CN101391074B - Medicine composition for treating digestive system carcinoma and preparation method thereof - Google Patents
Medicine composition for treating digestive system carcinoma and preparation method thereof Download PDFInfo
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Abstract
The invention relates to a medicine compound for treating digestive system carcinoma and with traditional Chinese herbs as the raw material, which is composed of the following materials: gecko house lizard, paris, cardamom, rhizome pinelliae preparata, liquorice roots, rhizoma coptidis, artificial cow-bezoar, centipede, scorpio, platycodon roots, white peony roots, dried tangerine peels, musk and the like. The medicine compound not only has the function of clearing away heat and toxic materials, dissipating phlegm for resuscitation and resolving masses for relieving pain, but also can supplement part of minor elements for the human body, improve the body immunity, and inhibit the growth of cancer cells. The invention has an instant effect to the diseases such as esophageal stenosis obstruction, dysphagia, the disease with no way to drink water, abdominal distension and the like caused by digestive system middle-advanced cancers.
Description
Technical field
The present invention relates to a kind of pharmaceutical composition, particularly relating to a kind of is the pharmaceutical composition of raw material treatment digestive system carcinoma with the Chinese herbal medicine.
Technical background
Digestive tract tumor's sickness rate height, state of an illness complexity, it mainly is that the whole world has 800,000 people to die from digestive system carcinoma approximately at present owing to eat the food that contains nitrite, go mouldy food and the stronger former thereby morbidities such as food of zest for a long time.China is the district occurred frequently of digestive system carcinoma, and according to the preliminary statistics, it all is Chinese that nearly 1/2 digestive system carcinoma is arranged in the world, and is annual because of about 400,000 people of digestive system carcinoma death toll, accounts for half of the dead sum of whole malignant tumor.Suffer from digestive system carcinoma and mainly show progressive emaciation, dysphagia, nausea and vomiting, stomachache, is detested clinical manifestations such as greasy at jaundice.The early stage state of an illness is lighter, easily out in the cold, and weight person easily causes transfer, and severe patient can lose the therapy apparatus meeting.The method of treatment digestive system carcinoma has operation, chemotherapy, radiotherapy, Chinese medicine etc. at present, and it is first-selected that operative treatment mostly is, but strict indication is arranged, influenced by various factors, radical rate is lower, the expense height, and the danger in the art, post-operative complication etc. are thorny problem.Chemotherapy and radiation all has serious toxic and side effects, and patient is beyond affordability; And Chinese medical and herbal therapy can effectively solve problems such as traumatic, dangerous, the toxicity of operation, promptly be the centering end-stage patients, older, having a delicate constitution, merge multiple transferrer all can dialectical medication, and expense is cheap, is easily accepted by vast poor patient.Though the Chinese patent medicine of multiple treatment esophageal carcinoma is arranged on the market at present, efficacy result is not remarkable, the course of treatment is long.Announcing a kind of patent No. on State Intellectual Property Office's patent gazette on November 10th, 2004 is " a kind of pharmaceutical composition for the treatment of esophageal carcinoma " patent of 02125611.x, it is to be made by crude drug such as semen juglandis, stir-baked SEMEN ARMENIACAE AMARUM, Rabdosia rubescens, Rhizoma Coptidis, Radix Sophorae Tonkinensis, Radix Scrophulariae, Bulbus Fritillariae Cirrhosae, Radix Platycodonis, KOUREN, the Radix Aucklandiae, Fructus Amomi, Chinese scholartree meat, Radix Glycyrrhizae, though treatment esophageal carcinoma, chronic pharyngitis are had certain curative effect, and the course of treatment is long, effective percentage is low.
Summary of the invention
In order to overcome the deficiencies in the prior art, the invention provides a kind of is raw material with the Chinese herbal medicine, the pharmaceutical composition of the treatment digestive system carcinoma that toxic and side effects is little, evident in efficacy.
The invention still further relates to the method for this pharmaceutical composition of preparation.
The object of the present invention is achieved like this: a kind of pharmaceutical composition for the treatment of digestive system carcinoma is achieved by the following technical solution:
Choose crude drug:
Gekko Swinhonis 40～60 weight portions; Rhizoma Paridis 40～60 weight portions; Radix Notoginseng 30～50 weight portions; Bulbus Fritillariae Cirrhosae 30～50 weight portions; Fructus Amomi 30～50 weight portions; Fructus Amomi Rotundus 30～50 weight portions; Rhizoma Pinelliae Preparata 22～30 weight portions; Radix Glycyrrhizae 20～40 weight portions; Radix Rehmanniae Preparata 20～28 weight portions; Rhizoma Coptidis 10～30 weight portions; artificial Calculus Bovis's 10～30 weight portions; Fructus Mume 10～30 weight portions; Radix Sophorae Tonkinensis 5～15 weight portions; Scolopendra 5～15 weight portions; Scorpio 5～25 weight portions; Fructus Gardeniae 5～25 weight portions; Radix Ophiopogonis 5～25 weight portion; Radix Platycodonis 5～25 weight portions; Radix Angelicae Sinensis 5～25 weight portions; the Radix Paeoniae Alba 5～25 weight portions; Pericarpium Citri Reticulatae 5～25 weight portions; Moschus 0～2 weight portion.
Pharmaceutical composition preferred weight proportioning of the present invention is to choose crude drug:
Gekko Swinhonis 45～55 weight portions; Rhizoma Paridis 45～55 weight portions; Radix Notoginseng 35～45 weight portions; Bulbus Fritillariae Cirrhosae 35～45 weight portions; Fructus Amomi 35～45 weight portions; Fructus Amomi Rotundus 35～45 weight portions; Radix Glycyrrhizae 25～35 weight portions; Rhizoma Pinelliae Preparata 24～28 weight portions; Radix Rehmanniae Preparata 22～26 weight portions; Fructus Mume 15～25 weight portions; Rhizoma Coptidis 15～25 weight portions; artificial Calculus Bovis's 15～25 weight portions; Fructus Gardeniae 10～20 weight portions; Radix Ophiopogonis 10～20 weight portion; Radix Platycodonis 10～20 weight portions; Radix Angelicae Sinensis 10～20 weight portions; the Radix Paeoniae Alba 10～20 weight portions; Scorpio 10～20 weight portions; Scorpio 10～20 weight portions; Pericarpium Citri Reticulatae 10～20 weight portions; Scolopendra 5～15 weight portions; Radix Sophorae Tonkinensis 8～12 weight portions; Moschus 0～2 weight portion.
Pharmaceutical composition optimum weight proportioning of the present invention, choose crude drug and be:
Gekko Swinhonis 50 weight portions; Rhizoma Paridis 50 weight portions; Radix Notoginseng 40 weight portions; Bulbus Fritillariae Cirrhosae 40 weight portions; Fructus Amomi 40 weight portions; Fructus Amomi Rotundus 40 weight portions; Radix Glycyrrhizae 30 weight portions; Rhizoma Pinelliae Preparata 26 weight portions; Radix Rehmanniae Preparata 24 weight portions; artificial Calculus Bovis's 20 weight portions; Rhizoma Coptidis 20 weight portions; Fructus Mume 20 weight portions; Scorpio 15 weight portions; Fructus Gardeniae 15 weight portions; Radix Ophiopogonis 15 weight portion; Radix Platycodonis 15 weight portions; Radix Angelicae Sinensis 15 weight portions; the Radix Paeoniae Alba 15 weight portions; Pericarpium Citri Reticulatae 15 weight portions; Scolopendra 10 weight portions; Radix Sophorae Tonkinensis 10 weight portions; Moschus 1 weight portion.
Preparation of drug combination method of the present invention is: above-mentioned each crude drug is weighed respectively, roguing, is ground into fine powder and crosses 80 mesh sieves according to weight portion, and mixing is standby; Add brown sugar, the little fire heating of each 250 gram of white sugar with 500 gram weight part Mel and boil the fusing back half an hour and add above-mentioned raw material medicated powder, make the honeyed pill of every ball 9 grams, press mold, dress box.Artificial Calculus Bovis in the crude drug wherein of the present invention is the main component according to natural Calculus Bovis: a kind of Calculus Bovis succedaneum of artificial preparation such as bilirubin, cholic acid, cholesterol, inorganic salt, and from the finished product of pharmaceuticals's purchase.And Rhizoma Pinelliae Preparata is a Rhizoma Pinelliae with behind the Rhizoma Zingiberis Recens decocting in water, and section is dried and formed.Usage: 3 balls/time, 3 times on the one, ante cibum is oral.1 month is 1 course of treatment.
The present invention is based on secret prescription handed down in the family from generation to generation and traditional Chinese medical science traditional medical theory, through clinical trial preparation repeatedly.The reason that various tumors form due to qi depression to blood stasis, retardance meridians, is pented up with phlegm-damp, heat-transformation becomes poison, pyretic toxicity to condense, and with the passing of time condenses the cancer that forms.Artificial Calculus Bovis, Rhizoma Paridis (Rhizoma Paridis) have heat-clearing and toxic substances removing, sharp expectorant have one's ideas straightened out, subside a swelling removing food stagnancy piece, the pain that relieves the pain, and Gekko Swinhonis looses and separates pain relieving, and this three flavors medicine crude drug is as being mainly monarch.Accessory drugs is had one's ideas straightened out with Radix Notoginseng, Moschus (MOSCHUS) and is warded off dirty, blood circulation promoting and blood stasis dispelling, pain relieving, hemostasis, the clear tumor of eliminating stagnation; Full scorpion obstruction removing relieves dizziness, high fever, infantile convulsions, epilepsy, etc., spasmolysis and analgesia; Rhizoma Coptidis, Fructus Gardeniae, Radix Sophorae Tonkinensis, Radix Ophiopogonis, Radix Platycodonis, Fructus Mume relieving sore-throat by clearing away heat, the eliminating stagnation YIN nourishing; The Radix Paeoniae Alba, Radix Rehmanniae Preparata, Chinese angelica blood supplementing nourish blood; Assistant reaches regulating the stomach to normalize QI, dissipating phlegm and resolving masses jointly with the Rhizoma Pinelliae, Bulbus Fritillariae Cirrhosae, Pericarpium Citri Reticulatae, Fructus Amomi; The Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription is for making.
Pharmaceutical composition for the treatment of digestive tract tumor of the present invention is compared with prior art, have the property of medicine steadily, anti-inflammation detumescence, analgesia and improve the circulation effect, and can replenish the human body parts trace element, human body immunity improving power, kill cancer cell and anticancer growth, and prevent the cancerous cell diffusion.This medicine centering, the esophageal stricture that late period, digestive system carcinoma caused block, dysphagia, do not take even a drop of water, abdominal distention etc. has the effect of getting instant result.
The specific embodiment
Below in conjunction with embodiment the present invention is further detailed.
Model case
Case 1:
Xu * *, woman, 42.
Did esophagoscope and pathological diagnosis to hospital: the esophagus scale cancer because of carrying out property dysphagia in 2003.Gastrointestinal image shows: esophago mesomere cancer is long 5 centimetres, and invades the flesh layer, and with the aorta adhesion, hilus pulumonis and mediastinal lymph nodes are all seen transfer, can't excise and closes breast.Treatment: patient is 2 weeks after exploratory thoracotomy, implement cobalt 60 radiotherapies.Patient is continuous to be occurred for 5 times dizzyly, weakly feel sick, vomit, perspire abnormal sweat, pale complexion, the vexed pain of anterior part of chest unbearably, leukopenia to 3000/ cubic millimeter can not be adhered to radiotherapy, can only the influent stream food.Introduce through friend that to take the present invention's " containing of dispersing tumor ball " surplus February, patient feels that suffocating pain over the chest improves, dysphagia is also obviously improved, taking medicine, patient can enter small amount of solid food after January, patient is interrupted over 3 years and takes the present invention's " containing of dispersing tumor ball " survival to 8 years 06 months, this advanced esophageal cancer shifts patient, be judged to maximum survivals 3 months by hospital and through take " containing of dispersing tumor ball " patient survival 8 years surplus, still be still living and in good health.
Case 2
Poplar * *, man, 61.
In JIUYUE, 2003, patient's self-induction is swallowed and is choked with sobs, the esophagus discomfort, and foreign body sensation is arranged, and surplus March with shirtfront, back part pain, satisfies to the People's Hospital, Henan city and checks, is diagnosed as " breaking up squamous cell carcinoma in the esophagus in the hypomere ", has done " hypomere excision in the esophagus ".In July, 2004, the patient checks to hospital because of stomachache, abdominal distention, malaise, finds that stomach has metastatic lesion, always at hospitalization.During this time, conditions of patients was once spent deterioration, upper and lower extremities edema, progressive emaciation, can't take food, and hospital has also abandoned the treatment to him.Just at this moment, after the patient took the present invention's " containing of dispersing tumor ball " two courses of treatment upon somebody's introduction, the upper limb edema obviously went down, and can take food, and spirit has change than before greatly.
Case 3
Open * *, woman, 60.
The patient touches the big lump of fist because of stomach discomfort, pain, abdominal distention and gastral cavilty portion in October, 2002, and matter is hard, and through the big First Academy of Harbin medical courses in general B ultrasonic, CT examination, swollen thing is 6X13cm, is diagnosed as gastric cancer.On November 23rd, 1999 was done resection of gastric carcinoma in Harbin railway hospital.Pathological diagnosis is to break up in the adenocarcinoma of stomach, and does twice radiotherapy of chemotherapy 3 times.The recurrence of the residual gastropathy kitchen range of ultrasound diagnosis in July, 2003, size is 6.1X4.7cm, and has a stomach-ache, flatulence, feels sick, becomes thin, and is weak all over the body, so can not perform the operation once more.Introduce come my institute treatment through the people in July, 2003, belongs to resistance type in the stasis of blood poison according to clinical manifestation.Take the present invention's " containing of dispersing tumor ball " after three months, subjective symptoms be clearly better, weight increase, antisecosis.Check on February 6th, 2004, focus is obviously dwindled, and size is 4.8X4.6cm.Ultrasound diagnosis on August 26 in 2004, the complete obiteration of residual stomach recurrence kitchen range, weight increase 8kg is interrupted and takes the present invention's " containing of dispersing tumor ball " half a year, weight increase 10.5kg, antisecosis, diet is normal, normally working, health returns to be suffered from before the carninomatosis.
One, clinical experiment:
In order to observe the clinical efficacy that the present invention's " containing of dispersing tumor ball " adds the combination chemotherapy esophageal carcinoma, we are divided into two groups at random to 65 routine esophageal carcinoma patients, and the treatment group adopts containing of dispersing tumor ball to add combined chemotherapy, matched group list combined chemotherapy, carry out the clinicaling curative effect contrast observation, now be reported as follows:
Treatment group 30 example adopts containing of dispersing tumor balls to add PF or POD scheme, and the matched group list is with PF or POD scheme (seeing Table).
Containing of table one dispersing tumor ball combined with chemotherapy esophageal carcinoma case situation
| Scheme | The example number | The man | The woman | Age | 1 phase | 2 phases | 3 phases |
| Containing of dispersing tumor ball PF/POD | 30 | 24 | 6 | 35-72 | 1 | 4 | 25 |
| PF/POD | 35 | 27 | 8 | 28-75 | 1 | 3 | 31 |
All cases all confirm through cytology or pathology, are squamous cell carcinoma, and treatment front and back digestive tract barium meal X machine photo is all arranged.
The PF scheme: DDP30mg iv dashed the 1st～5 day, 5～FU500～750mg ivdrip the 1st～5 day, and per three weeks repeat once, and 6 weeks were a course of treatment.
The POD scheme: DDP50mg iv dashed the 1st～3 day, and VCR2mg iv dashes weekly, and pym20mg iv dashes weekly, and per three weeks repeat once, and 6 weeks were a course of treatment.Containing of dispersing tumor ball: each 0.5～1g, every day three times, total amount 60～90g.
The therapeutic evaluation standard is pressed the objective efficacy assessment standard of solid tumor of " cancer therapy drug clinical guidance principle " defined: promptly alleviate (CD), partly alleviation (RR), improvement (MR) fully, stablize (SD), progress (PD), therapeutic effect (seeing Table two).
Containing of table two dispersing tumor ball cooperates the curative effect of combined chemotherapy
| Grouping | The example number | PR | MR | SD | PD | CR+PR | |
| The treatment group | 30 | 3 | 9 | 8 | 4 | 6 | 12(40％) |
| Matched group | 35 | 1 | 9 | 6 | 8 | 9 | 10(30％) |
Toxic reaction: part patient (about 1/3) takes behind containing of the dispersing tumor ball slightly inappetence, and slight digestive tract reaction such as feel sick mostly is momentary, can not drug withdrawal, and containing of dispersing tumor ball does not have bone marrow depression and nervous system toxic reaction, does not influence heart and hepatic and renal function.
From end of the year November to 1998 nineteen ninety-five, we show by containing of dispersing tumor ball being carried out a large amount of clinical observation on the therapeutic effect: all the general situation of patient shows change, improve patient's sleep, appetite rapidly, improve life quality and KPS value, (T3, T4 increase T8 and reduce raise immunity, it is normal that T4, T8 value recover) dwindle tumor body portion remission rate and reach 88.58%, to early, the esophagus discomfort that causes of middle and advanced stage digestive tract tumor, swallow because of only, take food block, do not take even a drop of water, pain etc. can play the effect of getting instant result.Have (1) containing of pill: through focus, medicine directly acts on cancerous issue, and removing the necrotic tissue and promoting granulation can suppress and kill cancerous cell fast.(2) mediation esophagus, get instant result: containing of dispersing tumor ball has significant spasmolysis to the esophagus smooth muscle, improve the esophagus local circulation fast, just can take food in 10～30 minutes after taking medicine, alleviate rapidly malignant tumor patient esophagus discomfort, dysphagias such as middle and advanced stage esophageal carcinoma, carcinoma of gastric cardia, gastric cancer, hepatocarcinoma, carcinoma of gallbladder, pancreas, do not take even a drop of water, phenomenon such as pain, 500 routine patient's medication overall processes are not found serious toxic and side effects.
Conclusion: containing of dispersing tumor ball is in the medicine of present clinical complex treatment malignant tumor, and safe, reliable and effective anticancer compound Chinese patent medicine is worth further promoting the use of.
Two, toxicity research:
1, acute toxicity testing: choosing 20 of healthy rats, is 9.38g/KQ (consumption per day of quite being grown up 626 times) through the 6.11g/Kg of intraperitoneal administration the present invention " containing of dispersing tumor ball ", through gastric infusion " containing of dispersing tumor ball ".
Test shows: malicious epiphenomenon does not appear in rat, and is in good condition.
2, long term toxicity test: 20 healthy rats are pressed 0.5Q/Kg, 1g/Kg, 2Q/Kg grouping, gastric infusion every day " containing of dispersing tumor ball " once, successive administration 3 months is with the matched group comparison.
The result shows: large, medium and small dosage treated animal generally in order, hematological examination, serum GPT, plasma urea nitrogen etc. experiments is all normal, each dirty body than and matched group no significant difference relatively, each organ-tissue pathologic finding no abnormality seen.
Three, pharmaceutical research:
1, lax esophagus smooth muscle: the mice dislocation causes death, and the taking-up esophagus places and fills the Ke Shi solution bath pipes of constant temperature at 30 degree, by balance recorder, traces contractive amplitude, frequency and tensity.Experiment shows: " containing of dispersing tumor ball " has the effect that continues significant lax esophagus smooth muscle, rapidly lax esophagus smooth muscle in 10.49+3.98 minute after the medication.
2, inhibition and spasmolysis: duplicate esophagus smooth muscle excitement (spasm) model with physostigmine salicylate, add " containing of dispersing tumor ball " immersion then, experiment shows that containing of dispersing tumor ball has obvious suppression and spasmolysis to the esophagus smooth muscle of excited spasm.
3, resist inflammation on repercussive function: adopt Oleum Tiglii Mus ear swelling method.Experiment shows that " containing of dispersing tumor ball " has tangible resist inflammation on repercussive function.
4, analgesic activity: adopt hot plate method, with the positive contrast of morphine.Experiment shows that " containing of dispersing tumor ball " has the powerful pain-stopping effect.
5, change the circulation of general emblem. improve immunity: stumble with taking out intestinal behind the rat anesthesia, be tiled in the glass drying oven that fills with 37 ℃ of normal saline, examine under a microscope the variation of mesentery blood capillary inner blood flow velocity, fluidised form and caliber, the result shows: " containing of dispersing tumor ball " can significantly expand rat mesentery blood capillary caliber, increasing blood flow speed illustrates the microcirculatory effect that has clear improvement of this medical instrument.
6, suppress and kill and wound cancerous cell (Hela): the Hela cell inoculation in the eagle of 15x% calf serum culture medium, after 37 ℃ of cultivations, is calculated the suppression ratio and the kill rate of medicine cell growth.The result shows: " containing of dispersing tumor ball " and positive drug colchicine can obviously suppress and kill and wound the effect of Hela cell, and dose dependent is arranged.
7, hemopoietic function protecting, lower the infringement of chemotherapy to hemopoietic system:
| Leukocyte (10/L) | Hemoglobin (g/L) | Platelet (10/L) | |
| Numerical value＜4.0〉4.0 | <30>80 | <30>30 | |
| Treatment group (%) 40 examples | 9.9 90.1 | 4.45 95.45 | 2.97 97.03 |
| Matched group (%) 40 examples | 20.53 76.47 | 12.75 87.25 | 16.66 86.33 |
In 80 routine digestive system carcinoma patients' comparative study; the treatment group is " containing of a dispersing tumor ball " combined chemotherapy (40 example); matched group is simple chemotherapy (40 example); the result shows: the treatment group can obviously improve hemogram; illustrate that " containing of dispersing tumor ball " has the excellent protection hemopoietic system, strengthen the curative effect of chemotherapy.
Embodiment 1
Take by weighing crude drug of the present invention according to following weight in grams:
Gekko Swinhonis 50g, Rhizoma Paridis 50g, Radix Notoginseng 40g, Bulbus Fritillariae Cirrhosae 40g, Fructus Amomi 40g, Fructus Amomi Rotundus 40g, Radix Glycyrrhizae 30g, Rhizoma Pinelliae Preparata 26g, Radix Rehmanniae Preparata 24g, artificial Calculus Bovis 20g, Rhizoma Coptidis 20g, Fructus Mume 20g, Scorpio 15g, Fructus Gardeniae 15g, Radix Ophiopogonis 15g, Radix Platycodonis 15g, Radix Angelicae Sinensis 15g, Radix Paeoniae Alba 15g, Pericarpium Citri Reticulatae 15g, Scolopendra 10g, Radix Sophorae Tonkinensis 10g and Moschus 1g, roguing, to be ground into fine powder, the mixing of 80 mesh sieves jointly standby; With brown sugar 250g and white sugar 250g, little fire heating boils and adds above-mentioned raw materials medicine fine powder after 0.5 hour, makes the honeyed pill of every ball 9 grams in the 500g Mel, and press mold dress box gets final product.
Embodiment 2
Take by weighing crude drug of the present invention according to following weight in grams:
Gekko Swinhonis 40g, Rhizoma Paridis 60g, Radix Notoginseng 50g, Bulbus Fritillariae Cirrhosae 50g, Fructus Amomi 50g, Fructus Amomi Rotundus 50g, Rhizoma Pinelliae Preparata 30g, Radix Glycyrrhizae 40g, Radix Rehmanniae Preparata 28g, Rhizoma Coptidis 30g, artificial Calculus Bovis 30g, Fructus Mume 30g, Radix Sophorae Tonkinensis 15g, Scolopendra 15g, Scorpio 25g, Fructus Gardeniae 25g, Radix Ophiopogonis 25g, Radix Platycodonis 25g, Radix Angelicae Sinensis 25g, Radix Paeoniae Alba 25g, Pericarpium Citri Reticulatae 25g and Moschus 2g, roguing, to be ground into fine powder, the mixing of 80 mesh sieves jointly standby; With brown sugar 250g and white sugar 250g, little fire heating boils and adds above-mentioned raw materials medicine fine powder after 0.5 hour, makes the honeyed pill of every ball 9 grams in the 500g Mel, and press mold dress box gets final product.
Embodiment 3
Take by weighing crude drug of the present invention according to following weight in grams:
Gekko Swinhonis 60g, Rhizoma Paridis 40g, Radix Notoginseng 30g, Bulbus Fritillariae Cirrhosae 30g, Fructus Amomi 30g, Fructus Amomi Rotundus 30g, Rhizoma Pinelliae Preparata 22g, Radix Glycyrrhizae 20g, Radix Rehmanniae Preparata 20g, Rhizoma Coptidis 10g, artificial Calculus Bovis 10g, Fructus Mume 10g, Radix Sophorae Tonkinensis 5g, Scolopendra 5g, Scorpio 5g, Fructus Gardeniae 5g, Radix Ophiopogonis 5g, Radix Platycodonis 5g, Radix Angelicae Sinensis 5g, Radix Paeoniae Alba 5g, Pericarpium Citri Reticulatae 5g and Moschus 1g, roguing, to be ground into fine powder, the mixing of 80 mesh sieves jointly standby; With brown sugar 250g and white sugar 250g, little fire heating boils and adds above-mentioned raw materials medicine fine powder after 0.5 hour, makes the honeyed pill of every ball 9 grams in the 500g Mel, and press mold dress box gets final product.
Embodiment 4
Take by weighing crude drug of the present invention according to following weight in grams:
Gekko Swinhonis 45g, Rhizoma Paridis 55g, Radix Notoginseng 45g, Bulbus Fritillariae Cirrhosae 45g, Fructus Amomi 45g, Fructus Amomi Rotundus 45g, Radix Glycyrrhizae 35g, Rhizoma Pinelliae Preparata 28g, Radix Rehmanniae Preparata 26g, Fructus Mume 25g, Rhizoma Coptidis 25g, artificial Calculus Bovis 25g, Fructus Gardeniae 20g, Radix Ophiopogonis 20g, Radix Platycodonis 20g, Radix Angelicae Sinensis 20g, Radix Paeoniae Alba 20g, Scorpio 20g, Scorpio 20g, Pericarpium Citri Reticulatae 20g, Scolopendra 15g, Radix Sophorae Tonkinensis 12g, Moschus 0.05g, roguing, to be ground into fine powder, the mixing of 80 mesh sieves jointly standby; With brown sugar 250g and white sugar 250g, little fire heating boils and adds above-mentioned raw materials medicine fine powder after 0.5 hour, makes the honeyed pill of every ball 9 grams in the 500g Mel, and press mold dress box gets final product.
Claims (5)
1. pharmaceutical composition for the treatment of digestive system carcinoma is formed by the following bulk drugs processed with honey:
Gekko Swinhonis 40～60 weight portions; Rhizoma Paridis 40～60 weight portions; Radix Notoginseng 30～50 weight portions; Bulbus Fritillariae Cirrhosae 30～50 weight portions; Fructus Amomi 30～50 weight portions; Fructus Amomi Rotundus 30～50 weight portions; Rhizoma Pinelliae Preparata 22～30 weight portions; Radix Glycyrrhizae 20～40 weight portions; Radix Rehmanniae Preparata 20～28 weight portions; Rhizoma Coptidis 10～30 weight portions; artificial Calculus Bovis's 10～30 weight portions; Fructus Mume 10～30 weight portions; Radix Sophorae Tonkinensis 5～15 weight portions; Scolopendra 5～15 weight portions; Scorpio 5～25 weight portions; Fructus Gardeniae 5～25 weight portions; Radix Ophiopogonis 5～25 weight portion; Radix Platycodonis 5～25 weight portions; Radix Angelicae Sinensis 5～25 weight portions; the Radix Paeoniae Alba 5～25 weight portions; Pericarpium Citri Reticulatae 5～25 weight portions; Moschus 0～2 weight portion.
2. a kind of pharmaceutical composition for the treatment of digestive system carcinoma according to claim 1 is formed by the following bulk drugs processed with honey:
Gekko Swinhonis 45～55 weight portions; Rhizoma Paridis 45～55 weight portions; Radix Notoginseng 35～45 weight portions; Bulbus Fritillariae Cirrhosae 35～45 weight portions; Fructus Amomi 35～45 weight portions; Fructus Amomi Rotundus 35～45 weight portions; Radix Glycyrrhizae 25～35 weight portions; Rhizoma Pinelliae Preparata 24～28 weight portions; Radix Rehmanniae Preparata 22～26 weight portions; Fructus Mume 15～25 weight portions; Rhizoma Coptidis 15～25 weight portions; artificial Calculus Bovis's 15～25 weight portions; Fructus Gardeniae 10～20 weight portions; Radix Ophiopogonis 10～20 weight portion; Radix Platycodonis 10～20 weight portions; Radix Angelicae Sinensis 10～20 weight portions; the Radix Paeoniae Alba 10～20 weight portions; Scorpio 10～20 weight portions; Scorpio 10～20 weight portions; Pericarpium Citri Reticulatae 10～20 weight portions; Scolopendra 5～15 weight portions; Radix Sophorae Tonkinensis 8～12 weight portions; Moschus 0～2 weight portion.
3. a kind of pharmaceutical composition for the treatment of digestive system carcinoma according to claim 2 is formed by the following bulk drugs processed with honey:
Gekko Swinhonis 50 weight portions; Rhizoma Paridis 50 weight portions; Radix Notoginseng 40 weight portions; Bulbus Fritillariae Cirrhosae 40 weight portions; Fructus Amomi 40 weight portions; Fructus Amomi Rotundus 40 weight portions; Radix Glycyrrhizae 30 weight portions; Rhizoma Pinelliae Preparata 26 weight portions; Radix Rehmanniae Preparata 24 weight portions; artificial Calculus Bovis's 20 weight portions; Rhizoma Coptidis 20 weight portions; Fructus Mume 20 weight portions; Scorpio 15 weight portions; Fructus Gardeniae 15 weight portions; Radix Ophiopogonis 15 weight portion; Radix Platycodonis 15 weight portions; Radix Angelicae Sinensis 15 weight portions; the Radix Paeoniae Alba 15 weight portions; Pericarpium Citri Reticulatae 15 weight portions; Scolopendra 10 weight portions; Radix Sophorae Tonkinensis 10 weight portions; Moschus 1 weight portion.
4. method for preparing the described pharmaceutical composition of claim 1～3 is characterized in that:
Above-mentioned each crude drug is weighed respectively, roguing, is ground into fine powder and crosses 80 mesh sieves according to weight portion, and mixing is standby; Add brown sugar, the little fire heating of each 250 gram of white sugar with 500 gram weight part refined honeys and boil the fusing back half an hour and add above-mentioned raw material medicated powder, compacting forms.
5. preparation method according to claim 4 is characterized in that: the Rhizoma Pinelliae in the crude drug is a Rhizoma Pinelliae with behind the Rhizoma Zingiberis Recens decocting in water, cuts into slices, dries and form.
Priority Applications (1)
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| CN1287003A (en) * | 1999-09-06 | 2001-03-14 | 霍天增 | Medicine for treating carcer of esophagus and its preparation |
| CN1101209C (en) * | 2000-09-18 | 2003-02-12 | 武超 | Medicine for treating digestive tract diseases |
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| CN1287003A (en) * | 1999-09-06 | 2001-03-14 | 霍天增 | Medicine for treating carcer of esophagus and its preparation |
| CN1101209C (en) * | 2000-09-18 | 2003-02-12 | 武超 | Medicine for treating digestive tract diseases |
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| Title |
|---|
| 叶加等.食管癌中医及中西医结合临床治疗进展.《中医杂志》.2000,第41卷(第11期),第693-695页. * |
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