CN104095930B - A kind of Chinese medicine for the treatment of gastrorrhagia - Google Patents
A kind of Chinese medicine for the treatment of gastrorrhagia Download PDFInfo
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Abstract
The invention discloses a kind of Chinese medicine for the treatment of gastrorrhagia, be made up of the raw material of following weight portion: Herba Ecliptae 25 ~ 45 parts, Herba Cirsii 20 ~ 30 parts, 15 ~ 30 parts, Auricularia, Nodus Nelumbinis Rhizomatis 5 ~ 15 parts, 2 ~ 9 parts, Radix Glycyrrhizae, also comprise Radix Angelicae Sinensis 5 ~ 10 parts.By Chinese medicine treatment gastrorrhagia of the present invention, short treating period, evident in efficacy, taking convenience, saves time.
Description
Technical field
The present invention relates to technical field of Chinese medicines, particularly a kind of Chinese medicine for the treatment of gastrorrhagia.
Background technology
Gastrorrhagia is commonly called as upper gastrointestinal hemorrhage, and more than 40% is caused by taste-blindness rate, and overwork fatigue, diet is irregular, mood disorders is nervous etc. has the crowd of digestive tract medical history easily to fall ill; Next is the gastrorrhagia that acute haemorrhagic gastritis causes, and the gastrorrhagia major part that these two kinds of reasons cause can obtain effective treatment after regular treatment.Be the gastrorrhagia that liver cirrhosis causes in addition, patient with liver cirrhosis generally all can develop into esophagus fundus ventricularis varication, if eat roughage, emotion overstimulation again, the vein blood vessel explosion of Gastroesophageal massive hemorrhage will occur.The mortality rate of gastrorrhagia is up to 8 ~ 13.7%.
The clinical manifestation of gastrorrhagia is: hematemesis and (or) melena, blood loss peripheral circulatory failure, azotemia, anemia and blood change and heating.Wherein, hematemesis and (or) melena are the characteristic performances of upper gastrointestinal hemorrhage.Often there are hematemesis and melena in bleeding part the above person of pylorus, and below pylorus, person only can show as melena.But the above pathological changes of the few and slow-footed pylorus of amount of bleeding can rarely seen melena, and the pathological changes below large, the fireballing pylorus of amount of bleeding can flow into stomach because of blood reflux, causes hematemesis.
At present, the medicine for the treatment of gastrorrhagia has a lot, the Therapeutic Principle of doctor trained in Western medicine to gastrorrhagia takes Western medicine, by reducing Acidity in the stomach in case hydrion back diffusion and increase the weight of gastric mucosa damage, actively stopping blooding, and being aided with blood transfusion infusion, treatment time is short, but treatment curative effect is not very desirable, and easily recurs, and side effect is large; Chinese patent medicine side effect is little, but treatment time is long, and the composition of medicine is comparatively complicated, and therapeutic effect is not obvious.In recent years, Chinese medicine is little, evident in efficacy because of its toxic and side effects, enjoys the favor of gastrorrhagia patient, and find a kind of curative effect fast, Be very effective, the Chinese medicine that toxic and side effects is little is treated gastrorrhagia and become most important.
Summary of the invention
Technical problem to be solved by this invention is to provide the Chinese medicine of the treatment gastrorrhagia that a kind of curative effect is fast, toxic and side effects is little.
For achieving the above object, the present invention takes following technical scheme:
Treat a Chinese medicine for gastrorrhagia, be made up of the raw material of following weight portion: Herba Ecliptae 25 ~ 45 parts, Herba Cirsii 20 ~ 30 parts, 15 ~ 30 parts, Auricularia, Nodus Nelumbinis Rhizomatis 5 ~ 15 parts, 2 ~ 9 parts, Radix Glycyrrhizae, Radix Angelicae Sinensis 5 ~ 10 parts.
The Chinese medicine for the treatment of gastrorrhagia of the present invention, its preparation method is as follows:
(1) Herba Ecliptae, Herba Cirsii, Auricularia, Nodus Nelumbinis Rhizomatis, Radix Glycyrrhizae, Radix Angelicae Sinensis powder are broken into 150 ~ 300 order powder, add raw material gross weight 3 ~ 4 times of water, add 1% ~ 2% cellulase and 1% ~ 2% pectase of raw material gross weight again, 40 DEG C ~ 45 DEG C lixiviates 2 ~ 3 hours, filter, collect lixiviating solution, by filtering residue dry for standby;
(2) in filtering residue for subsequent use, add filtering residue gross weight 8 ~ 12 times of ethanol, reflux, extract, 25 ~ 35min, collect first time extracting solution; Add filtering residue gross weight 5 ~ 8 times of ethanol again, reflux, extract, 30 ~ 40min, collect second time extracting solution; Add filtering residue gross weight 3 ~ 5 times of ethanol again, reflux, extract, 35 ~ 45min, collect third time extracting solution, merge three extracting solution, obtain extracting solution, described ethanol contend concentration is 65% ~ 95%, and described three reflux, extract, are all extracted at 40 DEG C ~ 50 DEG C temperature.
(3) lixiviating solution and extracting solution are merged, compression, spraying dry, the Chinese medicine powder of obtained treatment gastrorrhagia.
The Chinese medicine for the treatment of gastrorrhagia of the present invention, preferably, is made up of the raw material of following weight portion: Herba Ecliptae 30 ~ 40 parts, Herba Cirsii 23 ~ 27 parts, 20 ~ 25 parts, Auricularia, Nodus Nelumbinis Rhizomatis 10 ~ 13 parts, 5 ~ 8 parts, Radix Glycyrrhizae.
The Chinese medicine for the treatment of gastrorrhagia of the present invention, best, is made up of the raw material of following weight portion: Herba Ecliptae 35 parts, Herba Cirsii 25 parts, 23 parts, Auricularia, Nodus Nelumbinis Rhizomatis 12 parts, 6 parts, Radix Glycyrrhizae, Radix Angelicae Sinensis 8 parts.
Take for convenience, the Chinese medicine powder for the treatment of gastrorrhagia of the present invention can be made into tablet or pill.
In the Traditional Chinese medicine raw material for the treatment of gastrorrhagia of the present invention:
Herba Ecliptae is the aerial parts of feverfew Eclipta prostrata Eclipta prostrata L..Nature and flavor: sweet in the mouth acid, cool in nature, enter Liver and kidney two warp, nontoxic.Function cures mainly: nourishing the liver and kidney, cooling blood for hemostasis, can control various haematemesis, the diseases such as gastrointestinal haemorrhagia.
Herba Cirsii is the aerial parts of feverfew field thistle Cephalanoplos segetum (Bunge) Kitam..Nature and flavor: sweet, bitter, cold.Function cures mainly: cooling blood for hemostasis, removing blood stasis to reduce swelling; For epistaxis, spit blood, hematuria, has blood in stool, metrostaxis, traumatic hemorrhage, carbuncle sore tumefacting virus.
Auricularia, being the edible fungi of Auricularia (formal name used at school: Auricularia or Wood ear), is sporophore colloid, becomes disc, the irregular shape of ear shape, diameter 3-12 centimetre.Nature and flavor: mouthfeel is delicate, and local flavor is special.Function cures mainly: fill blood, lung moistening, hemostasis; For Qi and blood deficiency, extremity are twitched, cough due to deficiency of the lung, spitting of blood, spit blood, epistaxis, metrorrhagia, hypertension, constipation.
Nodus Nelumbinis Rhizomatis: be Rhizoma Nelumbinis coupling part.Nature and flavor: property is flat, sweet-puckery flavor.Function cures mainly: the effect having hemostasis scattered silt, controls hemoptysis, haematemesis, hematuria, has blood in stool, metrorrhagia etc.
Radix Angelicae Sinensis is herbaceos perennial root.Nature and flavor: sweet, pungent, temperature.Function cures mainly: enrich blood, and invigorates blood circulation, and menstruction regulating and pain relieving moisturizes laxation.
Radix Glycyrrhizae is pulse family, Glycyrrhiza perennial herb root and rhizome.Nature and flavor: sweet are flat.Function cures mainly: heat-clearing and toxic substances removing, expelling phlegm for arresting cough, gastral cavity abdomen etc.
Compared with prior art, beneficial effect of the present invention is:
(1) reasonable recipe, do not stop blooding merely, also there is removing heat from blood, blood tonification effect, treating both the principal and the secondary aspects of a disease at the same time, as the Auricularia contained in Chinese medicine, not only can stop blooding but can removing heat from blood, enrich blood, the Radix Angelicae Sinensis added has the effect of enriching blood, and is beneficial to patient and recovers, and Radix Glycyrrhizae has mediation property of medicine effect, strengthen drug effect, other component is hemostasia effect.
(2) Time of Administration is short, instant effect, and Chinese medicine makes tablet or pill, conveniently takes, and saves time.
(3) in the present invention without any additive, toxic and side effects is little.
Detailed description of the invention
Below in conjunction with embodiment, the invention will be further described, but the present invention is not limited to these embodiments.
Embodiment 1
Treat a Chinese medicine for gastrorrhagia, be made up of the raw material of following weight portion: Herba Ecliptae 25 parts, Herba Cirsii 20 parts, 15 parts, Auricularia, Nodus Nelumbinis Rhizomatis 5 parts, 2 parts, Radix Glycyrrhizae, Radix Angelicae Sinensis 5 parts.
(1) Herba Ecliptae, Herba Cirsii, Auricularia, Nodus Nelumbinis Rhizomatis, Radix Glycyrrhizae, Radix Angelicae Sinensis powder are broken into 150 order powder, add raw material gross weight 3 times of water, then add 1% cellulase and 1% pectase of raw material gross weight, 40 DEG C of lixiviates 2 hours, filter, collect lixiviating solution, by filtering residue dry for standby;
(2) in filtering residue for subsequent use, add filtering residue gross weight 8 times of ethanol, reflux, extract, 25min, collect first time extracting solution; Add filtering residue gross weight 5 times of ethanol again, reflux, extract, 30min, collect second time extracting solution; Add filtering residue gross weight 3 times of ethanol again, reflux, extract, 35min, collect third time extracting solution, merge three extracting solution, obtain extracting solution, described ethanol contend concentration is 65%, and described three reflux, extract, are all carried out at 40 DEG C of temperature;
(3) lixiviating solution and extracting solution are merged, compression, spraying dry, the Chinese medicine powder of obtained treatment gastrorrhagia, makes tablet by Chinese medicine powder.
Embodiment 2
Treat a Chinese medicine for gastrorrhagia, be made up of the raw material of following weight portion: Herba Ecliptae 30 parts, Herba Cirsii 23 parts, 20 parts, Auricularia, Nodus Nelumbinis Rhizomatis 10 parts, 5 parts, Radix Glycyrrhizae, Radix Angelicae Sinensis 6 parts.
(1) Herba Ecliptae, Herba Cirsii, Auricularia, Nodus Nelumbinis Rhizomatis, Radix Glycyrrhizae, Radix Angelicae Sinensis powder are broken into 180 order powder, add raw material gross weight 4 times of water, then add 2% cellulase and 2% pectase of raw material gross weight, 42 DEG C of lixiviates 2.5 hours, filter, collect lixiviating solution, by filtering residue dry for standby;
(2) in filtering residue for subsequent use, add filtering residue gross weight 9 times of ethanol, reflux, extract, 30min, collect first time extracting solution; Add filtering residue gross weight 7 times of ethanol again, reflux, extract, 35min, collect second time extracting solution; Add filtering residue gross weight 4 times of ethanol again, reflux, extract, 40min, collect third time extracting solution, merge three extracting solution, obtain extracting solution, described ethanol contend concentration is 70%, and described three reflux, extract, are all carried out at 45 DEG C of temperature;
(3) lixiviating solution and extracting solution are merged, compression, spraying dry, the Chinese medicine powder of obtained treatment gastrorrhagia, makes tablet by Chinese medicine powder.
Embodiment 3
Treat a Chinese medicine for gastrorrhagia, be made up of the raw material of following weight portion: Herba Ecliptae 35 parts, Herba Cirsii 25 parts, 23 parts, Auricularia, Nodus Nelumbinis Rhizomatis 12 parts, 6 parts, Radix Glycyrrhizae, Radix Angelicae Sinensis 8 parts.
(1) Herba Ecliptae, Herba Cirsii, Auricularia, Nodus Nelumbinis Rhizomatis, Radix Glycyrrhizae, Radix Angelicae Sinensis powder are broken into 200 order powder, add raw material gross weight 3.5 times of water, then add 2% cellulase and 1% pectase of raw material gross weight, 43 DEG C of lixiviates 3 hours, filter, collect lixiviating solution, by filtering residue dry for standby;
(2) in filtering residue for subsequent use, add filtering residue gross weight 10 times of ethanol, reflux, extract, 30min, collect first time extracting solution; Add filtering residue gross weight 7 times of ethanol again, reflux, extract, 35min, collect second time extracting solution; Add filtering residue gross weight 4 times of ethanol again, reflux, extract, 40min, collect third time extracting solution, merge three extracting solution, obtain extracting solution, described ethanol contend concentration is 80%, and described three reflux, extract, are all carried out at 45 DEG C of temperature;
(3) lixiviating solution and extracting solution are merged, compression, spraying dry, the Chinese medicine powder of obtained treatment gastrorrhagia, makes pill by Chinese medicine powder.
Embodiment 4
Treat a Chinese medicine for gastrorrhagia, be made up of the raw material of following weight portion: Herba Ecliptae 35 parts, Herba Cirsii 25 parts, 23 parts, Auricularia, Nodus Nelumbinis Rhizomatis 12 parts, 6 parts, Radix Glycyrrhizae, Radix Angelicae Sinensis 9 parts.
(1) Herba Ecliptae, Herba Cirsii, Auricularia, Nodus Nelumbinis Rhizomatis, Radix Glycyrrhizae, Radix Angelicae Sinensis powder are broken into 250 order powder, add raw material gross weight 3 times of water, then add 2% cellulase and 2% pectase of raw material gross weight, 44 DEG C of lixiviates 3 hours, filter, collect lixiviating solution, by filtering residue dry for standby;
(2) in filtering residue for subsequent use, add filtering residue gross weight 11 times of ethanol, reflux, extract, 35min, collect first time extracting solution; Add filtering residue gross weight 8 times of ethanol again, reflux, extract, 30min, collect second time extracting solution; Add filtering residue gross weight 4 times of ethanol again, reflux, extract, 45min, collect third time extracting solution, merge three extracting solution, obtain extracting solution, described ethanol contend concentration is 85%, and described three reflux, extract, are all carried out at 45 DEG C of temperature;
(3) lixiviating solution and extracting solution are merged, compression, spraying dry, the Chinese medicine powder of obtained treatment gastrorrhagia, makes pill by Chinese medicine powder.
Embodiment 5
Treat a Chinese medicine for gastrorrhagia, be made up of the raw material of following weight portion: Herba Ecliptae 45 parts, Herba Cirsii 30 parts, 30 parts, Auricularia, Nodus Nelumbinis Rhizomatis 15 parts, 9 parts, Radix Glycyrrhizae, Radix Angelicae Sinensis 10 parts.
(1) Herba Ecliptae, Herba Cirsii, Auricularia, Nodus Nelumbinis Rhizomatis, Radix Glycyrrhizae, Radix Angelicae Sinensis powder are broken into 300 order powder, add raw material gross weight 4 times of water, then add 2% cellulase and 1% pectase of raw material gross weight, 45 DEG C of lixiviates 3 hours, filter, collect lixiviating solution, by filtering residue dry for standby;
(2) in filtering residue for subsequent use, add filtering residue gross weight 12 times of ethanol, reflux, extract, 35min, collect first time extracting solution; Add filtering residue gross weight 8 times of ethanol again, reflux, extract, 40min, collect second time extracting solution; Add filtering residue gross weight 5 times of ethanol again, reflux, extract, 45min, collect third time extracting solution, merge three extracting solution, obtain extracting solution, described ethanol contend concentration is 95%, and described three reflux, extract, are all carried out at 50 DEG C of temperature;
(3) lixiviating solution and extracting solution are merged, compression, spraying dry, the Chinese medicine powder of obtained treatment gastrorrhagia, makes tablet by Chinese medicine powder.
Test example
1, diagnostic criteria:
Originally often have nauseating, stomach discomfort or pain, vomitus is in coffee-like or kermesinus, it is cerise that many persons are measured in haematemesis, accompanies error residue more, is mixed with gastric juice, or black stool is pitch shape, can there is Zhi Leng, sweating, increased heart rate and color is pale or faint in the many persons of amount of bleeding.
2, physical data:
In January, 2012 ~ 2013 year December is diagnosed as patient 120 example of gastrorrhagia, tests in institute of traditional Chinese medicine of Guilin City.
3, extent of hemorrhage is estimated:
Hyporrhea: ﹤ 500ml/24h, has dizziness, nervous.
Moderate is hemorrhage: 24h ﹥ 500ml ~ 1000ml, pale complexion, palpitation and short breath.
Severe bleeding: 24h more than ﹥ 1500ml, shock.
4, Therapeutic Method:
120 routine gastrorrhagia patients are divided into 3 groups at random, often organize 40 people, be respectively embodiment 1 group, embodiment 3 groups, contrast groups, wherein in embodiment 1 group, severe bleeding 7 example, hemorrhage 24 examples of moderate, hyporrhea 9 example; In embodiment 3 groups, severe bleeding 8 example, hemorrhage 25 examples of moderate, hyporrhea 7 example; In contrast groups, severe bleeding 8 example, hemorrhage 24 examples of moderate, hyporrhea 8 example.Three groups of cases are in sex, age, the course of disease, and protopathy and state of an illness aspect compare, without significant difference.
Embodiment 1 group, Example 1 tablet 8g, joins 50ml normal saline, oral, every day 3 times; Embodiment 3 groups, Example 3 pill 8g, joins 50ml normal saline, oral, every day 3 times; Contrast groups, give positive kidney brine ice, norepinephrine 8mg adds in 100ml normal saline, puts into refrigerator cold-storage, makes fluid temperature be chilled to 3 DEG C ~ 4 DEG C, and points 3 ~ 4 times/day oral or through Injection by stomach duct.
First 3 days every 2h record mind, blood pressure, heart rate, breathing, borborygmus and vomiting, defecation, urine volume situation, look into 1 routine blood test, each stool every day all to look into and occult blood, simultaneously itemized record stomachache, dizzy, nervous, feed and the situation such as complication, adverse effect, every day entry 3 times after stable disease.
Adopt the process of SPSS11.0 analysis software, the efficacy analysis between group adopts Ridit to analyze, enumeration data χ
2inspection, measurement data t checks, and is all significant difference with P<0.05.
5, therapeutic evaluation:
Effective: spit blood in 1 week or melena stopping, stool color turns yellow, and fecal occult blood is little, and hemorrhage simultaneous phenomenon makes moderate progress, without recurring in 1 year.
Effective: within 1 week, internal hemorrhage is less, stool color turns yellow, and fecal occult blood is less, and hemorrhage simultaneous phenomenon slightly improves.
Invalid: hemorrhagely not subtract through controlling 1 week, fecal occult blood is without improvement; Severe bleeding, without taking a turn for the better after controlling 24h, hemorrhage simultaneous phenomenon is without improvement.
6, result of the test:
Table 1 embodiment of the present invention 1, embodiment 3 are to the result of the test for the treatment of gastrorrhagia
| Group | Number of cases | Effective | Effectively | Invalid | Effective percentage (%) |
| Embodiment 1 group | 40 | 37 | 3 | 0 | 100 |
| Embodiment 3 groups | 40 | 38 | 2 | 0 | 100 |
| Contrast groups | 40 | 22 | 11 | 7 | 82.5 |
Bleeding stopping period and the fecal occult blood clearance time of two groups of cases compare: the bleeding stopping period of result display embodiment 1 group and fecal occult blood clearance time (2.21 ± 0.64d, 3.11 ± 1.12d); The bleeding stopping period that embodiment is 3 groups and fecal occult blood clearance time (2.11 ± 0.45d, 3.01 ± 1.09d); Contrast groups (3.78 ± 1.11d, 5.21 ± 1.37d).
As can be seen from Table 1, embodiment 1 group, embodiment 3 groups treatment gastrorrhagia effective percentage is apparently higher than contrast groups, evident in efficacy.Compare from bleeding stopping period and fecal occult blood time, embodiment 1 group, embodiment 3 groups are obviously less than contrast groups, illustrate that the Chinese medicine for the treatment of gastrorrhagia of the present invention obviously can shorten bleeding stopping period and fecal occult blood time, determined curative effect.
Claims (3)
1. treat a Chinese medicine for gastrorrhagia, it is characterized in that, be made up of the raw material of following weight portion: Herba Ecliptae 25 ~ 45 parts, Herba Cirsii 20 ~ 30 parts, 15 ~ 30 parts, Auricularia, Nodus Nelumbinis Rhizomatis 5 ~ 15 parts, 2 ~ 9 parts, Radix Glycyrrhizae, Radix Angelicae Sinensis 5 ~ 10 parts;
The Chinese medicine of described treatment gastrorrhagia, its preparation method comprises the steps:
(1) Herba Ecliptae, Herba Cirsii, Auricularia, Nodus Nelumbinis Rhizomatis, Radix Glycyrrhizae, Radix Angelicae Sinensis powder are broken into 150 ~ 300 order powder, add raw material gross weight 3 ~ 4 times of water, add 1% ~ 2% cellulase and 1% ~ 2% pectase of raw material gross weight again, 40 DEG C ~ 45 DEG C lixiviates 2 ~ 3 hours, filter, collect lixiviating solution, by filtering residue dry for standby;
(2) in filtering residue for subsequent use, add filtering residue gross weight 8 ~ 12 times of ethanol, reflux, extract, 25 ~ 35min, collect first time extracting solution; Add filtering residue gross weight 5 ~ 8 times of ethanol again, reflux, extract, 30 ~ 40min, collect second time extracting solution; Add filtering residue gross weight 3 ~ 5 times of ethanol again, reflux, extract, 35 ~ 45min, collect third time extracting solution, merge three extracting solution, obtain extracting solution, described ethanol contend concentration is 65% ~ 95%, and described three reflux, extract, are all carried out at 40 DEG C ~ 50 DEG C temperature;
(3) lixiviating solution and extracting solution are merged, compression, spraying dry, the Chinese medicine powder of obtained treatment gastrorrhagia.
2. the Chinese medicine for the treatment of gastrorrhagia according to claim 1, is characterized in that, is made up of the raw material of following weight portion: Herba Ecliptae 35 parts, Herba Cirsii 25 parts, 23 parts, Auricularia, Nodus Nelumbinis Rhizomatis 12 parts, 6 parts, Radix Glycyrrhizae, Radix Angelicae Sinensis 8 parts.
3. the Chinese medicine for the treatment of gastrorrhagia according to claim 2, is characterized in that: described Chinese medicine powder can be made into tablet or pill.
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