CN102370886A - Traditional Chinese medicinal composition for resisting breast cancer metastasis - Google Patents
Traditional Chinese medicinal composition for resisting breast cancer metastasis Download PDFInfo
- Publication number
- CN102370886A CN102370886A CN2010102578446A CN201010257844A CN102370886A CN 102370886 A CN102370886 A CN 102370886A CN 2010102578446 A CN2010102578446 A CN 2010102578446A CN 201010257844 A CN201010257844 A CN 201010257844A CN 102370886 A CN102370886 A CN 102370886A
- Authority
- CN
- China
- Prior art keywords
- parts
- chinese medicine
- radix
- breast cancer
- hour
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Abstract
The invention provides a traditional Chinese medicinal composition for resisting breast cancer metastasis. The traditional Chinese medicinal composition is prepared by the following Chinese medicinal materials by weight: 10-60 parts of white ginseng, 5-30 parts of morinda officinalis, 10-50 parts of lychee seeds, 10-50 parts of rhizoma polygonati, 10-40 parts of manyprickle acanthopanax, and 10-50 parts of fructus liquidambaris. The traditional Chinese medicinal composition provided in the invention can resist breast cancer metastasis.
Description
Technical field
The present invention relates to the Chinese medicine composition that a kind of anti-breast cancer shifts, belong to the field of Chinese medicines.
Technical background
Malignant tumor is commonly encountered diseases, the frequently-occurring disease of one type of serious harm people ' s health and life.Wherein breast carcinoma is one of human comparatively common tumor; Its sickness rate is high; For the female tumor morbidity is first, this illness is one of main illness of serious harm young women health and lives at present, and the number of national annual New Development breast carcinoma is about more than 1,000,000.
Breast cancer cell shifts the same with other neoplasm metastasis, is the process of a complicacy, and tumor cell is through breaking away from primary lesion; Pass basement membrane and substrate and get into blood circulation; Carry out selective attachment with vascular endothelial cell then, pass basement membrane of blood vessel again and destroy extracellular matrix, and then get into the dystopy organ; Proceed cell growth, division and new vessels and generate or the like, form metastatic lesion.The target spot that has a lot of treatments in the whole transfer process, but the complete mechanism of anti metastasis is also not exclusively clear, also needs further to inquire into and research.And the antineoplaston of Chinese medicine just is conceived to integral body, is comprehensive human body immunity improving power, improves high blood coagulation state and microcirculation disturbance, reduces thrombosis and chance occurs, alleviates tissue edema etc.Many researchs have proved that also Chinese medicine and effective ingredient thereof have good antitumor, the effect of anti metastasis, are one of important auxiliary treatment of traditional antitumor, anti metastasis treatment.
The present invention is directed to blood stasis due to qi deficiency state behind the common postoperative of patient with breast cancer, the chemicotherapy; With " QI invigorating blood stasis dispelling " is rule of treatment principle; Having selected Chinese crude drug Radix Ginseng, Radix Morindae Officinalis, Semen Litchi, Rhizoma Polygonati, Radix Et Caulis Acanthopanacis Senticosi, Fructus Liquidambaris is the raw material prescription, is prepared into to play the Chinese medicine preparation that anti-breast cancer shifts.
Chinese invention patent publication number CN1249946 discloses a kind of Chinese medicine composition of treating breast carcinoma and preparation method thereof, is raw material by Herba Ipomoeae Cairicae; Chinese invention patent publication number CN1410097 discloses a kind of Chinese patent medicine of treating breast carcinoma, is processed by nine flavor Chinese herbal medicine such as Fructus Trichosanthis, big gun Squama Manis, Herba Taraxaci, Colla Cornus Cervi, Rhizoma Paridis, Pseudobulbus Cremastrae seu Pleiones, Borax, Huechys sanguinea De Geer., sea clam powder.Chinese invention patent publication number CN1872284 discloses a kind of Chinese medicine of treating breast carcinoma, is made up of Semen Coicis, Ganoderma, Semen Vaccariae, Rhizoma Cyperi, Pseudobulbus Cremastrae Seu Pleiones and Gekko Swinhonis; These inventions are treatment breast carcinoma, play blood circulation promoting and blood stasis dispelling, and eliminating stagnation dispersing tumor effect has obvious curative effects to breast carcinoma.But the transferance to anti-breast cancer is not mentioned.
Summary of the invention:
The Chinese medicine composition that the object of the invention provides a kind of anti-breast cancer to shift is guidance with the Chinese medicine basic theories, through the rational proportion of each Chinese crude drug, plays the effect that suppresses Metastasis in Breast Cancer.
The Chinese medicine preparation that anti-breast cancer of the present invention shifts selects Radix Ginseng, Radix Morindae Officinalis, Semen Litchi, Rhizoma Polygonati, Radix Et Caulis Acanthopanacis Senticosi, Fructus Liquidambaris to carry out the combined preparation active component.Wherein Radix Ginseng, Radix Morindae Officinalis, Rhizoma Polygonati have QI invigorating tonifying YIN effect, and Semen Litchi, Radix Et Caulis Acanthopanacis Senticosi, Fructus Liquidambaris have acupuncture-stimulating blood stasis dispersing, detoxicating and resolving stagnation of pathogens effect.The shared function that plays the QI invigorating blood stasis dispelling of above-mentioned five kinds of Chinese medicine plays the effect that anti-breast cancer shifts.
Characteristics of the present invention are: this invention Chinese medicine composition is to the empty stasis of blood state behind the women with breast cancer chemoradiotherapy, is that the rule of treatment selects the medicine prescription to suppress Metastasis in Breast Cancer with the QI invigorating blood stasis dispelling.
The raw material consumption of preparation medicine activity component of the present invention is: Radix Ginseng 10-60 part, Radix Morindae Officinalis 5-30 part, Semen Litchi 10-50 part, Rhizoma Polygonati 10-50 part, Radix Et Caulis Acanthopanacis Senticosi 10-40 part, Fructus Liquidambaris 10-50 part; Be preferably 45 parts of Radix Ginseng, 9 parts of Radix Morindae Officinaliss, 12 parts of Semen Litchis, 18 parts of Rhizoma Polygonatis, 12 parts of Radix Et Caulis Acanthopanacis Senticosis, 9 parts of Fructus Liquidambaris.
Chinese medicine composition of the present invention is made by following method:
Radix Ginseng, Radix Morindae Officinalis, Semen Litchi, Rhizoma Polygonati, Radix Et Caulis Acanthopanacis Senticosi and Fructus Liquidambaris are mixed according to above-mentioned weight ratio, add 6-10 times of water gaging and soaked 1-2 hour, preferred 8 times of water gagings soaked 1.5 hours, and decocting extracted 0.5-3 hour, and preferred 1.5 hours, filter, collect filtrating; Filtering residue adds 5-8 times of water gaging, preferred 6 times of water gagings, and decocting extracted 0.5-2 hour, and preferred 1 hour, filter, collect filtrating, merging filtrate; Filtrating evaporation is flung to liquid and is prepared into dry extract, and 80 ℃ are ground into fine powder after being baked to bone dry in baking oven.
Above-mentioned fine powder can add the various conventional adjuvant for preparing different dosage form, is prepared into the common Chinese medicine preparation formulation by the method for Chinese medicinal of routine, like tablet, capsule, oral liquid, electuary etc.
Below in conjunction with embodiment the present invention is done further elaboration, but be not limited to this.
Embodiment 1 preparation tablets of the present invention (is example with ten times of material proportional quantities)
1. take by weighing each crude drug by following weight proportion
450 parts of Radix Ginseng, 90 parts of Radix Morindae Officinaliss, 120 parts of Semen Litchis, 180 parts of Rhizoma Polygonatis, 120 parts of Radix Et Caulis Acanthopanacis Senticosis, 90 parts of Fructus Liquidambaris are subsequent use.
2. above-mentioned weight ratio is mixed, and adds 8 times of water gagings and soaks 1.5 hours, and decocting extracted 1.5 hours, filtered, and collected filtrating; Filtering residue adds 6 times of water gagings, and decocting extracted 1 hour, filters, and collects filtrating, merging filtrate; Filtrating evaporation is flung to liquid and is prepared into dry extract, and 80 ℃ are ground into fine powder after being baked to bone dry in baking oven.
3. above-mentioned fine powder adds adjuvant and processes granule, drying, and tabletting promptly gets.
The influence that experimental example 1 Chinese medicine composition of the present invention shifts mouse breast cancer tumour
Mouse breast cancer modelling: get well-grown 4T1 breast carcinoma solid tumor that goes down to posterity, prepare tumor cell suspension, transfer cell number 5 * 10 with normal saline
6Individual cell/ml only is inoculated under 40 BALB/c mouse mammary fat pad by 0.1ml/, and mice is divided into 4 groups at random, and 10 every group, by following method treatment.
Chinese medicine composition dose groups of the present invention comprises high dose group (20g/kg), middle dose groups (10g/kg), low dose group (5g/kg); Every day gastric infusion once, continuous 14 days; Matched group gives the equivalent normal saline, puts to death mice next day in drug withdrawal, weighs, and peels off lungs and shifts tuberosity, calculates breast carcinoma lung metastasis inhibition rate, and the result sees the following form.
Claims (4)
1.-plant the Chinese medicine composition that anti-breast cancer shifts, it is characterized in that: the raw material of Chinese medicine by following weight parts is formed: Radix Ginseng 10-60 part, Radix Morindae Officinalis 5-30 part, Semen Litchi 10-50 part, Rhizoma Polygonati 10-50 part, Radix Et Caulis Acanthopanacis Senticosi 10-40 part, Fructus Liquidambaris 10-50 part are formed.
2. the Chinese medicine composition that shifts according to the said anti-breast cancer of claim 1, it is characterized in that: the raw material of Chinese medicine by following weight parts is formed: 45 parts of Radix Ginseng, 9 parts of Radix Morindae Officinaliss, 12 parts of Semen Litchis, 18 parts of Rhizoma Polygonatis, 12 parts of Radix Et Caulis Acanthopanacis Senticosis, Fructus Liquidambaris are formed for 9 parts.
3. according to claim 1, the method for preparing of 2 described Chinese medicine compositions comprises the steps:
(1) Radix Ginseng, Radix Morindae Officinalis, Semen Litchi, Rhizoma Polygonati, Radix Et Caulis Acanthopanacis Senticosi and Fructus Liquidambaris are mixed according to above-mentioned weight ratio, add 6-10 times of water gaging and soaked 1-2 hour, preferred 8 times of water gagings soaked 1.5 hours; Decocting extracted 0.5-3 hour; Preferred 1.5 hours, filter, collect filtrating; Filtering residue adds 5-8 times of water gaging, preferred 6 times of water gagings, and decocting extracted 0.5-2 hour, and preferred 1 hour, filter, collect filtrating; Merging filtrate.
(2) filtrating evaporation is flung to liquid and is prepared thousands of extractum, and 80 ℃ are ground into fine powder after being baked to bone dry in baking oven.
(3) above-mentioned fine powder can add the various conventional adjuvant of preparation needs during different dosage form, is prepared into the common Chinese medicine preparation formulation by the method for Chinese medicinal of routine, like tablet, capsule, oral liquid, electuary etc.
4. claim 1,2 described Chinese medicine compositions, it has the purposes of anti-breast cancer transferance.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201010257844 CN102370886B (en) | 2010-08-18 | 2010-08-18 | Traditional Chinese medicinal composition for resisting breast cancer metastasis |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201010257844 CN102370886B (en) | 2010-08-18 | 2010-08-18 | Traditional Chinese medicinal composition for resisting breast cancer metastasis |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102370886A true CN102370886A (en) | 2012-03-14 |
| CN102370886B CN102370886B (en) | 2013-07-31 |
Family
ID=45790470
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 201010257844 Expired - Fee Related CN102370886B (en) | 2010-08-18 | 2010-08-18 | Traditional Chinese medicinal composition for resisting breast cancer metastasis |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102370886B (en) |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101670071A (en) * | 2009-09-25 | 2010-03-17 | 卢速江 | Traditional Chinese medicine preparation for treating cancer and preparation method thereof |
-
2010
- 2010-08-18 CN CN 201010257844 patent/CN102370886B/en not_active Expired - Fee Related
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101670071A (en) * | 2009-09-25 | 2010-03-17 | 卢速江 | Traditional Chinese medicine preparation for treating cancer and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 谭开基，曹洋，黎壮伟: "陈锐深辨治晚期乳腺癌的方法与思路", 《上海中医药杂志》, vol. 39, no. 7, 31 July 2005 (2005-07-31), pages 17 - 18 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN102370886B (en) | 2013-07-31 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN104984316A (en) | Medicine for treating female cold in uterus | |
| CN101518594B (en) | Anti-tumor immunity-enhancing traditional Chinese medicine preparation and preparation method thereof | |
| CN101530508B (en) | Traditional Chinese medicine for treating ovarian cancer | |
| CN101564464B (en) | Chinese medicament for adjusting organism immunity of tumor patients | |
| CN101518607B (en) | Traditional Chinese medicine for treating carcinoma of kidney | |
| CN102370886B (en) | Traditional Chinese medicinal composition for resisting breast cancer metastasis | |
| CN102416121A (en) | Application of medicinal composition to preparation of medicaments for treating gastric ulcer | |
| CN100584317C (en) | Traditional Chinese medicine compound preparation for preventing gastric cancer metastasis and preparation method thereof | |
| CN105126034A (en) | Pharmaceutical preparation for treating coronary heart disease | |
| CN104840773A (en) | Traditional Chinese medicine composition for treating vertebral artery type cervical spondylopathy and method for preparing same | |
| CN101554443B (en) | Traditional Chinese medicine for treating angina | |
| CN100493571C (en) | Medicine for treating heart failure | |
| CN101088555B (en) | Medicine preparation for inhibiting tumor angiogenesis and cancer cell and enhancing immunity | |
| CN101130009A (en) | Proprietary Chinese medicine for treating atherosclerosis of cardio-cerebral arteria and method for preparing the same | |
| CN105412755A (en) | Preparation method of medicament capsules with function of relieving radiotherapy reactions of tumor patients | |
| CN102614373A (en) | Patch for treating aortic arch syndrome | |
| CN102125680A (en) | Anticancer traditional Chinese medicinal composition and use thereof | |
| CN101537068B (en) | Chinese medicine for treating angina | |
| CN101322788B (en) | Chinese medicine for treating vitiligo and preparation | |
| CN102274358B (en) | Traditional Chinese medicine for treating premature menstruation, profuse menstruation, breast distending pain and large clot quantity | |
| CN1253003A (en) | Compound graceful jassamine preparation | |
| CN105664048A (en) | Pharmaceutical composition inhibiting gastric cancer cell proliferation and application thereof | |
| CN102512546B (en) | Traditional Chinese medicine used for esophageal cancer patients refusing surgery | |
| CN104606537A (en) | Qi-reinforcing and blood-nourishing medicated diet for improving chemotherapy-induced myocardial ischemic injury and preparation method | |
| CN101843678B (en) | Chinese medicament for treating climacteric syndromes |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20130731 Termination date: 20140818 |
|
| EXPY | Termination of patent right or utility model |