CN101322788B - Chinese medicine for treating vitiligo and preparation - Google Patents
Chinese medicine for treating vitiligo and preparation Download PDFInfo
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- CN101322788B CN101322788B CN2008101384978A CN200810138497A CN101322788B CN 101322788 B CN101322788 B CN 101322788B CN 2008101384978 A CN2008101384978 A CN 2008101384978A CN 200810138497 A CN200810138497 A CN 200810138497A CN 101322788 B CN101322788 B CN 101322788B
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Abstract
The invention belongs to the field of Chinese traditional medicine, in particular relates to a traditional Chinese medicine for treating vitiligo and a preparation method thereof. The traditional Chinese medicine of the invention is prepared from 12 Chinese medicinal herbs such as fructus psoraleae, radix astragali, angelica, radix salviae miltiorrhizae, safflower, rhizoma ligustici wallichii, stir-baked semen persicae, rhizoma cyperi, purple gromwell root, caltrop, cortex dictamni and gentian. The Chinese medicinal herbs are compatible and bring out the best in each other, have the efficacy of nourishing and activating blood, dispelling wind and dredging channels, and regulation of qi and blood. The traditional Chinese medicine of the invention has obvious effect on promoting the proliferation of melanoma cells, can obviously improve the activity of tyrosinase in cells, promote the synthesis of melanin, and inhibit the immunologic function of organisms. The clinical curative effect observation further indicates that the traditional Chinese medicine has the advantages of high clinical curative effect, quick action, short course of treatment, and no obvious toxic and side effect.
Description
Technical field
The invention belongs to the field of Chinese medicines, relate in particular to a kind of Chinese medicine and preparation method for the treatment of vitiligo.
Background technology
Chinese medicine also is called vitiligo leucoderma, vitiligo, white erosion, the Chinese medicine vitiligo: Chinese medicine is thought that this disease is many and is fought in skin because of aversion to wind, qi-blood disharmony, the not flourish skin of blood and falling ill, " Yizong Jinjian surgery heart method " record: vitiligo is due to " ailment said due to cold or exposure is fought mutually in skin, cause make qi-blood disharmony ".Though it is multiple that the cause of disease of primary disease has, interior traumatic condition will, depression of liver-QI, qi-blood disharmony are felt ailment said due to cold or exposure again, are fought in skin, cause make qi-blood disharmony, qi depression to blood stasis, the not flourish skin of blockage of main and collateral channels, blood, and send out primary disease is the main pathogenesis of primary disease.Control suitable nourshing blood and promoting blood circulation, dispelling wind collateral dredging, QI and blood regulating.
Western modern medicine treatment vitiligo: vitiligo (claims leukoderma again, vitiligo) be a kind of acquired, limitation or general property depigmentation of skin, be a kind ofly to take off with skin pigment that to lose be the dermatosis chronic disease of feature, easily diagnosis and refractory are the advanced subject of contemporary medical science research more.Because of its sickness rate increases year by year, though not unhealthful, bring considerable influence for patient's social activity, life, be regarded as current " not dead cancer ", conquering " white evil spirit " has become one of urgent task of medical educational circles.Leukodermic pathogeny is not illustrated as yet fully, and the cause of disease is still not fully aware of, does not still have satisfied specific medicament at present, and majority can only reach short term effect.
Summary of the invention
The present invention has overcome above-mentioned the deficiencies in the prior art, and a kind of Chinese medicine and preparation method for the treatment of vitiligo is provided.The Chinese medicine of treatment vitiligo of the present invention, be prepared from by following component, all in weight portion: 11.2～20.8 parts of Fructus Psoraleaes, 5.6～10.4 parts of the Radixs Astragali, 5.6～10.4 parts of Radix Angelicae Sinensis, 5.6～10.4 parts of Radix Salviae Miltiorrhizaes, 5.6～10.4 parts on Flos Carthami, 5.6～10.4 parts of Rhizoma Chuanxiongs, 2.8～5.2 parts of Semen Persicae (parched)s, 4.2～7.8 parts of Rhizoma Cyperis, 4.2～7.8 parts of Radix Arnebiae (Radix Lithospermi)s, 12.6～23.4 parts of Fructus Tribulis, 4.2～7.8 parts of Cortex Dictamni, 2.8～5.2 parts of Radix Gentianae.
The Chinese medicine of treatment vitiligo of the present invention, be prepared from by following component, all in weight portion: 12 parts of Fructus Psoraleaes, 6 parts of the Radixs Astragali, 6 parts of Radix Angelicae Sinensis, 6 parts of Radix Salviae Miltiorrhizaes, 6 parts on Flos Carthami, 10 parts of Rhizoma Chuanxiongs, 5 parts of Semen Persicae (parched)s, 7 parts of Rhizoma Cyperis, 7 parts of Radix Arnebiae (Radix Lithospermi)s, 22 parts of Fructus Tribulis, 6 parts of Cortex Dictamni, 4 parts of Radix Gentianae.
The Chinese medicine of treatment vitiligo of the present invention, be prepared from by following component, all in weight portion: 12 parts of Fructus Psoraleaes, 6 parts of the Radixs Astragali, 6 parts of Radix Angelicae Sinensis, 6 parts of Radix Salviae Miltiorrhizaes, 6 parts on Flos Carthami, 10 parts of Rhizoma Chuanxiongs, 5 parts of Semen Persicae (parched)s, 7 parts of Rhizoma Cyperis, 7 parts of Radix Arnebiae (Radix Lithospermi)s, 21 parts of Fructus Tribulis, 7 parts of Cortex Dictamni, 5 parts of Radix Gentianae.
The Chinese medicine of treatment vitiligo of the present invention, be prepared from by following component, all in weight portion: 12 parts of Fructus Psoraleaes, 6 parts of the Radixs Astragali, 6 parts of Radix Angelicae Sinensis, 10 parts of Radix Salviae Miltiorrhizaes, 10 parts on Flos Carthami, 10 parts of Rhizoma Chuanxiongs, 5 parts of Semen Persicae (parched)s, 7 parts of Rhizoma Cyperis, 7 parts of Radix Arnebiae (Radix Lithospermi)s, 20 parts of Fructus Tribulis, 7 parts of Cortex Dictamni, 5 parts of Radix Gentianae.
Chinese medicine of the present invention is mainly formed by Fructus Psoraleae, the Radix Astragali, Radix Angelicae Sinensis, Radix Salviae Miltiorrhizae, Flos Carthami, Rhizoma Chuanxiong, Semen Persicae (parched), Rhizoma Cyperi, Radix Arnebiae (Radix Lithospermi), Fructus Tribuli, Cortex Dictamni, Radix Gentianae 12 flavor raw material of Chinese medicine processing and refinings, and its dosage form comprises capsule, tablet and granule.Prescription is separated: Fructus Psoraleae, the Radix Astragali, Radix Angelicae Sinensis, Radix Salviae Miltiorrhizae four flavor Chinese medicine benefiting QI and nourishing blood are invigorated blood circulation and are monarch drug altogether in the side; Flos Carthami, Rhizoma Chuanxiong, Semen Persicae (parched), Rhizoma Cyperi, Radix Arnebiae (Radix Lithospermi) Chinese medicine of the five flavours dispelling wind collateral dredging, QI and blood regulating are ministerial drug altogether; Coating dampness removing in Fructus Tribuli, shaggy-fruited dittany two flavors, dispeling the wind is adjuvant drug altogether; Radix Gentianae suppressing the hyperactive liver Shu Yu, removing pathogenic heat from blood and toxic substance from the body are messenger drug.All medicine compatibilities gather the effect of nourshing blood and promoting blood circulation, dispelling wind collateral dredging, QI and blood regulating altogether, and Chinese medicine cures mainly leucoderma or/and vitiligo, white erosion, and western medicine is applicable to vitiligo or/and leukoderma.
The Chinese medicine of treatment vitiligo of the present invention, its preparation method is as follows:
(1) get 20～60% dry sterilizations of Radix Salviae Miltiorrhizae total amount by the said components weight portion, be ground into fine powder, sieve, standby;
(2) get remaining Radix Salviae Miltiorrhizae and by the composition weight number get Fructus Psoraleae etc. all the other ten simply Chinese medicine decoct with water and extract three times, the decocting that adds for the first time 4～7 times of amounts of whole extraction medical material weight boiled 2 hours, adding for the second time 3～6 times of water gagings of whole extraction medical material weight decocted 1.5 hours, adding 2～4 times of water gagings of whole extraction medical material weight for the third time decocted 1.0 hours, collecting decoction filters or/and leave standstill;
(3) get filtrate or/and supernatant is condensed into thick paste, drying is ground into fine powder, sieves;
(4) add above-mentioned Radix Salviae Miltiorrhizae fine powder mixing, add or do not add pharmaceutic adjuvant, granulate or do not granulate, be packed into capsule and promptly get capsule; Or an amount of compacting of granulating or do not granulate of interpolation pharmaceutic adjuvant promptly gets tablet in flakes; Or add pharmaceutic adjuvant and make granule in right amount and promptly get granule.
Pharmaceutic adjuvant is generally: starch, dextrin, lactose, microcrystalline Cellulose, sucrose, stearic acid, magnesium stearate etc., its kind and consumption are the amount doesn't matter according to preparation purpose and arts demand.
Pharmacodynamic study
Adopt single at random blind method to carry out clinical observation on the therapeutic effect to treatment by Chinese herbs vitiligo of the present invention.Clinical data: treatment by Chinese herbs group 109 examples of the present invention, wherein male 46 examples, women 63 examples, at minimum 18 years old of age, maximum 59 years old, 33.25 ± 10.97 years old mean age, the course of disease 1 year was with interior 46 examples, 1～3 year 38 example, 25 examples more than 3 years; The clinical diagnosis typing, general property 10 example, limitation 26 examples, sporadic 25 examples, acra 7 examples, Combination 14 examples, neuroganglion segment type 27 examples.Observational technique: adopt open trial to observe, disease situation of change before and after the record patient medication is carried out the rank scores statistics, carries out clinical observation and record weekly once, and all do routine blood test and hepatic and renal function inspection, the untoward reaction that observation may occur in the treatment front and back; 4 weeks were a course of treatment, added up curative effect after observing two courses of treatment continuously.Therapeutic outcome: Chinese medicine of the present invention has remarkable therapeutical effect to vitiligo (curing mainly blood deficiency and blood stasis, qi-blood disharmony card), and clinical recovery rate 34.77%, obvious effective rate 49.54%, total effective rate are 87.16%.Conclusion: Chinese medicine of the present invention has remarkable therapeutical effect to vitiligo, and treatment by Chinese herbs group clinical efficacy of the present invention is better than oral vitiligo capsule matched group.Untoward reaction: do not observe serious adverse reaction, routine blood test and the no abnormal change of hepatic and renal function illustrate that Chinese medicine of the present invention is safe and reliable before and after all patient treatments, and untoward reaction is very little.
Beneficial effect of the present invention is: the effect that the present invention is useful is a kind of Chinese medicine, it mainly is made up of Fructus Psoraleae, the Radix Astragali, Radix Angelicae Sinensis, Radix Salviae Miltiorrhizae, Flos Carthami, Rhizoma Chuanxiong, Semen Persicae (parched), Rhizoma Cyperi, Radix Arnebiae (Radix Lithospermi), Fructus Tribuli, Cortex Dictamni, Radix Gentianae 12 flavor raw material of Chinese medicine, all medicine compatibilities, bring out the best in each other, gather the effect of nourshing blood and promoting blood circulation, dispelling wind collateral dredging, QI and blood regulating altogether.Chinese medicine of the present invention has significantly short proliferation function to melanoma cell, and can significantly increase intracellular tyrosine enzymatic activity, melanin formation promoting, inhibition body's immunity.Clinical observation on the therapeutic effect shows that further the present invention has advantages such as clinical efficacy height, instant effect, short treating period, no obvious toxic-side effects, is taking the course of its own aspect the treatment by Chinese herbs vitiligo, is the leukodermic good medicine of treatment.
The specific embodiment
Mode below by embodiment further specifies the present invention.
Embodiment 1
The Chinese medicine of treatment vitiligo of the present invention is prepared from by following component, all in weight portion:
12 parts of Fructus Psoraleaes, 6 parts of the Radixs Astragali, 6 parts of Radix Angelicae Sinensis, 6 parts of Radix Salviae Miltiorrhizaes, 6 parts on Flos Carthami, 10 parts of Rhizoma Chuanxiongs, 5 parts of Semen Persicae (parched)s, 7 parts of Rhizoma Cyperis, 7 parts of Radix Arnebiae (Radix Lithospermi)s, 22 parts of Fructus Tribulis, 6 parts of Cortex Dictamni, 4 parts of Radix Gentianae.Preparation method is as follows:
(1) Radix Salviae Miltiorrhizae 6Kg gets 20～60% dry sterilizations of its total amount, is ground into fine powder, sieves, and is standby;
(2) get remaining Radix Salviae Miltiorrhizae and Fructus Psoraleae 12Kg, Radix Astragali 6Kg, Radix Angelicae Sinensis 6Kg, Radix Salviae Miltiorrhizae 6Kg, Flos Carthami 6Kg, Rhizoma Chuanxiong 10Kg, Semen Persicae (parched) 5Kg, Rhizoma Cyperi 7Kg, Radix Arnebiae (Radix Lithospermi) 7Kg, Fructus Tribuli 22Kg, Cortex Dictamni 6Kg, Radix Gentianae 4Kg, decoct with water and extract three times, the decocting that adds for the first time 4～7 times of amounts of whole extraction medical material weight boiled 2 hours, adding for the second time 3～6 times of water gagings of whole extraction medical material weight decocted 1.5 hours, adding 2～4 times of water gagings of whole extraction medical material weight for the third time decocted 1.0 hours, collecting decoction filters or/and leave standstill;
(3) get filtrate or/and supernatant is condensed into thick paste, drying is ground into fine powder, sieves;
(4) add above-mentioned Radix Salviae Miltiorrhizae fine powder mixing, add or do not add pharmaceutic adjuvant, granulate or do not granulate, be packed into capsule and promptly get capsule; Or an amount of compacting of granulating or do not granulate of interpolation pharmaceutic adjuvant promptly gets tablet in flakes; Or add pharmaceutic adjuvant and make granule in right amount and promptly get granule.
Embodiment 2
The Chinese medicine of treatment vitiligo of the present invention is prepared from by following component, all in weight portion:
12 parts of Fructus Psoraleaes, 6 parts of the Radixs Astragali, 6 parts of Radix Angelicae Sinensis, 6 parts of Radix Salviae Miltiorrhizaes, 6 parts on Flos Carthami, 10 parts of Rhizoma Chuanxiongs, 5 parts of Semen Persicae (parched)s, 7 parts of Rhizoma Cyperis, 7 parts of Radix Arnebiae (Radix Lithospermi)s, 21 parts of Fructus Tribulis, 7 parts of Cortex Dictamni, 5 parts of Radix Gentianae.
Other component batching processing and preparation method are with embodiment 1.
Embodiment 3
The Chinese medicine of treatment vitiligo of the present invention is prepared from by following component, all in weight portion:
12 parts of Fructus Psoraleaes, 6 parts of the Radixs Astragali, 6 parts of Radix Angelicae Sinensis, 10 parts of Radix Salviae Miltiorrhizaes, 10 parts on Flos Carthami, 10 parts of Rhizoma Chuanxiongs, 5 parts of Semen Persicae (parched)s, 7 parts of Rhizoma Cyperis, 7 parts of Radix Arnebiae (Radix Lithospermi)s, 20 parts of Fructus Tribulis, 7 parts of Cortex Dictamni, 5 parts of Radix Gentianae.
Other component batching processing and preparation method are with embodiment 1.
Claims (6)
1. Chinese medicine for the treatment of vitiligo, it is characterized in that, be prepared from by following component, all in weight portion: 11.2～20.8 parts of Fructus Psoraleaes, 5.6～10.4 parts of the Radixs Astragali, 5.6～10.4 parts of Radix Angelicae Sinensis, 5.6～10.4 parts of Radix Salviae Miltiorrhizaes, 5.6～10.4 parts on Flos Carthami, 5.6～10.4 parts of Rhizoma Chuanxiongs, 2.8～5.2 parts of Semen Persicae (parched)s, 4.2～7.8 parts of Rhizoma Cyperis, 4.2～7.8 parts of Radix Arnebiae (Radix Lithospermi)s, 12.6～23.4 parts of Fructus Tribulis, 4.2～7.8 parts of Cortex Dictamni, 2.8～5.2 parts of Radix Gentianae.
2. the Chinese medicine of treatment vitiligo as claimed in claim 1, it is characterized in that, be prepared from by following component, all in weight portion: 12 parts of Fructus Psoraleaes, 6 parts of the Radixs Astragali, 6 parts of Radix Angelicae Sinensis, 6 parts of Radix Salviae Miltiorrhizaes, 6 parts on Flos Carthami, 10 parts of Rhizoma Chuanxiongs, 5 parts of Semen Persicae (parched)s, 7 parts of Rhizoma Cyperis, 7 parts of Radix Arnebiae (Radix Lithospermi)s, 22 parts of Fructus Tribulis, 6 parts of Cortex Dictamni, 4 parts of Radix Gentianae.
3. the Chinese medicine of treatment vitiligo as claimed in claim 1, it is characterized in that, be prepared from by following component, all in weight portion: 12 parts of Fructus Psoraleaes, 6 parts of the Radixs Astragali, 6 parts of Radix Angelicae Sinensis, 6 parts of Radix Salviae Miltiorrhizaes, 6 parts on Flos Carthami, 10 parts of Rhizoma Chuanxiongs, 5 parts of Semen Persicae (parched)s, 7 parts of Rhizoma Cyperis, 7 parts of Radix Arnebiae (Radix Lithospermi)s, 21 parts of Fructus Tribulis, 7 parts of Cortex Dictamni, 5 parts of Radix Gentianae.
4. the Chinese medicine of treatment vitiligo as claimed in claim 1, it is characterized in that, be prepared from by following component, all in weight portion: 12 parts of Fructus Psoraleaes, 6 parts of the Radixs Astragali, 6 parts of Radix Angelicae Sinensis, 10 parts of Radix Salviae Miltiorrhizaes, 10 parts on Flos Carthami, 10 parts of Rhizoma Chuanxiongs, 5 parts of Semen Persicae (parched)s, 7 parts of Rhizoma Cyperis, 7 parts of Radix Arnebiae (Radix Lithospermi)s, 20 parts of Fructus Tribulis, 7 parts of Cortex Dictamni, 5 parts of Radix Gentianae.
5. the Chinese medicine of treatment vitiligo as claimed in claim 1 is characterized in that: dosage form is capsule, tablet or granule.
6. treat the vitiligo preparation method of Chinese medicine according to claim 1, it is characterized in that concrete steps are as follows:
(1) get 20～60% dry sterilizations of Radix Salviae Miltiorrhizae total amount by ingredients weight parts, be ground into fine powder, sieve, standby;
(2) get remaining Radix Salviae Miltiorrhizae and by ingredients weight parts get Fructus Psoraleae etc. all the other ten simply Chinese medicine decoct with water and extract three times, the decocting that adds for the first time 4～7 times of amounts of whole extraction medical material weight boiled 2 hours, adding for the second time 3～6 times of water gagings of whole extraction medical material weight decocted 1.5 hours, adding 2～4 times of water gagings of whole extraction medical material weight for the third time decocted 1.0 hours, collecting decoction filters or/and leave standstill;
(3) get filtrate or/and supernatant is condensed into thick paste, drying is ground into fine powder, sieves;
(4) add above-mentioned Radix Salviae Miltiorrhizae fine powder mixing, add or do not add pharmaceutic adjuvant, granulate or do not granulate, be packed into capsule and promptly get capsule; Or an amount of compacting of granulating or do not granulate of interpolation pharmaceutic adjuvant promptly gets tablet in flakes; Or add pharmaceutic adjuvant and make granule in right amount and promptly get granule.
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| Application Number | Priority Date | Filing Date | Title |
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| CN2008101384978A CN101322788B (en) | 2008-08-07 | 2008-08-07 | Chinese medicine for treating vitiligo and preparation |
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| Application Number | Priority Date | Filing Date | Title |
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| CN2008101384978A CN101322788B (en) | 2008-08-07 | 2008-08-07 | Chinese medicine for treating vitiligo and preparation |
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| CN101322788A CN101322788A (en) | 2008-12-17 |
| CN101322788B true CN101322788B (en) | 2011-06-29 |
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| CN103830659A (en) * | 2012-11-28 | 2014-06-04 | 江苏丹晟生物科技有限公司 | Traditional Chinese medicine for treating leucoderma |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1368235A (en) * | 2001-02-01 | 2002-09-11 | 杨孟君 | Nano medicine for treating leukoderma and its preparing process |
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1368235A (en) * | 2001-02-01 | 2002-09-11 | 杨孟君 | Nano medicine for treating leukoderma and its preparing process |
Non-Patent Citations (1)
| Title |
|---|
| 屈岚,等.中医药治疗白癜风研究探要.《中医药学刊》.2004,第22卷(第3期),529-531. * |
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