * | 2009-09-25 | 2010-03-17 | 卢速江 | Traditional Chinese medicine preparation for treating cancer and preparation method thereof |
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101670071A (en) * | 2009-09-25 | 2010-03-17 | 卢速江 | Traditional Chinese medicine preparation for treating cancer and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 谭开基，曹洋，黎壮伟.陈锐深辨治晚期乳腺癌的方法与思路.《上海中医药杂志》.2005,第39卷(第7期),17－18. * |
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| CN102370886A (en) | 2012-03-14 |
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